Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	CDX1 TCF12 ZBTB7C ZNF316 GATA6 IRF2 IRF7 NR1D1 GFI1 BPTF ZNF394 SOX21 NFATC4 UBP1 ZNF764 PITX3 SKOR1 ZFHX2 PAX5 NEUROG2 PRDM15 FOXI1	1.67e-05	1244	130	22	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	CDX1 TCF12 ZBTB7C ZNF316 GATA6 IRF2 IRF7 NR1D1 GFI1 BPTF ZNF394 SOX21 NFATC4 UBP1 ZNF764 PITX3 SKOR1 ZFHX2 PAX5 NEUROG2 PRDM15 FOXI1	2.32e-05	1271	130	22	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	CDX1 TCF12 ERFL ZBTB7C ZNF316 GATA6 IRF2 IRF7 NR1D1 GFI1 GTF2I ZNF394 SOX21 NFATC4 UBP1 ZNF764 PITX3 SKOR1 ZFHX2 PAX5 NEUROG2 PRDM15 FOXI1	3.84e-05	1412	130	23	GO:0000981
GeneOntologyMolecularFunction	monoamine oxidase activity	MAOA MAOB	1.26e-04	3	130	2	GO:0097621
GeneOntologyMolecularFunction	sulfuric ester hydrolase activity	ARSJ SGSH ARSI	1.72e-04	17	130	3	GO:0008484
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	CDX1 TCF12 ZBTB7C ZNF316 GATA6 IRF2 IRF7 NR1D1 GFI1 BPTF ZNF394 SOX21 NFATC4 UBP1 ZNF764 PITX3 SKOR1 ZFHX2 PAX5 NEUROG2 PRDM15 FOXI1	1.78e-04	1459	130	22	GO:0000977
GeneOntologyMolecularFunction	aliphatic amine oxidase activity	MAOA MAOB	2.50e-04	4	130	2	GO:0052595
GeneOntologyCellularComponent	USH2 complex	WHRN USH2A	2.32e-04	4	131	2	GO:1990696
GeneOntologyCellularComponent	stereocilia ankle link	WHRN USH2A	5.75e-04	6	131	2	GO:0002141
GeneOntologyCellularComponent	stereocilia ankle link complex	WHRN USH2A	5.75e-04	6	131	2	GO:0002142
GeneOntologyCellularComponent	periciliary membrane compartment	WHRN USH2A	5.75e-04	6	131	2	GO:1990075
Domain	Flavin_amine_oxidase	MAOA MAOB	1.31e-04	3	124	2	IPR001613
Domain	Vg_fam	VGLL3 VGLL2	1.31e-04	3	124	2	IPR011520
Domain	Vg_Tdu	VGLL3 VGLL2	1.31e-04	3	124	2	PF07545
Domain	Sulfatase_CS	ARSJ SGSH ARSI	1.50e-04	16	124	3	IPR024607
Domain	SULFATASE_1	ARSJ SGSH ARSI	1.81e-04	17	124	3	PS00523
Domain	SULFATASE_2	ARSJ SGSH ARSI	1.81e-04	17	124	3	PS00149
Domain	Sulfatase	ARSJ SGSH ARSI	2.17e-04	18	124	3	PF00884
Domain	Sulfatase_N	ARSJ SGSH ARSI	2.17e-04	18	124	3	IPR000917
Domain	TDU	VGLL3 VGLL2	2.60e-04	4	124	2	SM00711
Domain	TDU_repeat	VGLL3 VGLL2	2.60e-04	4	124	2	IPR006627
Domain	MAGE_N	MAGEB1 MAGEB4 MAGEB17	3.00e-04	20	124	3	SM01392
Domain	MAGE_N	MAGEB1 MAGEB4 MAGEB17	4.01e-04	22	124	3	PF12440
Domain	MAGE_N	MAGEB1 MAGEB4 MAGEB17	4.01e-04	22	124	3	IPR021072
Domain	Alkaline_phosphatase_core	ARSJ SGSH ARSI	1.12e-03	31	124	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSJ SGSH ARSI	1.12e-03	31	124	3	IPR017849
Domain	-	ARSJ SGSH ARSI	1.12e-03	31	124	3	3.40.720.10
Domain	MAGE	MAGEB1 MAGEB4 MAGEB17	1.47e-03	34	124	3	SM01373
Domain	IRF	IRF2 IRF7	1.53e-03	9	124	2	SM00348
Domain	Interferon_reg_fact_DNA-bd_dom	IRF2 IRF7	1.53e-03	9	124	2	IPR001346
Domain	IRF	IRF2 IRF7	1.53e-03	9	124	2	PF00605
Domain	IRF_1	IRF2 IRF7	1.53e-03	9	124	2	PS00601
Domain	Interferon_reg_fac_CS	IRF2 IRF7	1.53e-03	9	124	2	IPR019817
Domain	IRF_2	IRF2 IRF7	1.53e-03	9	124	2	PS51507
Domain	MAGE	MAGEB1 MAGEB4 MAGEB17	1.74e-03	36	124	3	PS50838
Domain	MAGE	MAGEB1 MAGEB4 MAGEB17	1.74e-03	36	124	3	PF01454
Domain	MHD_dom	MAGEB1 MAGEB4 MAGEB17	1.74e-03	36	124	3	IPR002190
Domain	Amino_oxidase	MAOA MAOB	1.90e-03	10	124	2	IPR002937
