Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglucosidase activity

KL SI LCT

3.50e-0515873GO:0015926
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNH1 KCNJ6 KCNJ11

5.20e-0517873GO:0099508
GeneOntologyMolecularFunctionthreonine-tRNA ligase activity

TARS3 TARS1

5.61e-053872GO:0004829
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

KL MAN2C1 SI LCT LYZ

8.75e-05103875GO:0004553
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNH2 KCNJ6 KCNJ11

2.42e-0428873GO:0005242
GeneOntologyMolecularFunctionbeta-glucosidase activity

KL LCT

2.78e-046872GO:0008422
GeneOntologyMolecularFunctionribosomal protein S6 kinase activity

RPS6KB1 RPS6KB2

3.89e-047872GO:0004711
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

KL MAN2C1 SI LCT LYZ

4.18e-04144875GO:0016798
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CATSPER1 KCNH1 KCNH2 KCNJ6 KCNJ11

5.35e-04152875GO:0022843
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNH1 KCNH2 KCNJ6 KCNJ11

1.03e-03102874GO:0005249
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CATSPER1 KCNH1 KCNH2 KCNJ6 KCNJ11

1.20e-03182875GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CATSPER1 KCNH1 KCNH2 KCNJ6 KCNJ11

1.26e-03184875GO:0022832
GeneOntologyMolecularFunctioncarboxypeptidase activity

AGBL2 ACE AGTPBP1

1.27e-0349873GO:0004180
GeneOntologyCellularComponentcell surface

EPHB6 OTOA VLDLR CD1C DUOX1 ACHE KCNH1 KCNH2 KCNJ6 RPS6KB1 MR1 CCR5 LCT ACE IL17RB

4.33e-0511118615GO:0009986
GeneOntologyCellularComponentaxolemma

KCNH1 KCNJ11 MAPK8IP3

8.47e-0521863GO:0030673
DomainRibosomal_S6_kinase

RPS6KB1 RPS6KB2

2.14e-052872IPR016238
DomainThrRS_core

TARS3 TARS1

6.42e-053872IPR033728
DomainThr-tRNA-ligase_IIa

TARS3 TARS1

6.42e-053872IPR002320
DomainGlyco_hydro_1_N_CS

KL LCT

1.28e-044872IPR033132
DomainGlyco_hydro_1_AS

KL LCT

1.28e-044872IPR018120
DomainGLYCOSYL_HYDROL_F1_2

KL LCT

2.13e-045872PS00653
DomainGLYCOSYL_HYDROL_F1_1

KL LCT

2.13e-045872PS00572
DomainGlyco_hydro_1

KL LCT

2.13e-045872PF00232
DomainGlyco_hydro_1

KL LCT

2.13e-045872IPR001360
DomainTGS

TARS3 TARS1

3.18e-046872IPR004095
DomainTGS

TARS3 TARS1

3.18e-046872PF02824
Domain-

EPHB6 PCSK5 CUL9 FBXO27

3.74e-04738742.60.120.260
DomainTGS-like

TARS3 TARS1

4.44e-047872IPR012676
DomaintRNA_SAD

TARS3 TARS1

4.44e-047872SM00863
DomaintRNA_SAD

TARS3 TARS1

4.44e-047872IPR012947
DomaintRNA_SAD

TARS3 TARS1

4.44e-047872PF07973
DomainThr/Ala-tRNA-synth_IIc_edit

TARS3 TARS1

5.90e-048872IPR018163
DomainPkinase_C

RPS6KB1 RPS6KB2 SGK2

6.76e-0437873IPR017892
DomainHGTP_anticodon

TARS3 TARS1

7.56e-049872PF03129
DomainPAS_9

KCNH1 KCNH2

9.42e-0410872PF13426
DomainGalactose-bd-like

EPHB6 PCSK5 CUL9 FBXO27

9.73e-0494874IPR008979
DomainPkinase_C

RPS6KB1 RPS6KB2 SGK2

9.83e-0442873PF00433
Domainaa-tRNA-synt_IIb

TARS3 TARS1

1.15e-0311872IPR002314
DomaintRNA-synt_2b

TARS3 TARS1

1.15e-0311872PF00587
Domain-

TARS3 TARS1

1.15e-03118723.40.50.800
DomainBeta-grasp_dom

TARS3 TARS1

1.88e-0314872IPR012675
DomainK_chnl_volt-dep_EAG/ELK/ERG

KCNH1 KCNH2

1.88e-0314872IPR003938
Domain-

TARS3 TARS1

1.88e-03148723.10.20.30
DomainAnticodon-bd

TARS3 TARS1

1.88e-0314872IPR004154
DomainGlycoside_hydrolase_SF

KL SI LCT

1.93e-0353873IPR017853
DomainAGC-kinase_C

RPS6KB1 RPS6KB2 SGK2

2.26e-0356873IPR000961
DomainAGC_KINASE_CTER

RPS6KB1 RPS6KB2 SGK2

2.26e-0356873PS51285
DomainS_TK_X

RPS6KB1 RPS6KB2 SGK2

2.26e-0356873SM00133
DomainK_chnl_inward-rec_Kir_cyto

KCNJ6 KCNJ11

2.47e-0316872IPR013518
DomainIRK

KCNJ6 KCNJ11

2.47e-0316872PF01007
Domain-

KCNJ6 KCNJ11

2.47e-03168722.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ6 KCNJ11

2.47e-0316872IPR016449
DomainGal_mutarotase_SF_dom

MAN2C1 SI

2.79e-0317872IPR011013
Domainaa-tRNA-synth_II

TARS3 TARS1

3.13e-0318872IPR006195
DomainAA_TRNA_LIGASE_II

TARS3 TARS1

3.13e-0318872PS50862
DomainPeptidase_M14

AGBL2 AGTPBP1

5.09e-0323872PF00246
DomainPeptidase_M14

AGBL2 AGTPBP1

5.09e-0323872IPR000834
Domain-

CD1C MR1

5.54e-03248723.30.500.10
DomainPAS-assoc_C

KCNH1 KCNH2

5.54e-0324872IPR000700
DomainMHC_I-like_Ag-recog

CD1C MR1

5.54e-0324872IPR011161
DomainPAS

KCNH1 KCNH2

6.00e-0325872PF00989
DomainEphrin_rec_like

EPHB6 PCSK5

6.00e-0325872SM01411
PathwayKEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY

