Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGDP phosphatase activity

GBP1 GBP2 GBP3

9.96e-05121573GO:0004382
GeneOntologyMolecularFunctionspectrin binding

GBP1 GBP2 GBP3 PTPRC

1.42e-04341574GO:0030507
GeneOntologyMolecularFunctionhistone methyltransferase activity

PRDM2 SETD2 EHMT1 KMT2A PRMT7

2.42e-04711575GO:0042054
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

PRDM2 SETD2 EHMT1 KMT2A

3.91e-04441574GO:0140938
GeneOntologyMolecularFunctionhistone modifying activity

PRDM2 SETD2 HASPIN EHMT1 KMT2A PRKDC PRMT7 KAT6B

4.68e-042291578GO:0140993
GeneOntologyMolecularFunctionnucleoside diphosphate phosphatase activity

GBP1 GBP2 GBP3

4.93e-04201573GO:0017110
GeneOntologyBiologicalProcessAIM2 inflammasome complex assembly

GBP1 GBP2 GBP3 AIM2

2.27e-0781584GO:0140970
GeneOntologyBiologicalProcesspositive regulation of AIM2 inflammasome complex assembly

GBP1 GBP2 GBP3

1.75e-0641583GO:0140973
GeneOntologyBiologicalProcessregulation of AIM2 inflammasome complex assembly

GBP1 GBP2 GBP3

8.67e-0661583GO:0140971
GeneOntologyBiologicalProcesscytolysis in another organism

GBP1 GBP2 GBP3

3.58e-0591583GO:0051715
GeneOntologyBiologicalProcesspositive regulation of pyroptotic inflammatory response

GBP1 GBP2 GBP3

3.58e-0591583GO:0140639
GeneOntologyBiologicalProcessDNA biosynthetic process

PNKP PDGFB ING5 REV3L RRM1 STN1 NEK2 NAF1 DDX39B

4.80e-052181589GO:0071897
GeneOntologyBiologicalProcessDNA metabolic process

PNKP FMR1 PDGFB RTF2 ING5 TSN STOX1 REV3L XRCC2 SSRP1 RRM1 STN1 NEK2 SETD2 PTPRC NAF1 PRPF19 DCLRE1A PRKDC FH DDX39B

8.11e-05108115821GO:0006259
GeneOntologyBiologicalProcesscytolysis

GBP1 GBP2 GBP3

9.22e-05121583GO:0019835
GeneOntologyBiologicalProcessregulation of DNA biosynthetic process

PNKP PDGFB ING5 STN1 NEK2 NAF1 DDX39B

9.48e-051381587GO:2000278
GeneOntologyCellularComponenthost intracellular region

GBP1 GBP2 GBP3

8.65e-0661603GO:0043656
GeneOntologyCellularComponenthost cell cytoplasm

GBP1 GBP2 GBP3

8.65e-0661603GO:0030430
GeneOntologyCellularComponenthost cell part

GBP1 GBP2 GBP3

8.65e-0661603GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP1 GBP2 GBP3

8.65e-0661603GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP1 GBP2 GBP3

8.65e-0661603GO:0033655
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP1 GBP2 GBP3

8.65e-0661603GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP1 GBP2 GBP3

8.65e-0661603GO:0020005
GeneOntologyCellularComponentsymbiont cell surface

GBP1 GBP2 GBP3

2.40e-0581603GO:0106139
GeneOntologyCellularComponentother organism part

GBP1 GBP2 GBP3

3.57e-0591603GO:0044217
GeneOntologyCellularComponenthost cellular component

GBP1 GBP2 GBP3

1.87e-04151603GO:0018995
GeneOntologyCellularComponentdendritic filopodium

FMR1 MAP2

3.46e-0441602GO:1902737
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

ING5 KAT6B

1.19e-0371602GO:0070776
MousePhenoabnormal bone marrow cell morphology/development

DLGAP2 ZNF493 SPI1 PDGFB MATK ING5 ZNF208 PICALM RGS18 DST PTPRC KMT2A PRKDC DIAPH3 HERC1 ZNF107 ARHGAP21 ABCC10

3.15e-0570612018MP:0002398
MousePhenoabnormal hematopoietic stem cell physiology

SPI1 PAK2 KMT2A PRKDC ARHGAP21

3.98e-05451205MP:0010763
MousePhenoabnormal proerythroblast morphology

SPI1 PDGFB ING5 PICALM KMT2A DIAPH3

4.06e-05741206MP:0002416
MousePhenoabnormal hematopoietic stem cell morphology

SPI1 MATK ING5 PICALM KMT2A PRKDC ARHGAP21

4.96e-051121207MP:0004808
MousePhenoincreased susceptibility to parasitic infection induced morbidity/mortality

GBP1 GBP2 GBP3

9.68e-05111203MP:0010750
DomainZnf_C2H2-like

ZNF438 ZNF93 AKAP8 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF804B ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

2.00e-0779615623IPR015880
DomainZnf_C2H2

ZNF438 ZNF93 AKAP8 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF804B ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

2.44e-0780515623IPR007087
DomainZnF_C2H2

ZNF438 ZNF93 AKAP8 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF804B ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

2.60e-0780815623SM00355
Domainzf-C2H2

ZNF438 ZNF93 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

3.30e-0769315621PF00096
Domainzf-C2H2_6

ZNF93 ZNF493 ZNF273 ZNF429 ZNF208 ZNF236 PRDM2 ZNF676 ZNF728 ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

4.03e-0731415614PF13912
DomainZINC_FINGER_C2H2_2

ZNF438 ZNF93 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF804B ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

5.11e-0777515622PS50157
DomainZINC_FINGER_C2H2_1

ZNF438 ZNF93 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF804B ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

5.33e-0777715622PS00028
Domain-

ZNF438 ZNF93 ZNF493 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

1.00e-06679156203.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF438 ZNF93 ZNF493 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 PRDM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

1.40e-0669415620IPR013087
DomainKRAB

ZNF93 ZNF273 ZNF429 ZNF208 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782

1.00e-0535815613PS50805
DomainKRAB

ZNF93 ZNF273 ZNF429 ZNF208 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782

1.38e-0536915613SM00349
DomainKRAB

ZNF93 ZNF273 ZNF429 ZNF208 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782

