Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkeratin filament binding

EPPK1 FAM83H

7.08e-056442GO:1990254
DomainGDS_CDC24_CS

DNMBP PLEKHG4

3.47e-0339422IPR001331
Domain-

DCAKD NLRC5 MSH6 ZFYVE1 DICER1 NDST2

6.12e-037464263.40.50.300
PathwayREACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS

DCAKD SLC46A1 CYP8B1 AOX1

1.69e-04120334MM14771
PathwayREACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS

DCAKD SLC46A1 CYP8B1 AOX1

2.10e-04127334M27093
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

POLRMT MSH6 POM121C ZNRF3 AGBL1 DICER1 RBL1 SLC4A11 FAM83H AOX1 TNRC6A

1.03e-071116441131753913
Pubmed

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.

DICER1 RBL1

4.69e-06344220019750
Pubmed

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.

DICER1 TNRC6A

9.37e-06444228546213
Pubmed

Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.

DICER1 TNRC6A

1.56e-05544222484317
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

POLRMT MSH6 UTP3 POM121C DICER1 RPS6KC1

1.86e-0544044634244565
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

SIN3B DNMBP POM121C SVIL TNRC6A

2.03e-0526344534702444
Pubmed

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.

DICER1 RBL1

2.34e-05644222864477
Pubmed

Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells.

DICER1 TNRC6A

3.27e-05744234518544
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

PLEKHH1 KCNH7 EPPK1 ZFYVE1 RBL1

4.06e-0530444532235678
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

POLRMT NLRC5 EPPK1 DNMBP POM121C ZNRF3 PROM2 FAM83H

6.49e-05110544835748872
Pubmed

Dicer plays essential roles for retinal development by regulation of survival and differentiation.

ELAVL4 DICER1

8.54e-051144221273552
Pubmed

MRG15 is a novel PALB2-interacting factor involved in homologous recombination.

MSH6 SIN3B

1.02e-041244219553677
Pubmed

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

DICER1 TNRC6A

1.41e-041444219716330
Pubmed

Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.

DICER1 TNRC6A

1.86e-041644220102707
Pubmed

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.

MSH6 EPPK1 TNRC6A

2.06e-049044335654790
Pubmed

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

DICER1 SVIL

2.36e-041844219047128
Pubmed

Dicer is required for the transition from early to late progenitor state in the developing mouse retina.

ELAVL4 DICER1

3.89e-042344220237275
Pubmed

The functional interactome landscape of the human histone deacetylase family.

MSH6 SIN3B DICER1 SVIL

4.88e-0428944423752268
Pubmed

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.

DICER1 TNRC6A

4.99e-042644219898466
Pubmed

Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.

POLRMT MSH6 SVIL

5.39e-0412544336030824
Pubmed

Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.

DICER1 TNRC6A

6.21e-042944231330130
Pubmed

Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon.

ELAVL4 DICER1

6.65e-043044221826226
Pubmed

Members of the miRNA-200 family regulate olfactory neurogenesis.

ELAVL4 DICER1

9.06e-043544218184563
Pubmed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

TBX10 SIN3B

1.07e-033844228218735
Pubmed

A protein interaction landscape of breast cancer.

POLRMT MSH6 EPPK1 RIN2 SVIL

1.20e-0363444534591612
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

MSH6 DICER1 MTMR9

1.25e-0316744325659891
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DNMBP PLEKHG4

4.67e-0366282722
ToppCellfacs-Aorta-Heart-3m-Myeloid-professional_antigen_presenting_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK15 AGBL1 PROM2 ALOX12B

1.08e-05139444292533e04178dd36d57377562077f9deb2cb9746
ToppCellfacs-Aorta-Heart-3m-Myeloid-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLK15 AGBL1 PROM2 ALOX12B

1.08e-0513944422a769d5195ed761ef333ef542746e1ba617a698
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELAVL4 SLC46A1 ZFYVE1 RIN2

1.97e-05162444b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZFYVE1 RBL1 HYAL3 MTMR9

2.01e-05163444d2fcd6f561748f7d29a051c504f016952ba32d0f
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

PLEKHH1 PROM2 CYP8B1 SLC4A11

2.21e-051674446efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TBX10 ELAVL4 KCNH7 MAPK8IP2

3.82e-051924444d3a1c267739b1479217144656986972fc86db43
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ELAVL4 KCNH7 ADGRL3 SLC4A11

3.98e-051944442dcc3b99dbedaf8a6916891c85091ddb79d7ee31
DiseaseFuchs Endothelial Dystrophy