VLDLR RPS6KB1 RPS6KB2

4.90e-0515693M47663
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

EPHB6 PCSK5 SETD1B KCNH1 KCNH2 RPS6KB1 RPS6KB2 RIOK3 KDM1B TARS1 STT3B SGK2

3.20e-07730881234857952
Pubmed

Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.

TARS3 TARS1

6.33e-06288237059185
Pubmed

Unique cerebellar phenotype combining granule and Purkinje cell loss: morphological evidence for weaver* pcd double mutant mice.

KCNJ6 AGTPBP1

6.33e-0628822027034
Pubmed

Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.

RPS6KB1 RPS6KB2

6.33e-06288233003310
Pubmed

Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods.

KCNH1 KCNH2

6.33e-06288219671703
Pubmed

Serotonin-immunoreactivity in the cerebellum of two neurological mutant mice and the corresponding wild-type genetic stocks.

KCNJ6 AGTPBP1

6.33e-0628821781951
Pubmed

Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis.

RPS6KB1 RPS6KB2

6.33e-06288227493124
Pubmed

hERG channel blockade by externally applied quaternary ammonium derivatives.

KCNH1 KCNH2

6.33e-06288221320466
Pubmed

Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics.

KCNH1 KCNH2

6.33e-06288220126398
Pubmed

K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons.

KCNJ6 KCNJ11

6.33e-06288216299504
Pubmed

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.

RPS6KB1 RPS6KB2

6.33e-06288217550782
Pubmed

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

RPS6KB1 RPS6KB2

6.33e-06288218174371
Pubmed

Solanine inhibits proliferation and promotes apoptosis of the human leukemia cells by targeting the miR-16/Bcl-2 axis.

BCL2 GDE1

6.33e-06288232862612
Pubmed

Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2.

CCR5 BCL2

6.33e-06288212751031
Pubmed

Modulation of GABA(A) receptor subunit mRNA levels in olivocerebellar neurons of purkinje cell degeneration and weaver mutant mice.

KCNJ6 AGTPBP1

6.33e-06288210800965
Pubmed

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.

RPS6KB1 RPS6KB2

6.33e-0628829822608
Pubmed

Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses.

IL1R2 LYZ

6.33e-06288228235865
Pubmed

Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer.

RPS6KB1 RPS6KB2

6.33e-06288220953835
Pubmed

Plasticity of GABAergic terminals in Deiters' nucleus of weaver mutant and normal mice: a quantitative light microscopic study.

KCNJ6 AGTPBP1

6.33e-0628821446244
Pubmed

Klotho sensitivity of the hERG channel.

KL KCNH2

6.33e-06288223603386
Pubmed

Metabolic control by S6 kinases depends on dietary lipids.

RPS6KB1 RPS6KB2

6.33e-06288222412899
Pubmed

Molecular biology of aging.

KL BCL2

6.33e-0628829988222
Pubmed

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.

RPS6KB1 RPS6KB2

6.33e-06288218758466
Pubmed

A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

TARS3 TARS1

6.33e-06288229579307
Pubmed

The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel.

KCNH2 BCL2

6.33e-06288222107967
Pubmed

A family of potassium channel genes related to eag in Drosophila and mammals.

KCNH1 KCNH2

6.33e-0628828159766
Pubmed

Functions and regulation of the 70kDa ribosomal S6 kinases.

RPS6KB1 RPS6KB2

6.33e-06288220932932
Pubmed

Lesion-specific pattern of immunocytochemical distribution of growth-associated protein B-50 (GAP-43) in the cerebellum of Weaver and PCD-mutant mice: lack of B-50 involvement in neuroplasticity of Purkinje cell terminals?

KCNJ6 AGTPBP1

6.33e-0628827932867
Pubmed

Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.

RPS6KB1 RPS6KB2

6.33e-06288227438654
Pubmed

Gene amplification of ribosomal protein S6 kinase-1 and -2 in gastric cancer.

RPS6KB1 RPS6KB2

6.33e-06288223393338
Pubmed

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.

RPS6KB1 RPS6KB2

6.33e-06288220080710
Pubmed

Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis.

TNFSF11 BCL2

6.33e-06288235183115
Pubmed

Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice.

BCL2 AGTPBP1

6.33e-0628827563251
Pubmed

Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.

RPS6KB1 RPS6KB2

6.33e-06288212529391
Pubmed

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.

RPS6KB1 RPS6KB2

6.33e-0628829804755
Pubmed

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.

RPS6KB1 RPS6KB2

6.33e-06288215060135
Pubmed

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation.

RPS6KB1 RPS6KB2

6.33e-06288218846252
Pubmed

The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance.

KL BCL2

1.90e-05388231908069
Pubmed

Calbindin D-28k in the lateral vestibular nucleus of mutant mice as a tool to reveal Purkinje cell plasticity.

KCNJ6 AGTPBP1

1.90e-0538828177535
Pubmed

Mechanism of Bcl-2 and Bcl-X(L) inhibition of NLRP1 inflammasome: loop domain-dependent suppression of ATP binding and oligomerization.

NLRP1 BCL2

1.90e-05388219223583
Pubmed

mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia.

RPS6KB1 RPS6KB2

1.90e-05388219535330
Pubmed

The response of the QT interval to the brief tachycardia provoked by standing: a bedside test for diagnosing long QT syndrome.