Domain	Amino_oxidase	MAOA MAOB	1.90e-03	10	124	2	PF01593
Domain	CUB	SEZ6L2 LRP3 PCOLCE	4.21e-03	49	124	3	PF00431
Domain	CUB	SEZ6L2 LRP3 PCOLCE	4.46e-03	50	124	3	SM00042
Domain	-	SEZ6L2 LRP3 PCOLCE	4.98e-03	52	124	3	2.60.120.290
Domain	CUB	SEZ6L2 LRP3 PCOLCE	5.25e-03	53	124	3	PS01180
Domain	CUB_dom	SEZ6L2 LRP3 PCOLCE	6.44e-03	57	124	3	IPR000859
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	NEU4 ARSJ GLB1L SMPD4 ARSI	2.16e-06	34	89	5	MM17076
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	NEU4 ARSJ GLB1L SMPD4 ARSI	4.35e-06	39	89	5	M48042
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	NEU4 ARSJ GLB1L SMPD4 ARSI	2.02e-05	53	89	5	MM14647
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	NEU4 ARSJ GLB1L SMPD4 ARSI	3.15e-05	58	89	5	M576
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	NEU4 ARSJ GLB1L SMPD4 ARSI	2.86e-04	92	89	5	MM15086
Pathway	KEGG_MEDICUS_REFERENCE_SEROTONIN_METABOLISM	MAOA MAOB	3.89e-04	5	89	2	M47902
Pathway	REACTOME_HS_GAG_DEGRADATION	SGSH GLB1L IDUA	3.93e-04	23	89	3	MM14804
Pathway	REACTOME_HS_GAG_DEGRADATION	SGSH GLB1L IDUA	4.47e-04	24	89	3	M636
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	CDX1 TCF12 GATA6 IRF2 IRF7 NR1D1 GFI1 NFATC4 UBP1 PITX3 SKOR1 NEUROG2 FOXI1	1.72e-07	544	132	13	28473536
Pubmed	A census of human transcription factors: function, expression and evolution.	CDX1 TCF12 GATA6 AKNA IRF2 IRF7 NR1D1 SOX21 NFATC4 UBP1 PITX3 SKOR1 ZFHX2 PAX5 NEUROG2 FOXI1	3.83e-07	908	132	16	19274049
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	VHL CDX1 TCF12 GATA6 POU2AF1 IRF7 EYA3 GFI1 GTF2I NFATC4 UBP1 ZNF764 PITX3 NEUROG2 HR	1.31e-06	877	132	15	20211142
Pubmed	The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.	MAOB PAX5 NEUROG2	6.29e-06	10	132	3	15872002
Pubmed	Tcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons.	TCF12 PITX3 NEUROG2	8.62e-06	11	132	3	29163030
Pubmed	Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans.	MAOA MAOB	1.43e-05	2	132	2	19657584
Pubmed	Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence.	MAOA MAOB	1.43e-05	2	132	2	21971001
Pubmed	Structural properties of human monoamine oxidases A and B.	MAOA MAOB	1.43e-05	2	132	2	21971000
Pubmed	Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.	MAOA MAOB	1.43e-05	2	132	2	23858446
Pubmed	Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography.	MAOA MAOB	1.43e-05	2	132	2	21075085
Pubmed	Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.	MAOA MAOB	1.43e-05	2	132	2	25398695
Pubmed	Transcriptional regulation and multiple functions of MAO genes.	MAOA MAOB	1.43e-05	2	132	2	21359973
Pubmed	Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.	LEPR FITM2	1.43e-05	2	132	2	35254894
Pubmed	Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling.	MAOA MAOB	1.43e-05	2	132	2	11861643
Pubmed	human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.	MAOA MAOB	1.43e-05	2	132	2	32598328
Pubmed	Monoamine oxidase A and A/B knockout mice display autistic-like features.	MAOA MAOB	1.43e-05	2	132	2	22850464
Pubmed	Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder.	MAOA MAOB	1.43e-05	2	132	2	17427196
