Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	proteolysis involved in protein catabolic process	ASCC2 FBXO11 ZSWIM8 RNF123 KEAP1 OTUD5 RSPRY1 MTM1	6.33e-05	812	36	8	GO:0051603
GeneOntologyBiologicalProcess	protein catabolic process	ASCC2 FBXO11 ZSWIM8 RNF123 KEAP1 ABHD17B OTUD5 RSPRY1 MTM1	9.55e-05	1115	36	9	GO:0030163
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process	ASCC2 FBXO11 ZSWIM8 RNF123 KEAP1 OTUD5 MTM1	1.02e-04	640	36	7	GO:0006511
GeneOntologyBiologicalProcess	modification-dependent protein catabolic process	ASCC2 FBXO11 ZSWIM8 RNF123 KEAP1 OTUD5 MTM1	1.14e-04	651	36	7	GO:0019941
GeneOntologyBiologicalProcess	modification-dependent macromolecule catabolic process	ASCC2 FBXO11 ZSWIM8 RNF123 KEAP1 OTUD5 MTM1	1.19e-04	656	36	7	GO:0043632
GeneOntologyBiologicalProcess	regulation of TOR signaling	OTUD5 MTM1 USP32 DYRK3	1.61e-04	158	36	4	GO:0032006
GeneOntologyBiologicalProcess	TOR signaling	OTUD5 MTM1 USP32 DYRK3	2.71e-04	181	36	4	GO:0031929
Domain	VWFA	CPNE2 VWA8 ITIH1	5.69e-04	82	37	3	PS50234
Domain	VWA	CPNE2 VWA8 ITIH1	6.11e-04	84	37	3	SM00327
Domain	VWF_A	CPNE2 VWA8 ITIH1	9.85e-04	99	37	3	IPR002035
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	ASCC2 HSPG2 RNF123 KEAP1 KHDRBS1 OTUD5 USP32	8.07e-07	481	38	7	28190767
Pubmed	Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.	HSPG2 CPD ITIH1	6.53e-05	71	38	3	12754519
Pubmed	Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.	ARSI RAB3GAP2	1.21e-04	15	38	2	24482476
Pubmed	Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.	PCSK5 HAUS7 RNF123 COQ7 CCDC3	2.51e-04	523	38	5	11256614
Pubmed	Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.	CPNE2 RNF123 KEAP1	4.00e-04	131	38	3	28031328
Pubmed	Functional proteomics mapping of a human signaling pathway.	ASCC2 HSPG2 RNF123 KEAP1 KHDRBS1	4.40e-04	591	38	5	15231748
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CPNE2 SNW1 KHDRBS1 VWA8 OTUD5 USP32	4.57e-04	922	38	6	27609421
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	FBXO11 KEAP1 WDR54 OTUD5 ABTB2 MTM1	4.81e-04	931	38	6	27432908
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	ASCC2 KEAP1 WDR54 OTUD5 RAB3GAP2	4.86e-04	604	38	5	38803224
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	FBXO11 KEAP1 SNW1 HSD11B1L KHDRBS1 OTUD5 RAB3GAP2	5.18e-04	1327	38	7	32694731
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	ZSWIM8 OTUD5 USP32	5.60e-04	147	38	3	29576527
Pubmed	Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment.	KHDRBS1 UQCR10	6.38e-04	34	38	2	15741512
Pubmed	A complex oscillating network of signaling genes underlies the mouse segmentation clock.	HSPG2 MTM1	7.56e-04	37	38	2	17095659
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	ASCC2 HAUS7 CPD VWA8 P3H4	8.62e-04	686	38	5	28380382
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	HSPG2 CPD UQCR10 VWA8 GOLM2 P3H4 RAB3GAP2	8.79e-04	1451	38	7	30550785
