Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein phosphatase binding	HSP90B1 PSG3 PSG8 SIRPB1 SIRPA PTPRT	8.01e-05	210	68	6	GO:0019903
GeneOntologyBiologicalProcess	negative regulation of platelet aggregation	PSG3 PRKCD PSG8	5.06e-05	23	65	3	GO:0090331
GeneOntologyBiologicalProcess	negative regulation of I-kappaB phosphorylation	SIRPB1 SIRPA	5.84e-05	4	65	2	GO:1903720
GeneOntologyBiologicalProcess	negative regulation of nitric oxide biosynthetic process	RGN SIRPB1 SIRPA	6.54e-05	25	65	3	GO:0045019
GeneOntologyBiologicalProcess	negative regulation of nitric oxide metabolic process	RGN SIRPB1 SIRPA	6.54e-05	25	65	3	GO:1904406
GeneOntologyBiologicalProcess	negative regulation of homotypic cell-cell adhesion	PSG3 PRKCD PSG8	9.25e-05	28	65	3	GO:0034111
GeneOntologyBiologicalProcess	negative regulation of macrophage inflammatory protein 1 alpha production	SIRPB1 SIRPA	9.72e-05	5	65	2	GO:0071641
GeneOntologyBiologicalProcess	negative regulation of platelet activation	PSG3 PRKCD PSG8	1.26e-04	31	65	3	GO:0010544
GeneOntologyBiologicalProcess	cellular response to hydrogen peroxide	TRPM2 PRKCD SIRPB1 SIRPA	1.31e-04	82	65	4	GO:0070301
GeneOntologyBiologicalProcess	negative regulation of protein phosphorylation	RGN PSG3 PRKCD PSG8 SIRPB1 SIRPA PTPRT	1.75e-04	375	65	7	GO:0001933
GeneOntologyBiologicalProcess	insulin metabolic process	HSP90B1 PSG3 PSG8	1.82e-04	35	65	3	GO:1901142
GeneOntologyBiologicalProcess	platelet aggregation	PSG3 PRKCD PSG8 UBASH3A	2.31e-04	95	65	4	GO:0070527
GeneOntologyBiologicalProcess	negative regulation of phosphorylation	RGN PSG3 PRKCD PSG8 SIRPB1 SIRPA PTPRT	2.63e-04	401	65	7	GO:0042326
GeneOntologyBiologicalProcess	regulation of macrophage inflammatory protein 1 alpha production	SIRPB1 SIRPA	2.70e-04	8	65	2	GO:0071640
GeneOntologyBiologicalProcess	regulation of platelet aggregation	PSG3 PRKCD PSG8	3.14e-04	42	65	3	GO:0090330
GeneOntologyBiologicalProcess	negative regulation of chemokine (C-C motif) ligand 5 production	SIRPB1 SIRPA	3.47e-04	9	65	2	GO:0071650
GeneOntologyBiologicalProcess	macrophage inflammatory protein-1 alpha production	SIRPB1 SIRPA	3.47e-04	9	65	2	GO:0071608
GeneOntologyBiologicalProcess	regulation of I-kappaB phosphorylation	SIRPB1 SIRPA	4.33e-04	10	65	2	GO:1903719
GeneOntologyBiologicalProcess	dermatan sulfate metabolic process	HEXB DSEL	4.33e-04	10	65	2	GO:0030205
GeneOntologyBiologicalProcess	import into cell	PSG3 CLN3 SLC22A1 TRPM2 PRKCD PSG8 SIRPB1 SIRPA ATP1A4 DNAJC6 CXCR2	4.88e-04	1074	65	11	GO:0098657
GeneOntologyBiologicalProcess	establishment or maintenance of transmembrane electrochemical gradient	SLC22A1 ATP1A4	5.28e-04	11	65	2	GO:0010248
GeneOntologyBiologicalProcess	regulation of homotypic cell-cell adhesion	PSG3 PRKCD PSG8	6.25e-04	53	65	3	GO:0034110
GeneOntologyBiologicalProcess	homotypic cell-cell adhesion	PSG3 PRKCD PSG8 UBASH3A	6.35e-04	124	65	4	GO:0034109
GeneOntologyBiologicalProcess	response to hydrogen peroxide	TRPM2 PRKCD SIRPB1 SIRPA	6.74e-04	126	65	4	GO:0042542
GeneOntologyBiologicalProcess	regulation of fibroblast migration	CLN3 RCC2 WDPCP	7.35e-04	56	65	3	GO:0010762
GeneOntologyBiologicalProcess	cellular response to interleukin-12	SIRPB1 SIRPA	7.46e-04	13	65	2	GO:0071349
GeneOntologyBiologicalProcess	monocyte extravasation	SIRPB1 SIRPA	7.46e-04	13	65	2	GO:0035696
GeneOntologyBiologicalProcess	dermatan sulfate proteoglycan metabolic process	HEXB DSEL	7.46e-04	13	65	2	GO:0050655
GeneOntologyBiologicalProcess	negative regulation of phosphate metabolic process	RGN PSG3 PRKCD PSG8 SIRPB1 SIRPA PTPRT	7.50e-04	478	65	7	GO:0045936
GeneOntologyBiologicalProcess	negative regulation of phosphorus metabolic process	RGN PSG3 PRKCD PSG8 SIRPB1 SIRPA PTPRT	7.68e-04	480	65	7	GO:0010563
GeneOntologyBiologicalProcess	regulation of filopodium assembly	CLN3 TRPM2 PRKCD	7.74e-04	57	65	3	GO:0051489
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	8.03e-05	4	69	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	8.03e-05	4	69	2	PF01557
Domain	STAG	STAG3L4 STAG3	8.03e-05	4	69	2	IPR013721
Domain	-	FAHD2B FAHD2A	8.03e-05	4	69	2	3.90.850.10
Domain	STAG	STAG3L4 STAG3	8.03e-05	4	69	2	PF08514
Domain	WD_REPEATS_2	DMXL2 WDR36 TLE3 DCAF8L2 WDR26 WDPCP	5.74e-04	279	69	6	PS50082
Domain	WD_REPEATS_REGION	DMXL2 WDR36 TLE3 DCAF8L2 WDR26 WDPCP	5.74e-04	279	69	6	PS50294
Domain	WD40_repeat_dom	DMXL2 WDR36 TLE3 DCAF8L2 WDR26 WDPCP	7.95e-04	297	69	6	IPR017986
