Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	EFHC2 BMP1 HSPG2 FAM20C THBS1 CDH20 CGREF1 ENPP3 FAT3 TLL2 NID1 EDEM1 CDH19 ATP2A1 LRP1B	1.38e-06	749	91	15	GO:0005509
GeneOntologyMolecularFunction	calcium-dependent ATPase activity	ATP2A1 ATP2A3	1.23e-04	4	91	2	GO:0030899
GeneOntologyMolecularFunction	collagen V binding	HSPG2 THBS1	2.04e-04	5	91	2	GO:0070052
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS19 BMP1 ADAMTS7 TLL2 ADAM22	2.22e-04	120	91	5	GO:0004222
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNT2 KCNB1 KCND2	2.47e-04	27	91	3	GO:0015271
GeneOntologyMolecularFunction	collagen binding	HSPG2 THBS1 P3H1 NID1	5.14e-04	81	91	4	GO:0005518
GeneOntologyBiologicalProcess	collagen fibril organization	ADAMTS19 BMP1 ADAMTS7 P3H1 TLL2	2.05e-05	76	90	5	GO:0030199
Domain	EGF	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B ADAM22 SORL1	1.63e-06	235	88	9	SM00181
Domain	EGF_3	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B ADAM22 SORL1	1.63e-06	235	88	9	PS50026
Domain	EGF_CA	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B	1.75e-06	122	88	7	SM00179
Domain	EGF-like_Ca-bd_dom	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B	1.95e-06	124	88	7	IPR001881
Domain	EGF-like_dom	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B ADAM22 SORL1	2.63e-06	249	88	9	IPR000742
Domain	EGF_CA	BMP1 THBS1 FAT3 TLL2 NID1 LRP1B	3.20e-06	86	88	6	PF07645
Domain	EGF-like_CS	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B ADAM22 SORL1	3.87e-06	261	88	9	IPR013032
Domain	EGF_2	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B ADAM22 SORL1	4.37e-06	265	88	9	PS01186
Domain	TSP_1	ADAMTS19 THBS1 SEMA5B ADAMTS7 CCN2	1.17e-05	63	88	5	PF00090
Domain	TPR_REGION	TTC8 RMDN1 P3H1 PTPN23 TTC3 ANAPC5 DNAJC3	1.29e-05	165	88	7	PS50293
Domain	TPR	TTC8 RMDN1 P3H1 PTPN23 TTC3 ANAPC5 DNAJC3	1.29e-05	165	88	7	PS50005
Domain	TSP1	ADAMTS19 THBS1 SEMA5B ADAMTS7 CCN2	1.37e-05	65	88	5	SM00209
Domain	TSP1_rpt	ADAMTS19 THBS1 SEMA5B ADAMTS7 CCN2	1.37e-05	65	88	5	IPR000884
Domain	TSP1	ADAMTS19 THBS1 SEMA5B ADAMTS7 CCN2	1.37e-05	65	88	5	PS50092
Domain	EGF_1	BMP1 HSPG2 THBS1 FAT3 TLL2 NID1 LRP1B ADAM22	2.71e-05	255	88	8	PS00022
Domain	Ldl_recept_b	NID1 LRP1B SORL1	3.54e-05	14	88	3	PF00058
Domain	LDLRB	NID1 LRP1B SORL1	3.54e-05	14	88	3	PS51120
Domain	-	ADAMTS19 BMP1 ADAMTS7 TLL2 ADAM22	4.00e-05	81	88	5	3.40.390.10
Domain	MetalloPept_cat_dom	ADAMTS19 BMP1 ADAMTS7 TLL2 ADAM22	4.00e-05	81	88	5	IPR024079
Domain	LY	NID1 LRP1B SORL1	4.41e-05	15	88	3	SM00135
Domain	LDLR_classB_rpt	NID1 LRP1B SORL1	4.41e-05	15	88	3	IPR000033
Domain	BMP_1/tolloid-like	BMP1 TLL2	6.56e-05	3	88	2	IPR015446
Domain	P-type_ATPase_IIA	ATP2A1 ATP2A3	6.56e-05	3	88	2	IPR005782
Domain	TPR-contain_dom	TTC8 P3H1 PTPN23 TTC3 ANAPC5 DNAJC3	7.65e-05	150	88	6	IPR013026
Domain	EGF_Ca-bd_CS	BMP1 FAT3 TLL2 NID1 LRP1B	9.49e-05	97	88	5	IPR018097
Domain	ZINC_PROTEASE	ADAMTS19 BMP1 ADAMTS7 TLL2 ADAM22	9.96e-05	98	88	5	PS00142
Domain	EGF_CA	BMP1 FAT3 TLL2 NID1 LRP1B	1.05e-04	99	88	5	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	BMP1 FAT3 TLL2 NID1 LRP1B	1.44e-04	106	88	5	IPR000152
Domain	EGF	BMP1 HSPG2 TLL2 NID1 LRP1B	3.23e-04	126	88	5	PF00008
Domain	Peptidase_M12A	BMP1 TLL2	3.25e-04	6	88	2	IPR001506
Domain	Astacin	BMP1 TLL2	3.25e-04	6	88	2	PF01400
Domain	-	TTC8 RMDN1 P3H1 TTC3 ANAPC5 DNAJC3	4.39e-04	207	88	6	1.25.40.10
Domain	HEMATOPO_REC_S_F1	IL2RB CRLF2	6.03e-04	8	88	2	PS01355
Domain	Hempt_rcpt_S_F1_CS	IL2RB CRLF2	7.73e-04	9	88	2	IPR003531
Domain	TPR-like_helical_dom	TTC8 RMDN1 P3H1 TTC3 ANAPC5 DNAJC3	8.17e-04	233	88	6	IPR011990
Domain	Pep_M12B_propep	ADAMTS19 ADAMTS7 ADAM22	8.17e-04	39	88	3	PF01562
Domain	Peptidase_M12B_N	ADAMTS19 ADAMTS7 ADAM22	8.17e-04	39	88	3	IPR002870
Domain	-	NID1 LRP1B SORL1	8.17e-04	39	88	3	2.120.10.30
Domain	Growth_fac_rcpt_	BMP1 HSPG2 NID1 CCN2 LRP1B	8.55e-04	156	88	5	IPR009030
Domain	LDLR_class-A_CS	HSPG2 LRP1B SORL1	8.80e-04	40	88	3	IPR023415
Domain	DISINTEGRIN_1	ADAMTS19 ADAMTS7 ADAM22	8.80e-04	40	88	3	PS00427
Domain	Reprolysin	ADAMTS19 ADAMTS7 ADAM22	8.80e-04	40	88	3	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAMTS7 ADAM22	8.80e-04	40	88	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAMTS7 ADAM22	8.80e-04	40	88	3	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAMTS7 ADAM22	8.80e-04	40	88	3	IPR001590
Domain	PTPase_domain	PTPRK PTPN23 CDC14B	9.47e-04	41	88	3	IPR000242
Domain	Disintegrin_dom	ADAMTS19 ADAMTS7 ADAM22	9.47e-04	41	88	3	IPR001762
Domain	Y_phosphatase	PTPRK PTPN23 CDC14B	9.47e-04	41	88	3	PF00102
Domain	Hydrolase_3	ATP2A1 ATP2A3	9.64e-04	10	88	2	PF08282
Domain	Ldl_recept_a	HSPG2 LRP1B SORL1	1.24e-03	45	88	3	PF00057
Domain	ASX_HYDROXYL	BMP1 FAT3 NID1 LRP1B	1.28e-03	100	88	4	PS00010
