Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	propionate-CoA ligase activity	ACSS1 ACSS2	6.83e-05	4	68	2	GO:0050218
GeneOntologyMolecularFunction	short-chain fatty acid-CoA ligase activity	ACSS1 ACSS2	6.83e-05	4	68	2	GO:0031955
GeneOntologyMolecularFunction	acetate-CoA ligase activity	ACSS1 ACSS2	6.83e-05	4	68	2	GO:0003987
GeneOntologyMolecularFunction	protein-disulfide reductase activity	PDIA6 DNAJC10 TMX3	2.49e-04	36	68	3	GO:0015035
GeneOntologyMolecularFunction	fucose binding	ACR CLEC10A	3.16e-04	8	68	2	GO:0042806
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	PDIA6 DNAJC10 TMX3	4.23e-04	43	68	3	GO:0015036
GeneOntologyMolecularFunction	endopeptidase activity	PRSS8 ADAMTS7 ADAMTS6 ACR TMPRSS4 KDM8 SENP7	6.40e-04	430	68	7	GO:0004175
GeneOntologyMolecularFunction	carbohydrate binding	MAN2B2 MRC2 ACAN ACR CLEC1A CLEC10A	6.51e-04	310	68	6	GO:0030246
GeneOntologyMolecularFunction	lyase activity	ALKBH1 NPR2 SGPL1 RNASET2 CA10	7.79e-04	212	68	5	GO:0016829
GeneOntologyMolecularFunction	peptide hormone binding	CMKLR2 NPR2 PRLR	8.73e-04	55	68	3	GO:0017046
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors	PDIA6 DNAJC10 TMX3	9.69e-04	57	68	3	GO:0016667
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNC2 KCNC4	1.50e-03	17	68	2	GO:0099508
GeneOntologyMolecularFunction	peptidase activity	PRSS8 ADAMTS7 ADAMTS6 ACR TMPRSS4 KDM8 MINDY1 SENP7	1.66e-03	654	68	8	GO:0008233
GeneOntologyMolecularFunction	AMP binding	ACSS1 ACSS2	2.30e-03	21	68	2	GO:0016208
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing S-S bonds	PDIA6 TMX3	2.53e-03	22	68	2	GO:0016864
GeneOntologyMolecularFunction	protein disulfide isomerase activity	PDIA6 TMX3	2.53e-03	22	68	2	GO:0003756
GeneOntologyMolecularFunction	collagen binding	FN1 MRC2 SMAD7	2.67e-03	81	68	3	GO:0005518
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	NPR2 RNASET2	3.26e-03	25	68	2	GO:0016849
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSS1 ACSS2	3.52e-03	26	68	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSS1 ACSS2	3.80e-03	27	68	2	GO:0016405
GeneOntologyMolecularFunction	D-mannose binding	ACR CLEC10A	3.80e-03	27	68	2	GO:0005537
GeneOntologyMolecularFunction	NAD+-protein poly-ADP-ribosyltransferase activity	PARP11 PARP1	4.08e-03	28	68	2	GO:0003950
GeneOntologyMolecularFunction	delayed rectifier potassium channel activity	KCNC2 KCNC4	4.08e-03	28	68	2	GO:0005251
GeneOntologyMolecularFunction	hyaluronic acid binding	ACAN IMPG2	4.37e-03	29	68	2	GO:0005540
GeneOntologyMolecularFunction	NAD+-protein ADP-ribosyltransferase activity	PARP11 PARP1	4.67e-03	30	68	2	GO:1990404
GeneOntologyBiologicalProcess	propionate biosynthetic process	ACSS1 ACSS2	1.04e-05	2	67	2	GO:0019542
GeneOntologyBiologicalProcess	acetate biosynthetic process	ACSS1 ACSS2	1.04e-05	2	67	2	GO:0019413
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process from acetate	ACSS1 ACSS2	1.04e-05	2	67	2	GO:0019427
GeneOntologyBiologicalProcess	cellular response to mercury ion	FN1 AQP2	6.21e-05	4	67	2	GO:0071288
GeneOntologyBiologicalProcess	short-chain fatty acid biosynthetic process	ACSS1 ACSS2	6.21e-05	4	67	2	GO:0051790
GeneOntologyBiologicalProcess	acetate metabolic process	ACSS1 ACSS2	6.21e-05	4	67	2	GO:0006083
GeneOntologyBiologicalProcess	negative regulation of Ras protein signal transduction	NF1 RASA4 RASA4B	1.01e-04	28	67	3	GO:0046580
GeneOntologyBiologicalProcess	propionate metabolic process	ACSS1 ACSS2	1.03e-04	5	67	2	GO:0019541
Domain	TSP_1	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B UNC5D	9.81e-08	63	67	6	PF00090
Domain	TSP1	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B UNC5D	1.19e-07	65	67	6	SM00209
Domain	TSP1_rpt	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B UNC5D	1.19e-07	65	67	6	IPR000884
Domain	TSP1	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B UNC5D	1.19e-07	65	67	6	PS50092
Domain	Ac_CoA_lig	ACSS1 ACSS2	1.27e-05	2	67	2	IPR011904
Domain	RasGAP	NF1 RASA4 RASA4B	1.56e-05	14	67	3	SM00323
Domain	RasGAP_CS	NF1 RASA4 RASA4B	1.56e-05	14	67	3	IPR023152
Domain	RasGAP	NF1 RASA4 RASA4B	1.95e-05	15	67	3	PF00616
Domain	RAS_GTPASE_ACTIV_1	NF1 RASA4 RASA4B	1.95e-05	15	67	3	PS00509
Domain	RAS_GTPASE_ACTIV_2	NF1 RASA4 RASA4B	1.95e-05	15	67	3	PS50018
Domain	Thioredoxin_CS	PDIA6 DNAJC10 TMX3	2.89e-05	17	67	3	IPR017937
Domain	RasGAP_dom	NF1 RASA4 RASA4B	3.46e-05	18	67	3	IPR001936
Domain	-	RASA4 RASA4B	3.79e-05	3	67	2	4.10.1130.10
Domain	K_chnl_volt-dep_Kv3	KCNC2 KCNC4	7.57e-05	4	67	2	IPR003974
Domain	ACAS_N	ACSS1 ACSS2	7.57e-05	4	67	2	PF16177
Domain	ACAS_N	ACSS1 ACSS2	7.57e-05	4	67	2	IPR032387
Domain	THIOREDOXIN_1	PDIA6 DNAJC10 TMX3	9.59e-05	25	67	3	PS00194
Domain	Thioredoxin	PDIA6 DNAJC10 TMX3	1.85e-04	31	67	3	PF00085
Domain	Rho_GTPase_activation_prot	NF1 RASA4 RASA4B CHN1	2.81e-04	88	67	4	IPR008936
Domain	Disulphide_isomerase	PDIA6 TMX3	3.50e-04	8	67	2	IPR005788
Domain	Thioredoxin_domain	PDIA6 DNAJC10 TMX3	4.27e-04	41	67	3	IPR013766
Domain	BTK	RASA4 RASA4B	4.49e-04	9	67	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	4.49e-04	9	67	2	IPR001562
Domain	BTK	RASA4 RASA4B	4.49e-04	9	67	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	4.49e-04	9	67	2	PS51113
Domain	THIOREDOXIN_2	PDIA6 DNAJC10 TMX3	4.91e-04	43	67	3	PS51352
Domain	-	FN1 MRC2	9.64e-04	13	67	2	2.10.10.10
Domain	Thioredoxin	PDIA6 TMX3	9.64e-04	13	67	2	IPR005746
Domain	FN_type2_col-bd	FN1 MRC2	1.12e-03	14	67	2	IPR000562
Domain	FN2_2	FN1 MRC2	1.12e-03	14	67	2	PS51092
Domain	fn2	FN1 MRC2	1.12e-03	14	67	2	PF00040
Domain	FN2_1	FN1 MRC2	1.12e-03	14	67	2	PS00023
Domain	FN2	FN1 MRC2	1.12e-03	14	67	2	SM00059
Domain	-	RASA4 RASA4B	1.47e-03	16	67	2	1.10.506.10
Domain	Poly(ADP-ribose)pol_cat_dom	PARP11 PARP1	1.67e-03	17	67	2	IPR012317
Domain	PARP_CATALYTIC	PARP11 PARP1	1.67e-03	17	67	2	PS51059
Domain	PARP	PARP11 PARP1	1.67e-03	17	67	2	PF00644
Domain	AMP-bd_C	ACSS1 ACSS2	1.67e-03	17	67	2	IPR025110
Domain	AMP-binding_C	ACSS1 ACSS2	1.67e-03	17	67	2	PF13193
Domain	-	PARP11 PARP1	1.67e-03	17	67	2	3.90.228.10
