Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of tooth enamel	AMELX AMELY	3.96e-05	6	33	2	GO:0030345
GeneOntologyMolecularFunction	hydroxyapatite binding	AMELX AMELY	7.37e-05	8	33	2	GO:0046848
GeneOntologyMolecularFunction	sodium ion binding	AMELX AMELY	2.38e-04	14	33	2	GO:0031402
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring compression resistance	AMELX AMELY	6.56e-04	23	33	2	GO:0030021
GeneOntologyMolecularFunction	alkali metal ion binding	AMELX AMELY	8.40e-04	26	33	2	GO:0031420
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	CUL4A STING1 HERC2 SNX9	2.22e-03	337	33	4	GO:0031625
GeneOntologyBiologicalProcess	tooth mineralization	AMELX AMELY BCOR	2.76e-05	38	32	3	GO:0034505
MousePheno	short Tomes' process	AMELX AMELY	3.87e-06	2	28	2	MP:0030513
MousePheno	abnormal Tomes' process morphology	AMELX AMELY	1.16e-05	3	28	2	MP:0030512
MousePheno	large mandible	AMELX AMELY	2.32e-05	4	28	2	MP:0030050
MousePheno	enamel pits	AMELX AMELY	3.85e-05	5	28	2	MP:0030460
MousePheno	short upper incisors	AMELX AMELY	5.77e-05	6	28	2	MP:0030090
MousePheno	small upper incisors	AMELX AMELY	8.07e-05	7	28	2	MP:0030081
MousePheno	short lower incisors	AMELX AMELY	8.07e-05	7	28	2	MP:0030089
MousePheno	abnormal enamel rod pattern	AMELX AMELY	1.08e-04	8	28	2	MP:0002649
MousePheno	abnormal tooth wear	AMELX AMELY	1.72e-04	10	28	2	MP:0030458
MousePheno	small lower incisors	AMELX AMELY	2.10e-04	11	28	2	MP:0030080
MousePheno	brittle teeth	AMELX AMELY	2.52e-04	12	28	2	MP:0000126
MousePheno	reduced enamel thickness	AMELX AMELY	2.52e-04	12	28	2	MP:0002577
MousePheno	increased lung tissue damping	AMELX AMELY	2.98e-04	13	28	2	MP:0011047
MousePheno	abnormal enamel mineralization	AMELX AMELY	2.98e-04	13	28	2	MP:0030450
MousePheno	short incisors	AMELX AMELY	3.47e-04	14	28	2	MP:0004830
MousePheno	abnormal lung tissue damping	AMELX AMELY	4.56e-04	16	28	2	MP:0011046
MousePheno	abnormal molar cusp morphology	AMELX AMELY	4.56e-04	16	28	2	MP:0030457
MousePheno	abnormal incisor color	AMELX AMELY	4.56e-04	16	28	2	MP:0010096
MousePheno	abnormal upper incisor morphology	AMELX AMELY	6.48e-04	19	28	2	MP:0030137
MousePheno	absent teeth	AMELX AMELY	7.19e-04	20	28	2	MP:0030610
MousePheno	increased urine calcium level	GCM2 MMUT	8.72e-04	22	28	2	MP:0005441
MousePheno	small incisors	AMELX AMELY	8.72e-04	22	28	2	MP:0030079
MousePheno	abnormal molar crown morphology	AMELX AMELY	8.72e-04	22	28	2	MP:0003932
MousePheno	abnormal ameloblast morphology	AMELX AMELY	8.72e-04	22	28	2	MP:0002650
MousePheno	abnormal lower incisor morphology	AMELX AMELY	1.13e-03	25	28	2	MP:0030136
MousePheno	abnormal tooth mineralization	AMELX AMELY	1.22e-03	26	28	2	MP:0002817
MousePheno	microdontia	AMELX AMELY	1.22e-03	26	28	2	MP:0030088
Domain	Amelogenin	AMELX AMELY	2.67e-06	2	31	2	IPR004116
Domain	Amelogenin	AMELX AMELY	2.67e-06	2	31	2	SM00818
Domain	Amelogenin	AMELX AMELY	2.67e-06	2	31	2	PF02948
Domain	MetalloPept_cat_dom	MMP16 MIPEP	7.96e-03	81	31	2	IPR024079
Domain	-	MMP16 MIPEP	7.96e-03	81	31	2	3.40.390.10
Domain	WD40_repeat	DNAI4 NOL10 HERC2	1.02e-02	272	31	3	IPR001680
