Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontemperature-gated ion channel activity

TRPV1 KCNK4

1.05e-0431192GO:0097603
GeneOntologyMolecularFunctionCoA carboxylase activity

ACACB MCCC1

5.20e-0461192GO:0016421
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5B KDM5A

5.20e-0461192GO:0034647
GeneOntologyMolecularFunctionbiotin binding

ACACB MCCC1

5.20e-0461192GO:0009374
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5B KDM5A KDM4A

6.06e-04281193GO:0141052
GeneOntologyMolecularFunctiontransition metal ion binding

KDM5B KDM5A CYP4A11 DTNB CYP11B2 ENPP3 POLR2K LANCL1 TRIM39 TRIM29 MTPAP ESCO1 ADAMTS9 ADAMTS20 KDM4A MUC2 RABGGTA

6.80e-04118911917GO:0046914
GeneOntologyMolecularFunctionligase activity, forming carbon-carbon bonds

ACACB MCCC1

7.25e-0471192GO:0016885
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5B KDM5A KDM4A

8.21e-04311193GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5B KDM5A KDM4A

9.02e-04321193GO:0140457
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5B KDM5A

9.63e-0481192GO:0032453
GeneOntologyCellularComponentmucus layer

MUC2 MUC5AC

9.93e-0531212GO:0070701
DomainJmjN

KDM5B KDM5A KDM4A

2.78e-05101173SM00545
DomainJmjN

KDM5B KDM5A KDM4A

2.78e-05101173PF02375
DomainJMJN

KDM5B KDM5A KDM4A

2.78e-05101173PS51183
DomainJmjN

KDM5B KDM5A KDM4A

2.78e-05101173IPR003349
DomainPept_M12B_GON-ADAMTSs

ADAMTS9 ADAMTS20

3.89e-0521172IPR012314
DomainGON

ADAMTS9 ADAMTS20

3.89e-0521172PS51046
DomainGON

ADAMTS9 ADAMTS20

3.89e-0521172PF08685
DomainC8

FCGBP MUC2 MUC5AC

5.06e-05121173PF08742
DomainTIL

FCGBP MUC2 MUC5AC

5.06e-05121173PF01826
DomainUnchr_dom_Cys-rich

FCGBP MUC2 MUC5AC

6.55e-05131173IPR014853
DomainC8

FCGBP MUC2 MUC5AC

6.55e-05131173SM00832
DomainTIL_dom

FCGBP MUC2 MUC5AC

8.29e-05141173IPR002919
DomainVWC

FCGBP CHRD MUC2 MUC5AC

9.16e-05381174SM00214
DomainVWF_type-D

FCGBP MUC2 MUC5AC

1.26e-04161173IPR001846
DomainVWFD

FCGBP MUC2 MUC5AC

1.26e-04161173PS51233
DomainVWD

FCGBP MUC2 MUC5AC

1.26e-04161173SM00216
DomainVWD

FCGBP MUC2 MUC5AC

1.26e-04161173PF00094
DomainVWF_dom

FCGBP CHRD MUC2 MUC5AC

1.36e-04421174IPR001007
DomainVWC_out

FCGBP MUC2 MUC5AC

2.16e-04191173SM00215
DomainLys_sp_deMease-like_dom

KDM5B KDM5A

2.32e-0441172IPR013637
DomainPLU-1

KDM5B KDM5A

2.32e-0441172PF08429
DomainBiotin_BS

ACACB MCCC1

3.84e-0451172IPR001882
DomainBiotin_COase_C

ACACB MCCC1

3.84e-0451172IPR005482
DomainBC

ACACB MCCC1

3.84e-0451172PS50979
Domainzf-C5HC2

KDM5B KDM5A

3.84e-0451172PF02928
DomainBiotin_carb_C

ACACB MCCC1

3.84e-0451172SM00878
DomainBiotin_carb_C

ACACB MCCC1

3.84e-0451172PF02785
DomainBiotin_carboxylation_dom

ACACB MCCC1

3.84e-0451172IPR011764
DomainZnf_C5HC2

KDM5B KDM5A

3.84e-0451172IPR004198
DomainBIOTIN

ACACB MCCC1

3.84e-0451172PS00188
DomainJmjC

KDM5B KDM5A KDM4A

4.41e-04241173PF02373
DomainPeptidase_M12B_ADAM-TS

ADAMTSL1 ADAMTS9 ADAMTS20

4.41e-04241173IPR013273
DomainRudment_hybrid_motif

ACACB MCCC1

5.74e-0461172IPR011054
DomainCPSASE_2

ACACB MCCC1

5.74e-0461172PS00867
DomainWxxW_domain

MUC2 MUC5AC

5.74e-0461172IPR025155
DomainMucin2_WxxW

MUC2 MUC5AC

5.74e-0461172PF13330
DomainCbamoylP_synth_lsu-like_ATP-bd

ACACB MCCC1

8.00e-0471172IPR005479
DomainBC-like_N

ACACB MCCC1

8.00e-0471172IPR005481
DomainCPSase_L_D2

ACACB MCCC1

8.00e-0471172PF02786
