Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

SORT1 IL12RB1 NPY5R IGF2R EFEMP1 RAMP3 CD300LF OR2L5 INSRR PKD1 LRP6 CCR3 TAS2R31 PKD1L3 KIT GNRHR CHRNE SORL1

2.85e-0513539018GO:0004888
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

IGF2R EFEMP1 INSRR KIT

2.12e-0465904GO:0004714
GeneOntologyMolecularFunctionpeptide binding

TRHDE NPY5R RAMP3 KDELR1 GSAP GNRHR SORL1

5.87e-04318907GO:0042277
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

IGF2R EFEMP1 INSRR KIT

5.91e-0485904GO:0019199
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1D SLC24A4 PKD1 PKD1L3 ATP2B3

6.07e-04151905GO:0015085
GeneOntologyMolecularFunctiontransporter activity

CACNA1D SLC24A4 SLC6A16 PSG5 SLC22A10 SLC6A19 PKD1 SLC19A2 LRP6 KCNK12 NDUFA8 PKD1L3 ATP2B3 CHRNE CFHR4

6.10e-0412899015GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1D SLC24A4 SLC6A16 PSG5 SLC22A10 SLC6A19 PKD1 SLC19A2 LRP6 KCNK12 NDUFA8 PKD1L3 ATP2B3 CHRNE

7.83e-0411809014GO:0022857
GeneOntologyMolecularFunctionretromer complex binding

SORT1 IGF2R

8.83e-0410902GO:1905394
GeneOntologyCellularComponentcell surface

SORT1 CACNA1D IL12RB1 IGF2R RAMP3 PSG5 MRC2 LPA PKD1 PKHD1 LRP6 CP ASTN1 CCR3 PKD1L3 KIT PTGFRN HYAL2 SORL1 CFHR4

4.85e-0811119120GO:0009986
GeneOntologyCellularComponentcilium

NPHP3 SLC24A4 IFT88 PSG5 BBS7 DNAH17 PKD1 PKHD1 TAS2R31 CFAP61 CATSPERG PTGS1 CFAP65

1.34e-048989113GO:0005929
GeneOntologyCellularComponentplasma membrane signaling receptor complex

IL12RB1 RAMP3 PSG5 INSRR IKBKB PLP1 SHISA6 CHRNE

1.45e-04350918GO:0098802
GeneOntologyCellularComponentreceptor complex

IL12RB1 RAMP3 PSG5 INSRR IKBKB PKD1L3 KIT PLP1 SHISA6 CHRNE

2.17e-045819110GO:0043235
GeneOntologyCellularComponentmembrane protein complex

CACNA1D IL12RB1 IGF2R RAMP3 PSG5 INSRR PKD1 LRP6 KCNK12 NDUFA8 IKBKB PKD1L3 CATSPERG PLP1 PIK3R5 SHISA6 CHRNE

2.26e-0414989117GO:0098796
GeneOntologyCellularComponentexternal side of plasma membrane

IL12RB1 PSG5 LPA PKHD1 ASTN1 CCR3 KIT HYAL2 CFHR4

4.31e-04519919GO:0009897
GeneOntologyCellularComponent9+0 non-motile cilium

SLC24A4 IFT88 BBS7 PKHD1 PTGS1

5.52e-04153915GO:0097731
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1D IL12RB1 RAMP3 PSG5 INSRR LRP6 IKBKB CATSPERG PLP1 SHISA6 CHRNE

5.99e-047859111GO:0098797
GeneOntologyCellularComponentmotile cilium

IFT88 DNAH17 PKD1 TAS2R31 CFAP61 CATSPERG CFAP65

9.16e-04355917GO:0031514
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1D PKD1 KCNK12 PKD1L3 CATSPERG SHISA6 CHRNE

1.32e-03378917GO:0034702
GeneOntologyCellularComponentGolgi-associated vesicle

SORT1 IGF2R PKD1 KDELR1

1.56e-03114914GO:0005798
GeneOntologyCellularComponentnuclear envelope lumen

IGF2R SORL1

1.65e-0314912GO:0005641
GeneOntologyCellularComponentnon-motile cilium

SLC24A4 IFT88 BBS7 PKHD1 PTGS1

1.67e-03196915GO:0097730
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1D PKD1 KCNK12 NDUFA8 PKD1L3 CATSPERG SHISA6 CHRNE

2.01e-03523918GO:1902495
MousePhenopancreas cyst

IFT88 PKD1 PKHD1 MEN1

2.32e-0711744MP:0003336
MousePhenoabnormal kidney epithelial cell primary cilium morphology

NPHP3 IFT88 PKD1 PKHD1

5.94e-0623744MP:0011065
MousePhenoabnormal kidney epithelium morphology

NPHP3 IFT88 PKD1 PKHD1 DCN

1.71e-0561745MP:0004967
MousePhenoabnormal pancreatic duct morphology

IFT88 PKD1 PKHD1

3.03e-0512743MP:0009143
MousePhenoabnormal renal tubule epithelial cell primary cilium morphology