1.42e-0537015613IPR001909
DomainGBP_C

GBP1 GBP2 GBP3

6.57e-05101563PF02841
DomainP-loop_NTPase

PNKP MYH11 GBP1 GBP2 GAL3ST4 GBP3 AK9 XRCC2 ATAD3B GTPBP8 GIMAP8 ATAD3C MTIF2 NAV1 MYH15 RAB21 DDX39A DDX39B ABCC10

8.66e-0584815619IPR027417
DomainG_GB1_RHD3_dom

GBP1 GBP2 GBP3

8.98e-05111563IPR030386
DomainGuanylate-bd_N

GBP1 GBP2 GBP3

8.98e-05111563IPR015894
DomainGuanylate-bd_C

GBP1 GBP2 GBP3

8.98e-05111563IPR003191
DomainGBP

GBP1 GBP2 GBP3

8.98e-05111563PF02263
DomainG_GB1_RHD3

GBP1 GBP2 GBP3

8.98e-05111563PS51715
DomainDUF3523

ATAD3B ATAD3C

2.07e-0431562IPR021911
DomainDUF3523

ATAD3B ATAD3C

2.07e-0431562PF12037
DomainKRAB

ZNF93 ZNF273 ZNF429 ZNF208 ZNF708 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782

2.15e-0435815611PF01352
DomainSET

PRDM2 SETD2 EHMT1 KMT2A

3.73e-04411564PF00856
DomainPHD

INTS12 MTF2 ING5 KMT2A KAT6B

4.11e-04751565PF00628
Domain-

PNKP GBP1 GBP2 GBP3 AK9 XRCC2 ATAD3B GTPBP8 GIMAP8 ATAD3C MTIF2 NAV1 RAB21 DDX39A DDX39B ABCC10

5.20e-04746156163.40.50.300
DomainZnf_PHD-finger

INTS12 MTF2 ING5 KMT2A KAT6B

5.22e-04791565IPR019787
DomainSET

PRDM2 SETD2 EHMT1 KMT2A

5.82e-04461564SM00317
DomainSET_dom

PRDM2 SETD2 EHMT1 KMT2A

8.00e-04501564IPR001214
DomainSET

PRDM2 SETD2 EHMT1 KMT2A

8.00e-04501564PS50280
DomainPHD

INTS12 MTF2 ING5 KMT2A KAT6B

9.00e-04891565SM00249
DomainZnf_PHD

INTS12 MTF2 ING5 KMT2A KAT6B

9.95e-04911565IPR001965
DomainZF_PHD_2

INTS12 MTF2 ING5 KMT2A KAT6B

1.21e-03951565PS50016
DomainZF_PHD_1

INTS12 MTF2 ING5 KMT2A KAT6B

1.26e-03961565PS01359
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYH11 INTS12 ANKRD30B STOX1 SSRP1 LCP1 NCAPH PTGFR PSME3IP1 NEK2 ATAD3B DST ATAD3C KIAA0825 SLC27A1 SCN9A PLXNA4 KMT2A PRPF19 MYH15 UGGT2 EIF3A PRKDC DIAPH3 RAB21 DDX39A DDX39B ARHGAP21

1.08e-1014421602835575683
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF93 ZNF493 ZNF429 ZNF208 ZNF506 ZNF107

3.75e-0929160614563677
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF93 ZNF493 ZNF429 ZNF208 ZNF107

5.60e-0915160515885501
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF93 ZNF493 ZNF273 ZNF208 ZNF708 ZNF728 EHMT1 ZNF737 ZNF107 HBE1

1.32e-081811601037372979
Pubmed

GTPase properties of the interferon-induced human guanylate-binding protein 2.

GBP1 GBP2 GBP3

9.56e-08316038706832
Pubmed

Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.

GBP1 GBP2 GBP3

9.56e-083160332620042
Pubmed

[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].

GBP1 GBP2 GBP3

9.56e-083160329089068
Pubmed

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

GBP1 GBP2 GBP3

9.56e-08316031715024
Pubmed

Two families of GTPases dominate the complex cellular response to IFN-gamma.

GBP1 GBP2 GBP3

9.56e-08316039862701
Pubmed

The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.

GBP1 GBP2 GBP3

9.56e-083160311726669
Pubmed

GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

GBP1 GBP2 GBP3

9.56e-083160338636926
Pubmed

Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.

GBP1 GBP2 GBP3

9.56e-083160315717119
Pubmed

Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.

GBP1 GBP2 GBP3

9.56e-083160335383115
Pubmed

Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.

GBP1 GBP2 GBP3

9.56e-083160320950129
Pubmed

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

GBP1 GBP2 GBP3

9.56e-083160330062052
Pubmed

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

GBP1 GBP2 GBP3

9.56e-083160326416908
Pubmed

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

GBP1 GBP2 GBP3

9.56e-083160332354743
Pubmed

Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.

GBP1 GBP2 GBP3

9.56e-083160323248289
Pubmed

Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.

GBP1 GBP2 GBP3

9.56e-083160336639389
Pubmed

The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.

GBP1 GBP2 GBP3

9.56e-083160316914101
Pubmed

The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

GBP1 GBP2 GBP3

9.56e-083160322730319
Pubmed

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

GBP1 GBP2 GBP3 AIM2

1.39e-0711160427693356
Pubmed

The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.

CALR GBP1 GBP2 LCP1 VIRMA NAMPT PTPRC PRPF19 EIF3A DDX39B

1.80e-072391601026641092
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

TPP2 DLGAP2 MYH11 FMR1 MAP2 WDR37 VIRMA ATAD3B DST NF1 ATAD3C SLC27A1 PLXNA4 NAV1 KMT2A PRPF19 TANC1 EIF3A FH PPP6R2 DDX39B ARHGAP21 NCK2

1.86e-0714311602337142655
Pubmed

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

GBP1 GBP2 GBP3 AIM2

2.07e-0712160435906252
Pubmed

cDNA for the beta 1 subunit of guanyl nucleotide-binding regulatory proteins from mouse adrenal glands.

GBP1 GBP2 GBP3

3.81e-07416038917111
Pubmed

The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.

GBP1 GBP2 GBP3

3.81e-074160339337476
Pubmed

Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.

GBP1 GBP2 GBP3

3.81e-07416037823961
Pubmed

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.

GBP1 GBP2 GBP3

3.81e-074160336609599
Pubmed

Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.

GBP1 GBP2 GBP3

3.81e-074160310386861
Pubmed

Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.

GBP1 GBP2 GBP3

3.81e-074160338404575
Pubmed

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

GBP1 GBP2 GBP3 AIM2

5.66e-0715160425774716
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

AKAP8 EML4 MATK ZNF217 SSRP1 VIRMA PRDM2 SETD2 NF1 PTPRC NAF1 KMT2A PLA2G4A UTP20 PRKDC KAT6B

6.45e-077741601615302935
Pubmed

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

ZNF93 ZNF208 ZNF737 ZNF107

7.52e-071616048467795
Pubmed

Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.