Domain	PLAC	ADAMTS7 ADAMTS6	2.08e-03	19	67	2	PS50900
Domain	PLAC	ADAMTS7 ADAMTS6	2.08e-03	19	67	2	IPR010909
Domain	C_TYPE_LECTIN_1	MRC2 CLEC1A CLEC10A	2.98e-03	80	67	3	PS00615
Domain	ADAM_spacer1	ADAMTS7 ADAMTS6	3.06e-03	23	67	2	IPR010294
Domain	ADAM_spacer1	ADAMTS7 ADAMTS6	3.06e-03	23	67	2	PF05986
Domain	WGR_domain	PARP11 PARP1	3.33e-03	24	67	2	IPR008893
Domain	Peptidase_M12B_ADAM-TS	ADAMTS7 ADAMTS6	3.33e-03	24	67	2	IPR013273
Domain	Lectin_C	MRC2 CLEC1A CLEC10A	3.42e-03	84	67	3	PF00059
Domain	CLECT	MRC2 CLEC1A CLEC10A	3.42e-03	84	67	3	SM00034
Domain	C_TYPE_LECTIN_2	MRC2 CLEC1A CLEC10A	3.53e-03	85	67	3	PS50041
Domain	C-type_lectin-like	MRC2 CLEC1A CLEC10A	3.65e-03	86	67	3	IPR001304
Domain	AMP-binding_CS	ACSS1 ACSS2	3.90e-03	26	67	2	IPR020845
Domain	TRYPSIN_SER	PRSS8 ACR TMPRSS4	4.15e-03	90	67	3	IPR033116
Domain	K_chnl_volt-dep_Kv	KCNC2 KCNC4	4.20e-03	27	67	2	IPR003968
Domain	FN3	KIAA0319 FN1 LRRN4CL PRLR	4.39e-03	185	67	4	SM00060
Domain	AMP_BINDING	ACSS1 ACSS2	4.51e-03	28	67	2	PS00455
Domain	-	MRC2 CLEC1A CLEC10A	5.12e-03	97	67	3	3.10.100.10
Domain	AMP-binding	ACSS1 ACSS2	5.17e-03	30	67	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSS1 ACSS2	5.17e-03	30	67	2	IPR000873
Domain	C-type_lectin-like/link	MRC2 CLEC1A CLEC10A	5.41e-03	99	67	3	IPR016186
Domain	Kringle-like	FN1 MRC2	5.87e-03	32	67	2	IPR013806
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B	3.56e-07	39	54	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B	3.56e-07	39	54	5	MM15165
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B	5.92e-06	68	54	5	M27303
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	THSD7A ADAMTS7 ADAMTS6 ACAN CFP THSD7B	1.70e-05	143	54	6	M27275
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B	5.90e-05	109	54	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B	6.43e-05	111	54	5	M27416
Pathway	REACTOME_REGULATION_OF_RAS_BY_GAPS	NF1 PSME4 RASA4 RASA4B	1.16e-04	66	54	4	MM15261
Pathway	REACTOME_DISEASES_OF_METABOLISM	THSD7A ADAMTS7 ADAMTS6 ACAN CFP THSD7B	3.71e-04	250	54	6	M27554
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	CCNT2 PARP1 SMAD7	5.11e-04	41	54	3	MM14876
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	THSD7A ADAMTS7 ADAMTS6 CFP THSD7B	4.11e-07	75	69	5	20637190
Pubmed	Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress.	ATG5 APC	3.88e-06	2	69	2	34138755
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	3.88e-06	2	69	2	11448776
Pubmed	Outcome of lumbar epidural steroid injection is predicted by assay of a complex of fibronectin and aggrecan from epidural lavage.	FN1 ACAN	3.88e-06	2	69	2	21224775
Pubmed	The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma.	ACSS1 ACSS2	3.88e-06	2	69	2	19617323
Pubmed	Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.	ACSS1 ACSS2	3.88e-06	2	69	2	11150295
Pubmed	Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.	ACSS1 ACSS2	3.88e-06	2	69	2	27539851
Pubmed	Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in multiple intestinal neoplasia (Min) mice.	APC TNS4	3.88e-06	2	69	2	32567731
Pubmed	Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice.	PARP11 PARP1	3.88e-06	2	69	2	25673562
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	3.88e-06	2	69	2	16041389
Pubmed	The human protein disulfide isomerase gene family.	PDIA6 DNAJC10 TMX3	4.11e-06	16	69	3	23245351
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NF1 FAM120A THSD7A DNAJC10 FN1 ZC3H15 SGPL1 APC	4.60e-06	475	69	8	31040226
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FN1 ADAMTS6 ACAN	5.97e-06	18	69	3	35503090
Pubmed	BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response.	FN1 ACAN APC	8.32e-06	20	69	3	29483282
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	1.16e-05	3	69	2	25637021
Pubmed	Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.	KCNC2 KCNC4	1.16e-05	3	69	2	1740329
Pubmed	A functional role for Smad7 in sustaining colon cancer cell growth and survival.	APC SMAD7	1.16e-05	3	69	2	24556688
Pubmed	Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.	ACSS1 ACSS2	1.16e-05	3	69	2	16788062
Pubmed	Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.	NSD2 APC	1.16e-05	3	69	2	35230972
Pubmed	Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes.	PRSS8 TMPRSS4	1.16e-05	3	69	2	12149280
Pubmed	MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.	PARP1 APC	1.16e-05	3	69	2	29880585
Pubmed	Prolactin Action Is Necessary for Parental Behavior in Male Mice.	PRLR SLC17A6	1.16e-05	3	69	2	36163141
Pubmed	Poly(ADP-ribose) polymerase-1 affects vasopressin-mediated AQP2 expression in collecting duct cells of the kidney.	PARP1 AQP2	1.16e-05	3	69	2	37855039
Pubmed	Heterozygous deletion of ATG5 in Apc(Min/+) mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma.	ATG5 APC	1.16e-05	3	69	2	25695667
Pubmed	Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.	KCNC2 KCNC4	2.32e-05	4	69	2	21912965
Pubmed	APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.	APC SMAD7	2.32e-05	4	69	2	22496417
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	2.32e-05	4	69	2	16234249
Pubmed	Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage.	PRLR SMAD7	2.32e-05	4	69	2	32286456
Pubmed	Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.	ACSS1 ACSS2	2.32e-05	4	69	2	16790548
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	2.32e-05	4	69	2	21460216
Pubmed	Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.	PRSS8 TMPRSS4	2.32e-05	4	69	2	16524950
Pubmed	Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.	SGPL1 APC	2.32e-05	4	69	2	17090686
Pubmed	Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior.	PRLR SLC17A6	2.32e-05	4	69	2	28923971
Pubmed	Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.	FN1 DPYSL5 CHN1	2.92e-05	30	69	3	18055048
Pubmed	A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.	APC CA10 UNC5D	3.56e-05	32	69	3	24192035
Pubmed	ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling.	NPR2 AQP2	3.86e-05	5	69	2	23324181
Pubmed	Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1.	FN1 ACAN	3.86e-05	5	69	2	16061471