Pubmed	Selective Interactions of O-Methylated Flavonoid Natural Products with Human Monoamine Oxidase-A and -B.	MAOA MAOB	1.43e-05	2	132	2	33212830
Pubmed	Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms.	MAOA MAOB	1.43e-05	2	132	2	18092818
Pubmed	Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia.	MAOA MAOB	1.43e-05	2	132	2	20589923
Pubmed	Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis.	MAOA MAOB	1.43e-05	2	132	2	21697081
Pubmed	Increased baroreceptor response in mice deficient in monoamine oxidase A and B.	MAOA MAOB	1.43e-05	2	132	2	11834493
Pubmed	cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.	MAOA MAOB	1.43e-05	2	132	2	3387449
Pubmed	Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease.	MAOA MAOB	1.43e-05	2	132	2	17044053
Pubmed	Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines.	MAOA MAOB	1.43e-05	2	132	2	8316221
Pubmed	Association between monoamine oxidase gene polymorphisms and smoking behavior: A meta-analysis.	MAOA MAOB	1.43e-05	2	132	2	26051160
Pubmed	Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B.	MAOA MAOB	1.43e-05	2	132	2	16129825
Pubmed	A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior.	MAOA MAOB	1.43e-05	2	132	2	15272015
Pubmed	Promoter organization and activity of human monoamine oxidase (MAO) A and B genes.	MAOA MAOB	1.43e-05	2	132	2	1432104
Pubmed	Monoamine oxidases A and B gene polymorphisms in migraine patients.	MAOA MAOB	1.43e-05	2	132	2	15694196
Pubmed	Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities.	MAOA MAOB	1.43e-05	2	132	2	12777388
Pubmed	The influence of monoamine oxidase variants on the risk of betel quid-associated oral and pharyngeal cancer.	MAOA MAOB	1.43e-05	2	132	2	25389533
Pubmed	Substrates but not inhibitors alter the redox potentials of monoamine oxidases.	MAOA MAOB	1.43e-05	2	132	2	11761322
Pubmed	Evidence for a genetic association between monoamine oxidase A and restless legs syndrome.	MAOA MAOB	1.43e-05	2	132	2	12136060
Pubmed	The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain.	MAOA MAOB	1.43e-05	2	132	2	20493079
Pubmed	Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions.	LEPR PCOLCE	1.43e-05	2	132	2	34369899
Pubmed	Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.	MAOA MAOB	1.43e-05	2	132	2	29050386
Pubmed	Sex-dependent monoamine oxidase isoforms expression patterns during human brain ageing.	MAOA MAOB	1.43e-05	2	132	2	34097937
Pubmed	Differential age-related changes of MAO-A and MAO-B in mouse brain and peripheral organs.	MAOA MAOB	1.43e-05	2	132	2	7969716
Pubmed	The FAD binding sites of human monoamine oxidases A and B.	MAOA MAOB	1.43e-05	2	132	2	14697881
Pubmed	Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody.	MAOA MAOB	1.43e-05	2	132	2	7063850
Pubmed	Which genotype of MAO gene that the patients have are likely to be most susceptible to the symptoms of fibromyalgia?	MAOA MAOB	1.43e-05	2	132	2	17885758
Pubmed	BUD13 Promotes a Type I Interferon Response by Countering Intron Retention in Irf7.	BUD13 IRF7	1.43e-05	2	132	2	30639243
Pubmed	MAO-A and -B gene knock-out mice exhibit distinctly different behavior.	MAOA MAOB	1.43e-05	2	132	2	10591056