GBP1 GBP2 GBP3

9.49e-07516039858320
Pubmed

TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.

GBP1 GBP2 GBP3

9.49e-075160330858199
Pubmed

Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.

GBP1 GBP2 GBP3

9.49e-075160312396730
Pubmed

Unique features of different members of the human guanylate-binding protein family.

GBP1 GBP2 GBP3

9.49e-075160317266443
Pubmed

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

GBP1 GBP2 GBP3

9.49e-075160321151871
Pubmed

Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.

GBP1 GBP2 GBP3

9.49e-075160331964735
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

TPP2 USP34 MAP2 CALR GBP1 GBP2 TSN SSRP1 RRM1 NCAPH NAMPT DNAAF10 NAF1 PAK2 PLA2G4A PRPF19 EIF3A PRKDC HERC1 FH DDX39A DDX39B

9.76e-0714551602222863883
Pubmed

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

GBP1 GBP2 GBP3 AIM2

9.80e-0717160425774715
Pubmed

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

SPI1 GBP1 GBP2 GBP3

1.26e-0618160427001747
Pubmed

Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

GBP1 GBP2 GBP3

1.89e-066160321757726
Pubmed

Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.

GBP1 GBP2 GBP3

1.89e-066160317293456
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

FMR1 EML4 FREM2 IBTK NAMPT DST LLGL1 MTIF2 DDHD1 KMT2A UGGT2 TANC1 PPP6R2 ARHGAP21

2.08e-066501601438777146
Pubmed

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.

GBP1 GBP2 GBP3 AIM2

2.43e-0621160419158679
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

AKAP8 ING5 ZNF217 ATAD3B ATAD3C PRPF19 KAT6B

3.23e-06135160731077711
Pubmed

TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.

GBP1 GBP2 GBP3

3.30e-067160330587103
Pubmed

The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.

GBP1 GBP2 GBP3

3.30e-067160321502320
Pubmed

The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase.

GBP1 GBP2 GBP3

3.30e-067160320505078
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

MYH11 CALR TPTE2 VIRMA ATAD3B KMT2A EIF3A PRKDC

4.73e-06202160824639526
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

FMR1 EML4 RTF2 LCP1 WDR37 PICALM ATAD3B PTPRC ATAD3C NAF1 EIF3A DDX39A DDX39B ATG16L2

4.95e-067011601430196744
Pubmed

In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.

GBP1 GBP2 GBP3

5.26e-068160316689661
Pubmed

New nomenclature for chromatin-modifying enzymes.

PRDM2 SETD2 EHMT1 KMT2A KAT6B

6.68e-0657160518022353
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NCAPH PICALM PSME3IP1 IBTK SETD2 NAMPT DST NAF1 PAK2 KMT2A PRPF19 EIF3A PRKDC PRMT7 PPP6R2 ARHGAP21

7.13e-069341601633916271
Pubmed

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

GBP1 GBP2 GBP3

7.87e-069160324739961
Pubmed

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.

GBP1 GBP2 GBP3

7.87e-069160333479228
Pubmed

Defining the membrane proteome of NK cells.

SLC37A1 PNKP FMR1 AKAP8 CALR EML4 NCAPH PICALM NF1 PTPRC PARP16 GLE1 SLC27A1 PRPF19 CHID1 EIF3A PRKDC DDX39A

7.92e-0611681601819946888
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF493 ZNF208 ZNF107

1.12e-0510160318588511
Pubmed

Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.

GBP1 GBP2 GBP3

1.12e-0510160328334111
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

FMR1 EML4 RRM1 PSME3IP1 NAMPT DST LLGL1 TANC1 PRMT7 DDX39B ARHGAP21

1.30e-054721601138943005
Pubmed

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

GBP1 GBP2 GBP3

1.53e-0511160324715728
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF493 ZNF208 ZNF107

1.53e-0511160315469996
Pubmed

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.

GBP1 LCP1 PTPRC

1.53e-0511160324337748
Pubmed

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

GBP1 GBP2 GBP3

1.53e-0511160318025219
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

VWA3A CNBD1 TTLL3 INTS12 CYBC1 WDR37 NCAPH VIRMA CASP12 ATAD3B NF1 ATAD3C GLE1 DDHD1 HERC1 PRMT7 RAB21 ATG16L2

1.80e-0512421601830973865
Pubmed

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

GBP1 GBP2 GBP3

2.04e-0512160329459437
Pubmed

Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49.

DDX39A DDX39B

2.10e-052160216949217
Pubmed

Dimerization and its role in GMP formation by human guanylate binding proteins.

GBP1 GBP2

2.10e-052160220923658
Pubmed

A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.

PICALM KMT2A

2.10e-052160212461747
Pubmed

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.

SETD2 KMT2A

2.10e-052160229249820
Pubmed

Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.

DDX39A DDX39B

2.10e-052160220610707
Pubmed

Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.

DDX39A DDX39B

2.10e-052160238225262
Pubmed

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.

SETD2 KMT2A

2.10e-052160229777171
Pubmed

Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12).

SETD2 NF1

2.10e-052160228498454
Pubmed

Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.

GBP1 GBP2

2.10e-052160223086406
Pubmed

Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine.

GBP1 GBP2

2.10e-052160220483731
Pubmed

Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing.

DDX39A DDX39B

2.10e-052160238801080
Pubmed

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription.

SSRP1 SETD2

2.10e-052160223325844
Pubmed

Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.

DDX39A DDX39B

2.10e-052160238377942
Pubmed

The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1.

GBP1 GBP3

2.10e-05216027518790
Pubmed

Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.

GBP1 GBP2

2.10e-052160236460216
Pubmed

The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.

DDX39A DDX39B

2.10e-052160220573985
Pubmed

Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.

PTPRC PRKDC

2.10e-052160221135032
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

TPP2 AKAP8 RTF2 SSRP1 NCAPH VIRMA NAMPT EHMT1 UTP20 PRKDC RAB21 DDX39A DDX39B

2.48e-057041601329955894
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF493 ZNF208 ZNF107

2.64e-0513160319850934
Pubmed

UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.

PNKP SSRP1 PRKDC

3.35e-0514160334111398
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

USP34 INTS12 EML4 TSN BROX SETD2 FAT1 NF1 MROH1 UGGT2 PRKDC HERC1 FH RAB21 DDX39B ABCC10

3.37e-0510611601633845483
Pubmed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

MAP2 WDR37 HERC1 ATG16L2

3.46e-0540160429078390
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

USP34 AKAP8 ZDBF2 IBTK SETD2 GLE1 DDHD1 NAV1 UGGT2 DCLRE1A TANC1 RAB21 NCK2

3.75e-057331601334672954
Pubmed

Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.

