Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainJMJC

HSPBAP1 JMJD1C KDM7A KDM6A

1.03e-04321444PS51184
DomainJmjC_dom

HSPBAP1 JMJD1C KDM7A KDM6A

1.03e-04321444IPR003347
DomainJmjC

HSPBAP1 JMJD1C KDM7A KDM6A

1.17e-04331444SM00558
DomainAgo_hook

TNRC6B TNRC6C

1.76e-0431442PF10427
DomainTNRC6_PABC-bd

TNRC6B TNRC6C

1.76e-0431442IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6C

1.76e-0431442IPR019486
DomainTNRC6-PABC_bdg

TNRC6B TNRC6C

1.76e-0431442PF16608
DomainEGF-like_CS

SELE RELN JAG2 THBS1 HMCN1 MEGF8 CLEC14A VCAN EPHA5

1.95e-042611449IPR013032
DomainEGF_2

SELE RELN JAG2 THBS1 HMCN1 MEGF8 CLEC14A VCAN EPHA5

2.19e-042651449PS01186
DomainPRY

TRIM68 TRIM14 TRIM16 RFPL2

3.02e-04421444PF13765
DomainEGF

SELE RELN JAG2 THBS1 HMCN1 MEGF8 CLEC14A VCAN

4.84e-042351448SM00181
DomainEGF_3

SELE RELN JAG2 THBS1 HMCN1 MEGF8 CLEC14A VCAN

4.84e-042351448PS50026
DomainPRY

TRIM68 TRIM14 TRIM16 RFPL2

5.07e-04481444SM00589
DomainPRY

TRIM68 TRIM14 TRIM16 RFPL2

5.07e-04481444IPR006574
DomainBRCT

NBN LIG3 PAXIP1

6.21e-04221443SM00292
DomainEGF-like_dom

SELE RELN JAG2 THBS1 HMCN1 MEGF8 CLEC14A VCAN

7.07e-042491448IPR000742
Domain-

NBN LIG3 PAXIP1

7.10e-042314433.40.50.10190
DomainPentatricopeptide_repeat

IFT140 PRORP PTCD3

7.10e-04231443IPR002885
DomainJmjC

JMJD1C KDM7A KDM6A

8.07e-04241443PF02373
DomainEGF_1

SELE RELN JAG2 THBS1 HMCN1 MEGF8 CLEC14A VCAN

8.25e-042551448PS00022
DomainAlpha_kinase

ALPK1 ALPK2

8.68e-0461442PF02816
DomainMHCK_EF2_kinase

ALPK1 ALPK2

8.68e-0461442IPR004166
DomainALPHA_KINASE

ALPK1 ALPK2

8.68e-0461442PS51158
DomainAlpha_kinase

ALPK1 ALPK2

8.68e-0461442SM00811
DomainVWF_A

CACNA2D1 CPNE6 HMCN1 ANAPC1 VWA3B

1.02e-03991445IPR002035
DomainBRCT

NBN LIG3 PAXIP1

1.02e-03261443PS50172
DomainASX_HYDROXYL

JAG2 HMCN1 MEGF8 CLEC14A VCAN

1.06e-031001445PS00010
DomainHECT

NEDD4L NEDD4 HERC2

1.15e-03271443PF00632
DomainHECTc

NEDD4L NEDD4 HERC2

1.15e-03271443SM00119
DomainHECT_dom

NEDD4L NEDD4 HERC2

1.15e-03271443IPR000569
DomainHECT

NEDD4L NEDD4 HERC2

1.15e-03271443PS50237
DomainCAMSAP_CH

ASPM CAMSAP1

1.21e-0371442PF11971
DomainCAMSAP_CH

ASPM CAMSAP1

1.21e-0371442IPR022613
DomainBRCT_dom

NBN LIG3 PAXIP1

1.28e-03281443IPR001357
DomainEGF-type_Asp/Asn_hydroxyl_site

JAG2 HMCN1 MEGF8 CLEC14A VCAN

1.38e-031061445IPR000152
DomainBBOX

TRIM68 TRIM14 TRIM16 TRIM66

1.99e-03691444SM00336
DomainButyrophylin

TRIM68 TRIM14 TRIM16 RFPL2

2.10e-03701444IPR003879
Domain-

TRIM68 TRIM14 TRIM16 TRIM66

2.21e-037114444.10.45.10
Domainzf-B_box

TRIM68 TRIM14 TRIM16 TRIM66

2.32e-03721444PF00643
DomainIGc2

MYOM1 FSTL4 NPTN HMCN1 CNTN5 LILRB5 ALPK2

2.34e-032351447SM00408
DomainIg_sub2

MYOM1 FSTL4 NPTN HMCN1 CNTN5 LILRB5 ALPK2

2.34e-032351447IPR003598
DomainCH

LRCH2 ASPM DMD CAMSAP1

2.44e-03731444PS50021
DomainEGF_CA

JAG2 THBS1 HMCN1 MEGF8 VCAN

2.56e-031221445SM00179
Domain-

CACNA2D1 CPNE6 HMCN1 VWA3B

2.57e-037414443.40.50.410
DomainCH-domain

LRCH2 ASPM DMD CAMSAP1

2.70e-03751444IPR001715
DomainEGF-like_Ca-bd_dom

JAG2 THBS1 HMCN1 MEGF8 VCAN

2.75e-031241445IPR001881
DomainCadherin_tail

PCDHGB2 PCDHGA5 PCDHGA12

2.88e-03371443PF15974
DomainCadherin_CBD

PCDHGB2 PCDHGA5 PCDHGA12

2.88e-03371443IPR031904
DomainKinase-like_dom

PDPK1 SNRK ALPK1 ARHGAP35 CIT CDKL5 PTPN13 RPS6KA6 DMD ALPK2 EPHA5

3.23e-0354214411IPR011009
DomainUQ_con

BIRC6 UBE2R2 CDC34

3.35e-03391443PF00179
DomainZF_BBOX

TRIM68 TRIM14 TRIM16 TRIM66

3.41e-03801444PS50119
DomainZnf_B-box

TRIM68 TRIM14 TRIM16 TRIM66

3.56e-03811444IPR000315
DomainIg_I-set

MYOM1 FSTL4 NPTN HMCN1 CNTN5 ALPK2

3.58e-031901446IPR013098
DomainI-set

MYOM1 FSTL4 NPTN HMCN1 CNTN5 ALPK2

3.58e-031901446PF07679
Domainig

MYOM1 FSTL4 NPTN HMCN1 CNTN5 LILRB5

3.58e-031901446PF00047
DomainImmunoglobulin

MYOM1 FSTL4 NPTN HMCN1 CNTN5 LILRB5

3.58e-031901446IPR013151
DomainUBIQUITIN_CONJUGAT_1

BIRC6 UBE2R2 CDC34

3.60e-03401443PS00183
DomainVWFA

CACNA2D1 CPNE6 HMCN1 VWA3B

3.72e-03821444PS50234
DomainUBIQUITIN_CONJUGAT_2

BIRC6 UBE2R2 CDC34

3.86e-03411443PS50127
DomainUBQ-conjugat_E2

BIRC6 UBE2R2 CDC34

3.86e-03411443IPR000608
DomainVWA

CACNA2D1 CPNE6 HMCN1 VWA3B

4.06e-03841444SM00327
DomainCadherin_C

PCDHGB2 PCDHGA5 PCDHGA12

4.14e-03421443IPR032455
DomainCadherin_C_2

PCDHGB2 PCDHGA5 PCDHGA12

4.14e-03421443PF16492
DomainEGF_CA

JAG2 THBS1 HMCN1 MEGF8

4.41e-03861444PF07645
DomainSPRY

TRIM68 TRIM14 TRIM16 RFPL2

4.60e-03871444SM00449
DomainWW

NEDD4L NEDD4 DMD

5.68e-03471443PF00397
DomainWW

NEDD4L NEDD4 DMD

6.02e-03481443SM00456
DomainSPRY

TRIM68 TRIM14 TRIM16 RFPL2

6.05e-03941444PF00622
DomainSPRY_dom

TRIM68 TRIM14 TRIM16 RFPL2

6.05e-03941444IPR003877
DomainB30.2/SPRY

TRIM68 TRIM14 TRIM16 RFPL2

6.27e-03951444IPR001870
DomainB302_SPRY

TRIM68 TRIM14 TRIM16 RFPL2

6.27e-03951444PS50188
DomainEGF_Ca-bd_CS

JAG2 HMCN1 MEGF8 VCAN

6.75e-03971444IPR018097
DomainSANT

NCOR1 ZSCAN20 MTA3

6.75e-03501443SM00717
Domain-

BIRC6 UBE2R2 CDC34

7.13e-035114433.10.110.10
DomainWW_DOMAIN_1

NEDD4L NEDD4 DMD

7.13e-03511443PS01159
DomainWW_DOMAIN_2

NEDD4L NEDD4 DMD

7.13e-03511443PS50020
DomainEGF_CA

JAG2 HMCN1 MEGF8 VCAN

7.25e-03991444PS01187
DomainWW_dom

NEDD4L NEDD4 DMD

7.53e-03521443IPR001202
DomainSANT/Myb

NCOR1 ZSCAN20 MTA3

7.53e-03521443IPR001005
PathwayKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS

NEDD4L BIRC6 NEDD4 UBE2R2 ANAPC1 HERC2 CDC34

3.71e-05135967M15247
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA2D1 NEDD4L LRCH2 ARHGEF12 TNRC6B CIT NEDD4 ZNF462 NCOR1 NPTN CCDC13 LMNB1 ANAPC1 NAV1 HERC2 BSN CAMSAP1 PRRC2B

2.02e-079631501828671696
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ALPK1 ARHGAP35 TRIM14 BIRC6 FCHO1 JMJD1C EPN2 ZNF462 HIVEP3 TRIM66 MORC3 PRORP PREX1

2.50e-074931501315368895
Pubmed

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.

NEDD4L NEDD4 THBS1

3.14e-074150320026598
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TNRC6B SNRK ALPK1 TNRC6C ARHGAP35 BIRC6 ZNF462 CAMTA1 PREX1

6.37e-07225150912168954
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CACNA2D1 NEDD4L LRCH2 ARHGEF12 KIAA1549 APOE ARHGAP35 CIT EPN2 CDKL5 NPTN CPNE6 SLC24A2 VCAN NAV1 USP4 DMD BSN KNG1 PRRC2B PTCD3

9.74e-0714311502137142655
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

TMEM201 PDPK1 UBXN6 ERGIC2 FCHO1 ZRANB3 EPN2 NPTN GTF2I USP4 MORC3 HERC2

1.32e-064811501228190767
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MBTPS1 NEDD4L LRCH2 ARHGEF12 TNRC6B TNRC6C NEDD4 MEGF8 NAV1 CAMTA1 PRRC2B

1.71e-064071501112693553
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZGRF1 TNRC6B BIRC6 JMJD1C ZNF462 NCOR1 PTPN13 GTF2I ANAPC1 NAV1 CAMSAP1

2.22e-064181501134709266
Pubmed

Human transcription factor protein interaction networks.

TNRC6B NBN TNRC6C FIGN CIT JMJD1C SFXN1 ZNF462 NCOR1 LIG3 HOXB9 GTF2I MTA3 RECQL5 PAXIP1 HERC2 DDX24 KDM6A PRRC2B PTCD3

3.69e-0614291502035140242
Pubmed

Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.

RELN NEDD4L NEDD4

4.33e-068150324036464
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TNRC6B NBN APOE ARHGAP35 JMJD1C NCOR1 PTPN13 GTF2I LMNB1 ANAPC1 KDM6A PRRC2B

5.10e-065491501238280479
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

IFT140 LRCH2 UBE2R2 PTPN13 GTF2I NAV1 CDC34 DUSP11

8.10e-06232150825515538
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

FOXM1 ZGRF1 E2F7 NBN NCOR1 ANAPC1 RECQL5 ASPM NAV1 MORC3 BSN PRRC2B

1.01e-055881501238580884
Pubmed

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.

RAG1 TRIM14 NLRP3

1.26e-0511150331999304
Pubmed

Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.

TNRC6B NEDD4 SFXN1 TTI1 MUTYH

1.77e-0574150523604909
Pubmed

E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.

SELE APOE

1.85e-052150227470513
Pubmed

E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation.

SELE NLRP3

1.85e-052150237903858
Pubmed

Reelin Plasma Levels Identify Cognitive Decline in Alcohol Use Disorder Patients During Early Abstinence: The Influence of APOE4 Expression.

RELN APOE

1.85e-052150237350760
Pubmed

Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles.

VCAN DMD

1.85e-052150232632164
Pubmed

Cleavage of the carboxyl tail from the G3 domain of aggrecan but not versican and identification of the amino acids involved in the degradation.

ACAN VCAN

1.85e-052150211932252
Pubmed

Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.

RAG1 THBS1

1.85e-052150224590059
Pubmed

Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk.

RELN APOE

1.85e-052150217621165
Pubmed

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

NEDD4L NEDD4

1.85e-052150237962894
Pubmed

NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.

APOE NLRP3

1.85e-052150228596375
Pubmed

A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse.

APOE THBS1

1.85e-052150225524772
Pubmed

Inhibitory role of IFN-gamma-inducible lysosomal thiol reductase in T cell activation.

RAG1 IFI30

1.85e-052150216982871
Pubmed

Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

NEDD4L NEDD4

1.85e-052150223262292
Pubmed

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.

FOXM1 NBN

1.85e-052150224141789
Pubmed

Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice.

APOE THBS1

1.85e-052150218818405
Pubmed

Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

1.85e-052150219602703
Pubmed

Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome.

FPR1 NLRP3

1.85e-052150232244997
Pubmed

Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice.

APOE THBS1

1.85e-052150225803585
Pubmed

ASPM and citron kinase co-localize to the midbody ring during cytokinesis.

CIT ASPM

1.85e-052150217534152
Pubmed

Inhibition of lipoprotein-associated phospholipase A2 ameliorates inflammation and decreases atherosclerotic plaque formation in ApoE-deficient mice.

PLA2G7 APOE

1.85e-052150221909350
Pubmed

FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes.

FOXM1 NEDD4

1.85e-052150220332230
Pubmed

Identification and characterization of versican/PG-M aggregates in cartilage.

ACAN VCAN

1.85e-052150216648631
Pubmed

Embryonic expression and regulation of the large zinc finger protein KRC.

RAG1 HIVEP3

1.85e-052150212001065
Pubmed

Relationship of late arteriovenous fistula stenosis with soluble E-selectin and soluble EPCR in chronic hemodialysis patients with arteriovenous fistula.

SELE PROCR

1.85e-052150224627030
Pubmed

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

NEDD4L NEDD4

1.85e-052150211149908
Pubmed

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice.

NEDD4L NEDD4

1.85e-052150231802037
Pubmed

Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk.

PLA2G7 APOE

1.85e-052150222632920
Pubmed

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice.

APOE NLRP3

1.85e-052150228394319
Pubmed

Expression of thrombospondin 1 on the surface of activated platelets mediates their interaction with the heavy chains of human kininogens through Lys 244-Pro 254.

THBS1 KNG1

1.85e-05215029459346
Pubmed

Aberrant ASPM expression mediated by transcriptional regulation of FoxM1 promotes the progression of gliomas.

FOXM1 ASPM

1.85e-052150232667745
Pubmed

Regulation of lipoprotein-associated phospholipase A2 silencing on myocardial fibrosis in mice with coronary atherosclerosis.

PLA2G7 APOE

1.85e-052150231053299
Pubmed

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation.

NEDD4L NEDD4

1.85e-052150211502596
Pubmed

HMGB1-Neutralizing IgM Antibody Is a Normal Component of Blood Plasma.

RAG1 APOE

1.85e-052150232522835
Pubmed

Functional Analysis of RELN S2486G Mutation and its Contribution to Pathogenesis of Ankylosing Spondylitis.

PLA2G7 RELN

1.85e-052150233107310
Pubmed

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.

APOE NLRP3

1.85e-052150221451572
Pubmed

Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus.

APOE NLRP3

1.85e-052150228708885
Pubmed

An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen.

RAG1 IFI30

1.85e-052150225875653
Pubmed

Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.