NPHP3 IFT88 PKHD1

7.59e-0516743MP:0011066
MousePhenoabnormal renal tubule epithelium morphology

NPHP3 IFT88 PKHD1 DCN

1.18e-0448744MP:0009640
MousePhenoabnormal vagina morphology

IGF2R LPA KIT GNRHR

1.50e-0451744MP:0001139
MousePhenoreduced female fertility

TYRP1 RELN IGF2R LPA KMT2A DCN KIT GNRHR

1.65e-04296748MP:0001923
MousePhenorenal interstitial fibrosis

NPHP3 PKD1 PKHD1 DCN

1.87e-0454744MP:0003215
MousePhenodilated renal tubule

NPHP3 IFT88 PKD1 PKHD1 DCN

1.93e-04101745MP:0002705
DomainEGF_3

RELN EFEMP1 ZAN LRP6 ASTN1 PTGS1 MEGF11 HYAL2 SORL1

1.48e-06235879PS50026
DomainEGF

RELN EFEMP1 ZAN LRP6 ASTN1 PTGS1 MEGF11 HYAL2 SORL1

1.48e-06235879SM00181
DomainEGF-like_dom

RELN EFEMP1 ZAN LRP6 ASTN1 PTGS1 MEGF11 HYAL2 SORL1

2.39e-06249879IPR000742
DomainEGF-like_CS

RELN EFEMP1 ZAN LRP6 ASTN1 PTGS1 MEGF11 HYAL2 SORL1

3.51e-06261879IPR013032
DomainEGF_2

RELN EFEMP1 ZAN LRP6 ASTN1 PTGS1 MEGF11 HYAL2 SORL1

3.98e-06265879PS01186
DomainEGF_1

RELN EFEMP1 ZAN LRP6 ASTN1 PTGS1 MEGF11 HYAL2

2.49e-05255878PS00022
DomainPC1

PKD1 PKD1L3

1.28e-044872IPR000434
DomainVPS10

SORT1 SORL1

2.13e-045872SM00602
DomainSortilin_C

SORT1 SORL1

2.13e-045872PF15901
DomainSortilin-Vps10

SORT1 SORL1

2.13e-045872PF15902
DomainVPS10

SORT1 SORL1

2.13e-045872IPR006581
DomainSortilin_N

SORT1 SORL1

2.13e-045872IPR031778
DomainSortilin_C

SORT1 SORL1

2.13e-045872IPR031777
DomainVal/Leu/Ile-tRNA-synth_edit

LARS1 VARS1

3.18e-046872IPR009008
DomainAnticodon_1

LARS1 VARS1

3.18e-046872PF08264
DomainHELP

EML5 EML6

3.18e-046872PF03451
DomainHELP

EML5 EML6

3.18e-046872IPR005108
DomainM/V/L/I-tRNA-synth_anticd-bd

LARS1 VARS1

3.18e-046872IPR013155
Domain-

LARS1 VARS1

3.18e-0468723.90.740.10
DomainHaem_d1

EML6 KMT2A

3.18e-046872IPR011048
DomainKringle-like

IGF2R MRC2 LPA

4.39e-0432873IPR013806
Domainaa-tRNA-synth_Ia

LARS1 VARS1

4.44e-047872IPR002300
DomaintRNA-synt_1

LARS1 VARS1

4.44e-047872PF00133
DomainMan6P_isomerase_rcpt-bd_dom

IGF2R ELAPOR1

5.90e-048872IPR009011
DomainSialidases

RELN SORL1

7.56e-049872IPR011040
DomainBTB-kelch_protein

KLHL9 KLHL7 KLHL14

1.05e-0343873IPR017096
DomainPKD_channel

PKD1 PKD1L3

1.15e-0311872PF08016
Domain-

LARS1 VARS1

1.15e-03118721.10.730.10
DomainPKD1_2_channel

PKD1 PKD1L3

1.15e-0311872IPR013122
DomainLDLRA_1

PKD1 LRP6 SORL1

1.45e-0348873PS01209
DomainLDLRA_2

PKD1 LRP6 SORL1

1.54e-0349873PS50068
Domain-

IGF2R MRC2

1.62e-03138722.10.10.10
DomainFN_type2_col-bd

IGF2R MRC2

1.88e-0314872IPR000562
DomainFN2_2

IGF2R MRC2

1.88e-0314872PS51092
DomainLdl_recept_b

LRP6 SORL1

1.88e-0314872PF00058
DomainLDLRB

LRP6 SORL1

1.88e-0314872PS51120
Domainfn2

IGF2R MRC2

1.88e-0314872PF00040
DomainFN2_1

IGF2R MRC2

1.88e-0314872PS00023
DomainFN2

IGF2R MRC2

1.88e-0314872SM00059
DomainCarbonic_anhydrase_a-class

CA14 CA3

2.17e-0315872IPR023561
DomainALPHA_CA_1

CA14 CA3

2.17e-0315872PS00162
DomaintRNAsynth_Ia_anticodon-bd

LARS1 VARS1

2.17e-0315872IPR009080
DomainLY

LRP6 SORL1

2.17e-0315872SM00135
DomainLDLR_classB_rpt

LRP6 SORL1

2.17e-0315872IPR000033
DomainKelch

KLHL9 KLHL7 KLHL14

2.50e-0358873SM00612
DomainBACK

KLHL9 KLHL7 KLHL14

2.76e-0360873SM00875
DomainALPHA_CA_2

CA14 CA3

2.79e-0317872PS51144
DomainCarb_anhydrase

CA14 CA3

2.79e-0317872PF00194
DomainCarb_anhydrase

CA14 CA3

2.79e-0317872SM01057
Domain-

CA14 CA3

2.79e-03178723.10.200.10
DomainCarbonic_anhydrase_a

CA14 CA3

2.79e-0317872IPR001148
DomainBACK

KLHL9 KLHL7 KLHL14

2.89e-0361873PF07707
DomainBACK

KLHL9 KLHL7 KLHL14

2.89e-0361873IPR011705
Domainaa-tRNA-synth_I_CS

LARS1 VARS1

3.13e-0318872IPR001412
DomainLH2

PKD1 PKD1L3

3.13e-0318872SM00308
DomainSNF

SLC6A16 SLC6A19

3.48e-0319872PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A16 SLC6A19

3.48e-0319872PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A16 SLC6A19

3.48e-0319872PS50267
DomainNa/ntran_symport

SLC6A16 SLC6A19

3.48e-0319872IPR000175
DomainAA_TRNA_LIGASE_I

LARS1 VARS1

3.48e-0319872PS00178
Domain-

IL12RB1 CD300LF PSG5 INSRR PKHD1 ASTN1 KIT PTGFRN SORL1

3.70e-036638792.60.40.10
DomainApc4_WD40_dom

EML5 EML6

3.86e-0320872IPR024977
DomainANAPC4_WD40

EML5 EML6

3.86e-0320872PF12894
DomainPLAT

PKD1 PKD1L3

4.25e-0321872PS50095
Domain-

PKD1 PKD1L3

4.25e-03218722.60.60.20
DomainPLAT

PKD1 PKD1L3

4.25e-0321872PF01477
DomainPLAT/LH2_dom

PKD1 PKD1L3

4.25e-0321872IPR001024
DomainKelch_1

KLHL9 KLHL7 KLHL14

4.27e-0370873PF01344
DomainKelch_1

KLHL9 KLHL7 KLHL14

4.27e-0370873IPR006652
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

CACNA1D IL12RB1 TYRP1 IGF2R DNAH17 CFAP61 CSMD2 TRAM2

5.03e-0726591819240061
Pubmed

Murine models of polycystic kidney disease: molecular and therapeutic insights.

NPHP3 IFT88 PKD1

1.44e-06991314600027
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

KLHL9 SSH1 ELAPOR1 LARS1 KLHL14 PTGFRN

3.22e-0615391610718198
Pubmed

Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.

KIT PTGS1

6.77e-06291223966321
Pubmed

Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1.

IFT88 PKD1

6.77e-06291218285569
Pubmed

The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.

CD300LF KIT

6.77e-06291223123064
Pubmed

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

KMT2A MEN1

6.77e-06291220961854
Pubmed

Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2.

RAMP3 LOXL2

6.77e-06291220802105
Pubmed

Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation.

CD300LF KIT

6.77e-06291224035150
Pubmed

Interaction of MLL amino terminal sequences with menin is required for transformation.

KMT2A MEN1

6.77e-06291217671196
Pubmed

An MLL-dependent network sustains hematopoiesis.

KMT2A MEN1

6.77e-06291223744037
Pubmed

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein.

PKD1 PKHD1

6.77e-06291211919560
Pubmed

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

KMT2A MEN1

6.77e-06291222936661
Pubmed

Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney disease.

IFT88 PKD1

6.77e-06291225999403
Pubmed

Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.

KMT2A MEN1

6.77e-06291227801610
Pubmed

Pathogenicity analysis of novel variations in Chinese Han patients with polycystic kidney disease.

PKD1 PKHD1

6.77e-06291228578020
Pubmed

Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1-KMT2A Interaction.

KMT2A MEN1

6.77e-06291238003662
Pubmed

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

SORT1 LPA

6.77e-06291229973585
Pubmed

Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.

KMT2A MEN1

6.77e-06291227888797
Pubmed

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

KMT2A MEN1

6.77e-06291215640349
Pubmed

Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.

CD300LF KIT

6.77e-06291228073916
Pubmed

Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

NPHP3 BBS7 PKD1 PKHD1

1.08e-055291420301743
Pubmed

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

IFT88 PKD1 PKHD1

1.15e-051791316472605
Pubmed

Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

SORT1 LPA RNF213

1.63e-051991323118302
Pubmed

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.

IFT88 PKD1 PKHD1

1.91e-052091317251353
Pubmed

Characterization of PKD protein-positive exosome-like vesicles.

