Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	MAML1-RBP-Jkappa- ICN1 complex	MAML1 NOTCH1	8.66e-05	3	113	2	GO:0002193
Domain	Peptidase_M60_dom	TCAF2 TCAF1	3.37e-05	2	109	2	IPR031161
Domain	Peptidase_M60	TCAF2 TCAF1	3.37e-05	2	109	2	PF13402
Domain	M60-like	TCAF2 TCAF1	3.37e-05	2	109	2	SM01276
Domain	PEPTIDASE_M60	TCAF2 TCAF1	3.37e-05	2	109	2	PS51723
Domain	Glyco_hydro_47	MAN1A1 MAN1A2	6.95e-04	7	109	2	PF01532
Domain	ZF_UBR	UBR1 UBR4	6.95e-04	7	109	2	PS51157
Domain	-	MAN1A1 MAN1A2	6.95e-04	7	109	2	1.50.10.50
Domain	zf-UBR	UBR1 UBR4	6.95e-04	7	109	2	PF02207
Domain	Znf_UBR	UBR1 UBR4	6.95e-04	7	109	2	IPR003126
Domain	ZnF_UBR1	UBR1 UBR4	6.95e-04	7	109	2	SM00396
Domain	Glyco_hydro_47	MAN1A1 MAN1A2	9.24e-04	8	109	2	IPR001382
Domain	WD40_repeat_dom	UBR4 WDR18 ARHGEF17 WDR26 TLE2 PRPF19 WDR90	1.79e-03	297	109	7	IPR017986
Domain	Class_I_gatase-like	TCAF2 TCAF1	2.14e-03	12	109	2	IPR029062
Domain	-	SEMA4B WDR18 ARHGEF17 WDR26 TLE2 PRPF19 WDR90	3.39e-03	333	109	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA4B WDR18 ARHGEF17 WDR26 TLE2 PRPF19 WDR90	3.51e-03	335	109	7	IPR015943
Domain	VWA	COL6A1 PARP4 CLCA2	4.28e-03	56	109	3	PF00092
Domain	BRCT	PARP4 TP53BP1	5.41e-03	19	109	2	PF00533
Pubmed	The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.	MAML1 MEF2C NOTCH1	1.37e-07	4	114	3	16510869
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TCAF2 CNKSR1 UBR4 MAML1 PHF6 MUC16 CSMD2 POM121C NGDN PARP4 ARHGAP45 ANKRD52 CDH17	1.88e-07	638	114	13	31182584
Pubmed	Transcriptional mechanisms by the coregulator MAML1.	MAML1 MEF2C NOTCH1	3.41e-07	5	114	3	19751190
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	COL6A1 PIGG TUBGCP2 PLD3 POLA2 WDR26 NGDN FOXRED2 SLC39A6 UNK R3HDM1 PCM1 RBM41	1.23e-06	754	114	13	33060197
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA4B UBR4 MAML1 PIGG MLXIP POM121C TLK1 SSH1 PCNX4 NEK8 USP40 WDR90 DOT1L ARRDC2 NOTCH1	3.42e-06	1105	114	15	35748872
Pubmed	Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling.	MAML1 NOTCH1	1.07e-05	2	114	2	23769842
Pubmed	Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans.	TCAF2 TCAF1	1.07e-05	2	114	2	34433829
Pubmed	Nonleukemic T/B mixed phenotype acute leukemia with PHF6 and NOTCH1 mutations.	PHF6 NOTCH1	1.07e-05	2	114	2	34473233
Pubmed	Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.	DOT1L TP53BP1	1.07e-05	2	114	2	21383990
Pubmed	Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.	MAML1 NOTCH1	1.07e-05	2	114	2	20972443
Pubmed	Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population.	FCRL3 FCRL5	1.07e-05	2	114	2	30771554
Pubmed	Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.	MEF2C NOTCH1	1.07e-05	2	114	2	10082551
Pubmed	Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells.	CDH23 USH2A	1.07e-05	2	114	2	17360538
Pubmed	Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.	SERPINA3 BCHE APOB SERPINA5	1.75e-05	47	114	4	14760718
Pubmed	Human transcription factor protein interaction networks.	ADRM1 RPN1 UBR4 MAML1 PHF6 POM121C MEF2C BRD7 SP9 UNK PRPF19 DOT1L R3HDM1 PCM1 TP53BP1 CPEB1	1.76e-05	1429	114	16	35140242
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ADRM1 RPN1 LYPLAL1 UBR4 PHF6 APOB PIGG PLD3 POLA2 ARHGEF17 NGDN FOXRED2 PRPF19 PCM1 TP53BP1	2.27e-05	1297	114	15	33545068
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SEMA4B ADRM1 OR13C8 UBR4 VPS16 POLA2 CDC45 CENPP TLK1 BRD7 NPAP1 STRA6 R3HDM1 PCM1 CPEB1	2.96e-05	1327	114	15	32694731
Pubmed	Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis.	MAN1A1 MAN1A2	3.19e-05	3	114	2	10915796
Pubmed	A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters.	MAML1 NOTCH1	3.19e-05	3	114	2	11390662
Pubmed	ZBP-89 negatively regulates self-renewal of liver cancer stem cells via suppression of Notch1 signaling pathway.	MAML1 NOTCH1	3.19e-05	3	114	2	31874246
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121C POM121B	3.19e-05	3	114	2	30802453
Pubmed	Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis.	MAML1 NOTCH1	3.19e-05	3	114	2	23078884
Pubmed	Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity.	MAML1 NOTCH1	3.19e-05	3	114	2	23293291
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121C POM121B	3.19e-05	3	114	2	35507432