KCNH1 KCNH2

1.90e-05388220116193
Pubmed

Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism.

RPS6KB1 RPS6KB2

1.90e-05388215589845
Pubmed

Pro-thyrotropin-releasing hormone concentrations in the brain of ataxic mice.

KCNJ6 AGTPBP1

1.90e-0538822123001
Pubmed

Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.

RPS6KB1 RPS6KB2

1.90e-05388218006852
Pubmed

Expression of c-kit, a proto-oncogene of the murine W locus, in cerebella of normal and neurological mutant mice: immunohistochemical and in situ hybridization analysis.

KCNJ6 AGTPBP1

1.90e-0538821282111
Pubmed

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

KL BCL2

1.90e-05388229849149
Pubmed

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.

RPS6KB1 RPS6KB2

1.90e-05388215071500
Pubmed

Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum.

KCNJ6 AGTPBP1

1.90e-05388219200061
Pubmed

Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.

RPS6KB1 RPS6KB2

1.90e-05388232054043
Pubmed

Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.

KL BCL2

1.90e-05388231984794
Pubmed

mTORC1 directly phosphorylates and regulates human MAF1.

RPS6KB1 RPS6KB2

1.90e-05388220516213
Pubmed

Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2.

BCL2 LYZ

1.90e-05388218988889
Pubmed

Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.

CCR5 LYZ

1.90e-05388232001710
Pubmed

Activation of dimeric glucocorticoid receptors in osteoclast progenitors potentiates RANKL induced mature osteoclast bone resorbing activity.

TNFSF11 LYZ

1.90e-05388227596806
Pubmed

DNA fragmentation and activation of c-Jun in the cerebellum of mutant mice (weaver, Purkinje cell degeneration).

KCNJ6 AGTPBP1

1.90e-0538828541477
Pubmed

Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy.

KCNJ6 AGTPBP1

1.90e-0538823619071
Pubmed

Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin.

MR1 LYZ

1.90e-05388237595566
Pubmed

mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice.

RPS6KB1 RPS6KB2

1.90e-05388218316404
Pubmed

Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.

DUOX1 LYZ

1.90e-05388235654836
Pubmed

Vestibular ganglion neurons survive the loss of their cerebellar targets.

KCNJ6 AGTPBP1

1.90e-0538829926858
Pubmed

OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.

RPS6KB1 LYZ

1.90e-05388232601203
Pubmed

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

RPS6KB1 RPS6KB2

1.90e-05388223318442
Pubmed

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response.

RPS6KB1 RPS6KB2

3.79e-05488220657550
Pubmed

Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin.

KL TNFSF11

3.79e-05488215564564
Pubmed

The type 1 insulin-like growth factor receptor (IGF-IR) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy.

RPS6KB1 RPS6KB2

3.79e-05488222087027
Pubmed

S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.

RPS6KB1 RPS6KB2

3.79e-05488221633171
Pubmed

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

KCNJ11 LCT

3.79e-05488217020404
Pubmed

Association of 1166A>C AT1R, -1562C>T MMP-9, ACE I/D, and CCR5Δ32 Polymorphisms with Abdominal Aortic Aneurysm in Croatian Patients.

CCR5 ACE

3.79e-05488227533781
Pubmed

Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.

SI LYZ

3.79e-05488228860595
Pubmed

PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.

RPS6KB1 RPS6KB2

3.79e-05488225762659
Pubmed

NeuN, a neuronal specific nuclear protein in vertebrates.

KCNJ6 AGTPBP1

3.79e-0548821483388
Pubmed

LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.

CCR5 LYZ

3.79e-05488237442140
Pubmed

RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.

TNFSF11 LYZ

3.79e-05488228438834
Pubmed

PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis.

BCL2 PLRG1

3.79e-05488219307306
Pubmed

Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo.

RPS6KB1 RPS6KB2

3.79e-05488219961954
Pubmed

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

RPS6KB1 RPS6KB2

3.79e-05488221444676
Pubmed

Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals.

RPS6KB1 RPS6KB2

3.79e-05488219289497
Pubmed

Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain.

KCNH1 KCNH2

3.79e-05488224587194
Pubmed

ZRF1 is a novel S6 kinase substrate that drives the senescence programme.

RPS6KB1 RPS6KB2

3.79e-05488228242756
Pubmed

Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs).

AGBL2 AGTPBP1

3.79e-05488223085998
Pubmed

[Elevated immunoreactive-somatostatin levels in the brain of ataxic mutant mice].

KCNJ6 AGTPBP1

3.79e-0548822901364
Pubmed

Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum.

KCNJ6 AGTPBP1

3.79e-0548822707487
Pubmed

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

RPS6KB1 RPS6KB2

3.79e-05488216763566
Pubmed

Ataxia-ameliorating effects of YM-14673, a potent analog of thyrotropin releasing hormone, in ataxic mutant mice.

KCNJ6 AGTPBP1

3.79e-0548828013566
Pubmed

Cellular distribution of the RNA transcripts of a newly discovered gene in the brain of normal, weaver, Purkinje cell degeneration and reeler mutant mice as evidenced by in situ hybridization histochemistry.

KCNJ6 AGTPBP1

3.79e-0548828326827
Pubmed

Fibroblast growth factor 23 and 25(OH)D levels are related to abdominal obesity and cardiovascular risk in patients with polycystic ovarian syndrome.

KL TNFSF11

3.79e-05488231709849
Pubmed

GABAA/benzodiazepine receptor alpha 6 subunit mRNA in granule cells of the cerebellar cortex and cochlear nuclei: expression in developing and mutant mice.

KCNJ6 AGTPBP1

3.79e-0548828132866
Pubmed

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

TNFSF11 LYZ

3.79e-05488228287403
Pubmed

Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.