Pubmed	Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese.	MAOA MAOB	1.43e-05	2	132	2	21978760
Pubmed	Type B and A monoamine oxidase and their inhibitors regulate the gene expression of Bcl-2 and neurotrophic factors in human glioblastoma U118MG cells: different signal pathways for neuroprotection by selegiline and rasagiline.	MAOA MAOB	1.43e-05	2	132	2	28577058
Pubmed	Assignment of genes for human monoamine oxidases A and B to the X chromosome.	MAOA MAOB	1.43e-05	2	132	2	3540317
Pubmed	Two cases of Marie Unna hereditary hypotrichosis: clinical features and mutation analysis of the U2HR and EPS8L3 genes.	EPS8L3 HR	1.43e-05	2	132	2	24236410
Pubmed	Human monoamine oxidase A and B genes exhibit identical exon-intron organization.	MAOA MAOB	1.43e-05	2	132	2	2023912
Pubmed	The genotypes and methylation of MAO genes as factors behind smoking behavior.	MAOA MAOB	1.43e-05	2	132	2	28858992
Pubmed	Deletion of MAOA and MAOB in a male patient causes severe developmental delay, intermittent hypotonia and stereotypical hand movements.	MAOA MAOB	1.43e-05	2	132	2	20485326
Pubmed	Association analysis of the functional MAOA gene promoter and MAOB gene intron 13 polymorphisms in tension type headache patients.	MAOA MAOB	1.43e-05	2	132	2	25618115
Pubmed	Monoamine oxidase polymorphisms and smoking behaviour in Japanese.	MAOA MAOB	1.43e-05	2	132	2	12563176
Pubmed	Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B.	MAOA MAOB	1.43e-05	2	132	2	30809547
Pubmed	Influence of the environment on the oxidative deamination of p-substituted benzylamines in monoamine oxidase.	MAOA MAOB	1.43e-05	2	132	2	25671411
Pubmed	Monoamine oxidase and agitation in psychiatric patients.	MAOA MAOB	1.43e-05	2	132	2	26851573
Pubmed	Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands.	MAOA MAOB	1.43e-05	2	132	2	28982350
Pubmed	Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups.	MAOA MAOB	1.43e-05	2	132	2	14962671
Pubmed	Monoamine Oxidase Deficiency Causes Prostate Atrophy and Reduces Prostate Progenitor Cell Activity.	MAOA MAOB	1.43e-05	2	132	2	29637670
Pubmed	Monoamine oxidase: from genes to behavior.	MAOA MAOB	1.43e-05	2	132	2	10202537
Pubmed	Expression patterns of sulfatase genes in the developing mouse embryo.	ARSJ SGSH ARSI	1.49e-05	13	132	3	20503373
Pubmed	Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis.	C6orf136 RBPMS2 ANKRD17	1.49e-05	13	132	3	17431699
Pubmed	Mutations in mice that influence natural killer (NK) cell activity.	LEPR HPS6 HR	1.89e-05	14	132	3	6971254
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	DSG1 SGSH IDUA PIGT PRCP TMEM131	4.02e-05	164	132	6	32409323
Pubmed	An overview of the MAGE gene family with the identification of all human members of the family.	MAGEB1 MAGEB4 MAGEB17	4.18e-05	18	132	3	11454705
Pubmed	Context-dependent regulation of hematopoietic lineage choice by HEBAlt.	TCF12 PAX5	4.28e-05	3	132	2	20826759
Pubmed	Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence.	MAOA MAOB	4.28e-05	3	132	2	25857233
Pubmed	Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.	MAOA MAOB	4.28e-05	3	132	2	16829576