APOE NLRP3

1.85e-052150225613820
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NEDD4L ATG2A ZRANB3 NEDD4 NCOR1 ARHGAP31 INAVA CAMTA1 BSN CAMSAP1

1.89e-054301501035044719
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

CACNA2D1 E2F7 FIGN TG PTPN13 SLC24A2 IFI30 CDC34

2.12e-05265150819240061
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

NOL6 NBN SEC31B NCOR1 LIG3 THBS1 MEGF8 PAXIP1 BSN KDM6A PREX1 PRRC2B

2.27e-056381501231182584
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

NEDD4L TNRC6B JMJD1C EPN2 NEDD4 SFXN1 ZNF462 NCOR1 TTI1 CAMTA1 MUTYH

2.28e-055361501115840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

NEDD4L TNRC6B JMJD1C EPN2 NEDD4 SFXN1 ZNF462 NCOR1 TTI1 CAMTA1 MUTYH

2.36e-055381501110512203
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX3 ATG2A TNRC6C ARHGAP35 BIRC6 CIT JAG2 HIVEP3 NCOR1 MEGF8 PAXIP1 NAV1 HERC2 CAMSAP1 PREX1 PRRC2B

2.47e-0511051501635748872
Pubmed

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

RELN DNAI1 LMNB1

2.76e-0514150319874786
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

MYOM1 ARHGEF12 EPS8L1 FCHO1 JMJD1C LMNB1 CAMSAP1 C1orf94 PRRC2B

2.91e-05361150926167880
Pubmed

Genetic dissection of plexin signaling in vivo.

RELN ARHGEF12 ACAN

3.44e-0515150324469813
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

NOL6 TNRC6B BIRC6 SFXN1 CDKL5 NCOR1 PTPN13 GTF2I LMNB1 TOMM34 CAMSAP1 PRRC2B PTCD3

3.46e-057771501335844135
Pubmed

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

NEDD4L BIRC6 NEDD4 UBE2R2 CDC34

4.10e-0588150527182664
Pubmed

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

NEDD4L HERC2 CDC34

4.23e-0516150322496338
Pubmed

The HSP90 family of genes in the human genome: insights into their divergence and evolution.

HSP90AB4P HSP90AA5P HSP90AA2P

4.23e-0516150316269234
Pubmed

A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.

USP4 INAVA BSN

4.23e-0516150325082827
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

EGLN2 RELN TRIM68 APOE SEC31B CIT TRIM66 ZBTB44 CCDC13 THBS1 PTPN13 MTA3 PPP5C MORC3 HERC2 KDM6A PREX1

4.24e-0512851501735914814
Pubmed

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

NEDD4L NEDD4

5.53e-053150218498246
Pubmed

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

NEDD4L NEDD4

5.53e-053150221852580
Pubmed

Link protein has greater affinity for versican than aggrecan.

ACAN VCAN

5.53e-053150214724283
Pubmed

Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.

ACAN VCAN

5.53e-053150219669783
Pubmed

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.

KDM7A KDM6A

5.53e-053150232125007
Pubmed

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

NEDD4L NEDD4

5.53e-053150220730100
Pubmed

GILT in Thymic Epithelial Cells Facilitates Central CD4 T Cell Tolerance to a Tissue-Restricted, Melanoma-Associated Self-Antigen.

RAG1 IFI30

5.53e-053150232269095
Pubmed

NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis.

NLRP3 NEDD4

5.53e-053150236732831
Pubmed

THBS1/CD47 Modulates the Interaction of γ-Catenin With E-Cadherin and Participates in Epithelial-Mesenchymal Transformation in Lipid Nephrotoxicity.

APOE THBS1

5.53e-053150233681182
Pubmed

T cell requirement for development of chronic ulcerative dermatitis in E- and P-selectin-deficient mice.

SELE RAG1

5.53e-053150212391189
Pubmed

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent.

RAG1 APOE

5.53e-053150216682495
Pubmed

The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.

NEDD4L NEDD4

5.53e-053150222361880
Pubmed

Distinct interaction of versican/PG-M with hyaluronan and link protein.

ACAN VCAN

5.53e-053150212888576
Pubmed

Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C.

NEDD4L NEDD4

5.53e-053150219423771
Pubmed

A mechanosensitive transcriptional mechanism that controls angiogenesis.

ARHGAP35 GTF2I

5.53e-053150219242469
Pubmed

In situ hybridization and immunohistochemistry of versican, aggrecan and link protein, and histochemistry of hyaluronan in the developing mouse limb bud cartilage.

ACAN VCAN

5.53e-053150214620382
Pubmed

Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.

RELN THBS1

5.53e-053150238147128
Pubmed

Pleiotropy of ABO gene: correlation of rs644234 with E-selectin and lipid levels.

SELE APOE

5.53e-053150229373315
Pubmed

An essential role for Rab27a GTPase in eosinophil exocytosis.

RAG1 THBS1

5.53e-053150223986549
Pubmed

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.

ACAN VCAN

5.53e-053150229515038
Pubmed

Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.

RELN APOE

5.53e-053150235977442
Pubmed

Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.

NEDD4L NEDD4

5.53e-053150211779188
Pubmed

METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression.

FOXM1 PTPN13

5.53e-053150238967523
Pubmed

Increased Susceptibility to Ischemic Brain Injury in Neuroplastin 65-Deficient Mice Likely via Glutamate Excitotoxicity.

NPTN ACAN

5.53e-053150228469561
Pubmed

Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

TNRC6B TNRC6C

5.53e-053150216880270
Pubmed

14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.

NEDD4L NEDD4

5.53e-053150215677482
Pubmed

TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.

NLRP3 TRIM16

5.53e-053150236208489
Pubmed

Carboxypeptidase N: a pleiotropic regulator of inflammation.

CPN1 KNG1

5.53e-053150214687935
Pubmed

FOXM1-activated SIRT4 inhibits NF-κB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy.

FOXM1 NLRP3

5.53e-053150234626587
Pubmed

Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling.

APOE EPN2

5.53e-053150234440686
Pubmed

Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.

NEDD4L NEDD4

5.53e-053150215217910
Pubmed

Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides.

ACAN VCAN

5.53e-053150215590670
Pubmed

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

NEDD4L NEDD4

5.53e-053150212050153
InteractionMAP3K6 interactions

HSP90AB4P UBXN6 ERGIC2 HSP90AA5P ASPM USP4

1.72e-06511456int:MAP3K6
InteractionARL16 interactions

NOL6 TNRC6B BIRC6 SFXN1 NCOR1 GTF2I PRRC2B

2.27e-06831457int:ARL16
InteractionFCSK interactions

FPR1 UBXN6 TRIM66 NPTN PPP5C

1.39e-05431455int:FCSK
InteractionSGK2 interactions

NEDD4L HSP90AB4P PDPK1 HSP90AA5P NEDD4

1.39e-05431455int:SGK2
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

ACAN VCAN

1.77e-044992574
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

MYOM1 FSTL4 NPTN HMCN1 CNTN5 ALPK2

2.57e-04161996593
GeneFamilyPHD finger proteins|Lysine demethylases

JMJD1C KDM7A KDM6A

2.96e-0424993485
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B TNRC6C PAXIP1

3.36e-0425993775
GeneFamilyUbiquitin conjugating enzymes E2

BIRC6 UBE2R2 CDC34

1.46e-0341993102
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SELE ACAN VCAN

1.46e-03419931298
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM68 TRIM14 TRIM16 TRIM66

1.84e-039599459
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

LIG3 BSN

2.98e-031599226
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

NCOR1 ZSCAN20 MTA3

3.06e-0353993532
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SELE ACAN VCAN

3.76e-03579931179
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

HERC2 DMD

4.29e-031899291
GeneFamilyClustered protocadherins

PCDHGB2 PCDHGA5 PCDHGA12

5.21e-036499320
CoexpressionGSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN

IFT140 FSTL4 TNRC6C NCOR1 HMCN1 PAXIP1 NAV1 VWA3B

4.62e-061661478M6826
CoexpressionZHU_CMV_ALL_DN

APOE THBS1 PTPN13 ANAPC1 VCAN USP4 ENG

5.01e-061191477M14555
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

RELN NEDD4L ADGRB1 ARHGEF12 KIAA1549 TNRC6C ARHGAP35 SEC31B JAG2 ZNF462 HIVEP3 CDRT4 SLC24A2 VCAN CNTN5 NAV1 CAMTA1 BSN PRRC2B