DomainBiotin_carb_N

ACACB MCCC1

8.00e-0471172PF00289
DomainJMJC

KDM5B KDM5A KDM4A

1.04e-03321173PS51184
DomainJmjC_dom

KDM5B KDM5A KDM4A

1.04e-03321173IPR003347
DomainJmjC

KDM5B KDM5A KDM4A

1.14e-03331173SM00558
DomainPI3Ka

PIK3CA PI4KA

1.36e-0391172PF00613
DomainPI3Ka

PIK3CA PI4KA

1.36e-0391172SM00145
DomainBiotin_lipoyl

ACACB MCCC1

1.36e-0391172PF00364
Domain-

PIK3CA PI4KA

1.36e-03911721.25.40.70
DomainPH_dom-like

RGPD2 RANBP2 NET1 DGKH CDC42BPB TYK2 ELMO2 ARHGEF26 ARAP2

1.45e-034261179IPR011993
DomainVWFC_1

CHRD MUC2 MUC5AC

1.47e-03361173PS01208
DomainPI_Kinase

PIK3CA PI4KA

1.69e-03101172IPR015433
DomainBIOTINYL_LIPOYL

ACACB MCCC1

1.69e-03101172PS50968
DomainPInositide-3_kin_accessory_dom

PIK3CA PI4KA

1.69e-03101172IPR001263
DomainPIK_HELICAL

PIK3CA PI4KA

1.69e-03101172PS51545
DomainBiotin_lipoyl

ACACB MCCC1

1.69e-03101172IPR000089
DomainVWFC_2

CHRD MUC2 MUC5AC

1.72e-03381173PS50184
DomainPHD

KDM5B KDM5A BAZ2A KDM4A

2.37e-03891174SM00249
DomainRan_BP1

RGPD2 RANBP2

2.46e-03121172PF00638
DomainRANBD1

RGPD2 RANBP2

2.46e-03121172PS50196
DomainSingle_hybrid_motif

ACACB MCCC1

2.46e-03121172IPR011053
DomainZnf_PHD

KDM5B KDM5A BAZ2A KDM4A

2.57e-03911174IPR001965
DomainRanBD

RGPD2 RANBP2

2.90e-03131172SM00160
DomainRan_bind_dom

RGPD2 RANBP2

2.90e-03131172IPR000156
Domain-

ACACB MCCC1

2.90e-031311723.40.50.20
DomainZF_PHD_2

KDM5B KDM5A BAZ2A KDM4A

3.00e-03951174PS50016
DomainZF_PHD_1

KDM5B KDM5A BAZ2A KDM4A

3.12e-03961174PS01359
Domain-

RGPD2 RANBP2 NET1 DGKH CDC42BPB ELMO2 ARHGEF26 ARAP2

3.23e-0339111782.30.29.30
DomainATP_GRASP

ACACB MCCC1

3.37e-03141172PS50975
DomainPLAC

PCSK5 ADAMTSL1

3.37e-03141172PF08686
DomainATP-grasp

ACACB MCCC1

3.37e-03141172IPR011761
DomainPreATP-grasp_dom

ACACB MCCC1

3.37e-03141172IPR016185
Domain-

KDM5B KDM5A

3.87e-031511721.10.150.60
DomainBRIGHT

KDM5B KDM5A

3.87e-03151172SM00501
DomainARID_dom

KDM5B KDM5A

3.87e-03151172IPR001606
DomainARID

KDM5B KDM5A

3.87e-03151172PS51011
DomainPI3/4_kinase_CS

PIK3CA PI4KA

3.87e-03151172IPR018936
DomainARID

KDM5B KDM5A

3.87e-03151172PF01388
Domain-

ACACB MCCC1

3.87e-031511723.30.1490.20
Domain-

PIK3CA PI4KA

4.41e-031611721.10.1070.11
DomainPI3Kc

PIK3CA PI4KA

4.41e-03161172SM00146
DomainATP_grasp_subdomain_1

ACACB MCCC1

5.58e-03181172IPR013815
DomainPI3_PI4_kinase

PIK3CA PI4KA

5.58e-03181172PF00454
DomainCTCK_1

MUC2 MUC5AC

5.58e-03181172PS01185
DomainPI3_4_KINASE_1

PIK3CA PI4KA

5.58e-03181172PS00915
DomainPI3_4_KINASE_2

PIK3CA PI4KA

5.58e-03181172PS00916
Domain-

ACACB MCCC1

5.58e-031811723.30.470.20
DomainPI3/4_kinase_cat_dom

PIK3CA PI4KA

5.58e-03181172IPR000403
DomainPI3_4_KINASE_3

PIK3CA PI4KA

5.58e-03181172PS50290
DomainPLAC

PCSK5 ADAMTSL1

6.21e-03191172PS50900
DomainPLAC

PCSK5 ADAMTSL1

6.21e-03191172IPR010909
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD2 RANBP2 CENPF KDM5A ASIC1 DNM1L GRM5 CDC42BPB LUZP1 EFTUD2 PI4KA CTNNA2 EML1 SCRIB CDC5L BRSK1 ARHGEF26

5.48e-089631231728671696
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KDM5B SH3RF1 NET1 KDM5A BACH1 BRSK2 DNM1L CEP192 MCCC1 LUZP1 GRIP1 ELMO2 PI4KA TNKS1BP1 SCRIB ARAP2

6.96e-088611231636931259
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD2 KDM5B RANBP2 ACACB CENPF KDM5A TPGS1 MCCC1 LUZP1 TNKS1BP1 HSPA6

3.06e-074181231134709266
