Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	ZC3H12C PUM1 UBAP2L POLDIP3 NUFIP2	1.46e-05	269	25	5	GO:0036464
GeneOntologyCellularComponent	ribonucleoprotein granule	ZC3H12C PUM1 UBAP2L POLDIP3 NUFIP2	2.00e-05	287	25	5	GO:0035770
GeneOntologyCellularComponent	cytoplasmic stress granule	PUM1 UBAP2L NUFIP2	2.01e-04	96	25	3	GO:0010494
MousePheno	failure of eyelid fusion	JUN TCF7L1 NECTIN1	2.39e-06	20	19	3	MP:0009264
MousePheno	abnormal eyelid fusion	JUN TCF7L1 NECTIN1	7.61e-06	29	19	3	MP:0009263
MousePheno	abnormal eyelid development	JUN TCF7L1 NECTIN1	9.34e-06	31	19	3	MP:0009651
MousePheno	abnormal enamel rod pattern	AMELX NECTIN1	4.88e-05	8	19	2	MP:0002649
MousePheno	eyelids open at birth	JUN TCF7L1 NECTIN1	6.27e-05	58	19	3	MP:0001302
MousePheno	abnormal tooth wear	AMELX NECTIN1	7.83e-05	10	19	2	MP:0030458
MousePheno	brittle teeth	AMELX NECTIN1	1.15e-04	12	19	2	MP:0000126
MousePheno	abnormal enamel mineralization	AMELX NECTIN1	1.35e-04	13	19	2	MP:0030450
MousePheno	short incisors	AMELX NECTIN1	1.58e-04	14	19	2	MP:0004830
MousePheno	abnormal incisor color	AMELX NECTIN1	2.08e-04	16	19	2	MP:0010096
MousePheno	small incisors	AMELX NECTIN1	3.98e-04	22	19	2	MP:0030079
MousePheno	abnormal molar crown morphology	AMELX NECTIN1	3.98e-04	22	19	2	MP:0003932
MousePheno	abnormal ameloblast morphology	AMELX NECTIN1	3.98e-04	22	19	2	MP:0002650
MousePheno	abnormal lower incisor morphology	AMELX NECTIN1	5.15e-04	25	19	2	MP:0030136
MousePheno	abnormal tooth mineralization	AMELX NECTIN1	5.58e-04	26	19	2	MP:0002817
MousePheno	microdontia	AMELX NECTIN1	5.58e-04	26	19	2	MP:0030088
MousePheno	abnormal enamel development	AMELX NECTIN1	6.02e-04	27	19	2	MP:0030544
MousePheno	abnormal tooth color	AMELX NECTIN1	1.32e-03	40	19	2	MP:0013129
Domain	HMG_box	SOX6 TOX TCF7L1	4.19e-05	53	24	3	PF00505
Domain	HMG	SOX6 TOX TCF7L1	4.43e-05	54	24	3	SM00398
Domain	HMG_BOX_2	SOX6 TOX TCF7L1	4.43e-05	54	24	3	PS50118
Domain	-	SOX6 TOX TCF7L1	4.68e-05	55	24	3	1.10.30.10
Domain	HMG_box_dom	SOX6 TOX TCF7L1	7.73e-05	65	24	3	IPR009071
Pubmed	Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.	MED15 PUM1	1.49e-06	3	25	2	22916034
Pubmed	Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.	AMELX TCF7L1	1.78e-05	9	25	2	17335794
Pubmed	The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice.	AMELX NECTIN1	1.78e-05	9	25	2	18703497
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX6 JUN TOX BRDT FOXJ3 TCF7L1	1.87e-05	808	25	6	20412781
Pubmed	SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system.	SOX6 JUN	3.26e-05	12	25	2	34234180
Pubmed	Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.	SOX6 TCF7L1	4.49e-05	14	25	2	33195246
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	PUM1 UBAP2L NUFIP2	4.63e-05	97	25	3	37151849
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CBLL1 JUN PUM1 UBAP2L POLDIP3 NUFIP2	4.75e-05	954	25	6	36373674
Pubmed	Human transcription factor protein interaction networks.	SOX6 MED15 JUN SALL2 PUM1 UBAP2L POLDIP3	4.88e-05	1429	25	7	35140242
Pubmed	Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes.	JUN SCHIP1	5.92e-05	16	25	2	15867431
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	PUM1 UBAP2L NUFIP2	6.20e-05	107	25	3	30995489
