Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal aortic sinus morphology

THSD4 FBN1

2.47e-052702MP:0010482
DomainGphrmn_rcpt_fam

TSHR LHCGR LGR6

2.69e-066973IPR002131
DomainASX_HYDROXYL

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

1.35e-05100976PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

1.88e-05106976IPR000152
DomainTIL_dom

LRP2 MUC5AC MUC6

4.74e-0514973IPR002919
DomainEGF_Ca-bd_CS

ADGRL4 FAT1 FBN1 NCAN LRP2

1.50e-0497975IPR018097
DomainEGF_CA

ADGRL4 FAT1 FBN1 NCAN LRP2

1.66e-0499975PS01187
DomainEGF_CA

ADGRL4 FAT1 FBN1 NCAN LRP2

4.37e-04122975SM00179
DomainEGF-like_Ca-bd_dom

ADGRL4 FAT1 FBN1 NCAN LRP2

4.71e-04124975IPR001881
DomainGPS

PKD1L3 ADGRG4 ADGRL4

7.23e-0434973SM00303
DomainGPS

PKD1L3 ADGRG4 ADGRL4

7.88e-0435973PF01825
DomainGPS

PKD1L3 ADGRG4 ADGRL4

8.56e-0436973PS50221
DomainGPS

PKD1L3 ADGRG4 ADGRL4

9.28e-0437973IPR000203
DomainEGF_CA

ADGRL4 FAT1 FBN1 LRP2

1.05e-0386974PF07645
DomainLRR_5

TSHR LHCGR

1.17e-0310972PF13306
DomainLRR_5

TSHR LHCGR

1.17e-0310972IPR026906
DomainEGF_3

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

1.42e-03235976PS50026
DomainEGF

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

1.42e-03235976SM00181
DomainTIL

MUC5AC MUC6

1.70e-0312972PF01826
DomainC8

MUC5AC MUC6

1.70e-0312972PF08742
DomainEGF-like_dom

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

1.90e-03249976IPR000742
DomainUnchr_dom_Cys-rich

MUC5AC MUC6

2.01e-0313972IPR014853
DomainC8

MUC5AC MUC6

2.01e-0313972SM00832
DomainIMPORTIN_B_NT

TNPO1 TNPO2

2.33e-0314972PS50166
DomainEGF-like_CS

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

2.41e-03261976IPR013032
DomainEGF_2

ADGRL4 FAT1 FBN1 CLEC14A NCAN LRP2

2.59e-03265976PS01186
DomainIBN_N

TNPO1 TNPO2

2.68e-0315972PF03810
DomainVWD

MUC5AC MUC6

3.06e-0316972SM00216
DomainVWF_type-D

MUC5AC MUC6

3.06e-0316972IPR001846
DomainIBN_N

TNPO1 TNPO2

3.06e-0316972SM00913
DomainVWFD

MUC5AC MUC6

3.06e-0316972PS51233
DomainVWD

MUC5AC MUC6

3.06e-0316972PF00094
DomainImportin-beta_N

TNPO1 TNPO2

3.45e-0317972IPR001494
DomainVWC_out

MUC5AC MUC6

4.31e-0319972SM00215
DomainZnf_C2H2_jaz

PRDM10 ZNF804B

5.76e-0322972IPR022755
Domainzf-C2H2_jaz

PRDM10 ZNF804B

5.76e-0322972PF12171
DomainCT

MUC5AC MUC6

5.76e-0322972SM00041
DomainHEAT_REPEAT

TNPO1 TNPO2 HEATR6

5.78e-0370973PS50077
Pubmed

A Japanese-specific allele in the GALNT11 gene.

FBN1 ZNF804B CEP152

2.30e-075100320547088
Pubmed

A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.

NALF1 ZNF804B LRP2

6.46e-0613100321079607
Pubmed

Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.

TSHR LHCGR

8.18e-06210022293030
Pubmed

Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.

CDC14C CDC14B

8.18e-062100219923902
Pubmed

The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.

CDC14C CDC14B

8.18e-062100221502810
Pubmed

Transportin-1 and Transportin-2: protein nuclear import and beyond.