PKD1 PKHD1

2.03e-05391219158352
Pubmed

Menin critically links MLL proteins with LEDGF on cancer-associated target genes.

KMT2A MEN1

2.03e-05391218598942
Pubmed

Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.

KMT2A KIT

2.03e-05391216029447
Pubmed

SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.

KMT2A MEN1

2.03e-05391226990989
Pubmed

Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.

SORT1 IGF2R

2.03e-05391211859376
Pubmed

The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.

KMT2A MEN1

2.03e-05391234582559
Pubmed

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis.

KMT2A KIT

2.03e-05391232549410
Pubmed

Vinblastine Resistance Is Associated with Nephronophthisis 3-Mediated Primary Cilia via Intraflagellar Transport Protein 88 and Apoptosis-Antagonizing Transcription Factor.

NPHP3 IFT88

2.03e-05391239408701
Pubmed

Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.

CD300LF KIT

2.03e-05391228655892
Pubmed

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

IKBKB KIT

2.03e-05391226353931
Pubmed

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.

IFT88 PKD1

2.03e-05391212514735
Pubmed

Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.

CACNA1D ATP2B3

2.03e-05391226285814
Pubmed

Palmitoylation controls recycling in lysosomal sorting and trafficking.

SORT1 IGF2R

2.03e-05391218817523
Pubmed

The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.

KMT2A MEN1

2.03e-05391225305204
Pubmed

Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs).

PKD1 PKHD1

2.03e-05391232001768
Pubmed

Menin is necessary for long term maintenance of meningioma-1 driven leukemia.

KMT2A MEN1

2.03e-05391233542482
Pubmed

Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis.

SORT1 SORL1

2.03e-05391232712736
Pubmed

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

KMT2A MEN1

2.03e-05391216604156
Pubmed

Expression of polycystins and fibrocystin on primary cilia of lung cells.

PKD1 PKHD1

2.03e-05391225367197
Pubmed

Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families.

SORT1 SORL1

2.03e-05391218603531
Pubmed

Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.

KMT2A MEN1

2.03e-05391223908472
Pubmed

Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.

SORT1 SORL1

2.03e-05391222297619
Pubmed

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

IFT88 PKD1

2.03e-05391216567633
Pubmed

Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis.

PKD1 PKHD1

2.03e-05391237845212
Pubmed

Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.

KIT PTGS1

2.03e-05391221858200
Pubmed

GGA autoinhibition revisited.

SORT1 SORL1

2.03e-05391220015111
Pubmed

Association between brown eye colour in rs12913832:GG individuals and SNPs in TYR, TYRP1, and SLC24A4.

TYRP1 SLC24A4

2.03e-05391232915910
Pubmed

CD antigens 1993.

LRP6 KIT

2.03e-0539127909665
Pubmed

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.

KMT2A MEN1

2.03e-05391216239140
Pubmed

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

KMT2A MEN1

2.03e-05391231855575
Pubmed

Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein.

SORT1 SORL1

2.03e-05391223283322
Pubmed

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

KMT2A MEN1

2.03e-05391230315824
Pubmed

In silico QTL mapping of basal liver iron levels in inbred mouse strains.

IGF2R LPA LMTK2

2.23e-052191321062905
Pubmed

Primary Cilia Deficiency Induces Intracranial Aneurysm.

IFT88 PKD1

4.05e-05491228800037
Pubmed

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.

KMT2A KIT

4.05e-05491227396339
Pubmed

MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

KMT2A MEN1

4.05e-05491226927674
Pubmed

The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.

SORT1 SORL1

4.05e-05491211821067
Pubmed

A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.

NPHP3 PKD1

4.05e-05491220554900
Pubmed

Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma.

CACNA1D ATP2B3

4.05e-05491226351028
Pubmed

Haploinsufficient and predominant expression of multiple endocrine neoplasia type 1 (MEN1)-related genes, MLL, p27Kip1 and p18Ink4C in endocrine organs.

KMT2A MEN1

4.05e-05491222037578
Pubmed

Cilia and polycystic kidney disease.

PKD1 PKHD1

4.05e-05491232475690
Pubmed

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.

SORT1 SORL1

4.05e-05491218480253
Pubmed

Loss of oriented cell division does not initiate cyst formation.

PKD1 PKHD1

4.05e-05491219959710
Pubmed

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

KMT2A MEN1

4.05e-05491220064463
Pubmed

Cystic kidney diseases.

NPHP3 PKD1

4.05e-0549129263671
Pubmed

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development.

KMT2A MEN1

4.05e-05491220484083
Pubmed

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

KMT2A MEN1

4.05e-05491219703992
Pubmed

Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice.

RELN PLP1

4.05e-0549126960362
Pubmed

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.

IFT88 PKD1

4.05e-05491224235270
Pubmed

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia.

IFT88 PKD1

4.05e-05491212239239
Pubmed

Linkage analysis of two murine polycystic kidney disease genes, pcy and cpk.

TYRP1 NPHP3

4.05e-0549121748176
Pubmed

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.

SORT1 SORL1

4.05e-05491223283348
Pubmed

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.

NPHP3 PKD1

4.05e-05491220562878
Pubmed

miR-24 regulates menin in the endocrine pancreas.

KMT2A MEN1

4.05e-05491224824656
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PIKFYVE NPHP3 SSH1 DNAH17 ELAPOR1 RNF213 KLHL14 PTGFRN

4.68e-0549391815368895
Pubmed

A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.

PKD1 PKHD1

6.74e-05591221685914
Pubmed

Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.

KMT2A MEN1

6.74e-05591221670200
Pubmed

Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome.

TYRP1 PLP1

6.74e-0559129321476
Pubmed

Animal models of polycystic kidney disease.

NPHP3 PKD1

6.74e-0559127661851
Pubmed

Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.

IFT88 PKD1

6.74e-05591221041232
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2A MEN1

6.74e-05591228609655
Pubmed

Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.

IGF2R LPA

6.74e-05591221273553
Pubmed

Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.

SLC24A4 SORL1

6.74e-05591225365775
Pubmed

Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium.

IFT88 PKD1

6.74e-05591226245976
Pubmed

TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor.

TYRP1 KIT

6.74e-0559121280558
Pubmed

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.

IFT88 PKD1

6.74e-05591233046531
Pubmed

The ferroxidase ceruloplasmin influences Reelin processing, cofilin phosphorylation and neuronal organization in the developing brain.

RELN CP

6.74e-05591230077770
Pubmed

The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters.

IGF2R LPA

6.74e-0559128854860
Pubmed

Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.

CACNA1D KIT

6.74e-05591212060068
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SORT1 IGF2R EFEMP1 GTF3C1 MRC2 LOXL2 KDELR1 LRP6 RNF213 PTGFRN PTGS1 SORL1

6.96e-051201911235696571
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

RELN EFEMP1 LOXL2 LPA DCN

9.98e-0517591528071719
Pubmed

Activation and functional characterization of the mosaic receptor SorLA/LR11.

SORT1 SORL1

1.01e-04691211294867
Pubmed

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

KMT2A MEN1

1.01e-04691222327296
Pubmed

Loss of polycystin-1 inhibits Bicc1 expression during mouse development.

PKD1 PKHD1

1.01e-04691224594709
Pubmed

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.