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH8	1.19e-03	14	69	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH8	1.19e-03	14	69	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH8	1.19e-03	14	69	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH8	1.19e-03	14	69	2	PF08393
Domain	MT	DNAH3 DNAH8	1.19e-03	14	69	2	PF12777
Domain	AAA_8	DNAH3 DNAH8	1.19e-03	14	69	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH8	1.19e-03	14	69	2	IPR011704
Domain	AAA_5	DNAH3 DNAH8	1.19e-03	14	69	2	PF07728
Domain	ConA-like_dom	FAT3 LAMA2 PTPRT RSPRY1 ADGRG6	1.29e-03	219	69	5	IPR013320
Domain	DHC_fam	DNAH3 DNAH8	1.37e-03	15	69	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DNAH8	1.37e-03	15	69	2	IPR004273
Domain	Dynein_heavy	DNAH3 DNAH8	1.37e-03	15	69	2	PF03028
Domain	-	DMXL2 WDR36 TLE3 DCAF8L2 WDR26 WDPCP	1.43e-03	333	69	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DMXL2 WDR36 TLE3 DCAF8L2 WDR26 WDPCP	1.48e-03	335	69	6	IPR015943
Domain	WD40	DMXL2 WDR36 TLE3 DCAF8L2 WDR26	2.69e-03	259	69	5	PF00400
Domain	WD40	DMXL2 WDR36 TLE3 DCAF8L2 WDR26	3.12e-03	268	69	5	SM00320
Domain	WD40_repeat	DMXL2 WDR36 TLE3 DCAF8L2 WDR26	3.32e-03	272	69	5	IPR001680
Domain	WD_REPEATS_1	DMXL2 WDR36 TLE3 WDR26 WDPCP	3.65e-03	278	69	5	PS00678
Domain	IG	PSG3 ALPK3 PSG8 SIRPB1 SIRPA PTPRT	4.59e-03	421	69	6	SM00409
Domain	Ig_sub	PSG3 ALPK3 PSG8 SIRPB1 SIRPA PTPRT	4.59e-03	421	69	6	IPR003599
Domain	V-set	PSG3 PSG8 SIRPB1 SIRPA	4.79e-03	184	69	4	PF07686
Domain	-	FAT3 LAMA2 ADGRG6	5.24e-03	95	69	3	2.60.120.200
Domain	Ig_V-set	PSG3 PSG8 SIRPB1 SIRPA	6.30e-03	199	69	4	IPR013106
Domain	-	HEXB KL	7.40e-03	35	69	2	3.20.20.80
Pubmed	Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.	PRKCD SIRPB1 SIRPA	3.40e-08	4	72	3	19881493
Pubmed	Proteome-wide characterization of N-glycosylation events by diagonal chromatography.	PSG3 A2ML1 PSG8 SIRPB1 SIRPA	5.81e-07	77	72	5	16944957
Pubmed	Activation of CEA-CAM-1-mediated cell adhesion via CD98: involvement of PKCdelta.	PSG3 PRKCD PSG8	3.80e-06	15	72	3	14527684
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	4.23e-06	2	72	2	15774318
Pubmed	Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis.	PSG3 PSG8	4.23e-06	2	72	2	2302228
Pubmed	The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211.	LAMA2 ADGRG6	4.23e-06	2	72	2	25695270
Pubmed	SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.	SIRPB1 SIRPA	1.27e-05	3	72	2	36202053
Pubmed	Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes.	SIRPB1 SIRPA	1.27e-05	3	72	2	15034021
Pubmed	Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.	SIRPB1 SIRPA	1.27e-05	3	72	2	26222253
Pubmed	Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.	SIRPB1 SIRPA	1.27e-05	3	72	2	12167615
Pubmed	Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.	SIRPB1 SIRPA	1.27e-05	3	72	2	31507080
Pubmed	Involvement of signal regulatory protein α, a negative regulator of Toll-like receptor signaling, in impairing the MyD88-independent pathway and intracellular killing of Burkholderia pseudomallei-infected mouse macrophages.	SIRPB1 SIRPA	1.27e-05	3	72	2	22988019
Pubmed	Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.	SIRPB1 SIRPA	1.27e-05	3	72	2	22468987
Pubmed	Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.	SIRPB1 SIRPA	1.27e-05	3	72	2	34917090
Pubmed	Effect of Serum Deprivation Stress on Signal Induction Regulatory Protein-Alpha (SIRP-Alpha)-Mediated Erythrophagocytosis by Macrophages.	SIRPB1 SIRPA	1.27e-05	3	72	2	30894504
Pubmed	Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha.	SIRPB1 SIRPA	1.27e-05	3	72	2	19667119
Pubmed	SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors.	SIRPB1 SIRPA	1.27e-05	3	72	2	28669759
Pubmed	SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).	SIRPB1 SIRPA	1.27e-05	3	72	2	23022485
Pubmed	Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.	SIRPB1 SIRPA	1.27e-05	3	72	2	29158380
Pubmed	Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells.	SIRPB1 SIRPA	1.27e-05	3	72	2	25817792
Pubmed	Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.	SIRPB1 SIRPA	1.27e-05	3	72	2	12134038
Pubmed	Central nervous system antigen P84 can serve as a substrate for neurite outgrowth.	SIRPB1 SIRPA	1.27e-05	3	72	2	2303162
Pubmed	SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.	SIRPB1 SIRPA	1.27e-05	3	72	2	16141346
Pubmed	Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.	SIRPB1 SIRPA	1.27e-05	3	72	2	31883525
Pubmed	Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.	SIRPB1 SIRPA	1.27e-05	3	72	2	23504854
Pubmed	SIRPα signaling regulates podocyte structure and function.	SIRPB1 SIRPA	1.27e-05	3	72	2	23842779