Domain	6-blade_b-propeller_TolB-like	NID1 LRP1B SORL1	1.33e-03	46	88	3	IPR011042
Domain	-	HSPG2 LRP1B SORL1	1.33e-03	46	88	3	4.10.400.10
Domain	LDLRA_1	HSPG2 LRP1B SORL1	1.50e-03	48	88	3	PS01209
Domain	LDrepeatLR_classA_rpt	HSPG2 LRP1B SORL1	1.59e-03	49	88	3	IPR002172
Domain	LDLa	HSPG2 LRP1B SORL1	1.59e-03	49	88	3	SM00192
Domain	LDLRA_2	HSPG2 LRP1B SORL1	1.59e-03	49	88	3	PS50068
Domain	ATPase_P-typ_TM_dom	ATP2A1 ATP2A3	2.52e-03	16	88	2	IPR023298
Domain	-	ATP2A1 ATP2A3	2.52e-03	16	88	2	1.20.1110.10
Domain	Laminin_G	HSPG2 THBS1 FAT3	2.59e-03	58	88	3	IPR001791
Domain	PTPc_motif	PTPRK PTPN23 CDC14B	2.72e-03	59	88	3	SM00404
Domain	Tyr_Pase_cat	PTPRK PTPN23 CDC14B	2.72e-03	59	88	3	IPR003595
Domain	ATPase_P-typ_cation-transptr_C	ATP2A1 ATP2A3	2.85e-03	17	88	2	IPR006068
Domain	Cation_ATPase_C	ATP2A1 ATP2A3	2.85e-03	17	88	2	PF00689
Domain	LH2	PKD1L1 ALOXE3	3.20e-03	18	88	2	SM00308
Domain	Cation_ATPase_N	ATP2A1 ATP2A3	3.20e-03	18	88	2	PF00690
Domain	Cation_ATPase_N	ATP2A1 ATP2A3	3.20e-03	18	88	2	SM00831
Domain	TPR	TTC8 TTC3 ANAPC5 DNAJC3	3.24e-03	129	88	4	SM00028
Domain	PLAC	ADAMTS19 ADAMTS7	3.56e-03	19	88	2	PS50900
Domain	ATPase_P-typ_cation-transptr_N	ATP2A1 ATP2A3	3.56e-03	19	88	2	IPR004014
Domain	PLAC	ADAMTS19 ADAMTS7	3.56e-03	19	88	2	IPR010909
Domain	TPR_repeat	TTC8 TTC3 ANAPC5 DNAJC3	3.61e-03	133	88	4	IPR019734
Domain	-	PKD1L1 ALOXE3	4.35e-03	21	88	2	2.60.60.20
Domain	PLAT	PKD1L1 ALOXE3	4.35e-03	21	88	2	PF01477
Domain	PLAT/LH2_dom	PKD1L1 ALOXE3	4.35e-03	21	88	2	IPR001024
Domain	PLAT	PKD1L1 ALOXE3	4.35e-03	21	88	2	PS50095
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS19 HSPG2 THBS1 MGAT2 B4GAT1 SEMA5B ADAMTS7	9.74e-06	143	74	7	M27275
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS19 THBS1 B4GAT1 SEMA5B ADAMTS7	2.80e-05	68	74	5	M27303
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 THBS1 SEMA5B ADAMTS7	5.01e-05	39	74	4	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 THBS1 SEMA5B ADAMTS7	5.01e-05	39	74	4	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS19 THBS1 B4GAT1 SEMA5B ADAMTS7	2.66e-04	109	74	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS19 THBS1 B4GAT1 SEMA5B ADAMTS7	2.89e-04	111	74	5	M27416
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS19 HSPG2 THBS1 MGAT2 B4GAT1 SEMA5B ADAMTS7	3.32e-04	250	74	7	M27554
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	BMP1 HSPG2 THBS1 MANBA B4GAT1 PTPRK CGREF1 P3H1 NID1 MICA CCN2 EDEM1 LRP1B ATP2A3 DNAJC3 ADAM22 SORL1	1.30e-08	1201	91	17	35696571
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS19 THBS1 SEMA5B ADAMTS7 CCN2	1.64e-06	75	91	5	20637190
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	BMP1 HSPG2 FAM20C THBS1 ADAMTS7 NID1 CCN2	4.19e-06	248	91	7	24006456
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	HSPG2 MYOG NID1	6.18e-06	14	91	3	19783738
Pubmed	Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma.	THBS1 CCN2	6.77e-06	2	91	2	19698122
Pubmed	Biomarker LEPRE1 induces pelitinib-specific drug responsiveness by regulating ABCG2 expression and tumor transition states in human leukemia and lung cancer.	P3H1 ABCG2	6.77e-06	2	91	2	35190588
Pubmed	CCN2 promotes drug resistance in osteosarcoma by enhancing ABCG2 expression.	CCN2 ABCG2	6.77e-06	2	91	2	30317661
Pubmed	CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes.	HSPG2 CCN2	6.77e-06	2	91	2	12811819
Pubmed	Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation.	CCN2 ATP2A3	6.77e-06	2	91	2	25027872
Pubmed	Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy.	FAT3 LRP1B	6.77e-06	2	91	2	35069585
Pubmed	Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.	HSPG2 NID1	6.77e-06	2	91	2	11427896
Pubmed	BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan.	BMP1 HSPG2	6.77e-06	2	91	2	15591058
Pubmed	Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan.	HSPG2 NID1	6.77e-06	2	91	2	11574465
Pubmed	Antitumor immunity and prognosis value elicited by FAT3 and LRP1B co-mutation in endometrial cancer.	FAT3 LRP1B	6.77e-06	2	91	2	38696842
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	ZNF462 ANO2 ASH1L	9.47e-06	16	91	3	16096065
Pubmed	Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.	MICA IL2RB	2.03e-05	3	91	2	21653640
Pubmed	Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli.	THBS1 CCN2	2.03e-05	3	91	2	16270194
Pubmed	HBV suppresses expression of MICA/B on hepatoma cells through up-regulation of transcription factors GATA2 and GATA3 to escape from NK cell surveillance.	GATA2 MICA	2.03e-05	3	91	2	27528231
Pubmed	Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.	CDH20 CDH19	2.03e-05	3	91	2	10995570
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL2	2.03e-05	3	91	2	18824173
Pubmed	The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.	ATP2A1 ATP2A3	2.03e-05	3	91	2	16410239