Pubmed	Conformational locking upon cooperative assembly of notch transcription complexes.	MAML1 NOTCH1	3.19e-05	3	114	2	22325781
Pubmed	Direct inhibition of the NOTCH transcription factor complex.	MAML1 NOTCH1	3.19e-05	3	114	2	19907488
Pubmed	Snail inhibits Notch1 intracellular domain mediated transcriptional activation via competing with MAML1.	MAML1 NOTCH1	3.19e-05	3	114	2	23454378
Pubmed	Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein.	NGDN CPEB1	3.19e-05	3	114	2	16705177
Pubmed	Notch signaling mediates hypoxia-induced tumor cell migration and invasion.	MAML1 NOTCH1	3.19e-05	3	114	2	18427106
Pubmed	Structural investigation of the alpha-1-antichymotrypsin: prostate-specific antigen complex by comparative model building.	SERPINA3 SERPINA5	3.19e-05	3	114	2	8732755
Pubmed	Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals.	MAN1A1 MAN1A2	3.19e-05	3	114	2	8144579
Pubmed	Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.	PHF6 NOTCH1	3.19e-05	3	114	2	21880637
Pubmed	Mutational and energetic studies of Notch 1 transcription complexes.	MAML1 NOTCH1	3.19e-05	3	114	2	18155729
Pubmed	Olfactory Sensory Neurons Control Dendritic Complexity of Mitral Cells via Notch Signaling.	MAML1 NOTCH1	3.19e-05	3	114	2	28027303
Pubmed	Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.	MAML1 NOTCH1	3.19e-05	3	114	2	16530044
Pubmed	Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.	MAML1 NOTCH1	3.19e-05	3	114	2	15187027
Pubmed	Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation.	MAN1A1 MAN1A2	3.19e-05	3	114	2	9592125
Pubmed	Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.	MAML1 NOTCH1	3.19e-05	3	114	2	12644465
Pubmed	Grandparental genotyping enhances exome variant interpretation.	PHF6 NOTCH1	3.19e-05	3	114	2	32027463
Pubmed	p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1.	MAML1 NOTCH1	3.19e-05	3	114	2	26033683
Pubmed	Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line.	MAML1 NOTCH1	3.19e-05	3	114	2	11997524
Pubmed	The notch regulator MAML1 interacts with p53 and functions as a coactivator.	MAML1 NOTCH1	3.19e-05	3	114	2	17317671
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA4B TCAF1 POM121C PARP4 TLK1 VPS13D SSH1 POM121B UNC80	3.74e-05	493	114	9	15368895
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	PKD1L2 CSMD2 ABCA5 WDR90	5.62e-05	63	114	4	11572484
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	COL6A1 TUBGCP2 PLD3 POLA2 NGDN FOXRED2 RBM41	5.95e-05	298	114	7	32353859
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TCAF1 RPN1 UBR4 TUBGCP2 CDC45 PRPF19 PCM1	6.20e-05	300	114	7	28561026
Pubmed	Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.	MAML1 NOTCH1	6.36e-05	4	114	2	20118921
Pubmed	A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis.	SERPINA3 SERPINA5	6.36e-05	4	114	2	11161981
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR4	6.36e-05	4	114	2	16055722
Pubmed	TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.	TCAF2 TCAF1	6.36e-05	4	114	2	25559186
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR4	6.36e-05	4	114	2	19008229
Pubmed	Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.	POM121C POM121B	6.36e-05	4	114	2	17900573
Pubmed	Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.	LRRC4 BRD7	6.36e-05	4	114	2	24404152
Pubmed	Coexistence of EZH2, NOTCH1, IL7R, and PHF6 Mutations in Adult T-cell Acute Lymphoblastic Leukemia.	PHF6 NOTCH1	6.36e-05	4	114	2	28747286
Pubmed	Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1.	SERPINA3 SERPINA5	6.36e-05	4	114	2	10209959
Pubmed	Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.	MAML1 NOTCH1	6.36e-05	4	114	2	21266778
Pubmed	p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.	MAML1 NOTCH1	6.36e-05	4	114	2	12391150
Pubmed	Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1.	MAML1 NOTCH1	6.36e-05	4	114	2	22100894
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	SEMA4B MXRA8 CDH23 PIGG LRRC4 MAMDC4 CDC45 SLIT3 CYP4X1 FCRL5 STRA6 ANKRD52	9.74e-05	985	114	12	12975309
Pubmed	Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.	FCRL3 FCRL5	1.06e-04	5	114	2	18704934
Pubmed	Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.	MAML1 NOTCH1	1.06e-04	5	114	2	21124806
