Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionactin filament binding

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5 MISP TAGLN3

4.82e-052271148GO:0051015
GeneOntologyMolecularFunctionmRNA cap binding complex binding

PIWIL1 SRRT

1.92e-0441142GO:0140262
GeneOntologyMolecularFunctionankyrin binding

SPTB SPTBN4 IQCJ-SCHIP1

2.95e-04231143GO:0030506
GeneOntologyMolecularFunctionlysine N-acetyltransferase activity, acting on acetyl phosphate as donor

ATAT1 EP300

4.77e-0461142GO:0004468
GeneOntologyMolecularFunctioncytoskeletal protein binding

SPTA1 SPTB SPTBN2 ENC1 ACTN2 JAKMIP3 SPC24 SPTBN4 SPTBN5 CCDC88C MISP ALMS1 STARD9 TAGLN3 IQCJ-SCHIP1 EP300

5.06e-04109911416GO:0008092
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 RILP CCDC88C

5.35e-04281143GO:0051959
GeneOntologyMolecularFunctionnuclear androgen receptor binding

RNF6 SMARCA4 EP300

8.73e-04331143GO:0050681
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

SPTA1 SPTB SPTBN2 BFSP1 SPTBN4

9.02e-041301145GO:0005200
GeneOntologyBiologicalProcessregulation of actin filament depolymerization

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5

3.71e-08611117GO:0030834
GeneOntologyBiologicalProcessactin filament depolymerization

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5

6.47e-08661117GO:0030042
GeneOntologyBiologicalProcessnegative regulation of cytoskeleton organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 SPECC1L SPTBN4 SPTBN5 CCDC88C IQCJ-SCHIP1

9.72e-0819411110GO:0051494
GeneOntologyBiologicalProcessregulation of protein depolymerization

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 CCDC88C

9.86e-081051118GO:1901879
GeneOntologyBiologicalProcessnegative regulation of actin filament depolymerization

SPTA1 SPTB SPTBN2 SPECC1L SPTBN4 SPTBN5

3.53e-07521116GO:0030835
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L ATAT1 SPTBN4 SPTBN5 CCDC88C ALMS1 TENM1 IQCJ-SCHIP1 EP300

5.01e-0757911115GO:0051493
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

SPTA1 SPTB SPTBN2 SPECC1L SPTBN4 SPTBN5 CCDC88C

5.17e-07891117GO:1901880
GeneOntologyBiologicalProcessregulation of actin filament organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L SPTBN4 SPTBN5 ALMS1 TENM1

6.69e-0730011111GO:0110053
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L SPTBN4 SPTBN5 CCDC88C ALMS1 TENM1 EP300

6.80e-0743811113GO:1902903
GeneOntologyBiologicalProcessregulation of actin cytoskeleton organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L SPTBN4 SPTBN5 ALMS1 TENM1 EP300

1.10e-0638411112GO:0032956
GeneOntologyBiologicalProcessprotein depolymerization

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 CCDC88C

1.12e-061441118GO:0051261
GeneOntologyBiologicalProcessregulation of protein-containing complex disassembly

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 CCDC88C

1.12e-061441118GO:0043244
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

SPTA1 SPTB SPTBN2 SPECC1L SPTBN4 SPTBN5 CCDC88C

1.15e-061001117GO:0043242
GeneOntologyBiologicalProcessnegative regulation of supramolecular fiber organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 SPECC1L SPTBN4 SPTBN5 CCDC88C

1.20e-061971119GO:1902904
GeneOntologyBiologicalProcessnegative regulation of organelle organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 SPECC1L RAD50 SPC24 SPTBN4 SPTBN5 CCDC88C IQCJ-SCHIP1

2.85e-0642111112GO:0010639
GeneOntologyBiologicalProcessprotein-containing complex disassembly

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L ATAD2 SPTBN4 SPTBN5 CCDC88C SMARCA4

3.93e-0629111110GO:0032984
GeneOntologyBiologicalProcessregulation of actin filament-based process

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L SPTBN4 SPTBN5 ALMS1 TENM1 EP300

4.28e-0643811112GO:0032970
GeneOntologyBiologicalProcessactin filament capping

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

4.74e-06461115GO:0051693
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TENM1

5.23e-061771118GO:0008064
GeneOntologyBiologicalProcessregulation of actin filament length

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TENM1

5.91e-061801118GO:0030832
GeneOntologyBiologicalProcessregulation of cellular component size

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L RILP SPTBN4 SPTBN5 RNF6 TENM1 EP300

1.90e-0542611111GO:0032535
GeneOntologyBiologicalProcessactin filament organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L SPTBN4 SPTBN5 ALMS1 TAGLN3 TENM1

1.93e-0550911112GO:0007015
GeneOntologyBiologicalProcessactin polymerization or depolymerization

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TENM1

2.71e-052221118GO:0008154
GeneOntologyBiologicalProcessregulation of organelle organization

SHANK1 SPTA1 SPTB SPTBN2 CUL9 ARHGEF18 ACTN2 SPECC1L ATAT1 RAD50 SPC24 SPTBN4 SPTBN5 CCDC88C ALMS1 TENM1 SMARCA2 SMARCA4 IQCJ-SCHIP1 EP300

2.89e-05134211120GO:0033043
GeneOntologyBiologicalProcessactin filament-based process

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 CAVIN3 ACTN2 SPECC1L SPTBN4 SPTBN5 CCDC88C ALMS1 SCN3A TAGLN3 TENM1 EP300

2.97e-0591211116GO:0030029
GeneOntologyBiologicalProcessnegative regulation of actin filament polymerization

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

5.27e-05751115GO:0030837
GeneOntologyBiologicalProcesspositive regulation by host of viral transcription

CTDP1 SMARCA4 EP300

9.76e-05171113GO:0043923
GeneOntologyBiologicalProcessactin cytoskeleton organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 CAVIN3 ACTN2 SPECC1L SPTBN4 SPTBN5 ALMS1 TAGLN3 TENM1 EP300

1.04e-0480311114GO:0030036
GeneOntologyBiologicalProcessnegative regulation of protein polymerization

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

1.33e-04911115GO:0032272
GeneOntologyBiologicalProcesssupramolecular fiber organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 ACTN2 SPECC1L BFSP1 SPTBN4 SPTBN5 CCDC88C ALMS1 TAGLN3 TENM1 EP300

1.88e-0495711115GO:0097435
GeneOntologyBiologicalProcessregulation of actin filament polymerization

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 TENM1

2.00e-041561116GO:0030833
GeneOntologyBiologicalProcessnegative regulation of cellular component organization

SHANK1 SPTA1 SPTB SPTBN2 ARHGEF18 SPECC1L RAD50 SPC24 SPTBN4 SPTBN5 CCDC88C RNF6 IQCJ-SCHIP1 EP300

2.23e-0486411114GO:0051129
GeneOntologyBiologicalProcesscilium organization

DNHD1 CFAP73 SPEF2 RILP ATAT1 CCDC88C ALMS1 CFAP74 CEP131 MACIR

2.51e-0447611110GO:0044782
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex assembly

