Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3-mercaptopyruvate sulfurtransferase activity	MPST TST	1.96e-05	2	89	2	GO:0016784
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1B LRP8 SORL1	4.60e-05	16	89	3	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1B LRP8 SORL1	1.07e-04	21	89	3	GO:0030228
GeneOntologyMolecularFunction	structural constituent of eye lens	CRYBA1 CRYBA4 LIM2	1.62e-04	24	89	3	GO:0005212
GeneOntologyMolecularFunction	thiosulfate sulfurtransferase activity	MPST TST	1.95e-04	5	89	2	GO:0004792
GeneOntologyMolecularFunction	glutathione transmembrane transporter activity	ABCC1 SLC13A3	4.07e-04	7	89	2	GO:0034634
GeneOntologyMolecularFunction	ABC-type glutathione S-conjugate transporter activity	ABCC1 ABCC6	5.41e-04	8	89	2	GO:0015431
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	GABRP ABCC1 SLC39A11 PKD1 KCNQ1 SLC37A2 SLC13A3 GRIN2D ATP2A2 KCNAB3 ABCC6	5.41e-04	758	89	11	GO:0015318
GeneOntologyMolecularFunction	tripeptide transmembrane transporter activity	ABCC1 SLC13A3	6.93e-04	9	89	2	GO:0042937
GeneOntologyMolecularFunction	transmembrane transporter activity	GABRP ABCC1 SLC39A11 PKD1 KCNQ1 LRP5 SLC37A2 SLC13A3 GRIN2D ATP2A2 SLC29A2 KCNAB3 SLC7A14 ABCC6	6.98e-04	1180	89	14	GO:0022857
GeneOntologyMolecularFunction	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	ASNSD1 NADSYN1	8.64e-04	10	89	2	GO:0016884
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC1 ABCC6	8.64e-04	10	89	2	GO:0043225
GeneOntologyMolecularFunction	sulfurtransferase activity	MPST TST	1.26e-03	12	89	2	GO:0016783
GeneOntologyBiologicalProcess	cyanate catabolic process	MPST TST	1.84e-05	2	89	2	GO:0009440
GeneOntologyBiologicalProcess	cyanate metabolic process	MPST TST	1.84e-05	2	89	2	GO:0009439
GeneOntologyCellularComponent	anchoring collagen complex	COL7A1 COL12A1	5.36e-05	3	89	2	GO:0030934
Domain	Ldl_recept_b	LRP4 LRP5 LRP1B LRP8 SORL1	4.01e-09	14	88	5	PF00058
Domain	LDLRB	LRP4 LRP5 LRP1B LRP8 SORL1	4.01e-09	14	88	5	PS51120
Domain	LY	LRP4 LRP5 LRP1B LRP8 SORL1	5.99e-09	15	88	5	SM00135
Domain	LDLR_classB_rpt	LRP4 LRP5 LRP1B LRP8 SORL1	5.99e-09	15	88	5	IPR000033
Domain	LDLRA_1	PKD1 LRP4 LRP5 LRP1B LRP8 SORL1	9.64e-08	48	88	6	PS01209
Domain	LDLRA_2	PKD1 LRP4 LRP5 LRP1B LRP8 SORL1	1.09e-07	49	88	6	PS50068
Domain	-	LRP4 LRP5 LRP1B LRP8 SORL1	1.05e-06	39	88	5	2.120.10.30
Domain	LDLR_class-A_CS	LRP4 LRP5 LRP1B LRP8 SORL1	1.20e-06	40	88	5	IPR023415
Domain	Ldl_recept_a	LRP4 LRP5 LRP1B LRP8 SORL1	2.18e-06	45	88	5	PF00057
Domain	-	LRP4 LRP5 LRP1B LRP8 SORL1	2.44e-06	46	88	5	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP4 LRP5 LRP1B LRP8 SORL1	2.44e-06	46	88	5	IPR011042
Domain	LDrepeatLR_classA_rpt	LRP4 LRP5 LRP1B LRP8 SORL1	3.35e-06	49	88	5	IPR002172
Domain	LDLa	LRP4 LRP5 LRP1B LRP8 SORL1	3.35e-06	49	88	5	SM00192
Domain	RHODANESE_2	MPST TST	2.19e-05	2	88	2	PS00683
Domain	RHODANESE_1	MPST TST	2.19e-05	2	88	2	PS00380
Domain	Thiosulphate_STrfase_CS	MPST TST	6.56e-05	3	88	2	IPR001307
Domain	EGF_3	RELN LRP4 LRP5 LRP1B IMPG2 LRP8 SORL1	1.22e-04	235	88	7	PS50026
Domain	Multidrug-R_assoc	ABCC1 ABCC6	1.31e-04	4	88	2	IPR005292
Domain	EGF-like_dom	RELN LRP4 LRP5 LRP1B IMPG2 LRP8 SORL1	1.74e-04	249	88	7	IPR000742
Domain	WSC	KREMEN2 PKD1	2.17e-04	5	88	2	SM00321
Domain	WSC_carb-bd	KREMEN2 PKD1	2.17e-04	5	88	2	IPR002889
Domain	WSC	KREMEN2 PKD1	2.17e-04	5	88	2	PF01822
Domain	GLYCOSYL_HYDROL_F31_2	SI MYORG	2.17e-04	5	88	2	PS00707
Domain	WSC	KREMEN2 PKD1	2.17e-04	5	88	2	PS51212
Domain	EGF-like_CS	RELN LRP4 LRP5 LRP1B IMPG2 LRP8 SORL1	2.33e-04	261	88	7	IPR013032