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	2.03e-05	3	91	2	18286185
Pubmed	Identification of genes promoting skin youthfulness by genome-wide association study.	KCND2 EDEM1	2.03e-05	3	91	2	24037343
Pubmed	The axis of thrombospondin-1, transforming growth factor beta and connective tissue growth factor: an emerging therapeutic target in rheumatoid arthritis.	THBS1 CCN2	2.03e-05	3	91	2	19485899
Pubmed	ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.	THBS1 ADAMTS7	2.03e-05	3	91	2	25712208
Pubmed	BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1.	BMP1 THBS1	2.03e-05	3	91	2	32636307
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	HSPG2 THBS1 HACE1 CCN2 IL2RB CDC14B	2.18e-05	214	91	6	22199357
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	HSPG2 NID1 SORL1	2.57e-05	22	91	3	18448648
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RSBN1 LINS1 MANBA TBC1D25 ACTL6A TTC3 ACAP2 ANAPC5 WWC1 HNRNPL SMTN	3.03e-05	925	91	11	28986522
Pubmed	MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure.	THBS1 CCN2	4.05e-05	4	91	2	21501375
Pubmed	The collagen type XVIII endostatin domain is co-localized with perlecan in basement membranes in vivo.	HSPG2 NID1	4.05e-05	4	91	2	12588956
Pubmed	The protein-protein interaction between connective tissue growth factor and annexin A2 is relevant to pannus formation in rheumatoid arthritis.	THBS1 CCN2	4.05e-05	4	91	2	34702315
Pubmed	The nongastric H+-K+-ATPases: molecular and functional properties.	ATP2A1 ATP2A3	4.05e-05	4	91	2	10362770
Pubmed	Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.	ATP2A1 ATP2A3	4.05e-05	4	91	2	25110346
Pubmed	Biochemical characterization of the native Kv2.1 potassium channel.	KCNB1 KCND2	4.05e-05	4	91	2	16008572
Pubmed	Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.	CDC14B WWC1	4.05e-05	4	91	2	22784093
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	C5orf22 KIF1A PTPRK PTPN23 NID1 EDEM1 ATP2A1 DNAJC3 WWC1 HNRNPL SORL1	4.83e-05	974	91	11	28675297
Pubmed	YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct.	MYOG CCN2 SMTN	6.03e-05	29	91	3	32520726
Pubmed	Expression and localization of proteoglycans during limb myogenic activation.	HSPG2 MYOG	6.74e-05	5	91	2	11357198
Pubmed	The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1.	HSPG2 NID1	6.74e-05	5	91	2	7670489
Pubmed	Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.	HSPG2 NID1	6.74e-05	5	91	2	9524110
Pubmed	Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens.	HSPG2 NID1	6.74e-05	5	91	2	12243745
Pubmed	Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.	HSPG2 NID1	6.74e-05	5	91	2	11493006
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	BMP1 TLL2	6.74e-05	5	91	2	10479448
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	HSPG2 FAM20C THBS1 SLC12A3 P3H1 ENPP3 PTPN23 NID1 DYNC1H1 HNRNPL SORL1	7.04e-05	1016	91	11	19056867
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	HSPG2 MANBA P3H1 EDEM1 SORL1	7.35e-05	164	91	5	32409323
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	HSPG2 THBS1 P3H1 CCN2	7.90e-05	86	91	4	28327460
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	KCNB1 KCND2 CCN2	9.78e-05	34	91	3	26378152
Pubmed	Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.	HSPG2 NID1	1.01e-04	6	91	2	22753893
Pubmed	A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein.	RASA1 DNAJC3	1.01e-04	6	91	2	11116152
Pubmed	The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin.	HSPG2 NID1	1.01e-04	6	91	2	11956183
Pubmed	Nidogen-2: a new basement membrane protein with diverse binding properties.	HSPG2 NID1	1.01e-04	6	91	2	9733643
Pubmed	Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins.	HSPG2 NID1	1.01e-04	6	91	2	10544250
Pubmed	Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions.	HSPG2 CCN2	1.01e-04	6	91	2	12036876
Pubmed	Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone.	MYOG NID1	1.01e-04	6	91	2	15302855
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	BMP1 MANBA P3H1 RAD17	1.31e-04	98	91	4	34943047
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	ATP2A1 ATP2A3	1.41e-04	7	91	2	24786561
Pubmed	Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain.	PCSK1 KCNB1	1.41e-04	7	91	2	10894496
Pubmed	Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP).	PCSK1 RASA1	1.41e-04	7	91	2	8198617
Pubmed	Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.	HSPG2 THBS1	1.41e-04	7	91	2	12242711
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE HSPG2 FAM20C ADAMTS7 MYO9B GATA2 TBC1D25 TTC3 ATP2A3 CDC14B DYNC1H1	1.47e-04	1105	91	11	35748872
Pubmed	Proteome-wide analysis of phospho-regulated PDZ domain interactions.	ANO2 SLC15A5 ADAM22	1.85e-04	42	91	3	30126976