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 EP300

3.49e-041731116GO:0031333
GeneOntologyBiologicalProcessorganelle assembly

DNHD1 CFAP73 SPEF2 SPTBN2 RNF213 ACTN2 RILP ATAT1 MISP ALMS1 NRXN2 STARD9 CFAP74 CEP131 EP300 MACIR

3.84e-04113811116GO:0070925
GeneOntologyBiologicalProcessaortic smooth muscle cell differentiation

SMARCA2 SMARCA4

4.24e-0461112GO:0035887
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

CFAP73 SPEF2 CUL9 SPECC1L ATAT1 CCDC88C MISP ALMS1 STARD9 GCC2 CFAP74 CEP131

5.01e-0472011112GO:0000226
GeneOntologyBiologicalProcessregulation of anatomical structure size

SPTA1 SPTB SPTBN2 ACTN2 SPECC1L RILP SPTBN4 SPTBN5 RNF6 TENM1 EP300

5.03e-0461811111GO:0090066
GeneOntologyBiologicalProcessspermatid development

DNHD1 CFAP73 SPEF2 PIWIL1 ALMS1 SMARCA2 CEP131

5.44e-042621117GO:0007286
GeneOntologyBiologicalProcessactin filament polymerization

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 TENM1

5.74e-041901116GO:0030041
GeneOntologyBiologicalProcessregulation of androgen receptor signaling pathway

RNF6 SMARCA4 EP300

6.11e-04311113GO:0060765
GeneOntologyBiologicalProcesscell-cell adhesion

SPTA1 SPECC1L PCDH12 JAML THBS4 NRXN2 CHST4 TENM1 SMARCA2 SMARCA4 B4GALNT2 MAPK7 IL4R EP300 LILRB4

6.54e-04107711115GO:0098609
GeneOntologyBiologicalProcesscilium assembly

DNHD1 CFAP73 SPEF2 RILP ATAT1 ALMS1 CFAP74 CEP131 MACIR

6.67e-044441119GO:0060271
GeneOntologyBiologicalProcessspermatid differentiation

DNHD1 CFAP73 SPEF2 PIWIL1 ALMS1 SMARCA2 CEP131

6.79e-042721117GO:0048515
GeneOntologyBiologicalProcessnegative regulation of growth

JARID2 ALMS1 RNF6 PPT1 CTDP1 SMARCA2 SMARCA4

8.57e-042831117GO:0045926
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

DNHD1 CFAP73 SPEF2 ACTN2 RILP ATAT1 ALMS1 TENM1 CFAP74 CEP131 MACIR

9.77e-0467011111GO:0120031
GeneOntologyCellularComponentspectrin

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

5.23e-1091135GO:0008091
GeneOntologyCellularComponentcortical actin cytoskeleton

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5 MISP

7.22e-07931137GO:0030864
GeneOntologyCellularComponentcortical cytoskeleton

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5 MISP

6.50e-061291137GO:0030863
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTA1 SPTB SPTBN2

1.26e-0591133GO:0014731
GeneOntologyCellularComponentcell cortex

SPTA1 SPTB SPTBN2 ACTN2 PPFIA3 BFSP1 SPTBN4 SPTBN5 MISP

1.87e-043711139GO:0005938
DomainSpectrin

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

3.20e-09231096PF00435
DomainCH

SPEF2 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TAGLN3

1.02e-08731098PS50021
DomainCH-domain

SPEF2 SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TAGLN3

1.27e-08751098IPR001715
DomainSpectrin_repeat

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

1.46e-08291096IPR002017
DomainSpectrin/alpha-actinin

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

2.75e-08321096IPR018159
DomainSPEC

SPTA1 SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

2.75e-08321096SM00150
DomainCH

SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TAGLN3

1.00e-07651097SM00033
DomainCH

SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TAGLN3

1.68e-07701097PF00307
Domain-

SPTB SPTBN2 ACTN2 SPECC1L SPTBN4 SPTBN5 TAGLN3

1.86e-077110971.10.418.10
DomainActinin_actin-bd_CS

SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

1.91e-07231095IPR001589
DomainACTININ_2

SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

1.91e-07231095PS00020
DomainACTININ_1

SPTB SPTBN2 ACTN2 SPTBN4 SPTBN5

1.91e-07231095PS00019
DomainSpectrin_bsu

SPTB SPTBN2 SPTBN4

7.70e-0741093IPR016343
DomainPH_dom-spectrin-type

SPTBN2 SPTBN4 SPTBN5

1.58e-0591093IPR001605
DomainSnAC

SMARCA2 SMARCA4

3.37e-0521092SM01314
DomainGln-Leu-Gln_QLQ

SMARCA2 SMARCA4

3.37e-0521092IPR014978
DomainDGCR6

DGCR6 DGCR6L

3.37e-0521092PF07324
DomainSnAC

SMARCA2 SMARCA4

3.37e-0521092IPR029295
DomainSnAC

SMARCA2 SMARCA4

3.37e-0521092PF14619
DomainQLQ

SMARCA2 SMARCA4

3.37e-0521092SM00951
DomainGonadal

DGCR6 DGCR6L

3.37e-0521092IPR010849
DomainQLQ

SMARCA2 SMARCA4

3.37e-0521092PS51666
DomainQLQ

SMARCA2 SMARCA4

3.37e-0521092PF08880
DomainBROMODOMAIN_1

ATAD2 SMARCA2 SMARCA4 EP300

6.25e-05371094PS00633
DomainBromodomain

ATAD2 SMARCA2 SMARCA4 EP300

6.95e-05381094PF00439
DomainBROMODOMAIN_2

ATAD2 SMARCA2 SMARCA4 EP300

9.41e-05411094PS50014
DomainBROMO

ATAD2 SMARCA2 SMARCA4 EP300

1.04e-04421094SM00297
DomainBromodomain

ATAD2 SMARCA2 SMARCA4 EP300

1.04e-04421094IPR001487
Domain-

ATAD2 SMARCA2 SMARCA4 EP300

1.04e-044210941.20.920.10
DomainHSA

SMARCA2 SMARCA4

2.01e-0441092SM00573
DomainHSA

SMARCA2 SMARCA4

2.01e-0441092PS51204
DomainHSA_dom

SMARCA2 SMARCA4

2.01e-0441092IPR014012
DomainHSA

SMARCA2 SMARCA4

2.01e-0441092PF07529
DomainBromodomain_CS

SMARCA2 SMARCA4 EP300

4.56e-04261093IPR018359
DomainBRK

SMARCA2 SMARCA4

4.99e-0461092SM00592
DomainEF-hand_Ca_insen

SPTA1 ACTN2

4.99e-0461092IPR014837
DomainBRK_domain

SMARCA2 SMARCA4

4.99e-0461092IPR006576
DomainBRK

SMARCA2 SMARCA4

4.99e-0461092PF07533
DomainEFhand_Ca_insen

SPTA1 ACTN2

4.99e-0461092PF08726
DomainPH

SPTBN2 ARHGEF18 TEC PLCD3 SPTBN4 SPTBN5 ARHGAP20

1.23e-032781097SM00233
DomainPH_DOMAIN

SPTBN2 ARHGEF18 TEC PLCD3 SPTBN4 SPTBN5 ARHGAP20

1.25e-032791097PS50003
DomainPH_domain

SPTBN2 ARHGEF18 TEC PLCD3 SPTBN4 SPTBN5 ARHGAP20

1.28e-032801097IPR001849
DomainEF-hand-dom_pair

DTNB SPEF2 SPTA1 ACTN2 PLCD3 SCN3A RCN3

1.48e-032871097IPR011992
DomainZZ

DTNB EP300

4.86e-03181092PF00569
DomainZF_ZZ_2

DTNB EP300

4.86e-03181092PS50135
DomainZF_ZZ_1

DTNB EP300

4.86e-03181092PS01357
DomainZnf_ZZ

DTNB EP300

5.41e-03191092IPR000433
DomainZnF_ZZ

DTNB EP300

5.41e-03191092SM00291
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

1.20e-0910795MM15112
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 SCN3A

1.68e-0831796M877
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

2.11e-0638795MM14969
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

2.65e-0563795M11187
PathwayREACTOME_L1CAM_INTERACTIONS

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

3.85e-0568795MM14968
PathwayREACTOME_L1CAM_INTERACTIONS

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 SCN3A

5.89e-05121796M872
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EPHA6 SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 MAPK7 SEMA3E