Domain	WD_REPEATS_1	DNAI4 NOL10 HERC2	1.08e-02	278	31	3	PS00678
Domain	WD_REPEATS_2	DNAI4 NOL10 HERC2	1.09e-02	279	31	3	PS50082
Domain	WD_REPEATS_REGION	DNAI4 NOL10 HERC2	1.09e-02	279	31	3	PS50294
Domain	ZINC_PROTEASE	MMP16 MIPEP	1.15e-02	98	31	2	PS00142
Pubmed	Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel.	AMELX AMELY GLI1	2.72e-08	7	33	3	28081373
Pubmed	Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse.	AMELX AMELY AR	2.21e-07	13	33	3	8012115
Pubmed	BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor.	AMELX AMELY GLI1	7.46e-07	19	33	3	22629441
Pubmed	Amelogenin-deficient mice display an amelogenesis imperfecta phenotype.	AMELX AMELY	8.73e-07	2	33	2	11406633
Pubmed	The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice.	AMELX AMELY	8.73e-07	2	33	2	12851394
Pubmed	Amelogenin, the major protein of tooth enamel: a new phylogenetic marker for ordinal mammal relationships.	AMELX AMELY	8.73e-07	2	33	2	18346915
Pubmed	Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6.	AMELX AMELY	8.73e-07	2	33	2	29337060
Pubmed	Molecular cloning and DNA sequence of rat amelogenin and a comparative analysis of mammalian amelogenin protein sequence divergence.	AMELX AMELY	8.73e-07	2	33	2	8297387
Pubmed	Thermal denaturation of a recombinant mouse amelogenin: circular dichroism and differential scanning calorimetric studies.	AMELX AMELY	8.73e-07	2	33	2	16284958
Pubmed	SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression.	AR SF3B2	8.73e-07	2	33	2	31431456
Pubmed	Human and mouse amelogenin gene loci are on the sex chromosomes.	AMELX AMELY	8.73e-07	2	33	2	2737677
Pubmed	A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride.	AMELX AMELY	8.73e-07	2	33	2	19086270
Pubmed	Molecular structure of the mouse amelogenin genomic DNA.	AMELX AMELY	8.73e-07	2	33	2	8988368
Pubmed	Hierarchical self-assembly of amelogenin and the regulation of biomineralization at the nanoscale.	AMELX AMELY	8.73e-07	2	33	2	21825148
Pubmed	Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture.	AMELX AMELY	8.73e-07	2	33	2	12489164
Pubmed	Amelogenin: a potential regulator of cementum-associated genes.	AMELX AMELY	8.73e-07	2	33	2	14653387
Pubmed	A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo.	AMELX AMELY	8.73e-07	2	33	2	7489712
Pubmed	The leucine-rich amelogenin protein (LRAP) is primarily monomeric and unstructured in physiological solution.	AMELX AMELY	8.73e-07	2	33	2	25449314
Pubmed	High-yield recombinant bacterial expression of 13 C-, 15 N-labeled, serine-16 phosphorylated, murine amelogenin using a modified third generation genetic code expansion protocol.	AMELX AMELY	8.73e-07	2	33	2	36585836
Pubmed	Isolation and characterization of a mouse amelogenin expressed in Escherichia coli.	AMELX AMELY	8.73e-07	2	33	2	8062146
Pubmed	Transgenic mice that express normal and mutated amelogenins.	AMELX AMELY	8.73e-07	2	33	2	17384027
Pubmed	Alternative splicing of the mouse amelogenin primary RNA transcript.	AMELX AMELY	8.73e-07	2	33	2	7820782
Pubmed	Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin.	AMELX AMELY	8.73e-07	2	33	2	26709694