TNPO1 TNPO2

8.18e-062100224780099
Pubmed

Clinicopathological features of superficial non-ampurally duodenal epithelial tumor; gastric phenotype of histology correlates to higher malignant potency.

MUC5AC MUC6

8.18e-062100228321513
Pubmed

Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs.

MUC5AC MUC6

8.18e-06210029422745
Pubmed

Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.

CDC14C CDC14B

8.18e-062100218547142
Pubmed

PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.

TLR9 PINK1

8.18e-062100231170232
Pubmed

Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.

MUC5AC MUC6

8.18e-062100212360467
Pubmed

Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.

TSHR LHCGR

8.18e-06210021651314
Pubmed

An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.

TSHR LHCGR

8.18e-062100218162522
Pubmed

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.

TSHR LHCGR

8.18e-062100211312274
Pubmed

ADAMTSL6β protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.

THSD4 FBN1

8.18e-062100221880733
Pubmed

Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution.

MUC5AC MUC6

8.18e-062100211988092
Pubmed

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.

THSD4 FBN1

8.18e-062100219940141
Pubmed

Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins.

TNPO1 TNPO2

8.18e-06210029298975
Pubmed

Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.

TSHR LHCGR

8.18e-062100222309849
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

COPA TNPO2 ZNFX1 ACTN1 FBN1 HEATR6 AP2B1 SACS ZNF451 LRP2 UQCRC1 MED13 PICK1 PINK1

1.88e-0512851001435914814
Pubmed

Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.

CDC14C CDC14B

2.45e-053100221262768
Pubmed

Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.

TSHR LHCGR

2.45e-05310028747461
Pubmed

Mucin expression in reactive gastropathy: an immunohistochemical analysis.

MUC5AC MUC6

2.45e-053100217227128
Pubmed

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

CDC14C CDC14B

2.45e-053100222355704
Pubmed

Mucin phenotype expression of gastric neuroendocrine neoplasms: analysis of histopathology and carcinogenesis.

MUC5AC MUC6

2.45e-053100223828549
Pubmed

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.

TSHR LHCGR

2.45e-053100211847099
Pubmed

CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.

CDC14C CDC14B

2.45e-053100219129509
Pubmed

Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.

MUC5AC MUC6

2.45e-053100218825309
Pubmed

Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.

CDC14C CDC14B

2.45e-053100226283732
Pubmed

Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.

TSHR LHCGR

2.45e-053100215889138
Pubmed

Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.

MUC5AC MUC6

2.45e-053100218300795
Pubmed

A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer.

MUC5AC MUC6

2.45e-053100219924550
Pubmed

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.

TNPO1 TNPO2

2.45e-053100220606625
Pubmed

Involvement of transportin 2-mediated HuR import in muscle cell differentiation.

TNPO1 TNPO2

2.45e-053100217475777
Pubmed

Polymorphisms in innate immunity genes and risk of childhood leukemia.

TLR9 NUDT6 DEFB119 SCNN1A C5AR1 MUC6

3.01e-05206100620438785
Pubmed

Risk of meningioma and common variation in genes related to innate immunity.

TLR9 NUDT6 DEFB119 SCNN1A C5AR1 MUC6

3.09e-05207100620406964
Pubmed

Common variation in genes related to innate immunity and risk of adult glioma.

TLR9 NUDT6 DEFB119 SCNN1A C5AR1 MUC6

3.18e-05208100619423540
Pubmed

Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.

MUC5AC MUC6

4.89e-054100233154304
Pubmed

CDC14A phosphatase is essential for hearing and male fertility in mouse and human.

CDC14C CDC14B

4.89e-054100229293958
Pubmed

Gastric mucin expression in first-degree relatives of gastric cancer patients.

MUC5AC MUC6

4.89e-054100224901817
Pubmed

Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).

MUC5AC MUC6

4.89e-054100236367122
Pubmed

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.

MUC5AC MUC6

4.89e-054100217471237
Pubmed

The mouse secreted gel-forming mucin gene cluster.

MUC5AC MUC6

4.89e-054100214984930
Pubmed

The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import.

TNPO1 TNPO2

4.89e-054100210875935
Pubmed

Karyopherin beta 2B participates in mRNA export from the nucleus.