Pubmed	Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.	HSPG2 NID1	1.88e-04	8	91	2	12015298
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2A1 ATP2A3	1.88e-04	8	91	2	10951186
Pubmed	The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor.	HSPG2 NID1	1.88e-04	8	91	2	11847210
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A1 ATP2A3	1.88e-04	8	91	2	19033399
Pubmed	Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality.	EDEM1 DNAJC3	1.88e-04	8	91	2	20197277
Pubmed	Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.	ATP2A1 ATP2A3	1.88e-04	8	91	2	27923914
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1A DYNC1H1	1.88e-04	8	91	2	25818806
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	HSPG2 MANBA B4GAT1 P3H1 ENPP3 ACTL6A HNRNPL SORL1	2.10e-04	613	91	8	22268729
Pubmed	Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners.	HSPG2 NID1	2.41e-04	9	91	2	22952693
Pubmed	A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.	ATP2A1 ATP2A3	2.41e-04	9	91	2	25640239
Pubmed	Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro.	HSPG2 NID1	2.41e-04	9	91	2	23320101
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	THBS1 MYO9B AMOTL1 CCN2 TTC3 DYNC1H1	2.44e-04	332	91	6	37433992
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	HSPG2 THBS1 DYNC1H1	2.93e-04	49	91	3	21362503
Pubmed	Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling.	KIF1A MYOG	3.01e-04	10	91	2	24656932
Pubmed	Generation of a conditionally null allele of the laminin alpha1 gene.	HSPG2 NID1	3.01e-04	10	91	2	16100707
Pubmed	Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation.	HSPG2 CCN2	3.01e-04	10	91	2	22421594
Pubmed	DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release.	ADAM22 DYNC1H1	3.01e-04	10	91	2	36585413
Pubmed	Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.	HSPG2 MYOG	3.01e-04	10	91	2	16554364
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	HSPG2 THBS1 NID1	3.11e-04	50	91	3	23658023
Pubmed	Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.	HSPG2 NID1	3.67e-04	11	91	2	17023412
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	HSPG2 NID1	3.67e-04	11	91	2	7500359
Pubmed	SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.	HSPG2 THBS1	3.67e-04	11	91	2	2745554
Pubmed	Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.	ADAMTS19 ADAMTS7	3.67e-04	11	91	2	29337306
Pubmed	SVEP1 is an endogenous ligand for the orphan receptor PEAR1.	HSPG2 NID1	3.67e-04	11	91	2	36792666
Pubmed	The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.	CCN2 WWC1	3.67e-04	11	91	2	33483469
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ZNF462 THBS1 HACE1 NID1 ACTL6A ATP2A3 HNRNPL	4.06e-04	513	91	7	25798074
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	HSPG2 NID1	4.39e-04	12	91	2	16750824
Pubmed	Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy.	CDH20 CDH19	4.39e-04	12	91	2	22102170
Pubmed	Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.	HSPG2 NID1	4.39e-04	12	91	2	16024816
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	MYO9B SCML1 DHX38 ASH1L ACTL6A ANAPC5 DYNC1H1	5.09e-04	533	91	7	30554943
Pubmed	Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.	HSPG2 NID1	5.18e-04	13	91	2	12682087
Pubmed	Basement membranes in skin are differently affected by lack of nidogen 1 and 2.	HSPG2 NID1	5.18e-04	13	91	2	18356808
Pubmed	YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling.	GATA2 CCN2	5.18e-04	13	91	2	33060128
Pubmed	The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.	HSPG2 THBS1 CCN2 ACAP2	5.26e-04	141	91	4	32322062
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	PCSK1 RASA1 ZNF569	5.59e-04	61	91	3	8662221
Pubmed	Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.	PCSK1 RASA1	6.04e-04	14	91	2	1354647
Pubmed	Membrane-type MMPs are indispensable for placental labyrinth formation and development.	HSPG2 NID1	6.04e-04	14	91	2	20858856
Pubmed	A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.	PCSK1 RASA1	6.04e-04	14	91	2	8114702
Interaction	PI15 interactions	BMP1 HSPG2 THBS1 MANBA ADAMTS7 SORL1	1.68e-06	83	88	6	int:PI15
Interaction	LYZL1 interactions	BMP1 THBS1 MANBA ADAMTS7 EDEM1 SORL1	1.30e-05	118	88	6	int:LYZL1
Interaction	IGFL3 interactions	MANBA ADAMTS7 MICA LRP1B SORL1	1.92e-05	75	88	5	int:IGFL3
Interaction	COBLL1 interactions	THBS1 SCML1 AMOTL1 DHX38 CDADC1	2.05e-05	76	88	5	int:COBLL1
Interaction	TAFA3 interactions	MANBA KIF1A MICA LRP1B SORL1	2.33e-05	78	88	5	int:TAFA3
Interaction	GPIHBP1 interactions	BMP1 MANBA PTPRK ADAMTS7 MICA ADAM22	2.57e-05	133	88	6	int:GPIHBP1
Interaction	CDADC1 interactions	SCML1 AMOTL1 CDADC1	2.83e-05	14	88	3	int:CDADC1
Interaction	PRG2 interactions	BMP1 HSPG2 THBS1 MANBA ADAMTS7 P3H1 TLL2 SORL1	3.50e-05	285	88	8	int:PRG2
