Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetyl-CoA binding	PANK3 TAF1	3.82e-05	4	51	2	GO:1905502
GeneOntologyMolecularFunction	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	ST3GAL2 ST3GAL3	1.33e-04	7	51	2	GO:0003836
Domain	Homeobox_antennapedia	HOXA4 HOXD4	4.74e-04	12	51	2	IPR017995
Domain	Sialyl_trans	ST3GAL2 ST3GAL3	7.50e-04	15	51	2	IPR012163
Domain	Integrin_alpha_C_CS	ITGA9 ITGAL	8.56e-04	16	51	2	IPR018184
Domain	Integrin_alpha-2	ITGA9 ITGAL	1.09e-03	18	51	2	IPR013649
Domain	Integrin_alpha2	ITGA9 ITGAL	1.09e-03	18	51	2	PF08441
Domain	Integrin_alpha	ITGA9 ITGAL	1.09e-03	18	51	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA9 ITGAL	1.09e-03	18	51	2	PS00242
Domain	Int_alpha_beta-p	ITGA9 ITGAL	1.21e-03	19	51	2	IPR013519
Domain	Int_alpha	ITGA9 ITGAL	1.21e-03	19	51	2	SM00191
Domain	Glyco_trans_29	ST3GAL2 ST3GAL3	1.35e-03	20	51	2	IPR001675
Domain	Glyco_transf_29	ST3GAL2 ST3GAL3	1.35e-03	20	51	2	PF00777
Domain	VWFA	COL12A1 MDN1 ITGAL	1.46e-03	82	51	3	PS50234
Domain	Homeobox_Antennapedia_CS	HOXA4 HOXD4	1.49e-03	21	51	2	IPR001827
Domain	VWA	COL12A1 MDN1 ITGAL	1.56e-03	84	51	3	SM00327
Domain	FG_GAP	ITGA9 ITGAL	1.63e-03	22	51	2	PS51470
Domain	FG-GAP	ITGA9 ITGAL	1.94e-03	24	51	2	PF01839
Domain	FG-GAP	ITGA9 ITGAL	1.94e-03	24	51	2	IPR013517
Domain	ANTENNAPEDIA	HOXA4 HOXD4	1.94e-03	24	51	2	PS00032
Domain	Integrin_dom	ITGA9 ITGAL	2.11e-03	25	51	2	IPR032695
Domain	-	KLHL10 KLHL8	2.46e-03	27	51	2	2.130.10.80
Domain	VWF_A	COL12A1 MDN1 ITGAL	2.50e-03	99	51	3	IPR002035
Domain	Gal_Oxidase_b-propeller	KLHL10 KLHL8	3.88e-03	34	51	2	IPR015916
Domain	BTB	ZBTB7A KLHL10 KLHL8	5.49e-03	131	51	3	PF00651
Domain	BTB-kelch_protein	KLHL10 KLHL8	6.15e-03	43	51	2	IPR017096
Pubmed	Sialylation regulates brain structure and function.	ST3GAL2 ST3GAL3	2.11e-06	2	51	2	25846372
Pubmed	Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.	ST3GAL2 ST3GAL3	2.11e-06	2	51	2	38139047
Pubmed	Salivary Secretory Carcinoma Harboring a Novel ALK Fusion: Expanding the Molecular Characterization of Carcinomas Beyond the ETV6 Gene.	CTNNA1 ALK	6.32e-06	3	51	2	32205481
Pubmed	Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function.	ITGA9 ADAM8	6.32e-06	3	51	2	16995821
Pubmed	Forward spreading in the establishment of a vertebrate Hox expression boundary: the expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers.	HOXA4 HOXD4	1.26e-05	4	51	2	7912569
Pubmed	Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation.	HOXA4 HOXD4	1.26e-05	4	51	2	2576400
Pubmed	Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.	HOXA4 HOXD4	1.26e-05	4	51	2	7628700
Pubmed	Sialyltransferase specificity in selectin ligand formation.	ST3GAL2 ST3GAL3	1.26e-05	4	51	2	12393657
Pubmed	Biosynthesis of the major brain gangliosides GD1a and GT1b.	ST3GAL2 ST3GAL3	1.26e-05	4	51	2	22735313
Pubmed	Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.	ST3GAL2 ST3GAL3	2.10e-05	5	51	2	20395633
Pubmed	Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression.	ST3GAL2 ST3GAL3	2.10e-05	5	51	2	9184827
Pubmed	The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.	HOXA4 HOXD4	2.10e-05	5	51	2	2569969