TNPO1 TNPO2

4.89e-054100212384575
Pubmed

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.

MUC5AC MUC6

4.89e-054100229869461
Pubmed

Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?

MUC5AC MUC6

4.89e-054100220929551
Pubmed

Characterization and potential function of a novel testis-specific nucleoporin BS-63.

TNPO1 MLLT10

4.89e-054100211774384
Pubmed

Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma.

MUC5AC MUC6

4.89e-054100224603585
Pubmed

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.

MUC5AC MUC6

4.89e-054100223807779
Pubmed

MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.

MUC5AC MUC6

4.89e-054100227298226
Pubmed

Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.

MUC5AC MUC6

4.89e-054100217401217
Pubmed

Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.

TNPO1 TNPO2

4.89e-054100215037768
Pubmed

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.

MUC5AC MUC6

4.89e-054100212676567
Pubmed

Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours.

MUC5AC MUC6

4.89e-054100225298197
Pubmed

Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/CCdh1 regulation during meiotic G2/M transition in mouse oocytes.

CDC14C CDC14B

4.89e-054100232341029
Pubmed

The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.

NALF1 UNC79

4.89e-054100232494638
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN1 LRP2 MUC5AC MUC6

5.39e-0571100433541421
Pubmed

Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?

MUC5AC MUC6

8.14e-055100222261707
Pubmed

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency.

COX10 PINK1

8.14e-055100232080200
Pubmed

MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer.

MUC5AC MUC6

8.14e-055100216475027
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

COPA TNPO2 DRG1 EXOC5 SH3PXD2B SACS GPC4 PXN

9.83e-05498100836634849
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

TNPO1 TMEM201 COPA NKRF C2CD5 NMD3 DRG1 AP2B1 LGR6

1.14e-04653100933742100
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC5AC MUC6

1.22e-046100219110483
Pubmed

Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.

TLR9 PINK1

1.22e-046100230449314
Pubmed

Biosynthesis of gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins.

MUC5AC MUC6

1.22e-046100217982272
Pubmed

TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis.

TLR9 PINK1

1.22e-046100235411325
Pubmed

Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing.

CCND2 SCNN1A

1.70e-047100212477808
Pubmed

Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules.

ACTN1 PXN

2.27e-048100220886612
Pubmed

Human transcription factor protein interaction networks.

COPA TNPO2 MLLT10 INO80D CXXC1 NKRF FAT1 FBN1 ZFHX4 ZNF451 LRP2 CEP152 UQCRC1

2.31e-0414291001335140242
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SLC37A3 SLC35B3 MLLT10 CDC14B CDPF1 PCNX2 SH3PXD2B FAT1 PXN MED13 PICK1

3.40e-0411051001135748872
Pubmed

Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.

ACTN1 PXN

3.63e-0410100211113628
Pubmed

Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling.

FBN1 C5AR1

3.63e-0410100230429287
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

COPA SH3PXD2B FAT1 NUDT6 SACS ALPK2

4.06e-04332100637433992
Pubmed

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.

SCNN1A MUC5AC

4.43e-0411100221505443
Pubmed

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.

SH3PXD2B HEATR6 AP2B1 SACS PXN

5.47e-04230100535449600
Pubmed

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

TRAF5 SLC44A2 TLR9 CCND2 SCNN1A

5.58e-04231100521048031
Pubmed

Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7.

CCND2 SCNN1A

6.25e-041310028575777
Pubmed

Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.

LRP2 PICK1

6.25e-0413100212508107
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

SACS LRP2

7.28e-0414100215082773
Pubmed

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.

COPA PXN

8.39e-0415100236963288
Pubmed

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.

TNPO1 ACTN1

8.39e-0415100226403541
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

RAE1 TNPO2 C2CD5 EXOC5 FAT1 GPC4 UQCRC1

8.96e-04533100725544563
Pubmed

Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells.

NDC80 CEP152

9.57e-0416100225833693
Pubmed

PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.

AP2B1 PICK1

9.57e-0416100216055064
Pubmed

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

TSHR CCND2

9.57e-0416100230979723
Pubmed

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.

TNPO1 RAE1

1.08e-0317100210668806
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

C2CD5 DRG1 FAT1 NDC80 AP2B1 PXN

1.08e-03401100625852190
Pubmed

Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.