Pubmed	Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta.	AMELX AMELY	8.73e-07	2	33	2	7782077
Pubmed	Comparison of body weight and gene expression in amelogenin null and wild-type mice.	AMELX AMELY	8.73e-07	2	33	2	16674684
Pubmed	Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6 Amelx-/- mice and Amelx+/- lyonization.	AMELX AMELY	8.73e-07	2	33	2	27896287
Pubmed	Amelogenin-collagen interactions regulate calcium phosphate mineralization in vitro.	AMELX AMELY	8.73e-07	2	33	2	20404336
Pubmed	Maintenance of amelogenin gene expression by transformed epithelial cells of mouse enamel organ.	AMELX AMELY	8.73e-07	2	33	2	1444889
Pubmed	Identification of the functional activity of the [A-4] amelogenin gene splice product in newborn mouse ameloblasts.	AMELX AMELY	8.73e-07	2	33	2	18394981
Pubmed	A solution NMR investigation into the impaired self-assembly properties of two murine amelogenins containing the point mutations T21→I or P41→T.	AMELX AMELY	8.73e-07	2	33	2	23896516
Pubmed	Stage-Specific Role of Amelx Activation in Stepwise Ameloblast Induction from Mouse Induced Pluripotent Stem Cells.	AMELX AMELY	8.73e-07	2	33	2	34281250
Pubmed	The X-Y homologous gene amelogenin maps to the short arms of both the X and Y chromosomes and is highly conserved in primates.	AMELX AMELY	8.73e-07	2	33	2	1427830
Pubmed	Transgene animal model for protein expression and accumulation into forming enamel.	AMELX AMELY	8.73e-07	2	33	2	11063035
Pubmed	Regulation of amelogenin gene expression.	AMELX AMELY	8.73e-07	2	33	2	10200911
Pubmed	Truncated amelogenin and LRAP transgenes improve Amelx null mouse enamel.	AMELX AMELY	8.73e-07	2	33	2	26607574
Pubmed	A human X-Y homologous region encodes "amelogenin".	AMELX AMELY	8.73e-07	2	33	2	2004775
Pubmed	Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice.	AMELX AMELY	8.73e-07	2	33	2	35219810
Pubmed	Of mice and men: anatomy of the amelogenin gene.	AMELX AMELY	8.73e-07	2	33	2	2689082
Pubmed	Altering biomineralization by protein design.	AMELX AMELY	8.73e-07	2	33	2	16707492
Pubmed	Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure.	AMELX AMELY	8.73e-07	2	33	2	21984897
Pubmed	The murine amelogenin promoter: developmentally regulated expression in transgenic animals.	AMELX AMELY	8.73e-07	2	33	2	9084642
Pubmed	Cryogenic transmission electron microscopy study of amelogenin self-assembly at different pH.	AMELX AMELY	8.73e-07	2	33	2	21597263
Pubmed	Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.	AMELX AMELY	8.73e-07	2	33	2	23948316
Pubmed	Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development.	AMELX AMELY	8.73e-07	2	33	2	8392462
Pubmed	Amelogenins as potential buffers during secretory-stage amelogenesis.	AMELX AMELY	8.73e-07	2	33	2	25535204
Pubmed	An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1.	AMELX AMELY	8.73e-07	2	33	2	20923441
Pubmed	Model system for evaluation of alternative splicing: exon skipping.	AMELX AMELY	8.73e-07	2	33	2	11879574
Pubmed	Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.	AMELX AMELY	8.73e-07	2	33	2	9878259
Pubmed	Analysis of self-assembly and apatite binding properties of amelogenin proteins lacking the hydrophilic C-terminal.	AMELX AMELY	8.73e-07	2	33	2	11852235