GBP1 GBP2 GBP3

4.17e-0515160317114464
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

INTS12 AKAP8 MAP2 MATK SSRP1 VIRMA C6orf132 DST NF1 NAV1 KMT2A TANC1 RAB21 ARHGAP21

4.80e-058611601436931259
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

ZNF93 AK9 SSRP1 RRM1 ZNF236 NCAPH ATAD3B GTPBP8 ZNF506 ZNF107

4.91e-054511601036168627
Pubmed

Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.

FMR1 CAPN6 PPP6R2

5.12e-0516160314743444
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TPP2 USP34 FMR1 CALR LCP1 VIRMA DST NF1 KMT2A UTP20 PRKDC FH

5.36e-056531601222586326
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

ZDBF2 PICALM IBTK DST TANC1 EIF3A ARHGAP21

5.49e-05209160736779422
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

USP34 FMR1 AKAP8 ING5 REV3L SSRP1 WDR37 SETD2 ATAD3B FAT1 CCNB3 MTIF2 NAF1 EHMT1 TANC1 KAT6B

6.13e-0511161601631753913
Pubmed

Utility of Peripherin Versus MAP-2 and Calretinin in the Evaluation of Hirschsprung Disease.

MAP2 CALR

6.29e-053160226469323
Pubmed

Identification of functional cooperative mutations of SETD2 in human acute leukemia.

SETD2 KMT2A

6.29e-053160224509477
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF93 ZNF493 ZNF429 ZNF208 ZNF708 ZNF676 ZNF728 ZNF737 ZNF431 ZNF723

1.96e-1112216010chr19p12
Cytoband19p12

ZNF93 ZNF493 ZNF208 ZNF708 ZNF676 ZNF728 ZNF737 ZNF431 ZNF723

3.35e-1190160919p12
Cytoband1p22.2

GBP1 GBP2 GBP3

1.28e-042816031p22.2
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF438 ZNF93 ZNF493 TSHZ2 ZNF273 ZNF429 ZNF208 ZNF217 ZNF236 ZFPM2 ZNF708 ZNF23 ZNF676 ZNF37A ZNF728 ZNF737 ZNF506 ZNF431 ZNF782 ZNF107

4.05e-097181042028
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

PRDM2 SETD2 EHMT1 KMT2A

4.20e-05341044487
GeneFamilyPHD finger proteins

INTS12 MTF2 ING5 KMT2A KAT6B

1.71e-0490104588
GeneFamilyWD repeat domain containing

EML4 WDR37 LLGL1 DNAAF10 PRPF19 HERC1 ATG16L2

7.97e-042621047362
CoexpressionMARTINEZ_RB1_TARGETS_UP

TPP2 USP34 INTS12 MAP2 MTF2 CAPN6 GBP1 GBP2 GBP3 RRM1 LCP1 PTGFR FABP1 EIF3A SUCO SPESP1

1.31e-0574116016MM1037
CoexpressionKONDO_COLON_CANCER_HCP_WITH_H3K27ME1

TPP2 LGI2 PLA2G4A CCDC181

1.80e-05261604M13354
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

USP34 MTF2 REV3L WDR37 PICALM IBTK SETD2 FAT1 NAMPT DST MTIF2 UTP20 EIF3A KAT6B RAB21 SUCO NPAT

2.04e-0585616017M4500
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_UP

TPP2 USP34 INTS12 MAP2 CAPN6 GBP1 GBP2 GBP3 RRM1 LCP1 PTGFR VIRMA FABP1 EIF3A SUCO

2.26e-0568916015MM1041
CoexpressionTOYOTA_TARGETS_OF_MIR34B_AND_MIR34C

ZNF493 ZNF273 XRCC2 NEK2 SETD2 HASPIN NAV1 PRPF19 UGGT2 ZNF107 PPP6R2 DDX39B

2.41e-0545416012M19927
CoexpressionGSE360_L_DONOVANI_VS_M_TUBERCULOSIS_MAC_DN

GBP1 GBP2 CPB1 SCN9A KMT2A AIM2 ABCC10 NCK2

3.19e-051991608M5242
CoexpressionGSE22443_IL2_VS_IL12_TREATED_ACT_CD8_TCELL_DN

SPI1 PDGFB TSN RRM1 LCP1 NCAPH DCLRE1A FH

3.31e-052001608M8218
CoexpressionGSE29164_CD8_TCELL_VS_CD8_TCELL_AND_IL12_TREATED_MELANOMA_DAY3_UP

INTS12 MTF2 TSN USP46 MROH1 PAK2 DDX39A NPAT

3.31e-052001608M8491
CoexpressionMIKKELSEN_NPC_LCP_WITH_H3K4ME3

GBP1 GBP2 GAL3ST4 GBP3 CASP12

3.89e-05621605MM865
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

USP34 FMR1 EML4 MATK CYBC1 GBP2 GBP3 ZNF217 REV3L LCP1 PICALM STN1 PRDM2 SETD2 PTPRC GIMAP8 ERAP2 PAK2 KMT2A HERC1 KAT6B RAB21 NPAT

3.93e-05149216023M40023
CoexpressionMONNIER_POSTRADIATION_TUMOR_ESCAPE_DN

ZNF438 PNKP ZNF493 GBP1 GBP2 GBP3 ZNF208 CASP12 CHID1 ZNF107 NCK2

3.97e-0540316011MM1029
CoexpressionPUJANA_ATM_PCC_NETWORK

TPP2 USP34 DLGAP2 SPI1 MTF2 ZNF273 XRCC2 RRM1 LCP1 PRDM2 PTPRC ZNF37A GLE1 PAK2 PRPF19 MYH15 PRKDC DDX39A AIM2 DDX39B ABCC10 NPAT

4.16e-05139416022M9585
CoexpressionMARTINEZ_RB1_TARGETS_UP

TPP2 USP34 INTS12 MAP2 MTF2 CAPN6 GBP2 RRM1 LCP1 PTGFR FABP1 EIF3A SUCO SPESP1

9.05e-0569016014M12224
CoexpressionMARTINEZ_TP53_TARGETS_UP

TPP2 USP34 INTS12 MAP2 CAPN6 GBP1 GBP2 GBP3 RRM1 LCP1 PTGFR FABP1 EIF3A SUCO

9.62e-0569416014MM1039
CoexpressionJOHNSTONE_PARVB_TARGETS_3_DN

FMR1 MTF2 ZNF273 RRM1 NCAPH BROX NEK2 SETD2 ZNF23 ERAP2 C8orf76 ZNF506 PRKDC DIAPH3 FH SUCO

9.80e-0587716016M2241
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

ZNF217 REV3L WDR37 FAT1 DST MTIF2 KAT6B SUCO NPAT

9.97e-053001609M8702
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_UP

TPP2 USP34 INTS12 MAP2 CAPN6 GBP2 RRM1 LCP1 PTGFR VIRMA FABP1 EIF3A SUCO

1.23e-0462316013M15896
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_200

MAP2 TSHZ2 MUC16 ZFPM2 FREM2 HMCN1 PLXNA4 PLA2G4A AIM2

1.14e-061431569gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_200
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_1000