CDPF1 CLEC14A DGUOK GPC4

1.12e-03157100412466305
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

TNPO1 COPA TNPO2 EXOC5 PRDM10 AP2B1 UQCRC1

1.19e-03560100735241646
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC5AC MUC6

1.22e-0318100218834073
Pubmed

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.

GPC4 MUC5AC

1.22e-0318100236057966
Pubmed

Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.

SCNN1A LRP2

1.36e-0319100219367412
Pubmed

Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.

TSHR LHCGR

1.50e-0320100220716560
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

RAE1 C2CD5 DRG1 NALF1 ZFHX4 ZNF804B

1.57e-03431100633660365
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

TNPO1 RAE1 C2CD5 DRG1 CCND2 GPC4

1.58e-03432100623455922
Pubmed

Proteomic analysis identifies novel binding partners of BAP1.

TNPO1 COPA FAT1

1.61e-0380100334591877
Pubmed

A genome annotation-driven approach to cloning the human ORFeome.

ASPHD2 CDPF1 DRG1 TMEM184B PICK1

1.63e-03294100515461802
Pubmed

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

PRDM10 PRDM12

1.82e-0322100219050759
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

TNPO1 TNPO2 EXOC5 AP2B1

1.96e-03183100423956138
GeneFamilyGlycoprotein hormone receptors

TSHR LHCGR

4.05e-053672199
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

PRDM10 PRDM12

1.77e-03176721197
GeneFamilyArmadillo repeat containing|Importins

TNPO1 TNPO2

1.99e-0318672596
GeneFamilyCD molecules|Mucins

MUC5AC MUC6

2.71e-0321672648
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 LAPTM4A TNFRSF11B FAT1 ZFHX4 GPC4 DISP1

2.74e-0719310070f2167eef8203a5659c8c72e4e77646003d64797
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LAPTM4A TNFRSF11B FAT1 GPC4 LRP2 ALPK2

5.06e-0619410068ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAPTM4A TNFRSF11B CCND2 FAT1 GPC4 ALPK2

5.37e-06196100634e79918a448f6c19b87e1b1ce13c012b24be1f8
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAPTM4A TNFRSF11B CCND2 FAT1 GPC4 ALPK2

5.37e-0619610068f82e01ca50aa4cd6149547505b4474a02fad618
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VPS8 MLLT10 FAT1 PRDM10 SCNN1A ALPK2

5.86e-061991006174f6013af6eafa577f84205a62927f2b367fda3
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 ZFHX4 GPC4

6.03e-06200100609537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 ZFHX4 GPC4

6.03e-06200100608bf8c00eee6468215edb3611296bfc8784c4d56
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LAPTM4A TNFRSF11B FAT1 GPC4 LRP2 ALPK2

6.03e-062001006105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|368C / Donor, Lineage, Cell class and subclass (all cells)

TNPO2 SIDT1 PRDM10 LRP2 LGR6

2.71e-05156100525b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TNFRSF11B FAT1 GPC4 LRP2 ALPK2

3.87e-051681005a086c306be430adf0632ba53e98cd8014d2de330
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|Myeloid_cells / Location, Cell class and cell subclass

TMEM201 CARF SCNN1A MUC5AC DISP1

3.98e-051691005dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

TNFRSF11B SACS GPC4 LRP2 ALPK2

4.32e-05172100536a96714a0eb6ac438648135336c9791881ddadb
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

THSD4 ADGRG4 LHCGR ZNF804B LGR6

5.09e-0517810058ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

THSD4 ADGRG4 LHCGR ZNF804B LGR6

5.09e-0517810056c91331196696e0cf239d105f458e3230659fa38
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAT1 NALF1 GPC4 LRP2 ALPK2

5.09e-051781005544379f5a6145429762258d426b876bb36c112f5
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

CCND2 NALF1 GPC4 ZAR1 ALPK2

5.23e-051791005e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNFRSF11B FAT1 GPC4 LRP2 ALPK2

5.51e-0518110056956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNFRSF11B FAT1 NALF1 GPC4 ALPK2

6.11e-05185100534fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNFRSF11B FAT1 NALF1 GPC4 ALPK2