Pubmed	Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling.	UNC5D SLC17A6	3.86e-05	5	69	2	37557174
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PHKA2 PDIA6 FAM120A PSME4 DNAJC10 SGPL1 APC ELP1	4.37e-05	650	69	8	38777146
Pubmed	Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation.	PDIA6 TMX3	5.79e-05	6	69	2	19995400
Pubmed	Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.	APC AQP2	5.79e-05	6	69	2	15550389
Pubmed	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.	PARP1 FN1 APC	7.01e-05	40	69	3	29180744
Pubmed	Tumor suppressor gene mutations in mice.	NF1 APC	8.09e-05	7	69	2	8982467
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NEMP1 PSME4 NSD2 MRC2 FNBP4 TMX3 MINDY1	8.65e-05	529	69	7	14621295
Pubmed	Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.	RASA4 RASA4B PRLR	9.99e-05	45	69	3	19877281
Pubmed	ATP-citrate lyase promotes axonal transport across species.	ELP1 ACSS2	1.08e-04	8	69	2	34620845
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	1.08e-04	8	69	2	10810084
Pubmed	Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei.	ACAN SLC17A6	1.08e-04	8	69	2	19741118
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	KIAA0319 THSD7A FNBP4 THSD7B	1.33e-04	130	69	4	12421765
Pubmed	Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.	CELSR1 FN1	1.38e-04	9	69	2	28705793
Pubmed	Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.	FN1 ACAN	1.38e-04	9	69	2	15296947
Pubmed	Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.	KCNC2 APC	1.73e-04	10	69	2	26245956
Pubmed	Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.	CELSR1 FN1	1.73e-04	10	69	2	26989131
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS7 ADAMTS6	1.73e-04	10	69	2	11167130
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	FN1 ACAN	2.11e-04	11	69	2	38750698
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	NF1 FN1 SGPL1 ACAN APC ELP1	2.14e-04	430	69	6	32581705
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	ATG5 CMKLR2 NF1 SGPL1 APC ELP1 TMPRSS4 ATP13A3 PRLR SMAD7	2.25e-04	1293	69	10	15342556
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PARP1 NF1 DNAJC10 FNBP4 APC ELP1	2.42e-04	440	69	6	34244565
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	CMKLR2 CCNT2 MAN2B2 DNAJC10 THSD7B CHN1	2.48e-04	442	69	6	15815621
Pubmed	Mouse models in tumor suppression.	NF1 APC	2.53e-04	12	69	2	9917000
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CCNT2 PARP1 PDIA6 DNAJC10 NSD2 ZC3H15 DPYSL5 FNBP4 APC	2.80e-04	1082	69	9	38697112
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	PARP1 NF1 APC	2.99e-04	65	69	3	27453043
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ATG5 ALKBH1 PARP1 PDIA6 NF1 FAM120A PSME4 FN1 SGPL1 ELP1	3.23e-04	1353	69	10	29467282
Pubmed	An analysis of expression patterns of genes encoding proteins with catalytic activities.	ACSS1 RNASET2 CA10	3.27e-04	67	69	3	17626619
Pubmed	A targeted mutation of Nkd1 impairs mouse spermatogenesis.	FN1 APC	3.48e-04	14	69	2	15546883
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	PARP1 NF1 APC	3.88e-04	71	69	3	28319113
Pubmed	HIV-host interactome revealed directly from infected cells.	NEMP1 PDIA6 DNAJC10 TMX3	3.89e-04	172	69	4	27375898
Pubmed	GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.	PARP1 FAM120A	4.01e-04	15	69	2	31417184
Pubmed	Muscleblind-like 1 is required for normal heart valve development in vivo.	FN1 ACAN	4.01e-04	15	69	2	26472242
Pubmed	Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.	FN1 SMAD7	4.01e-04	15	69	2	23011393
Pubmed	Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.	MRC2 CLEC10A	4.01e-04	15	69	2	28580280
Pubmed	Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.	FN1 ACAN	4.01e-04	15	69	2	38018454
Pubmed	Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system.	APC SMAD7	4.57e-04	16	69	2	22365546
Pubmed	Family-wide analysis of poly(ADP-ribose) polymerase activity.	PARP11 PARP1	4.57e-04	16	69	2	25043379
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DNAH12 DNAJC10 FN1 DPYSL5 FNBP4 MINDY1	4.63e-04	497	69	6	36774506
Pubmed	ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.	ADAMTS7 ADAMTS6	5.18e-04	17	69	2	10464288
Pubmed	Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype.	APC ELP1	5.18e-04	17	69	2	33976153
Pubmed	Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2.	ACSS1 ACSS2	5.81e-04	18	69	2	15769905
Pubmed	Hirschsprung Disease Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	NF1 ELP1	5.81e-04	18	69	2	20301612
Pubmed	Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs.	FN1 ACAN	5.81e-04	18	69	2	12571105
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NEMP1 PDIA6 CELSR1 NF1 MAN2B2 DNAJC10 MRC2 SGPL1 TMX3	5.97e-04	1201	69	9	35696571
Pubmed	Gene expression analysis of the embryonic subplate.	FN1 CSMD3 UNC5D SLC17A6	6.35e-04	196	69	4	21862448
Pubmed	Proteostasis is essential during cochlear development for neuron survival and hair cell polarity.	NF1 ELP1	6.49e-04	19	69	2	31321879
Pubmed	The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.	ADAMTS7 ACAN	6.49e-04	19	69	2	29618652
Pubmed	Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.	NF1 APC	6.49e-04	19	69	2	25535838
Pubmed	Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.	FN1 APC	6.49e-04	19	69	2	30760929
Pubmed	¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.	KDM8 MINDY1	7.20e-04	20	69	2	25849460
Pubmed	Use of (alternative) coreceptors for HIV entry.	CMKLR2 CXCR6	7.95e-04	21	69	2	22842622
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	PRSS8 TMPRSS4	7.95e-04	21	69	2	19592578
Pubmed	Mechanical load regulates bone growth via periosteal Osteocrin.	NPR2 FN1	8.73e-04	22	69	2	34260913
Pubmed	Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.	UNC5D SLC17A6	8.73e-04	22	69	2	22726835
Pubmed	Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.	FN1 ACAN	8.73e-04	22	69	2	27527664
Pubmed	Mapping wild-type and R345W fibulin-3 intracellular interactomes.	PDIA6 DNAJC10	8.73e-04	22	69	2	27777122