Pubmed	Essential roles of SIRPα in homeostatic regulation of skin dendritic cells.	SIRPB1 SIRPA	1.27e-05	3	72	2	20955735
Pubmed	A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.	SIRPB1 SIRPA	1.27e-05	3	72	2	17825046
Pubmed	SIRPα deficiency accelerates the pathologic process in models of Parkinson disease.	SIRPB1 SIRPA	1.27e-05	3	72	2	31322787
Pubmed	Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.	SIRPB1 SIRPA	1.27e-05	3	72	2	35634325
Pubmed	The Rho kinase pathway regulates the migration of dendritic cells through SIRP-α.	SIRPB1 SIRPA	1.27e-05	3	72	2	22391241
Pubmed	The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family.	SIRPB1 SIRPA	1.27e-05	3	72	2	9348339
Pubmed	Targeting SIRP-α protects from type 2-driven allergic airway inflammation.	SIRPB1 SIRPA	1.27e-05	3	72	2	21108471
Pubmed	Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.	SIRPB1 SIRPA	1.27e-05	3	72	2	16920950
Pubmed	Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation.	SIRPB1 SIRPA	1.27e-05	3	72	2	17109464
Pubmed	Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation.	SIRPB1 SIRPA	1.27e-05	3	72	2	23504624
Pubmed	Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice.	SIRPB1 SIRPA	1.27e-05	3	72	2	23472187
Pubmed	SIRP/CD47 signaling in neurological disorders.	SIRPB1 SIRPA	1.27e-05	3	72	2	25795378
Pubmed	Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.	SIRPB1 SIRPA	1.27e-05	3	72	2	25236797
Pubmed	Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.	SIRPB1 SIRPA	1.27e-05	3	72	2	31370677
Pubmed	A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.	SIRPB1 SIRPA	1.27e-05	3	72	2	30770827
Pubmed	Signal regulatory protein α protects podocytes through promoting autophagic activity.	SIRPB1 SIRPA	1.27e-05	3	72	2	30888336
Pubmed	Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.	SIRPB1 SIRPA	1.27e-05	3	72	2	38758648
Pubmed	Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.	SIRPB1 SIRPA	1.27e-05	3	72	2	33795678
Pubmed	Requirement of SIRPα for protective immunity against Leishmania major.	SIRPB1 SIRPA	1.27e-05	3	72	2	20854790
Pubmed	Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.	SIRPB1 SIRPA	1.27e-05	3	72	2	17617577
Pubmed	BIT, an immune antigen receptor-like molecule in the brain.	SIRPB1 SIRPA	1.27e-05	3	72	2	9271230
Pubmed	Gene structure of mouse BIT/SHPS-1.	SIRPB1 SIRPA	1.27e-05	3	72	2	10585853
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	1.27e-05	3	72	2	38287013
Pubmed	Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.	SIRPB1 SIRPA	1.27e-05	3	72	2	18635660
Pubmed	Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.	SIRPB1 SIRPA	1.27e-05	3	72	2	29914984
Pubmed	SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.	SIRPB1 SIRPA	1.27e-05	3	72	2	11118207
Pubmed	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.	SIRPB1 SIRPA	1.27e-05	3	72	2	34050181
Pubmed	Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.	SIRPB1 SIRPA	1.27e-05	3	72	2	15123722
Pubmed	SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.	SIRPB1 SIRPA	1.27e-05	3	72	2	31099900
Pubmed	Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.	SIRPB1 SIRPA	1.27e-05	3	72	2	33074246
Pubmed	Resistance to collagen-induced arthritis in SHPS-1 mutant mice.	SIRPB1 SIRPA	1.27e-05	3	72	2	18455510
Pubmed	Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.	SIRPB1 SIRPA	1.27e-05	3	72	2	26057870
Pubmed	Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.	SIRPB1 SIRPA	1.27e-05	3	72	2	18809435
Pubmed	Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.	SIRPB1 SIRPA	1.27e-05	3	72	2	19223164
Pubmed	Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages.	SIRPB1 SIRPA	1.27e-05	3	72	2	18233962
Pubmed	Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.	SIRPB1 SIRPA	1.27e-05	3	72	2	23559001
Pubmed	SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.	SIRPB1 SIRPA	1.27e-05	3	72	2	22671569
Pubmed	Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.	SIRPB1 SIRPA	1.27e-05	3	72	2	35511221
Pubmed	Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.	SIRPB1 SIRPA	1.27e-05	3	72	2	17475843
Pubmed	Lysosome-related genes are regulated in the orbital fat of patients with graves' ophthalmopathy.	HEXB CLN3	1.27e-05	3	72	2	18552385
Pubmed	Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice.	SIRPB1 SIRPA	1.27e-05	3	72	2	12742627
Pubmed	Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs.	SIRPB1 SIRPA	1.27e-05	3	72	2	25818708
Pubmed	SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.	SIRPB1 SIRPA	2.53e-05	4	72	2	35722884