6.11e-0518510058816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ACTN1 ADGRL4 NALF1 CLEC14A DGKI

6.76e-0518910057346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 LAPTM4A TNFRSF11B FAT1 DISP1

6.93e-051901005b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FAM221A SCNN1A LRP2 PRRG4 MUC5AC

7.11e-05191100505731ece7867659c662f952812805f947032fe10
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LAPTM4A TNFRSF11B FAT1 GPC4 ALPK2

7.46e-051931005ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

THSD4 TRAF5 ACTN1 FAT1 LGR6

7.46e-051931005000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ADGRL4 FBN1 NALF1 CLEC14A

7.46e-0519310052e72309607902dabe3218888b22a77fe941f3570
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FBN1 ZFHX4 GPC4 LRP2

8.03e-0519610056bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 FBN1 ZFHX4 GPC4 LRP2

8.03e-051961005c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TNFRSF11B SH3PXD2B FAT1 ZFHX4 GPC4

8.42e-0519810056a539d3b47bd2d4a7ad5c67cad23facffc0ac45f
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD4 LAPTM4A ACTN1 FBN1 GPC4

8.62e-05199100536c1deac7ef0f9ebde6b2f7a63f7daa03d8c139a
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THSD4 FAT1 FBN1 ZFHX4 GPC4

8.62e-05199100538cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 GPC4

8.83e-052001005c5e051f1aac8dda376c342a9932785a23450e073
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

CCND2 FAT1 ZFHX4 NDC80 GPC4

8.83e-052001005474e6ab48f199315f3cca86b81fdf54e0461b7b8
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 GPC4

8.83e-0520010059d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

THSD4 FAT1 FBN1 ZFHX4 GPC4

8.83e-052001005a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 GPC4

8.83e-0520010055ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 GPC4

8.83e-0520010058988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 FBN1 GPC4

8.83e-05200100567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD4 ACTN1 FAT1 GPC4 LGR6

8.83e-052001005dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

CCND2 FAT1 ZFHX4 NDC80 GPC4

8.83e-05200100501a29651e9bb64ef7666c6a61ec396eeb88b2816
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRAF5 TNFRSF11B SACS TMEM145

9.59e-051061004005ca899efc5ad0c9c17b2697022b594c8cea2c1
Diseaseintellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (implicated_via_orthology)

TNPO1 TNPO2

1.05e-052962DOID:0081262 (implicated_via_orthology)
Diseaseanorexia nervosa

ADGRL4 NALF1 ZNF804B LRP2

8.18e-0570964MONDO_0005351
Diseasemucinous adenocarcinoma (is_marker_for)

MUC5AC MUC6

1.04e-045962DOID:3030 (is_marker_for)
Diseasemitral valve prolapse (is_implicated_in)

TSHR FBN1

3.72e-049962DOID:988 (is_implicated_in)
Diseasegranulosa cell tumor (is_marker_for)

CCND2 LHCGR

5.65e-0411962DOID:2999 (is_marker_for)
Diseaseisoleucine measurement

TNPO1 DRG1 ZNF804B

8.16e-0456963EFO_0009793
Diseasewhite matter integrity

MLLT10 TNFRSF11B CARF PICK1

8.74e-04130964EFO_0004641
Diseasegastric ulcer (implicated_via_orthology)

MUC5AC MUC6

9.29e-0414962DOID:10808 (implicated_via_orthology)
Diseasecholangiocarcinoma (is_marker_for)

PRRG4 MUC5AC MUC6

1.20e-0364963DOID:4947 (is_marker_for)
Diseaselupus nephritis (is_marker_for)

TLR9 TNFRSF11B

1.38e-0317962DOID:0080162 (is_marker_for)
DiseaseUterine leiomyoma, estrogen-receptor positive breast cancer

MLLT10 CDPF1

1.55e-0318962EFO_1000649, HP_0000131
DiseaseArthrogryposis

VPS8 GFM2

2.11e-0321962C0003886
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

SLC44A2 F11

2.11e-0321962EFO_0004286, EFO_0004792
Diseasevenous thromboembolism, tissue plasminogen activator measurement