Domain	EGF_2	RELN LRP4 LRP5 LRP1B IMPG2 LRP8 SORL1	2.55e-04	265	88	7	PS01186
Domain	Glyco_hydro_31	SI MYORG	4.54e-04	7	88	2	IPR000322
Domain	Glyco_hydro_31	SI MYORG	4.54e-04	7	88	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	SI MYORG	4.54e-04	7	88	2	PS00129
Domain	Sialidases	RELN SORL1	7.73e-04	9	88	2	IPR011040
Domain	EGF	RELN LRP4 LRP5 LRP1B LRP8 SORL1	8.54e-04	235	88	6	SM00181
Domain	EGF_CA	LRP4 LRP5 LRP1B LRP8	1.23e-03	99	88	4	PS01187
Domain	EGF_1	RELN LRP4 LRP5 LRP1B IMPG2 LRP8	1.30e-03	255	88	6	PS00022
Domain	OxRdtase_FAD/NAD-bd	CYB5RL NOS3	1.40e-03	12	88	2	IPR001433
Domain	NAD_binding_1	CYB5RL NOS3	1.40e-03	12	88	2	PF00175
Domain	CRYSTALLIN_BETA_GAMMA	CRYBA1 CRYBA4	2.21e-03	15	88	2	PS50915
Domain	Crystall	CRYBA1 CRYBA4	2.21e-03	15	88	2	PF00030
Domain	Beta/gamma_crystallin	CRYBA1 CRYBA4	2.21e-03	15	88	2	IPR001064
Domain	XTALbg	CRYBA1 CRYBA4	2.21e-03	15	88	2	SM00247
Domain	EGF-like_Ca-bd_dom	LRP4 LRP5 LRP1B LRP8	2.81e-03	124	88	4	IPR001881
Domain	EGF	LRP4 LRP5 LRP1B LRP8	2.98e-03	126	88	4	PF00008
Domain	G_crystallin-rel	CRYBA1 CRYBA4	3.20e-03	18	88	2	IPR011024
Domain	Fd_Rdtase_FAD-bd	CYB5RL NOS3	3.56e-03	19	88	2	IPR017927
Domain	FAD_FR	CYB5RL NOS3	3.56e-03	19	88	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	CYB5RL NOS3	3.56e-03	19	88	2	IPR017938
Domain	FA58C	DDR2 DCBLD2	4.35e-03	21	88	2	SM00231
Domain	FA58C_3	DDR2 DCBLD2	4.35e-03	21	88	2	PS50022
Domain	FA58C_1	DDR2 DCBLD2	4.35e-03	21	88	2	PS01285
Domain	FA58C_2	DDR2 DCBLD2	4.35e-03	21	88	2	PS01286
Domain	RHOD	MPST TST	4.77e-03	22	88	2	SM00450
Domain	-	FBXO6 DDR2 DCBLD2	4.96e-03	73	88	3	2.60.120.260
Domain	RHODANESE_3	MPST TST	5.21e-03	23	88	2	PS50206
Domain	F5_F8_type_C	DDR2 DCBLD2	5.66e-03	24	88	2	PF00754
Domain	FA58C	DDR2 DCBLD2	5.66e-03	24	88	2	IPR000421
Domain	Rhodanese-like_dom	MPST TST	5.66e-03	24	88	2	IPR001763
Domain	Rhodanese	MPST TST	5.66e-03	24	88	2	PF00581
Domain	ABC_membrane	ABCC1 ABCC6	5.66e-03	24	88	2	PF00664
Domain	-	MPST TST	5.66e-03	24	88	2	3.40.250.10
Domain	cEGF	LRP4 LRP1B	6.63e-03	26	88	2	IPR026823
Domain	cEGF	LRP4 LRP1B	6.63e-03	26	88	2	PF12662
Domain	ABC_TM1F	ABCC1 ABCC6	7.66e-03	28	88	2	PS50929
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ABCC1 COL7A1 B4GALT7 COL12A1 FDFT1 SUN2 LRP4 LRP5 ATP2A2 LRP1B POFUT2 DCBLD2 ALG12 RCN3 MYORG STT3A LRP8 SORL1	1.87e-09	1201	91	18	35696571
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	TYR LRP4 LRP5 LRP1B LRP8	2.16e-09	21	91	5	21337463
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP4 LRP5 LRP1B	2.82e-06	11	91	3	24639464
Pubmed	Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease.	ACE NOS3	6.77e-06	2	91	2	11485372
Pubmed	Association between genetic polymorphisms of ACE & eNOS and diabetic nephropathy.	ACE NOS3	6.77e-06	2	91	2	25227524
Pubmed	Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease.	RELN LRP8	6.77e-06	2	91	2	29442527
Pubmed	BUBR1 Insufficiency Is Correlated with eNOS Reduction Experimentally In Vitro and In Vivo, and in Gastric Cancer Tissue.	BUB1B NOS3	6.77e-06	2	91	2	30396924
Pubmed	Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice.	KREMEN2 LRP5	6.77e-06	2	91	2	25061805
Pubmed	High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis.	ACE NOS3	6.77e-06	2	91	2	12015245
Pubmed	Loss of apolipoprotein E receptor LR11 in Alzheimer disease.	LRP8 SORL1	6.77e-06	2	91	2	15313836
Pubmed	eNOS and ACE genes influence peripheral arterial disease predisposition in smokers.	ACE NOS3	6.77e-06	2	91	2	20478683
Pubmed	ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension.	ACE NOS3	6.77e-06	2	91	2	23042814