1.44e-05110614719M39071
CoexpressionGSE13484_UNSTIM_VS_3H_YF17D_VACCINE_STIM_PBMC_DN

PROCR NBN SFXN1 HIVEP3 ZSCAN32 THBS1 GTF2I LMNB1

1.80e-052001478M3260
CoexpressionGSE22432_UNTREATED_VS_TGFB1_TREATED_COMMON_DC_PROGENITOR_DN

ZRANB3 NEDD4 CPNE6 MTA3 RECQL5 KDM7A HERC2 PREX1

1.80e-052001478M7828
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

CACNA2D1 MBTPS1 TNRC6B BIRC6 LIG3 THBS1 GTF2I LMNB1 ANAPC1 VCAN HERC2 CAMSAP1

9.65e-0638514012gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

CACNA2D1 MBTPS1 BIRC6 LIG3 GTF2I LMNB1 ANAPC1 VCAN CAMSAP1 PRRC2B

4.33e-0531214010gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlaskidney_adult_Mesangium_Meis_top-relative-expression-ranked_1000

CACNA2D1 MYOM1 ARHGEF12 SNRK ALPK1 APOE ARHGAP35 FIGN EPN2 NPTN THBS1 PTPN13 ARHGAP31 CLEC14A DMD DSEL ENG

6.28e-0587214017gudmap_kidney_adult_Mesangium_Meis_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500

CACNA2D1 MBTPS1 TNRC6B BIRC6 LIG3 GTF2I ANAPC1 VCAN

7.57e-052091408gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

CACNA2D1 MBTPS1 TNRC6B SNRK BIRC6 ZNF462 LIG3 THBS1 GTF2I LMNB1 ANAPC1 VCAN HERC2 CAMSAP1 ENG EPHA5

1.01e-0481814016gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_500

PLA2G7 CACNA2D1 RELN LRCH2 E2F7 KIAA1549 TNRC6C FIGN NCOR1 ANAPC1 KNG1

1.12e-0442114011gudmap_developingKidney_e15.5_Peripheral blastema_500
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Myeloid-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 MGAM HSPBAP1 FPR1 NLRP3 LMNB1 KDM7A OSCP1

8.41e-0816514887f293f64e7df7710b13016937cdd4f1af326f8c3
ToppCellfacs-Lung-Endomucin-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE PLA2G7 RAG1 MGAM FPR1 NLRP3 THBS1 LMNB1

8.81e-0816614885126d8f02314717eed341d867856fd4fe16c5118
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE PLA2G7 RAG1 MGAM FPR1 NLRP3 THBS1 LMNB1

8.81e-0816614883037bdca38c3a65eacfa644219cc43c54e303749
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXM1 CACNA2D1 KIAA1549 JAG2 SLC24A2 PAXIP1 TTI1 BSN

1.27e-071741488f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FPR1 JMJD1C THBS1 VCAN CNTN5 IFI30 NAV1 KDM7A

2.11e-07186148823b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN NEDD4 HIVEP3 SLC24A2 ARHGAP31 NAV1 ENG

2.58e-071911488f663131a4810584c5854bd64ee7991a237b7707f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN NEDD4 HIVEP3 SLC24A2 ARHGAP31 NAV1 ENG

2.91e-071941488fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCell(2)_Mono_macro|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

PLA2G7 FPR1 NLRP3 THBS1 VCAN IFI30 PREX1 LILRB5

2.91e-0719414887c05525614ee8cdfcbf22cce9146a8e73af7d14e
ToppCell(6)_Macrophage|World / shred on Cell_type and subtype

PLA2G7 FPR1 APOE THBS1 VCAN IFI30 ENG LILRB5

3.27e-071971488010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCellTransverse-Macrophage-Macrophage|Transverse / Region, Cell class and subclass

PLA2G7 FPR1 NLRP3 THBS1 VCAN IFI30 ENG LILRB5

3.67e-07200148817548806ba38008050244151d1216c69ef8a8310
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLA2G7 FPR1 NLRP3 UBE2R2 THBS1 VCAN IFI30 CAMSAP1

3.67e-0720014889e8659bbc6547f1ab7f4e0a81b0bcbe158e9e2f7
ToppCellTransverse-(6)_Macrophage|Transverse / shred on region, Cell_type, and subtype

PLA2G7 FPR1 NLRP3 THBS1 VCAN IFI30 ENG LILRB5

3.67e-072001488b28350de555fa756d2631f004f71d5ac69b1affe
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLA2G7 FPR1 NLRP3 UBE2R2 THBS1 VCAN IFI30 CAMSAP1

3.67e-07200148887c7c59632a8e9a7a11642f439cb700fb75bb282
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

NEDD4L TNRC6B TNRC6C UBE2R2 GTF2I MEGF8 NAV1 PRRC2B

3.67e-072001488c92e4fc0442404481fcac623d691dae6215b852d
ToppCellTransverse-Macrophage|Transverse / Region, Cell class and subclass

PLA2G7 FPR1 NLRP3 THBS1 VCAN IFI30 ENG LILRB5

3.67e-0720014881920605e5811938814d02b971069a4506868db5f
ToppCellTransverse-(6)_Macrophage-(60)_Macrophage|Transverse / shred on region, Cell_type, and subtype

PLA2G7 FPR1 NLRP3 THBS1 VCAN IFI30 ENG LILRB5

3.67e-0720014882be675684a2958ea609939bb45248bede78a26bc
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXM1 ZGRF1 E2F7 CIT LMNB1 ASPM VWA3B

1.94e-06174148772df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXM1 ZGRF1 E2F7 CIT LMNB1 ASPM VWA3B

1.94e-061741487c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZGRF1 METTL4 FIGN CFAP77 CLEC14A NAV1 ENG

2.52e-061811487fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellCiliated_cells-B-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

EPS8L1 CFAP65 DNAI1 CFAP77 CNTN5 VWA3B OSCP1

2.61e-061821487e44c4810dc7d51a76b86d7623f8e4c4d8b4bf2fc
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE PROCR THBS1 HMCN1 ARHGAP31 CLEC14A ENG

2.61e-0618214873b4dbf61ca0fe50efe05449815630e301cb76630
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE PROCR THBS1 HMCN1 ARHGAP31 CLEC14A ENG

2.61e-061821487ab5761bf9af439231cd0f487b6467e372672a517
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRCH2 FPR1 APOE FIGN PAXIP1 NAV1 CAMSAP1

2.71e-0618314875377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM RELN FIGN HMCN1 SLC24A2 DMD EPHA5

2.81e-0618414872cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM RELN FIGN HMCN1 SLC24A2 DMD EPHA5

2.81e-061841487ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM RELN FIGN HMCN1 SLC24A2 DMD EPHA5

2.81e-0618414872b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellEndothelial-D_(cycle)|World / shred on cell class and cell subclass (v4)

FOXM1 E2F7 CIT LMNB1 CLEC14A ASPM ENG

3.59e-06191148749a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCellLPS-IL1RA-Unknown-Endothelial-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELN TRIM68 CIT SLC26A8 DPEP3 ASPM

3.89e-0612514862938a1d62afe1e0a3abba5eb92f07b886cc0accd
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGEF12 SNRK NEDD4 ARHGAP31 CLEC14A NAV1 ENG

3.98e-06194148743f92b0533e26633dc94cce554045d641ef8fd76
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGEF12 SNRK NEDD4 ARHGAP31 CLEC14A NAV1 ENG

3.98e-0619414871d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN NEDD4 SLC24A2 ARHGAP31 CLEC14A ENG

3.98e-061941487ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SELE SNRK NEDD4 ARHGAP31 CLEC14A NAV1 ENG

4.12e-06195148756efeb58df19f357d7d5ce87348d4f196a595421
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNRK EPN2 HMCN1 ARHGAP31 CLEC14A NAV1 ENG

4.12e-06195148712ba6d95e42d06b1991b011043c0e3370a7b4131
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PROCR JAG2 ARHGAP31 CLEC14A NAV1 ENG PREX1