Pubmed	Notch Signaling Pathway in Tooth Shape Variations throughout Evolution.	AMELX TCF7L1	7.54e-05	18	25	2	36899896
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SCHIP1 ZC3H12C PLEKHA6 PUM1 UBAP2L MCM3AP	7.58e-05	1038	25	6	26673895
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PUM1 UBAP2L POLDIP3 MCM3AP NUFIP2	8.94e-05	653	25	5	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	PUM1 UBAP2L POLDIP3 MCM3AP NUFIP2	9.07e-05	655	25	5	35819319
Pubmed	Molecular evolution of Sry and Sox gene.	SOX6 TCF7L1	9.35e-05	20	25	2	11404013
Pubmed	Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.	JUN TCF7L1	9.35e-05	20	25	2	22573616
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	FOXJ3 UBAP2L MCM3AP	1.11e-04	130	25	3	12421765
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	JUN SALL2 TOX FOXJ3 TCF7L1	1.31e-04	709	25	5	22988430
Pubmed	Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.	JUN SALL2 TCF7L1	1.38e-04	140	25	3	26930384
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	HRG SALL2 BRDT TCF7L1	1.73e-04	396	25	4	26687479
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	MED15 JUN FOXJ3	1.75e-04	152	25	3	38360978
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	PUM1 UBAP2L NUFIP2	1.89e-04	156	25	3	26170170
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PUM1 UBAP2L MCM3AP NUFIP2	1.92e-04	407	25	4	12693553
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	JUN PUM1 UBAP2L POLDIP3 NUFIP2	2.40e-04	807	25	5	22681889
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	MED15 SALL2 UBAP2L NUFIP2	2.68e-04	444	25	4	34795231
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	FOXJ3 POLDIP3 MCM3AP	3.76e-04	197	25	3	20811636
Pubmed	Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.	SOX6 TOX	3.80e-04	40	25	2	27657450
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX6 JUN SALL2 FOXJ3 TCF7L1	4.13e-04	908	25	5	19274049
Pubmed	Genetic evidence that SOST inhibits WNT signaling in the limb.	JUN TCF7L1	4.82e-04	45	25	2	20359476
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	UBAP2L NUFIP2	6.94e-04	54	25	2	25631074
Interaction	LSM14A interactions	SOX6 PUM1 UBAP2L POLDIP3 NUFIP2	1.20e-05	260	24	5	int:LSM14A
Disease	electrocardiography	HRG PLEKHA6 GOLM2 NUFIP2	9.65e-04	530	25	4	EFO_0004327
Disease	cigarettes per day measurement	SOX6 FNTA NUFIP2	5.86e-03	438	25	3	EFO_0006525
Disease	Schizophrenia	MED15 JUN PLEKHA6 NUFIP2	6.10e-03	883	25	4	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
QHSMTPIQHHQPNLP	AMELX	106	Q99217
PSHVMPPNHHQLAFN	BRDT	726	Q58F21
PLPHHKHPLKPDNQP	HRG	481	P04196
EHPPMLVNPPHIQNI	MAP10	361	Q9P2G4
QPPHHLPQQMPVQHP	JUN	206	P05412
HPSANNFPIPLLHMH	MCM3AP	1816	O60318
QQMHHTQHHQPPPQP	MED15	291	Q96RN5
HLKHHPQEPANPNMP	PUM1	21	Q14671
PVVSHPHHIMPPQQH	CBLL1	326	Q75N03
SHPQMHTQPSPHPPH	FOXJ3	371	Q9UPW0
KYPHVQMNPHPVPEH	SALL2	426	Q9Y467
VPQQKAMAPLHPHPA	POLDIP3	151	Q9BY77
PNMPPDSHINHNGNP	GOLM2	296	Q6P4E1
TAMPPPVPNGNLHQH	SCHIP1	141	P0DPB3
PHPPPPQQQHKEEMA	FNTA	26	P49354
SQAPPQPHHMAQPQH	SPATA31E1	491	Q6ZUB1
LPLHPIMHNKPHSEE	SOX6	41	P35712
NLHIMHPHPPQEPSA	CFAP20DC	216	Q6ZVT6
PSKHHQQPPHNSLPK	PLEKHA6	186	Q9Y2H5
PFMHILTPHQQPHSQ	UBAP2L	1031	Q14157
MEEKPGQPQPQHHHS	NUFIP2	1	Q7Z417
SNKVPVVQHPHHMHP	TCF7L1	176	Q9HCS4
KCQHMHPHSRLNPQP	ZC3H12C	661	Q9C0D7
LCHPMNHNGLLPFHP	TOX	96	O94900
SKAGIPQHHPPMAQN	NECTIN1	401	Q15223