KCNJ6 KCNJ11

3.79e-05488210022826
Pubmed

mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss.

VLDLR LYZ

3.79e-05488228591574
Pubmed

The Purkinje cell class may extend beyond the cerebellum.

KCNJ6 AGTPBP1

3.79e-0548822077109
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

EPHB6 NOP58 RTTN MRPS14 USP40 CUL9 AGTPBP1 DNAH1

3.83e-0549688831343991
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

NOP58 SETD1B WNT2 NLRP1 BCL2 IL17RB

5.01e-0525788630945288
Pubmed

Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.

KCNH2 KCNJ11

6.30e-05588228464250
Pubmed

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection.

RPS6KB1 RPS6KB2

6.30e-05588221501832
Pubmed

RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice.

TNFSF11 LYZ

6.30e-05588227733688
Pubmed

A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia?

ACE SDHC

6.30e-05588219768395
Pubmed

Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo.

CCR5 ACE

6.30e-05588219129082
Pubmed

The mTOR pathway negatively controls ATM by up-regulating miRNAs.

RPS6KB1 RPS6KB2

6.30e-05588223818585
ToppCelldistal-2-Hematologic-EREG+_Dendritic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD1C MB21D2 IL1R2 GNA15 CCR5 BCL2 LYZ

1.30e-071978876fcca7c071e35786b715adeb18be317d34315d7e
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA ARFGEF3 FAT3 NAV3 SFI1 DNAH1

1.77e-061848862cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA ARFGEF3 FAT3 NAV3 SFI1 DNAH1

1.77e-06184886ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA ARFGEF3 FAT3 NAV3 SFI1 DNAH1

1.77e-061848862b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 KCNJ6 CUL9 SI IL17RB NUTM2G

1.83e-06185886d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCelldistal-Hematologic-EREG+_Dendritic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD1C MB21D2 IL1R2 GNA15 BCL2 LYZ

2.55e-06196886c17bb7b3992bfec194bfa310f201a5c64b35868e
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFSF11 MTERF1 MR1 FBXO27 IL17RB

1.60e-05159885e967b557fe6ae4879d36f62c0297cbf6a2ad1ce9
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFSF11 MTERF1 MR1 FBXO27 IL17RB

1.60e-051598859db971130509c62d439e0cab16588a4d994d7aa0
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNJ6 FAT3 NAV3 BCL2

1.75e-051628859a18286e361e1dd18e6f943ce27db58b199fb6e4
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNJ6 FAT3 NAV3 BCL2

1.75e-051628853395e4dffdb9304d157c325e1fc0f12b433c7bd3
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNJ6 FAT3 NAV3 BCL2

1.75e-051628859522af31f6b2f3cb81b6b84bd08353eea504d1d6
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNJ6 FAT3 NAV3 BCL2

1.75e-0516288540265af9b36fd144a8577b8dacccd4fc0888a593
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

KCNH1 KCNH2 FAT3 NAV3 BCL2

2.47e-051748857e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 DUOX1 KCNH1 WNT2 AGBL2

2.75e-051788855fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCellPCW_05-06-Immune_Lymphocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CD1C TNFSF11 GNA15 CCR5 LYZ

2.98e-05181885bd99c5849bb4979c891898312cb9f602c6831b23
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD1C IL1R2 ACHE LYZ GLTPD2

3.06e-051828859a68d3bd1cc9139de9e9e711c249d47ade826bb1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD1C IL1R2 ACHE LYZ GLTPD2

3.06e-05182885d57d18732aa6fb7b2d430601568f9ba525ac6e3c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD1C IL1R2 ACHE LYZ GLTPD2

3.06e-05182885c3fb1460160744144aa31afc76c0a4d42ebdeb91
ToppCell3'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 SI LCT ACE GLTPD2

3.22e-05184885ed7a8e79e5723a5f5a03f542203d9e50bdef5f50
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KCNH1 KCNH2 FAT3 CLDN20 BCL2

3.66e-051898856011b747e27d61d222380a7bffdd921a68e9b657
ToppCellcritical-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KCNH1 KCNH2 FAT3 NAV3 BCL2

3.76e-0519088505a2c3549b68f49081723bf35db14974274419d5
ToppCellControl-Myeloid-cDC2|World / Disease state, Lineage and Cell class

CD1C MB21D2 IL1R2 GNA15 BCL2

3.85e-0519188511dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNH1 KCNH2 FAT3 NAV3 BCL2

3.85e-051918858f4637e801554e2343b974fe7794f01dd2151418
ToppCellCOPD-Myeloid-cDC2|COPD / Disease state, Lineage and Cell class

WDR74 CD1C MB21D2 IL1R2 GNA15

3.85e-051918852af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCellCOPD-Myeloid-cDC2|World / Disease state, Lineage and Cell class

WDR74 CD1C MB21D2 IL1R2 GNA15

3.85e-051918854e4887175200a57e1b041f2f131e3df774df3509
ToppCellCOPD-Myeloid-cDC2|Myeloid / Disease state, Lineage and Cell class

WDR74 CD1C IL1R2 GNA15 BCL2

3.95e-05192885984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell10x5'-Liver-Myeloid_Dendritic|Liver / Manually curated celltypes from each tissue

CD1C IL1R2 GNA15 FBXO27 LYZ

4.15e-05194885e6391bc7073831847c469ef0b0c437118e1f151f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD1C IL1R2 GNA15 BCL2 LYZ

4.25e-051958859c6bed8414633813e1655bbeaab682fb296958a9
ToppCelldistal-Hematologic-EREG+_Dendritic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD1C MB21D2 IL1R2 GNA15 LYZ

4.36e-0519688514c6870d125fc2bdacf4199883399cec0dd3f569
ToppCell390C-Myeloid-Dendritic|390C / Donor, Lineage, Cell class and subclass (all cells)