Interaction	SLURP1 interactions	BMP1 MANBA ADAMTS7 TLL2 MICA SORL1	4.01e-05	144	88	6	int:SLURP1
Interaction	DEFB136 interactions	MANBA ADAMTS7 MICA LRP1B	4.03e-05	44	88	4	int:DEFB136
Interaction	CMA1 interactions	MANBA PTPRK ADAMTS7 SORL1	4.81e-05	46	88	4	int:CMA1
Interaction	MTDH interactions	HSPG2 FAM20C THBS1 HACE1 CCN2 ACTL6A EDEM1 ATP2A1 IL2RB CDC14B	7.01e-05	505	88	10	int:MTDH
Interaction	FBXO2 interactions	BMP1 HSPG2 MANBA PTPRK ADAMTS7 AMOTL1 NID1 LRP1B SORL1	7.71e-05	411	88	9	int:FBXO2
Interaction	TRGV3 interactions	BMP1 MANBA ADAMTS7 DNAJC3	9.77e-05	55	88	4	int:TRGV3
Interaction	EDN3 interactions	BMP1 HSPG2 MANBA ADAMTS7 SORL1	1.11e-04	108	88	5	int:EDN3
Interaction	LRPAP1 interactions	FAM20C TTC3 LRP1B DNAJC3 HNRNPL SORL1	1.38e-04	180	88	6	int:LRPAP1
Interaction	DYNLL2 interactions	RSBN1 SCML1 AMOTL1 CDADC1 TTC3 DYNC1H1 WWC1	1.54e-04	263	88	7	int:DYNLL2
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL2	2.13e-04	6	69	2	894
GeneFamily	ATPases Ca2+ transporting	ATP2A1 ATP2A3	5.08e-04	9	69	2	1209
GeneFamily	CD molecules\|Type II classical cadherins	CDH20 CDH19	1.09e-03	13	69	2	1186
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS19 ADAMTS7	2.35e-03	19	69	2	50
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 GATA2 NID1 CCN2 ABCG2 CHST1 MPZL2 SMTN	2.96e-10	198	91	9	72e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 CHST1 MPZL2 SMTN	7.59e-09	198	91	8	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 GATA2 NID1 CCN2 ABCG2 CHST1 SMTN	7.90e-09	199	91	8	9c40b3ee39860e9d8edafd007daec11abdd95435
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 P3H1 NID1 CCN2 ABCG2 CHST1 SMTN	7.90e-09	199	91	8	d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 P3H1 NID1 CCN2 ABCG2 CHST1 SMTN	7.90e-09	199	91	8	cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 GATA2 NID1 CCN2 ABCG2 CHST1 SMTN	7.90e-09	199	91	8	72b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 GATA2 NID1 CCN2 ABCG2 MPZL2 SMTN	7.90e-09	199	91	8	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 ADAMTS7 NID1 CCN2 ABCG2 MPZL2 SMTN	7.90e-09	199	91	8	463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 ANO2 GATA2 CCN2 ABCG2 CHST1 SMTN	7.90e-09	199	91	8	63c01e8961f48ed1bed4ab619cacf318cd6de7b9
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	RASIP1 SEMA5B LYPD5 NID1 CHST1 CDH19 SMTN	6.52e-08	172	91	7	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	10x5'-GI_small-bowel-Mast\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF462 HSPG2 ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	7.06e-08	174	91	7	e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCell	10x5'-GI_small-bowel-Mast-Mast_cells\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF462 HSPG2 ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	7.06e-08	174	91	7	05525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 CHST1 MPZL2	1.48e-07	194	91	7	ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 CHST1 MPZL2	1.48e-07	194	91	7	cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASIP1 HSPG2 ANO2 AMOTL1 GATA2 CCN2 MPZL2	1.64e-07	197	91	7	87eda06344498dc66cac292cf89746dc90b5cf67
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 CHST1 MPZL2	1.64e-07	197	91	7	9244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 CHST1 MPZL2	1.70e-07	198	91	7	7cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 MPZL2 SMTN	1.76e-07	199	91	7	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 MPZL2 SMTN	1.82e-07	200	91	7	86ec951234015ced7126b016199e5869a0f22478
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 GATA2 NID1 CCN2 ABCG2 SMTN	1.82e-07	200	91	7	c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 MPZL2 SMTN	1.82e-07	200	91	7	061ba851f941c616ddb462512e826c412881c3ce
ToppCell	Severe-Myeloid-Mast-\|Severe / Condition, Lineage, Cell class and cell subclass	ZNF462 ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	5.37e-07	145	91	6	ce307d45425a5191882078f049f85477eec40b69
ToppCell	Severe-Myeloid-Mast\|Severe / Condition, Lineage, Cell class and cell subclass	ZNF462 ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	5.37e-07	145	91	6	e0bfd2ffdbd6c197ef0a04e983396ebd87ef7127
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	CDH20 KCNB1 KIF1A LRP1B ADAM22 DYNC1H1	1.72e-06	177	91	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 FAM20C KCNT2 CGREF1 TLL2 NID1	1.90e-06	180	91	6	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	ZNF462 ADAMTS7 ENPP3 GATA2 ATP2A3 CRLF2	2.02e-06	182	91	6	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BMP1 HSPG2 KCNT2 ENPP3 NID1 CCN2	2.15e-06	184	91	6	d754c3de621429b220ae4ac426cdfc619e848462
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	ZNF462 ADAMTS7 ENPP3 GATA2 ATP2A3 CRLF2	2.29e-06	186	91	6	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 CHST1	2.29e-06	186	91	6	a906020a8df6fcca474b278f746c553b177a56b4