KMT2A MEN1

1.01e-04691220093773
Cytoband3p21.3

ENTPD3 CCR3 HYAL2

2.33e-04599233p21.3
Cytoband6q26

IGF2R LPA

5.95e-04189226q26
CytobandEnsembl 112 genes in cytogenetic band chr2p16

EFEMP1 EML6 KCNK12

1.89e-03121923chr2p16
GeneFamilyReceptor Tyrosine Kinases|CD molecules

INSRR LMTK2 KIT

3.63e-0440633321
GeneFamilyKelch like|BTB domain containing

KLHL9 KLHL7 KLHL14

4.20e-0442633617
GeneFamilyCarbonic anhydrases

CA14 CA3

1.76e-0318632460
GeneFamilyAminoacyl tRNA synthetases, Class I

LARS1 VARS1

1.97e-0319632131
GeneFamilyFibronectin type III domain containing

IL12RB1 INSRR ASTN1 SORL1

2.35e-03160634555
GeneFamilyADAM metallopeptidase domain containing|CD molecules

IL12RB1 IGF2R MRC2 CCR3 KIT PTGFRN

2.46e-03394636471
CoexpressionCHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_UP

LPA LRP6 CP GSAP SORL1

1.19e-0586905M19610
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

GTF3C1 SSH1 MRC2 SLC19A2 ELOVL1 LMTK2 TRAM2 PTGS1 VARS1 HYAL2 MEN1

2.17e-056819011M5314
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

GTF3C1 SSH1 MRC2 SLC19A2 ELOVL1 LMTK2 TRAM2 PTGS1 VARS1 HYAL2 MEN1

2.91e-057039011MM1055
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SORT1 SLC24A4 LMTK2 KCNK12 SORL1 CFAP65

1.06e-06161926ba7ce599b173cf81c8323e7c96dc3d57379f1ed6
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE CD300LF LPA ELAPOR1 KIT PTGS1

1.35e-061689268072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE TYRP1 SLC22A10 PTCHD4 PTGFRN PTGS1

1.72e-06175926030f93af5a96848b9118e2a8116e19ddae438d92
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE TYRP1 SLC22A10 PTCHD4 PTGFRN PTGS1

1.78e-06176926cd4b9211652596c42e7af318bcd464681daebb10
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE CD300LF ELAPOR1 CFAP61 KIT PTGS1

1.90e-06178926f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE CD300LF CFAP61 KIT PIK3R5 PTGS1

1.96e-06179926906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE TYRP1 SLC22A10 PTCHD4 PTGFRN PTGS1

2.02e-061809262ae39e26a8e7d5d4d3e1e71609a8ec36fd9855aa
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE CD300LF LPA ELAPOR1 KIT PTGS1

2.37e-06185926686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D RELN EML5 ENTPD3 INSRR ASTN1

2.60e-06188926a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

2.68e-06189926979b7fa947538aa7ca4a219263da2575869a2caa
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE CD300LF LPA ELAPOR1 KIT PTGS1

2.85e-0619192654f07e4de61735051498846afb44b1798bed8144
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

2.94e-06192926f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

2.94e-0619292663d1b3efe93e5ff939278ebe40bacb38218ea09b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

2.94e-06192926bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

2.94e-06192926690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ENTPD3 DCN PTCHD4 KIT SHISA6

3.03e-061939269f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCellfacs-Kidney-nan-18m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 CP DCN PTGFRN CHRNE

3.12e-06194926bbc625b4cc53bb7d6254fde287258e51f9171572
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

3.12e-0619492652aebb0b563e2c2058e7f0554ae870e47692b163
ToppCellfacs-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 CP DCN PTGFRN CHRNE

3.12e-06194926fcd5e9238d299c41f0bf9693b56cd8c900d2112b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 ENTPD3 PTCHD4 KIT CA3

3.12e-06194926bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCellfacs-Kidney-nan-18m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 CP DCN PTGFRN CHRNE

3.12e-061949266afc21c5fec30ab8e373e3e46ab7866204c805b6
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RELN RAMP3 ARHGAP31 KLHL14 PKD1L3 HYAL2

3.31e-0619692609a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RELN RAMP3 ARHGAP31 KLHL14 PKD1L3 HYAL2

3.31e-06196926e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EFEMP1 RAMP3 ASTN1 DCN PLP1 SHISA6

3.71e-06200926747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EFEMP1 RAMP3 ASTN1 DCN PLP1 SHISA6

3.71e-06200926de1d193f773f4e2927baa6fc38d29754b015c6e6
ToppCellLPS-IL1RA-Epithelial_alveolar-Mes-Like-AT1_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TYRP1 RAMP3 PKHD1 PTGS1 CFAP65

4.48e-06117925f3c77b234e461566aac81ede0ef84008c9a9f51e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRHDE RELN KLHL14 PTGS1 SHISA6

4.87e-06119925e868453c02dcf0e07821886b81ca739887d43c67
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRHDE RELN KLHL14 PTGS1 SHISA6

5.28e-06121925056d0f0f7a4d1b2d38b83647bbe4468b7c959ce6
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRHDE RELN KLHL14 PTGS1 SHISA6

7.22e-06129925f83187c0bb06528127b8d2d56674ab1946846951
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SORT1 SLC24A4 CFAP61 SORL1 CFAP65

1.19e-051439255fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCellLPS-antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC6A16 CCR3 KIT PTGS1 SHISA6

1.23e-05144925013223bb2f31eb5bebdbd0908b797d28b96c6f7b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRHDE RELN EFEMP1 KLHL14 PTGS1

1.70e-05154925a2adaa4a6cd8708cd579b8efbeb4ff2131c5482e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRHDE RELN EFEMP1 KLHL14 SHISA6

1.76e-051559255c7b68b59244525e3714806c205a57a2daebf423
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD300LF ELAPOR1 PKHD1 KIT PTGS1

1.81e-0515692558b9520fce6e259b36c3d59e82b712f5e7729e3e
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRHDE RELN KLHL14 PTGS1 SHISA6

2.11e-05161925dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCelllung-Type_I_Pneumocytes|lung / shred on tissue and cell subclass

ELAPOR1 LRP6 CP KIT

2.53e-05829246023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ZAN ARHGAP31 CA14 PTGS1

2.59e-051689253bddf411a60137a8883fc9e77586e4719b0d6067
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ZAN ARHGAP31 CA14 PTGS1

2.59e-05168925b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE CD300LF PSG5 KIT PTGS1

2.66e-0516992505e12524d68d409fed386ffad233305683b4575b
ToppCell343B-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLC6A16 ARHGAP31 LOXL2 ASTN1 PLP1

2.90e-05172925eb199c279fe8a2551121db37e9556893197d33ff
ToppCell3'_v3-GI_small-bowel-Lymphocytic_NK-NK_CD16|GI_small-bowel / Manually curated celltypes from each tissue

IGF2R GTF3C1 SHOC1 GSAP SORL1

2.90e-05172925701de463f85aaad3a4b36a0d5fbc416406620089
ToppCell343B-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SLC6A16 ARHGAP31 LOXL2 ASTN1 PLP1

2.90e-05172925709c6b77a7a52b873eefb6caca28a41291d384af
ToppCell3'_v3-blood-Mast|blood / Manually curated celltypes from each tissue

CACNA1D LMTK2 CCR3 KIT CHRNE

2.90e-05172925e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RELN RAMP3 ARHGAP31 OR2L5 HYAL2

2.90e-05172925c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN LOXL2 APOBEC2 KDELR1 CP

2.98e-0517392503b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCellPND28-Endothelial-Endothelial_lymphatic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN LOXL2 APOBEC2 KDELR1 CP