Pubmed	Associations of MAOA-VNTR or 5HTT-LPR alleles with attention-deficit hyperactivity disorder symptoms are moderated by platelet monoamine oxidase B activity.	MAOA MAOB	4.28e-05	3	132	2	21610556
Pubmed	Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos.	MAOA MAOB	4.28e-05	3	132	2	24497636
Pubmed	Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB.	SGSH IDUA	4.28e-05	3	132	2	22558223
Pubmed	Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.	GFI1 LEPR	4.28e-05	3	132	2	29282250
Pubmed	Modification of the association between early adversity and obsessive-compulsive disorder by polymorphisms in the MAOA, MAOB and COMT genes.	MAOA MAOB	4.28e-05	3	132	2	27821364
Pubmed	Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice.	MAOA MAOB	4.28e-05	3	132	2	8041507
Pubmed	Characterization of the ternary Usher syndrome SANS/ush2a/whirlin protein complex.	WHRN USH2A	4.28e-05	3	132	2	28137943
Pubmed	Molecular cloning and initial characterization of three novel human sulfatases.	ARSJ ARSI	4.28e-05	3	132	2	16500042
Pubmed	ADHD and Disruptive Behavior scores - associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents.	MAOA MAOB	4.28e-05	3	132	2	18430257
Pubmed	Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease.	MAOA MAOB	4.28e-05	3	132	2	12428723
Pubmed	Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia.	MAOA MAOB	4.28e-05	3	132	2	15261699
Pubmed	Non-USH2A mutations in USH2 patients.	WHRN USH2A	4.28e-05	3	132	2	22147658
Pubmed	Hotspot DAXX, PTCH2 and CYFIP2 mutations in pancreatic neuroendocrine neoplasms.	CYFIP2 PTCH2	4.28e-05	3	132	2	30021865
Pubmed	Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia.	MAOA MAOB	4.28e-05	3	132	2	15211623
Pubmed	Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.	DICER1 NEUROG2	4.28e-05	3	132	2	22706270
Pubmed	Evaluation of heparin cofactor II-thrombin complex as a biomarker on blood spots from mucopolysaccharidosis I, IIIA and IIIB mice.	SGSH IDUA	4.28e-05	3	132	2	19926322
Pubmed	Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.	LEPR HCAR3	4.28e-05	3	132	2	27570060
Pubmed	Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells.	WHRN USH2A	4.28e-05	3	132	2	16301217
Pubmed	Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse.	MAOA MAOB	4.28e-05	3	132	2	11793338
Pubmed	Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase.	GFI1 N4BP2L2	4.28e-05	3	132	2	19506020
Pubmed	The mouse cortico-striatal projectome.	MAOA MAOB	4.28e-05	3	132	2	27322419
Pubmed	The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet.	NR1D1 LEPR	4.28e-05	3	132	2	22166979
Pubmed	The effects of DBH, MAOA, and MAOB on attentional biases for facial expressions.	MAOA MAOB	4.28e-05	3	132	2	23054588
Pubmed	The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1.	WHRN USH2A	4.28e-05	3	132	2	16434480
Pubmed	Tagging genes with cassette-exchange sites.	FLNB EYA3 BPTF UBP1 HELZ TMEM131 REXO1L1P ZMYM4	4.46e-05	335	132	8	15741177
Pubmed	Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.	CDX1 GATA6 PTCH2 LTBR	5.82e-05	55	132	4	10926756
Pubmed	FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region.	SOX21 PITX3 PAX5 NEUROG2	7.18e-05	58	132	4	16782087
Pubmed	Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.	POU2AF1 GTF2I	8.54e-05	4	132	2	21549311