1.04e-04261798MM15676
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

2.65e-04102795M27648
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EPHA6 SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 SCN3A SMARCA4 MAPK7 RPL9 SEMA3E

3.44e-045757911M29853
PathwayREACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

3.76e-04110795MM15350
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

3.27e-0918117512119179
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTB SPTBN2 SPTBN4 SPTBN5

8.50e-0813117418796539
Pubmed

alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.

SPTA1 RAD50 SPTBN4 SMARCA2 SMARCA4

1.02e-0734117516889989
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTA1 SPTB SPTBN2

1.48e-074117321412925
Pubmed

Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.

SMARCA2 SMARCA4 EP300

3.69e-075117318487222
Pubmed

A switch from hBrm to Brg1 at IFNγ-activated sequences mediates the activation of human genes.

SMARCA2 SMARCA4 EP300

1.29e-067117321079652
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTA1 SPTB SPTBN4 SPTBN5

1.46e-062511748493579
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

SPTA1 SPTB SPTBN2

4.38e-0610117322159418
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTB SPTBN2 SPTBN4

6.00e-0611117317607528
Pubmed

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.

SMARCA2 SMARCA4 ALAS2

6.00e-0611117318094026
Pubmed

Targeting HIV transcription: the quest for a functional cure.

SMARCA2 SMARCA4 EP300

6.00e-0611117325731772
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DNHD1 SPEF2 RNF213 SPECC1L RAD50 CCDC88C SMARCA4

7.03e-06208117733230847
Pubmed

Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.

RAD50 SMARCA2 SMARCA4

7.98e-0612117315140983
Pubmed

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

SMARCA2 SMARCA4

1.12e-05211728670841
Pubmed

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.

SMARCA2 SMARCA4

1.12e-052117223163725
Pubmed

Spectrin tethers and mesh in the biosynthetic pathway.

SPTA1 SPTBN2

1.12e-052117210852813
Pubmed

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

SMARCA2 SMARCA4

1.12e-052117223076393
Pubmed

A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216).

SPTA1 SPTB

1.12e-05211721391962
Pubmed

Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.

SMARCA2 SMARCA4

1.12e-05211729603422
Pubmed

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

SMARCA2 SMARCA4

1.12e-052117215576411
Pubmed

An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216).

SPTA1 SPTB

1.12e-05211722070088
Pubmed

SWI/SNF gene variants and glioma risk and outcome.

SMARCA2 SMARCA4

1.12e-052117223276717
Pubmed

Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.

SMARCA2 SMARCA4

1.12e-052117227097303
Pubmed

Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

SMARCA2 SMARCA4

1.12e-052117215240517
Pubmed

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

SMARCA2 SMARCA4

1.12e-052117226564006
Pubmed

SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.

SMARCA2 SMARCA4

1.12e-052117233027072
Pubmed

SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.

SMARCA2 SMARCA4

1.12e-052117228038711
Pubmed

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

SMARCA2 SMARCA4

1.12e-052117223872584
Pubmed

Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.

DGCR6 DGCR6L

1.12e-052117222832905
Pubmed

Utilization of spectrins βI and βIII in diagnosis of hepatocellular carcinoma.

SPTB SPTBN2

1.12e-052117230798076
Pubmed

Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.

SMARCA2 SMARCA4

1.12e-052117223963727
Pubmed

Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin.

SPTA1 SPTB

1.12e-052117215492010
Pubmed

Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1.

SPTA1 SPTB

1.12e-05211728102379
Pubmed

SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.

SMARCA2 SMARCA4

1.12e-052117212493776
Pubmed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

SMARCA2 SMARCA4

1.12e-052117231375262
Pubmed

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.

SMARCA2 SMARCA4

1.12e-052117223088494
Pubmed

Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.

SMARCA2 SMARCA4

1.12e-052117217075831
Pubmed

Beta-spectrin Promiss-ao: a translation initiation codon mutation of the beta-spectrin gene (ATG --> GTG) associated with hereditary spherocytosis and spectrin deficiency in a Brazilian family.

SPTA1 SPTB

1.12e-05211729414314
Pubmed

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

SMARCA2 SMARCA4

1.12e-052117220333683
Pubmed

SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.

SMARCA2 SMARCA4

1.12e-052117234812766
Pubmed

Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis.

SPTA1 SPTB

1.12e-05211729373273
Pubmed

Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.

SPTA1 SPTB

1.12e-05211729005995
Pubmed

Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis.

SPTA1 SPTB

1.12e-05211727104494
Pubmed

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

SMARCA2 SMARCA4

1.12e-052117232855269
Pubmed

A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis.

SPTA1 SPTB

1.12e-05211726215583
Pubmed

Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.

SMARCA2 SMARCA4

1.12e-052117230478150
Pubmed

Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia.

SPTA1 SPTB

1.12e-052117230198572
Pubmed

Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis.

SPTA1 SPTB

1.12e-05211728844207
Pubmed

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

SMARCA2 SMARCA4

1.12e-052117222721696
Pubmed

Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation.

SPTA1 SPTB

1.12e-05211722056132
Pubmed

Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.

DGCR6 DGCR6L

1.12e-052117215821931
Pubmed

Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.

SMARCA2 SMARCA4

1.12e-052117218508913
Pubmed

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

SMARCA2 SMARCA4

1.12e-052117211719516
Pubmed

Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis.

SPTA1 SPTB

1.12e-05211722346784
Pubmed

Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis.

SPTA1 SPTB

1.12e-05211723580577
Pubmed

Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.

SPTA1 SPTB

1.12e-05211727883966
Pubmed

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

SMARCA2 SMARCA4

1.12e-052117225808524
Pubmed

Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.

SMARCA2 SMARCA4

1.12e-052117219144648
Pubmed

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

SMARCA2 SMARCA4

1.12e-052117228706277
Pubmed

Spectrin Cosenza: a novel beta chain variant associated with Sp alphaI/74 hereditary elliptocytosis.

SPTA1 SPTB

1.12e-05211729163587
Pubmed

[Expression of BRG1 and BRM proteins in prostatic cancer].

SMARCA2 SMARCA4

1.12e-052117221092585
Pubmed

Identification of three novel spectrin alpha I/74 mutations in hereditary elliptocytosis: further support for a triple-stranded folding unit model of the spectrin heterodimer contact site.

SPTA1 SPTB

1.12e-05211728018926
Pubmed

Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.

DGCR6 DGCR6L

1.12e-052117211157784
Pubmed

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.