Pubmed	Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity.	MAML1 NOTCH1	1.06e-04	5	114	2	26108681
Pubmed	The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase.	MAML1 NOTCH1	1.06e-04	5	114	2	21820430
Pubmed	Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis.	CYP26A1 STRA6	1.06e-04	5	114	2	18093970
Pubmed	Identification of a family of Fc receptor homologs with preferential B cell expression.	FCRL3 FCRL5	1.06e-04	5	114	2	11493702
Pubmed	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.	MAML1 NOTCH1	1.06e-04	5	114	2	11101851
Pubmed	A luminal flavoprotein in endoplasmic reticulum-associated degradation.	RPN1 FOXRED2	1.06e-04	5	114	2	19706418
Pubmed	Deubiquitinase USP10 regulates Notch signaling in the endothelium.	MAML1 NOTCH1	1.06e-04	5	114	2	30975888
Pubmed	Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.	CDH17 CDH18	1.06e-04	5	114	2	10191097
Pubmed	Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia.	FCRL3 FCRL5	1.06e-04	5	114	2	16849395
Pubmed	IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.	FCRL3 FCRL5	1.06e-04	5	114	2	11929751
Pubmed	Defining the membrane proteome of NK cells.	KDM3A MAN1A1 CARMIL2 RPN1 UBR4 PIGG TUBGCP2 PARP4 MAN1A2 PRPF19 ARHGAP45 LMBRD1 PCM1	1.22e-04	1168	114	13	19946888
Pubmed	Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.	MAML1 NOTCH1	1.58e-04	6	114	2	35821235
Pubmed	The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.	KIZ TUBGCP2	1.58e-04	6	114	2	16980960
Pubmed	Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.	MAML1 NOTCH1	1.58e-04	6	114	2	19838210
Pubmed	Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.	MAML1 NOTCH1	1.58e-04	6	114	2	15019995
Pubmed	TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.	MAML1 NOTCH1	1.58e-04	6	114	2	28174252
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	UBR4 VPS16 TUBGCP2 MEF2C FAM120C UNK PCM1 TP53BP1	1.78e-04	475	114	8	31040226
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	SERPINA3 SEMA4B APCS BCHE APOB SERPINA5	2.10e-04	257	114	6	16335952
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	COL6A1 RPN1 BCHE PLD3 ERAP2	2.13e-04	164	114	5	32409323
Pubmed	The human plasma proteome: a nonredundant list developed by combination of four separate sources.	SERPINA3 APCS BCHE APOB SERPINA5	2.19e-04	165	114	5	14718574
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	CDH23 USH2A	2.21e-04	7	114	2	20058854
Pubmed	Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.	NGDN CPEB1	2.21e-04	7	114	2	22727665
Pubmed	The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.	UBR1 UBR4	2.21e-04	7	114	2	34893540
Pubmed	SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.	MAML1 NOTCH1	2.21e-04	7	114	2	11585921
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	UBR4 MUC16 TUBGCP2 NCKAP5L NEK8	2.51e-04	170	114	5	23314748
Pubmed	Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation.	MAN1A1 MAN1A2	2.94e-04	8	114	2	17121831
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	CDH23 USH2A	2.94e-04	8	114	2	19683999
Pubmed	UMD-USHbases: a comprehensive set of databases to record and analyse pathogenic mutations and unclassified variants in seven Usher syndrome causing genes.	CDH23 USH2A	2.94e-04	8	114	2	18484607
Pubmed	Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.	CDH23 USH2A	2.94e-04	8	114	2	16545802
Pubmed	Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.	MAML1 NOTCH1	3.78e-04	9	114	2	12370315
Pubmed	Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.	MAML1 NOTCH1	3.78e-04	9	114	2	17573339
Pubmed	The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis.	MAML1 NOTCH1	3.78e-04	9	114	2	21098559
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR1 UBR4	3.78e-04	9	114	2	17855541
Pubmed	The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.	CYP26A1 STRA6	3.78e-04	9	114	2	24733397
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PHF6 CDH23 DOT1L UNC80	4.36e-04	107	114	4	11347906
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	CDH23 USH2A	4.71e-04	10	114	2	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	CDH23 USH2A	4.71e-04	10	114	2	24239741
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	KDM3A TCAF1 MYO1A ADRM1 RPN1 WDR18 TUBGCP2 POLA2 WDR26 ANKRD52 TP53BP1	4.77e-04	1005	114	11	19615732