2.98e-051739252978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN LOXL2 APOBEC2 KDELR1 CP

2.98e-0517392512da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN LOXL2 APOBEC2 KDELR1 CP

2.98e-0517392523d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCellfacs-Lung-Endomucin-24m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ARHGAP31 CA14 GKN1 HYAL2

3.06e-0517492560a426bfe5625999f031776ab34f7bc0d2b331be
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM78A IL12RB1 SSH1 ELAPOR1 CHRNE

3.23e-05176925feafc757e7aa4f17128ff34886beb2fd3461c9ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MRC2 DNAH17 EML6 PKHD1

3.23e-05176925327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN EFEMP1 SLC24A4 ENTPD3 KIT

3.32e-0517792584116796ca4c7007508c0f1a68a1135c7b922278
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE MRC2 DNAH17 EML6 PKHD1

3.32e-05177925da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN NPY5R RAMP3 KLHL14 HYAL2

3.32e-051779256248c0dcad302de61a66163ee84b3b79096150d7
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7-Slc17a8.Syt6-Lancl3_(Cortical_Subplate_pyramidal_cells)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

IL12RB1 GKN1 CATSPERG PIK3R5

3.35e-0588924fcc15c5c30517c63a835b28627c5f779d9bcd17e
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7-Slc17a8.Syt6-Lancl3_(Cortical_Subplate_pyramidal_cells)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

IL12RB1 GKN1 CATSPERG PIK3R5

3.35e-05889247838c65160cf81c02b923fc34f566c0610c8d81b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN EFEMP1 SLC24A4 ENTPD3 KIT

3.41e-051789252a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE TYRP1 SLC22A10 PTCHD4 PTGS1

3.41e-051789255522b179c2e7dd707de01e2df10556349d0382a6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE TYRP1 SLC22A10 PTCHD4 PTGFRN

3.41e-05178925f7f88879a05b2b5fa92cf5317b76f7a3064d1358
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EFEMP1 MRC2 LOXL2 INSRR DCN

3.41e-05178925cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAMP3 MYOZ3 CA14 PTGS1 HYAL2

3.69e-0518192572c28baf4fd417ff4a7068603830d55074960144
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN EFEMP1 SLC24A4 ENTPD3 KIT

3.69e-05181925062f00736eed96e4f4327615d093558dd7d82b20
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAMP3 MYOZ3 CA14 PTGS1 HYAL2

3.69e-051819252ac4d3e8987d5a009d7908d8787e18165826202a
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAMP3 MYOZ3 CA14 PTGS1 HYAL2

3.69e-051819252628c7ac345eaaeecf8e34617e81948925962cb9
ToppCell(00)_Basal-(0)_uninjured|(00)_Basal / shred by cell type and Timepoint

EFEMP1 ELAPOR1 CP DCN PTGS1

3.79e-05182925c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE TYRP1 SLC22A10 PTCHD4 PTGFRN

3.89e-05183925b5d041d0a3506c33de72bf14fa0443f4410fddf1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP31 GKN1 PTCHD4 KIT CA3

3.89e-05183925f8b636391f752e379a5c5575fd898bdf0907a3b8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE KLHL14 DCN PTCHD4 SHISA6

3.89e-051839257961e05c6e9964da159059c6bfb4f7e7e14308c2
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EFEMP1 PSG5 MRC2 DCN PLP1

3.99e-051849254a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EFEMP1 ARHGAP31 PTCHD4 KIT CA3

3.99e-05184925ae0a77e3e520a246b17776bb19503519636b02ee
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN EFEMP1 MRC2 DCN PTGFRN

4.10e-05185925f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN EFEMP1 MRC2 DCN PTGFRN

4.10e-0518592540e958511790e84321da5ccf735f9974c06a0263
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN EFEMP1 MRC2 DCN PTGFRN

4.10e-051859255f2eeba80aff145e85cfd81e2890a155406badb9
ToppCelldroplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.31e-051879253827fa80e558b642f3e0036f5ee1a8b69f437e30
ToppCelldroplet-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.31e-051879251bf696eb03422ea507d3efe58dda1d442a65225d
ToppCelldroplet-Lung-3m-Endothelial-venous_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.31e-05187925ebe4d1216cc0d4c079b413d5a5460cfd3a4af922
ToppCelldroplet-Pancreas|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D EML5 ENTPD3 INSRR ELAPOR1

4.31e-051879255f4df092452d8672bda4059c794e099ba3f5a8fa
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

RAMP3 ARHGAP31 SLC22A10 PTCHD4 HYAL2

4.31e-05187925fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 CP DCN PLP1 GNRHR

4.54e-05189925a5306561026e4dfcc39beeb785e5108ac595d136
ToppCellfacs-BAT-Fat-18m-Mesenchymal|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.54e-05189925bba28f57a0708515fdd5acd9592dbbe4a4f57116
ToppCellfacs-BAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.54e-05189925cf293b23a4c0e8a0c9f09115b1d53d9b11de72e2
ToppCellfacs-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 CP DCN PLP1 GNRHR

4.54e-05189925381058f55908f84375b54601d617389ef43ab855
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 CP DCN PLP1 GNRHR

4.54e-05189925302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCellfacs-BAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.54e-0518992587323e86a5b5d159920a07e6bd7ef5e3438cd085
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 PTCHD4 KIT CA3

4.65e-051909253b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN ARHGAP31 PTCHD4 KIT CA3

4.65e-05190925dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RELN RAMP3 ARHGAP31 IKBKB HYAL2

4.77e-05191925f663131a4810584c5854bd64ee7991a237b7707f
ToppCelldroplet-Lung-nan-21m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.77e-0519192592b2faa72c184b6ae49530fd3b50848510904997
ToppCellfacs-Aorta-Heart-18m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.77e-051919256242f83acaf1714e9c1771a832cb67674b19e96d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRHDE RELN SLC6A16 DCN SHISA6

4.77e-05191925de54dab85db70f847de75b3b6d7667a0e13b9bfb
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.77e-051919251efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCelldroplet-Lung-nan-21m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.77e-05191925d0bbbf42d00165a53253c833adef65da6ec36bba
ToppCellfacs-Aorta-Heart-18m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.89e-051929256d4fe7ea278efa4b9d43f8a3c282bc0e0e9abaea
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.89e-051929255e6f8206ee0b10cdba79a7c4a05452cb025a5512
ToppCelldroplet-Lung-nan-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.89e-0519292545929c757d873fe314cc36d27abd265414635490
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.89e-051929252c6406bc97c3224099b94a43f2890f057b528fa6
ToppCellfacs-Lung-3m-Mesenchymal|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EFEMP1 MRC2 LOXL2 CP DCN

4.89e-051929258df15085b35b86f39debd933284cb703c5dd63c2
ToppCellfacs-Aorta-Heart-18m-Mesenchymal-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.89e-0519292547aed7c8e6f5ce1084821212a04f568319e65fd6
ToppCelldroplet-Lung-nan-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP3 ARHGAP31 CA14 PTGS1 HYAL2

4.89e-05192925beb336d3479821bdab7e8e2c58812f155e44e9a2
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFEMP1 MRC2 LOXL2 CP DCN