Pubmed	Association of the genetic polymorphisms of the ACE gene and the eNOS gene with lupus nephropathy in northern Chinese population.	ACE NOS3	6.77e-06	2	91	2	20540812
Pubmed	Angiotensin-converting enzyme and endothelial constitutive nitric oxide synthase polymorphisms in Turkish renal transplant population and possible influence on renal artery atherosclerosis and graft survival.	ACE NOS3	6.77e-06	2	91	2	16213264
Pubmed	Relations between ACE gene and ecNOS gene polymorphisms and resistive index in type 2 diabetic patients with nephropathy.	ACE NOS3	6.77e-06	2	91	2	11522715
Pubmed	Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.	ACE NOS3	6.77e-06	2	91	2	14989558
Pubmed	Endothelial dysfunction in patients with asthma: the role of polymorphisms of ACE and endothelial NOS genes.	ACE NOS3	6.77e-06	2	91	2	15115168
Pubmed	LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.	RELN LRP8	6.77e-06	2	91	2	25892301
Pubmed	How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes.	PKD1 ABCC6	6.77e-06	2	91	2	18791038
Pubmed	Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients.	MPST TST	6.77e-06	2	91	2	19695240
Pubmed	Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with asthma.	ACE NOS3	6.77e-06	2	91	2	11030378
Pubmed	[GENES ALLELE STATUS OF ANGIOTENSINCONVERTING ENZYME (I/D) AND ENDOTHELIAL NITRIC OXIDE SYNTHASE (894 G > T) IN PATIENTS WITH ACUTE CORONARY SYNDROME].	ACE NOS3	6.77e-06	2	91	2	27089712
Pubmed	Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.	ABCC1 ABCC6	6.77e-06	2	91	2	10835642
Pubmed	Association of eNOS and ACE gene polymorphisms and plasma nitric oxide with risk of non-small cell lung cancer in South India.	ACE NOS3	6.77e-06	2	91	2	27328622
Pubmed	A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling.	RELN LRP8	6.77e-06	2	91	2	12426372
Pubmed	Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men.	ACE NOS3	6.77e-06	2	91	2	17563560
Pubmed	Association of eNOS and ACE Polymorphisms with Retinopathy of Prematurity: A Systematic Review and Meta-Analysis.	ACE NOS3	6.77e-06	2	91	2	31437068
Pubmed	Lack of association of NOS3 and ACE gene polymorphisms with coronary artery disease in Southern Tunisia.	ACE NOS3	6.77e-06	2	91	2	23011259
Pubmed	ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction.	ACE NOS3	6.77e-06	2	91	2	12837457
Pubmed	Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter.	ABCC1 ABCC6	6.77e-06	2	91	2	10811882
Pubmed	Aspects of the molecular-genetic profile in patients with ischemic heart disease.	ACE NOS3	6.77e-06	2	91	2	24505896
Pubmed	Amyloid-β-related genes SORL1 and ACE are genetically associated with risk for late-onset Alzheimer disease in the Chinese population.	ACE SORL1	6.77e-06	2	91	2	20625269
Pubmed	Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density.	RELN LRP8	6.77e-06	2	91	2	21852430
Pubmed	Polymorphisms of angiotensin converting enzyme and nitric oxide synthase 3 genes as risk factors of high-altitude pulmonary edema: a case-control study and meta-analysis.	ACE NOS3	6.77e-06	2	91	2	23603420
Pubmed	Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD).	ACE NOS3	6.77e-06	2	91	2	22695028
Pubmed	ACE I allele and eNOS G allele crosstalk may have a role in chronic obstructive pulmonary disease.	ACE NOS3	6.77e-06	2	91	2	15498534
Pubmed	Effects of human endothelial gene polymorphisms on cellular responses to hyperglycaemia: role of NOS3 (Glu298Asp) and ACE (I/D) polymorphisms.	ACE NOS3	6.77e-06	2	91	2	21844127