Pubmed	Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.	SIRPB1 SIRPA	2.53e-05	4	72	2	22976304
Pubmed	Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.	SIRPB1 SIRPA	2.53e-05	4	72	2	34097709
Pubmed	TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.	SIRPB1 SIRPA	2.53e-05	4	72	2	26907705
Pubmed	Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia.	SIRPB1 SIRPA	2.53e-05	4	72	2	19771158
Pubmed	Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.	SIRPB1 SIRPA	2.53e-05	4	72	2	33028619
Pubmed	Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages.	SIRPB1 SIRPA	2.53e-05	4	72	2	26085683
Pubmed	Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.	SIRPB1 SIRPA	2.53e-05	4	72	2	10477552
Pubmed	'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47.	SIRPB1 SIRPA	2.53e-05	4	72	2	24143245
Pubmed	Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.	SIRPB1 SIRPA	2.53e-05	4	72	2	32294445
Pubmed	Polymorphism in the innate immune receptor SIRPα controls CD47 binding and autoimmunity in the nonobese diabetic mouse.	SIRPB1 SIRPA	2.53e-05	4	72	2	25305319
Pubmed	Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes.	SIRPB1 SIRPA	2.53e-05	4	72	2	21401967
Pubmed	Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1.	SIRPB1 SIRPA	2.53e-05	4	72	2	14634079
Pubmed	CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.	SIRPB1 SIRPA	2.53e-05	4	72	2	22042861
Pubmed	Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling.	SIRPB1 SIRPA	2.53e-05	4	72	2	16697668
Pubmed	An essential role for the association of CD47 to SHPS-1 in skeletal remodeling.	SIRPB1 SIRPA	2.53e-05	4	72	2	21638321
Pubmed	Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.	SIRPB1 SIRPA	2.53e-05	4	72	2	38245585
Pubmed	Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.	SIRPB1 SIRPA	2.53e-05	4	72	2	37095207
Pubmed	CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.	SIRPB1 SIRPA	2.53e-05	4	72	2	30308165
Pubmed	High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages.	SIRPB1 SIRPA	2.53e-05	4	72	2	9712903
Pubmed	The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.	SIRPB1 SIRPA	2.53e-05	4	72	2	24269920
Pubmed	Target cell CD47 regulates macrophage activation and erythrophagocytosis.	SIRPB1 SIRPA	2.53e-05	4	72	2	16564725
Pubmed	Signal regulatory protein alpha1 is involved in the inhibitory effect of glucocorticoid receptor on the proliferation of murine macrophage RAW264.7 cell and mouse peritoneal macrophage.	SIRPB1 SIRPA	2.53e-05	4	72	2	18728125
Pubmed	The SIRPα-CD47 immune checkpoint in NK cells.	SIRPB1 SIRPA	2.53e-05	4	72	2	33416832
Pubmed	Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.	SIRPB1 SIRPA	2.53e-05	4	72	2	34197341
Pubmed	Suppressed expression of homotypic multinucleation, extracellular domains of CD172α (SIRP-α) and CD47 (IAP) receptors in TAMs upregulated by Hsp70-peptide complex in Dalton's lymphoma.	SIRPB1 SIRPA	2.53e-05	4	72	2	24684700
Pubmed	Interaction between the integrin Mac-1 and signal regulatory protein α (SIRPα) mediates fusion in heterologous cells.	SIRPB1 SIRPA	2.53e-05	4	72	2	30910815
Pubmed	SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.	SIRPB1 SIRPA	2.53e-05	4	72	2	37844448
Pubmed	Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.	SIRPB1 SIRPA	2.53e-05	4	72	2	22851710
Pubmed	SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.	SIRPB1 SIRPA	2.53e-05	4	72	2	24145514
Pubmed	HSF1 promotes the viability of islet β-cells via upregulating SIRPα expression.	SIRPB1 SIRPA	2.53e-05	4	72	2	32141563
Pubmed	CD47 restricts antiviral function of alveolar macrophages during influenza virus infection.	SIRPB1 SIRPA	2.53e-05	4	72	2	36437873
Cytoband	2p15	USP34 WDPCP	1.10e-03	31	72	2	2p15
Cytoband	Xp11.3	RGN FUNDC1	1.56e-03	37	72	2	Xp11.3
Cytoband	Ensembl 112 genes in cytogenetic band chr2p15	USP34 WDPCP	2.20e-03	44	72	2	chr2p15
Cytoband	19q13.2	PSG3 PSG8 TMEM91	2.23e-03	164	72	3	19q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	DNAH3 CLN3 GPRC5B	2.55e-03	172	72	3	chr16p12
GeneFamily	CD molecules\|V-set domain containing\|C1-set domain containing\|Signal regulatory proteins	SIRPB1 SIRPA	7.16e-05	5	49	2	747
GeneFamily	CD molecules\|V-set domain containing\|Pregnancy specific glycoproteins	PSG3 PSG8	3.90e-04	11	49	2	1315
GeneFamily	WD repeat domain containing	DMXL2 WDR36 TLE3 DCAF8L2 WDR26	6.97e-04	262	49	5	362
GeneFamily	Dyneins, axonemal	DNAH3 DNAH8	9.53e-04	17	49	2	536
GeneFamily	Adenosine receptors\|V-set domain containing	PSG3 PSG8 SIRPB1 SIRPA	9.84e-04	163	49	4	590