SMARCA2 SMARCA4

1.12e-052117229391527
Pubmed

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.

SMARCA2 SMARCA4

1.12e-052117237634210
Pubmed

SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

SMARCA2 SMARCA4

1.12e-052117226551623
Pubmed

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SMARCA2 SMARCA4

1.12e-052117219458193
Pubmed

A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed in early embryogenesis and is the homolog of a human gene deleted in DiGeorge syndrome.

DGCR6 DGCR6L

1.12e-05211729605865
Pubmed

Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

SMARCA2 SMARCA4

1.12e-05211728208605
Pubmed

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.

SMARCA2 SMARCA4

1.12e-052117234289068
Pubmed

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

SMARCA2 SMARCA4

1.12e-052117234518526
Pubmed

SMARCA family of genes.

SMARCA2 SMARCA4

1.12e-052117232312722
Pubmed

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

SMARCA2 SMARCA4

1.12e-052117226356327
Pubmed

Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.

SPTA1 SPTB

1.12e-05211728226774
Pubmed

Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site.

SPTA1 SPTB

1.12e-05211721634521
Pubmed

Erythrocyte spectrin is comprised of many homologous triple helical segments.

SPTA1 SPTB

1.12e-05211726472478
Pubmed

Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.

SPTA1 SPTB

1.12e-052117222164239
Pubmed

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

SMARCA2 SMARCA4

1.12e-052117212566296
Pubmed

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

SMARCA2 SMARCA4

1.12e-052117211163203
Pubmed

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.

SMARCA2 SMARCA4

1.12e-052117212620226
Pubmed

Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.

SPTA1 SPTB

1.12e-052117220197550
Pubmed

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

SMARCA2 SMARCA4

1.12e-052117231406271
Pubmed

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

SMARCA2 SMARCA4

1.12e-052117227039070
Pubmed

Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.

SMARCA2 SMARCA4

1.12e-052117229848589
Pubmed

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.

SMARCA2 SMARCA4

1.12e-052117229273066
Pubmed

A structural model of the erythrocyte spectrin heterodimer initiation site determined using homology modeling and chemical cross-linking.

SPTA1 SPTB

1.12e-052117217977835
Pubmed

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.

SMARCA2 SMARCA4 EP300

1.64e-0515117314701856
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SHANK1 SPTBN2 ARHGEF18 SPECC1L JAKMIP3 PPFIA3 RAD50 SPTBN4 CCDC88C TAGLN3 STON2 SMARCA4 CEP131

2.26e-059631171328671696
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ADAMTS1 GPATCH2 L1TD1 CUL9 RNF213 PPFIA3 POM121C RAD50 ALMS1 SMARCA2 SMARCA4 CKAP4 CLSPN EP300

2.41e-0511161171431753913
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

SMARCA2 SMARCA4 EP300

2.44e-0517117319183483
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SHANK1 SPTA1 SPTB SPTBN2 ACTN2 SPECC1L PPFIA3 SPTBN4 SRRT MISP THBS4 NRXN2 TAGLN3 STON2 SMARCA4 DAGLA

2.49e-0514311171637142655
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SPTBN2 SPECC1L ALMS1 GCC2 SEMA3E

2.79e-0510411759205841
Pubmed

TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.

SMARCA2 SMARCA4 EP300

2.92e-0518117328068325
Pubmed

A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.

SPTB SPTBN4

3.36e-053117211294830
Pubmed

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.

SMARCA2 SMARCA4

3.36e-053117228292935
Pubmed

Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.

SMARCA2 SMARCA4

3.36e-053117236464671
Pubmed

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

SMARCA2 SMARCA4

3.36e-053117230287812
Pubmed

Spectrin's E2/E3 ubiquitin conjugating/ligating activity is diminished in sickle cells.

SPTA1 SPTB

3.36e-053117215929114
Pubmed

Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo.

SPTA1 SPTB

3.36e-05311721385865
Pubmed

POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.

POM121C POM121

3.36e-053117230802453
InteractionSPTA1 interactions

SPTA1 SPTB SPTBN2 DGCR6L RAD50 SPTBN4 SMARCA2 SMARCA4

5.29e-08941128int:SPTA1
GeneFamilyEF-hand domain containing|Spectrins

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

7.09e-1276051113
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTB SPTBN2 ARHGEF18 TEC SPTBN4

6.01e-04206605682
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DTNB EP300

1.60e-031860291
GeneFamilySterile alpha motif domain containing

SHANK1 EPHA6 PPFIA3

3.12e-0388603760
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPECC1L PPFIA3 SGK2 MISP STON2 B4GALNT2 MACIR

4.29e-0717611777622f5a8e7320cc7b593141854107ecaf4adff7f
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SPTA1 SPTB RILP SPC24 BNC1 ALAS2

4.31e-0616111768ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCellfacs-SCAT-Fat-18m-Epithelial|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 PPFIA3 SGK2 MISP B4GALNT2 ALAS2

4.47e-061621176341fa357ad7bdbef30864e8062f161e60185ffc9
ToppCellfacs-SCAT-Fat-18m-Epithelial-epithelial_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 PPFIA3 SGK2 MISP B4GALNT2 ALAS2

4.47e-0616211767215f6eb2b65dea455e2eec722a9c38e6958b120
ToppCellfacs-SCAT-Fat-18m-Epithelial-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 PPFIA3 SGK2 MISP B4GALNT2 ALAS2

4.47e-0616211767fa93efa2039d68a4e8214fa143bcd3368349a2d
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD16|GI_small-bowel / Manually curated celltypes from each tissue

ADAMTS1 ENC1 BFSP1 CPT1C TENM1 DTHD1

6.09e-0617111761ee505b91f15191d294a5d491ecdf154c08b8622
ToppCell356C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

L1TD1 SPECC1L JAML BFSP1 SPTBN5 IQCJ-SCHIP1

6.09e-0617111763d26ef58fe5231373d7df9ac79d225546918cf82
ToppCellAdult-Immune-enucleated_erythrocyte-D231|Adult / Lineage, Cell type, age group and donor

TMED1 SPTB CAVIN3 ACTN2 PCDH12 ALAS2

7.42e-06177117615ee303fb6caea1fd645c3b777666196ce500a1c
ToppCellfacs-Limb_Muscle-Muscle_Diaphragm-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2E1 ECM2 CAVIN3 THBS4 CHST4 RCN3

9.84e-061861176a66da8453bb78f7e9f5f59452b3c50ae679d83c3
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTB SPTBN2 ETNPPL NRXN2 KCNK3 TMEM266

9.84e-061861176a1ab273b01971d6a892912560d387685dd657179
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTB SPTBN2 ETNPPL NRXN2 KCNK3 TMEM266

1.01e-051871176ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGCR6 EPSTI1 PPT1 NIM1K CFAP74 STX6

1.14e-0519111764bd9db45e7b5c0d04368e08c8199d390744aa317
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ENC1 ATAT1 SCN3A TAGLN3 RPL9

1.17e-0511211759c3fb470708e76a8f8a3cb9aa17ab130c60fee11
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-8|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

SHANK1 ECM2 ACTN2 PCDH12 THBS4 RCN3

1.25e-05194117655b97095a7a17a312c616703d291738a0f806339
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

SPTA1 SPTB ATAD2 SPC24 ALAS2 CLSPN

1.29e-051951176764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPEF2 RNF213 SFI1 STARD9 TENM1 DTHD1