Pubmed	Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.	PRSS8 KCNC2	9.55e-04	23	69	2	37873566
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACSS1 ACSS2	9.55e-04	23	69	2	14662765
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	ATG5 PARP1 DNAJC10 APC	1.03e-03	223	69	4	34226595
Pubmed	Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.	NF1 APC	1.04e-03	24	69	2	18371380
Pubmed	Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.	PDIA6 FN1	1.04e-03	24	69	2	15308636
Pubmed	Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling.	FN1 SMAD7	1.04e-03	24	69	2	16943282
Pubmed	The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.	NF1 FN1	1.04e-03	24	69	2	10021345
GeneFamily	Protein disulfide isomerases	PDIA6 DNAJC10 TMX3	3.05e-05	21	53	3	692
GeneFamily	C-type lectin domain family	MRC2 CLEC1A CLEC10A	3.52e-04	47	53	3	494
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	3.74e-04	10	53	2	830
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PARP11 PARP1	1.11e-03	17	53	2	684
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS7 ADAMTS6	1.40e-03	19	53	2	50
GeneFamily	Acyl-CoA synthetase family	ACSS1 ACSS2	2.62e-03	26	53	2	40
GeneFamily	Potassium voltage-gated channels	KCNC2 KCNC4	6.12e-03	40	53	2	274
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	FN1 TNS4 CSMD3 CA10 UNC5D	7.94e-06	176	69	5	fc5787946f5a10056d326d070620575ae4081836
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	FN1 TNS4 CSMD3 CA10 UNC5D	7.94e-06	176	69	5	5daaba0853afe7d20d4635169ccd4f96e735b938
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR2 LRRN4CL ABCA6 KCNC4 MRC2	1.15e-05	190	69	5	f61e21d53f2f7804ac6e40ab6c7f69838aa94d6a
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THSD7A ADAMTS6 CLEC1A CHN1 SMAD7	1.15e-05	190	69	5	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	CMKLR2 FN1 LRRN4CL KCNC2 MRC2	1.15e-05	190	69	5	d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	CMKLR2 FN1 LRRN4CL KCNC2 MRC2	1.18e-05	191	69	5	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	10x5'-Lung-Myeloid_Dendritic-DC2\|Lung / Manually curated celltypes from each tissue	ABCA6 RASA4 MRC2 RNASET2 CLEC10A	1.24e-05	193	69	5	c97f9b13057f803df63c696c6175ef8e0aba6fa7
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THSD7A ADAMTS6 CLEC1A ATP13A3 SMAD7	1.34e-05	196	69	5	cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-B_(Artery)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	THSD7A FN1 MRC2 ATP13A3 SMAD7	1.34e-05	196	69	5	f540cf17b4405a6dd38d2b6123e6541d0aac889e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRE FN1 ADAMTS6 CLEC1A CHN1	1.34e-05	196	69	5	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRE FN1 ADAMTS6 CLEC1A CHN1	1.34e-05	196	69	5	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	3'-Broncho-tracheal-Immune_Myeloid\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRE RNASET2 CFP ATP13A3 CLEC10A	1.37e-05	197	69	5	d568354aff89ac84dd06360f19100ef578a041ed
ToppCell	(0)_Normal/No_Treatment-(4)_COL2.3+_osteoblasts\|World / Stress and Cell class	FN1 MRC2 RNASET2 CHN1	8.02e-05	147	69	4	87c24843cb0e87ad42e725d08423131a5d2d25a3
ToppCell	VE-CD8-antiviral_CD4\|VE / Condition, Cell_class and T cell subcluster	CMKLR2 PARP11 ABCA6 RASA4B	8.23e-05	148	69	4	f49f579650b57cc4c6c7a7fa726447740d3dc695
ToppCell	droplet-Fat-Scat-21m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRE FN1 CFP CLEC10A	8.67e-05	150	69	4	b6e5e04aaf1c5265ac07581868d3159f9292a84c
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|356C / Donor, Lineage, Cell class and subclass (all cells)	ALKBH1 KDM8 TRBC2 SENP7	8.90e-05	151	69	4	14c6f5d7441083861077b7362e6867d820aef864
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	PARP1 PSME4 UNC5D PRLR	9.13e-05	152	69	4	6f9c343669883618cd9c1c8921a90c34d153f303
ToppCell	remission-unassigned\|remission / disease stage, cell group and cell class	ALKBH1 NPR2 CXCR6 CLEC1A	9.60e-05	154	69	4	4130769829b838cc8a075c87ff6c187f0f507f8b
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PARP1 CXCR6 TNS4 TRBC2	9.60e-05	154	69	4	d0a1ff02a7e91f6923aa85b65094f78e357e377d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ALKBH1 PRSS8 KCNC2 CXCR6	9.84e-05	155	69	4	93f21b09f6f7755991d67886361b1c42a50fbbfc
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PARP1 CXCR6 TRBC2 UNC5D	9.84e-05	155	69	4	5687416773809b8c478567bc54310af102b3029a
ToppCell	remission-unassigned\|World / disease stage, cell group and cell class	ALKBH1 NPR2 CXCR6 CLEC1A	9.84e-05	155	69	4	d81bec894381e3e2d6249a567e8108b8423e5c54
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIAA0319 ALKBH1 RNASET2 APC	1.01e-04	156	69	4	f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCell	droplet-Fat-Scat-21m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRE FN1 CFP CLEC10A	1.06e-04	158	69	4	c8df636412a08c570f235c34d4cff46924a9b11d
ToppCell	droplet-Fat-Scat-21m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRE FN1 CFP CLEC10A	1.06e-04	158	69	4	718eafcf8a171bb69b402dc9d69564c3521a62a9
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-CD4_TEM\|ICU-NoSEP / Disease, Lineage and Cell Type	NPR2 TNS4 TRBC2 IMPG2	1.06e-04	158	69	4	8616b308d5c1a1042b23a9aaca971029ba732eb8
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRE ABCA6 CFP CLEC10A	1.09e-04	159	69	4	3bab00f8fb7d9232538e50f83dd0fd70ddd16819
ToppCell	metastatic_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|metastatic_Brain / Location, Cell class and cell subclass	DPYSL5 RASA4B TRBC2 CHN1	1.11e-04	160	69	4	bc86c6ba1b7815ab944e1ec9da703f469373b8b1
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FN1 CFP ATP13A3 CLEC10A	1.11e-04	160	69	4	6ed37d1fd0304932319d6b942502404115ff36a7
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRE ABCA6 CFP CLEC10A	1.11e-04	160	69	4	5bec867def73fa8531f8dad611679f4b44f573bd
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CMKLR2 PRSS8 ILDR1 SLC17A6	1.14e-04	161	69	4	66554f59eaea4ba55a6c6724f9368e24e99c91e9