Pubmed	[The influence of single nucleotide polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme on the course of pregnancy complicated by type 1 diabetes].	ACE NOS3	6.77e-06	2	91	2	24505959
Pubmed	Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schönlein purpura nephritis.	ACE NOS3	6.77e-06	2	91	2	22895845
Pubmed	Structural basis for ligand capture and release by the endocytic receptor ApoER2.	RELN LRP8	6.77e-06	2	91	2	28446613
Pubmed	Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Behçet's disease with or without ocular involvement.	ACE NOS3	6.77e-06	2	91	2	19255721
Pubmed	Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice.	RELN LRP8	6.77e-06	2	91	2	12093079
Pubmed	Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients.	ACE NOS3	6.77e-06	2	91	2	26670794
Pubmed	Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.	ACE NOS3	6.77e-06	2	91	2	24827774
Pubmed	Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.	NOS3 LRP8	6.77e-06	2	91	2	21123944
Pubmed	Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice.	LRP5 NOS3	6.77e-06	2	91	2	22359381
Pubmed	Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population.	ACE NOS3	6.77e-06	2	91	2	15292102
Pubmed	Angiotensin-converting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation.	ACE NOS3	6.77e-06	2	91	2	12687832
Pubmed	Endothelial nitric oxide synthase gene influences the risk of pre-eclampsia, the recurrence of negative pregnancy events, and the maternal-fetal flow.	ACE NOS3	6.77e-06	2	91	2	16915032
Pubmed	[Relations between endothelial nitric oxide synthase and angiotensin-converting gene polymorphisms and certain biochemical parameters in patients with cardiac syndrome X].	ACE NOS3	6.77e-06	2	91	2	15724677
Pubmed	Genetic susceptibility to atrial fibrillation in patients with congestive heart failure.	ACE NOS3	6.77e-06	2	91	2	16818212
Pubmed	Genetic predisposition to breath-hold diving-induced hemoptysis: Preliminary study.	ACE NOS3	6.77e-06	2	91	2	26094307
Pubmed	[Association between angiotensin-converting enzyme and endothelial nitric oxide synthase gene polymorphism and risk of coronary artery disease].	ACE NOS3	6.77e-06	2	91	2	18269824
Pubmed	Angiotensin-converting enzyme (insertion/deletion) and endothelial nitric oxide synthase polymorphisms in patients with systemic lupus erythematosus.	ACE NOS3	6.77e-06	2	91	2	15338496
Pubmed	Association of angiotensin-converting enzyme and endothelial Nitric Oxide synthase gene polymorphisms with vascular disease in ESRD patients in a Chinese population.	ACE NOS3	6.77e-06	2	91	2	18629615
Pubmed	Correlation between common genetic variants and risk factors associated with prediction of cardiovascular diseases in dyslipidemic patients.	ACE NOS3	6.77e-06	2	91	2	21919778
Pubmed	Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with lung cancer.	ACE NOS3	6.77e-06	2	91	2	11361058
Pubmed	LSD1 is required for chromosome segregation during mitosis.	BUB1B KDM1A	2.03e-05	3	91	2	20189264
Pubmed	Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.	RELN LRP8	2.03e-05	3	91	2	23209795
Pubmed	Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.	RELN LRP8	2.03e-05	3	91	2	15987942
Pubmed	Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia.	ACE NOS3	2.03e-05	3	91	2	25181428
Pubmed	Gene polymorphisms predisposing to cardiac hypertrophy in patients with cardiac syndrome X.	ACE NOS3	2.03e-05	3	91	2	19051693
Pubmed	Endothelial constitutive nitric oxide synthase, angiotensin converting enzyme, angiotensin II type 1 receptor gene polymorphisms and endothelial functions in healthy individuals.	ACE NOS3	2.03e-05	3	91	2	24452940