Pubmed	Obesity is associated with genetic variants that alter dopamine availability.	MAOA MAOB	8.54e-05	4	132	2	16674552
Pubmed	Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss.	WHRN USH2A	8.54e-05	4	132	2	20502675
Pubmed	Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.	MAGEB1 MAGEB4	8.54e-05	4	132	2	9441743
Pubmed	Usher Syndrome Type II	WHRN USH2A	8.54e-05	4	132	2	20301515
Interaction	KRTAP19-7 interactions	NEU4 VGLL3 POU2AF1 RBPMS2 HELZ DTX2 FOXI1	9.33e-06	117	127	7	int:KRTAP19-7
GeneFamily	Sulfatases	ARSJ SGSH ARSI	6.73e-05	18	81	3	410
GeneFamily	Fibronectin type III domain containing\|USH2 complex	WHRN USH2A	1.18e-04	4	81	2	1244
GeneFamily	Vestigial like family	VGLL3 VGLL2	1.18e-04	4	81	2	367
GeneFamily	MAGE family	MAGEB1 MAGEB4 MAGEB17	7.59e-04	40	81	3	1136
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Nnat_(iSPN)\|Striatum / BrainAtlas - Mouse McCarroll V32	TPO BCL2L14 TMEM61 FER1L4 SKOR1	5.89e-07	54	133	5	d21611ae38d34d62f855fa3797eb37a5d287a4a5
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2.Adora2a-Nnat_(iSPN)-\|Striatum / BrainAtlas - Mouse McCarroll V32	TPO BCL2L14 TMEM61 FER1L4 SKOR1	5.89e-07	54	133	5	20309afadc500f1485e86c62d8d38168c9253539
ToppCell	facs-GAT-Fat-3m-Lymphocytic-B_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VGLL2 INPP5D POU2AF1 SHISA7 CYFIP2 PAX5 TEX44	1.10e-06	178	133	7	5b6f7e8a930c239db1f31edfb61b2b9228d28663
Drug	I 1100	MAOA MAOB	3.29e-05	2	131	2	CID000013067
Drug	trimethyl citrate	MAOA MAOB	3.29e-05	2	131	2	CID000074112
Drug	Pargyline	MAOA MAOB	3.29e-05	2	131	2	DB01626
Drug	tribulin	MAOA MAOB	3.29e-05	2	131	2	ctd:C039776
Drug	Isocarboxazid	MAOA MAOB	3.29e-05	2	131	2	DB01247
Drug	NSC310407	MAOA MAOB	3.29e-05	2	131	2	CID000171344
Drug	C05636	MAOA MAOB	3.29e-05	2	131	2	CID000440736
Drug	4,8-quinolinediol	MAOA MAOB	3.29e-05	2	131	2	CID000440737
Drug	Tranylcypromine	MAOA MAOB	3.29e-05	2	131	2	DB00752
Drug	ethyl 4-hydroxyphenylacetate	MAOA MAOB	3.29e-05	2	131	2	CID000028310
Drug	AC1L2OJZ	MAOA MAOB	3.29e-05	2	131	2	CID000125421
Drug	5HAA	MAOA MAOB	3.29e-05	2	131	2	CID000128291
Drug	methyl indole-3-propionate	MAOA MAOB	3.29e-05	2	131	2	CID000021711
Drug	3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one	MAOA MAOB	3.29e-05	2	131	2	ctd:C492672
Drug	2-chloroquinoxaline	MAOA MAOB	3.29e-05	2	131	2	CID000238938
Drug	Selegiline	MAOA MAOB	3.29e-05	2	131	2	DB01037
Drug	1 mm PP	MAOA MAOB	3.29e-05	2	131	2	CID000132866
Disease	Marie Unna congenital hypotrichosis	EPS8L3 HR	1.70e-05	2	122	2	C2931059
Disease	Pheochromocytoma, Extra-Adrenal	VHL MAOA MAOB	3.71e-05	16	122	3	C1257877
Disease	RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE	ATP6V0A4 FOXI1	5.07e-05	3	122	2	C1864498
Disease	Pheochromocytoma	VHL MAOA MAOB	6.37e-05	19	122	3	C0031511
Disease	Granulosa Cell Cancer	DICER1 LEPR	1.68e-04	5	122	2	C1567257
Disease	Usher Syndrome, Type II	WHRN USH2A	1.68e-04	5	122	2	C1568249
Disease	Bipolar Disorder	WHRN TPO MAOA MAOB GRIA3 NR1D1 ME2 HCAR3	8.49e-04	477	122	8	C0005586
Disease	coagulation factor XA measurement	WHRN AKNA	9.10e-04	11	122	2	EFO_0020266
Disease	Huntington Disease, Late Onset	MAOA MAOB	1.09e-03	12	122	2	C0393574