Pubmed	Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse.	ST3GAL2 ST3GAL3	3.15e-05	6	51	2	10894948
Pubmed	Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease.	ST3GAL2 ST3GAL3	3.15e-05	6	51	2	35452678
Pubmed	Sequence and embryonic expression of the murine Hox-3.5 gene.	HOXA4 HOXD4	4.41e-05	7	51	2	1363091
Pubmed	Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.	HOXA4 HOXD4	4.41e-05	7	51	2	8660891
Pubmed	Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene.	HOXA4 HOXD4	4.41e-05	7	51	2	7680626
Pubmed	Retinoic acid regulates a subset of Cdx1 function in vivo.	HOXA4 HOXD4	5.87e-05	8	51	2	14660544
Pubmed	Hox genes regulate the onset of Tbx5 expression in the forelimb.	HOXA4 HOXD4	5.87e-05	8	51	2	22872086
Pubmed	Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.	HOXA4 HOXD4	7.54e-05	9	51	2	9043087
Pubmed	Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code.	HOXA4 HOXD4	7.54e-05	9	51	2	10579975
Pubmed	Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.	HOXA4 HOXD4	7.54e-05	9	51	2	12242306
Pubmed	Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation.	CTNNA1 PRX	7.54e-05	9	51	2	28692740
Pubmed	Region-specific gastrointestinal Hox code during murine embryonal gut development.	HOXA4 HOXD4	7.54e-05	9	51	2	11869294
Pubmed	Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.	SQSTM1 CTSV	1.15e-04	11	51	2	26682926
Pubmed	A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.	CTNNA1 PRX	1.15e-04	11	51	2	14625392
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	PIKFYVE METAP1 SQSTM1 GBE1 ALK	1.17e-04	327	51	5	15592455
Pubmed	Integrins.	ITGA9 ITGAL	1.38e-04	12	51	2	19693543
Pubmed	Expression of class I homeobox genes in fetal and adult murine skin.	HOXA4 HOXD4	1.38e-04	12	51	2	8105001
Pubmed	The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.	HOXA4 HOXD4	1.63e-04	13	51	2	8887324
Pubmed	Rostral and caudal pharyngeal arches share a common neural crest ground pattern.	HOXA4 HOXD4	1.90e-04	14	51	2	19168678
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	ZBTB7A MDN1 PFKM	2.17e-04	79	51	3	26446488
Pubmed	Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR.	ST3GAL2 ST3GAL3	2.19e-04	15	51	2	10381338
Pubmed	A distinct Hox code for the branchial region of the vertebrate head.	HOXA4 HOXD4	2.19e-04	15	51	2	1682814
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MDN1 SQSTM1 UFD1 GBE1 CTNNA1 PFKM RCC2 PGM3 ITPR2	2.20e-04	1440	51	9	30833792
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	JPH1 SQSTM1 UFD1 GBE1 UHRF1 VPS16	2.48e-04	604	51	6	38803224
Pubmed	Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.	HOXA4 HOXD4	2.50e-04	16	51	2	16624538
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	SQSTM1 UFD1 VPS16 ITPR2	2.68e-04	212	51	4	33853758
Pubmed	Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.	PIKFYVE IL12B	3.55e-04	19	51	2	23322734
Pubmed	The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.	HOXA4 HOXD4	3.94e-04	20	51	2	12370779
Pubmed	Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.	HOXA4 HOXD4	4.35e-04	21	51	2	30254164
Pubmed	Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features.	HOXA4 HOXD4	4.35e-04	21	51	2	25381007