Pubmed	Association of genetic polymorphisms with endothelial dysfunction in chronic heart failure.	ACE NOS3	2.03e-05	3	91	2	24992619
Pubmed	[Angiotensin converting enzyme, NO-synthase, and endothelin-1 genes and left ventricular hypertrophy in natives of Yakutia with hypertensive disease].	ACE NOS3	2.03e-05	3	91	2	15699938
Pubmed	Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse.	RELN LRP8	2.03e-05	3	91	2	18778775
Pubmed	Multi-locus interactions of vascular homeostasis genes in essential hypertension: a gender-based study.	ACE NOS3	2.03e-05	3	91	2	19379721
Pubmed	Endothelial function and germ-line ACE I/D, eNOS and PAI-1 gene profiles in patients with coronary slow flow in the Canakkale population: multiple thrombophilic gene profiles in coronary slow flow.	ACE NOS3	2.03e-05	3	91	2	24435163
Pubmed	Expression and localization of ATP binding cassette (ABC) family of drug transporters in gastric hepatoid adenocarcinomas.	ABCC1 ABCC6	2.03e-05	3	91	2	18439156
Pubmed	Beta-amyloid impairs reelin signaling.	RELN LRP8	2.03e-05	3	91	2	23951306
Pubmed	The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement.	RELN LRP8	2.03e-05	3	91	2	19720620
Pubmed	C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus.	RELN LRP8	2.03e-05	3	91	2	28123028
Pubmed	Correlation analysis of angiotensin-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase gene polymorphisms and the progression of immunoglobulin A nephropathy/membranous nephropathy.	ACE NOS3	2.03e-05	3	91	2	24157068
Pubmed	Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice.	RELN LRP8	2.03e-05	3	91	2	11920707
Pubmed	Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.	RELN LRP8	2.03e-05	3	91	2	19948739
Pubmed	Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11.	ABCC1 ABCC6	2.03e-05	3	91	2	11439001
Pubmed	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.	RELN LRP8	2.03e-05	3	91	2	12670700
Pubmed	ApoER2 and Reelin are expressed in regenerating peripheral nerve and regulate Schwann cell migration by activating the Rac1 GEF protein, Tiam1.	RELN LRP8	2.03e-05	3	91	2	26386179
Pubmed	Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.	RELN LRP8	2.03e-05	3	91	2	15175346
Pubmed	Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function.	ATP2A2 NOS3	2.03e-05	3	91	2	26475037
Pubmed	Polymorphisms in NOS3, ACE and PAI-1 genes and risk of spontaneous recurrent miscarriage in the Gaza Strip.	ACE NOS3	2.03e-05	3	91	2	20134171
Pubmed	Functional importance of covalent homodimer of reelin protein linked via its central region.	RELN LRP8	2.03e-05	3	91	2	21844191
Pubmed	Genetic risk factors for erectile dysfunction and genetic determinants of drug response--on the way to improve drug safety?	ACE NOS3	2.03e-05	3	91	2	12825146
Pubmed	Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1.	RELN LRP8	2.03e-05	3	91	2	23083738
Pubmed	Gene-environment interaction in chronic kidney disease among people with type 2 diabetes from The Malaysian Cohort project: a case-control study.	KCNQ1 NOS3	2.03e-05	3	91	2	32012348
Pubmed	Genetic association study of the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms and the risk to develop erectile dysfunction in a German ED population.	ACE NOS3	2.03e-05	3	91	2	20629643
Pubmed	Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections.	RELN LRP8	2.03e-05	3	91	2	23758727
Pubmed	Targeted ablation of Abcc1 or Abcc3 in Abcc6(-/-) mice does not modify the ectopic mineralization process.	ABCC1 ABCC6	2.03e-05	3	91	2	17845218
Pubmed	OCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and Impairs Reelin-Induced Responses.	RELN LRP8	2.03e-05	3	91	2	39062513