SLC44A2 F11

2.53e-0323962EFO_0004286, EFO_0004791
Diseasenephrotic syndrome (implicated_via_orthology)

FAT1 SCNN1A

2.76e-0324962DOID:1184 (implicated_via_orthology)
DiseaseTEMPS-A questionnaire

XKR9 SGCZ

2.99e-0325962EFO_0004783
DiseaseLeft ventricular mass to end-diastolic volume ratio

CDPF1 PXN

2.99e-0325962EFO_0010556
DiseaseAcute kidney injury

TACR3 DISP1

2.99e-0325962HP_0001919

Protein segments in the cluster

PeptideGeneStartEntry
IQEEYYRLFKNVPCC

ADGRL4

671

Q9HBW9
ICQTMKCQRYQTPYL

CEP152

1626

O94986
YYDSPSVNARCQKIC

ACTN1

466

P12814
LKCRAPEVSQYIYQV

AP2B1

916

P63010
CNRYPCIKEVECYVS

GJD2

231

Q9UKL4
ISYVPYSCVCQVIIK

ADGRG4

2321

Q8IZF6
VQASPKDQGLYYCCI

ALPK2

1846

Q86TB3
PLNLAMVYRYCCKIN

CDC14B

91

O60729
NIFLYTCCYTPLKRI

COX10

266

Q12887
YLQASPQVCLKRLYQ

DGUOK

191

Q16854
YSKRFCLPCVRENIN

CDPF1

81

Q6NVV7
VSFAYINCCINPIIY

C5AR1

286

P21730
PLNLAMVYRYCCKIN

CDC14C

61

A4D256
CTNVPRKCTKYNAVY

DISP1

411

Q96F81
IPISYEQIYSCVYKC

CACUL1

156

Q86Y37
YALCIPYCKSRAINH

OR2L2

161

Q8NH16
VLQLPERCYCADVIY

RAE1

166

P78406
ACKYNALALQCYNPV

KLHL30

431

Q0D2K2
SYQCPYCNRKRAELA

C8orf48

196

Q96LL4
RYLPQCSYFKCVQKD

CCND2

36

P30279
LYTGQRCQLSPYCKD

FAT1

4081

Q14517
KRCVYQACNYEETFP

MUC6

616

Q6W4X9
IICACYIKIYFAVRN

LHCGR

541

P22888
GNRVYIPCIYVLNKI

DRG1

236

Q9Y295
PKLRILEVPYAYQCC

LGR6

466

Q9HBX8
VTVKPCYNYCSNIMR

GPC4

261

O75487
CYKYINNRNVPEIAV

LAPTM4A

186

Q15012
RSCQLYKATCPARIY

CARF

306

Q8N187
QIITYSRPIYFCVLC

PCNX2

901

A6NKB5
LVMKNYPCTLRQYLC

PINK1

316

Q9BXM7
ICRLKPYSFTINFCQ

NUDT6

226

P53370
LVYCNGSKCQKYLPE

HEATR6

146

Q6AI08
YTKCHNSNICIPRVY

LRP2

2826

P98164
CYNYQIRVQCCTPLP

MUC5AC

1466

P98088
IKPNRDYFCQYCDKV

PRDM10

766

Q9NQV6
ERPYKCQVCQSAYSQ

PRDM12

296

Q9H4Q4
RASCKKNEQPYLYCR

DEFB119

36

Q8N690
VREICSKYIYDQCPA

UQCRC1

441

P31930
RCYYCNGPILDKVVT

PXN

416

P49023
QYTNACVKVCAYVRK

EXOC5

571

O00471
LQNGYVYCQSPECVR

ASPHD2

101

Q6ICH7
CDVYNPQSKTYCKRL

CXXC1

531

Q9P0U4
TKLPYCRENVCLAYG

DCAF12

291

Q5T6F0
KFQCIVFLNIPRYCA

DGKI

601

O75912
PVNVTDYCQLVRYLC

FBN1

446

P35555
LPIYVTRVKGNNVYC

COPA