GeneFamily	C1-set domain containing	SIRPB1 SIRPA	5.78e-03	42	49	2	591
Coexpression	BROWN_MYELOID_CELL_DEVELOPMENT_UP	HEXB PSG3 A2ML1 TRPM2 PSG8 SIRPB1 SIRPA	1.36e-06	201	72	7	MM1006
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 GPCPD1 SIRPB1 SIRPA ZNF467 WDR26	8.76e-07	200	72	6	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HEXB DMXL2 PRKCD SIRPB1 SIRPA ZNF467	8.76e-07	200	72	6	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 TRPM2 GPCPD1 SIRPA CXCR2	6.36e-06	161	72	5	e227f7b711475624cf80e77f235b1783d88d57b4
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 TRPM2 GPCPD1 SIRPA CXCR2	6.36e-06	161	72	5	8280a029026c272cae9649b27575831b0dd4e242
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KL CASD1 CD163L1 TRPM2 ADGRG6	6.75e-06	163	72	5	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	(0)_Myeloid-(00)_Monocyte-(000)_CD14+_Monocyte\|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)	HEXB GPCPD1 SIRPA ZNF467 TMEM91	7.59e-06	167	72	5	7d9fd6a7a45c2aa0d5f2e3960ca4c97ee8836ba5
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPR180 GINS3 EXO1 LAMA2 DNAJC6	8.04e-06	169	72	5	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HEXB DMXL2 GPCPD1 SIRPB1 SIRPA	1.65e-05	196	72	5	5fe6534af65d43eeacd4b031310242b4f706008b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 TLE3 SIRPB1 SIRPA ZNF467	1.69e-05	197	72	5	280804810041783f1b7704914b62ffefbb0d88f6
ToppCell	COVID-19_Mild-Classical_Monocyte\|COVID-19_Mild / Disease condition and Cell class	DMXL2 TLE3 GPCPD1 SIRPA TMEM91	1.73e-05	198	72	5	30ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 GPCPD1 SIRPB1 SIRPA ZNF467	1.77e-05	199	72	5	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	mild-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 GPCPD1 PRKCD SIRPB1 SIRPA	1.81e-05	200	72	5	934c2efc780318c66d667ca75be0de350361d351
ToppCell	control-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HEXB PRKCD SIRPB1 SIRPA ZNF467	1.81e-05	200	72	5	107a0665fb20247511a430178effd7630a619488
ToppCell	mild-Classical_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 TLE3 GPCPD1 SIRPB1 SIRPA	1.81e-05	200	72	5	c8b80d4e7f70c66cbbdd0665821bcd5db69c7d35
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRKCD SIRPB1 NLRP4 WDPCP	4.17e-05	119	72	4	8eefcf1ace62ad1c90fa5b62ec159c83ec527bf3
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASD1 TRPM2 ZNF518A CXCR2	6.43e-05	133	72	4	f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASD1 TRPM2 ZNF518A CXCR2	6.43e-05	133	72	4	292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGN TRPM2 PTPRT CXCR2	7.63e-05	139	72	4	27dd36f5ef03fa97f0fdb19fbd259cb60e7962b3
ToppCell	facs-Marrow-B-cells-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGN TRPM2 PTPRT CXCR2	7.63e-05	139	72	4	2a54627947f8c6597c041f4785f8a4e52d0edfba
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 EXO1 DNAH8 PTPRT	9.72e-05	148	72	4	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	facs-Lung-Endomucin-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 PRKCD SIRPA CXCR2	1.08e-04	152	72	4	962f5bf632da79bd933193d3edd7d89941a85831
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NEK7 ZNF467 PTPRT TMEM91	1.16e-04	155	72	4	79264ff283e36a059040a5aa9fe7337be694cb52
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Efna5\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RGN SLC25A30 STAG3	1.20e-04	59	72	3	52cf452beca2fc91f131997610228a1b04a7f5df
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Efna5-Inhibitory_Gad1Gad2_Htr3a.Efba5_(Interneuron,__(candidate_CGE-derived_4))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RGN SLC25A30 STAG3	1.20e-04	59	72	3	e85f816cbebe7efe99d368cf5c01e68b39e231ac
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Efna5-Inhibitory_Gad1Gad2_Htr3a.Efba5_(Interneuron,__(candidate_CGE-derived_4))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RGN SLC25A30 STAG3	1.20e-04	59	72	3	18cb0aaa7c0652721b4004a042cbc8ff4328a065
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 PRKCD SIRPA AMER3	1.22e-04	157	72	4	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	facs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l8\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 TRPM2 SIRPA CXCR2	1.22e-04	157	72	4	5098675f64342c41c5ca3551b24962d10c83e64d
ToppCell	droplet-Lung-LUNG-1m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.25e-04	158	72	4	30cceb73cf5e24b692da84d33342fd3b1ad5efe5
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXB DMXL2 EXO1 SIRPA	1.25e-04	158	72	4	f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.25e-04	158	72	4	47793463640f98ee5f680a1ee5786b453355fd57