Pubmed	ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.	RELN LRP8	2.03e-05	3	91	2	21976526
Pubmed	Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi.	RELN LRP8	2.03e-05	3	91	2	28255385
Pubmed	Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy.	ACE NOS3	2.03e-05	3	91	2	20186148
Pubmed	[Clinico-genetic aspects of the hypotensive response and regression of left ventricular hypertrophy in arterial hypertension patients].	ACE NOS3	2.03e-05	3	91	2	12469628
Pubmed	Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects.	ACE NOS3	2.03e-05	3	91	2	28865601
Pubmed	ApoER2 processing by presenilin-1 modulates reelin expression.	RELN LRP8	2.03e-05	3	91	2	24344333
Pubmed	[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis].	ACE NOS3	2.03e-05	3	91	2	16078594
Pubmed	Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction.	ACE NOS3	2.03e-05	3	91	2	15784171
Pubmed	Associations between endothelial nitric oxide synthase A/B, angiotensin converting enzyme I/D and serotonin transporter L/S gene polymorphisms with pulmonary hypertension in COPD patients.	ACE NOS3	2.03e-05	3	91	2	24057178
Pubmed	Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes.	ACE NOS3	2.03e-05	3	91	2	21438754
Pubmed	Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke.	ACE NOS3	2.03e-05	3	91	2	15595935
Cytoband	16p13.1	ABCC1 ABCC6	2.33e-05	4	91	2	16p13.1
Cytoband	22q13.1	MPST SUN2 TST	6.62e-04	85	91	3	22q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr22q12	CRYBA4 MPST TST INPP5J	1.26e-03	235	91	4	chr22q12
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	ABCC1 KREMEN2 PKD1 BRICD5 ABCC6	1.63e-03	426	91	5	chr16p13
GeneFamily	Low density lipoprotein receptors	LRP4 LRP5 LRP1B LRP8	7.15e-08	13	59	4	634
GeneFamily	Gemins	GEMIN2 GEMIN5	1.56e-04	6	59	2	1131
GeneFamily	ATP binding cassette subfamily C	ABCC1 ABCC6	7.98e-04	13	59	2	807
GeneFamily	Beta-gamma crystallins	CRYBA1 CRYBA4	1.07e-03	15	59	2	1359
Coexpression	GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_NAIVE_CD4_TCELL_UP	GTF3C2 FDFT1 PKD1 ANKIB1 TEC LRP1B NOS3	5.50e-06	200	89	7	M4323
Drug	CASs	LDHD FDFT1 TST SLC29A2	8.08e-07	19	89	4	CID000126806
Drug	Pluronic	ABCC1 RELN NR0B1 TEC NOS3 ABCC6	1.44e-06	90	89	6	CID000024751
Drug	AC1Q5QTP	ABCC1 ACE NOS3 ABCC6	3.57e-06	27	89	4	CID000071324
Drug	AC1L1J6H	ABCC1 FDFT1 LRP4 ACE LRP1B NOS3 ABCC6 SORL1	4.06e-06	236	89	8	CID000004889
Drug	monatepil	LRP4 ACE LRP1B SORL1	4.81e-06	29	89	4	CID000060810
Drug	AC1L9M2J	ROM1 TAF1L NOS3 KDM1A SLX1A	1.21e-05	76	89	5	CID000448538
Drug	AC1L1XKM	TEC ACE	1.51e-05	2	89	2	CID000011536
Drug	Fosinopril	ABCC1 ACE NOS3	2.04e-05	14	89	3	ctd:D017328
Drug	buthionine sulfoximine	CRYBA1 TYR CRYBA4 ABCC1 NOS3 ABCC6 B3GAT2	3.25e-05	229	89	7	CID000021157
Drug	3',4',5,7-tetrahydroxyflavanone	TYR ABCC1 FDFT1 INPP5J	3.42e-05	47	89	4	CID000011095
Drug	salicylate	CRYBA1 TYR CRYBA4 ABCC1 NOS3 ABCC6 KDM1A SLX1A	4.37e-05	328	89	8	CID000000338
Drug	Apa-sg	ABCC1 FDFT1 ABCC6	5.35e-05	19	89	3	CID000126348
Drug	phenolate	TYR IL1F10 ACER3 SI NOS3 B3GAT2 SLX1A	6.26e-05	254	89	7	CID000000996
Drug	pralatrexate	ABCC1 RELN ABCC6	7.30e-05	21	89	3	CID000148121
Drug	Halt	TYR PKD1 LRP5	7.30e-05	21	89	3	CID000094635
Drug	acetaminophen glucuronide	ABCC1 ABCC6 B3GAT2 SLX1A	8.42e-05	59	89	4	CID000083944
Drug	psoralen derivative	FDFT1 ATP2A2 ABCC6	8.43e-05	22	89	3	CID000434065
Drug	pitavastatin	FDFT1 LRP4 LRP1B NOS3 SORL1	8.56e-05	114	89	5	CID005282451
Drug	5,6-dichlorovanillin	TEC ACE	9.02e-05	4	89	2	CID000028998