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RNGTT MCPH1 CENPF RNASE12 DGKH ZBTB41 RBM28 MTPAP ESCO1 ADAMTS9 PI4KA CHRD SCRIB

2.23e-067361231329676528
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP36 RNGTT ACACB DNM1L CEP192 MCCC1 CDC42BPB EFTUD2 PI4KA SCRIB SDK1 NUP160 ARAP2

4.02e-067771231335844135
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

USP36 RANBP2 HIP1R LANCL1 MCCC1 RBM28 MTPAP LUZP1 EFTUD2 SMG8 BAZ2A PI4KA PDCD11 SCRIB CDC5L HSPA6 NUP160

5.88e-0613531231729467282
Pubmed

Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation.

DNM1L GFER

1.24e-052123228646508
Pubmed

Mucolytic activity of bacterial and human chitinases.

MUC2 MUC5AC

1.24e-052123217321686
Pubmed

Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.

MUC2 MUC5AC

1.24e-052123220731025
Pubmed

Genomic, Transcriptomic, Epigenetic, and Immune Profiling of Mucinous Breast Cancer.

PIK3CA MUC2

1.24e-052123230789657
Pubmed

The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.

FCGBP MUC2

1.24e-052123234126068
Pubmed

Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.

TRPV1 ASIC1

1.24e-052123212393854
Pubmed

Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.

MUC2 MUC5AC

1.24e-052123223832517
Pubmed

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.

MUC2 MUC5AC

1.24e-052123223832516
Pubmed

KDM5 lysine demethylases are involved in maintenance of 3'UTR length.

KDM5B KDM5A

1.24e-052123228138513
Pubmed

Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.

BRSK2 BRSK1

1.24e-052123230307479
Pubmed

Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.

MUC2 MUC5AC

1.24e-052123217203232
Pubmed

Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells.

DNM1L GFER

1.24e-052123220147447
Pubmed

Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons.

TRPV1 GRM5

1.24e-052123219675234
Pubmed

Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.

MUC2 MUC5AC

1.24e-052123212527922
Pubmed

A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells.

DNM1L GFER

1.24e-052123220581476
Pubmed

CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.

CENPF DNM1L

1.24e-052123236513638
Pubmed

Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.

FCGBP MUC2

1.24e-052123219432394
Pubmed

Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity.

TRPV1 GRM5

1.24e-052123225297838
Pubmed

Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.

TEX15 FANCD2

1.24e-052123228386063
Pubmed

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.

KDM5B KDM5A

1.24e-052123230472020
Pubmed

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

ADAMTS9 ADAMTS20

1.24e-052123212514189
Pubmed

Coexpression of vanilloid receptor subtype-1 and acid-sensing ion channel genes in the human trigeminal ganglion neurons.

TRPV1 ASIC1

1.24e-052123215738111
Pubmed

KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.

KDM5B KDM5A

1.24e-052123234184733
Pubmed

SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.

BRSK2 BRSK1

1.24e-052123216630837
Pubmed

In vivo glycosylation of mucin tandem repeats.

MUC2 MUC5AC

1.24e-052123211445551
Pubmed

Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis.

KDM5B KDM5A

1.24e-052123236509829
Pubmed

Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma.

MUC2 MUC5AC

1.24e-052123214594655
Pubmed

Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.