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	RPN1 MUC16 GMPR2 MLXIP POM121C CLCA2 UNC80 PCM1	4.84e-04	552	114	8	10737800
Cytoband	19p13.3	TBXA2R WDR18 TLE2 DOT1L ARHGAP45	3.27e-04	237	114	5	19p13.3
Cytoband	14q32.1	SERPINA3 SERPINA5	3.31e-04	11	114	2	14q32.1
GeneFamily	Mannosidases alpha class 1	MAN1A1 MAN1A2	8.82e-05	4	70	2	1193
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR4	3.06e-04	7	70	2	785
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A1 SERPINA3 MXRA8 BCHE PKD1L2 SLIT3 SMTNL2	7.95e-07	198	114	7	7f728ca6d5317890c6fcde3ce6c10c0970d49a05
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	PGGHG MUC16 SYTL3 CYP4X1 TUBA4B CPEB1	3.09e-06	156	114	6	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B MAN1A1 MEF2C TLK1 FCRL5 TEX44	4.74e-06	168	114	6	784ce773521e5d74570f45120e56d112bc76ff49
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KDM3A CNKSR1 PGGHG SPNS2 MXRA8 TP53BP1	4.90e-06	169	114	6	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KDM3A CNKSR1 PGGHG SPNS2 MXRA8 TP53BP1	4.90e-06	169	114	6	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B MAN1A1 MEF2C TLK1 FCRL5 TEX44	5.07e-06	170	114	6	7a4ed69c807c3761210776e8fe6680d1bd892e82
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ARHGEF17 NCKAP5L MEF2C WDR90 DOT1L	8.22e-06	185	114	6	38486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOM1 ARHGEF17 NCKAP5L MEF2C WDR90 DOT1L	8.22e-06	185	114	6	3c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A1 LYPLAL1 KIZ MXRA8 ARHGEF17 PLAG1	8.48e-06	186	114	6	827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	UBR1 PHF6 PARP4 VPS13D RBM41 CDH17	8.48e-06	186	114	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 BCHE SLIT3 SMTNL2	1.02e-05	192	114	6	859a32c9e4ed6961897b2ccaecde73a599471df9
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 BCHE SLIT3 SMTNL2	1.02e-05	192	114	6	89e1da82fa2069dac7adb9cba3e8b6c0179e0dc5
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 SEMA4B MAN1A1 RPN1 MEF2C MAN1A2	1.05e-05	193	114	6	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 MXRA8 BCHE SLIT3 GREB1 SERPINA5	1.08e-05	194	114	6	35b30bc954750e939f81a9a7498b8bc2ce69a299
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MEF2C MAN1A2 ABCA5 R3HDM1 UNC80 CDH18	1.14e-05	196	114	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXA2R MXRA8 ARHGEF17 CDC45 CYP4X1 STRA6	1.14e-05	196	114	6	cb5860f580b477bfa52b22cdc21b808e1371e6e0
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXA2R COL6A1 MXRA8 ARHGEF17 SLIT3 STRA6	1.14e-05	196	114	6	73f029d2b276776d6c24356b14c6592c9cb74bd5
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOM1 BCHE ARHGEF17 MEF2C SLIT3 CYP4X1	1.18e-05	197	114	6	1c91e3afcc5be195b827a1dff83aff5cc2492456
ToppCell	distal-1-mesenchymal-Alveolar_Fibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A1 SERPINA3 MXRA8 BCHE PKD1L2 SMTNL2	1.21e-05	198	114	6	6594c35ab203dc51462167c61807b0d49fa30fb2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 SLIT3 SERPINA5 SMTNL2	1.25e-05	199	114	6	66b4ff23b2e83fb7e6a37fdafdef315cfa33d327
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Fibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	COL6A1 SERPINA3 MXRA8 BCHE SLIT3 SERPINA5	1.28e-05	200	114	6	8d75ce89393df452defacf2ec9a5bd4b7708afbb
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	MEF2C MAN1A2 ABCA5 R3HDM1 UNC80 CDH18	1.28e-05	200	114	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Biopsy_IPF-Mesenchymal-Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	COL6A1 SERPINA3 MXRA8 BCHE SLIT3 SERPINA5	1.28e-05	200	114	6	d8637f1e62d3fb9476dc51e1b1dc2f4b14b5fcd8
ToppCell	Biopsy_Control_(H.)-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	COL6A1 SERPINA3 MXRA8 BCHE SLIT3 SMTNL2	1.28e-05	200	114	6	cdaf462b1db29dab61038eeab5ddd3eef3386763
ToppCell	control-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CSMD2 MEF2C PLAG1 FCRL5 UNC80	1.97e-05	128	114	5	24abab941b4a2f89e13089d208d40ec02f0cad10
ToppCell	TCGA-Bile_Duct\|World / Sample_Type by Project: Shred V9	SERPINA3 APCS APOB SLC25A47 ARRDC2	3.04e-05	140	114	5	ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RA TMEM217 MEF2C CLCA2 NOTCH1	4.94e-05	155	114	5	0e24e767a3895d31d34cabeaca0354aadae34e44