ToppCell	10x5'-Lung-Mast\|Lung / Manually curated celltypes from each tissue	ZNF462 HSPG2 ADAMTS7 ENPP3 GATA2 CRLF2	2.37e-06	187	91	6	f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell	10x5'-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	ZNF462 HSPG2 ADAMTS7 ENPP3 GATA2 CRLF2	2.37e-06	187	91	6	da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 MPZL2	2.59e-06	190	91	6	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	ZNF462 ADAMTS7 ENPP3 GATA2 ATP2A3 CRLF2	2.59e-06	190	91	6	379dbac19110b76079a7a53209569e060a852acb
ToppCell	Control-Endothelial-VE_Venous\|Control / Disease state, Lineage and Cell class	RASIP1 HSPG2 ANO2 ZCWPW2 GATA2 CCN2	2.67e-06	191	91	6	617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RASIP1 HSPG2 THBS1 GATA2 CCN2 MPZL2	2.75e-06	192	91	6	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASIP1 HSPG2 THBS1 GATA2 NID1 SMTN	2.84e-06	193	91	6	5d42979d811ee13a07dee08a3743a90776017cb4
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	HSPG2 ADAMTS7 GATA2 NID1 ABCG2 CHST1	2.84e-06	193	91	6	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASIP1 HSPG2 THBS1 GATA2 NID1 SMTN	2.84e-06	193	91	6	95e64b9580d30c28702639a043a8b72ce1cadeb6
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASIP1 HSPG2 THBS1 GATA2 NID1 SMTN	2.84e-06	193	91	6	97c0730aad9135ac681250b3871cc094a28f80a7
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 CCN2 ABCG2 MPZL2 SMTN	2.84e-06	193	91	6	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	HSPG2 ADAMTS7 GATA2 NID1 ABCG2 CHST1	2.84e-06	193	91	6	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	IPF-Endothelial-VE_Arterial\|World / Disease state, Lineage and Cell class	RASIP1 HSPG2 ANO2 ZCWPW2 GATA2 CCN2	2.84e-06	193	91	6	70a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 BMP1 FAM20C KIF1A ATP2A3 ANAPC5	2.92e-06	194	91	6	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HSPG2 GATA2 NID1 CCN2 ABCG2 MPZL2	3.01e-06	195	91	6	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	Control-Endothelial-VE_Arterial\|Control / Disease state, Lineage and Cell class	RASIP1 HSPG2 ANO2 ZCWPW2 GATA2 CCN2	3.01e-06	195	91	6	56c66a3655820961e1390b8f4bcc5618e8d0c5a8
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 KIF1A ASH1L TTC3 ATP2A3 DYNC1H1	3.01e-06	195	91	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNB1 KIF1A ASH1L TTC3 ATP2A3 DYNC1H1	3.01e-06	195	91	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 MPZL2	3.10e-06	196	91	6	ed818de15f84f7f28bd06fd69d7876710da232a0
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 SMTN	3.19e-06	197	91	6	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 ADAMTS7 NID1 CCN2 ABCG2	3.19e-06	197	91	6	a312d9cf4ced949307eb9620be4eed926300b892
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 CCN2 ABCG2 CHST1 SMTN	3.19e-06	197	91	6	9e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 SMTN	3.19e-06	197	91	6	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 NID1 CCN2 ABCG2 MPZL2	3.29e-06	198	91	6	218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BMP1 HSPG2 P3H1 NID1 CCN2 SMTN	3.29e-06	198	91	6	8b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BMP1 HSPG2 P3H1 NID1 CCN2 SMTN	3.29e-06	198	91	6	eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP1 HSPG2 CGREF1 P3H1 NID1 CCN2	3.29e-06	198	91	6	1b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASIP1 HSPG2 GATA2 CCN2 ABCG2 SMTN	3.39e-06	199	91	6	c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDH20 KCNT2 CDADC1 CCN2 CDH19 LRP1B	3.48e-06	200	91	6	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDH20 KCNT2 CDADC1 CCN2 CDH19 LRP1B	3.48e-06	200	91	6	7c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCell	Children_(3_yrs)-Immune-mast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFHC2 ENPP3 GATA2 LRP1B CRLF2	1.47e-05	151	91	5	bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 KCNT2 NID1 CDH19 SMTN	1.72e-05	156	91	5	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	1.72e-05	156	91	5	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	1.72e-05	156	91	5	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 KCNT2 NID1 CDH19 SMTN	1.77e-05	157	91	5	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	Fetal_29-31_weeks-Immune-mast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EFHC2 CGREF1 ENPP3 GATA2 ATP2A3	2.12e-05	163	91	5	03b2ec226adffba3ce893f3d12e549c841e662fd