Pubmed	Amelogenin genes and sexual dimorphism of teeth in humans and mice.	AMELX AMELY	8.73e-07	2	33	2	1463023
Pubmed	Translocation of enamel proteins from inner enamel epithelia to odontoblasts during mouse tooth development.	AMELX AMELY	8.73e-07	2	33	2	8179220
Pubmed	Phosphorylation and ionic strength alter the LRAP-HAP interface in the N-terminus.	AMELX AMELY	8.73e-07	2	33	2	23477367
Pubmed	Protein interactions during assembly of the enamel organic extracellular matrix.	AMELX AMELY	8.73e-07	2	33	2	9041053
Pubmed	Highly acidic pH facilitates enamel protein self-assembly, apatite crystal growth and enamel protein interactions in the early enamel matrix.	AMELX AMELY	8.73e-07	2	33	2	36569763
Pubmed	Exon4 amelogenin transcripts in enamel biomineralization.	AMELX AMELY	8.73e-07	2	33	2	25792521
Pubmed	The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype.	AMELX AMELY	8.73e-07	2	33	2	18701811
Pubmed	Expression of amelogenin in odontoblasts.	AMELX AMELY	8.73e-07	2	33	2	12667550
Pubmed	Spatial- and temporal-restricted pattern for amelogenin gene expression during mouse molar tooth organogenesis.	AMELX AMELY	8.73e-07	2	33	2	3253061
Pubmed	The Combined Immunohistochemical Expression of GLI1 and BCOR in Synovial Sarcomas for the Identification of Three Risk Groups and Their Prognostic Outcomes: A Study of 52 Patients.	BCOR GLI1	8.73e-07	2	33	2	39062853
Pubmed	Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway.	AMELX AMELY	8.73e-07	2	33	2	19462488
Pubmed	Isolation and characterization of a pseudoautosomal region-specific genetic marker in C57BL/6 mice using genomic representational difference analysis.	AMELX AMELY	8.73e-07	2	33	2	8618899
Pubmed	A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta.	AMELX AMELY	8.73e-07	2	33	2	20067920
Pubmed	Novel LRAP-binding partner revealing the plasminogen activation system as a regulator of cementoblast differentiation and mineral nodule formation in vitro.	AMELX AMELY	8.73e-07	2	33	2	31621902
Pubmed	Reuptake of extracellular amelogenin by dental epithelial cells results in increased levels of amelogenin mRNA through enhanced mRNA stabilization.	AMELX AMELY	8.73e-07	2	33	2	16293627
Pubmed	Leucine rich amelogenin peptide alters ameloblast differentiation in vivo.	AMELX AMELY	8.73e-07	2	33	2	23747796
Pubmed	Evolution in tooth developmental biology: of morphology and molecules.	AMELX AMELY	8.73e-07	2	33	2	8769659
Pubmed	Amelogenin promotes odontoblast-like MDPC-23 cell differentiation via activation of ERK1/2 and p38 MAPK.	AMELX AMELY	8.73e-07	2	33	2	21547453
Pubmed	Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.	AMELX AMELY	8.73e-07	2	33	2	1445358
Pubmed	Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1).	AMELX AMELY	8.73e-07	2	33	2	11877393
Pubmed	BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation.	BCOR AR	8.73e-07	2	33	2	31925334
Pubmed	Partial rescue of the amelogenin null dental enamel phenotype.	AMELX AMELY	8.73e-07	2	33	2	18390542
Pubmed	Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T point mutations.	AMELX AMELY	8.73e-07	2	33	2	21540557