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL10RA TMEM217 MEF2C CLCA2 NOTCH1	4.94e-05	155	114	5	f3489a548a2c0cc2d9117ff85865c6089ea0835d
ToppCell	-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	SERPINA3 CYP26A1 BCHE GREB1 FCRL5	5.09e-05	156	114	5	f0c4d9d58365b0ae8e10ba1aaf3847fb3f98c7ad
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXA2R IL10RA FCRL5 ARHGAP45 CDH17	5.57e-05	159	114	5	656aa20706bdba81bbcc3e68e6058215b92b8802
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SERPINA3 MYOM1 SHC3 ABCA5 SERPINA5	5.74e-05	160	114	5	8bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SERPINA3 MYOM1 SHC3 ABCA5 SERPINA5	5.74e-05	160	114	5	2d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCell	mild_COVID-19_(asymptomatic)-B_cell\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TBXA2R DNAJB7 CENPP NEK8 PLAG1	6.45e-05	164	114	5	e4d43af7eb04d55328791b554bdf3a7ce6818027
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B DNAJB7 MEF2C FCRL5 ARHGAP45	7.86e-05	171	114	5	a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B DNAJB7 MEF2C FCRL5 ARHGAP45	7.86e-05	171	114	5	43d8fd9b9546e84a652564fe96b514b34b06262b
ToppCell	Immune_cells-B_cell\|Immune_cells / Lineage and Cell class	MAN1A1 MYOM1 MEF2C FCRL5 LMBRD1	8.08e-05	172	114	5	b646894b691a99bf2742bd9da8e578dff0e87f1f
ToppCell	droplet-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1A1 CARMIL2 MEF2C FCRL5 ARHGAP45	8.30e-05	173	114	5	886ac1b98f709ad7131df778b83712bf8ed313de
ToppCell	nucseq-Epithelial-Epithelial_Glandular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1A SPNS2 MUC16 CLCA2 CDH17	9.75e-05	179	114	5	859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCDC190 LRRC4 WDR90 TUBA4B PCM1	1.00e-04	180	114	5	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	Ciliated_cells-A-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	CCDC190 MUC16 LRRC4 WDR90 TUBA4B	1.00e-04	180	114	5	d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1A SPNS2 MUC16 CLCA2 CDH17	1.00e-04	180	114	5	3dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO1A SPNS2 MUC16 CLCA2 CDH17	1.00e-04	180	114	5	668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MEF2C FCRL3 ERAP2 FCRL5 ARHGAP45	1.00e-04	180	114	5	65c069585737302a69b9a01476f4eb8b50cb2bfd
ToppCell	control-Lymphoid-B_cell\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MEF2C FCRL3 FCRL5 ARHGAP45 CDH17	1.03e-04	181	114	5	e414303bb90e5fe7b667c2acf9a50f8694b90e54
ToppCell	NS-control-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MEF2C FCRL3 FCRL5 ARHGAP45 CDH17	1.05e-04	182	114	5	4b9b55154a79992112c1c467e8752c3cdbb541d9
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYOM1 MEF2C CLCA2 SLIT3 CDH18	1.08e-04	183	114	5	4060d979948e1dd7507977629a7fbdfa4ca65bb6
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A1 MAN1A1 SHC3 ABCA5 SERPINA5	1.08e-04	183	114	5	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBXA2R MYOM1 MEF2C CLCA2 SLIT3	1.08e-04	183	114	5	b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYOM1 MEF2C CLCA2 SLIT3 CDH18	1.08e-04	183	114	5	0d44a978221cf3f733704bf11863502805fba733
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TCAF1 TLE2 BRD7 NOTCH1 UNC80	1.17e-04	186	114	5	10565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 SLIT3 GREB1	1.17e-04	186	114	5	07d94d5d1c2fe7bb909a07ca81058a0eabc65c60
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEK6 MEF2C FCRL3 FCRL5 ARHGAP45	1.20e-04	187	114	5	8fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEK6 MEF2C FCRL3 FCRL5 ARHGAP45	1.20e-04	187	114	5	edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A1 TCAF1 BCHE GREB1 UNC80	1.20e-04	187	114	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 SLIT3 GREB1	1.23e-04	188	114	5	e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOM1 BCHE MEF2C SLIT3 CYP4X1	1.23e-04	188	114	5	c2321a3a1d9603f8b4b4fc09707eb32ec1e04f3f
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 SLIT3 GREB1	1.26e-04	189	114	5	d531399749409d614adca13d181830c6e3287508
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_memory-B_memory-3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SEMA4B NEK6 LYPLAL1 MEF2C FCRL5	1.26e-04	189	114	5	ac0203f17b481d608587113ea2de0f383b29ed27