BRSK2 BRSK1

1.24e-052123218339622
Pubmed

Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide.

MUC2 MUC5AC

1.24e-052123212820724
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

USP36 RANBP2 MCPH1 CENPF KDM5A BACH1 POLR2K MCCC1 RBM28 ESCO1 EFTUD2 ZSCAN21 BAZ2A PDCD11 CDC5L HSPA6

1.38e-0512941231630804502
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

USP36 RANBP2 RNGTT MYO1D DTNB CEP192 CDC42BPB LUZP1 FANCD2 STXBP3 PI4KA SCRIB CDC5L HSPA6

2.16e-0510491231427880917
Pubmed

Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway.

PIK3CA MUC2

3.71e-053123220718712
Pubmed

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.

BRSK2 BRSK1

3.71e-053123222669945
Pubmed

Differences in the expression of mucins in various forms of cystitis glandularis.

MUC2 MUC5AC

3.71e-053123217659847
Pubmed

Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.

MUC2 MUC5AC

3.71e-053123218825309
Pubmed

Acid-induced pain and its modulation in humans.

TRPV1 ASIC1

3.71e-053123215574747
Pubmed

Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.

MUC2 MUC5AC

3.71e-053123218300795
Pubmed

Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast.

MUC2 MUC5AC

3.71e-053123217333267
Pubmed

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.

KDM5B KDM5A

3.71e-053123238230606
Pubmed

Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.

KDM5B KDM5A

3.71e-053123216645588
Pubmed

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1.

TRPV1 ASIC1

3.71e-053123233888605
Pubmed

Mucin gene polymorphisms in otitis media patients.

MUC2 MUC5AC

3.71e-053123219718741
Pubmed

Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.

BRSK2 BRSK1

3.71e-053123220026642
Pubmed

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.

ADAMTS9 ADAMTS20

3.71e-053123224753090
Pubmed

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

KDM5B KDM5A

3.71e-053123226645689
Pubmed

ASIC1a mediates the drug resistance of human hepatocellular carcinoma via the Ca2+/PI3-kinase/AKT signaling pathway.

ASIC1 PIK3CA

3.71e-053123227918554
Pubmed

Microtubule stabilization specifies initial neuronal polarization.

BRSK2 BRSK1

3.71e-053123218268107
Pubmed

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

KDM5B KDM4A

3.71e-053123227214403
Pubmed

Gene expression profiling of colorectal mucinous adenocarcinomas.

MUC2 MUC5AC

3.71e-053123220485009
Pubmed

Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.

ADAMTS9 ADAMTS20

3.71e-053123237169079
Pubmed

Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas.

MUC2 MUC5AC

3.71e-053123223464473
Pubmed

Meconium ileus in cystic fibrosis is not linked to central repetitive region length variation in MUC1, MUC2, and MUC5AC.

MUC2 MUC5AC

3.71e-053123224920497
Pubmed

TRIM29 promotes progression of thyroid carcinoma via activating P13K/AKT signaling pathway.

TRIM29 PIK3CA

3.71e-053123228098872
Pubmed

Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study.

MYO1D KDM4A

3.71e-053123222322875
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

RANBP2 MYO1D MCCC1 RBM28 EFTUD2 CDC5L NUP160

5.44e-05272123725315684
Pubmed

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

PCSK5 KDM4A ARAP2

5.48e-0521123322959728
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM5B KDM5A KDM4A

5.48e-0521123327626377
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

RANBP2 MYO1D MCCC1 RBM28 EFTUD2 STXBP3 PDCD11 SCRIB NUP160

5.89e-05484123931995728
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SH3RF1 BRSK2 CDC42BPB ESCO1 EFTUD2 ADAMTS9 MINAR1 CDC5L NUP160

6.78e-05493123915368895
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5B KDM5A

7.41e-054123216541399
Pubmed

Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors.

TRPV1 ASIC1

7.41e-054123234199609
Pubmed

Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.

MUC2 MUC5AC

7.41e-054123225638393
Pubmed

Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.

MUC2 MUC5AC

7.41e-054123222269464
Pubmed

Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.

MUC2 MUC5AC

7.41e-054123222691042
Pubmed

Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells.

MUC2 MUC5AC

7.41e-054123212391274
Pubmed

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.

MUC2 MUC5AC

7.41e-054123223807779
Pubmed

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.

KDM5B KDM5A

7.41e-054123222615382
Pubmed

Tuberous sclerosis complex proteins control axon formation.

BRSK2 BRSK1

7.41e-054123218794346
Pubmed

Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.

MUC2 MUC5AC

7.41e-054123233154304
Pubmed

Gastric mucin expression in first-degree relatives of gastric cancer patients.