Drug	4-chloro-2-methylphenol	TYR ACE	9.02e-05	4	89	2	CID000014855
Drug	fluorexon	ABCC1 ABCC6	9.02e-05	4	89	2	ctd:C007740
Drug	8-azidoadenosine 5'-triphosphate	ABCC1 ABCC6	9.02e-05	4	89	2	ctd:C017040
Drug	DAB sulfinate	MPST TST	9.02e-05	4	89	2	CID000125472
Drug	4,5-dichloroguaiacol	TEC ACE	9.02e-05	4	89	2	CID000017160
Drug	NSC329691	TYR LRP5	9.02e-05	4	89	2	CID000433434
Drug	grepafloxacin glucuronide	ABCC1 ABCC6	9.02e-05	4	89	2	CID000443296
Drug	Thcc	LRP5 PRKCI	9.02e-05	4	89	2	CID000131201
Drug	6-methylpurine-2'-deoxyriboside	MPST ABCC1 SLC29A2 ABCC6	9.60e-05	61	89	4	CID000097184
Disease	gallbladder adenocarcinoma (is_implicated_in)	DDR2 ACE	2.63e-05	3	88	2	DOID:3500 (is_implicated_in)
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	PKD1 LRP5	5.26e-05	4	88	2	DOID:898 (is_implicated_in)
Disease	CD166 antigen measurement	ABCC1 ABCC6	5.26e-05	4	88	2	EFO_0020245
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	5.26e-05	4	88	2	EFO_0020830
Disease	nephritis (is_implicated_in)	ACE NOS3	8.74e-05	5	88	2	DOID:10952 (is_implicated_in)
Disease	polycystic liver disease (implicated_via_orthology)	PKD1 LRP5	1.83e-04	7	88	2	DOID:0050770 (implicated_via_orthology)
Disease	cataract (implicated_via_orthology)	CRYBA1 LIM2 FDFT1	2.00e-04	38	88	3	DOID:83 (implicated_via_orthology)
Disease	Familial Alzheimer Disease (FAD)	RELN ACE NOS3 SORL1	2.33e-04	100	88	4	C0276496
Disease	coronary artery disease (is_implicated_in)	ACE NOS3 ABCC6 LRP8	2.33e-04	100	88	4	DOID:3393 (is_implicated_in)
Disease	Alzheimer's Disease	RELN ACE NOS3 SORL1	2.42e-04	101	88	4	C0002395
Disease	triacylglycerol 51:2 measurement	GTF3C2 BUD13	2.43e-04	8	88	2	EFO_0021483
Disease	X-13684 measurement	MPST ABCC1	2.43e-04	8	88	2	EFO_0800737
Disease	schizophrenia (is_marker_for)	RELN GRIN2D ACE	3.11e-04	44	88	3	DOID:5419 (is_marker_for)
Disease	obstructive sleep apnea (is_implicated_in)	ACE NOS3	4.75e-04	11	88	2	DOID:0050848 (is_implicated_in)
Disease	Oligospermia	NR0B1 NOS3	5.69e-04	12	88	2	C0028960
Disease	mood disorder	RELN SORL1	6.71e-04	13	88	2	EFO_0004247
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 LRP5	7.82e-04	14	88	2	DOID:898 (implicated_via_orthology)
Disease	atrial fibrillation (is_implicated_in)	KCNQ1 ACE	7.82e-04	14	88	2	DOID:0060224 (is_implicated_in)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	ABCC1 ACE LRP1B	8.94e-04	63	88	3	DOID:3083 (is_implicated_in)
Disease	melanoma	TYR MPST ACER3 LRP1B KDM1A	8.95e-04	248	88	5	C0025202
Disease	Pre-Eclampsia	ACE NOS3	1.03e-03	16	88	2	C0032914
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 ACE	1.03e-03	16	88	2	DOID:0110861 (implicated_via_orthology)
Disease	essential hypertension (is_implicated_in)	ATP2A2 NOS3	1.30e-03	18	88	2	DOID:10825 (is_implicated_in)
Disease	stomach cancer (is_implicated_in)	DDR2 ACE LRP1B	1.32e-03	72	88	3	DOID:10534 (is_implicated_in)
Disease	Retinitis pigmentosa	ROM1 SLC7A14 IMPG2	1.43e-03	74	88	3	cv:C0035334
Disease	cystathionine measurement	TEC TEC	1.45e-03	19	88	2	EFO_0010474
Disease	sensorineural hearing loss (implicated_via_orthology)	DNAH9 SLC7A14	1.45e-03	19	88	2	DOID:10003 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SLC13A3 GRIN2D LRP1B NOS3	1.46e-03	163	88	4	DOID:1826 (implicated_via_orthology)
Disease	Disease Exacerbation	ABCC1 COL7A1 ABCC6 KDM1A	1.53e-03	165	88	4	C0235874
Disease	Depressive disorder	RELN PRKCI ACE ATP2A2 NOS3	1.76e-03	289	88	5	C0011581
Disease	fumarate measurement	SLC39A11 SLC13A3	1.78e-03	21	88	2	EFO_0010480
Disease	hypothyroidism (biomarker_via_orthology)	RELN ATP2A2 NOS3	1.78e-03	80	88	3	DOID:1459 (biomarker_via_orthology)