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CYP26A1 DNAJB7 STRA6 ARHGAP45	1.27e-04	100	114	4	b4e8f3cbb5023d2227f43e683967ec2f848648f1
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CNKSR1 MAN1A1 RPN1 MEF2C FCRL5	1.29e-04	190	114	5	84eb7761f537d270673909a71d4f122e826769d5
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TBXA2R MYOM1 MEF2C CLCA2 SLIT3	1.32e-04	191	114	5	9431ffd6b758f756609d9057de2023596e22b5d4
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_memory\|lymph-node_spleen / Manually curated celltypes from each tissue	SEMA4B NEK6 MEF2C FCRL3 FCRL5	1.32e-04	191	114	5	c3ca8077da8594fb493e47ac4dfbbd20bfc14b37
ToppCell	PBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CNKSR1 MAN1A1 RPN1 MEF2C FCRL5	1.32e-04	191	114	5	dd1d38a531a272a746c16807688013d29cab823a
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A1 TCAF1 BCHE GREB1 UNC80	1.35e-04	192	114	5	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	COL6A1 MXRA8 SLIT3 GREB1 CPEB1	1.35e-04	192	114	5	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 SEMA4B MAN1A1 RPN1 MAN1A2	1.39e-04	193	114	5	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	TBXA2R PGGHG MXRA8 MLXIP PLAG1	1.39e-04	193	114	5	627d345baf1940218c61907305705298e473dbab
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 SEMA4B MAN1A1 RPN1 MAN1A2	1.39e-04	193	114	5	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	PHF6 MEF2C FCRL3 FCRL5 R3HDM1	1.39e-04	193	114	5	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A1 SEMA4B MAN1A1 RPN1 MAN1A2	1.39e-04	193	114	5	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	metastatic_Brain-Fibroblasts-Pericytes\|metastatic_Brain / Location, Cell class and cell subclass	TBXA2R COL6A1 MXRA8 ARHGEF17 SLIT3	1.42e-04	194	114	5	d1889a3e22d5b88461c81ec3ea0e74bb9bf63e60
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXA2R MXRA8 ARHGEF17 SLIT3 STRA6	1.42e-04	194	114	5	a7731378f44ca1a229311686caf5740c742d21ba
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SEMA4B MEF2C FCRL3 NEK8 FCRL5	1.45e-04	195	114	5	9355dd84350f98cb33466acdfd90a39c50c9e39f
ToppCell	IPF-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	COL6A1 SERPINA3 MXRA8 SLIT3 GREB1	1.45e-04	195	114	5	9c32756edb54f0c211185d9a98073fe01fd1526a
ToppCell	severe-Lymphocytic-Plasmablast\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CNKSR1 MAN1A1 RPN1 MEF2C FCRL5	1.45e-04	195	114	5	43ff1eed563c647bc5b7b06ffe136210653c3a83
ToppCell	MS-plasma-\|MS / Condition, Cell_class and T cell subcluster	CNKSR1 MAN1A1 RPN1 MEF2C FCRL5	1.45e-04	195	114	5	b0a51dea06899e6a4477c3436c85e114cd8f6214
ToppCell	MS-plasma\|MS / Condition, Cell_class and T cell subcluster	CNKSR1 MAN1A1 RPN1 MEF2C FCRL5	1.45e-04	195	114	5	de866c0eaec36d94a3101eb9f949ca9544207f33
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXA2R COL6A1 MXRA8 ARHGEF17 STRA6	1.49e-04	196	114	5	40e6900a0d56088a40d37ec312f53207ea952602
ToppCell	IPF-Stromal-Fibroblast\|IPF / Disease state, Lineage and Cell class	COL6A1 SERPINA3 MXRA8 SLIT3 GREB1	1.49e-04	196	114	5	f7ae604ba32b322d86d68b2b54892e7c6ab06c49
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL6A1 MXRA8 ARHGEF17 CYP4X1 STRA6	1.49e-04	196	114	5	7acd782a587b7d331517f60daa8b5c2177bedfc7
ToppCell	Control-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	COL6A1 SERPINA3 MXRA8 SLIT3 GREB1	1.49e-04	196	114	5	1ec7a4daa51b3156db97e1fd6cb925ad311bb4b5
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCHE ARHGEF17 MEF2C CENPP CYP4X1	1.49e-04	196	114	5	88dc4e3efd7ea07617ecde142ec47cc57608f81b
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXA2R COL6A1 MXRA8 ARHGEF17 STRA6	1.49e-04	196	114	5	0b247cf981981ae61aca5de82ef687e8d783c9ef
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOM1 BCHE MEF2C SLIT3 CYP4X1	1.53e-04	197	114	5	cc494a656db868bb489238a5becc31bc8518f3cc
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL6A1 MXRA8 ARHGEF17 CYP4X1 STRA6	1.53e-04	197	114	5	983502a99e6d59bb36225b0246a9990604de1a01
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCHE ARHGEF17 MEF2C CENPP CYP4X1	1.53e-04	197	114	5	fd65a9b41df618ff2a09d76dcf9f1ca3f3bdf52a
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	CNKSR1 SPNS2 CDC45 MAN1A2 CDH18	1.53e-04	197	114	5	6b6504c47c309bac4f790e2f372d454bbdea49e8