MUC2 MUC5AC

7.41e-054123224901817
Pubmed

Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).

MUC2 MUC5AC

7.41e-054123236367122
Pubmed

Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.

FCGBP MUC2

7.41e-054123228604600
Pubmed

Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.

MUC2 MUC5AC

7.41e-054123217471237
Pubmed

The mouse secreted gel-forming mucin gene cluster.

MUC2 MUC5AC

7.41e-054123214984930
Pubmed

Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.

MUC2 MUC5AC

7.41e-054123229869461
Pubmed

[Expression and clinical significance of Mucin and E-cadherin in colorectal tumors].

MUC2 MUC5AC

7.41e-054123217991319
Pubmed

Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?

MUC2 MUC5AC

7.41e-054123220929551
Pubmed

MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance.

MUC2 MUC5AC

7.41e-054123227298226
Pubmed

PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation.

MUC2 MUC5AC

7.41e-054123223619266
Pubmed

Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury.

DNM1L GFER

7.41e-054123233110216
Pubmed

Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus.

MUC2 MUC5AC

7.41e-054123217401217
Pubmed

Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.

MUC2 MUC5AC

7.41e-054123212676567
Pubmed

Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in ovarian mucinous tumours: changes in expression from benign to malignant tumours.

MUC2 MUC5AC

7.41e-054123225298197
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

USP36 RANBP2 RNGTT GTPBP6 NET1 KDM5A HIP1R GON4L CDC42BPB MTPAP LUZP1 BAZ2A PI4KA PDCD11 CTNNA2 HSPA6

7.89e-0514971231631527615
Pubmed

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

NET1 DNM1L SCRIB

1.19e-0427123324550280
Pubmed

Polymorphism of human mucin genes in chest disease: possible significance of MUC2.

MUC2 MUC5AC

1.23e-045123211062147
Pubmed

Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14.

MUC2 MUC5AC

1.23e-045123212507512
Pubmed

ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.

ADAMTS9 ADAMTS20

1.23e-045123231600785
Pubmed

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.

MUC2 MUC5AC

1.23e-045123212135769
Pubmed

Differential expression of MUC genes in endometrial and cervical tissues and tumors.

MUC2 MUC5AC

1.23e-045123216188033
Pubmed

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

PIK3CA PI4KA

1.23e-04512328246987
Pubmed

MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer.

MUC2 MUC5AC

1.23e-045123216475027
Pubmed

Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

BRSK2 BRSK1

1.23e-045123215150265
Pubmed

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

BRSK2 BRSK1

1.23e-045123218854318
InteractionHDAC1 interactions

USP36 CCNL2 KDM5B RANBP2 ACACB CENPF KDM5A BACH1 GON4L TPGS1 MCCC1 ESCO1 LUZP1 EFTUD2 FANCD2 GRIP1 BAZ2A PIK3CA TNKS1BP1 KDM4A HSPA6

2.23e-06110812021int:HDAC1
InteractionNUP43 interactions

USP36 RANBP2 ACACB KDM5A GON4L CCDC168 RBM28 GFER FANCD2 BAZ2A PI4KA PDCD11 HSPA6 NUP160 PDZD2

4.66e-0662512015int:NUP43
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5B KDM5A KDM4A

1.70e-0424823485
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

RC3H2 NET1 KDM5A APOBR GRIP1 PIK3CA PI4KA

1.11e-06196121709d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 CD177 GRIP1 ADAMTS9 CHRD ADAMTS20

1.12e-0518412167f6c8912677764d438ab0555faca344d74c2f483
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GLIPR1 LANCL1 GRIP1 CHRD MINAR1 SDK1

1.31e-05189121699a13b1b669b0cd36e3096632351d9ade25d1173
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GLIPR1 BACH1 LANCL1 GRIP1 CHRD MINAR1

1.35e-0519012168c9c230a509afaeee50644153974a5642b01a2b8
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGPD2 RANBP2 SPAG1 HIP1R BAZ2A PIK3CA

1.39e-0519112161ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SIGLEC9 APOBR KCNK4 CD163 FCGBP HSPA6

1.75e-051991216514dbf128b6832b1cbd65be023d4fe02400e8dec
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

CD177 CENPF ZSCAN25 RBM28 APOBR ARAP2

1.80e-0520012166e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellSigmoid-T_cell-cycling_gd_T|Sigmoid / Region, Cell class and subclass

CD177 CENPF ZSCAN25 RBM28 APOBR ARAP2

1.80e-0520012169769185abae084ffac36420c749625e679b70ca8
Diseasecystitis (is_marker_for)

MUC2 MUC5AC

1.61e-0521192DOID:1679 (is_marker_for)
Diseaseamyotrophic lateral sclerosis, age at onset