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	ACE NOS3	2.33e-03	24	88	2	DOID:3827 (biomarker_via_orthology)
Disease	cataract (is_implicated_in)	CRYBA1 LIM2	2.73e-03	26	88	2	DOID:83 (is_implicated_in)
Disease	Myocardial Infarction	ACE NOS3 LRP8	2.91e-03	95	88	3	C0027051

Protein segments in the cluster

Peptide	Gene	Start	Entry
GNDPLDVWDRYISWT	BUB1B	71	O60566
DREGYWGPTTSTLDW	ACER3	6	Q9NUN7
FNIWPGYRWDGVDRS	BUD13	576	Q9BRD0
YGGGIWSTWFDRDLT	DNPEP	131	Q9ULA0
GRTPPSRYNFDWWYL	ACE	481	P12821
YWARRAEGESGPLWG	BRICD5	191	Q6PL45
DPGRCYRVTWFTSWS	AICDA	71	Q9GZX7
PRRSFAGGTWDWEYL	ANKIB1	741	Q9P2G1
RWGASFRRGADFDSW	AIDA	11	Q96BJ3
WYEGERLRDGERGWF	ARHGEF26	826	Q96DR7
ASNPVLDAWYGARDW	ACTR5	526	Q9H9F9
VLADRFGSPADSWWR	DHX30	141	Q7L2E3
GRDTQYWAGWYGPRV	FBXO6	236	Q9NRD1
AVDSYFWRQLTWPEG	ALG12	226	Q9BV10
GTYWCGVDTPWLRDF	CD300C	106	Q08708
AWDTYDTDRDGRVGW	RCN3	121	Q96D15
GTPWEAWAGRILYSV	PCDHGA7	21	Q9Y5G6
SGSAFRLEAAAWPGW	IL1F10	106	Q8WWZ1
SGRVEFGSYADALWW	KCNQ1	291	P51787
RGEDYGFSVDWWALG	PRKCI	426	P41743
FLGRRFGDWRFSWSY	LIM2	126	P55344
DPRYGILFWTDWDAN	LRP1B	1386	Q9NZR2
GDAWARIPFAFWARY	MAGED4	666	Q96JG8
WFGERDFTPELGRWL	GEMIN2	201	O14893
WPGYDYVGWRNESAT	DDR2	251	Q16832
EVDGYNAWRDAFWPS	FER1L4	1356	A9Z1Z3
YWTDWGETPRIERAG	LRP5	166	O75197
YWTEWGGKPRIVRAF	LRP5	776	O75197
GVWESVSGLRYAGLW	JPH4	96	Q96JJ6
FWGWGREDDEFYRRI	B4GALT7	221	Q9UBV7
GGREFWPQEVWSRYV	FDFT1	226	P37268
LSWGPYLRFWAGRIA	FAM177B	61	A6PVY3
LWLGEPEGTATDRWY	PEX5	171	P50542
WDISRYGPNSWRSYL	PCED1B	126	Q96HM7
VESWRVGDTAFWRGP	CYB5RL	156	Q6IPT4
LGASRGPRRSWAVWY	KREMEN2	406	Q8NCW0
AGSWFLERRPFWGAK	GDPD2	306	Q9HCC8
RFRWWQPVFSGEDYD	RELN	1196	P78509
EWFAALGLRWYALPA	NOS3	321	P29474
RPGGAWWDRSYFAQR	NR0B1	166	P51843
WWDRSYFAQRPGGKE	NR0B1	171	P51843
APGVWFFRAFSRDSW	SLC37A2	6	Q8TED4
AAWWFIAADGGPRVS	ATP2A2	851	P16615
YLPWWSEESSGRAYR	GLP2R	121	O95838
WRADPWARGSYSYVA	KDM1A	751	O60341
DEWYTRFRVSWDPSP	COL12A1	2126	Q99715
KVVGWYTGWRADRPF	B3GAT2	226	Q9NPZ5
RSATWELFPWRGYCS	LDHD	6	Q86WU2
FILERGEYPRWDAWS	CRYBA1	86	P05813
GEYPRWDAWSGSNAY	CRYBA1	91	P05813
SWDAWGGNTAYPAER	CRYBA4	76	P53673
LWFGRDFFGRRSLLW	ASNSD1	131	Q9NWL6
AWRSVPGATGYRVTW	COL7A1	346	Q02388
TEGTYDLPYWDRAGW	DCBLD2	561	Q96PD2
WARRAYPSTAGLAAW	DNAH9	4306	Q9NYC9
PWDSRWVSGVTGRLY	ERVFC1	146	P60507
WVSGVTGRLYRWPTD	ERVFC1	151	P60507
WISFLYGGLSFRGWR	SLC13A3	296	Q8WWT9
PLRGAGFSTWRAFWY	SLC39A11	251	Q8N1S5
VWLYWRGASSFDPLI	C3orf56	101	Q8N813
WGYDGNDVEFTWLRG	GABRP	181	O00591
AVDPLRGFMYWSDWG	LRP8	546	Q14114
NVSYSWTAWRDRGPA	PKD1	1661	P98161
WADLFYSFWERSRGI	ABCC1	86	P33527
GLALYWGTSRWGAAE	KCNAB3	221	O43448
RPGAEEETIFGSWFW	GPRASP1	571	Q5JY77
FWTDWGDLKPGIYRS	SORL1	891	Q92673
DASDQGLYSAPRVWW	MPST	101	P25325
SPWSAARGVLRNYWE	MRPL32	11	Q9BYC8
DWLGRSLTSYFLWPD	SLC29A2	341	Q14542
DWAYGNDIDARPWDF	STRIP2	746	Q9ULQ0
WWRARDKYGNEGYIP	TEC	216	P42680
RGWFWGYEETRGLNV	POFUT2	176	Q9Y2G5
SFCRGYWLSLWADDP	ABCC6	961	O95255
RVAEWRYGPARLWYD	TAF1L	356	Q8IZX4
WFDDRAWYPLGRIIG	STT3A	71	P46977
YIENLTFGWDGPSWR	SETD4	326	Q9NVD3
SGRVIWDSWLPGFAF	SI	1081	P14410
AVWEAFRTFWDRLPG	IMPG2	116	Q9BZV3
ARSSWDWIGLYRVGF	INPP5J	766	Q15735
TSLDPRRVQWGAAWY	SLC7A14	6	Q8TBB6
WGRSEDKEAWFPASF	SPATA13	186	Q96N96
TSPGRLFRLLYWWAG	SUN2	171	Q9UH99
DWFGVQWVSSRYLDP	ROM1	176	Q03395
DAESWGWDLGRSRLY	SPSB4	136	Q96A44
RAGADSGYAGFWRPW	RIPPLY2	26	Q5TAB7
LYGRLYEFWWSLSRP	GEMIN5	1281	Q8TEQ6
TGDENFTIPYWDWRD	TYR	226	P14679
GFPSSVAALRFEWAW	SLX1A	71	Q9BQ83
RWDVSFFTGGPLWAL	GTF3C2	386	Q8WUA4
VYDGSWSEWFRRAPP	TST	271	Q16762
GTIYWTDWGNTPRIE	LRP4	566	O75096
GNYRELRWFTPWSRS	NADSYN1	121	Q6IA69
EAFRDPIWSTWALYG	MYORG	311	Q6NSJ0
RYWSVDKLGGWRAGS	GRIN2D	1151	O15399