CD1C IL1R2 ACHE GNA15 LYZ

4.46e-05197885424526c94b9a73c1c28ddc65dfba53aba5c6b2d2
ToppCell5'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 SI LCT ACE LYZ

4.57e-051988858d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SGMS2 CATSPER1 IL1R2 GNA15 LYZ

4.57e-05198885dc59442e6a5127d3071a036c206732a21e456a17
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD1C IL1R2 GNA15 BCL2 LYZ

4.57e-051988854682f6e7b18b3fcc4066fb448f9756c32dce0be4
ToppCellLPS_only-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_only / Treatment groups by lineage, cell group, cell type

VLDLR ZNF789 CUL9 NLRP1 GNA15

4.57e-05198885d205dfcfe1f20e1e21bf84759e723d9e6e610a5c
ToppCelltumor_Lung-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

CD1C DUOX1 IL1R2 GNA15 BCL2

4.57e-05198885edd8ad006c4c7516491e52cc8adad20297837e5b
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CD1C CATSPER1 IL1R2 GNA15 LYZ

4.57e-05198885115f564af8d7b89ac0331d3831faaef694043fd4
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 SI LCT ACE GLTPD2

4.57e-051988856e6af8fad09f8e48b3f2ce463d5773b6a69864d1
ToppCell5'-Adult-SmallIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 SI LCT ACE LYZ

4.68e-05199885a5fffe381be1ba7d192b68d1d3937ce47663658e
ToppCellSepsis-Bac-SEP-Myeloid-tDC|Bac-SEP / Disease, condition lineage and cell class

VLDLR CD1C ZNF789 POGK LCLAT1

4.68e-05199885a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD1C IL1R2 GNA15 BCL2 FBXO27

4.68e-051998856fc8c321e2ddd802b9c8edfe16e006c7d4d862fc
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IL1R2 GNA15 FBXO27 LYZ SLC7A14

4.68e-0519988526ea06960e8ea061a71756750b84489609f78162
ToppCelldistal-Hematologic-Myeloid_Dendritic_Type_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD1C IL1R2 GNA15 BCL2 NUTM2G

4.68e-0519988578e70852acda95d2c770cdd539a46b291f929a78
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 SI LCT ACE GLTPD2

4.68e-0519988501c2721bc82cd672e9477029b4a7ecc77e2f1b00
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-mDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

1.36e-04132884f8e2ba53063007d7507f1837ad669b0e4333cd23
ToppCellmetastatic_Brain-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

CD1C IL1R2 KCNH2 LYZ

1.90e-041448846f1158c85e1d50ef6f2c67abdb2dc855a9786b9a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC|GW10 / Sample Type, Dataset, Time_group, and Cell type.

SGMS2 ACHE KIAA1958 FBXO27

2.28e-041518844533bccc996395f74b16af939ce79b6fe253c073
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related|GW10 / Sample Type, Dataset, Time_group, and Cell type.

SGMS2 ACHE KIAA1958 FBXO27

2.28e-04151884edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_3|390C / Donor, Lineage, Cell class and subclass (all cells)

OTOA CCR5 ACE LYZ

2.34e-04152884f717aae4882e9b67e5e40f4ef5b0d35f74a89165
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NOP58 IL1R2 NAV3 CUL9

2.46e-04154884b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCellControl-Epithelial-Ionocyte|Epithelial / Disease state, Lineage and Cell class

ACHE KCNH1 FAT3 BCL2

2.52e-041558844b9369b203a4d7071c56d3d8e6b450e9a0121c41
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

CD1C DUOX1 SMPD2 LRTM2

2.78e-04159884b3c52908cd24bbf851fac69db3850fc7f53c2092
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IL1R2 GNA15 LYZ RABGGTA

2.98e-0416288488576622af741cf5f754e328bd6d53385ef53be6
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TNFSF11 IL1R2 FBXO27 IL17RB

3.06e-04163884476e94e1d132eaaecb9e376bd32748a75ad22081
ToppCellInfluenza_Severe-cDC|World / Disease group and Cell class

GPR161 CD1C KCNH2 GNA15

3.13e-04164884c984228f73b9aa1aaf948541f64f41ed874770cd
ToppCellBac-SEP-Myeloid-tDC|Bac-SEP / Disease, Lineage and Cell Type

VLDLR CD1C ZNF789 LCLAT1

3.20e-041658848728f927502e56f2768b4224e9111939d3d7815a
ToppCell10x5'v1-week_14-16-Lymphocytic_NK-T_NK-NK_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GNA15 BCL2 IL17RB FER1L6

3.27e-0416688405d3e7f441089d788a192d7fa1ec5c302d1ca202
ToppCellIonocyte-iono-3|World / Class top

KL TMEM186 COX15 ACE

3.27e-041668849c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-mDC|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

3.43e-041688842dca1c4a33b6da9357fa3b2a523af19baab1c21c
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

3.58e-041708843cbeea6bfa500928c413b1c6129f6dedc769cd1e
ToppCell(7)_MNP-(7)_DC_activated|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ACHE KCNH2 FAT3 FBXO27

3.58e-041708844ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-CD1c+_DCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

CD1C GNA15 LRTM2 LYZ

3.58e-04170884403b6b749d70d845838dcda7daf99971b50792a2
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 GNA15 SLC7A14 IL17RB

3.75e-04172884ce444463f69bbb05c933615a0f1f43ddde3eee1c
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 GNA15 SLC7A14 IL17RB

3.75e-041728842c993a93ac91dcf6061eec001f51f8cccb6ee264
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells-mDC|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

3.75e-04172884cc0e2a45fa74ee19e41612c3615729462474003a
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 KCNJ6 KCNJ11 NUTM2G

3.83e-0417388446ed379571385684145b5cb6dd4ae340ac546e64
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB6 GNA15 SLC7A14 IL17RB