Disease	Akinetic-Rigid Variant of Huntington Disease	MAOA MAOB	1.09e-03	12	122	2	C0751207
Disease	Juvenile Huntington Disease	MAOA MAOB	1.09e-03	12	122	2	C0751208
Disease	Fulminant Hepatic Failure with Cerebral Edema	MAOA MAOB	1.28e-03	13	122	2	C0751197
Disease	Hepatic Stupor	MAOA MAOB	1.28e-03	13	122	2	C0751198
Disease	Hepatic Encephalopathy	MAOA MAOB	1.28e-03	13	122	2	C0019151
Disease	Hepatic Coma	MAOA MAOB	1.28e-03	13	122	2	C0019147
Disease	lipid metabolism disorder (implicated_via_orthology)	LPIN3 FITM2	1.72e-03	15	122	2	DOID:3146 (implicated_via_orthology)
Disease	autism spectrum disorder (is_implicated_in)	MAOA MBD6	1.96e-03	16	122	2	DOID:0060041 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	TCF12 LEPR LPIN3 DCHS1 ZFHX2	2.04e-03	215	122	5	DOID:9970 (implicated_via_orthology)
Disease	Huntington Disease	MAOA MAOB	2.21e-03	17	122	2	C0020179
Disease	aspartate aminotransferase to alanine aminotransferase ratio	PXMP4 WHRN AKNA CYFIP2 CLCN6	3.22e-03	239	122	5	EFO_0010934
Disease	multiple sclerosis	BCL2L14 DSG1 POU2AF1 BUD13 NR1D1 GFI1 LPIN3 LTBR	3.34e-03	594	122	8	MONDO_0005301
Disease	eosinophil percentage of leukocytes	NEU4 INPP5D POU2AF1 BUD13 ME2 LEPR BPTF TMEM131 LTBR	3.89e-03	746	122	9	EFO_0007991

Protein segments in the cluster

Peptide	Gene	Start	Entry
FAPPALPALWTPGFA	ERFL	11	A0A1W2PQ73
EYPWNFNPYLTGPFP	ERFL	226	A0A1W2PQ73
YSGPAPPPNRFNIWP	BUD13	566	Q9BRD0
TPSSPGAQRPTPYEW	CDX1	121	P47902
PACVPWSPYLFQPND	CFI	451	P05156
CPYPGAWIPFQVPGT	C6orf136	116	Q5SQH8
SQPPPASGYWVYSPI	CNTRL	1191	Q7Z7A1
PPTYFLDGETLSWGP	CCDC187	911	A0A096LP49
NPYPWPMFSSYPLPN	TBC1D32	896	Q96NH3
PGYGDWIPPQTLATF	ARSI	431	Q5FYB1
PLFFTFPPPGDTWEL	ABCA3	66	Q99758
FPPPGDTWELAYIPS	ABCA3	71	Q99758
VYSWPPPQATQAGGF	BCL2L14	161	Q9BZR8
TFPPAQSTWGPFPVR	ANKRD17	1916	O75179
VSIFDPPVNWLPPGY	DICER1	1371	Q9UPY3
ALDIWPYPSPRPTFG	BPTF	1876	Q12830
ALIPASPEAWAPYPL	RBPMS2	146	Q6ZRY4
TTPNWPESDYPPGIS	PCOLCE	171	Q15113
ATQTYGLPPFGALWP	EYA3	111	Q99504
GKGPPSASWFPSYPN	INTS6L	646	Q5JSJ4
SNPVPYNSSWPPFQD	IRF2	296	P14316
DSWRFPNPGLLGSPY	PAX5	356	Q02548
PPLYPWSQSLALPLA	KIAA0895L	36	Q68EN5
GWAAPGPEPTYPNST	LRRC8A	71	Q8IWT6
YPFRGAFPPVWNPIA	MAOA	106	P21397
SYPFRGPFPPVWNPI	MAOB	96	P27338
GPFPPVWNPITYLDH	MAOB	101	P27338
GPVLWYVLSPSGPQD	DCHS1	2306	Q96JQ0
QPKDIYPYSDGEWPP	LPIN3	196	Q9BQK8
PPPAISLNAPSYNWG	MBD6	216	Q96DN6
PNSDPPRYQFLWGPR	MAGEB1	261	P43366
PNSDPPRYQFLWGPR	MAGEB4	261	O15481
VPSSDPPRYEFLWGP	MAGEB17	261	A8MXT2
FWALPPSAPSERYPG	KIAA1671	1296	Q9BY89
ASPAGSDMDYWQPPP	NEUROG2	241	Q9H2A3
FEDFWRPPSPSASPA	GFI1	86	Q99684
AWGAAPPSLGSQPLY	DTX2	266	Q86UW9
LLTGNPGYSDWVPPQ	ARSJ	456	Q5FYB0
PGYSDWVPPQSFSNL	ARSJ	461	Q5FYB0
NPTFGPAWVPLYGSP	FER1L4	301	A9Z1Z3
WYNDTYPLSPPQRTP	CANT1	86	Q8WVQ1
DFWGLPSCPPQQIYP	C9orf131	821	Q5VYM1
PFWVPTCLPPYLVSG	HR	156	O43593
PPDPPNEFGIFNSLW	GRIA3	596	P42263
PPGFRPWVTEEAYVP	FLNB	1721	O75369
PVVFLPAYENPPAWI	PDZD11	11	Q5EBL8
WNPGFLYNGFPLPPV	TPO	191	P07202
PLPYQPTFSDDWQLP	EPS8L3	381	Q8TE67
DWQLPEPSSQAPLGY	EPS8L3	391	Q8TE67
WPRPGGQAPSSPSYE	TCF12	376	Q99081
YPYASNFLQPLPAWP	PRCP	291	P42785
VIYSPAWPLNYPPGT	LRP3	56	O75074
SWSSPPLVPFPLQYQ	LEPR	256	P48357
YPTDFSGVLQLWPPP	KIF26A	336	Q9ULI4
TAWSQPQPPPEEYAG	NAGS	51	Q8N159