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 FAT3 DNAH8 PTPRT	1.28e-04	159	72	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 LAMA2 SIRPB1 SIRPA	1.28e-04	159	72	4	fb9a45c1d596226128ce4f1adaebb066766e590a
ToppCell	facs-Lung-18m-Hematologic-myeloid-neutrophil\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 TRPM2 GPCPD1 CXCR2	1.38e-04	162	72	4	ad974426039f4952c59d27167eac24dc6ce63f5e
ToppCell	facs-Lung-18m-Hematologic-myeloid-neutrophil-neutrophil\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 TRPM2 GPCPD1 CXCR2	1.38e-04	162	72	4	4e7e565091bce227d794a36af2e5dfc4a791efad
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA PLAAT5	1.41e-04	163	72	4	04152557aae230e9587fcc16cbabf1247cc5b419
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-3\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	HEXB GINS3 ALPK3 RSPRY1	1.41e-04	163	72	4	0e8d3c98209fc98b86b841d69051cee9e276d837
ToppCell	facs-Lung-Endomucin-24m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA PLAAT5	1.41e-04	163	72	4	0644eb8a66d4e944063125c423de66d2393388b1
ToppCell	droplet-Fat-Gat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.41e-04	163	72	4	3d12a8ca97005308403a3ab136af483ab25f9b0e
ToppCell	droplet-Fat-Mat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA CXCR2	1.44e-04	164	72	4	baf6c40b004433c6b1d0bbbb74f73fcd6ee162ea
ToppCell	droplet-Lung-nan-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.44e-04	164	72	4	0e424a69999eee13d27c4ff4f4ba3df64d3c2bda
ToppCell	droplet-Fat-Gat\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.44e-04	164	72	4	c7ad946829c655038b33748dddd7d68c15489034
ToppCell	droplet-Fat-Gat-18m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.44e-04	164	72	4	3aae702a23fbf1d36a6f18596c23e985581de815
ToppCell	droplet-Lung-nan-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.44e-04	164	72	4	fe9ecdd7a6cbaf910f42654eba75f79bea740a00
ToppCell	droplet-Fat-Mat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA CXCR2	1.44e-04	164	72	4	1fc64b21e97e651f88a92de51536b3753f3e08d6
ToppCell	droplet-Fat-Gat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.48e-04	165	72	4	c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCell	droplet-Fat-Gat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 GPCPD1 ELP1 CXCR2	1.48e-04	165	72	4	af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCell	droplet-Lung-nan-18m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA CXCR2	1.58e-04	168	72	4	da1eee804456d910c17f145a5ce79c74a808a2c2
ToppCell	PND03-Immune-Immune_Myeloid\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXB PRKCD SIRPA CXCR2	1.58e-04	168	72	4	f7b911ed2d9d38bab6609da3c37e157ccf1c867b
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 TRPM2 SIRPA CXCR2	1.62e-04	169	72	4	a5964aef04093b460bbe29d5e2e7389f8fd2d46f
ToppCell	facs-BAT-Fat-18m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 TRPM2 GPCPD1 CXCR2	1.62e-04	169	72	4	d3e6c75e5eda133fb6535cfe6c6a1026641f26ac
ToppCell	myeloid-Monocyte-CD14+_Monocyte\|Monocyte / Lineage, cell class and subclass	TLE3 GPCPD1 SIRPA TMEM91	1.62e-04	169	72	4	7c3144a6599787f28662f5b22b8e45f4a115aeda
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 TRPM2 SIRPA CXCR2	1.62e-04	169	72	4	e0076aa61b4ef3f836f5750005d0469d3982eb6d
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	GINS3 PSG3 DNAJC6 ADGRG6	1.62e-04	169	72	4	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	normal_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	RGN CD163L1 ADARB2 ADGRG6	1.66e-04	170	72	4	d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCell	facs-BAT-Fat-3m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 TRPM2 ELP1 CXCR2	1.66e-04	170	72	4	8fd0a55266066a51266ab616c38c883e2680bcf4
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	RGN LAMA2 ADARB2 ADGRG6	1.69e-04	171	72	4	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	facs-BAT-Fat-18m-Myeloid\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA CXCR2	1.73e-04	172	72	4	8e91831804a120037c71cd4e74af686f3c32d31c
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA CXCR2	1.73e-04	172	72	4	0457ccc18697aaec44b7c30ae157aae8f48d8785
ToppCell	facs-BAT-Fat-18m-Myeloid-myeloid_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPCPD1 PRKCD SIRPA CXCR2	1.73e-04	172	72	4	ea4da9aab7a2ff854df21da01d11c9ed99e41fb4