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPRE LRRN4CL MROH2A	1.22e-04	164	69	4	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPRE LRRN4CL MROH2A	1.22e-04	164	69	4	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPRE LRRN4CL MROH2A	1.22e-04	164	69	4	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CELSR1 PTPRE LRRN4CL MROH2A	1.22e-04	164	69	4	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CXCR6 TRBC2 CHN1 IMPG2	1.25e-04	165	69	4	567c9f8fe29b5d34c2e39d9a17db54eba51ee559
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CXCR6 TRBC2 CHN1 IMPG2	1.25e-04	165	69	4	cdc05f4a3c2c301f537ae641314875e5ecc16510
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 KCNC2 CHN1 SLC17A6	1.25e-04	165	69	4	6d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CXCR6 TRBC2 CHN1 IMPG2	1.25e-04	165	69	4	2ebabe6fdbcf8765bcf9d98faf20da783c9d113d
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 KCNC2 CHN1 SLC17A6	1.25e-04	165	69	4	02cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PARP1 CXCR6 TNS4 TRBC2	1.31e-04	167	69	4	53e32d6687a07f486141df9f4ab998af4c03a507
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	THSD7A ADAMTS6 CLEC1A CHN1	1.34e-04	168	69	4	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD7A LRRN4CL ABCA6 MRC2	1.37e-04	169	69	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	facs-Heart-LA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 PRSS8 TMPRSS4 ILDR1	1.37e-04	169	69	4	421fb287c7e439d1870b7950c5e3ca34106e014a
ToppCell	facs-Heart-LA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 PRSS8 TMPRSS4 ILDR1	1.37e-04	169	69	4	383639ec4f9d0c6255e0881edca15cdd1980a37c
ToppCell	ASK428-Epithelial-Secretory\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	ALKBH1 NYNRIN TMPRSS4 TNS4	1.40e-04	170	69	4	9e275c4a70f9866f770fbdb0fe14a577287fe290
ToppCell	normal_Lung-T/NK_cells-Exhausted_Tfh\|normal_Lung / Location, Cell class and cell subclass	CXCR6 TNS4 TRBC2 CHN1	1.50e-04	173	69	4	e8ead6c51c41dbd43c717ba9d1a7a0ab39c79330
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	NEMP1 DNAJC10 NSD2 ILDR1	1.50e-04	173	69	4	67f0f0bf88eab69987b71d96b864ed2b14975adb
ToppCell	droplet-Marrow-nan-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 ABCA6 TNS4 CLEC10A	1.50e-04	173	69	4	6d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPRE NSD2 TNS4 THSD7B	1.54e-04	174	69	4	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	Healthy_donor-Treg\|Healthy_donor / disease group, cell group and cell class (v2)	CXCR6 ACR TRBC2 CHN1	1.54e-04	174	69	4	1d76921c8404b5be5fbe9f3157d53578033f2ad2
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN4CL KCNC4 CHN1 CSMD3	1.57e-04	175	69	4	59249c9e83952d7277010e7be3c779e26399eb5d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN4CL KCNC4 CHN1 CSMD3	1.57e-04	175	69	4	b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD7A LRRN4CL ABCA6 MRC2	1.60e-04	176	69	4	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	(00)_Basal-(2)_48hpi\|(00)_Basal / shred by cell type and Timepoint	FAM120A ACSS1 TMPRSS4 MINDY1	1.60e-04	176	69	4	0f6770296d7fa453ffbf6ca6d5fdebc888f6eb60
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD7A LRRN4CL ABCA6 MRC2	1.60e-04	176	69	4	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	Dendritic_Cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ABCA6 RASA4 CFP CLEC10A	1.64e-04	177	69	4	d2cd081bdda0eba9f6f6473c4d3939e4bee3440e
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_Tem\|Control / Disease, condition lineage and cell class	LRRN4CL CXCR6 TRBC2 CHN1	1.64e-04	177	69	4	3fba0c5edf816ce7f3c2af424f46c83477528878
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD7A ADAMTS6 CLEC1A SMAD7	1.64e-04	177	69	4	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	wk_20-22-Hematologic-Myeloid-pre-pDC/DC5\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PTPRE RASA4 CFP CLEC10A	1.64e-04	177	69	4	6de3c623f8595d7e3827df99b806bc9f1f15b3b7
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRE RNASET2 CFP CLEC10A	1.68e-04	178	69	4	8184a2b9872f7ca12a9823535de485e841aeffb1
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAJC10 ADAMTS6 CXCR6 TRBC2	1.68e-04	178	69	4	f94e306b9550f3d1b5de0bb806790c17823d439e
ToppCell	10x3'2.3-week_17-19-Lymphocytic_T-T_NK-NK_T_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CELSR1 CXCR6 RASA4B TRBC2	1.68e-04	178	69	4	a34bb693b72684cbd97ac9efff77d2d14e41be75
ToppCell	Mild-Lymphoid-T-innate_T\|Mild / Condition, Lineage, Cell class and cell subclass	CXCR6 TRBC2 CHN1 CA10	1.71e-04	179	69	4	abc0fbe101a464a2c85755a974a3d5c2b968fe46
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMKLR2 PTPRE ADAMTS6 CHN1	1.71e-04	179	69	4	ec1d7017da325647b629de703135a404bbdc627d
ToppCell	facs-Pancreas-Exocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 MROH2A CSMD3 AQP2	1.75e-04	180	69	4	72310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCell	NS-critical-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PARP1 THSD7A ILDR1 PRLR	1.79e-04	181	69	4	cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPR2 LRRN4CL ACSS1 ATP13A3	1.79e-04	181	69	4	41969fe4d94ee77b12ecde32170aaf0b13e49644
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPR2 LRRN4CL ACSS1 ATP13A3	1.79e-04	181	69	4	3f50e61dc2a52d71a5801584617607e6246adcf2
ToppCell	Control-Classical_Monocyte-cMono_4\|Control / Disease condition and Cell class	PTPRE FN1 ATP13A3 SMAD7	1.79e-04	181	69	4	f3e1d8fe5cf1eba19e51c3680a55306cae687fe9
ToppCell	facs-Marrow-T-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 SGPL1 ATP13A3 CLEC10A	1.79e-04	181	69	4	7286700396676fdc41d9723979b8b408177aceb9