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBXA2R COL6A1 MXRA8 STRA6 SMTNL2	1.53e-04	197	114	5	4a04da876a1482604452ae53c124ae68eda0bd5e
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A1 MYO1A MYOM1 CDH23 BCHE	1.53e-04	197	114	5	ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell	(2)_NK/T-(221)_CD8+_Naive_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	PGGHG MXRA8 MLXIP PLAG1 CPEB1	1.53e-04	197	114	5	5943f30288d4c9a7d7ef2e85461487a229f44511
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MEF2C ABCA5 R3HDM1 UNC80 CDH18	1.56e-04	198	114	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MEF2C ABCA5 R3HDM1 UNC80 CDH18	1.56e-04	198	114	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SERPINA3 MXRA8 BCHE CDH17 SMTNL2	1.56e-04	198	114	5	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A1 SERPINA3 BCHE GREB1 CPEB1	1.56e-04	198	114	5	bfd720e2dae3b6b3dc2bf8b2096c554fd456e756
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MEF2C ABCA5 R3HDM1 UNC80 CDH18	1.56e-04	198	114	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SPNS2 MUC16 FOXRED2 STRA6 UNC80	1.56e-04	198	114	5	1fe60443c11d34b6d2671af8f06e0dedc8d1558b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MEF2C ABCA5 R3HDM1 UNC80 CDH18	1.56e-04	198	114	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	5'-Parenchyma_lung-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 BCHE SLIT3	1.56e-04	198	114	5	aae663c6da70b6e716edeed50cc7d3962d78e697
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Myofibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	COL6A1 SERPINA3 MXRA8 BCHE SLIT3	1.60e-04	199	114	5	7a227c239afdaebcac84644d9b2653a5f1a4be71
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A1 SERPINA3 MXRA8 BCHE SLIT3	1.60e-04	199	114	5	4e128c705ad36fd840582848f278770f356fcc8b
Disease	alpha-1-antichymotrypsin measurement	SERPINA3 SERPINA5	4.35e-05	3	113	2	EFO_0008019
Disease	neurogenic locus notch homolog protein 1 measurement	BCHE NOTCH1	1.44e-04	5	113	2	EFO_0008246
Disease	mediator of RNA polymerase II transcription subunit 1 measurement	SERPINA3 SERPINA5	2.16e-04	6	113	2	EFO_0008228
Disease	plasma serine protease inhibitor measurement	SERPINA3 SERPINA5	2.16e-04	6	113	2	EFO_0020642
Disease	alpha-1-antichymotrypsin complex measurement	SERPINA3 SERPINA5	3.01e-04	7	113	2	EFO_0008018
Disease	Autism Spectrum Disorders	MEF2C SNTG2 USH2A UNC80	3.25e-04	85	113	4	C1510586
Disease	Muscular Dystrophy	COL6A1 BCHE	4.01e-04	8	113	2	C0026850
Disease	kallistatin measurement	SERPINA3 SERPINA5	4.01e-04	8	113	2	EFO_0008196
Disease	tumor necrosis factor receptor superfamily member 19L measurement	BCHE ARHGEF17	4.01e-04	8	113	2	EFO_0008309
Disease	adult respiratory distress syndrome (implicated_via_orthology)	TBXA2R SERPINA3	5.14e-04	9	113	2	DOID:11394 (implicated_via_orthology)
Disease	alpha-1-antitrypsin measurement	SERPINA3 SERPINA5	5.14e-04	9	113	2	EFO_0008327
Disease	cytochrome p450 3a4 measurement	BCHE APOB	7.82e-04	11	113	2	EFO_0020303
Disease	integral membrane protein 2B measurement	BCHE APOB	9.36e-04	12	113	2	EFO_0802634
Disease	low density lipoprotein cholesterol measurement, response to selective serotonin reuptake inhibitor	APCS CSMD2	1.48e-03	15	113	2	EFO_0004611, EFO_0005658
Disease	Hypertriglyceridemia	BCHE APOB	1.48e-03	15	113	2	C0020557
Disease	bilirubin measurement	UBR1 CYP26A1 APOB MLXIP PKD1L2 USP40 UNK	1.60e-03	442	113	7	EFO_0004570
Disease	triglycerides to total lipids in very large HDL percentage	CYP26A1 APOB TP53BP1	1.75e-03	62	113	3	EFO_0022339
Disease	monocyte percentage of leukocytes	NEK6 RPN1 CYP26A1 MAML1 CDH23 WDR26 SHC3 MEF2C ARRDC2	2.03e-03	731	113	9	EFO_0007989
Disease	sodium-coupled monocarboxylate transporter 1 measurement	BCHE APOB	2.38e-03	19	113	2	EFO_0802076
Disease	Malignant neoplasm of breast	KDM3A UBR4 APCS BCHE MAMDC4 FCRL3 CLCA2 SLC39A6 FCRL5 NOTCH1 TP53BP1	2.79e-03	1074	113	11	C0006142
Disease	Colonic Neoplasms	CYP26A1 PARP4 NOTCH1 TP53BP1	2.82e-03	152	113	4	C0009375
Disease	Malignant tumor of colon	CYP26A1 PARP4 NOTCH1 TP53BP1	3.32e-03	159	113	4	C0007102
Disease	Glioblastoma	BCHE NOTCH1 TP53BP1	3.50e-03	79	113	3	C0017636