1.36e-051971176e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell21-Trachea-RBC|Trachea / Age, Tissue, Lineage and Cell class

SPTA1 SPTB RILP SPC24 ALAS2 CLSPN

1.36e-0519711769f8eb6305ade0654bbcd8f19963be0b64af083de
ToppCell21-Trachea-RBC-RBC|Trachea / Age, Tissue, Lineage and Cell class

SPTA1 SPTB RILP SPC24 ALAS2 CLSPN

1.36e-0519711764710b55806a618076a954190f519e49c55d300d3
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

ACTN2 SPTBN4 NRXN2 TENM1 ALAS2 ARHGAP20

1.49e-05200117661d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

SYCP2L SNX20 L1TD1 IGFALS CKAP4

3.21e-051381175e1e936ff4080bda2810c5fd1154a706359f377a5
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUL9 ATAD2 NIM1K MAPK7 RCN3

3.44e-051401175e442c46979d725ec82f525a001c46d971fcade4d
ToppCellLPS-antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ENC1 PLCD3 CPT1C CLSPN LILRB4

3.81e-05143117557ee1830d96d73d92b5f83b028592a5d952c6013
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BICDL2 PRSS16 JAML PLCD3 MACIR

4.20e-051461175bb7bf20245d93c8812920dd0debbf1ed00add378
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Cortical_neuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ENC1 ATAT1 SCN3A TAGLN3 SMARCA4

4.48e-051481175a1269312903fc27830c1835dabf660c659a711be
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|356C / Donor, Lineage, Cell class and subclass (all cells)

SPTA1 SPTB SPC24 BNC1 ALAS2

4.78e-0515011756bdf9df586f348641a25a445e83a41e47e7f347e
ToppCell356C-Lymphocytic-ILC-ILC-2|356C / Donor, Lineage, Cell class and subclass (all cells)

L1TD1 SPECC1L BFSP1 SPTBN5 IQCJ-SCHIP1

5.59e-0515511750fd66c623cb433ceaa893bc21ba2e3b394faaf70
ToppCelldroplet-Fat-Mat-18m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETNPPL PPFIA3 SGK2 MISP B4GALNT2

5.76e-051561175cfd7f56f3155db677684827607e9008e975dbe70
ToppCelldroplet-Fat-Mat-18m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETNPPL PPFIA3 SGK2 MISP B4GALNT2

5.76e-0515611750d79b4172896574b00faf00e87254f68d76f5512
ToppCelldroplet-Fat-Mat-18m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETNPPL PPFIA3 SGK2 MISP B4GALNT2

5.76e-051561175f09150aacb6121f913648ed3918f9cd4f22c61f2
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-5|TCGA-Colorectal / Sample_Type by Project: Shred V9

PRSS16 L1TD1 FBXO16 IGFALS CKAP4

5.94e-0515711755fb41af247465aa29aa7b8edd26e3d3794766f80
ToppCellfacs-Limb_Muscle-Muscle_Diaphragm-18m-Lymphocytic-B_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 SNX20 ARHGEF18 SFI1 MISP

6.30e-051591175656aa20706bdba81bbcc3e68e6058215b92b8802
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PODNL1 EPSTI1 SNX20 JAML LILRB4

6.69e-05161117554eda81a570e422b35fcea799e640c7654122969
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-hematologic-erythrocytic-erythrocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPTA1 SPTB IGFALS ALAS2 MAPK7

6.89e-05162117525a11e4c6304324310b33a33331ebc812d045d4a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATAD2 SPC24 C1orf185 CLSPN IL27

7.09e-0516311753f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PODNL1 EPSTI1 PRSS16 JAML CFAP74

7.30e-051641175731b9c7d6f6ecfb14d4a8705e0ddac9fb460d9a8
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM2 NRXN2 SCN3A TAGLN3 NIM1K

7.51e-051651175347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM2 NRXN2 SCN3A TAGLN3 NIM1K

7.51e-051651175507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM2 NRXN2 SCN3A TAGLN3 NIM1K

7.51e-05165117539a25be081a5d59c7cf107a997d352793d5025fb
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ECM2 NRXN2 SCN3A TAGLN3 NIM1K

7.51e-0516511751890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellfacs-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 SPTA1 SPTB SPC24 ALAS2

7.73e-0516611758d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCellfacs-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 SPTA1 SPTB SPC24 ALAS2

7.73e-051661175f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCellfacs-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 SPTA1 SPTB SPC24 ALAS2

7.73e-051661175a5074c96c6561273029aceb93402a7e038140f50
ToppCellfacs-Large_Intestine-Proximal|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX20 PPFIA3 SGK2 B4GALNT2 ARHGAP20

8.18e-05168117523e0e1592d7400012d289adb10c7598285bae2e9
ToppCellNS-moderate-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SYCP2L SNX20 WNT6 JAML LILRB4

8.18e-051681175d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-erythrocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPTA1 SPTB RILP KCNQ4 ALAS2

8.18e-051681175360cd756067c8cfb6a78301674758eb5fac52c23
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SPTA1 SPTB RILP KCNQ4 ALAS2

8.18e-051681175d791116040a9d3ea0485d68c974340116073986b
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8|GI_small-bowel / Manually curated celltypes from each tissue

ENC1 TSPYL6 SPTBN4 SRRT DTHD1

8.41e-05169117517568e7aacfdcd96c469bae57d5ffad04954e9bd
ToppCelldroplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTA1 ARHGEF18 BNC1 CCDC88C ALAS2

8.41e-051691175c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPEF2 CCDC88C CROCC2 CFAP74 DTHD1

8.41e-05169117514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAVIN3 PPFIA3 SGK2 STON2 MACIR

8.89e-0517111755d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-Red_blood_cells-RBC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPTA1 SPTB RILP NIM1K ALAS2

8.89e-051711175f21eae4dd2e0a566eff792d19367e96ffb0b74ba
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-Red_blood_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPTA1 SPTB RILP NIM1K ALAS2

8.89e-051711175d428c2859a1efc284610ca241a6dae9f182309cd
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ATAD2 SPC24 NIM1K CFAP74 CLSPN

9.13e-0517211756fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 EPSTI1 ARHGEF18 IL4R LILRB4

9.39e-0517311757c5e4809205ce1a0a301c15442af00a2e2b9b301
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF18 NRXN2 TAGLN3 NIM1K STON2

9.64e-051741175742c73c9e090848b464323cb17579b86658c6792
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPECC1L PPFIA3 MISP B4GALNT2 MACIR

9.64e-0517411752fbdb62e269acf4447b171700a615e878dde7f9f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPECC1L PPFIA3 MISP B4GALNT2 MACIR

9.64e-0517411757c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PODNL1 SNX20 ACTN2 JAML LILRB4

9.64e-051741175773329bb91b97578df138446cf62101dd0dad758
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF18 NRXN2 TAGLN3 NIM1K STON2

9.64e-0517411757fed9722e64c60843092f2ba71256e3043011ef6
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 KCTD4 CAVIN3 PCDH12 TAGLN3

9.91e-0517511750801cccec6915aefc135262fc74580280fd51aa5
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ECM2 KCTD4 CAVIN3 PCDH12 TAGLN3