MYH11 MAP2 MUC16 REV3L ZFPM2 HMCN1 PLA2G4A

7.45e-06971567gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k2_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_100

MAP2 MUC16 PLA2G4A AIM2

9.97e-06191564gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k2_100
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_200

TSHZ2 MUC16 HMCN1 AIM2

1.52e-05211564gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k4_200
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

MYH11 MAP2 MUC16 GBP1 GBP2 REV3L WDR37 F8 PCDH20 ZFPM2 ZNF23 DST HMCN1 PLXNA4 PLA2G4A KAT6B ARHGAP21

7.46e-0579115617gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_1000

MYH11 MAP2 REV3L ZFPM2 ZNF23 PLXNA4 PLA2G4A KAT6B

8.63e-051911568gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_500

MYH11 MAP2 MUC16 ZFPM2 FREM2 AIM2

9.64e-051001566gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k2_500
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_200

MAP2 MUC16 FREM2 AIM2

9.72e-05331564gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k3_200
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_500

MYH11 MAP2 TSHZ2 MUC16 GBP2 ZFPM2 FREM2 HMCN1 PLXNA4 PLA2G4A AIM2

9.95e-0537215611gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_500
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_500

MYH11 MAP2 CAPN6 MUC16 GBP2 ZFPM2 FREM2 HMCN1 PLXNA4 PLA2G4A AIM2

1.34e-0438515611gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_500
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_200

MAP2 MUC16 ZFPM2 HMCN1 PLXNA4 PLA2G4A AIM2

1.70e-041581567gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_200
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BEST1 SPI1 GBP1 GBP2 LCP1 NAMPT RGS18 PTPRC PRKDC ATG16L2

2.52e-0919616010fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BEST1 SPI1 GBP1 GBP2 LCP1 NAMPT RGS18 PTPRC PRKDC ATG16L2

2.52e-0919616010526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 EML4 PRDM2 NF1 PTPRC DDHD1 KMT2A HERC1 SUCO

2.81e-081881609ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BEST1 SPI1 GBP1 GBP2 LCP1 RGS18 PTPRC PRKDC ATG16L2

4.20e-0819716093cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 TSHZ2 XRCC2 NCAPH ZFPM2 NEK2 MYH15 DIAPH3

2.02e-071711608b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP2 TSHZ2 XRCC2 NCAPH ZFPM2 NEK2 MYH15 DIAPH3

2.02e-071711608b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 TSHZ2 EML4 ZDBF2 PTPRC KMT2A HERC1 DDX39B

5.92e-07197160857ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellCiliated_cells-A-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

VWA3A MUC16 STOX1 GRAMD2B ELAPOR1 VWA3B CCDC181

2.79e-0617016073d3a03979014df3a05c49be18010c6b94d786707
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP2 MATK PCDH20 FABP1 PTPRC CCNB3 SUCO

2.79e-06170160717bd7fd25a2657cb536ad47e294332920f759e95
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPI1 PDGFB MATK GBP2 LCP1 PTPRC GRAMD2B

3.51e-06176160798176bf3c961d5262593e2d5d002836adb010e13
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH11 TTLL3 MAP2 ZDBF2 ZNF23 NF1 ELAPOR1

3.64e-0617716078abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

USP34 TSHZ2 EML4 PTPRC DDHD1 HERC1 DDX39B

4.22e-061811607f2315414e714ac86211546a935660c4be6e85f1b
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

GBP1 GBP2 GBP3 ZNF217 SETD2 DST ERAP2

4.53e-0618316078f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellURO-Lymphocyte-T_NK-T_NK_proliferative|URO / Disease, Lineage and Cell Type

XRCC2 RRM1 NCAPH NEK2 HASPIN DIAPH3 IL26

4.87e-0618516070ae9c646679c69a553eda670aef0e0495feb0286
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

DLGAP2 MUC16 CPB1 ZFPM2 KLHL31 FAT1 PTPRQ

4.87e-06185160723579988036fc1925992c31919750f9b3fe9f790
ToppCellPBMC-Mild-cDC_12|Mild / Compartment, Disease Groups and Clusters

XRCC2 RRM1 LCP1 NCAPH UTP20 TANC1 PRKDC

5.60e-061891607946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MATK GBP2 LCP1 PTPRC GRAMD2B ELAPOR1 IL26

5.60e-06189160778dcda09109a5cfb04ba069f16ec80987b3ad432
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPI1 PDGFB MATK GBP2 LCP1 PTPRC GRAMD2B

5.80e-061901607e0b363f772817cfc6ab425430805c1cddcba23f0
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

VWA3A FRMPD2 MUC16 STOX1 C6orf132 VWA3B CCDC181

6.00e-0619116079f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWA3A FRMPD2 MUC16 STOX1 C6orf132 VWA3B CCDC181

6.00e-0619116075129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BEST1 LCP1 NAMPT RGS18 PTPRC PRKDC ATG16L2

6.00e-06191160747156e5f1d790707f42f6283104a44b33af613e5
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

VWA3A FRMPD2 MUC16 STOX1 C6orf132 VWA3B CCDC181

6.00e-061911607df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCellControl-Epithelial|Control / Disease group,lineage and cell class (2021.01.30)

VWA3A FRMPD2 MUC16 STOX1 C6orf132 VWA3B CCDC181

6.00e-061911607b78547dae8328244a47c83346447bdd787efbcae
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWA3A FRMPD2 MUC16 STOX1 C6orf132 VWA3B CCDC181

6.00e-061911607c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCellSevere_COVID-19-Myeloid-proliferating_Myeloid_cells|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.43e-0619316070d85025690c9cd545cba30abc38acbdd6a39b153
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MYH11 XRCC2 RRM1 NCAPH KIAA1210 PLXNA4 DIAPH3

6.43e-061931607bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.65e-0619416072360b5f995b360419de41612368cab9fb61781a1
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.65e-061941607903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCellMonocytes-HP_01|World / lung cells shred on cell class, cell subclass, sample id