4.12e-06195148777e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellmedial-2-Hematologic-Classical_Monocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 NLRP3 THBS1 LMNB1 VCAN IFI30

4.40e-061971487fbff79d6ece1605126ae0caa0c71253ea557779c
ToppCellmedial-Hematologic-Classical_Monocyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 NLRP3 THBS1 LMNB1 VCAN IFI30

4.40e-0619714873960eac4b6753e3294e13901f6ea13d894275c8d
ToppCellmedial-Hematologic-Interstitial_Macrophage-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 APOE NLRP3 VCAN IFI30 LILRB5

4.40e-061971487b90c8a41e99c87b46be699d03cd49c97a2ad51af
ToppCellmedial-Hematologic-Classical_Monocyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 NLRP3 THBS1 LMNB1 VCAN IFI30

4.40e-061971487ae2b51d4e91126ee0a0f69c040297c2a78ce27dd
ToppCellNS-moderate-d_07-13-Myeloid-Non-resident_Macrophage|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PLA2G7 FPR1 NLRP3 THBS1 VCAN IFI30 ENG

4.40e-061971487774a5053f43ac7d614c127ae7363d32a3a194f63
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FOXM1 E2F7 CFAP65 DNAI1 SLC26A8 CFAP77 CNTN5

4.40e-0619714876e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCellmedial-Hematologic-Interstitial_Macrophage|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 APOE NLRP3 VCAN IFI30 LILRB5

4.40e-06197148713aec816e21754eac590a12c3a9c795c41108277
ToppCellmedial-2-Hematologic-Interstitial_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 APOE NLRP3 VCAN IFI30 LILRB5

4.40e-06197148738a74eeb2a4c8d6a86b133f02f4e6c641f16a3ac
ToppCelldistal-2-Hematologic-Interstitial_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 APOE NLRP3 VCAN IFI30 LILRB5

4.70e-061991487d4caf296b6ce22a10b78d0efd4e018d867ccb78a
ToppCelldistal-Hematologic-Interstitial_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLA2G7 FPR1 APOE NLRP3 VCAN IFI30 LILRB5

4.70e-061991487e25a67a196f226b60b4aa0ff0cf4471d66333445
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SELE PROCR ARHGEF12 JAG2 LIG3 HMCN1 CLEC14A

4.70e-061991487d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SELE PROCR ARHGEF12 JAG2 LIG3 HMCN1 CLEC14A

4.70e-061991487cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IFT140 FSTL4 SNRK NEDD4 NAV1 ENG PREX1

4.70e-061991487dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLA2G7 FPR1 NLRP3 UBE2R2 VCAN IFI30 CAMSAP1

4.70e-061991487c40cb51c738b15d2761a50cfc8415a31a673be7f
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

KIAA1549 ZBTB44 UBE2R2 PTPN13 VCAN NAV1 DMD

4.70e-061991487358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PLA2G7 FPR1 APOE NLRP3 IFI30 PREX1 LILRB5

4.86e-0620014871438b84096de9b4abe9e6213caa07f6bdff67358
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PLA2G7 FPR1 APOE NLRP3 THBS1 VCAN IFI30

4.86e-06200148709bac15df511687ff336c1e7a67d980c6c281f79
ToppCell(60)_Macrophage|World / shred on Cell_type and subtype

PLA2G7 FPR1 APOE VCAN IFI30 ENG LILRB5

5.53e-06204148706d0cb306f1ad0014d81f8228868938e48c2bcf3
ToppCellEndothelial-H_(cycle)|World / shred on cell class and cell subclass (v4)

FOXM1 CPNE6 LMNB1 CLEC14A ASPM ENG

5.56e-0613314868e3005114761feee028c496cc739e607b35d7831
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXM1 ZGRF1 E2F7 CIT SFXN1 ASPM

5.81e-0613414864d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOE FIGN ACAN ASPM ACSF3 KNG1

6.88e-061381486c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLA2G7 FPR1 NLRP3 THBS1 KDM7A MORC3

8.78e-0614414861efa434e577d1f87e02df01667782f414d63bd60
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLA2G7 FPR1 NLRP3 THBS1 KDM7A MORC3

8.78e-061441486c0c5f254a960ba5e5f1354599d54e77360e6c2ac
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

FPR1 NLRP3 THBS1 VCAN IFI30 INCA1

1.03e-051481486de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 FPR1 ADGRB1 NLRP3 LMNB1 KDM7A

1.49e-051581486d43b335e6aa12d84a75b988fbd6127ff1f4af25c
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 FPR1 ADGRB1 NLRP3 LMNB1 KDM7A

1.49e-051581486ab12b29ce51ca2fcac469cc932391217d97145f9
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXM1 ZGRF1 E2F7 CIT LMNB1 ASPM

1.78e-0516314865285318c52aa31c9b22dc2ffff078e32e408604d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FOXM1 ZGRF1 E2F7 LMNB1 ACAN ASPM

1.90e-051651486eec2d327c94832d1390314c93ef6a2be4648478b
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-7|TCGA-Kidney / Sample_Type by Project: Shred V9

IFT140 RELN CFAP65 DNAI1 CCDC13 INCA1

1.97e-051661486b545de32578047c9ca422354b8992f2d9c9e1cc7
ToppCellCTRL-Myeloid-Monocyte|CTRL / Disease state, Lineage and Cell class

MGAM FPR1 NLRP3 LMNB1 VCAN KDM7A

2.11e-05168148613dca90c7b811e4d5e8fa44f5e892e29be9787a6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRCH2 PROCR JAG2 ARHGAP31 NAV1 ENG

2.18e-051691486c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXM1 ZGRF1 E2F7 CIT LMNB1 ASPM

2.18e-051691486e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM201 NOL6 SEC31B TG TRIM66 HMCN1

2.41e-05172148680b565f6e37f38629f4cf89d5b053b3b8517244e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA2D1 RELN NEDD4 SLC24A2 ARHGAP31 ENG

2.41e-051721486c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCelldroplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE THBS1 HMCN1 ARHGAP31 CLEC14A ENG

2.74e-051761486eb63eb2c301e785196ccadac74a2940b2c524c62
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APOE JMJD1C NEDD4 HMCN1 DMD KDM6A

2.74e-051761486749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

THBS1 HMCN1 PCDHGA12 ARHGAP31 VCAN ALPK2

2.92e-051781486142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PROCR HMCN1 ARHGAP31 CLEC14A B4GALNT3 ENG

2.92e-051781486ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PROCR HMCN1 ARHGAP31 CLEC14A B4GALNT3 ENG

2.92e-051781486ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PROCR HMCN1 ARHGAP31 CLEC14A B4GALNT3 ENG

2.92e-05178148687b04753650e45f12299c8456fb980d6c0d5961c
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FPR1 NLRP3 THBS1 VCAN IFI30 LILRB5

3.11e-05180148666c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCellLPS-IL1RA-Endothelial-Endothelial-FOXM1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXM1 ZGRF1 E2F7 CIT LMNB1 ASPM

3.11e-051801486334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

E2F7 CFAP65 DNAI1 CCDC13 CFAP77 VWA3B

3.20e-051811486dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELE SNRK JAG2 HMCN1 CLEC14A ENG

3.30e-051821486d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNRK FIGN CFAP77 PCDHGA12 CLEC14A ENG

3.41e-051831486709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNRK FIGN CFAP77 PCDHGA12 CLEC14A ENG

3.41e-051831486dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCellfacs-Pancreas-Exocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HOXB9 HMCN1 ARHGAP31 CLEC14A ENG

3.41e-051831486c9d9d7dd629ce6787502103b158a07e8684a66f8
ToppCellfacs-Pancreas-Exocrine-18m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HOXB9 HMCN1 ARHGAP31 CLEC14A ENG

3.41e-051831486c7ef8ee2b3fcfa69cea0fdcb2041674b832933db
ToppCell3'_v3-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

FPR1 CFAP65 THBS1 LMNB1 VCAN IFI30

3.41e-051831486f10e72a2e2e6cdc1984f469a60244e5fd8a10095
ToppCellfacs-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HOXB9 HMCN1 ARHGAP31 CLEC14A ENG