PCSK5 KDM4A ARAP2

2.81e-05151193EFO_0004847, MONDO_0004976
Diseasesputum mucin-5B amount

MUC2 MUC5AC

4.83e-0531192OBA_2050332
Diseaseserine/threonine-protein kinase BRSK2 measurement

BRSK2 BRSK1

4.83e-0531192EFO_0803063
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5B KDM5A

9.63e-0541192DOID:0060809 (implicated_via_orthology)
Diseasemucinous adenocarcinoma (is_marker_for)

MUC2 MUC5AC

1.60e-0451192DOID:3030 (is_marker_for)
Diseasemicrocephaly (is_implicated_in)

MCPH1 EFTUD2

4.44e-0481192DOID:10907 (is_implicated_in)
DiseaseIntellectual Disability

KDM5A BRSK2 GON4L RBM28 GFER KCNK4 ZBTB40 CTNNA2

4.72e-044471198C3714756
Diseasebringing up phlegm, sputum or mucus on most days, self-reported

MUC2 MUC5AC

5.70e-0491192EFO_0009824
Diseasealopecia areata (is_marker_for)

KDM5A KDM4A

7.11e-04101192DOID:986 (is_marker_for)
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CYP4A11 PIK3CA

8.66e-04111192DOID:0110861 (biomarker_via_orthology)
Diseasecryptorchidism (biomarker_via_orthology)

KDM5A GFER

8.66e-04111192DOID:11383 (biomarker_via_orthology)
Diseasequality of life during menstruation measurement, acne

FMNL3 SDK1

8.66e-04111192EFO_0003894, EFO_0009366
Diseaseneuroimaging measurement

ZNF438 MCPH1 BRSK2 RNASE12 LUZP1 EFTUD2 TYK2 NXNL1 CBFA2T2 ADAMTS20 EML1 CDC5L

1.30e-03106911912EFO_0004346
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5B KDM5A

1.87e-03161192DOID:0050888 (implicated_via_orthology)
Diseasecyclic adenosine monophosphate measurement

RERGL ARAP2

2.11e-03171192EFO_0010473
Diseaselow affinity immunoglobulin gamma Fc region receptor II-a measurement

FCRLB HSPA6

2.11e-03171192EFO_0021969
Diseasefish consumption measurement

GRM5 EML1 SDK1

2.23e-03641193EFO_0010139
Diseaseresponse to clozapine

ZNF438 CTNNA2

2.37e-03181192GO_0097338
Diseaseinterstitial lung disease

SPAG1 POLR2K MUC5AC

2.54e-03671193EFO_0004244
Diseasecortical surface area measurement

ZNF438 ADAMTSL1 MCPH1 ENPP3 BRSK2 LUZP1 GRIP1 ADAMTS9 RASGEF1B ADAMTS20 EML1 CDC5L PDZD2

3.06e-03134511913EFO_0010736
Diseasebreast cancer (is_implicated_in)