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	2.25e-05	165	91	5	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	2.25e-05	165	91	5	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	2.25e-05	165	91	5	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RASIP1 HSPG2 ANO2 GATA2 ALOXE3	2.32e-05	166	91	5	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	ILEUM-non-inflamed-(4)_Mast\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EFHC2 THBS1 ENPP3 GATA2 CRLF2	2.38e-05	167	91	5	de0cb257def6049830af068f8f74829a708b810f
ToppCell	ILEUM-non-inflamed-(4)_Mast_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EFHC2 THBS1 ENPP3 GATA2 CRLF2	2.38e-05	167	91	5	85b39e05eb6e18e06b47e374d808e479ca65173c
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF462 RASA1 ENPP3 GATA2 ADAM22	2.45e-05	168	91	5	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	2.52e-05	169	91	5	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	Control-Myeloid-Mast\|Control / Disease state, Lineage and Cell class	ZNF462 ADAMTS7 ENPP3 GATA2 CRLF2	2.60e-05	170	91	5	9a14deb7f7cd4a49c217eba4023f7bf1dec6c902
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 FAT3 AMOTL1 CDH19 LRP1B	2.60e-05	170	91	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	ADAMTS7 ENPP3 GATA2 LRP1B CRLF2	2.60e-05	170	91	5	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	Control-Myeloid-Mast\|World / Disease state, Lineage and Cell class	ZNF462 ADAMTS7 ENPP3 GATA2 CRLF2	2.67e-05	171	91	5	ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HSPG2 GATA2 CCN2 ABCG2 MPZL2	2.75e-05	172	91	5	c3a99828838af3b85c8c885d69cc8018f55ced50
ToppCell	Immune-mast_cell\|World / Lineage, Cell type, age group and donor	EFHC2 ENPP3 GATA2 ATP2A3 CRLF2	2.75e-05	172	91	5	6e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCell	Endothelial-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	RASIP1 SEMA5B ADAMTS7 LYPD5 NID1	2.75e-05	172	91	5	8a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RASIP1 HSPG2 ANO2 GATA2 CHST1	2.75e-05	172	91	5	de9b11ab109d04937186c09772cec9105a935f95
ToppCell	facs-Marrow-B-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 CHST1 EDEM1 DNAJC3 CDC14B	2.75e-05	172	91	5	65b8935a972bf00b7a10dc2d442128fc0ed78bcb
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EFHC2 HSPG2 ANO2 ZCWPW2 GATA2	2.90e-05	174	91	5	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	RASIP1 HSPG2 ANO2 CHST1 MPZL2	2.98e-05	175	91	5	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RASIP1 LYPD5 PKD1L1 ABCG2 CHST1	2.98e-05	175	91	5	90302e8a44858ef3b2a165b88284d4788d591a99
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	RASIP1 HSPG2 ANO2 CHST1 MPZL2	2.98e-05	175	91	5	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRK4 HACE1 TBC1D25 ABCG2 CHST1	3.15e-05	177	91	5	8dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRK4 HACE1 TBC1D25 ABCG2 CHST1	3.15e-05	177	91	5	767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCell	E18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRK4 HACE1 TBC1D25 ABCG2 CHST1	3.15e-05	177	91	5	5ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCell	E18.5-Endothelial-Endothelial_lymphatic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRK4 HACE1 TBC1D25 ABCG2 CHST1	3.15e-05	177	91	5	ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZNF462 BMP1 HSPG2 CDH20 CDH19	3.15e-05	177	91	5	6b4fe717928814dafcd13090b1c90ea973938c6d
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EFHC2 MYO9B ENPP3 GATA2 CRLF2	3.15e-05	177	91	5	4a222234ca6cf28a34205c4bd675cd49d92b5b2e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RASIP1 HSPG2 ANO2 ADAMTS7 ABCG2	3.32e-05	179	91	5	8f9e538c822940785130297712b75131812a4603
ToppCell	critical-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZNF462 HSPG2 ADAMTS7 ENPP3 GATA2	3.50e-05	181	91	5	f0d81ae74d3f32979624a94b2ef93774831a7970
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASIP1 HSPG2 THBS1 GATA2 NID1	3.60e-05	182	91	5	3b4dbf61ca0fe50efe05449815630e301cb76630
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASIP1 HSPG2 THBS1 GATA2 NID1	3.60e-05	182	91	5	ab5761bf9af439231cd0f487b6467e372672a517
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HSPG2 ANO2 KCNT2 NID1 CDH19	3.60e-05	182	91	5	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS19 BMP1 HSPG2 NID1 AWAT2	3.69e-05	183	91	5	07ca2786e62eca9feecf5e54a11864a960f7641a
ToppCell	Transplant_Alveoli_and_parenchyma-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF462 EFHC2 ENPP3 GATA2 CRLF2	3.79e-05	184	91	5	bc394eaa441fcaffcc4ace062741bca1da229324
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 KCNT2 NID1 CDH19 SMTN	3.79e-05	184	91	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
Disease	Malignant neoplasm of breast	ADAMTS19 BMP1 THBS1 CDH20 KCNT2 B4GAT1 SEMA5B ZNF569 ABCG2 TTC3 ATP2A3 ANAPC5 HNRNPL SORL1	3.44e-06	1074	88	14	C0006142
Disease	Brody myopathy (implicated_via_orthology)	ATP2A1 ATP2A3	2.63e-05	3	88	2	DOID:0050692 (implicated_via_orthology)