9.91e-05175117509163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPATCH2 PCDH12 ATAT1 PLCD3 CKAP4

1.05e-041771175c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPATCH2 PCDH12 ATAT1 PLCD3 CKAP4

1.05e-041771175ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS1 WNT6 KCNQ4 STARD9 KCNK3

1.05e-041771175452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCellLA-17._Lymphocyte|World / Chamber and Cluster_Paper

SYCP2L JAML CCDC88C ALAS2 DTHD1

1.07e-04178117534ec499d03cc198cfefa19a724d4c81974052f65
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAKMIP3 SCN3A TAGLN3 TEC SEMA3E

1.10e-0417911757c8a2fa1326c73dc9e774df645b572864fd97133
ToppCellwk_08-11-Hematologic-Meg-ery-Primitive_erythrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SPTA1 SPTB RILP NIM1K ALAS2

1.10e-0417911753c8046f43da5a02fa4278a7175b9cd8cf95b8e27
ToppCellCV-Severe-4|Severe / Virus stimulation, Condition and Cluster

BICDL2 CAVIN3 NIM1K MACIR RCN3

1.13e-041801175cf84a01e6a33e5d27ad7be1d9069a0370b5116d1
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A TAGLN3 KCNK3 SMARCA2 TEC

1.13e-0418011758bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCell356C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

SPTA1 SPC24 STON2 CLSPN MACIR

1.16e-041811175be4f35c9eb5b3083acb2264128f095fac1f3da45
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.19e-0418211757ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.19e-041821175fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPTB ETNPPL ACTN2 JAKMIP3 IQCJ-SCHIP1

1.22e-0418311752902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PRSS16 C1orf167 SPC24 FBXO16 ALAS2

1.22e-041831175dd15e1463a0d57d14800de0df0645c81c56926ae
ToppCellwk_08-11-Hematologic-Meg-ery|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SPTA1 SPTB RILP NIM1K ALAS2

1.22e-0418311757eecb8d80e31ca26c2e6ce43bf0f2c71be1643e4
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PRSS16 C1orf167 SPC24 FBXO16 ALAS2

1.22e-0418311758ace19c38b89556d2504258a63aa5a2b14f5cd36
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGCR6 EPSTI1 CFAP74 TEC STX6

1.22e-0418311756a15ffb56381b724ef4d574e7b2835e00e1a0092
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAVIN3 FBXO16 BNC1 ARHGAP20 RCN3

1.22e-041831175ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCellCOVID-cycling-|COVID / Condition, Cell_class and T cell subcluster

SPTA1 ATAD2 SPC24 ALAS2 CLSPN

1.29e-041851175eb74b8d36f7b749e04bc2ed4b36f7e1ac7bb6d5f
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.29e-04185117530f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.29e-04185117518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellCOVID-cycling|COVID / Condition, Cell_class and T cell subcluster

SPTA1 ATAD2 SPC24 ALAS2 CLSPN

1.29e-0418511755112f966735fa48f0606adcfd5c0212ad5d3d77a
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

CAVIN3 SPC24 CKAP4 CLSPN LILRB4

1.32e-041861175e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ENC1 RTF1 ALMS1 GCC2 EP300

1.32e-04186117503db813598b67b1e08f759758a1c2023396921fa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH12 SPTBN5 STARD9 CLSPN IL4R

1.35e-04187117535c382c0aabd46906113e5db30ea24bb8e658899
ToppCell3'_v3-GI_small-bowel-Lymphocytic_NK-Cycling_NK|GI_small-bowel / Manually curated celltypes from each tissue

CFAP73 ATAD2 SPC24 ZNF665 CLSPN

1.35e-041871175265c690c2921fd201361a0ec8bc4d2a996fbcaf4
ToppCell10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega-Erythrocytic_early|lymph-node_spleen / Manually curated celltypes from each tissue

SPTA1 SPTB SPTBN2 SPC24 ALAS2

1.35e-04187117561d346c9873c2edb3ce224a0c063c54d9a68309e
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.39e-04188117561a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.39e-04188117534b11f72ca73153d02edcd09b38983ad1a504659
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.39e-0418811752b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

THBS4 CPT1C TENM1 ARHGAP20 SEMA3E

1.39e-0418811750e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.42e-041891175a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.42e-04189117568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellControl-Epithelial-Ciliated|Control / Disease state, Lineage and Cell class

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.42e-041891175c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SCN3A TAGLN3 SMARCA2 SEMA3E

1.42e-041891175fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTB SPTBN2 SPTBN4 NRXN2 TAGLN3

1.42e-041891175f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.42e-041891175b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.42e-04189117527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CFAP73 SPEF2 CROCC2 CFAP74 DTHD1

1.42e-0418911753e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SCN3A TAGLN3 RCN3 SEMA3E

1.46e-041901175e792e42fc49472eaf974eb0905819eb51a1da8e5
DrugADPribulose

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

3.59e-09131145CID000197570
Drug2-nitro-5-thiocyanobenzoic acid

DTNB SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

1.43e-07481146CID000092266
Drugmaleimide

DTNB SPTA1 SPTB SPTBN2 CAVIN3 SPTBN4 SPTBN5 STX6

3.20e-071311148CID000010935
Drugdimethyl adipimidate

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

3.71e-07301145CID000025738
DrugPRODAN

SPTA1 SPTBN2 SPTBN4 SPTBN5

7.80e-07151144CID000028127
Drug6-propionyl-2-(dimethylamino)naphthalene

SPTA1 SPTB SPTBN2 SPTBN5

1.04e-06161144CID000107729
Drugphenylhydrazine

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5 ALAS2

3.55e-06821146CID000007516
DrugAC1L1HCM

SPTA1 SPTB SPTBN2 SPTBN5

4.07e-06221144CID000004072
DrugMDL 28170

SPTA1 SPTB SPTBN2 SPTBN5 CAPN7

7.49e-06541145CID000072430
Drugdimyristoylphosphatidylcholine

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

1.74e-05641145CID000026197
DrugDimethadione

CYP2E1 JARID2

2.49e-0521142ctd:D004114
DrugB202

DGCR6 DGCR6L

2.49e-0521142CID006435965
Drugspermine

SPTA1 SPTB SPTBN2 PLCD3 SPTBN4 SPTBN5 STON2 KCNK3 B4GALNT2 CEP131

2.96e-0539411410CID000001103
DrugAC1L1DW2

CYP2E1 SPTA1 SPTB SPTBN2 BFSP1 SPTBN5 CAPN7

4.27e-051861147CID000002532
DrugMephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; HL60; HT_HG-U133A

ADAMTS1 TEC SRRT RNF6 TSR1 STX6 RCN3

5.40e-0519311472563_DN
Drugplakin

SPTA1 SPTB SPTBN2 SPTBN4 SPTBN5

5.78e-05821145CID000018752
DrugDeptropine citrate [2169-75-7]; Up 200; 7.6uM; HL60; HT_HG-U133A

DTNB SPTB SFI1 RNF6 SMARCA4 IL4R RCN3

5.95e-0519611473144_UP
DrugDeoxycorticosterone [64-85-7]; Down 200; 12.2uM; PC3; HT_HG-U133A

ENC1 RTF1 RNF6 TAGLN3 SMARCA2 DAGLA RCN3

6.15e-0519711476758_DN
DrugTrichlormethiazide [133-67-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A