4.89e-05192925136af0186c70c14c5f2b33ed7a148156de5b478c
Drugdimephosphon

CP DCN PTGS1

5.74e-075893CID000122179
DrugLGE2

LPA DCN PTGS1

3.19e-068893CID005771742
Drugnsc25485

PIKFYVE SLC24A4 LPA ENTPD3 PKD1 PKD1L3 ATP2B3 PIK3R5 CA3

3.69e-06312899CID000004605
Druglavendustin A

PIKFYVE CACNA1D PKD1 IKBKB PKD1L3 PIK3R5 GNRHR

4.89e-06171897CID000003894
DrugAC1L1KS5

SORT1 PIKFYVE CACNA1D ENTPD3 PKD1 PKD1L3 DCN ATP2B3 PTGS1

6.41e-06334899CID000005631
Drugglyphosine

IFT88 PKD1 PKHD1 PKD1L3

7.21e-0632894CID000017112
DrugNiridazole [61-57-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A

TYRP1 BBS7 MYOZ3 KMT2A GSAP IKBKB DCN

1.12e-051948973301_UP
DrugBrompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A

SORT1 LOXL2 APOBEC2 DNAH17 ELAPOR1 CA14 CHRNE

1.32e-051998973271_UP
Drugfluproquazone

DCN PTGS1

1.51e-052892CID000038503
Drugdalargin

DCN PTGS1

1.51e-052892CID005485190
Druglanthanum

CACNA1D LPA ENTPD3 PKD1 PKD1L3 ATP2B3

1.57e-05136896CID000023926
DrugAC1L1DXE

SORT1 PIKFYVE CACNA1D NPY5R PKD1 PKD1L3 PIK3R5 PTGS1

2.26e-05299898CID000002548
Drugsuprofen

CP DCN PTGS1

3.77e-0517893CID000005359
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A

SORT1 IGF2R EFEMP1 LOXL2 TRAM2 SORL1

4.08e-051618963556_DN
Drugpioglitazone

PIKFYVE LPA INSRR PKD1 PKD1L3 PIK3R5 PTGS1 CFHR4

4.18e-05326898CID000004829
Drugdiucifon

DCN PTGS1

4.52e-053892CID000122139
Drugitazigrel

DCN PTGS1

4.52e-053892CID000051087
Drugnesodine

DCN PTGS1

4.52e-053892CID006475455
Druganisodine hydrobromide

DCN PTGS1

4.52e-053892CID000123673
DrugAC1L1KM2

DCN PTGS1

4.52e-053892CID000005557
Drugdroxicam

DCN PTGS1

4.52e-053892CID000065679
Drugacexamic acid

DCN PTGS1

4.52e-053892CID000002005
Drug1a, 1b-dihomo-PGF2

DCN PTGS1

4.52e-053892CID006443812
Drug5-ethyl-4-methoxy-2-phenylquinoline

DCN PTGS1

4.52e-053892CID010400536
Drug2-propionyloxybenzoic acid

DCN PTGS1

4.52e-053892CID000095938
DrugAHR-10037

DCN PTGS1

4.52e-053892CID000132843
DrugSKF 105685

DCN PTGS1

4.52e-053892CID000121957
Drugsodium rosmarinate

CCR3 IKBKB DCN PTGS1

5.52e-0553894CID000005099
Drugsodium linoleate

LPA ELOVL1 LRP6 IKBKB DCN PTGS1 SORL1 CFHR4

5.86e-05342898CID000003931
DrugAC1L2P35

DCN KIT PTGS1

6.27e-0520893CID000125736
Druglisofylline

IL12RB1 LARS1 DCN PTGS1

6.39e-0555894CID000057782
Drugfelbinac

CCR3 DCN PTGS1

7.30e-0521893CID000003332
Drugcarbachol

PIKFYVE CACNA1D TYRP1 LPA PKD1 PKD1L3 DCN ATP2B3 PIK3R5 PTGS1 CHRNE

7.61e-056888911CID000002551
DrugBM 13.177

ENTPD3 DCN PTGS1

8.43e-0522893CID000051550
Drugnimesulide

CACNA1D PSG5 DCN PTGS1 MEGF11

8.56e-05114895CID000004495
Drugmonomethyl phthalate

SORT1 TYRP1 IGF2R EFEMP1 PPP4C IFT88 ARHGAP31 MRC2 LOXL2 KMT2A CP ZP4 GNRHR

8.58e-059578913ctd:C517284
Drugheptadecatrienoic acid

DCN PTGS1

9.02e-054892CID016061034
DrugAC1L1D1U

DCN PTGS1

9.02e-054892CID000002158
DrugAI-122

DCN PTGS1

9.02e-054892CID000134058
Drugfentiazac

DCN PTGS1

9.02e-054892CID000028871
Drugselezen

DCN PTGS1

9.02e-054892CID000037425
DrugFR122047

DCN PTGS1

9.02e-054892CID000196840
DrugAC1L2O1K

DCN PTGS1

9.02e-054892CID000125126
Drug2-chloropyridine

DCN PTGS1

9.02e-054892CID000007977
DrugEufans

DCN PTGS1

9.02e-054892CID000065655
Drugibuproxam

DCN PTGS1

9.02e-054892CID000068704
Drug2-(6-carboxyhexyl)cyclopentanone hexylhydrazone

DCN PTGS1

9.02e-054892CID000134996
Druganolignan B

PPP4C PTGS1

9.02e-054892CID000072388
Drug8beta-prostane

DCN PTGS1

9.02e-054892CID000107873
DrugSC57666

DCN PTGS1

9.02e-054892CID000443373
Druglamotrigine

CACNA1D LOXL2 PKD1 PKD1L3 PTGS1

9.29e-05116895CID000003878
DrugNiflumic acid [4394-00-7]; Up 200; 14.2uM; MCF7; HT_HG-U133A

TYRP1 APOBEC2 LRP6 GSAP DCN PTGS1

9.63e-051888965490_UP
Drugdazoxiben

ENTPD3 DCN PTGS1

9.66e-0523893CID000053000
Drugadrenic acid

NPHP3 DCN PTGS1

9.66e-0523893CID000002033
Drugfeprazone

DCN PTGS1 CFHR4

1.10e-0424893CID000035455
DrugPiperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A

SORT1 MRC2 ENTPD3 LRP6 KMT2A KIT

1.11e-041938963845_UP
DrugMethyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A

LOXL2 LRP6 KMT2A IKBKB PIK3R5 PTGS1

1.11e-041938963850_UP
DrugMegestrol acetate [595-33-5]; Up 200; 10.4uM; MCF7; HT_HG-U133A

SLC6A16 APOBEC2 IKBKB KIT GNRHR PTGS1

1.21e-041968966468_UP
DrugAntipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; MCF7; HT_HG-U133A

LOXL2 APOBEC2 LRP6 MYOZ3 KCNK12 PIK3R5

1.21e-041968961497_UP
DrugAllantoin [97-59-6]; Up 200; 25.2uM; MCF7; HT_HG-U133A

SLC6A16 LMTK2 LRP6 GSAP IKBKB PTGS1

1.32e-041998965471_UP
DrugLeucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A

IL12RB1 LRP6 KCNK12 GSAP DCN PTGS1

1.32e-041998966767_UP
Drug(cis-) Nanophine [5072-45-7]; Up 200; 26.8uM; MCF7; HT_HG-U133A

TRHDE RELN RAMP3 MYOZ3 ASTN1 CHRNE

1.35e-042008966049_UP
DrugGuanadrel sulfate [22195-34-2]; Up 200; 7.6uM; HL60; HT_HG-U133A