Pubmed	Organization of human class I homeobox genes.	HOXA4 HOXD4	4.78e-04	22	51	2	2576652
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	USP6 SQSTM1 ALDH16A1 VPS16 RCC2	5.11e-04	450	51	5	16751776
Pubmed	Charting the molecular links between driver and susceptibility genes in colorectal cancer.	CTNNA1 PFKM CTSV	5.30e-04	107	51	3	24412244
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	RPS2 SQSTM1 UHRF1 VPS16 PGGT1B	5.31e-04	454	51	5	33226137
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	ZBTB7A SQSTM1 VPS16 PGGT1B RCC2	5.47e-04	457	51	5	32968282
Pubmed	Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.	HOXA4 HOXD4	5.70e-04	24	51	2	9367423
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MDN1 RPS2 SQSTM1 UHRF1 CTNNA1 RCC2 ITPR2	7.03e-04	1024	51	7	24711643
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGA9 ITGAL	7.23e-04	27	51	2	31541017
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	GBE1 PGM3	8.35e-04	29	51	2	32798765
Pubmed	Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.	HOXA4 HOXD4	8.35e-04	29	51	2	33298461
Pubmed	A genetic approach to Mammalian glycan function.	ST3GAL2 ST3GAL3	8.93e-04	30	51	2	12676797
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	METAP1 MDN1 NDUFAF7 UFD1 VPS16	9.36e-04	515	51	5	31617661
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PANK3 SQSTM1 ST3GAL2 ITGA9 PGGT1B LRRC71 NEMP2	9.81e-04	1084	51	7	11544199
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	HOXA4 HOXD4	1.02e-03	32	51	2	37167859
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	MDN1 RPS2 UHRF1 TAF1 VPS16	1.09e-03	533	51	5	30554943
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	USP6 CDC42EP4 UHRF1 KLHL8 MBD5	1.12e-03	536	51	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	USP6 CDC42EP4 UHRF1 KLHL8 MBD5	1.14e-03	538	51	5	10512203
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	GBE1 KLHL8 PFKM PGM3	1.15e-03	313	51	4	20800603
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	RPS2 SQSTM1 ALDH16A1 UFD1 CTNNA1 PFKM PGGT1B RCC2	1.18e-03	1455	51	8	22863883
Pubmed	Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.	CTNNA1 ADAM8	1.22e-03	35	51	2	16452166
Pubmed	RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.	MDN1 UHRF1 RCC2	1.30e-03	146	51	3	21589869
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	SQSTM1 ALDH16A1 VPS16 PFKM PGM3	1.36e-03	560	51	5	35241646
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	ST3GAL2 ST3GAL3	1.36e-03	37	51	2	2541446
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	ST3GAL2 ST3GAL3	1.36e-03	37	51	2	2542563
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	JPH1 PIKFYVE MDN1 RPS2 SQSTM1 NDUFAF7 PFKM ITPR2	1.41e-03	1496	51	8	32877691
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXA4 HOXD4	1.43e-03	38	51	2	15042701
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	ST3GAL2 ST3GAL3	1.43e-03	38	51	2	2829950
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	SLC8A2 ITPR2	1.43e-03	38	51	2	30786075
Pubmed	Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.	CDC42EP4 CTNNA1	1.43e-03	38	51	2	30240734