3.91e-0417488433386750842c47ad7e7286d0f26a556da1a2de02
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

WDR74 IL1R2 LYZ AGTPBP1

3.91e-04174884eaaf17a06efc09ed4752b449827b1f0f424d3dad
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB6 GNA15 SLC7A14 IL17RB

3.91e-041748849344d4e76d7d9429aea87d3c0b98246200d16014
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 KCNJ6 KCNJ11 SLC7A14

4.00e-04175884c031da47ca63d1133e13530cbf779df9435e22cb
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CD1C IL1R2 LYZ NUTM2G

4.08e-04176884a31d7532f8c055d4e62bbaa78d819f2495bfee00
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Mast_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CATSPER1 KCNH2 CLDN20 GNA15

4.08e-0417688401ae63366f0a25f46d3c8a3596e0dffdeba54a58
ToppCellCaecum-Dendritic_cell-cDC1|Dendritic_cell / Region, Cell class and subclass

EMC1 SETD1B SFI1 RABGGTA

4.08e-0417688407cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

4.08e-04176884f3bbe8c1a8d132705eac360cf531261271d84588
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 KCNJ6 KCNJ11 SI

4.17e-041778848dbef0005095c01a806d8c7f723dc48a4650efec
ToppCell367C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ACHE FBXO27 RNF180 SGK2

4.17e-04177884a0ff337f11bdb11959ac71805ff94be6b4ec1083
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNH1 KCNH2 FAT3 CLDN20

4.17e-0417788499500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCellnormal_Lung-Myeloid_cells-CD163+CD14+_DCs|normal_Lung / Location, Cell class and cell subclass

CD1C MB21D2 IL1R2 LYZ

4.26e-04178884b6dacaad09bf4384d0d4c926fbf769e74a8ec9a9
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SGMS2 FAT3 TRIM17 RNF180

4.26e-04178884e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 ACHE FAT3 DNAH1

4.35e-04179884479116ac65488c60104a053530830763ec1f95b2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 ACHE FAT3 DNAH1

4.35e-041798841dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFSF11 CATSPER1 GNA15 IL17RB

4.35e-04179884b8bc03f60a7ac76ea6ee90d0512f0dc1d1d2a087
ToppCellControl-Myeloid-Monocytes,_Macrophages|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

4.35e-04179884a79a244bf8ecc333d034b2eb2de554d3310ca6de
ToppCellControl-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

4.35e-04179884c4ff8b191ed0f6dc2dd784869f6f2c62e170a7db
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB6 ACHE FAT3 DNAH1

4.35e-0417988469a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 KCNJ6 LRTM2 SLC7A14

4.35e-041798848ce5000088b727783a0619baa16a2cd036d21f54
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNH1 KCNH2 FAT3 CLDN20

4.45e-041808848af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

VLDLR SETD1B IL17RB DNAH1

4.45e-0418088462511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNH2 FAT3 LRTM2

4.45e-041808845286e66ff6b7154390b3e9c189704a71d56bc89c
ToppCelldroplet-Kidney-nan-18m-Epithelial-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NDUFA13 GPR161 KL AGBL2

4.45e-04180884cd743f81838ba210e5bb63fe0870918d7d2b0112
ToppCellfacs-SCAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUOX1 IL1R2 WNT2 ACE

4.45e-041808846c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCellControl-Myeloid-Dendritic_cells|Control / group, cell type (main and fine annotations)

CD1C MB21D2 IL1R2 BCL2

4.45e-0418088425ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCellCV-Severe-4|Severe / Virus stimulation, Condition and Cluster

TARS3 TNFSF11 GNA15 GDE1

4.45e-04180884cf84a01e6a33e5d27ad7be1d9069a0370b5116d1
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNH2 FAT3 LRTM2

4.45e-041808842b6b295b5c21b829828afae9ab4c3eb9233f6f45
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCNH1 KCNH2 FAT3 LRTM2

4.45e-04180884bf587387145a2b5e83766fbccf76eecc6d5e8241
ToppCellControl-Myeloid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD1C NLRP1 GNA15 LYZ

4.54e-0418188425170e5285996cc80337d5f86a0255569861ae77
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TARS3 BCL2 SSR3 RIC1

4.63e-04182884626aabfd9ac662c1d189f7c4b660482914d9e669
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

VLDLR SETD1B IL17RB DNAH1

4.63e-0418288403992d0ae519795239e4f2cc8e63f33c4482de6a
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD1c+_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

CD1C IL1R2 GNA15 LYZ

4.63e-04182884551d301adfb4d5046c5f60f6996450621b04e9b2
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TARS3 BCL2 SSR3 RIC1

4.63e-04182884a00abff41c12b71d5860c494b8c722d649fd5f36
ToppCellCV-Severe-4|CV / Virus stimulation, Condition and Cluster

TARS3 TNFSF11 GNA15 GDE1

4.63e-04182884c19bbc43d97c426aec37414f46f667a19b62a257
DrugTrifluoperazine

TNFSF11 ACHE KCNH2 RPS6KB1 BCL2

2.28e-0735885ctd:D014268
DrugCarbachol

ACHE KCNJ6 RPS6KB1 BCL2 LYZ

2.51e-0656885ctd:D002217
DrugBromperidol [10457-90-6]; Down 200; 9.6uM; HL60; HG-U133A