SLC6A16 MRC2 LRP6 KMT2A PLP1 GNRHR

1.35e-042008962575_UP
DrugDipivefrin hydrochloride [64019-93-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A

RELN APOBEC2 DNAH17 LRP6 MYOZ3 DCN

1.35e-042008966766_UP
DrugLiothyronine [6893-02-3]; Up 200; 6.2uM; HL60; HT_HG-U133A

SORT1 SLC6A16 LPA DNAH17 KIT GNRHR

1.35e-042008962984_UP
Drug14,15-DHET

LPA DCN PTGS1

1.41e-0426893CID005283147
DrugONO-3708

ENTPD3 DCN PTGS1

1.41e-0426893CID005311334
Drug4,4'-bipyridine

PPP4C DCN PTGS1

1.41e-0426893CID000011107
Drugsimvastatin

PIKFYVE LPA LRP6 CCR3 IKBKB PIK3R5 SORL1 CFHR4

1.45e-04390898CID000054454
Drugnictindole

DCN PTGS1

1.50e-045892CID000065796
DrugPP56

DCN PTGS1

1.50e-045892CID000065762
Drug4-methylesculetin

DCN PTGS1

1.50e-045892CID005319502
DrugAC1Q5RRW

DCN PTGS1

1.50e-045892CID000039940
Drugfenflumizole

DCN PTGS1

1.50e-045892CID000068917
Drugethonium

DCN PTGS1

1.50e-045892CID000030869
Drug1-octanoyl-2-acetylglycerol

DCN PTGS1

1.50e-045892CID000130710
Drug4'-piperidinoacetophenone

DCN PTGS1

1.50e-045892CID000082561
DrugPGF-M

DCN PTGS1

1.50e-045892CID003082337
Drugetofenamate

DCN PTGS1

1.50e-045892CID000035375
Drugursolic acid

PIKFYVE DCN PIK3R5 PTGS1

1.83e-0472894CID000064945
Drugcaged InsP3

SORT1 PKD1 PKD1L3

1.96e-0429893CID000122248
Drugmonatepil

LPA LRP6 SORL1

1.96e-0429893CID000060810
Drugmethanesulfonamide

DCN GNRHR PTGS1

2.17e-0430893CID000072879
Drugproglumetacin

DCN PTGS1

2.24e-046892CID000004921
DrugKBT-3022

DCN PTGS1

2.24e-046892CID000065870
DrugMesalazine

IKBKB PTGS1

2.24e-046892DB00244
DrugMK-410

DCN PTGS1

2.24e-046892CID006451644
Drugbupirimate

GSAP MEGF11

2.24e-046892CID000038884
Drugdesproglumideproglumetacin

DCN PTGS1

2.24e-046892CID000126678
DrugNSC-126225

LPA CP

2.24e-046892CID000005500
Drugoxindanac

DCN PTGS1

2.24e-046892CID000068879
Drugfenbufen

DCN PTGS1

2.24e-046892CID000003335
Drugfenclofenac

DCN PTGS1

2.24e-046892CID000065394
Drug15-hydroperoxy-PGE2

DCN PTGS1

2.24e-046892CID006444110
DrugBMY 30094

DCN PTGS1

2.24e-046892CID000188382
DrugNpc-16731

DCN PTGS1

2.24e-046892CID003081250
Drugorpanoxin

DCN PTGS1

2.24e-046892CID000043382
DrugCID11006516

PPP4C PTGS1

2.24e-046892CID011006516
DrugS35b

DCN PTGS1

2.24e-046892CID000193841
Drugamiloride

CACNA1D SLC24A4 LOXL2 PKD1 SLC19A2 PKD1L3 CA3

2.37e-04315897CID000016230
DiseaseAutosomal Recessive Polycystic Kidney Disease

NPHP3 IFT88 PKHD1

2.05e-069873C0085548
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

NPHP3 IFT88 PKD1

8.80e-0614873DOID:898 (implicated_via_orthology)
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

IFT88 PKD1 PKHD1

1.35e-0516873DOID:0110861 (implicated_via_orthology)
Diseasecorneal resistance factor

NPHP3 EFEMP1 LOXL2 LRP6 KMT2A CCR3 TRAM2 DCN

5.70e-05451878EFO_0010067
DiseaseAcute myelomonocytic leukemia

KMT2A KIT

8.54e-055872C0023479
DiseaseConn Syndrome

CACNA1D ATP2B3

1.28e-046872C1384514
Diseaseoligoasthenoteratozoospermia (implicated_via_orthology)

PPP4C CFAP61

1.28e-046872DOID:0070311 (implicated_via_orthology)
DiseaseHyperaldosteronism

CACNA1D ATP2B3

1.28e-046872C0020428
Diseaseintraocular pressure measurement

RELN NPHP3 EFEMP1 PKHD1 KMT2A TRAM2 DCN CHRNE

1.32e-04509878EFO_0004695
DiseaseCarcinoma, Granular Cell

TYRP1 EFEMP1 KMT2A GKN1

3.93e-04116874C0205644
DiseaseAdenocarcinoma, Tubular

TYRP1 EFEMP1 KMT2A GKN1

3.93e-04116874C0205645
DiseaseAdenocarcinoma, Oxyphilic

TYRP1 EFEMP1 KMT2A GKN1

3.93e-04116874C0205642
DiseaseCarcinoma, Cribriform

TYRP1 EFEMP1 KMT2A GKN1

3.93e-04116874C0205643
DiseaseAdenocarcinoma, Basal Cell

TYRP1 EFEMP1 KMT2A GKN1

3.93e-04116874C0205641
DiseaseAdenocarcinoma

TYRP1 EFEMP1 KMT2A GKN1

3.93e-04116874C0001418
DiseaseDisorder of eye

TYRP1 NPHP3 EFEMP1 KLHL7 BBS7

4.18e-04212875C0015397
Diseasepigmentation disease (is_implicated_in)

TYRP1 SLC24A4

4.65e-0411872DOID:10123 (is_implicated_in)
Diseasemood disorder

RELN SORL1

6.56e-0413872EFO_0004247
Diseaseschizophrenia (implicated_via_orthology)

CACNA1D RELN ASTN1

1.08e-0368873DOID:5419 (implicated_via_orthology)
Diseaseserum alanine aminotransferase measurement, response to combination chemotherapy

RNF213 CSMD2 CFHR4

1.22e-0371873EFO_0004735, EFO_0007965
DiseaseMalignant neoplasm of breast

EFEMP1 LOXL2 ELAPOR1 NDUFA8 IKBKB GKN1 KIT ZDHHC4 PTGS1 SORL1

1.24e-0310748710C0006142
Diseasebipolar disorder (is_marker_for)

RELN PTGS1

1.42e-0319872DOID:3312 (is_marker_for)
Diseaseskin aging measurement

EFEMP1 SLC24A4 KLHL7 PKD1L3

2.05e-03181874EFO_0008006
Diseasespermatogenic failure (is_implicated_in)

SHOC1 CFAP61

2.09e-0323872DOID:0111910 (is_implicated_in)
Diseasecentral corneal thickness

EFEMP1 LOXL2 KMT2A TRAM2 DCN

2.24e-03309875EFO_0005213
DiseaseHepatolenticular Degeneration

LOXL2 CP

2.27e-0324872C0019202
DiseaseHepatic Form of Wilson Disease

LOXL2 CP

2.27e-0324872C1527352
Diseasehair color

TYRP1 EML5 SLC24A4 LINC02898 PKHD1

2.30e-03311875EFO_0003924
Diseasesleep duration, low density lipoprotein cholesterol measurement