PODNL1 ETNPPL SFI1 SRRT IGFALS TAGLN3 TENM1

6.35e-0519811474783_UP
DrugErgocryptine-alpha [511-09-1]; Up 200; 7uM; MCF7; HT_HG-U133A

CYP2E1 ACTN2 SGK2 SPTBN5 IGFALS TAGLN3 SEMA3E

6.35e-0519811474374_UP
DrugTetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; HL60; HG-U133A

PODNL1 RTF1 TSR1 SMARCA4 CFAP74 CKAP4 STX6

6.55e-0519911471756_DN
DrugBambuterol hydrochloride [81732-46-9]; Up 200; 10uM; HL60; HG-U133A

DTNB SPTB SFI1 SGK2 MISP CTDP1 LILRB4

6.55e-0519911471582_UP
Drug[[(2R,3S,4R,5R)-5-(6-amino-1,2,7,8-tetrahydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-[(3S,4S)-3-carbamoyl-4-[hydroxy-[(4S)-2-propyl-3,4-dihydropyridin-4-yl]methyl]piperidin-1-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

KCNK3 B4GALNT2

7.43e-0531142CID015942691
DrugAC1OAGFB

SPTA1 SPTB SPTBN2 CAVIN3 PLCD3 SPTBN4 SPTBN5 FBXO16 SCN3A KCNK3 DAGLA

8.44e-0553911411CID006857345
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTB SPTBN2 SPTBN4

2.12e-0741123DOID:0050882 (implicated_via_orthology)
DiseaseHereditary elliptocytosis

SPTA1 SPTB

8.53e-0541122cv:C0013902
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

8.53e-0541122EFO_0020830
DiseaseAnemia, hereditary spherocytic hemolytic

SPTA1 SPTB

1.42e-0451122C0221409
Diseasehereditary spherocytosis (is_implicated_in)

SPTA1 SPTB

1.42e-0451122DOID:12971 (is_implicated_in)
DiseaseHereditary spherocytosis

SPTA1 SPTB

1.42e-0451122cv:C0037889
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCA2 SMARCA4

1.42e-0451122C3281201
Diseaseproline measurement, amino acid measurement

DGCR6 DGCR6L

1.42e-0451122EFO_0005134, EFO_0009773
DiseaseElliptocytosis, Hereditary

SPTA1 SPTB

2.12e-0461122C0013902
DiseaseHereditary spherocytosis

SPTA1 SPTB

3.94e-0481122C0037889
Disease2-aminooctanoate measurement

ALMS1 TMEM266

3.94e-0481122EFO_0800349
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCA2 SMARCA4

5.05e-0491122DOID:0050340 (implicated_via_orthology)
Diseasecholesteryl ester 20:5 measurement

SYCP2L CKAP4 DAGLA

6.29e-04441123EFO_0010349
Disease2-ketocaprylate measurement

ALMS1 TMEM266

6.30e-04101122EFO_0800110
DiseaseN-acetyl-2-aminooctanoate measurement

ALMS1 TMEM266

9.19e-04121122EFO_0800567
DiseaseCoffin-Siris syndrome

SMARCA2 SMARCA4

1.08e-03131122C0265338
Diseaselysophosphatidylcholine 22:5 measurement

NRBF2 DAGLA

1.26e-03141122EFO_0021462
DiseasePapillary Renal Cell Carcinoma

SHANK1 DNHD1 SPTBN4 IL4R

1.46e-031281124C1306837
DiseaseRenal Cell Carcinoma

SHANK1 DNHD1 SPTBN4 IL4R

1.46e-031281124C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

SHANK1 DNHD1 SPTBN4 IL4R

1.46e-031281124C1266043
DiseaseChromophobe Renal Cell Carcinoma

SHANK1 DNHD1 SPTBN4 IL4R

1.46e-031281124C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

SHANK1 DNHD1 SPTBN4 IL4R

1.46e-031281124C1266044
Diseasesevere acute respiratory syndrome, COVID-19

DTNB SPEF2 ARHGEF18 JARID2 ZNF665 IQCJ-SCHIP1 STX6

1.62e-034471127EFO_0000694, MONDO_0100096
Diseaseallergic rhinitis

SYCP2L SPEF2 RAD50 RTF1

1.68e-031331124EFO_0005854
DiseaseSchizophrenia

SHANK1 DGCR6 CYP2E1 PRSS16 SPTBN2 ETNPPL JARID2 NRXN2 STON2 SMARCA2

1.99e-0388311210C0036341
Diseaseacetone measurement

CYP2E1 NIM1K

2.34e-03191122EFO_0010989
Diseasecystathionine measurement

TEC TEC

2.34e-03191122EFO_0010474
Diseaseabnormal paneth cell measurement

SPEF2 IQCJ-SCHIP1

2.34e-03191122EFO_0007963
Diseasecolorectal cancer, inflammatory bowel disease

ALMS1 KCNQ4

2.34e-03191122EFO_0003767, MONDO_0005575
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

SHANK1 DNHD1 SPTBN4 IL4R

2.48e-031481124C0279702
Diseaseleprosy, Crohn's disease

SNX20 IL27

2.59e-03201122EFO_0000384, EFO_0001054
Diseaseskin hydration measurement

PIWIL1 DTHD1

2.86e-03211122EFO_0009586
DiseaseNon-Small Cell Lung Carcinoma

CYP2E1 ADAMTS1 SMARCA4 MACIR

3.00e-031561124C0007131
Diseaseprostate cancer (is_marker_for)

