Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Ion_trans_dom	TRPC7 CNGB3	1.17e-02	114	27	2	IPR005821
Domain	Ion_trans	TRPC7 CNGB3	1.17e-02	114	27	2	PF00520
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	RNF139 ESYT1 UGGT1 TM9SF3	4.23e-05	235	29	4	32614325
Pubmed	Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.	GRB10 PTP4A1	6.07e-05	14	29	2	23106268
Pubmed	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.	GRB10 ESYT1	9.06e-05	17	29	2	21779181
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	PIGU RIOK2 ESYT1 TM9SF3	1.07e-04	299	29	4	37931956
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	KDM5B SLC39A8	3.28e-04	32	29	2	14613977
Pubmed	Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.	CAND1 ESYT1 UGGT1	4.09e-04	174	29	3	32149426
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	PIGU ESYT1 UGGT1 TM9SF3	5.89e-04	468	29	4	31056421
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GRB10 KDM5B PLCH1 ESYT1 DOP1A	6.66e-04	861	29	5	36931259
Pubmed	Genetic variants influencing circulating lipid levels and risk of coronary artery disease.	GFOD2 SLC39A8	7.71e-04	49	29	2	20864672
Cytoband	3q29	SLC51A SENP5	1.27e-03	83	29	2	3q29
Cytoband	Ensembl 112 genes in cytogenetic band chr3q29	SLC51A SENP5	3.40e-03	137	29	2	chr3q29
Cytoband	Ensembl 112 genes in cytogenetic band chr2q14	GYPC UGGT1	4.89e-03	165	29	2	chr2q14
Coexpression	GSE17301_CTRL_VS_48H_IFNA2_STIM_CD8_TCELL_UP	GRB10 GVINP1 ESYT1 DOP1A TM9SF3	2.10e-06	200	28	5	M8038
Disease	Abnormality of chromosome segregation	PLCH1 PTP4A1	1.38e-03	60	27	2	HP_0002916
Disease	systemic scleroderma	GRB10 ESYT1	2.75e-03	85	27	2	EFO_0000717
Disease	alcohol use disorder measurement, alcohol consumption measurement	PLCH1 SLC39A8	3.56e-03	97	27	2	EFO_0007878, EFO_0009458
Disease	cortical thickness, neuroimaging measurement	GRB10 SLC39A8	4.55e-03	110	27	2	EFO_0004346, EFO_0004840
Disease	choline measurement	PLCH1 SLC39A8	6.29e-03	130	27	2	EFO_0010116
Disease	glycine measurement	GVINP1 SLC39A8	6.96e-03	137	27	2	EFO_0009767
Disease	insomnia measurement	TRPC7 PLCH1 SLC39A8	7.52e-03	443	27	3	EFO_0007876
Disease	severe acute respiratory syndrome, COVID-19	GRB10 TRPC7 GYPC	7.71e-03	447	27	3	EFO_0000694, MONDO_0100096
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	RNF139 RIOK2	8.08e-03	148	27	2	C0279702

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLYMKLVMRILYLDS	ESYT1	586	Q9BSJ8
RLNRYKMIRLLIMYG	ANKRD1	261	Q15327
FYFLQKLLMMDYELR	GVINP1	901	Q7Z2Y8
KLLMMDYELRYLVFK	GVINP1	906	Q7Z2Y8
MYIEILISLCLYYMR	DOP1A	1451	Q5JWR5
IRRFLLAYKMMLEFF	OGFRL1	191	Q5TC84
HYDIKMLTFLMLVRL	CAND1	1116	Q86VP6
KLRYRYTLDDLYPMM	KDM5B	731	Q9UGL1
MEMRYIPLKVALFYL	PIGU	131	Q9H490
TFLMTVLTRMYYRRK	SLC51A	306	Q86UW1
ALIMFYLYAITLLML	OTOP1	346	Q7RTM1
LLYLKGMVYMVQALR	GFOD2	301	Q3B7J2
MTAFRLLKYGMLLYQ	GRB10	391	Q13322
IVLVSLLFVMLRYMY	GYPC	71	P04921
LLFVMLRYMYRHKGT	GYPC	76	P04921
LLRAKAMRLLYYLKT	PTCHD3	316	Q3KNS1
MLLYLMGLSRLISYK	OR10D3	81	Q8NH80
LYSLIMSRTVYLKMA	OR5F1	131	O95221
LVRHMYRIYGLQLLM	RNF139	211	Q8WU17
SVFLRLEYLQMLYMR	PRAMEF19	261	Q5SWL8
LEYLQMLYMRRIRFF	PRAMEF19	266	Q5SWL8
MLYMRRIRFFEGYLD	PRAMEF19	271	Q5SWL8
QMIYDMLLRLKSVLY	CNGB3	531	Q9NQW8
MMYEKLSMIRFRYRI	SENP5	231	Q96HI0
FKYVRMLGALYMRLT	PRPF38A	96	Q8NAV1
IIYMDRYMYRSKELI	USP28	391	Q96RU2
LYLSRLSAMKEFAYM	RIOK2	151	Q9BVS4
VFYKMMSLRRDLYLL	PLCH1	206	Q4KWH8
SMILMRTLRKDYARY	TM9SF3	241	Q9HD45
FYLLFFFERMLKMLL	SLC39A8	206	Q9C0K1
LLYLEKYRPKMRLRF	PTP4A1	146	Q93096
LYERFLRIMMLSVLK	UGGT1	1266	Q9NYU2
KSFYYLIMRIKMCLI	TRPC7	716	Q9HCX4