3.41e-05183148692eee4bdd84965ae0bd1ed1c7f26a3b83ad0cdac
ToppCellnormal_Lymph_Node-Myeloid_cells-Monocytes|normal_Lymph_Node / Location, Cell class and cell subclass

FPR1 NLRP3 CCDC13 THBS1 VCAN IFI30

3.51e-0518414863cec28ff076fa53d034428de2bb1a237e0c1568c
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGA5 DNAI1 ARHGAP31 CLEC14A NAV1 ENG

3.62e-051851486742350093d90f96735dc73e3360cdd749bae63fd
ToppCellfacs-Trachea-nan-24m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SNRK JAG2 ARHGAP31 CLEC14A ENG

3.62e-051851486dec60254204014083ff3b4aec0cc75410950a486
ToppCellwk_08-11-Hematologic-Myeloid-APOE+_Mac2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TCP10L PLA2G7 DPEP3 IFI30 PREX1 LILRB5

3.62e-0518514868f843badc0e26cb7300c83db56c7974beb90fcf3
ToppCellfacs-Trachea-nan-24m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SNRK JAG2 ARHGAP31 CLEC14A ENG

3.62e-051851486201465dc0d7aa0336a36d37805cae1155a5adfe1
ToppCellfacs-Trachea-nan-24m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SNRK JAG2 ARHGAP31 CLEC14A ENG

3.62e-051851486334f006c3ef33338ff8d649309d3f448733a3a99
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXM1 RAG1 PCDHGB2 E2F7 LMNB1 ASPM

3.73e-0518614863993f1ef8a33b8a75dfd3db8d4845b5afbb0bb3d
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ALPK1 APOE THBS1 VCAN CAMSAP1 LILRB5

3.73e-051861486f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCellDividing_Macrophages-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FOXM1 E2F7 HOXB9 LMNB1 SLC22A10 ASPM

3.73e-0518614860067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXM1 RAG1 PCDHGB2 E2F7 LMNB1 ASPM

3.73e-051861486ec6d0c29e196e374baa96dd3d506f489c959e77e
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ALPK1 APOE THBS1 VCAN CAMSAP1 LILRB5

3.73e-0518614868694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRB1 FIGN CCDC13 SLC24A2 INAVA EPHA5

3.84e-05187148616e55d802fc4e71878305e61ad03806aabd59537
ToppCelldroplet-Pancreas-Exocrine-24m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXB9 HMCN1 ARHGAP31 CLEC14A ENG ITPRIPL1

3.84e-051871486a178b1fed80a0bf83aedb6262493ee17374734b5
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 KIAA1549 LMNB1 VCAN ASPM C1orf94

3.84e-051871486a2076599b33ae6750961b573bfebcb9036fa4ee8
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 KIAA1549 LMNB1 VCAN ASPM C1orf94

3.84e-05187148638ee33295a21db4aae5ba085df033db9693e41c6
ToppCelldroplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXB9 HMCN1 ARHGAP31 CLEC14A ENG ITPRIPL1

3.84e-051871486e60cbccf5842f25123fd34b9475759b7424b32e9
Diseaseresponse to darapladib, lipoprotein-associated phospholipase A(2) change measurement

PLA2G7 APOE

7.27e-0531462EFO_0008395, EFO_0008432
DiseaseFEV/FEC ratio

MGAM PCDHGA5 FPR1 JMJD1C TG HIVEP3 SMIM23 NPTN GTF2I HMCN1 ANAPC1 ARHGAP31 ACAN CNTN5 NAV1 KDM7A PTCD3

1.27e-04122814617EFO_0004713
Diseaseage related macular degeneration 1 (is_implicated_in)

APOE HMCN1

1.45e-0441462DOID:0110014 (is_implicated_in)
Diseaseanaphylaxis

NLRP3 KNG1

1.45e-0441462C0002792
Diseaseage-related macular degeneration, cataract, glaucoma

PCDHGA5 HERC2

1.45e-0441462EFO_0001365, MONDO_0005041, MONDO_0005129
DiseaseMacular Degeneration, Age-Related, 1

APOE HMCN1

1.45e-0441462C1864205
DiseaseLiddle syndrome (implicated_via_orthology)

NEDD4L NEDD4

1.45e-0441462DOID:0050477 (implicated_via_orthology)
DiseaseMACULAR DEGENERATION, AGE-RELATED, 1

APOE HMCN1

1.45e-0441462603075
DiseaseAge related macular degeneration 1

APOE HMCN1

1.45e-0441462cv:C1864205
Diseaseaspartate aminotransferase measurement

NEDD4L PROCR PDPK1 FSTL4 ARMC9 CPN1 APOE ARHGAP35 BIRC6 NLRP3 SLC17A5 NPTN LILRB5 ALPK2

1.66e-0490414614EFO_0004736
DiseaseSarcosine measurement

PCDHGB2 PCDHGA5 CNTN5

1.95e-04231463EFO_0021668
Diseaseerythrocyte band 7 integral membrane protein measurement

APOE BSN

2.41e-0451462EFO_0801584
Diseasemultiple myeloma

CACNA2D1 ARMC9 HERC2 DSEL PREX1

2.43e-041121465EFO_0001378
Diseaseaortic measurement

TNRC6B FIGN JMJD1C HIVEP3 HMCN1 NAV1 PREX1

2.64e-042511467EFO_0020865
Diseaseneuroimaging measurement

RELN ARHGEF12 TNRC6B ARMC9 APOE ARHGAP35 METTL4 JMJD1C TG JAG2 ZNF462 NCOR1 THBS1 VCAN CAMTA1

2.80e-04106914615EFO_0004346
Diseasemuscular atrophy (biomarker_via_orthology)

HSP90AB4P NEDD4 DMD

3.95e-04291463DOID:767 (biomarker_via_orthology)
Diseasepuberty onset measurement

BIRC6 JMJD1C GTF2I HERC2 CAMTA1

4.03e-041251465EFO_0005677
DiseaseTinnitus

PCNX3 E2F7 TNRC6B JAG2 PTPN13

4.83e-041301465HP_0000360
DiseasePolysyndactyly

NEDD4L JAG2

5.02e-0471462C0265553
Diseasecerebrovascular disease (is_implicated_in)

SELE APOE

6.68e-0481462DOID:6713 (is_implicated_in)
DiseaseSyndactyly

NEDD4L JAG2

6.68e-0481462C0039075
Diseaseascending aortic diameter

TNRC6B FIGN JMJD1C HIVEP3 HMCN1

6.76e-041401465EFO_0021787
Diseasemyeloid white cell count

SELE ARHGEF12 CHI3L2 CIT FCHO1 JMJD1C NLRP3 JAG2 HIVEP3 CNTN5 OSCP1 PRORP PREX1

8.01e-0493714613EFO_0007988
Diseasefetuin-B measurement

JMJD1C KNG1

1.07e-03101462EFO_0008128
DiseaseNeoplasm of uncertain or unknown behavior of breast

PDPK1 NCOR1 HERC2

1.10e-03411463C0496956
DiseaseBreast adenocarcinoma

PDPK1 NCOR1 HERC2

1.10e-03411463C0858252
Diseaseaortic stenosis, aortic valve calcification

PCDHGA5 ACAN NAV1

1.18e-03421463EFO_0000266, EFO_0005239
Diseasecortical thickness

RELN ARHGEF12 TNRC6B APOE ARHGAP35 JMJD1C TG JAG2 ZNF462 SMIM23 THBS1 VCAN NAV1 CAMTA1

1.29e-03111314614EFO_0004840
DiseasePR domain zinc finger protein 1 measurement

USP4 BSN

1.30e-03111462EFO_0801904
Diseasechemotherapy-induced alopecia, response to antimicrotubule agent

PCDHGA5 ZNF462

1.30e-03111462EFO_0005260, EFO_0005400
Diseasevisual epilepsy (is_implicated_in)

CDKL5 ASPM

1.30e-03111462DOID:11832 (is_implicated_in)
DiseaseMultiple Sclerosis

SELE APOE NLRP3

1.45e-03451463C0026769
DiseaseMultiple Sclerosis, Acute Fulminating

SELE APOE NLRP3

1.45e-03451463C0751324
Diseaseintracranial aneurysm (is_implicated_in)