SPI1 GBP1 GBP2 LCP1 NAMPT RGS18 PTPRC

6.65e-061941607fa6a2794baa6be6298f415330ff51b26a5402571
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.65e-061941607cb39850e9577015b6b9834e98c36b412bae7d462
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.65e-061941607408597c9aa302a44b112c1d612c21fbb0227a82a
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.65e-061941607193cc20fefbd795a4ad59e401a95af47d30603e7
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

XRCC2 RRM1 NCAPH NEK2 DST HASPIN DIAPH3

6.65e-06194160758406502a8cbcc3037f79a1b6a683df408297ae5
ToppCellsevere-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SPI1 ZNF429 GBP1 GBP2 GBP3 NAMPT AIM2

7.35e-061971607c8a90d82170cf20e14aebecddcf7cc0ca56cda87
ToppCellhematopoetic_progenitors-CD34+_MPP|hematopoetic_progenitors / Lineage and Cell class

SPI1 CALR SSRP1 RRM1 LCP1 FH DDX39A

7.85e-061991607ec127c5a374a005ecf1377fb9bd245a7244505bf
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BEST1 SPI1 GBP2 LCP1 NAMPT PTPRC ATG16L2

7.85e-0619916079da8b48ec1c1c105fcbab6ae8f08166e7d5e8a35
ToppCellLPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC37A1 XRCC2 NEK2 RGS18 PTPRQ DIAPH3 ARHGAP21

8.11e-062001607e4be88bcef2738915f711b32c95e9c613e7edf96
ToppCellSepsis-ICU-NoSEP-Lymphocyte-T/NK-T/NK_proliferative|ICU-NoSEP / Disease, condition lineage and cell class

XRCC2 SSRP1 RRM1 NCAPH NEK2 DIAPH3 DDX39A

8.11e-062001607f70cc9198339eab7fbc68f5d9b75dfb28c9afc89
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 GBP1 PRDM2 SETD2 PTPRC KMT2A EIF3A

8.11e-06200160712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellVE|World / Condition, Cell_class and T cell subcluster

CALR GBP1 LCP1 PTPRC PAK2 KMT2A NCK2

8.11e-0620016078ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellICU-NoSEP-Lymphocyte-T_NK-T_NK_proliferative|ICU-NoSEP / Disease, Lineage and Cell Type

XRCC2 SSRP1 RRM1 NCAPH NEK2 DIAPH3 DDX39A

8.11e-062001607d86119766b9c4f1570cd8045313345f9be46d431
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

MYH11 TSHZ2 ZFPM2 FAT1 DST PLXNA4 DCLK3

8.11e-06200160702cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCellLPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MATK LCP1 NCAPH RGS18 DIAPH3 IL26

1.79e-051511606b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A MYH11 HMCN1 PTPRQ MYH15 SPESP1

2.48e-051601606c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A MYH11 HMCN1 PTPRQ MYH15 SPESP1

2.48e-05160160625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BEST1 STN1 KLHL31 RGS18 PTPRC DIAPH3

2.66e-05162160693bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

USP34 EML4 ZNF708 PTPRC DDHD1 ZNF506

2.66e-051621606b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALR GBP2 LCP1 PTPRC GIMAP8 PAK2

3.16e-051671606d72b08b3cbc34b30a11dcf512e472b64d1606ec1
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALR GBP2 LCP1 PTPRC GIMAP8 PAK2

3.16e-05167160622f7384ff2044898d7b0b01cb9d9a3cbaa93a9a3
ToppCellMonocytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

SPI1 LCP1 RGS18 PTPRC GIMAP8 ATG16L2

3.49e-0517016064e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T|Lung / Manually curated celltypes from each tissue

AMER3 RRM1 NCAPH NEK2 HASPIN DIAPH3

4.24e-051761606a40dfd8c4ba16757ff929b2f03a0628acf334de4
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

WDR37 DST ZNF37A KMT2A HERC1 KAT6B

4.37e-051771606e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPI1 GBP2 LCP1 ZNF23 RGS18 PTPRC

4.51e-051781606aa9f68a66e292f331faef881bbd0d028f0f2b0c5
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP2 MATK PCDH20 FABP1 PTPRC SUCO

4.51e-05178160609a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

TSHZ2 GBP1 GBP2 GBP3 ERAP2 AIM2

4.66e-051791606af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCelldroplet-Liver-LIVER_NPC-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ2 F8 RGS18 PLXNA4 NAV1 NCK2

4.66e-051791606025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MATK CYBC1 CPB1 ERAP2 DDHD1 ELAPOR1

4.66e-051791606db76edd368eeca05a2a5d407c3eb2f535ade0ce3
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EML4 MATK GBP2 ATAD3B PTPRC GRAMD2B

4.80e-051801606ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPI1 NAMPT RGS18 PTPRC ATG16L2

4.84e-051101605854f21560ce7cb5e1923403b6d04df3d804431e2
ToppCellwk_20-22-Hematologic-Meg-ery-Platelet|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BROX ZNF23 RGS18 ZNF431 DCLRE1A HERC1

4.95e-051811606724efbc200e8388829bc7d81830c2689a95fa838
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD30B FREM2 NAF1 ZNF804B PTPRQ PLA2G4A

4.95e-0518116063e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCellPCW_07-8.5-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC2_(21)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MATK GBP2 LCP1 PTPRC GRAMD2B IL26

4.95e-0518116061fa882ee66e6f835acf3f293fd24dc7f8b1eff99
ToppCellmild_COVID-19_(asymptomatic)-T/NK_proliferative|World / disease group, cell group and cell class (v2)

XRCC2 RRM1 NCAPH NEK2 HASPIN DIAPH3

5.11e-0518216069adf90bb2808f234d53b89ca0ae07380478204ad
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPI1 GBP1 GBP2 LCP1 PTPRC AIM2

5.11e-051821606dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|367C / Donor, Lineage, Cell class and subclass (all cells)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

5.26e-051831606cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCellmild_COVID-19_(asymptomatic)-T/NK_proliferative|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

XRCC2 RRM1 NCAPH NEK2 HASPIN DIAPH3

5.26e-051831606df8568751205313d149939ea2683097e3652a60b
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|367C / Donor, Lineage, Cell class and subclass (all cells)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

5.26e-051831606b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 FAT1 HMCN1 PTPRQ SCN9A MYH15

5.43e-0518416062cbed6462fea2622871bb7e49b0df3d984239281
ToppCellNS-moderate-d_07-13-Myeloid-Neutrophil|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPI1 GBP1 LCP1 NAMPT RGS18 PTPRC

5.43e-0518416064c7d05f1a4556b13cedbaaf88d67ac32d09b109b
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LCP1 NAMPT DST DDHD1 EIF3A AIM2