UBR2 EMC1 TM9SF4 MR1 RIOK3 NLRP1 MAPK8IP3

1.07e-051958871723_DN
Drug3-fluorotyrosine

MR1 SI STT3B

1.20e-0512883CID000092100
Drugdesmethylastemizole

KCNH1 KCNH2

1.48e-052882ctd:C040463
Drugglycylmethionylglycine

LYZ STT3B

1.48e-052882CID003016679
Drugxaliproden

ACHE KCNH2

1.48e-052882ctd:C462299
DrugBenperidol

KCNH1 KCNH2

1.48e-052882ctd:D001544
Drugmatrine

CATSPER1 KCNH2 BCL2

1.97e-0514883ctd:C034244
Drugp-nitrophenyl

KL MAN2C1 ACHE SI LCT LYZ

2.21e-05146886CID000007416
Drughex-2-ene

ACHE KCNJ6 LCT

3.01e-0516883CID000019966
Diseaseamino acid metabolic disorder (implicated_via_orthology)

TARS3 TARS1

4.90e-054852DOID:9252 (implicated_via_orthology)
DiseaseDevelopmental Academic Disorder

KL ACHE BCL2

7.99e-0529853C1330966
DiseaseLearning Disorders

KL ACHE BCL2

7.99e-0529853C0023186
DiseaseLearning Disturbance

KL ACHE BCL2

7.99e-0529853C0751263
DiseaseAdult Learning Disorders

KL ACHE BCL2

7.99e-0529853C0751262
DiseaseLearning Disabilities

KL ACHE BCL2

7.99e-0529853C0751265
Diseasemonocyte measurement

KCNJ6 RPS6KB1 LYZ METTL17

9.45e-0582854EFO_0803547
Diseaseneutrophil count

UBR2 VLDLR CD1C IL1R2 MRPS14 PCDHA8 RIOK3 GNA15 BCL2 AGBL2 LCT LYZ SDHC

1.57e-0413828513EFO_0004833
Diseaseinterleukin 9 measurement

KLHDC1 KCNJ6 RTTN

2.62e-0443853EFO_0008192
DiseaseMemory Loss

KL ACHE BCL2

2.62e-0443853C0751295
DiseaseAge-Related Memory Disorders

KL ACHE BCL2

2.62e-0443853C0751292
DiseaseMemory Disorder, Spatial

KL ACHE BCL2

2.62e-0443853C0751294
DiseaseMemory Disorder, Semantic

KL ACHE BCL2

2.62e-0443853C0751293
DiseaseMemory Disorders

KL ACHE BCL2

2.62e-0443853C0025261
DiseaseMemory impairment

KL ACHE BCL2

2.81e-0444853C0233794
Diseasealcohol dependence (implicated_via_orthology)

RPS6KB1 RPS6KB2

2.91e-049852DOID:0050741 (implicated_via_orthology)
DiseaseMitochondrial Diseases

NDUFA13 COX15 SDHC

3.86e-0449853C0751651
Diseasehypertension (biomarker_via_orthology)

KL KCNJ11 CCR5 BCL2 ACE

5.13e-04227855DOID:10763 (biomarker_via_orthology)
DiseaseAlzheimer's disease (implicated_via_orthology)

CCR5 BCL2 ACE

6.03e-0457853DOID:10652 (implicated_via_orthology)
DiseaseHypercalcemia

KL TNFSF11

6.27e-0413852C0020437
DiseaseMilk-Alkali Syndrome

KL TNFSF11

6.27e-0413852C0026141
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

KL KCNJ11 CCR5 BCL2

8.75e-04147854DOID:9352 (biomarker_via_orthology)
Diseasesarcoidosis (is_implicated_in)

CCR5 ACE

9.59e-0416852DOID:11335 (is_implicated_in)
Diseasetype 1 diabetes mellitus (is_marker_for)

ACHE CCR5 ACE

1.19e-0372853DOID:9744 (is_marker_for)
Diseaseend stage renal disease (implicated_via_orthology)

BCL2 ACE

1.51e-0320852DOID:783 (implicated_via_orthology)
DiseaseNerve Degeneration

KCNJ6 BCL2 AGTPBP1

1.80e-0383853C0027746
Diseasedilated cardiomyopathy (biomarker_via_orthology)

RPS6KB1 BCL2

1.82e-0322852DOID:12930 (biomarker_via_orthology)
DiseaseKidney Diseases

PCSK5 KL ACE

2.12e-0388853C0022658
DiseaseCardiac Arrhythmia

KCNH2 ACE

2.36e-0325852C0003811
Diseasecolon adenocarcinoma (is_marker_for)

PCSK5 BCL2

2.36e-0325852DOID:234 (is_marker_for)
Diseasecorpus collosum mid-posterior volume measurement

VLDLR AGBL2

2.36e-0325852EFO_0010300
DiseaseLeft Ventricular Hypertrophy

RPS6KB1 ACE

2.36e-0325852C0149721
Diseasewaist-hip ratio

PCSK5 WNT2 KCNJ6 MRPS14 NAV3 CLDN20 CUL9 RIOK3 BCL2 SSR3

2.74e-0312268510EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
ERQWKAEFHRWSSYM