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A PTPRE ADAMTS6 THSD7B	1.82e-04	182	69	4	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 LRRN4CL ABCA6 MRC2	1.82e-04	182	69	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CMKLR2 LRRN4CL ABCA6 MRC2	1.82e-04	182	69	4	d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KCNC4 ACSS1 ATP13A3 CHN1	1.86e-04	183	69	4	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS8 THSD7A ADAMTS6 THSD7B	1.86e-04	183	69	4	6e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS8 THSD7A ADAMTS6 THSD7B	1.86e-04	183	69	4	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KCNC4 ACSS1 ATP13A3 CHN1	1.86e-04	183	69	4	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-CD5+_CCL22+_mature_B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ADAMTS6 RASA4 RASA4B TRBC2	1.90e-04	184	69	4	5bb775253a10a14360b06a46aba46d162a9bd1f8
ToppCell	normal_Lymph_Node-Myeloid_cells-Monocytes\|normal_Lymph_Node / Location, Cell class and cell subclass	PTPRE CFP CLEC10A PRLR	1.90e-04	184	69	4	3cec28ff076fa53d034428de2bb1a237e0c1568c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A PTPRE ADAMTS6 THSD7B	1.90e-04	184	69	4	32473dbdb2de66391157c5814ef34e790806e4f2
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 LRRN4CL ABCA6 MRC2	1.94e-04	185	69	4	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 LRRN4CL ABCA6 MRC2	1.94e-04	185	69	4	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 LRRN4CL ABCA6 MRC2	1.94e-04	185	69	4	a94694e226856bc5b168464f52d76004145717a5
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RNASET2 TRBC2 CHN1 SENP7	1.94e-04	185	69	4	e34473eea3a58c041183a4f52137366cd9489495
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS8 THSD7A ADAMTS6 THSD7B	1.94e-04	185	69	4	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A PTPRE ADAMTS6 THSD7B	1.94e-04	185	69	4	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	THSD7A FN1 MRC2 ATP13A3	1.94e-04	185	69	4	b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	THSD7A FN1 MRC2 ATP13A3	1.94e-04	185	69	4	d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCell	E15.5-Epithelial-airway_epithelial_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRSS8 ACSS1 TMPRSS4 ILDR1	1.98e-04	186	69	4	bb2c7af3b1d8478c49a8626dbfd6c92c5e7adc4a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAJC10 ADAMTS6 CXCR6 TRBC2	1.98e-04	186	69	4	bbcd9062c0f6f65ca6f3cb101b6fa72ddd1e14fe
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD7A ADAMTS6 ATP13A3 SMAD7	1.98e-04	186	69	4	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	E15.5-Epithelial-airway_epithelial_cell-club_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRSS8 ACSS1 TMPRSS4 ILDR1	1.98e-04	186	69	4	86c809b99088d3d6c8f87785797c4beefdcddbe7
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-cDC2\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRE RNASET2 CFP CLEC10A	1.98e-04	186	69	4	44785bd171f424ad61437275026439fae3cb8d8c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHN1 CA10 UNC5D SLC17A6	1.98e-04	186	69	4	bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD7A KCNC2 ACR NYNRIN	1.98e-04	186	69	4	ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD7A KCNC2 ACR NYNRIN	1.98e-04	186	69	4	ed924852cd7132c8f6703522037dc22bd2c83193
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRE CFP ATP13A3 ACSS2	2.02e-04	187	69	4	3b1439018e265a61d9599e307a202e3c2f60ed32
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_naive\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRE CFP ATP13A3 ACSS2	2.02e-04	187	69	4	e99bc27d212c74da37770297122a4b30445ccd0d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS8 THSD7A ADAMTS6 THSD7B	2.02e-04	187	69	4	02105c82a9ba79d2f19e002188377fc3440770c2
Computational	Genes upregulated in subsets of cells of a given type within various tumors	THSD7A FN1 ADAMTS6 ATP13A3	6.38e-05	50	47	4	GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_NOTCH_SIGNALING
Drug	chrysobactin	ACR ACSS1 ACSS2	2.11e-06	9	68	3	CID000129039
Drug	propionyl-AMP	ACSS1 ACSS2	8.79e-06	2	68	2	CID000440863
Drug	APCP	NF1 APC	8.79e-06	2	68	2	CID003083759
Drug	Thimerosal	CCNT2 NF1 PSME4 FN1 SGPL1 NYNRIN RNASET2 FNBP4 APC CFP ATP13A3 CA10 PRLR SENP7	9.97e-06	1199	68	14	ctd:D013849
Drug	Mebendazole [31431-39-7]; Up 200; 13.6uM; MCF7; HT_HG-U133A	ATG5 CMKLR2 NF1 PTPRE ADAMTS7 TMPRSS4	2.16e-05	189	68	6	2300_UP
Drug	monomethyl phthalate	KIAA0319 PDIA6 NPR2 PRSS8 MRC2 SGPL1 ACR ACSS1 APC CFP KDM8 AQP2	2.35e-05	957	68	12	ctd:C517284
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	CMKLR2 FN1 SGPL1 NYNRIN ELP1 KDM8	2.57e-05	195	68	6	3393_DN
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CCNT2 NPR2 NF1 NYNRIN APC SENP7	2.65e-05	196	68	6	2291_DN
Drug	p-cymene	SGPL1 ACSS1 ACSS2	2.80e-05	20	68	3	CID000007463
Drug	Deltaline [6836-11-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A	NPR2 NF1 FN1 ADAMTS7 ACAN NYNRIN	2.80e-05	198	68	6	6026_UP
Drug	Acetohexamide [968-81-0]; Down 200; 12.4uM; MCF7; HT_HG-U133A	CCNT2 NF1 PTPRE FN1 TMPRSS4 PRLR	2.80e-05	198	68	6	7482_DN
Drug	Betahistine mesylate [54856-23-4]; Up 200; 17.2uM; PC3; HT_HG-U133A	NPR2 ACAN NYNRIN APC TMPRSS4 IMPG2	2.80e-05	198	68	6	6611_UP
Drug	Proglumide [6620-60-6]; Up 200; 12uM; HL60; HT_HG-U133A	CELSR1 NF1 FN1 CFP MINDY1 SENP7	2.88e-05	199	68	6	2363_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Up 200; 15uM; PC3; HT_HG-U133A	CELSR1 NF1 CXCR6 CLEC1A TMPRSS4 KDM8	2.88e-05	199	68	6	4259_UP
Drug	diethylamine NONOate	NPR2 KCNC2 KCNC4 ACR	6.42e-05	72	68	4	CID000107754
Drug	AC1Q6S45	ACSS1 APC ACSS2	7.08e-05	27	68	3	CID000000508
Drug	fludrocortisone	PRSS8 ACR ELP1 CLEC10A	7.94e-05	76	68	4	CID000031378
Drug	p-TMI	NF1 PRLR	1.31e-04	6	68	2	CID000017911
Drug	p-cumate	ACSS1 ACSS2	1.31e-04	6	68	2	CID000010820
Drug	5 fA	ACSS1 ACSS2	1.31e-04	6	68	2	CID000193491
Drug	GC-43	NF1 RASA4	1.83e-04	7	68	2	CID000043912
Drug	deoxyfuconojirimycin	MAN2B2 APC AQP2	1.84e-04	37	68	3	CID000122618
Drug	BAY 41-2272	NPR2 FN1 SLC17A6	1.84e-04	37	68	3	CID009798973
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A	PHKA2 NPR2 NF1 MINDY1 PRLR	2.20e-04	183	68	5	1668_UP
Drug	cytochalasin B; Down 200; 20.8uM; MCF7; HT_HG-U133A_EA	ATG5 PARP1 PSME4 RNASET2 SMAD7	2.43e-04	187	68	5	1122_DN
Drug	9-fluorenol	CHN1 CA10	2.43e-04	8	68	2	CID000074318
Drug	Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT_HG-U133A	PHKA2 NF1 PSME4 APC PRLR	2.74e-04	192	68	5	5509_DN