Pubmed	F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.	HAS1 PKD1L3	8.83e-04	40	38	2	27197753
Pubmed	Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.	HSPG2 ITIH1	1.07e-03	44	38	2	31273033
Pubmed	The LIFEdb database in 2006.	PCSK5 HAUS7 RNF123 COQ7 CCDC3	1.07e-03	720	38	5	16381901
Pubmed	From ORFeome to biology: a functional genomics pipeline.	PCSK5 HAUS7 RNF123 COQ7 CCDC3	1.08e-03	722	38	5	15489336
Interaction	EDN3 interactions	HSPG2 FBXO11 ABHD17B P3H4 RSPRY1	1.76e-06	108	38	5	int:EDN3
Interaction	RNASE12 interactions	RNF123 GOLM2	1.04e-05	3	38	2	int:RNASE12
Cytoband	16q13	CPNE2 RSPRY1	4.13e-04	36	38	2	16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr16q13	CPNE2 RSPRY1	5.10e-04	40	38	2	chr16q13
GeneFamily	Immunoglobulin like domain containing	HSPG2 NCR1 SEMA4G	2.60e-03	193	26	3	594
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KEAP1 ABTB2	1.58e-02	134	26	2	861
Drug	Buflomedil hydrochloride [35543-24-9]; Down 200; 11.6uM; HL60; HT_HG-U133A	HSPG2 CPD ABHD17B MTM1 DYRK3	1.57e-05	196	37	5	1338_DN
Drug	aspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A_EA	ZSWIM8 CPD VWA8 ABTB2 DYRK3	1.60e-05	197	37	5	1042_UP
Drug	Succinylsulfathiazole [116-43-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	HSPG2 VWA8 SEMA4G RAB3GAP2 MTM1	1.60e-05	197	37	5	4265_DN
Disease	apolipoprotein L1 measurement	CPNE2 PKD1L3	4.03e-04	25	35	2	EFO_0021854
Disease	vascular endothelial growth factor measurement	ATP13A5 VWA8	2.02e-03	56	35	2	EFO_0004762
Disease	wellbeing measurement, alcohol consumption measurement	AREG CCDC3	3.50e-03	74	35	2	EFO_0007869, EFO_0007878

Protein segments in the cluster

Peptide	Gene	Start	Entry
DGKNGFYINGGYESH	ATP13A5	1181	Q4VNC0
YDYDNDGGHDFIGEF	CPNE2	231	Q96FN4
GHYAAGLDLNDTYSG	AREG	21	P15514
DQGYHDVGYHGSDIE	ARSI	56	Q5FYB1
YDDTYDGNQVGANDA	ASCC2	616	Q9H1I8
GANAGVGEELAYHYA	HSD11B1L	36	Q7Z5J1
NDAPGQYGAYFHDDG	HSPG2	4196	P98160
FDQGADAIYDHINEG	UQCR10	36	Q9UDW1
GELYNYGVDHLGEEA	RAB3GAP2	1276	Q9H2M9
GNYGAVEYQLHFEGS	NCR1	51	O76036
HNNGAGLIDGAYTDY	ITIH1	891	P19827
DNYGREHFLYQGECG	PCSK5	956	Q92824
LEHGADGNIQDEYGN	POTEB3	226	A0JP26
YHAGQGGLFYSAEVE	CCDC3	66	Q9BQI4
VGVYFYDNGHGVLED	FBXO11	641	Q86XK2
DHAGEYGANRIYAGQ	COQ7	56	Q99807
YAGVHAENAEDYEGR	C1GALT1C1L	226	P0DN25
AGAEAAEGQFDRYYH	CPD	46	O75976
YFAQHEQGAAAGAAD	HAUS7	236	Q99871
AEAYHLAAGAGAYVG	HAS1	536	Q92839
HNCIYAAGGYDGQDQ	KEAP1	516	Q14145
HGEVQDSYEAYGQDD	KHDRBS1	401	Q07666
NNGGYDDADGAYIHV	DYRK3	186	O43781
VGAGYNSEDEYEAAA	OTUD5	171	Q96G74
QHGSKLADYNGDDGN	GOLM2	371	Q6P4E1
LADYNGDDGNVGEYE	GOLM2	376	Q6P4E1
NHEGYGIGDDEYSCA	RSPRY1	386	Q96DX4
DFLDGDAHYERNGNN	PKD1L3	141	Q7Z443
YNGGSLGHDERADAY	ABTB2	306	Q8N961
GAGHNDVELYGQYLE	ABHD17B	261	Q5VST6
DAQPEHSGNYGCYAE	SEMA4G	621	Q9NTN9
TGGGYESDDAYHNAE	MTM1	291	Q13496
EEGVGDTHNSYAYDG	RNF123	161	Q5XPI4
LAAAYGHALEQYEGE	P3H4	36	Q92791
GFAGGEDEIYNVYDQ	SNW1	421	Q13573
AYYLNAQDGAGGEEE	ZSWIM8	731	A7E2V4
FQYDIVGHSGDGYNI	VWA8	1756	A3KMH1
GFLYEHEACGNGYSN	USP32	1471	Q8NFA0
AAGYGNGQVHLYEAT	WDR54	226	Q9H977