IGF2R LPA PKD1L3

2.49e-0391873EFO_0004611, EFO_0005271

Protein segments in the cluster

PeptideGeneStartEntry
YLAWAICNFTYRETT

TRHDE

331

Q9UKU6
LSTYTYPWQAQAECV

nan

116

Q6ZRU5
ACRDYWTYQGSFTTP

CA3

186

P07451
TCSIIWSEYIAGEYT

CATSPERG

401

Q6ZRH7
SYDEIVVSTYSGWVT

BBS7

301

Q8IWZ6
ITDLYSYFTEPWCLA

CFAP61

1136

Q8NHU2
YPNYANCTWTITAEE

CSMD2

46

Q7Z408
TWLAECTPVYVQYFV

ATP2B3

401

Q16720
QEAIYGFEESCSIWY

ASTN1

866

O14525
RYNVTWYVSSSPCAA

APOBEC2

116

Q9Y235
SVCAVEVTYFPFDWQ

CHRNE

146

Q04844
LDAGSSRTTVYVYQW

ENTPD3

61

O75355
WAVCRDSVYYTISVI

SLC24A4

201

Q8NFF2
WCNLSEFIVYYESFT

RAMP3

56

O60896
WADTATVIQDYNYCR

MEN1

346

O00255
DSACIPWAYYSTVDQ

CP

871

P00450
FDQIYYTRCTDILNW

MEGF11

46

A6BM72
YVQNWESYTGRCPDV

HYAL2

216

Q12891
GAYATFIVTNYWESC

NMRAL1

71

Q9HBL8
VTVDYWSFGTLAFEC

IKBKB

201

O14920
IFNCVYTFESDVWSY

KIT

841

P10721
TAVIYEVQATCWYGA

CFAP65

311

Q6ZU64
YEYTACDSTGSRWRV

ELAPOR1

56

Q6UXG2
RVEVYYDGQWGTVCD

LOXL2

71

Q9Y4K0
YTFTSYDINWVRQAT

IGHV1-8

46

P0DP01
TSVEGWDYVDSLYFC

KCNK12

236

Q9HB15
LACTDTWVYEYTVFL

OR2L5

186

Q8NG80
YWEIQPSTFRCVYVR

DCN

336

P07585
DVLSCEYYSPTLDQW

KLHL9

511

Q9P2J3
RYIYWTCEATNVINV

LRP6

1026

O75581
SCYWLGEDQVTYSEA

MRC2

531

Q9UBG0
EQPYSDRWYEVLQFC

LMTK2

376

Q8IWU2
ALYLFECYDTRTESW

KLHL7

396

Q8IXQ5
ISWESFSNVSYYTRI

PTGS1

136

P23219
YTESSIYTSERFQNW

RELN

1711

P78509
STRDYFAEQVYWSPL

PIKFYVE

1076

Q9Y2I7
EFIIASSYWSVYSET

GSAP

466

A4D1B5
YSGTCYTTSVLWIVD

GKN1

161

Q9NS71
ESYRYFPCNIEVIEW

IFT88

611

Q13099
VECYNLETNEWRYVS

KLHL14

441

Q9P2G3
AFATSFTVCWTPYYV

GNRHR

271

P30968
TLCSALYPEDTVYSW

CCR3

181

P51677
DTICFIWATSEYYNT

DNAH17

316

Q9UFH2
LTVQCVYRSGWETYL

CD300LF

36

Q8TDQ1
ESETFIVYLCSYFWN

LINC02898

106

Q6ZV80
YTTDPSVRWEYCNLT

LPA

1001

P08519
LSTYTWRCDPVDYSN

ELOVL1

86

Q9BW60
LPWSRVEYQCQSYYE

CFHR4

231

Q92496
SSDRYECSWQYEGPT

IL12RB1

56

P42701
TYQYESWRCVTAERC

INSRR

266

P14616
PIGYQCSRVYWSTTD

KMT2A

2046

Q03164
YICIWDSYTVQTISV

EML5

86

Q05BV3
YICIWDSYNVQTVSL

EML6

86

Q6ZMW3
VYIACSFTTVWLIYS

KDELR1

66

P24390
CYQSVLWTVFYRRSQ

CA14

221

Q9ULX7
DTVGNIWVCYASYVV

SLC19A2

381

O60779
PFTEYWTCIDYTGQQ

NDUFA8

81

P51970
CYEDDSSPTWSRQNY

CACNA1D

1851

Q01668
YQTEYRWEVYRTASC

PKD1

2181

P98161
EETITYTQCTDGYEW

EFEMP1

21

Q12805
TEEDRGNYYCVVSAW

PTGFRN

506

Q9P2B2
PVFTGEVDCTYFFTW

IGF2R

446

P11717
TSDCSYLFEWRTQYA

IGF2R

1346

P11717
YSVEVRTTAYNVWAV

TAS2R31

76

P59538
TTAQYSFWLYELCDV

VARS1

1011

P26640
CWQTYTFTRDPIYFT

SORT1

556

Q99523
CARSSPVDYFWYRET

SLC6A19

166

Q695T7
CVYNVYYRVVGESIW

SORL1

1586

Q92673
ECERTTPSIYFWYQQ

SLC6A16

236

Q9GZN6
NYPWYGNTTETCTIV

FAM78A

131

Q5JUQ0
WSNTVRCYLIYTDET

NPHP3

296

Q7Z494
ITTDVNPYYDSFVRW

LARS1

206

Q9P2J5
CVDGWVYDQSYFPST

SLC22A10

116

Q63ZE4
YLCVESWPSDSYRIA

NPY5R

196

Q15761
LCSGFTAVSWVEQYY

PTCHD4

541

Q6ZW05
VSVITAVTQCYYWEI

PKD1L3

626

Q7Z443
SFVVEYNYVEDSCWT

SHOC1

811

Q5VXU9
SAAVTYETCWGYYDV

SHISA6

86

Q6ZSJ9
LESWPYLYICEESSQ

PKHD1

1831

P08F94
SVVQSYFVYWARIES

REELD1

146

A0A1B0GV85
YFVYWARIESSVVSQ

REELD1

151

A0A1B0GV85
GVALIWATYYESCIS

SSH1

201

Q8WYL5
LWEFCSETFQRPYQY

RNF213

2156

Q63HN8
GYTYEIQWPSREFSV

TYRP1

461

P17643
ARCYTYSWSQDSFDI

PIK3R5

286

Q8WYR1
TSVIWCFYVVVTEGY

TRAM2

126

Q15035
TEYTWEVFGYCQELE

ZDHHC4

81

Q9NPG8
YVRYWFTCTTEVDGT

ZBED8

11

Q8IZ13
TSSYCKADPWRVYSQ

ARHGAP31

1146

Q2M1Z3
TYYRIFTWRFPSTIC

GTF3C1

1506

Q12789
SVTVWRYCTEIFDYL

PPP4C

136

P60510
ETVLTVWSAPNYCYR

PPP4C

251

P60510
AFTCEPKSENYTYIW

PSG5

166

Q15238
VLEATYSSCYVTEWD

ZP4

86

Q12836
YVLTRPCWSRSQDSY

ZAN

1566

Q9Y493
CPWQEFVSYRDYQSD

MYOZ3

166

Q8TDC0
AVPVYIYFNTWTTCQ

PLP1

171

P60201