VCAN ENG

1.55e-03121462DOID:10941 (is_implicated_in)
Diseaseabdominal aortic aneurysm (is_implicated_in)

PLA2G7 APOE

1.55e-03121462DOID:7693 (is_implicated_in)
Diseasecoronary artery disease (is_implicated_in)

SELE PLA2G7 APOE ARHGAP31

1.56e-031001464DOID:3393 (is_implicated_in)
DiseaseAdenoid Cystic Carcinoma

JMJD1C VCAN ASPM KDM6A

1.56e-031001464C0010606
Diseasediastolic blood pressure, systolic blood pressure

PROCR TNRC6B ARMC9 FIGN ZBTB44 LIG3 PPP5C ACAN NAV1 VWA3B

1.90e-0367014610EFO_0006335, EFO_0006336
Diseaseserum gamma-glutamyl transferase measurement

NEDD4L PCNX3 FPR1 CPN1 APOE ARHGAP35 CIT FCHO1 JMJD1C NPTN SLC24A2 ALPK2

2.02e-0391414612EFO_0004532
Diseasechenodeoxycholate measurement

FPR1 HMCN1

2.45e-03151462EFO_0010471
Diseasefactor VII measurement

PROCR NEDD4 CNTN5

2.58e-03551463EFO_0004619
DiseaseHypertensive disease

CACNA2D1 NEDD4L APOE NPTN KNG1

2.61e-031901465C0020538
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

PROCR NLRP3 KNG1

2.72e-03561463EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Diseasebody composition measurement

NOX5 TNRC6B APOE JAG2 ACAN

2.79e-031931465EFO_0005106
Diseaseneutrophil collagenase measurement

CPN1 APOE

2.79e-03161462EFO_0008248
Diseaseatherosclerosis (is_implicated_in)

PLA2G7 APOE

2.79e-03161462DOID:1936 (is_implicated_in)
Diseaseprimary autosomal recessive microcephaly (is_implicated_in)

LMNB1 ASPM

2.79e-03161462DOID:0070296 (is_implicated_in)
Diseasefibrinogen measurement, factor VII measurement

PROCR JMJD1C NLRP3

3.00e-03581463EFO_0004619, EFO_0004623
Diseasebody fat percentage

RELN APOE HIVEP3 TRIM66 LMNB1 ACAN CAMTA1 PRRC2B

3.06e-034881468EFO_0007800
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor, mood disorder

FSTL4 DSEL

3.15e-03171462EFO_0003761, EFO_0004247, EFO_0005658
DiseaseIschemic stroke, venous thromboembolism, stroke, Abnormal thrombosis, deep vein thrombosis, pulmonary embolism

PROCR KNG1

3.15e-03171462EFO_0000712, EFO_0003827, EFO_0003907, EFO_0004286, HP_0001977, HP_0002140
Diseaseangina pectoris

PCNX3 ARHGEF12 APOE FIGN

3.51e-031251464EFO_0003913
Diseasesphingosine 1-phosphate measurement

DMD KDM6A

3.53e-03181462EFO_0800185
Diseasenephrotic syndrome (is_marker_for)

PLA2G7 APOE

3.53e-03181462DOID:1184 (is_marker_for)
DiseaseAge-related macular degeneration

APOE HMCN1

3.53e-03181462cv:C0242383
DiseaseAdenocarcinoma of lung (disorder)

ARHGAP35 SFXN1 LMNB1 RPS6KA6 EPHA5

3.68e-032061465C0152013
Diseaseintraocular pressure measurement

RELN PCDHGA5 ARHGEF12 NEDD4 HIVEP3 ANAPC1 HERC2 DSEL

3.94e-035091468EFO_0004695
Diseasewhite matter hyperintensity measurement

APOE ARHGAP35 EPN2 VCAN RECQL5 MUTYH

4.01e-033021466EFO_0005665
Diseasevenous thromboembolism, fibrinogen measurement

PROCR JMJD1C NLRP3

4.51e-03671463EFO_0004286, EFO_0004623
Diseasealkaline phosphatase measurement

SELE NEDD4L PROCR ERGIC2 APOE JMJD1C NLRP3 HIVEP3 UBE2R2 IFI30 B4GALNT3 ALPK2

4.69e-03101514612EFO_0004533
Diseaseaggressive behaviour measurement, ADHD symptom measurement

BIRC6 CFAP77 KDM7A

4.70e-03681463EFO_0007826, EFO_0007860
Diseasemuscular dystrophy (implicated_via_orthology)

LMNB1 DMD

4.80e-03211462DOID:9884 (implicated_via_orthology)
Diseaseprothrombin time measurement