ToppCell	PND03-Immune\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEXB PRKCD SIRPA CXCR2	1.77e-04	173	72	4	8543304ae72f781da311deca05871098eabc4a19
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SAMD9 NRDC ELP1 CXCR2	1.93e-04	177	72	4	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SAMD9 NRDC ELP1 CXCR2	1.93e-04	177	72	4	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	SAMD9 NRDC ELP1 CXCR2	1.93e-04	177	72	4	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SAMD9 NRDC ELP1 CXCR2	1.93e-04	177	72	4	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SAMD9 NRDC ELP1 CXCR2	1.93e-04	177	72	4	d5aeda113afaa2425874394610344570c9078478
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HEXB ALPK3 SIRPB1 SLC27A3	1.98e-04	178	72	4	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	DMXL2 CD163L1 ALPK3 ADGRG6	2.06e-04	180	72	4	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	Control-Myeloid-Alveolar_macrophages\|Control / group, cell type (main and fine annotations)	HEXB DMXL2 GPCPD1 SIRPA	2.11e-04	181	72	4	8d2102c8c86c59a82610f26f90946b290552e666
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DMXL2 CD163L1 TRPM2 SIRPB1	2.15e-04	182	72	4	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RGN FAT3 SLC22A1 ADGRG6	2.20e-04	183	72	4	f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	HSP90B1 DMXL2 CD163L1 TRPM2	2.29e-04	185	72	4	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	normal-na-Myeloid-conventional_dendritic_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	HEXB PRKCD NLRP4 ADGRG6	2.29e-04	185	72	4	67e881a89a491665b8c612fff084c202c0c79235
ToppCell	droplet-Lung-LUNG-1m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 GPCPD1 PRKCD SIRPA	2.29e-04	185	72	4	53a5218c1e6eb12daccde3d6e02f337e2586d74c
ToppCell	Endoth-Lymph\|World / shred by cell class for parenchyma	CD163L1 SIRPA ZNF467 GPRC5B	2.29e-04	185	72	4	97a6c4cd00684d4085d36ef32f7dbb99563ed357
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RGN LAMA2 ADARB2 ADGRG6	2.43e-04	188	72	4	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	3'_v3-GI_small-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	DMXL2 SIRPB1 SIRPA ZNF467	2.48e-04	189	72	4	74a5e61cd820f2495dde40e766c771a31d8c4e7d
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	RGN LAMA2 ADARB2 ADGRG6	2.48e-04	189	72	4	d7ed96add29f219183c802895fbff519b627f635
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 TLE3 GPCPD1 SIRPA	2.64e-04	192	72	4	f14ee74ac3275601749a23c5efe39c2413a62e1a
ToppCell	mild-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SIRPB1 SIRPA ZNF467 CXCR2	2.64e-04	192	72	4	4cd8f572e067bf5fe22f62fa868d7d332f097a8c
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 TLE3 GPCPD1 SIRPA	2.64e-04	192	72	4	0219093e7921a0db78053aee13ec480b520f5662
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 SIRPB1 SIRPA ZNF467	2.69e-04	193	72	4	d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 NRDC PRKCD SIRPA	2.69e-04	193	72	4	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RGN LAMA2 ADARB2 ADGRG6	2.74e-04	194	72	4	8f19e553f18c313c2a2ff9453884b9484b255d71
ToppCell	Control-Classical_Monocyte\|Control / Disease condition and Cell class	DMXL2 SIRPA ZNF467 TMEM91	2.74e-04	194	72	4	9e33e1b54b4114f9e6981819834bb796ed7192b5
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HEXB DMXL2 GPCPD1 SIRPA	2.74e-04	194	72	4	69cf7c989ac355c459db13f9d4267b55adc3c174
ToppCell	droplet-Lung-LUNG-1m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 GPCPD1 PRKCD SIRPA	2.74e-04	194	72	4	621e0e8fe77ff0be83ea9287ce46e97c47e2b3b9
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RGN LAMA2 ADARB2 ADGRG6	2.74e-04	194	72	4	67fbb81b7d20cb63be27b2a2beea5b5689f8e08c
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 NRDC PRKCD SIRPA	2.74e-04	194	72	4	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CD163L1 TRPM2 ZNF467 ADGRG6	2.74e-04	194	72	4	58046894446cb250814252a23f60fdd59c114d77
ToppCell	Monocytes-Phagocytic_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	DMXL2 SIRPB1 SIRPA SLC27A3	2.74e-04	194	72	4	40dbfdf1d7e6b73d120d8f802f08e573fe9a739e
ToppCell	droplet-Lung-1m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 GPCPD1 PRKCD SIRPA	2.74e-04	194	72	4	d16ab5f0cfe73afe6c551fd3123d14784a082f56
ToppCell	Immune-alveolar_macrophage_(MARCO_positive)\|World / Lineage, Cell type, age group and donor	HEXB DMXL2 GPCPD1 SIRPA	2.80e-04	195	72	4	f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 PRKCD SIRPB1 SIRPA	2.80e-04	195	72	4	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 SIRPB1 SIRPA ZNF467	2.80e-04	195	72	4	0110b976f98561ecd2e20ff6e7e3960a401bb7c2