5.43e-051841606fe9ea4d0e0be820e95eaf9bb42a5560d0e177574
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BEST1 SPI1 LCP1 NAMPT RGS18 PTPRC

5.43e-051841606d7f348aa8901d819c68da20728b9238407bcdca9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 FAT1 HMCN1 PTPRQ SCN9A MYH15

5.43e-0518416062b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC37A1 LCP1 PTPRC GRAMD2B ELAPOR1 IL26

5.43e-0518416063e9d75af578297950e469f23fb2d28393a2feef8
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 FAT1 HMCN1 PTPRQ SCN9A MYH15

5.43e-051841606ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ2 F8 CASP12 GIMAP8 NAV1 TANC1

5.59e-051851606bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellCOPD-Epithelial-Mesothelial|COPD / Disease state, Lineage and Cell class

MUC16 CPB1 ZFPM2 KLHL31 FAT1 PTPRQ

6.29e-05189160679bb2593ad5d17f94b17972884241f03a0f43770
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPI1 PDGFB MATK GBP2 LCP1 PTPRC

6.29e-051891606440c422369de1c49112d18cf8c506a2a3a81f6ba
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ZNF93 MYH11 XRCC2 RRM1 NCAPH DIAPH3

6.48e-051901606e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

VWA3A FRMPD2 MUC16 STOX1 VWA3B CCDC181

6.67e-0519116067b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

6.67e-05191160646c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWA3A FRMPD2 MUC16 STOX1 VWA3B CCDC181

6.67e-051911606fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellControl-Epithelial-Ciliated_cells|Control / Condition, Lineage and Cell class

VWA3A FRMPD2 WFDC6 MUC16 VWA3B CCDC181

6.67e-051911606ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWA3A FRMPD2 MUC16 STOX1 VWA3B CCDC181

6.67e-051911606c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

6.67e-051911606995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

6.67e-051911606a37f20172b85566b9039254a89680e37fd503fd5
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class (2021.01.30)

VWA3A FRMPD2 MUC16 STOX1 VWA3B CCDC181

6.67e-051911606cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

6.67e-0519116062a8e6d560907e71e9f6e190ca0667da804e25641
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T|bone_marrow / Manually curated celltypes from each tissue

RRM1 NCAPH NEK2 DIAPH3 DDX39A IL26

6.67e-051911606210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

VWA3A FRMPD2 MUC16 STOX1 VWA3B CCDC181

6.67e-051911606b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

VWA3A FRMPD2 WFDC6 STOX1 VWA3B CCDC181

6.67e-0519116062d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic-lymphocyte-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RRM1 NCAPH NEK2 DIAPH3 DDX39A IL26

6.67e-05191160656b45259dfc38bd5ea43b0e3adf47e7e2c043a5d
ToppCellControl-Epithelial|Control / Condition, Lineage and Cell class

VWA3A FRMPD2 WFDC6 MUC16 VWA3B CCDC181

6.67e-0519116066228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCellNS-moderate-d_16-33-Myeloid-Neutrophil|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

BEST1 SPI1 LCP1 NAMPT RGS18 PTPRC

6.87e-051921606545c3990cbe3c04bfd95a0ab7499d2c4af509be1
ToppCellFetal_29-31_weeks-Immune-monocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SPI1 ZNF217 LCP1 RGS18 PTPRC ATG16L2

6.87e-0519216065417f024fcc89eaeab33f4a2c6421d1cfabd681b
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TSHZ2 EML4 PTPRC KMT2A HERC1 DDX39B

6.87e-05192160647646d7e4990be85072987f92bf18d52f8da752e
ToppCellmoderate-Myeloid-Neutrophil|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

BEST1 SPI1 LCP1 NAMPT RGS18 PTPRC

6.87e-0519216068105408400dac5dcb0ce62b558433257559c9f09
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

VWA3A TSHZ2 ZNF273 FRMPD2 STOX1 VWA3B

7.07e-051931606ea345d34440b25f65358a53dc72831998d1c3620
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MYH11 XRCC2 RRM1 NCAPH PLXNA4 DIAPH3

7.07e-051931606516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCellPBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

XRCC2 RRM1 NCAPH NEK2 HASPIN DIAPH3

7.27e-051941606f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCellP03-Endothelial-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRM1 NCAPH NEK2 HASPIN DIAPH3 DDX39A

7.27e-05194160622bcfb0f3f73608feb22c0847ab4d34f87aeede0
DiseaseLeukemia, Myelocytic, Acute

MYH11 SPI1 XRCC2 PICALM SETD2 NF1 KMT2A

3.63e-051731547C0023467
Diseasememory performance

DLGAP2 CNBD1 MYH11 TSHZ2 NXPH1 ITIH3 ZNF804B ZNF737 FH HBE1

6.13e-0540915410EFO_0004874
Diseaseneuromuscular disease (implicated_via_orthology)

ATAD3B ATAD3C

1.61e-0441542DOID:440 (implicated_via_orthology)
Diseaseviral infectious disease (implicated_via_orthology)

PTPRQ EHMT1

2.68e-0451542DOID:934 (implicated_via_orthology)
DiseaseAcute myelomonocytic leukemia

MYH11 KMT2A

2.68e-0451542C0023479
Diseaseurate measurement, bone density

DLGAP2 TSHZ2 NXPH1 GBP3 LCP1 PLXNA4 NAV1 UGGT2 VWA3B PRKDC KAT6B

4.27e-0461915411EFO_0003923, EFO_0004531
Diseaseresting heart rate, chronic obstructive pulmonary disease

ZFPM2 STN1 HERC1

5.10e-04301543EFO_0000341, EFO_0004351
DiseaseAcute Myeloid Leukemia, M1

MYH11 SPI1 PICALM NF1 KMT2A

5.14e-041251545C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

MYH11 SPI1 PICALM NF1 KMT2A

5.14e-041251545C1879321
Diseaseblood barium measurement

DLGAP2 UTP20 CCDC181

7.41e-04341543EFO_0021528
Diseasetriacylglycerol 58:10 measurement

USP46 SCN9A TANC1

7.41e-04341543EFO_0010437
Diseaseclear cell renal cell carcinoma (is_implicated_in)

PDGFB SETD2

7.42e-0481542DOID:4467 (is_implicated_in)
Diseasemyelofibrosis (is_implicated_in)