AGBL1 SLC4A11

1.97e-055422C0016781
DiseaseFuchs' endothelial dystrophy (is_implicated_in)

AGBL1 SLC4A11

2.96e-056422DOID:11555 (is_implicated_in)
Diseaseadseverin measurement

C1RL DNMBP

8.84e-0510422EFO_0801358
Diseasetuberculin skin test reactivity measurement, decreased susceptibility to bacterial infection

FRY ZFYVE1

1.29e-0412422EFO_0008307, EFO_0008322
Diseasediverticulitis

SVIL CCDC190

1.28e-0337422EFO_1001460
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

DCAKD AMPD3 POM121C TNRC6A

1.76e-03364424EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseThyroid carcinoma

MSH6 DICER1

1.80e-0344422C0549473
Diseasewhite matter microstructure measurement

DCAKD AMPD3 EPPK1 AGBL1

2.26e-03390424EFO_0005674
DiseaseAdenocarcinoma of lung (disorder)

MSH6 ALOX12B RPS6KC1

3.15e-03206423C0152013

Protein segments in the cluster

PeptideGeneStartEntry
ENHQPHHYTRRRIPQ

ADGRL3

1316

Q9HAR2
ATPRSYRNFRHPEIV

DNMBP

1461

Q6XZF7
RRYPGPLHHQAQRFR

ELAVL4

236

P26378
VIIPRYRNFDQPHRF

DICER1

931

Q9UPY3
FRHRPYQVITARVHP

AGBL1

791

Q96MI9
HRFPRITSQYLGHPR

AMPD3

171

Q01432
ISRYNPITKRIRHHP

AOX1

56

Q06278
RHHRSIVQLYVAPAP

SLC46A1

246

Q96NT5
RVDNVVLHRPFYPAV

MTMR9

11

Q96QG7
LARFYTVTEPQRHPR

RPS6KC1

11

Q96S38
LRQRKTYVHPIRHPS

KCNH7

1156

Q9NS40
EQTHRAVFRFIPRHP

MAPK8IP2

606

Q13387
SKARNAHYLRHRVPP

CCDC190

251

Q86UF4
RVIPHPRYEARSHRN

KLK15

91

Q9H2R5
RFRTLVAHYPPVQVL

MSH6

581

P52701
AFHQVYVPPILRRAT

NLRC5

171

Q86WI3
FVITPRRRYPIHQTQ

POM121C

201

A8CG34
RHVVQPGYPAHRRIV

DCAKD

36

Q8WVC6
RHPLPVLAYVRLTHR

HYAL3

276

O43820
NHPVHRVVVHPDYRQ

C1RL

316

Q9NZP8
YVHIPSYRPPVRRHR

ALOX12B

156

O75342
PVHHRRFLFPQQSLR

FRY

1106

Q5TBA9
LEHVSRHLRPPQYVT

FAM83H

61

Q6ZRV2
PAHGHPVIERLVTYR

UTP3

291

Q9NQZ2
PHRSSRLVPVLYHVY

POLRMT

596

O00411
FRPRNIIQRIFVHYP

ECSIT

141

Q9BQ95
QPSHDVRFRYRLHPT

CYP8B1

486

Q9UNU6
VFRHTQYPDVPTRRE

RHOXF1

121

Q8NHV9
PTHYIRRVPQRKIHY

SLC4A11

801

Q8NBS3
SVTQRRHQPAPVHYV

SVIL

326

O95425
TRHPPRVAYAFLRHR

PLEKHG4

801

Q58EX7
PRRISQQHSIYISPH

RBL1

976

P28749
PVHSHRVPVDVAYRR

EPPK1

2351

P58107
PVHSHRVPVDVAYRR

EPPK1

4486

P58107
VHVHGLPVTRYRVQY

SIN3B

1141

O75182
RTPPYQVHISHREAR

SPAG11B

66

Q08648
VQFVHRAHPAPRYRP

POM121L2

41

Q96KW2
RYQPRFHVVFVDPRK

TBX10

191

O75333
HSRPQPHIFHFVYKR

RIN2

861

Q8WYP3
RIHYPDFLVQIQRPV

PROM2

616

Q8N271
PHLRPARYRRGFIHN

NDST2

461

P52849
HPRRYRHGAPAEQLR

PLEKHH1

1176

Q9ULM0
RNHERIRLKPGHVPY

ZFYVE1

56

Q9HBF4
RVTLPVHYPGRVHRT

ZNRF3

361

Q9ULT6
RYPREVPPRFRHQEH

TNRC6A

131

Q8NDV7