Pubmed	The energetic basis for hydroxyapatite mineralization by amelogenin variants provides insights into the origin of amelogenesis imperfecta.	AMELX AMELY	8.73e-07	2	33	2	31239344
Pubmed	Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis.	AMELX AMELY	8.73e-07	2	33	2	19097165
Pubmed	A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich Amelogenin Protein).	AMELX AMELY	8.73e-07	2	33	2	20304108
Pubmed	Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate.	AMELX AMELY	8.73e-07	2	33	2	24362885
Pubmed	Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro.	AMELX AMELY	8.73e-07	2	33	2	15647828
Pubmed	DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein.	AMELX AMELY	8.73e-07	2	33	2	4015654
Pubmed	Weaker dental enamel explains dental decay.	AMELX AMELY	8.73e-07	2	33	2	25885796
Pubmed	Structural variation of the pseudoautosomal region between and within inbred mouse strains.	AMELX AMELY	8.73e-07	2	33	2	8552598
Pubmed	The amelogenin C-terminus is required for enamel development.	AMELX AMELY	8.73e-07	2	33	2	20042744
Pubmed	Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice.	AMELX AMELY	8.73e-07	2	33	2	34780561
Pubmed	Comparison of upstream regions of X- and Y-chromosomal amelogenin genes.	AMELX AMELY	8.73e-07	2	33	2	9714776
Pubmed	Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor.	AMELX AMELY	8.73e-07	2	33	2	31919099
Pubmed	The small bovine amelogenin LRAP fails to rescue the amelogenin null phenotype.	AMELX AMELY	8.73e-07	2	33	2	12958690
Pubmed	[Types and frequencies of variants in Amelogenin gene in Chinese population].	AMELX AMELY	8.73e-07	2	33	2	18067069
Pubmed	The circadian clock modulates enamel development.	AMELX AMELY	8.73e-07	2	33	2	22653892
Pubmed	Cloning, characterization, and heterologous expression of exon-4-containing amelogenin mRNAs.	AMELX AMELY	8.73e-07	2	33	2	9062557
Pubmed	Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution.	AMELX AMELY	8.73e-07	2	33	2	15972588
Pubmed	Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma.	CUL4A GLI1	8.73e-07	2	33	2	26218750
Pubmed	Sonic hedgehog regulates growth and morphogenesis of the tooth.	AMELX AMELY GLI1	1.02e-06	21	33	3	11044393
Pubmed	Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.	AMELX AMELY GLI1	2.51e-06	28	33	3	32674056
Pubmed	Origin, splicing, and expression of rodent amelogenin exon 8.	AMELX AMELY	2.62e-06	3	33	2	16998127
Pubmed	Early determination and permissive expression of amelogenin transcription during mouse mandibular first molar development.	AMELX AMELY	2.62e-06	3	33	2	8026631
Pubmed	Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin.	AMELX AMELY	2.62e-06	3	33	2	18515207
Pubmed	Synergistic roles of amelogenin and ameloblastin.	AMELX AMELY	2.62e-06	3	33	2	19407150
Pubmed	Loss of androgen signaling in mesenchymal sonic hedgehog responsive cells diminishes prostate development, growth, and regeneration.	GLI1 AR	2.62e-06	3	33	2	31929563
Pubmed	A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel.	AMELX AMELY	2.62e-06	3	33	2	16674657
Pubmed	Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system.	AMELX AMELY	2.62e-06	3	33	2	16674683