SMARCA2 SMARCA4 MAPK7 EP300

3.00e-031561124DOID:10283 (is_marker_for)
DiseaseAlcoholic Intoxication, Chronic

CYP2E1 PCDH12 TAGLN3 STON2 EP300

3.63e-032681125C0001973

Protein segments in the cluster

PeptideGeneStartEntry
AEQLGREDQQRLHRN

CTDP1

166

Q9Y5B0
FLENRVNDFLRRQNH

EP300

1301

Q09472
LRAQHQAFQDGLRRR

C1orf167

1041

Q5SNV9
VLQELRQYHGARQRA

ARHGEF18

206

Q6ZSZ5
RQHANERLRRQFAAQ

ACTN2

631

P35609
ERLRRQFAAQANAIG

ACTN2

636

P35609
RRAAQVQRLEANHGL

CAVIN3

101

Q969G5
HQDFSRQREELGQGL

CKAP4

141

Q07065
ARRQAEFEHFQRREG

B4GALNT2

166

Q8NHY0
VGQHALARQIEENRF

BNC1

706

Q01954
RDALFNIDRERQGHQ

ALMS1

4076

Q8TCU4
RNFHTGRFQLQEEQR

C1orf185

76

Q5T7R7
NARFEREQLLGVQQH

SPECC1L

501

Q69YQ0
LGHNRIRQLAERSFE

IGFALS

321

P35858
NGRHFTRQLARQQAD

ATAD2

101

Q6PL18
LARQRDALQAQREAF

DNHD1

3206

Q96M86
VADGARQQERHYQLL

DGCR6

11

Q14129
NRALRRAAEERHQAG

CFAP73

96

A6NFT4
VQNALEVNLRHFRRG

DMXL1

306

Q9Y485
NDLALRLARQFRGHQ

ETNPPL

116

Q8TBG4
RQQFRDFRDLNKDGH

RCN3

246

Q96D15
GRLQLQADRHQEHIR

RAD50

351

Q92878
ELRAHNRDLRQRGQE

RILP

126

Q96NA2
QGNESRIQREAHFLL

CYP2E1

141

P05181
LQFHLLRRNRQGDVG

ADAMTS1

181

Q9UHI8
EERRRQAGAAFQVLQ

PCDH12

56

Q9NPG4
DLREQRGLRQATDHQ

MISP

306

Q8IVT2
EDFHARREGIRQQIR

MAPK7

386

Q13164
GKHRTLAQRQADFQR

LILRB4

286

Q8NHJ6
RDAEHRALLTRNGQA

KCNK3

256

O14649
RHGNFEERLRQLEAQ

PPFIA3

391

O75145
QNLRDRFRSQILQHF

LONRF1

696

Q17RB8
LLFEHVQRARNGGLR

KCNQ4

381

P56696
NQRLRGELDRVNFLH

CCDC88C

1251

Q9P219
HRRVNNAFLDRLQGK

EPSTI1

281

Q96J88
FLINRQLGRHRSDID

ETDB

36

P0DPP9
QHLTLRGDRVFARNN

MACIR

191

Q96GV9
RDGLLFRHVLNFLRN

KCTD4

81

Q8WVF5
ERELGVQAGHAQRLQ

JAKMIP3

226

Q5VZ66
ITEEHIRNNQGRDAR

NIM1K

366

Q8IY84
LERRRAQGQAHDQQL

FAM170B

241

A6NMN3
EEGQALRRAHQRNVK

ALAS2

441

P22557
AHQQSRRADRLLAAG

NRBF2

11

Q96F24
DQIFLDGQENKRRRH

POM121C

306

A8CG34
AGNFDNERLAIARQR

NRXN2

206

P58401
RNHSIFLADINQERG

PPT1

196

P50897
RNRIRQVEAARLHGA

PODNL1

296

Q6PEZ8
IFLDGQENKRRRHDS

POM121

331

Q96HA1
FIQIALQLAHFRDRG

CPT1C

566

Q8TCG5
EQILRRNVLQHGAAA

IL4R

551

P24394
VQFARLAVQRDHEGR

CAPN7

11

Q9Y6W3
QRLQEHLRESRGAEQ

CROCC2

1221

H7BZ55
LEQRHAGLRRQLDAF

BFSP1

61

Q12934
NEVLRNSFRDQVRHL

GCC2

1436

Q8IWJ2
DLQRHLRFQVLAAGF

IL27

146

Q8NEV9
DVQEAFAQGTRRNLR

DTNB

571

O60941
VADGARQQERHYQLL

DGCR6L

11

Q9BY27
SRHFQVREGEQLLLR

DTHD1

551

Q6ZMT9
LQQENHELRRGLAAR

BICDL2

96

A1A5D9
EERRLAHQQQRQGRE

ECM2

256

O94769
GDILNARFIRNLQER

ATAT1

401

Q5SQI0
NLRTYNLRHRLEEGQ

DAGLA

176

Q9Y4D2
FLINRQLGRHRSDID

ETDA

36

Q3ZM63
PRLNRVLRHEQNFAD

CUL9

1341

Q8IWT3
QQRLFTDVLLHAGNR

ENC1

41

O14682
NHQLLNDRVFEERRA

FBXO16

26

Q8IX29
DQHQLLRDNRAERGH

GPATCH2

401

Q9NW75
RERARQRFQQHLEQE

CEP131

771

Q9UPN4
AQGRDAFRHLVHQRR

CFAP74

326

Q9C0B2
TELRQRRQLFEAGLH

JARID2

1091

Q92833
EEKRRNHLQNGHLRF

EPHA6

586

Q9UF33
GRRRDFHDLGVNTRQ

PIWIL1

81

Q96J94
RGLQRQERHLFLFND

ARHGAP20

96

Q9P2F6
LQLRHGNDQRVFRLE

RTF1

426

Q92541
QLLQARADGHFQQRA

SFI1

471

A8K8P3
DQNLRDQIQHRIIGF

SPEF2

826

Q9C093
AQDRAHRIGQQNEVR

SMARCA2

1156

P51531
VNGGELFFHLQRERR

SGK2

116

Q9HBY8
FHRKAQQNRRGFSEE

TAGLN3

151

Q9UI15
LNFLRQRQGHFSRDV

TEC

451

P42680
HFQNRVNLVGDIFRN

JAML

201

Q86YT9
AQDRAHRIGQQNEVR

SMARCA4

1186

P51532
ELRQREGQRFGAAHV

RNF6

266

Q9Y252
GRLDRELQRANSHFI

STX6

141

O43752
NVSAFERRLRAHNRN

TENM1

1781

Q9UKZ4
RRQREHLEGNNKGER

SCN3A

506

Q9NY46
FNHPAEAAVLRQRRQ

STARD9

576

Q9P2P6
HLAGLQFREQEVRNQ

IQCJ-SCHIP1

306

B3KU38
REALSLLQQHREFGR

SPTBN5

1241

Q9NRC6
RLQNYDENGRIHSLR

STON2

486

Q8WXE9
GNFELGELIRNHREQ

SHANK1

391

Q9Y566
QEARGALQNRLRVFL

SRRT

211

Q9BXP5
ERQLHEAARQNNVGR

ANKDD1A

16

Q495B1
LLGYRHVRSEQEQRN

CHST4

356

Q8NCG5
LLDADGFLNVRNHRN

CLSPN

871

Q9HAW4
QRDRRAAGNRHIENQ

ZNF665

126

Q9H7R5
ERALQRLQAREGHRY

SNX20

251

Q7Z614
CLDERQHAQRNVGER

TNIP2

171

Q8NFZ5
LFVQKGRLRDAAQRH

RNF213

4096

Q63HN8
LVVFNNLQLADGRRH

THBS4

111

P35443
LANQKQQHLAFRDRR

TSR1

236

Q2NL82
AAQQFLGRLRDNREQ

SPTBN2

1266

O15020
LGRLRDNREQQHFLQ

SPTBN2

1271

O15020
RGTLRRDFNHINVEL

RPL9

31

P32969
HQLQAERAQGFRRLE

REX1BD

46

Q96EN9
NRAEAQQRRLLGRHE

SPC24

21

Q8NBT2
LIREAGNSFVRHNAR

PLCD3

566

Q8N3E9
RRFLNHLNNRLGDQR

SYCP2L

276

Q5T4T6
LVQLHNNEAGRLAVR

WNT6

201

Q9Y6F9
ERRLQEARALHQFGA

SPTBN4

766

Q9H254
HLRQQRAVEDYGRNI

SPTB

1626

P11277
FSVQALQRRHEGFER

SPTA1

1216

P02549
RALLQVERRFGQIHE

TSPYL6

221

Q8N831
RAFEARDRNLQEGNL

TMED1

176

Q13445
RRFRRQDVRHGNAAQ

SEMA3E

556

O15041
NASRRRNGLHDVDLN

TAPR1

221

Q14CZ0
LLRRLGEHIQQFQES

PRSS16

26

Q9NQE7
GFEIRQLRAHLAQQD

TMEM266

256

Q2M3C6
GNRNVHLEFTERESR

L1TD1

186

Q5T7N2