566

P53621
PSAKYCQVVCTYHPR

F11

41

P03951
CEYVAKYNSQRCTNP

INO80D

51

Q53TQ3
YQPICYIFKPCQSAL

KRTAP29-1

206

A8MX34
ICVEKCPDRYLTYLN

SLC44A2

111

Q8IWA5
CQCRAYLYVPLNGSQ

FAM221A

106

A4D161
LYPSKYTQQVCIHSC

SCNN1A

406

P37088
QPDLYCLVKALYNCI

SACS

2971

Q9NZJ4
TYCYNCRKQKVPDVL

C2CD5

481

Q86YS7
LSPRVIQNIIYYKCN

PHKB

826

Q93100
AKFPTRYCYCLNNRT

HHLA1

131

C9JL84
PSVYINNICCYKIRA

GFM2

16

Q969S9
VQYKRGVCQQFCLPS

RNF157

161

Q96PX1
CYSCPNEQRYIVRIL

TMEM184B

71

Q9Y519
CIQACKTNPEYIYAP

NKRF

206

O15226
CQPYRSAFYILEQQC

NBPF19

626

A0A087WUL8
CQPYRSAFYILEQQC

NBPF19

1846

A0A087WUL8
CQPYRSAFYILEQQC

NBPF19

3066

A0A087WUL8
NYNLPYVCKKGTVLC

NCAN

1201

O14594
LVCYYAFIQGCQLKQ

PKD1L3

1476

Q7Z443
YLNYPTQVIFKCCKL

SLC35B3

166

Q9H1N7
ISYPACLVQCYLFIA

OR5M8

91

Q8NGP6
LNPKQDYCSICLQQY

VPS8

1251

Q8N3P4
TVYELCVCPNGKLYL

SGCZ

266

Q96LD1
YVYKPENCQILVGCS

MED13

901

Q9UHV7
YNPIIYCCLNKRFRA

TACR3

351

P29371
CLCVSFKNIVYTYRI

SH2D1B

41

O14796
LYVYCSNAPGCNAKV

TRAF5

106

O00463
QSVPHDRYNKTCYIC

MLLT10

126

P55197
ANGYLCKYQFEVLCP

CLEC14A

166

Q86T13
YNPVKQQLVRYATSC

COASY

126

Q13057
ILYCLAKYPEHQQRC

CYP4Z1

326

Q86W10
PLNCKIYNYLNRIGC

ZNF451

926

Q9Y4E5
AVIGDIYQCKLCNYN

ZFHX4

911

Q86UP3
LYCSPVCKELQYVKQ

TNFRSF11B

81

O00300
CGNQRYKRYSPQSCL

ZNF804B

691

A4D1E1
AQVKAISFYQACCLP

SLC37A3

276

Q8NCC5
GNCYYKNPCRQALEV

TLR9

176

Q9NR96
YCKALIQLPPYISQC

SH3PXD2B

101

A1X283
VFYTDCIQQCSRPLY

SIDT1

666

Q9NXL6
YCEPVYQRCVTLVQK

TNPO2

601

O14787
YYLCITKCNRLQHPC

PRRG4

136

Q9BZD6
YKLCRPCQAAVEYYI

TMEM201

161

Q5SNT2
PYCEPVYQRCVNLVQ

TNPO1

611

Q92973
CKYFLCQEYLPSQIT

ZNFX1

1141

Q9P2E3
KPYQCNECQKLFCYR

ZNF883

291

P0CG24
CIGAYRQYKLCNTNV

THSD4

291

Q6ZMP0
AQYCPCLYIVQVFDN

PICK1

41

Q9NRD5
FRYPEAKCCQNILLY

TMEM145

61

Q8NBT3
QNTKCPMSCYYIVRV

XKR9

281

Q5GH70
KQFCRTCQKSYNPYR

ZAR1

356

Q86SH2
YNPYRVEDITCQSCK

ZAR1

366

Q86SH2
IVCCCYVKIYITVRN

TSHR

596

P16473
VLKYCSCPQLRHYFQ

UNC79

1366

Q9P2D8
VCSCLKQPKVRYYDL

NLRP13

431

Q86W25
KQYCLEVQTRCPFIL

NALF1

331

B1AL88
FLQCTVPCRYKASQR

NMD3

211

Q96D46
GANCLVKYRAQVYVP

NDC80

446

O14777