Drug	0317956-0000 [391210-11-0]; Down 200; 1uM; MCF7; HT_HG-U133A	NPR2 PTPRE APC ELP1 KDM8	2.74e-04	192	68	5	3858_DN
Drug	Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	NF1 CXCR6 NSD2 ACAN NYNRIN	2.74e-04	192	68	5	6512_UP
Drug	5230742; Down 200; 17uM; MCF7; HT_HG-U133A_EA	NF1 PSME4 NSD2 ATP13A3 SMAD7	2.74e-04	192	68	5	970_DN
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; HL60; HT_HG-U133A	CCNT2 NF1 APC KDM8 SENP7	2.81e-04	193	68	5	1873_DN
Drug	Trimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; PC3; HT_HG-U133A	APC ELP1 TMPRSS4 SENP7 SMAD7	2.81e-04	193	68	5	4202_DN
Drug	Carbachol [51-83-2]; Up 200; 21.8uM; MCF7; HT_HG-U133A	NPR2 MRC2 APC ELP1 PRLR	2.88e-04	194	68	5	5342_UP
Drug	Propantheline bromide [50-34-0]; Up 200; 9uM; MCF7; HT_HG-U133A	CMKLR2 NPR2 NF1 APC TMPRSS4	2.88e-04	194	68	5	4798_UP
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A	NF1 FN1 NYNRIN APC TMPRSS4	2.88e-04	194	68	5	3284_UP
Drug	Prednisone [53-03-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	CMKLR2 PARP1 NF1 ACAN KDM8	2.95e-04	195	68	5	4577_UP
Drug	Indomethacin [53-86-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A	CCNT2 ACAN APC KDM8 MINDY1	2.95e-04	195	68	5	5468_UP
Drug	5-aza-2′-deoxycytidine; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	CCNT2 NF1 APC TMPRSS4 CLEC10A	2.95e-04	195	68	5	920_UP
Drug	Imipramine hydrochloride [113-52-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A	NPR2 MRC2 ACAN CFP KDM8	2.95e-04	195	68	5	5440_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	NPR2 FN1 MRC2 ELP1 SENP7	2.95e-04	195	68	5	5241_DN
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; MCF7; HT_HG-U133A	PHKA2 NF1 FN1 PRLR SENP7	2.95e-04	195	68	5	5252_DN
Drug	Phensuximide [86-34-0]; Up 200; 21.2uM; PC3; HT_HG-U133A	NF1 MRC2 APC KDM8 CLEC10A	3.02e-04	196	68	5	5097_UP
Drug	Molindone hydrochloride [15622-65-8]; Up 200; 12.8uM; MCF7; HT_HG-U133A	NF1 APC ELP1 TMPRSS4 IMPG2	3.02e-04	196	68	5	4784_UP
Drug	Tinidazole [19387-91-8]; Up 200; 16.2uM; MCF7; HT_HG-U133A	NPR2 ACAN APC CFP IMPG2	3.02e-04	196	68	5	4370_UP
Drug	Fluorometholone [426-13-1]; Down 200; 10.6uM; MCF7; HT_HG-U133A	NF1 NSD2 MRC2 MINDY1 SMAD7	3.02e-04	196	68	5	6247_DN
Drug	N-Acetyl-L-leucine [1188-21-2]; Down 200; 23uM; MCF7; HT_HG-U133A	NF1 PTPRE SGPL1 KDM8 PRLR	3.02e-04	196	68	5	6462_DN
Drug	Amikacin hydrate [37517-28-5]; Up 200; 6.6uM; PC3; HT_HG-U133A	CMKLR2 FN1 CLEC1A CFP KDM8	3.02e-04	196	68	5	6715_UP
Drug	Spectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	FN1 CXCR6 CLEC1A TMPRSS4 KDM8	3.02e-04	196	68	5	4773_UP
Drug	Benoxinate hydrochloride [5987-82-6]; Up 200; 11.6uM; PC3; HT_HG-U133A	NF1 CLEC1A CFP CLEC10A PRLR	3.02e-04	196	68	5	3996_UP
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	PARP11 APC ELP1 TMPRSS4 PRLR	3.02e-04	196	68	5	987_UP
Drug	Meprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; PC3; HT_HG-U133A	CCNT2 NPR2 NF1 FN1 NSD2	3.02e-04	196	68	5	5723_DN
Drug	Benzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A	NF1 FN1 MRC2 CLEC1A APC	3.09e-04	197	68	5	3577_UP
Drug	Diflorasone Diacetate [33564-31-7]; Down 200; 8uM; MCF7; HT_HG-U133A	PHKA2 NF1 FN1 NYNRIN KDM8	3.09e-04	197	68	5	4158_DN
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	NF1 FN1 SGPL1 APC IMPG2	3.09e-04	197	68	5	5507_DN
Drug	Fluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A	NSD2 SGPL1 ATP13A3 KDM8 PRLR	3.09e-04	197	68	5	3370_DN
Drug	WY-14643; Up 200; 100uM; PC3; HG-U133A	CMKLR2 ACAN RNASET2 CLEC1A ATP13A3	3.09e-04	197	68	5	464_UP
Drug	Oxprenolol hydrochloride [6452-73-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A	PARP11 NF1 MRC2 CFP SLC17A6	3.09e-04	197	68	5	3568_UP
Drug	Phenformin hydrochloride [834-28-6]; Up 200; 16.6uM; HL60; HT_HG-U133A	PHKA2 NPR2 NF1 FN1 CFP	3.09e-04	197	68	5	2350_UP
Drug	Demecarium bromide [56-94-0]; Up 200; 5.6uM; MCF7; HT_HG-U133A	CCNT2 NF1 PTPRE APC CFP	3.09e-04	197	68	5	2773_UP
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; HL60; HT_HG-U133A	CCNT2 MRC2 APC MINDY1 SENP7	3.09e-04	197	68	5	2463_DN
Drug	Rimexolone [49697-38-3]; Up 200; 10.8uM; PC3; HT_HG-U133A	ADAMTS7 MRC2 TMPRSS4 TNS4 KDM8	3.09e-04	197	68	5	5092_UP
Drug	Guanethidine sulfate [60-02-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	CCNT2 APC ATP13A3 KDM8 PRLR	3.09e-04	197	68	5	3171_DN
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; PC3; HT_HG-U133A	CCNT2 NPR2 NF1 ACAN SENP7	3.09e-04	197	68	5	3784_DN
Drug	Mimosine [500-44-7]; Up 200; 20.2uM; PC3; HT_HG-U133A	FN1 NSD2 MRC2 APC MINDY1	3.09e-04	197	68	5	6703_UP
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; HL60; HT_HG-U133A	PHKA2 NEMP1 ALKBH1 NF1 ATP13A3	3.09e-04	197	68	5	1311_DN
Drug	KCC 009	PARP1 FN1	3.12e-04	9	68	2	ctd:C510621
Drug	pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	PARP1 FN1	3.12e-04	9	68	2	ctd:C077792
Drug	homohypotaurine	ACAN APC	3.12e-04	9	68	2	CID000193060
Drug	acetyl adenylate	ACSS1 ACSS2	3.12e-04	9	68	2	CID000440867
Drug	Sialic Acids	ATG5 PARP1	3.12e-04	9	68	2	ctd:D012794
Drug	cuminaldehyde	ACSS1 ACSS2	3.12e-04	9	68	2	CID000000326
Drug	Articaine hydrochloride [23964-57-0]; Up 200; 12.4uM; MCF7; HT_HG-U133A	CMKLR2 ADAMTS7 CXCR6 NSD2 CLEC10A	3.16e-04	198	68	5	6517_UP
Drug	S(-)-terguride hydrogen maleate [37686-85-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	NF1 PSME4 APC TMPRSS4 KDM8	3.16e-04	198	68	5	6473_DN
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; MCF7; HT_HG-U133A	CCNT2 NF1 NSD2 ATP13A3 PRLR	3.16e-04	198	68	5	4995_DN
Drug	Flutamide [13311-84-7]; Up 200; 14.4uM; PC3; HT_HG-U133A	NF1 APC MINDY1 PRLR IMPG2	3.16e-04	198	68	5	3803_UP
Drug	0173570-0000 [211245-44-2]; Up 200; 1uM; PC3; HT_HG-U133A	CCNT2 FN1 NYNRIN APC TMPRSS4	3.16e-04	198	68	5	7391_UP
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; PC3; HT_HG-U133A	PRSS8 NF1 NSD2 APC ELP1	3.16e-04	198	68	5	5102_UP
Drug	Enoxacin [74011-58-8]; Up 200; 12.4uM; PC3; HT_HG-U133A	ADAMTS7 MRC2 ACAN APC MINDY1	3.16e-04	198	68	5	4655_UP
Drug	Chlorambucil [305-03-3]; Up 200; 13.2uM; PC3; HT_HG-U133A	NF1 ABCA6 APC PRLR IMPG2	3.16e-04	198	68	5	3788_UP