ACHE

581

P22303
DWSLIYMDSRAQGAW

CATSPER1

631

Q8NEC5
SYAMLLFAWEGWHNA

ACE

181

P12821
LDAWYGARDWALNHL

ACTR5

531

Q9H9F9
WAHYAAAQWDFGNTM

CCR5

86

P51681
WWIRMGTDICYYKNH

AGTPBP1

796

Q9UPW5
QLHGLWMDCTWYSTG

CLDN20

46

P56880
KINSMSWGAEGYHLW

RIC1

361

Q4ADV7
MAGNFWQSSHYLQWI

CCNC

1

P24863
RFDGWYNNLMEHRWG

DUOX1

31

Q9NRD9
SWVSAEHLWVLGRYM

OTOA

251

Q7RTW8
LNNYIMRCREWYGWH

NOP58

176

Q9Y2X3
MDYHWRGELGSWRLL

PCDHA8

1

Q9Y5H6
WMCLAKWESGYNTRA

LYZ

46

P61626
AVAQSWLMENHFWDG

MB21D2

246

Q8IYB1
EHYWSLVAMAAWERR

GLTPD2

146

A6NH11
MWLGAQNGWLYVHSA

MAPK8IP3

971

Q9UPT6
WWLIAYIRGDMDHIE

KCNJ6

111

P48051
ATWVLVAGIYLMWRH

IL17RB

301

Q9NRM6
AHWLACIWYAIGNME

KCNH2

561

Q12809
WAMQAAAYIFIHRKW

LCLAT1

161

Q6UWP7
FAMAWWLIAFAHGDL

KCNJ11

86

Q14654
NWEFMTIHCWGERAA

PCSK5

551

Q92824
LVWRYGFQSLRMHMW

PCYOX1

141

Q9UHG3
ADNGTMHLWDWRTGY

PLRG1

431

O43660
MHLWDWRTGYNFQRV

PLRG1

436

O43660
AWDLALHTWEQMGLR

NLRP1

66

Q9C000
EGSRVWFMDLWNYSL

NAV3

2251

Q8IVL0
GTLIYGHWSIMKWNR

NDUFA13

41

Q9P0J0
FGLAAHWMACIWYSI

KCNH1

386

O95259
MRSGHNRAVDWWSLG

RPS6KB1

266

P23443
NRAVDWWSLGALMYD

RPS6KB1

271

P23443
RGYVAWSLMDNFEWL

LCT

1311

P09848
YAAAMQWLWRDAGIR

GNA15

131

P30679
HRYGWMTEDLMQDWL

POGK

436

Q9P215
GMAQARWWATFASYV

SMPD2

316

O60906
ELLRQWMDHGGWYDR

DNAH1

2311

Q9P2D7
LLDWSMHNILWYLCG

GDE1

256

Q9NZC3
LRVLEVSNHWWYSML

KDM1B

191

Q8NB78
DIILYWGHHFSMNWI

CD1C

291

P29017
WLRRSHKDHSYWDMA

ARFGEF3

1511

Q5TH69
YHTWNGIRHLMWDLG

SDHC

126

Q99643
AYHWDTSDWMPGARL

FAT3

4351

Q8TDW7
DFHSCLGWMQWRGLS

AGBL2

96

Q5U5Z8
ARFEVWAHRWMDLSE

MAN2C1

846

Q9NTJ4
WAHRWMDLSEHGFGL

MAN2C1

851

Q9NTJ4
WMCVAAWHREPGYTA

GPR161

176

Q8N6U8
IWTYDIDSGLWRMHL

KLHDC1

46

Q8N7A1
MNDLHYLNLDTWTWS

KLHDC1

221

Q8N7A1
TAWSLMDGFEWHRGY

KL

456

Q9UEF7
QSTGRTYWVHWHMLE

CUL9

421

Q8IWT3
QAWTSHLWKMFYDAR

EMC1

496

Q8N766
WYMEYSHRMWGRLVG

COX15

146

Q7KZN9
WWGARHDSGCMYRLL

FBXO27

191

Q8NI29
WAAHSIWGQSLREYM

METTL17

201

Q9H7H0
RMDYLHFEDDSRGWW

RNF180

546

Q86T96
WMAENLAPDHWERYT

MR1

71

Q95460
GLWRAMREWQHTSNF

NUTM2G

256

Q5VZR2
SWGDQTFRLHWSNML

FER1L6

586

Q2WGJ9
LRIAWNLSWYHGSDN

RTTN

1021

Q86VV8
LWEASGHWQHYSENM

TARS3

461

A2RTX5
RLWMTSGHWQHYSEN

TARS1

381

P26639
HAERQLLYRSWFMWH

SFI1

546

A8K8P3
LLYRSWFMWHQQAAA

SFI1

551

A8K8P3
DWWCLGAVLYEMLHG

SGK2

216

Q9HBY8
HNRAVDWWSLGALMY

RPS6KB2

246

Q9UBS0
HWMEWFSYRGGRLDQ

LRTM2

211

Q8N967
QSAWFYHRWLLGRAD

RABGGTA

226

Q92696
LWFEVQGSALMLHWR

EPHB6

376

O15197
MDWLNDTLWVYHPST

SETD1B

1711

Q9UPS6
HWLGDNYARWDNMDK

SI

1496

P14410
RLFWWYHSMANEKNL

SGMS2

286

Q8NHU3
MLWWTANDTHIESAY

IL1R2

271

P27930
LYWRIWHMDLIQSAV

SSR3

46

Q9UNL2
WMTEYLNRHLHTWIQ

BCL2

176

P10415
DLSEYNMLWHAGKVW

RIOK3

406

O14730
RRVQWGAAWYAMHSR

SLC7A14

11

Q8TBB6
ASGQVRSHYVDWRMW

MRPS14

21

O60783
MAAAAARWNHVWVGT

WDR74

1

Q6RFH5
WLAMADFRKTGDYLW

WNT2

221

P09544
IPAWWVSMDAYLNHA

XKRY

106

O14609
RWDTYLTMSDVQIHW

TM9SF4

266

Q92544
DEHARVMSWWDYGYQ

STT3B

596

Q8TCJ2
SGTMLRVAHLNFWGW

TMEM186

136

Q96B77
LWHMRNNFLFGSRCW

MTERF1

26

Q99551
LFWWEYEHNNRKMSG

GTF3C4

316

Q9UKN8
SWYHDRGWAKISNMT

TNFSF11

186

O14788
HYWEVGMNITGDALW

TRIM17

351

Q9Y577
QWAVEHNGYAWSESM

UBR2

906

Q8IWV8
LQGDAWHLRKMDWCY

USP40

881

Q9NVE5
VAMYFTREEWGHLNW

ZNF789

16

Q5FWF6
AAVGGYLMWRNWQHK

VLDLR

811

P98155
WRYWCMTNGLKDHTD

KIAA1958

431

Q8N8K9