Disease	retinal detachment	FAT3 CDH19	1.83e-04	7	88	2	EFO_0005773
Disease	coronary artery calcification	ZNF462 ADAMTS7 KCND2 ENPP3 CDH19 LRP1B ATP2A3	4.02e-04	450	88	7	EFO_0004723
Disease	Osteogenesis imperfecta type III (disorder)	BMP1 P3H1	4.75e-04	11	88	2	C0268362
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	CCN2 CRLF2	5.69e-04	12	88	2	C0023485
Disease	temporal arteritis	RSBN1 MICA	5.69e-04	12	88	2	EFO_1001209
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	PCSK1 CCN2 ABCG2 ATP2A1	9.97e-04	147	88	4	DOID:9352 (biomarker_via_orthology)
Disease	non-word reading	CDH20 SLC12A3 SORL1	1.07e-03	67	88	3	EFO_0005299
Disease	hyperglycemia (implicated_via_orthology)	PCSK1 HRH3	1.16e-03	17	88	2	DOID:4195 (implicated_via_orthology)
Disease	Stevens-Johnson syndrome, toxic epidermal necrolysis	MICA ADAM22	1.16e-03	17	88	2	EFO_0004276, EFO_0004775
Disease	essential hypertension (is_implicated_in)	SLC12A3 GRK4	1.30e-03	18	88	2	DOID:10825 (is_implicated_in)
Disease	epilepsy (implicated_via_orthology)	SLC12A3 KCNT2 LRP1B DYNC1H1	1.46e-03	163	88	4	DOID:1826 (implicated_via_orthology)
Disease	Osteogenesis imperfecta	BMP1 P3H1	1.78e-03	21	88	2	cv:C0029434
Disease	Nephritis, Tubulointerstitial	THBS1 SLC12A3	1.78e-03	21	88	2	C0041349
Disease	Intellectual Disability	ZNF462 LINS1 ASH1L PTPN23 ACTL6A DYNC1H1	2.23e-03	447	88	6	C3714756
Disease	Nephritis, Interstitial	THBS1 SLC12A3	2.33e-03	24	88	2	C0027707

Protein segments in the cluster

Peptide	Gene	Start	Entry
TELGYPSQQHYFNED	TDRD5	691	Q8NAT2
PAGTELTYDYNFHSF	ASH1L	2251	Q9NR48
LHGQEEQDQYFEFFP	B4GAT1	36	O43505
EYENFYADFGPLNLA	CDC14B	81	O60729
HYEFPNGYNCDFGAE	ACTL6A	286	O96019
GYHCEAYNNPADFFL	ABCG2	281	Q9UNQ0
FYDGNHTYLIEPEEN	ADAM22	161	Q9P0K1
NLHPRDYFDANPYFS	C4orf47	196	A7E2U8
TYFSPDFQLYSGRHE	AMOTL1	36	Q8IY63
YATPFAFHNYNGSNE	AASDH	1021	Q4L235
YNAFPVGSEYADFPH	CDADC1	366	Q9BWV3
AFFHQGYDLFSELGP	ACAP2	201	Q15057
NNIYEAAYPLHDGEY	ANO2	306	Q9NQ90
YLFALHDYDQSGQLD	CGREF1	76	Q99674
KDLYSHAQFGDNNYP	BMP1	871	P13497
HAAVDGDPDNYIAYY	DNAJC3	61	Q13217
FLYAEDGPHVNYSQL	ATP2A1	856	O14983
FVYDAEGPHINFYQL	ATP2A3	856	Q93084
DYNFINFHEDLSYGP	ADAMTS7	1066	Q9UKP4
PYFLLLQGYQDAQDF	RASIP1	381	Q5U651
QYGAYFHDDGFLAFP	HSPG2	4201	P98160
EHYIFYFAGETPEQA	RASA1	551	P20936
GDLFNLYLHQNYIDF	RAD17	446	O75943
FQDQNYGLHYEYTIP	ADAMTS19	886	Q8TE59
FEDFLPSHYNYLQFA	P3H1	296	Q32P28
AGAFAYLREHFPQAY	PTPN23	151	Q9H3S7
QHFYYDGELFLSQNL	MICA	131	Q29983
FNPDFAEAHYLSYLN	ANAPC5	246	Q9UJX4
FIYPFNYSGDHQQIS	LRP1B	3901	Q9NZR2
LENDSHDYIFYLNPA	LINS1	21	Q8NG48
INAEYPDSFGHYREA	MGAT2	211	Q10469
EAYDPQVGDYFIDHN	WWC1	61	Q8IX03
DHFFGYQYLNGVNPV	ALOXE3	271	Q9BYJ1
LGYDYLENAYVHFPQ	KIAA2026	461	Q5HYC2
PDEDQFYTVYHFNVG	EFHC2	141	Q5JST6
YAIFLYPEDGLQFHT	NID1	191	P14543
SYVNPDHLNYFRFAG	HACE1	631	Q8IYU2
YHPETQQYFFDRDPD	KCND2	76	Q9NZV8
GPEQFVFYYHIDPFQ	MPZL2	71	O60487
DFLNEFYAHPRLQDY	KCNT2	316	Q6UVM3
LTFHYRFNGDEAYDQ	CRLF2	56	Q9HC73
SFLDFAPHYFNYITN	PIKFYVE	1886	Q9Y2I7
DVFFNHLDSQGNPYY	GATA2	46	P23769
YSLDDNEYFFDRHPG	KCNB1	76	Q14721
PAYAFGETDLYDQHI	AWAT2	221	Q6E213
VSGPIFDYNYDGHFD	ENPP3	746	O14638
FDYNYDGHFDAPDEI	ENPP3	751	O14638
PPDFFYFSDYERHNA	FAM20C	296	Q8IXL6
GQHFYYSLAPEAANN	CDH20	526	Q9HBT6
HYNCPGDNDIFESLY	CCN2	326	P29279
DHYFLSDGLYVPEDQ	C5orf22	131	Q49AR2
NDHTPEFQQPLYDAY	FAT3	466	Q8TDW7
YVLQDDYGHFEINPN	FAT3	2121	Q8TDW7
NQGYFFFHLPDALEI	IL2RB	361	P14784
GYDNYMAHAFPQDEL	EDEM1	141	Q92611
QNPNSNYFGDVHFYD	MANBA	521	O00462
SSIPEGHCYAEFFYN	HRH3	181	Q9Y5N1
LQCYSFEHTYFGPFD	LYPD5	26	Q6UWN5
YAADNQIYIAGHPAF	HNRNPL	156	P14866
FFLDIYHNVLYENPN	DYNC1H1	3831	Q14204
FASPNGEQFYHYKDL	KLHDC4	141	Q8TBB5
HNYLRGEPFEEYQES	GRK4	151	P32298
PLEDFYLGTYHAVNN	SLC15A5	131	A6NIM6
PDFHYEFSYQIGNTS	PKD1L1	1221	Q8TDX9
QYYFVLPAGEHLDNY	PKD1L1	1246	Q8TDX9
LNINDHAPEFSQYYE	CDH19	461	Q9H159
EGAISPDFFNDYHLQ	KIFAP3	731	Q92845
GYIHPAQDDRTFYQF	KIF1A	1226	Q12756
GPGACDYHQDLYDDF	PTPRK	41	Q15262
ALPDSHSAQDFYENY	PHKG1	6	Q16816
EIHYSNFNNLPGVYD	MOXD2P	306	A6NHM9
YNEYFVFDFIGPQVH	FER1L6	126	Q2WGJ9
HGAAAYLPDFLDYFA	RSBN1	416	Q5VWQ0
DFSEHNCQPYYASDG	SCML1	186	Q9UN30
PDIHIDSYGENYLSF	SORL1	1751	Q92673
HADPDFYQYLQEAGA	TBC1D25	386	Q3MII6
DDFESPQAVYYFHPQ	ST8SIA5	266	O15466
DAFYPQHFLDEQGRF	CYP2G1P	61	Q6ZSU1
NQHLDVFYLFEPLYH	CHST1	81	O43916
FHYNPAQYDYDRDDV	THBS1	756	P07996
NHFYSDQPEIALRFY	TTC8	361	Q8TAM2
LQNPAEFYDNYYAQH	ZC3H6	591	P61129
GYFHRAEQVDPNFYS	RMDN1	246	Q96DB5
ELYSHAQFGDNNYPS	TLL2	901	Q9Y6L7
YDYFSQFLEEHGPLD	TTC3	1111	P53804
DYIGILHDAFDFNYG	SLC12A3	756	P55017
EGYDEFHNPLAYSSE	DHX38	331	Q92620
EVPFYYNELQSAFHL	SEMA5B	351	Q9P283
NSDFFPSRHNLYEYD	ZNF569	126	Q5MCW4
TLDNPYEYENSFNYH	ZNF140	436	P52738
YEKYHNQPEFDVFSQ	ZNF462	1596	Q96JM2
APAGSLFENHYEEDY	ZCWPW2	311	Q504Y3
ALVHNFFPEAFDYGQ	SMTN	836	P53814
QDEHPQEDGYYFLLQ	MYO9B	96	Q13459
FYDGENYLPVHLQGF	MYOG	16	P15173
SYDFNDNDHDPFPRY	PCSK1	186	P29120