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; PC3; HT_HG-U133A	KIAA0319 NF1 ACAN APC PRLR	3.16e-04	198	68	5	3810_UP
Drug	Betaxolol hydrochloride [63659-19-8]; Up 200; 11.6uM; PC3; HT_HG-U133A	CXCR6 ACAN CFP MINDY1 SENP7	3.16e-04	198	68	5	4608_UP
Drug	Merbromin [129-16-8]; Up 200; 5uM; PC3; HT_HG-U133A	NPR2 PTPRE CXCR6 MRC2 APC	3.16e-04	198	68	5	7398_UP
Drug	Ketotifen fumarate [34580-14-8]; Up 200; 9.4uM; PC3; HT_HG-U133A	CCNT2 NF1 PTPRE SGPL1 SMAD7	3.24e-04	199	68	5	5842_UP
Drug	aspirin, USP; Up 200; 100uM; HL60; HT_HG-U133A	PRSS8 NF1 MRC2 CLEC1A SLC17A6	3.24e-04	199	68	5	6164_UP
Drug	Leucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A	NF1 FN1 MRC2 CFP IMPG2	3.24e-04	199	68	5	3546_UP
Drug	Phenethicillin potassium salt [132-93-4]; Up 200; 10uM; MCF7; HT_HG-U133A	NF1 THSD7A ADAMTS7 CXCR6 ACAN	3.24e-04	199	68	5	6105_UP
Drug	Cefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A	NF1 FN1 CXCR6 CFP IMPG2	3.24e-04	199	68	5	2235_UP
Drug	Corynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; PC3; HT_HG-U133A	NPR2 NF1 ADAMTS7 MINDY1 PRLR	3.31e-04	200	68	5	4227_UP
Drug	Alprenolol hydrochloride [13707-88-5]; Down 200; 14uM; MCF7; HT_HG-U133A	CCNT2 NF1 FN1 APC SMAD7	3.31e-04	200	68	5	6789_DN
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A	NF1 ACAN NYNRIN APC CFP	3.31e-04	200	68	5	3795_UP
Drug	Chloroquine	ATG5 PARP1 AQP2 PRLR	3.43e-04	111	68	4	ctd:D002738
Disease	Colorectal Carcinoma	ATG5 PARP1 NF1 FN1 ABCA6 APC TNS4 CSMD3 SMAD7	3.27e-05	702	68	9	C0009402
Disease	level of lactase/phlorizin hydrolase in blood serum	CCNT2 THSD7B	7.80e-05	6	68	2	OBA_2042177
Disease	achondroplasia (implicated_via_orthology)	NPR2 ACAN	7.80e-05	6	68	2	DOID:4480 (implicated_via_orthology)
Disease	Lymphopenia	ATG5 SGPL1	1.09e-04	7	68	2	C0024312
Disease	medulloblastoma (is_implicated_in)	APC ELP1	2.33e-04	10	68	2	DOID:0050902 (is_implicated_in)
Disease	Animal Mammary Neoplasms	FN1 MRC2 APC PRLR	3.30e-04	142	68	4	C0024667
Disease	Mammary Carcinoma, Animal	FN1 MRC2 APC PRLR	3.30e-04	142	68	4	C1257925
Disease	cognitive function measurement	ATG5 PDIA6 FAM120A THSD7A KCNC2 KCNC4 DPYSL5 THSD7B CSMD3 CA10 PRLR	4.11e-04	1434	68	11	EFO_0008354
Disease	alcohol consumption measurement	NF1 THSD7A KCNC2 ACSS1 DPYSL5 FNBP4 THSD7B CSMD3 SENP7 IMPG2	5.31e-04	1242	68	10	EFO_0007878
Disease	Glioblastoma	NF1 FN1 APC	8.17e-04	79	68	3	C0017636
Disease	IGF-1 measurement	PRSS8 FAM120A DPYSL5 ELP1 PRLR SENP7	9.13e-04	488	68	6	EFO_0004627
Disease	Alveolitis, Fibrosing	PARP1 FN1 SMAD7	9.43e-04	83	68	3	C4721507
Disease	acetate measurement	ACSS1 ACSS2	9.68e-04	20	68	2	EFO_0010112
Disease	Giant Cell Glioblastoma	NF1 FN1 APC	9.76e-04	84	68	3	C0334588
Disease	Pulmonary Fibrosis	PARP1 FN1 SMAD7	1.01e-03	85	68	3	C0034069
Disease	Antiglaucoma preparations and miotics use measurement	THSD7A FNBP4	1.64e-03	26	68	2	EFO_0009944
Disease	taste liking measurement	CMKLR2 PARP1 THSD7A THSD7B CSMD3	2.03e-03	388	68	5	EFO_0010155
Disease	Developmental Academic Disorder	NF1 SLC17A6	2.04e-03	29	68	2	C1330966
Disease	Learning Disorders	NF1 SLC17A6	2.04e-03	29	68	2	C0023186
Disease	Learning Disturbance	NF1 SLC17A6	2.04e-03	29	68	2	C0751263
Disease	Adult Learning Disorders	NF1 SLC17A6	2.04e-03	29	68	2	C0751262
Disease	Learning Disabilities	NF1 SLC17A6	2.04e-03	29	68	2	C0751265
Disease	Glioblastoma Multiforme	NF1 FN1 APC	2.17e-03	111	68	3	C1621958
Disease	free cholesterol measurement	ABCA6 NYNRIN FNBP4	2.29e-03	113	68	3	EFO_0008591

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVWDTPYHTVWDCDF	ACSS1	81	Q9NUB1
PAVVTGKFDDHWVFW	AQP2	191	P41181
IPVSTDGKHWWEYVD	CCNT2	211	O60583
DGKHWWEYVDPTVTL	CCNT2	216	O60583
VCTLPFWAYAGIHEW	CXCR6	81	O00574
WPGYYKDSLNCEWVI	CSMD3	911	Q7Z407
FLPGYQWHWVKQCLK	ALKBH1	106	Q13686
SCWVAGWGYIEEKAP	ACR	176	P10323
QPWYEVWHPKSDACN	ATP13A3	1031	Q9H7F0
PLWKEDFSAHCWDGY	ABCA6	146	Q8N139
QPAAHYSGAEKQIWW	NPR2	406	P20594
IYNGCPKAFEAGIWW	CELSR1	2051	Q9NYQ6
FWGDIAKEFYWKTPC	ACSS2	61	Q9NR19
SEIWFEYEGTPLKWH	ATG5	66	Q9H1Y0
FTVEYWGKDGPQWKH	ADAMTS6	111	Q9UKP5
PVFSWHYGPWTKCTV	ADAMTS7	821	Q9UKP4
WKTLCPFWGEEYQVH	RASA4	46	O43374
WKTLCPFWGEEYQVH	RASA4B	46	C9J798
GKVPHWYHFSCFWKV	PARP1	46	P09874
EEKCHQYWPDQGCWT	PTPRE	241	P23469
PCLEYHNNTWTWLDF	KIAA0100	2146	Q14667
SEHTQFKNIPIGFWW	KCNC2	416	Q96PR1
VVHWCAPFSPVLHYW	LRRN4CL	101	Q8ND94
VADHWPCMQKWSLEY	KDM8	211	Q8N371
FCYTNVLIPKWHDIW	NEMP1	66	O14524
VKLGNYRWWPAEVCH	NSD2	886	O96028
MWWDHGVYYCTIEAP	ILDR1	136	Q86SU0
DWYNSGKPCVFWLSG	DNAH12	2931	Q6ZR08
PDFYCVKWIPWKGEQ	MINDY1	111	Q8N5J2
TWHSPSCYWLGEDQV	MRC2	526	Q9UBG0
PKTCVQLWTVGNYHW	ELP1	316	O95163
IPWEHCCPWMYFDGK	FAM120A	791	Q9NZB2
YSIQHCPLKGSWSEW	CFP	371	P27918
WHEKGEWNDVPCNYH	ACAN	2421	P16112
WFYLAECGKWHMFQP	PARP11	36	Q9NR21
WCHDNGVNYKIGEKW	FN1	2341	P02751
HVLWPWGCDKQFFNA	MAN2B2	281	Q9Y2E5
NEVWMVDFYSPWCHP	DNAJC10	576	Q8IXB1
QGKNHWVIDFYAPWC	DNAJC10	686	Q8IXB1
PHWCEYCANFMWGLI	CHN1	216	P15882
PKIHEGWWAYKEVVQ	CA10	26	Q9NS85
CDYALHVGITWWAPK	DPYSL5	126	Q9BPU6
CEWPVFWTYFIIDGV	PHKA2	326	P46019
WMVEFYAPWCGHCKN	PDIA6	181	Q15084
WWPGMQEHVKDYCRS	NYNRIN	1571	Q9P2P1
FQCVHFWGWKSLEHP	MROH2A	1541	A6NES4
NESSHWYLAVICFPW	SENP7	856	Q9BQF6
VYHWQTGPWGQCIED	THSD7A	696	Q9UPZ6
QYEINATPKGWSCHW	FNBP4	591	Q8N3X1
VGENWWYRGKHCEEF	IMPG2	1081	Q9BZV3
WPWQVSITYEGVHVC	PRSS8	56	Q16651
NGHCTKYEPWQLIAW	SGPL1	31	O95470
YCETCWEWQEAHEPG	APC	416	P25054
FHWPFGIWLCKANSF	CMKLR2	101	P46091
CPVNWVEHQDSCYWF	CLEC10A	181	Q8IUN9
PCTEQWKWHGDNCYQ	CLEC1A	136	Q8NC01
GWVPVEKNNKQYCWH	C12orf29	141	Q8N999
DDIWLVDFYAPWCGH	TMX3	41	Q96JJ7
YWTIHGLWPDKSEGC	RNASET2	61	O00584
EGVTYPACHGIWSKW	SLC17A6	191	Q9P2U8
GDRSHWCVVAYWEEK	SMAD7	256	O15105
WQKYCKPSWIFGFVA	TNS4	661	Q8IZW8
VRCKPDHGYWSAWSP	PRLR	206	P16471
WPWQVSIQYDKQHVC	TMPRSS4	216	Q9NRS4
SALDWWPKIDAVYCH	NF1	421	P21359
FHGPEDYWCQCVAWS	UNC5D	126	Q6UXZ4
SCFVEKTHWGYYTWP	PSME4	1266	Q14997
YPDHVELSWWVNGKE	TRBC2	36	A0A5B9
AIENNKYGWFWVCPG	ZC3H15	186	Q8WU90
WEVSDWHHCVLVPYA	THSD7B	106	Q9C0I4
DHTDFKNIPIGFWWA	KCNC4	416	Q03721
WWFEGRCYLVSCPHK	KIAA0319	71	Q5VV43
KPDCNYHNEEDVSWW	NLRP14	1076	Q86W24