Pubmed	Identification of 10 murine homeobox genes.	HOXA4 HOXD4	1.43e-03	38	51	2	1683707
Pubmed	Complete mutation analysis panel of the 39 human HOX genes.	HOXA4 HOXD4	1.43e-03	38	51	2	11857506
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	ST3GAL2 ST3GAL3	1.43e-03	38	51	2	2187500
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA9 ITGAL	6.79e-04	18	39	2	1160
GeneFamily	Sialyltransferases	ST3GAL2 ST3GAL3	8.41e-04	20	39	2	438
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB7A KLHL10 KLHL8	2.99e-03	134	39	3	861
GeneFamily	Kelch like\|BTB domain containing	KLHL10 KLHL8	3.70e-03	42	39	2	617
GeneFamily	HOXL subclass homeoboxes	HOXA4 HOXD4	5.62e-03	52	39	2	518
Computational	Neighborhood of RAP1B	VPS16 ITGAL ADAM8	1.76e-04	36	33	3	GNF2_RAP1B
Drug	LFA703	IL12B ITGAL PGGT1B	2.98e-06	13	51	3	CID000449169
Drug	Deltaline [6836-11-9]; Up 200; 7.8uM; HL60; HT_HG-U133A	IL12B CDC42EP4 THSD7A RPS2 CTSV ALK	5.21e-06	198	51	6	2171_UP
Disease	Glycogen storage disease	GBE1 PFKM	3.92e-04	17	51	2	cv:C0017919
Disease	leukemia (implicated_via_orthology)	HOXA4 HOXD4	4.92e-04	19	51	2	DOID:1240 (implicated_via_orthology)
Disease	epiandrosterone sulfate measurement	ZBTB7A ALK	8.57e-04	25	51	2	EFO_0021120
Disease	Glycogen Storage Disease	GBE1 PFKM	1.00e-03	27	51	2	C0017919
Disease	androsterone sulfate measurement	ZBTB7A ALK	1.49e-03	33	51	2	EFO_0021117

Protein segments in the cluster

Peptide	Gene	Start	Entry
IDGVTVLGGQFHDYG	PGM3	141	O95394
QEFDIGVYFEANGHG	PGM3	361	O95394
SGNLHGYVAEGGAKD	ALDH16A1	551	Q8IZ83
LNGGHFYEGPAEAEE	ALX3	81	O95076
DHGVLVVGYGFEGAN	CTSV	276	O60911
YGGLLDEMFNHAGAG	ABCA13	3401	Q86UQ4
GGEGGRHAVYQAEHL	ADAM8	146	P78325
FGGYGRLGHAEQKDE	RCC2	356	Q9P258
YNQGLECDHGDDEGG	ITPR2	2081	Q14571
GEGATEFHDYEGGGI	MDN1	4666	Q9NU22
NGYHGDLNETFFVGE	METAP1	226	P53582
GGFVLNFHADAELAG	JPH1	191	Q9HDC5
GKVYAVGGHDGNEHL	KLHL8	366	Q9P2G9
VHEGYQGLVDGGDHI	PFKM	51	P08237
HEEQYGLGGAFLEEQ	NEMP2	396	A6NFY4
FNHIGDEGAGYIADG	LRRC71	261	Q8N4P6
GKGGGDAHDEEELYF	EPHA10	596	Q5JZY3
EFGDAGQYTCHKGGE	IL12B	81	P29460
GGGALGDAAYFAVEE	DCHS2	346	Q6V1P9
LEHEGYFGAVGALLG	PANK3	351	Q9H999
QAYFAVFDGHGGVDA	PPM1E	266	Q8WY54
EQGADYYGGGAQGAD	HOXD4	31	P09016
DFAGAVYIYHGDAGG	ITGA9	391	Q13797
RGHEGAVQEQYGGGS	PIKFYVE	896	Q9Y2I7
GGEGYLNFMGNEFGH	GBE1	531	Q04446
IAYGEHVYAVGGFDG	KLHL10	476	Q6JEL2
DASQHQGGGGGELAY	CTNNA1	266	P35221
IAVYEDGDGGHLTGN	COL12A1	2096	Q99715
YGHGDHLIDQGLDVG	GALNT5	761	Q7Z7M9
EGGYHGDEGAAGTIT	CDC42EP4	236	Q9H3Q1
DHGKNVNEGDGFEYF	MBD5	1171	Q9P267
EEYAQHSGSGGADGG	HOXA4	21	Q00056
GDGEAEGDQRAGGYY	ARHGAP30	841	Q7Z6I6
YDNGLAQGAGLESHG	PGGT1B	206	P53609
DGGQAGIHECLQYAG	THSD7A	876	Q9UPZ6
LTGGAALVADYGHDG	NDUFAF7	291	Q7L592
SYEGDGGEASHGLED	TAF1	1781	P21675
AAAAGVLYGGDDAQG	MEX3C	181	Q5U5Q3
LRGSGYGQDVDGHNF	ST3GAL2	161	Q16842
LHGCDEVAVAGFGYD	ST3GAL3	311	Q11203
EEQGAVYIFNGRHGG	ITGAL	546	P20701
GGFQAHYRDEDGDLV	SQSTM1	61	Q13501
GLGHGAFGEVYEGQV	ALK	1121	Q9UM73
GNHAEYQVAEGEGEA	PRX	1286	Q9BXM0
QEDGAVLVYGLHGDF	VPS16	101	Q9H269
VLAGGYEDDVDHGNF	UHRF1	461	Q96T88
EGEADHSGYAGELGF	UFD1	211	Q92890
AFVAIGDYNGHVGLG	RPS2	126	P15880
AEQGYAHGFDVGCAS	TTC22	151	Q5TAA0
LANGFLYEHEACGNG	USP6	1266	P35125
ATQNGHYGRGGEEEA	ZBTB7A	266	O95365
ARGGGVHYEDACGEL	SLC8A2	566	Q9UPR5