KDM5B MCPH1 FANCD2 PIK3CA

3.24e-031501194DOID:1612 (is_implicated_in)
Diseasemelanoma

ZNF438 MTPAP PIK3CA ADAMTS20 KDM4A

3.38e-032481195C0025202
DiseaseJT interval

BACH1 RNASE12 RBM28 FMNL3 ZPBP2

3.38e-032481195EFO_0007885
Diseaseplatelet-to-lymphocyte ratio

RNASE12 TYK2 BAZ2A TNKS1BP1 ZPBP2 NUP160

3.60e-033631196EFO_0008446
DiseaseEpilepsy, Benign Psychomotor, Childhood

TRPV1 GRM5

3.86e-03231192C0393672
DiseaseEpilepsy, Lateral Temporal

TRPV1 GRM5

3.86e-03231192C0393682
DiseaseUncinate Epilepsy

TRPV1 GRM5

3.86e-03231192C0014558
DiseaseEpilepsy, Temporal Lobe

TRPV1 GRM5

3.86e-03231192C0014556

Protein segments in the cluster

PeptideGeneStartEntry
LHLSAAQCVAKERRP

FAM210A

56

Q96ND0
TPEQLDCIHDIRRRS

BACH1

551

O14867
KKHEDSAIPRRLECL

CDC5L

756

Q99459
HIRDCLPELKTRINV

DNM1L

296

O00429
KHRDFLQEVCLRPSA

BAZ2A

1471

Q9UIF9
PKHQERCREEIHSLL

CYP4A11

341

Q02928
VLSRIESHEDCRNLP

ARHGEF26

556

Q96DR7
RPRKHRSFNCLEDTE

ARAP2

1626

Q8WZ64
CTEAKDQEPRVTEHR

CD177

76

Q8N6Q3
KARDHTPEVLVRSCL

FAM187A

226

A6NFU0
STRIPEQRFCEHLKD

ARPP21

226

Q9UBL0
RHGLCVNKETETRPV

ADAMTS20

541

P59510
KASEHPDRNDCVAVL

ANKRD37

126

Q7Z713
HLKTSCEEQIRRKPD

RC3H2

766

Q9HBD1
RIVKEPTSHDNKDIC

RANBP2

1321

P49792
RTRLCLHNLPKAVDD

RBM28

486

Q9NW13
HKEPDCRTVRTQELG

IQCC

361

Q4KMZ1
VCEERDVSLPQSEHK

GDAP1L1

71

Q96MZ0
DSDVKSQERPCHLDL

KIAA1107

1061

Q9UPP5
CSIQRRHQKIVEEAP

ACACB

521

O00763
DCKSLREEPIHILNV

ACACB

1411

O00763
QRDPRIEASKVLLCH

NET1

376

Q7Z628
SCLKDRHDFRIPQEE

IFNA10

51

P01566
DCVRIHNKFRSEVKP

GLIPR1

36

P48060
RRLAQHKSEIECFTP

GRM5

881

P41594
KNRPTRHDVLDDSCD

MCPH1

611

Q8NEM0
EDCITRLIHLNKIDP

LANCL1

131

O43813
LQCIEREIISPRHEK

RNGTT

381

O60942
VRDVSHPEAELQKCS

GTPBP6

381

O43824
EVREKFLRAHPCVSD

KCNK4

41

Q9NYG8
SICHRDLKPENLLLD

BRSK2

136

Q8IWQ3
RVECVHARTNKAVPE

ADAMTSL1

1691

Q8N6G6
HPSVRERCLEEQKRR

GPR26

221

Q8NDV2
QRELLHCARAAKQTP

CBFA2T2

186

O43439
ECILRTSKVRPATEH

PCSK5

1726

Q92824
HIRRETVSKSVCAEP

FAM157A

306

C9JC47
IECRSVKDPHLSLEQ

MUC2

1336

Q02817
DKVSCPRTLIVRHET

MUC2

4531

Q02817
VARVSPHCKRSEAEA

PDZD2

1121

O15018
ADRIHNELSPLKLRC

PI4KA

421

P42356
TKRHRVCLEIPQEVS

KDM4A

396

O75164
CDVDKLHFTPRIQRL

KDM5B

76

Q9UGL1
EITRLQCRAKSHPEV

MUC5AC

1786

P98088
RPEEITRLQCRAKSH

MUC5AC

2156

P98088
RLQCRAKSHPEVSIE

MUC5AC

3566

P98088
EITRLQCRAESHPEV

MUC5AC

3996

P98088
ASDVIHATRRDIPCI

CDC42BPB

1161

Q9Y5S2
REQAQRTVLIHCPEK

MTPAP

71

Q9NVV4
FPRSLLERHQKEECQ

CYHR1

146

Q6ZMK1
REEHPEKCRSRTKNL

DGKH

791

Q86XP1
LCVEHQRLSDPDSDK

RASGEF1B

86

Q0VAM2
EEKAKVCLQARPRHS

KDM5A

956

P29375
VCKEAVDLRDLNSPH

PIK3CA

146

P42336
DTRPRFLELRKSECH

HLA-DRB3

31

P79483
HTDLKPEERKTCRNV

ADAMTS9

1716

Q9P2N4
QDAVSKLDDPLHLRC

HIP1R

636

O75146
ARRQQELKDPHCRDE