YGWAVETTPSPGPQP	IRF7	236	Q92985
SYLQDPIWRGPPPTN	CYFIP2	1126	Q96F07
PPQSPTWLLYSHPVG	NEU4	371	Q8WWR8
PPPLKYLAPDGAWTF	HELZ	1671	P42694
PPGAPWAFSYLAGPP	CASKIN2	771	Q8WXE0
WAFSYLAGPPATPPD	CASKIN2	776	Q8WXE0
ESYPDLDPSWPPQST	DSG1	766	Q02413
PKYYGIWSPPTAPND	IPMK	111	Q8NFU5
PTFTGSFLSPWPPAV	SMPD4	546	Q9NXE4
GLPSYPWILTSPGFP	PRR27	71	Q6MZM9
EGPEHQAPLTYFPWP	POU2AF1	166	Q16633
QAPLTYFPWPQPLST	POU2AF1	171	Q16633
NGLRQAPSSYPPTWP	NR1D1	356	P20393
GWKYRPPPPCFSEQQ	PATL2	321	C9JE40
AHPGWPQASADSPPY	GATA6	221	Q92908
PYPNLYPDQSPSEDW	CLCN6	716	P51797
GAEAEIPPPFINPFW	CCDC63	471	Q8NA47
PGVSKLPNYNPEWFP	CDK15	326	Q96Q40
FWYPKAFSPGLPPQS	FITM2	236	Q8N6M3
PDCGFSWPLPEFDPS	FNIP1	26	Q8TF40
PSVWPDPEVYDPFRF	CYP4F8	431	P98187
LPKWPYPQAPSGPTF	GLB1L	526	Q6UWU2
ATAPCWFPPGYPEAK	REXO1L1P	96	Q8IX06
WYLATAPPAPAPPAF	AKNA	1326	Q7Z591
CTITGWSEPFPPYPV	GHRHR	96	Q02643
WARPGPFSDPVPYLE	IDUA	626	P35475
LPDVYEWPESASSPP	ME2	566	P23368
APQATPDSWPPSYGV	IL22RA1	391	Q8N6P7
PFGNGLFPYQQPPWQ	ENAM	161	Q9NRM1
YINPADLGWNPPVSS	DNAH9	2286	Q9NYC9
PYLWFNGPTMTPPPY	FOXI1	61	Q12951
GLPENIPFRSPSWYG	GTF2I	506	P78347
WPAGQPSPLDAFFLP	HPS6	71	Q86YV9
NNPGWVYIPPFDDPL	SDS	126	P20132
WYDPQLTPQPPADYG	DSEL	391	Q8IZU8
YSYGNWPPKALAPPL	PITX3	151	O75364
PASTPSLYENPWTIP	CRLS1	96	Q9UJA2
FWPAAGSLPVPSYPA	SKOR1	491	P84550
RWFPPEELNGPSPIY	USH2A	1486	O75445
NPSGYGPLTELPDWS	MRPL52	36	Q86TS9
SAWPSPGLQPPLAYI	SOX21	241	Q9Y651
PSDNYDFPPLPTDWA	SPATA22	46	Q8NHS9
PPSYPGTWNRAYSPL	SARAF	296	Q96BY9
SALPPLDWPLPSQYE	NFATC4	401	Q14934
FPGPSHTESYSWPPI	TDRD12	436	Q587J7
PALPPGPFAQNFSWG	PRDM15	176	P57071
IANSGEPWSPSYLGP	HCAR3	346	P49019
NSPWEAFPVYRQPPE	NDUFS3	236	O75489
LAASQANFYPPPPEW	PTCH2	871	Q9Y6C5
AWSYDQPPKDSPLGP	INPP5D	941	Q92835
LAWSSEDFPYSPLPP	SMIM28	106	A0A1B0GU29
AWPPGAAPAPFQYTP	SETMAR	41	Q53H47
YDTPRWATTPPPLAG	SHISA7	131	A6NL88
YFPAQCWLQPDAPGP	SWSAP1	161	Q6NVH7
LPATTPYRQPAWGGP	WHRN	116	Q9P202
GVVLSPDWPQSYSPG	SEZ6L2	536	Q6UXD5
SGTPPAPQPWYADQR	SLC38A8	136	A6NNN8
IPFPSGRTNLYWPGT	SGSH	276	P51688
PGPEIEPFSLWVFPQ	CLUHP3	56	Q96NS8
SLGDLQTWFFPPPPA	TEX44	226	Q53QW1
LSTQPAWPPPSYESI	TMEM61	166	Q8N0U2
ATPPAPTLVSGDPWY	MRPS18B	186	Q9Y676
SLPWYVPANPDSFFP	TTLL8	176	A6PVC2
PGSWEPNYPAASPDP	ZNF394	46	Q53GI3
AFWSYQLAPNPPGDP	ZFHX2	206	Q9C0A1
WNSAYQAPVPPPLGS	VGLL2	146	Q8N8G2
TRYWGPPFLQAPSGA	PIGT	96	Q969N2
LVALAPAPGFSWFPP	RNF225	236	M0QZC1
CLTPTRSFYPAPGPW	SOGA3	791	Q5TF21
SFSFGSPNPWPSRLP	STPG3	266	Q8N7X2
QSWFPPPPPGYNASS	SCEL	161	O95171
FQLSEPPDFPFWFSP	SELENON	296	Q9NZV5
PPDFPFWFSPAQFTG	SELENON	301	Q9NZV5
GPSYLWESPATDPSP	TMEM131	1761	Q92545
PVWLNFDGEPQPYPT	VHL	86	P40337
PIPIYFPPESQRGLW	MRPL28	66	Q13084
RLPQLWDPTAAPYPT	ZNF469	436	Q96JG9
GSWEPPKAHPYFPDL	LTBR	276	P36941
SPWPDAPTAYVNNSP	UBP1	311	Q9NZI7
NPYPFGIDPIWNLAS	ATP6V0A4	516	Q9HBG4
PSLSPFAPDFFPHLW	ZBTB7C	246	A1YPR0
NVAAARPYFPLPDPW	ZBTB7C	581	A1YPR0
RPYFPLPDPWAAGLA	ZBTB7C	586	A1YPR0
LLSPWAFPAAVAPPA	ZNF316	326	A6NFI3
WTSSYQPPPAPCLGG	VGLL3	151	A8MV65
VNIPPPPTDRVWYGF	TEX2	1036	Q8IWB9
GYIPEPRWDPFPLLT	PXMP4	146	Q9Y6I8
PYWADTNTRPGAHPP	nan	86	Q6ZTI0
PNSPMWYSTFPIDPG	ZMYM4	1501	Q5VZL5
TWAPSLPPILAPQAY	nan	56	Q6ZTC4
PPSIGFPYSLNEAPW	YTHDF1	61	Q9BYJ9
NEAPWSTAGDPPIPY	YTHDF1	71	Q9BYJ9
SPQAPSAGPPYGWEQ	ZNF764	136	Q96H86
PEWQSVYPFIVPYGP	N4BP2L2	266	Q92802