Disease	cholesterol in large HDL measurement	CYP26A1 APOB TP53BP1	3.63e-03	80	113	3	EFO_0021900

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSGLFSALDSHSNLG	ABCA5	756	Q8WWZ7
SQGSSAAAAGHFLSL	MAMDC4	521	Q6UXC1
TLFGESAGAASVSLH	BCHE	221	P06276
LDGHVSSESSGATFI	CSMD2	3356	Q7Z408
ELSTGSSGHDSSLFE	BRD7	36	Q9NPI1
STALAFLSLGAHNTT	SERPINA3	81	P01011
NAAFDSTLTHLDLSG	CARMIL2	331	Q6F5E8
GLAADLSLHSFSDGA	DOT1L	1321	Q8TEK3
ASGHTDSLHLLIDSG	ANKRD52	661	Q8NB46
HGSTGTLLATDLNSL	CDH23	3286	Q9H251
GHLESELSFLSTLTG	CENPP	61	Q6IPU0
GSRSSSVGSHASFLL	ARRDC2	311	Q8TBH0
TVSTHSSLSFDGGLN	R3HDM1	446	Q15032
HSLVSATSVGDSGTA	RBM41	216	Q96IZ5
SSHGSFTRGSLEDLL	ARHGEF17	1716	Q96PE2
SGLSSVAGHTDLIDS	MAML1	981	Q92585
TGSSSSGVTLGIAHL	MUC16	1636	Q8WXI7
DLSHGVHTSSAGTLA	MUC16	1846	Q8WXI7
GLLAGAHSSLDIASF	PLD3	111	Q8IV08
VSSAASGHLGRSFLS	NOTCH1	2421	P46531
LSSSEASALGHLSFL	ARHGAP45	1041	Q92619
HFTACGSLTRTLDSG	NCKAP5L	1111	Q9HCH0
GLSEFIESTLSGHSL	GREB1	856	Q4ZG55
GLFSLHLSEMSSVGS	MYO1A	951	Q9UBC5
LTDSSFGGTNLHSLR	LRRC53	146	A6NM62
FEELGSSHGLAALSF	LMBRD1	181	Q9NUN5
SSHGLAALSFSISSL	LMBRD1	186	Q9NUN5
LSIGEIFGHGESSSS	CCDC190	271	Q86UF4
SLHSESLEAIFLSSG	C9orf131	201	Q5VYM1
EGVSGASLSSHRSSL	PCM1	631	Q15154
FLSLDSSLQGLHSVS	PCNX4	461	Q63HM2
GEASFNLSLTAEHSG	FCRL5	616	Q96RD9
FLNASIHTGDTFSLS	OR5B3	151	Q8NH48
LGLGRFFSSETTAAH	NEK6	191	Q9HC98
IDLGTAHSAAVTASG	NEK8	566	Q86SG6
DGTLNFSHVLLSDTG	LRRC4	406	Q9HBW1
SSLSGFNTASALHLG	MEF2C	331	Q06413
LGGSTLSLLHDRSFS	TUBGCP2	351	Q9BSJ2
LDLHGSTDSGFGSTK	IL10RA	311	Q13651
LEHLAASSGTGSSDF	GMPR2	96	Q9P2T1
DLATFASTSTLHGLG	ASIC4	41	Q96FT7
ALDTNTGSFLHTLEG	PGGHG	81	Q32M88
GSSLDSSGFSLHIGL	PARP4	821	Q9UKK3
SRGLFILGTASHSVD	FOXRED2	376	Q8IWF2
SHLSGLNIGSGAFET	KIZ	591	Q2M2Z5
LETSALGTFFTHAAL	PKD1L2	2156	Q7Z442
GATHSAFGLKATASA	POM121C	1011	A8CG34
GATHSAFGLKATASA	POM121B	616	A6NF01
GLSLHATGDYLLSSS	PRPF19	311	Q9UMS4
HSSILVTDLGHGTSS	MLXIP	626	Q9HAP2
GSLGHEGLTSFSSLA	DNAJB7	161	Q7Z6W7
FFSLLSGSLNSHGLE	APOB	1611	P04114
GSGTDHFIQALDSLS	CDC45	391	O75419
RFLSLSAADGSDGSH	KDM3A	16	Q9Y4C1
TILLDGSASVGSHNF	COL6A1	831	P12109
FLGNISSASHGLCSS	GAB4	161	Q2WGN9
LGISNVFTSHADLSG	SERPINA5	321	P05154
STFLLAGHDTLAASI	CYP4X1	311	Q8N118
SSLLFSSHALGESHA	FAM120C	466	Q9NX05
SGGGASFNLSLTAEH	FCRL3	431	Q96P31
GGASFNLSLTTEHSG	FCRL3	526	Q96P31
SASLIFLHGSGDSGQ	LYPLAL1	21	Q5VWZ2
SGGSSILAEFGTLHL	MAN1A1	341	P33908
ASAGSSILAEFGTLH	MAN1A2	326	O60476
HAEAFLSSAGLSTGA	CDH18	601	Q13634
FHSLSGFTSSGVKVS	ERAP2	271	Q6P179
ELLFGGHETTASAAT	CYP26A1	296	O43174
FSSGSDHLSDLISSL	CPEB1	191	Q9BZB8
GSHLTSAETFTLDSL	FAM135B	1011	Q49AJ0
LGSFGVVSTHSSTLD	FAM135B	1071	Q49AJ0
EVGGSSLSSVSEFHL	CDH17	641	Q12864
DSTSTEFFLVGLSAH	OR13C8	6	Q8NGS7
STIFSGGFRHGSLIS	SYTL3	276	Q4VX76
FSSSAHGAETVLSEG	USH2A	4771	O75445
AMLSLATGLAHSGSD	TCAF1	491	Q9Y4C2
ATGLAHSGSDLSLLV	TCAF1	496	Q9Y4C2
AVLSLATGLAHSGTD	TCAF2	491	A6NFQ2
LSGSHLFTCGTAAFS	SEMA4B	141	Q9NPR2
AHLGGGSTSRATSFL	RPN1	56	P04843
TSVDDLLHSLSVSGG	SHC3	16	Q92529
LLASSHSASGGESLF	SMCR5	71	Q8TEV8
GSSALVLRDGHSFAT	SLC25A47	181	Q6Q0C1
ALQSFTSHLLGDAGS	SPNS2	461	Q8IVW8
SVSTDGSVLLSGSHD	WDR18	276	Q9BV38
SSGASSPLFDSGLHL	SNTG2	176	Q9NY99
LLFHLGAEEISSSSG	POLA2	476	Q14181
LNTGSISHSTLGATD	NPAP1	891	Q9NZP6
GLGSSAAAASHLLST	SP9	236	P0CG40
SEGHRGLFSGLTATL	SLC25A38	171	Q96DW6
TAGHTAAHLLGSTLS	STRA6	166	Q9BX79
GLSSGLSTSVAVFCH	SLC39A6	621	Q13433
SHSLAKLGSLTFSTE	SSH1	976	Q8WYL5
VFHSLGRGTGSDVTS	TUBA4B	76	Q9H853
ALGASGSSGHELSAL	ADRM1	136	Q16186
SGSTIHSIALGSSAA	CLCA2	436	Q9UQC9
SLTEGLLGATHDFQS	CNKSR1	81	Q969H4
GLGSLHSLSAAFTSS	PLAG1	471	Q6DJT9
GSFNDLTSLSHLALG	SLIT3	841	O75094
ATGFLDSGHSTVADL	TEX44	306	Q53QW1
DSGHSTVADLLHSSG	TEX44	311	Q53QW1
HSFGSLGSLSDKESE	TLK1	96	Q9UKI8
ALVSSHSDNESLGGF	PHF6	51	Q8IWS0
ATSSGHLGFLDTLSR	WDR90	676	Q96KV7
FTGLETSSLLQHGDT	UNC80	3206	Q8N2C7
SLTHFSDISALTGGT	NGDN	271	Q8NEJ9
LTSLLEAFAHTDLSG	APCS	11	P02743
SLVLSHCTGATDGAT	VPS16	811	Q9H269
GDSTLEFHSILSFGV	UBR1	1266	Q8IWV7
ASHATFSLSGRGQSL	SMTNL2	121	Q2TAL5
HSLGAEDTASSQLGF	TP53BP1	156	Q12888
GSHTRSSFLTFLCGL	TBXA2R	56	P21731
SSSSAGDLAHANGLL	WDR26	46	Q9H7D7
RLSISSGFSGSHLES	TMEM217	181	Q8N7C4
LGTAGHVLSLGASSF	PIGG	556	Q5H8A4
GLKDCHVLTFSSSGS	UBR4	1971	Q5T4S7
TFLGTSASHGSLGLN	UNK	601	Q9C0B0
TSFSLGSHSTLNGDL	TLE2	351	Q04725
LFSALETSLVGTSGH	USP40	141	Q9NVE5
GSIGSLSLSDLTCHG	VPS13D	1916	Q5THJ4
LLHSGSSVPAAAGSS	MXRA8	21	Q9BRK3
DYGSSHGLTDSSLLL	MYOM1	91	P52179