Pubmed	Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells.	AMELX AMELY	2.62e-06	3	33	2	16674693
Interaction	CTBP1 interactions	CUL4A C15orf39 GRIN2D BCOR SNX9 AR MAN1B1	2.79e-06	406	32	7	int:CTBP1
Interaction	DAPK3 interactions	STING1 SNX9 AR CNTRL	1.16e-05	89	32	4	int:DAPK3
Interaction	KIF15 interactions	CUL4A STING1 HERC2 AR	1.44e-05	94	32	4	int:KIF15
Interaction	SMAD4 interactions	CDC42BPG GLI1 AR SF3B2 MMUT GAA HECTD4	1.59e-05	530	32	7	int:SMAD4
Interaction	ERG interactions	C15orf39 HERC2 BCOR AR SF3B2	2.50e-05	223	32	5	int:ERG
Interaction	HECTD4 interactions	HERC2 AR HECTD4	3.45e-05	40	32	3	int:HECTD4
Interaction	EIF3I interactions	CUL4A STING1 HERC2 GLI1 AR	5.02e-05	258	32	5	int:EIF3I
Interaction	CLTC interactions	STING1 GRIN2D HERC2 SNX9 AR MAN1B1 CNTRL	6.15e-05	655	32	7	int:CLTC
Interaction	FXR1 interactions	CUL4A HERC2 KIAA1549L BCOR GLI1 AR SF3B2	7.71e-05	679	32	7	int:FXR1
Interaction	CLXN interactions	HERC2 SNX9	8.73e-05	9	32	2	int:CLXN
Cytoband	11q13.1	CDC42BPG SF3B2	9.52e-04	63	33	2	11q13.1
GeneFamily	Ankyrin repeat domain containing	BCOR ANKRD53	2.63e-02	242	19	2	403
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B KIAA1549L ABCA12 PTPRZ1	5.82e-06	160	33	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B KIAA1549L ABCA12 PTPRZ1	5.82e-06	160	33	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
Computational	Developmental processes.	AMELX AMELY GCM2 GLI1 AR	2.92e-04	333	20	5	MODULE_220
Drug	ganoine	AMELX AMELY	6.11e-06	3	33	2	CID000131592
Drug	Fenofibrate [49562-28-9]; Up 200; 11uM; MCF7; HT_HG-U133A	CUL4A MUC5B BCOR ABCA12 FGGY	8.76e-06	196	33	5	7432_UP
Disease	amelogenesis imperfecta type 1E (implicated_via_orthology)	AMELX AMELY	1.07e-06	2	31	2	DOID:0110058 (implicated_via_orthology)
Disease	autosomal dominant hypocalcemia (biomarker_via_orthology)	AMELX AMELY	6.40e-06	4	31	2	DOID:0090109 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPPYPSYGYEPMGGW	AMELX	46	Q99217
LGYYPDPTFPAMAGW	EOMES	561	O95936
GYWYFMPPPPSSKVS	CNTRL	1141	Q7Z7A1
RPPYSSYGYEPMGGW	AMELY	61	Q99218
PGTYGMAAPWYFPIL	ABCA12	1276	Q86UK0
WVNPYMEGATPAIYP	BCOR	191	Q6W2J9
EWLDYSYPMPGPSGG	MUC5B	4136	Q9HC84
PAAPMGWGYAAPYLT	CDC42BPG	1316	Q6DT37
PRVWPYRMKVPQGFY	ANKRD53	461	Q8N9V6
GWRFTVYPIMPAAGP	HERC2	3701	O95714
PMPPWRSRAEYPGYN	GLI1	616	P08151
PRAGVQWVPTYRPEM	KIAA1549L	1601	Q6ZVL6
DVWYPGGMVSRVPYP	AR	501	P10275
MGIYYIPVLGPAPRW	NOL10	336	Q9BSC4
YTQWPDMGVPEYSLP	PTPRZ1	1896	P23471
WYPIDMLERPPAGYR	HECTD4	2401	Q9Y4D8
GAPWAVATTVVMYPP	MAN1B1	26	Q9UKM7
WYMPPDLYPSERYPV	B3GALT2	296	O43825
PIFVPGVWGPYFSAM	FGGY	306	Q96C11
GYWPTYTPMEVHLTP	CUL4A	531	Q13619
PPSVFYDWTPGMAVP	CERS1	131	P27544
DVVGYPFMPPYWGLG	GAA	356	P10253
PMWPERIYQSPYGVT	DNAI4	526	Q5VTH9
YLWMGYPPPAALVPS	C3orf56	86	Q8N813
PYWMSPEVISGEGYG	MAP3K3	531	Q99759
KIPIIVGDYGPMWVY	SNX9	231	Q9Y5X1
YYSLPNAVGPPFTWM	STING1	106	Q86WV6
YAPEDTGMSVYPEPW	GCM2	416	O75603
WTPYPPLYSTGMAGP	C15orf39	66	Q6ZRI6
PWLIAMQRYGPPPSY	SF3B2	631	Q13435
SEVMPWDPPYYSGVI	MIPEP	351	Q99797
GYPMQITYFWRGLPP	MMP16	376	P51512
FTRGPYPTMYTFRPW	MMUT	91	P22033
YAERLGPPPGRYWSV	GRIN2D	1141	O15399