CTNNA2

191

P26232
KTKHECQNLESEPIR

CENPF

1161

P49454
IVLENSSREDKHECP

ELMO2

391

Q96JJ3
LEHRCQKAEVSLEPL

CROCC2

1501

H7BZ55
EEIVRNLSCRKPDQH

ENPP3

421

O14638
RECHSKLDPQGAVRD

FCGBP

1076

Q9Y6R7
ACVHLASKIEEAPRR

CCNL2

126

Q96S94
KEEAFQRRCHLEPNV

FMNL3

461

Q8IVF7
VTQEDRCDHLTLKEP

GON4L

141

Q3T8J9
QHCARVLDSPSRLDE

DTNB

386

O60941
SICHRDLKPENLLLD

BRSK1

151

Q8TDC3
EDSSPHEALRCRVIK

LUZP1

636

Q86V48
CSVQRRHQKIIEEAP

MCCC1

276

Q96RQ3
EQRLTSNCEIRIHPK

CEP192

1821

Q8TEP8
EINKTTERAPENCHL

ESCO1

471

Q5FWF5
DVEKLQQVDSLHPCR

CYP11B2

96

P19099
NDDVKCLAVHPDRIT

EML1

271

O00423
HQKRELEQICRPIFS

HSPA6

596

P17066
HTDPKTNLEREKRIC

CCDC168

6156

Q8NDH2
VLRCDTRLHPQKRDT

FCRLB

216

Q6BAA4
HDDRNKSRPVVITCV

GRIP1

171

Q9Y3R0
TTLRCHLSPEKNAED

BTN2A2

51

Q8WVV5
EEAKITCSAHREPRL

CD163

466

Q86VB7
IQRVIREPDHTCKKE

RNASE12

51

Q5GAN4
ISHEATACVVDRLRP

SDK1

1531

Q7Z5N4
RSKPVHELNREACDD

MGP

61

P08493
LREKLDLQHCVLPSR

FANCD2

301

Q9BXW9
NSALHVEDKAIPDCR

nan

201

A6NNC1
ALHVEDKAISDCRPS

nan

746

A6NNC1
TQTEHVLEPKKCRDL

MINAR1

476

Q9UPX6
LLDQLRSHCTVKDPE

SMG8

351

Q8ND04
HQLLEPIRDFEARKC

TRIM29

211

Q14134
AVKRKIRDESLCPQH

TRIM39

96

Q9HCM9
TPAESREHNRDCILL

SIDT2

776

Q8NBJ9
RIREPQTSHCKRAVE

RERGL

101

Q9H628
ICRKHRIQRVPEDSE

SLC35F5

491

Q8WV83
RDQVLKLCANHRITP

RGPD2

1391

P0DJD1
PQDALRCLHVSRDEA

RABGGTA

241

Q92696
DPHTKNCTLSIRDAR

SIGLEC9

96

Q9Y336
SVDKRHCSLQAVPEE

SCRIB

16

Q14160
KRQTAEDCPRTGEHQ

PRAMEF2

131

O60811
RRCKEINISFIPHES

STXBP3

131

O00186
EDICSKLQEIRNPIH

NUP160

656

Q12769
LERLDASAKVLPCQH

SH3RF1

16

Q7Z6J0
AEDLRKRLCRNHPDT

GFER

146

P55789
AARCQEPSAHLEARK

APOBR

126

Q0VD83
LSLDDVKRHNPCESL

ASIC1

486

P78348
ETKPQRRDQRTVLCH

CHRD

456

Q9H2X0
RICSEIRKIDDPLQH

ZNF615

76

Q8N8J6
RVLQRALECLPSKEH

PDCD11

1746

Q14690
IHDPEKVAVCTRFVR

ZC3H3

691

Q8IXZ2
QDPRKVRDCRLSTQH

ZSCAN21

191

Q9Y5A6
DQEPRSLTECLRRHK

NXNL1

171

Q96CM4
KDKCEALSPRRLHQE

SPEM3

1166

A0A1B0GUW6
DRLKPCRARQEHTSA

RIPOR3

546

Q96MK2
REIQEPECRHLSRKF

TRPV1

356

Q8NER1
TERALEAKAVPCHRQ

ZSCAN25

121

Q6NSZ9
DICKKSFTRRPHLEE

ZBTB41

466

Q5SVQ8
CEKHLQALAPESRAL

SPAG1

61

Q07617
ECREEHSKTPEERSL

TNKS1BP1

231

Q9C0C2
RNISHIPERLCESKE

ZNF627

61

Q7L945
ECHTENEIKSRDPIR

POLR2K

21

P53803
RKDCIKNSVLHRINP

ZNF229

246

Q9UJW7
LQSESLVNRRKPCHE

ZNF350

91

Q9GZX5
EHQCLSSEELKQRFP

PIPOX

116

Q9P0Z9
ICVHRKNENEPVSLE

TEX15

421

Q9BXT5
VDCLIEQTHPEIRKR

EFTUD2

146

Q15029
CHVPETRRKVEEAFN

THOP1

231

P52888
RKVQCRDHEAVPLSV

TPGS1

166

Q6ZTW0
SSEESHACPRLKRQL

ZNF438

716

Q7Z4V0
VDHSLQVVRLDSCRP

ZPBP2

266

Q6X784
QRAVEEDGHLKCPRS

USP36

966

Q9P275
EHKEDLIQCVTQLRP

ZBTB40

356

Q9NUA8
HRQDNKCLELSLPSR

TYK2

396

P29597
IARELEDTLHCKISP

NLRP13

596

Q86W25
KSPQIFDDERCRHQV

MYO1D

596

O94832