PROCR JMJD1C

4.80e-03211462EFO_0008390

Protein segments in the cluster

PeptideGeneStartEntry
QPLQEPESWARTQSG

PROCR

71

Q9UNN8
EEWLTTSPKTRPQNG

CAMTA1

91

Q9Y6Y1
QNWLVEVPTVSPNSR

ERVK-18

66

O42043
TEPEPELRQQTEWQS

APOE

26

P02649
SSGPDLTRWRKQQQP

CFAP77

6

Q6ZQR2
RPEEKWNPQTSSFLQ

BIRC6

4676

Q9NR09
TIEPAKLWSRQEVNP

VCAN

2091

P13611
PAGDSPRKTQWLNQV

B4GALNT3

551

Q6L9W6
EKQQTPNKRPWESLR

ADGRB1

1521

O14514
SEIWPPRQLTNSESK

ALPK2

1246

Q86TB3
AKNSISLSWQEPDRP

EPHA5

481

P54756
PTVFDLSPQQKEWQR

ERGIC2

111

Q96RQ1
SPQQVWEKFLSSETP

ACSF3

271

Q4G176
WSQDRQEPGKFTPEN

CHI3L2

36

Q15782
EWAQSKATVRPPDQL

DNAI1

41

Q9UI46
SVQGPWERAISPNKV

DMD

3056

P11532
PAQWRENSQLDTSPP

BOLA1

111

Q9Y3E2
KRVQGLPEASQPWTS

C1orf94

71

Q6P1W5
PLTTWRQKREQSPSQ

CAMSAP1

851

Q5T5Y3
SKIDWNNIRNSPPPF

CIT

361

O14578
TLQASKQNGTWPREV

ENG

81

P17813
QVPQSPEDWRKSEVS

ASPM

421

Q8IZT6
NPQSSSTQWEVAPEK

ATG2A

741

Q2TAZ0
FTPNWPVQNPDSRKS

ALPK1

821

Q96QP1
DLETDPPNWQQLVSR

ARHGEF12

761

Q9NZN5
KSPPSQAPSNLRWEQ

CNTN5

971

O94779
VKNNLNPSWEPFRLS

CPNE6

196

O95741
EWQPPLKNVSSSTDV

RAG1

521

P15918
KEERRVQQAPPNTDW

PCDHGA5

801

Q9Y5G8
LIEQAPPNTDWRFSQ

PCDHGA12

806

O60330
TRTQPGRPDWSKVFQ

NOX5

711

Q96PH1
RVKRPSPESQSNNLW

KIAA1549

1286

Q9HCM3
PNSKWVDSNVPQIIR

ANAPC1

1421

Q9H1A4
RPWASRQNKPSSVIQ

CDRT4

61

Q8N9R6
SPEKQERNLNWTPAE

PAXIP1

256

Q6ZW49
EPVTNVRLQPAATWN

FCHO1

796

O14526
GRKNESEPWQPSLNS

FIGN

101

Q5HY92
SQPIRQTAQDWPATS

PTCD3

561

Q96EY7
LQPSSTVPEWRAKDN

KDM7A

561

Q6ZMT4
TQWKRPTPQDNLTDA

NEDD4

636

P46934
SQWAPLSRQPKDNQD

NMS

51

Q5H8A3
EVDNWRIIPRNNPSS

MBTPS1

81

Q14703
LSPNPWQEKREIVSS

HERC2

3461

O95714
VQSVPKNSDPWAASQ

EPN2

401

O95208
NQTKPIWTRNPDDIT

HSP90AB4P

256

Q58FF6
SRLPREESANNQWAP

JAG2

1116

Q9Y219
QQSVSRPASWKLQTP

CFAP65

1581

Q6ZU64
NVQWSGDEPLQRPVT

ARMC9

641

Q7Z3E5
KTWPIFNRDTTPNGN

MGAM

281

O43451
TLKNSQPPWDQIQED

JMJD1C

426

Q15652
RTQLLQPADENWDPT

KDM6A

1001

O15550
TASPPTDLIWKNQNS

LMNB1

506

P20700
STPRLVWQESSQEAP

BSN

1541

Q9UPA5
DQELNKTKPIWTRNP

HSP90AA5P

111

Q58FG0
SQPVDQDWNSPLVTL

PCNX3

1566

Q9H6A9
NLPVEDIQKRPDQTW

MORC3

396

Q14149
LKQAPPNTDWRFSQA

PCDHGB2

806

Q9Y5G2
TPQDRKNSVWTQDGP

NOL6

951

Q9H6R4
WRQEKAPQTVELPAV

MEGF8

1606

Q7Z7M0
TEEAKNWAPGEPNNR

SELE

91

P16581
KNPQVWSNPSDLLEI

LILRB5

201

O75023
SWITHRDQLPNDQPK

RPS6KA6

681

Q9UK32
SRDKNPAAQQVSPEW

LIG3

981

P49916
PSQDNDRLDTLWIPN

PLA2G7

86

Q13093
SIPESEWTQQTQRPA

ACAN

2216

P16112
FRWIQESSSQKNVPP

RELN

1386

P78509
QAVNTWRIPFDPSLK

HMCN1

231

Q96RW7
NGIPNPSITWLKDDQ

HMCN1

1851

Q96RW7
PSITWLKDDQPVNTA

HMCN1

1856

Q96RW7
DKERPDQTNPSANWL

HOXB9

166

P17482
SQAPDQEQLTSVDWP

ITPRIPL1

381

Q6GPH6
KTAENPQNTRAWLNP

HSPBAP1

296

Q96EW2
PQNTRAWLNPTEVEE

HSPBAP1

301

Q96EW2
PDNWKSQVEPETRAV

CPN1

186

P15169
KFVDRQQAEPWTPTA

E2F7

71

Q96AV8
LQNGPIRKNWNSSVP

DUSP11

246

O75319
PWVTVNGKPLEDQTQ

IFI30

206

P13284
SPWVDNSRTPNKIDL

CACNA2D1

221

P54289
PQREKNATQPCQWVS

FSTL4

491

Q6MZW2
PRFSDSPEQKGWQAQ

CCDC13

531

Q8IYE1
QNWLVEVPTVSPNSR

ERVK-5

66

Q9HDB8
LQWQKRNAAPPPSNT

DDX24

256

Q9GZR7
QVKVEEPSRPSASWQ

FOXM1

216

Q08050
GRPWKSVSEINPTTQ

KNG1

616

P01042
PSKRPWARQENQEAE

EGLN2

131

Q96KS0
VTKQPTNRVPWRSSN

DPEP3

451

Q9H4B8
PQSRAWEDPVEKQLQ

EPS8L1

431

Q8TE68
VTQPRTNTPVKEDWN

GTF2I

551

P78347
WRPEKISDLQTQSQP

CDKL5

821

O76039
RNQLSSQKSVPWVPI

SLC17A5

271

Q9NRA2
PTNTNVWKQNLPRDE

DSEL

1176

Q8IZU8
KDRWALQTPTELQGN

IFT140

366

Q96RY7
RAPVQNSPWKETSLD

INAVA

316

Q3KP66
QEELNKTKPIWTRNP

HSP90AA2P

286

Q14568
IDPPWQNKSVKRSNR

METTL4

286

Q8N3J2
SPLTWQPLENQKDQI

LRCH2

521

Q5VUJ6
PTRQENWTPLKNDLE

PTPN13

1761

Q12923
GDVFWKNLNQRPTPT

INCA1

41

Q0VD86
KNLNQRPTPTWLEEQ

INCA1

46

Q0VD86
EPKWGSDNARVSNPT

NLRP3

91

Q96P20
VWDPNSPLTDRQIDQ

MTA3

181

Q9BTC8
RDTLPWPSAQQDQSK

NAV1

1796

Q8NEY1
SVKDPSQSQSRLPQW

TNRC6C

1286

Q9HCJ0
PPNINIKEPRWDQST

SFXN1

6

Q9H9B4
SSWKTPPQENRDKNL

TCP10L

176

Q8TDR4
DQPLSLAWPSETRKQ

SLC24A2

456

Q9UI40
EQTQPATPSLWKNKE

NBN

491

O60934
NNSLPITEWIRPNSK

SLC22A10

216

Q63ZE4
EEVWLPNNSSRNSSP

SLC26A8

681

Q96RN1
TWENLHQQTPPKLTA

PDPK1

346

O15530
WSDPQPQNGRSISKR

PPP5C

386

P53041
SPWTNDPKERINVAV

FPR1

181

P21462
TSKSPNREWEVLQPA

NCOR1

996

O75376
ISIQEDPWNLPNSIK

PREX1

1276

Q8TCU6
DPWNLPNSIKTLVDN

PREX1

1281

Q8TCU6
TNEPSEEPIKTIRNW

SMIM23

81

A6NLE4
FPSVTWEPSEQLQRK

MUTYH

401

Q9UIF7
QPPEDIKALSWNRQA

SEC31B

166

Q9NQW1
KNLASWTQESIAPNP

OSCP1

276

Q8WVF1
TIQLPTQPLNSEEWD

PRORP

111

O15091
GQRKSVSSSPWLPQD

ARHGAP35

1066

Q9NRY4
SPSNIKAQFRQSWPT

SNRK

351

Q9NRH2
QDNSVTSIPEIPRWG

CLEC14A

336

Q86T13
WKGKRPRSQQENPES

RECQL5

851

O94762
PVSAQKRWNSLPSEN

TOMM34

151

Q15785
WGPTSQDTIRNQVRK

UBXN6

71

Q9BZV1
DPKGTSQNDPNWVVR

THBS1

966

P07996
EPQNEDGTWPRQTLQ

USP4

216

Q13107
VLNRSKSWSLQQPEP

TRIM68

266

Q6AZZ1
SGELPSERWNPTQNV

CDC34

106

P49427
WRNSTEETAPEQPQS

ZSCAN20

841

P17040
SLRSQWKQEVQPEEP

ZSCAN32

146

Q9NX65
WATQKNEIQASESPP

SPEM2

61

Q0P670
DPKRNDLRQNPSITW

NPTN

121

Q9Y639
SSILWNTPNSQPEKG

ZBTB44

126

Q8NCP5
WPQRSQTLAQLPAEK

HIVEP3

886

Q5T1R4
PVQAPANDSWRKAVT

PRRC2B

1636

Q5JSZ5
VSTPLEVWTRDPANQ

ARHGAP31

711

Q2M1Z3
APSPQDLSAQWKQLE

RFPL2

66

O75678
APSLRDPSQPQQWVS

TMEM201

101

Q5SNT2
LSNRVWSISQEPDPV

TRIM14

161

Q14142
WSISQEPDPVQRLQA

TRIM14

166

Q14142
SPPVRKSNWRQQHED

ZC2HC1B

71

Q5TFG8
PSWNQEVKLEIPSFN

ZGRF1

396

Q86YA3
WVRDTSEPQKEPNFR

ZNF462

761

Q96JM2
WTSKPEPSTREQFLQ

TRIM16

356

O95361
SGELPSERWNPTQNV

UBE2R2

106

Q712K3
RVSQEPVKWQENATP

VWA3B

181

Q502W6
WLETQPPVEQESTSQ

TRIM66

386

O15016
LSSWKQARSQENPSP

TG

1086

P01266
KRSPAWNETGRQPNS

TNRC6B

801

Q9UPQ9
LNASPKTSATQPWNR

TTI1

456

O43156
QPGNEQWKSSDTLPV

ZRANB3

716

Q5FWF4
ENWQRVNTELPVKSP

MYOM1

681

P52179
SFNRTPKGWISENIP

MYOZ2

231

Q9NPC6
SKITQWEDPRLQNPA

NEDD4L

571

Q96PU5