ToppCell	myeloid-CD14+_Monocyte\|myeloid / Lineage and Cell class	DMXL2 TLE3 GPCPD1 TMEM91	2.80e-04	195	72	4	60fab0c24c827567fb42bbd7eb165bf45178c198
ToppCell	Control-Myeloid\|Control / Disease state, Lineage and Cell class	DMXL2 CD163L1 GPCPD1 SIRPA	2.80e-04	195	72	4	46ce2e403ca5d757e5ba17349b6c7ce5cde1f195
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	HEXB DMXL2 GPCPD1 SIRPA	2.80e-04	195	72	4	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 SIRPB1 SIRPA ZNF467	2.80e-04	195	72	4	050fc59b328391d6e3ce23051764a842dcbb3144
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RGN LAMA2 ADARB2 ADGRG6	2.85e-04	196	72	4	c373465e34e2dd581247962d59e0477aae877079
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RGN LAMA2 ADARB2 ADGRG6	2.85e-04	196	72	4	8b5337ccf74de90e8b89a02ac00671af1de2cfff
Disease	level of tyrosine-protein phosphatase non-receptor type substrate 1 in blood serum	SIRPB1 SIRPA	5.23e-06	2	68	2	OBA_2040362
Disease	signal-regulatory protein beta-1 measurement	SIRPB1 SIRPA	1.86e-04	9	68	2	EFO_0802069
Disease	idiopathic osteonecrosis of the femoral head	SAMD9 GPBP1 DNAJC6	2.39e-04	52	68	3	EFO_1001930
Disease	familial hyperlipidemia (implicated_via_orthology)	RGN KL	3.40e-04	12	68	2	DOID:1168 (implicated_via_orthology)
Disease	Colorectal Carcinoma	DNAH3 KL EXO1 DSEL ADARB2 DNAH8 PTPRT	1.15e-03	702	68	7	C0009402
Disease	non-high density lipoprotein cholesterol measurement	USP34 NRDC PSG3 CD163L1 SLC22A1 GPCPD1 WDPCP	1.26e-03	713	68	7	EFO_0005689
Disease	alpha fetoprotein measurement	USP34 EXO1 ATP1A4	1.61e-03	100	68	3	EFO_0010583
Disease	diet measurement, bilirubin measurement	LAMA2 PTPRT	1.64e-03	26	68	2	EFO_0004570, EFO_0008111
Disease	periodontitis	WDR36 FAT3 LAMA2 PTPRT	1.77e-03	223	68	4	EFO_0000649
Disease	immature platelet count	CLN3 SIRPB1 SIRPA	1.91e-03	106	68	3	EFO_0803544
Disease	colorectal cancer, overall survival	WDR36 C8orf44	2.04e-03	29	68	2	EFO_0000638, MONDO_0005575

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGFLQSSWKGKECLL	AMER3	481	Q8N944
FFKLLQISLWGNKCD	ARMT1	181	Q9H993
KRQKGSLAIFCWSFQ	C8orf44	101	Q96CB5
PICAFWDLNKNKSFG	ADGRG6	801	Q86SQ4
WLTAFVTKCFGQAQK	A2ML1	1036	A8K2U0
SGSLKLWCQFFNILS	ALPK3	1491	Q96L96
QLKCQWLKTGQFFLS	DMXL2	96	Q8TDJ6
GKGNGLTWAEKFQCE	CD163L1	851	Q9NR16
NTKTFSKDWVGINGF	MSANTD2	496	Q6P1R3
KCKGQLLIFGATNWD	RCC2	101	Q9P258
QQLFKAFQKAGLGTW	ADARB2	711	Q9NS39
VIWDTLGNKQFCSFK	MAK16	6	Q9BXY0
FCSVCKDFVWGLNKQ	PRKCD	171	Q05655
GLICDFKFGPWKNST	GPBP1	436	Q86WP2
FWEKSSCQIIQFLKG	DCAF8L2	496	P0C7V8
NKAGVNFSEFTGVWK	PDCD6	76	O75340
NGYNFKSDIWSLGCL	NEK7	211	Q8TDX7
ASKVNGWIFGTFLCK	CXCR2	106	P25025
WTNQNLSFAAFKGKG	DNAH8	1421	Q96JB1
EKALSAFLTCGNWKQ	ELP1	1016	O95163
KSGFFNLQEDNWKGC	LAMA2	501	P24043
NGKQWLLGKTFDTFC	FAHD2A	201	Q96GK7
WIFLGCFLTGLLNKK	NLRP4	496	Q96MN2
CIYAQSLWQAIKKGG	GPR180	186	Q86V85
FQCIAGGKWSQHDKL	PTPRT	211	O14522
TLCGKFKRWKLNGAF	GPRC5B	221	Q9NZH0
NDTFWKEFGTNIKLG	HSP90B1	481	P14625
WKNKYVCQLLFGSGV	WDPCP	121	O95876
QVLKSSGGFVWACKN	IDH2	296	P48735
KAKGLVIFCWGDDTN	GPCPD1	576	Q9NPB8
LDCLLQTWKNEGFFA	SLC25A30	246	Q5SVS4
KKANGNCFWHFGLLL	CASD1	541	Q96PB1
KFFKGLAQAGAWACF	DNAH3	1466	Q8TD57
NGKQWLLGKTFDTFC	FAHD2B	201	Q6P2I3
GWCAGFLFQKVGKLA	FUNDC1	61	Q8IVP5
LKVKGFFLITSCNWT	EEF1AKMT2	181	Q5JPI9
KIVDGKLWFQLDCGS	FAT3	3886	Q8TDW7
GQSGFFASLCWQDQK	DNAJC6	421	O75061
NLGGNKDWCKENFVN	DHX33	571	Q9H6R0
CQKSLDFVLGWFAKP	KL	316	Q9UEF7
KQKQLFIGGEACLWG	HEXB	476	P07686
WKLDLFQSCLNAGFL	SLC22A1	146	O15245
FLDKFILKNGAGNWL	DSEL	346	Q8IZU8
WTINGKFQLSGQKLF	PSG3	366	Q16557
FCAQWSLDNLFLKEG	RSPRY1	291	Q96DX4
KGLNDFQCWEKGQAS	GINS3	181	Q9BRX5
SGLFENCFNAKCWKP	TMEM225B	51	P0DP42
CFKKTPDINSLWQSG	SAMD9	1501	Q5K651
WTINGKFQLSGQKLF	PSG8	366	Q9UQ74
TLKWFKNGNELSDFQ	SIRPA	181	P78324
ATIGTKFCALNWKEQ	RGN	71	Q15493
GLQIKLNELWKNFGF	EXO1	786	Q9UQ84
LKWFKNGNELSDFQT	SIRPB1	181	Q5TFQ8
EWVKFCKQLFGGFSL	ATP1A4	96	Q13733
KNAVGFWLLGLCNNF	CLN3	36	Q13286
LKWFKNGNELSDFQT	SIRPB1	181	O00241
GPSWKKFQGSFCEFV	STAG3	181	Q9UJ98
LKSKFSAGQFWEDCQ	SLC27A3	351	Q5K4L6
FKSWRLQCPFGNNDK	TRPM2	41	O94759
LSWKKFQGSFCEFVG	STAG3L4	41	Q8TBR4
FLRKKCWALALFGGN	NRDC	476	O43847
SENILKAKFNCWFCG	ZNF518A	1441	Q6AHZ1
KQCGKAFSWPSSFQI	ZNF709	171	Q8N972
CGKWFVSTGKDNLLN	TLE3	711	Q04726
GCSWKVNNKLDGTYL	PLAAT5	191	Q96KN8
KNSWSCKFVAAGGLQ	USP34	1481	Q70CQ2
NEVWFCKFSNDGTKL	WDR26	356	Q9H7D7
KGCGKAFKWSSYLNQ	ZNF732	561	B4DXR9
GLSFGWKKNLATHQC	ZNF467	361	Q7Z7K2
GIAAFCLAQKTNKAW	TMEM91	111	Q6ZNR0
KECGRGFNWKGNLLT	ZNF337	631	Q9Y3M9
FGKAWLQQCSTPDGK	UBASH3A	411	P57075
TTGSEGLLKFWNFKN	WDR36	556	Q8NI36