CALR KMT2A

7.42e-0481542DOID:4971 (is_implicated_in)
Diseaselate-onset Alzheimers disease

ZNF438 SPI1 IRAK1BP1 PICALM CASP12 HMCN1 NCK2

8.91e-042921547EFO_1001870
Diseasemean platelet volume

MYH11 SPI1 ING5 IRAK1BP1 ZNF217 XRCC2 LCP1 PICALM ZFPM2 SETD2 PTPRC DDHD1 DDX39B NCK2

9.49e-04102015414EFO_0004584
DiseaseThrombocytosis, Autosomal Dominant

PDGFB CALR

9.51e-0491542C3489628
DiseaseUterine leiomyoma

ING5 ZNF208 STN1 NPAT

1.34e-03911544HP_0000131
DiseaseProteinuria

MUC16 PAK2 NCK2

1.48e-03431543C0033687
Diseaseureteral obstruction (biomarker_via_orthology)

PDGFB CASP12 PAK2

1.68e-03451543DOID:5199 (biomarker_via_orthology)
Diseaseacute myeloid leukemia (implicated_via_orthology)

SPI1 KMT2A

1.73e-03121542DOID:9119 (implicated_via_orthology)
DiseaseThrombocythemia, Essential

PDGFB CALR

1.73e-03121542C0040028
Diseasefatty acid measurement, fetal genotype effect measurement, breast milk measurement

ZNF804B DIAPH3

2.03e-03131542EFO_0005110, EFO_0007959, EFO_0009092
Diseasefatty acid measurement, breast milk measurement, parental genotype effect measurement

ZNF804B DIAPH3

2.36e-03141542EFO_0005110, EFO_0005939, EFO_0009092
Diseaseepithelial cell adhesion molecule measurement

TPP2 USP34 MTIF2

2.42e-03511543EFO_0010574
Disease3-hydroxypropylmercapturic acid measurement

USP34 DLGAP2 LCP1 ZFPM2 PLXNA4 ZNF737 KMT2A

2.58e-033521547EFO_0007014
DiseasePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

SPI1 PICALM PTPRC

2.70e-03531543C1961099
Diseaseleukemia

SETD2 NF1 KMT2A

3.00e-03551543C0023418
DiseaseDyskeratosis Congenita

STN1 NAF1

3.10e-03161542C0265965
Diseasecleft lip

NXPH1 MUC16 DST KAT6B ABCC10 NCK2

3.86e-032841546EFO_0003959
DiseaseColorectal Carcinoma

TTLL3 MAP2 CALR FRMPD2 CAPN6 ZNF217 FAT1 NAMPT NF1 CCNB3

3.91e-0370215410C0009402
Diseasesyndrome (implicated_via_orthology)

ATAD3B ATAD3C

3.92e-03181542DOID:225 (implicated_via_orthology)
Diseaseparahippocampal gyrus volume measurement

PTGFR FREM2

3.92e-03181542EFO_0010318
DiseaseMyeloid Leukemia

SPI1 KMT2A

3.92e-03181542C0023470
DiseaseLeukemia, Monocytic, Chronic

SPI1 KMT2A

3.92e-03181542C0023466
DiseaseMalignant neoplasm of breast

ZNF438 AKAP8 XRCC2 PCDH20 SETD2 NF1 LLGL1 PTPRC ELAPOR1 EHMT1 PLA2G4A UTP20 KAT6B

4.25e-03107415413C0006142
DiseaseSevere Combined Immunodeficiency

PTPRC PRKDC

4.83e-03201542C0085110
Diseaseblood lead measurement

CPB1 TANC1 SPESP1

5.02e-03661543EFO_0007040

Protein segments in the cluster

PeptideGeneStartEntry
GKTFIKSSLQVSHEK

AMER3

6

Q8N944
ETLSGHKDKVTAAKF

ATG16L2

416

Q8NAA4
KATHQKEFDTLSGKL

ANKRD30B

746

Q9BXX2
AAEQFKKTSLHVAKS

AKAP8

511

O43823
AKKDVKGSYVSIHSS

DDX39B

31

Q13838
KKDIKGSYVSIHSSG

DDX39A

31

O00148
LTSGVHSTIKVIKAK

AIM2

326

O14862
QKLFTKSHSLEGSSK

DLGAP2

236

Q9P1A6
IAGSKLKEIFDKIHS

GLE1

436

Q53GS7
SLKTVSSGAKKSFEL

BEST1

501

O76090
KDTKSADQKTTLLHF

DIAPH3

871

Q9NSV4
TKAHVEKDFIAFKSS

CASP12

256

Q6UXS9
QLSLKKKSTSHGKVF

CCNB3

746

Q8WWL7
TSLTKLSLQDGHKAK

MTF2

26

Q9Y483
DKHITTLQASFLTKK

RAB21

46

Q9UL25
ALGFLHSKSKDSAEK

INTS12

16

Q96CB8
ELSSTAKSKAHFFGK

KAT6B

576

Q8WYB5
VSAKTKFKLTAHEGC

LLGL1

841

Q15334
DTVKLKINFHGSKSS

NPAT

556

Q14207
SSDKTIKSFFPHSGK

C8orf76

196

Q96K31
SVSSTGGKLIAHKKL

FAT1

3591

Q14517
STEKSAVLHKLTTGA

MUC16

6671

Q8WXI7
GTSLETFISHLEVKK

ABCC10

611

Q5T3U5
KLFSKIGGSVLESHK

PCDH20

381

Q8N6Y1
VIGTKTKSFDVHKSV

KLHL31

76

Q9H511
QKIKSATIHAASKVF

IRAK1BP1

231

Q5VVH5
TAPEALKHGKFTSKS

MATK

391

P42679
VVKTSKSSSKHRGAV

KIAA0825

306

Q8IV33
PSSVIKKKVHFSGES

NEK2

376

P51955
SVSLKASGKNKHFKV

NCK2

321

O43639
ASILATFSVTEGKKK

MTIF2

626

P46199
VKAHGKKVLTSFGDA

HBE1

61

P02100
EKKSVTSHSSGDHVK

IBTK

1211

Q9P2D0
TSHSSGDHVKKVSFK

IBTK

1216

Q9P2D0
IKDHKDFSKTLTAQS

DST

4886

Q03001
TSKKSLFGKIKSFTS

ELAPOR1

976

Q6UXG2
SFVIKLTDGKHSVEK

FREM2

1276

Q5SZK8
GHDKDFSTQTKKLST

ZFPM2

641

Q8WW38
SIKKVSSSKGSDGHT

HERC1

456

Q15751
KSTTLKLADFGLAKH

DCLK3

491

Q9C098
PTKGFASVSEKAHKS

DNAAF10

246

Q96MX6
GVTKPIFHSTKITSK

PTGFR

136

P43088
FKHTHDKTALKETLG

PDGFB

226

P01127
KIFHGLKSTDVAKTF

LCP1

76

P13796
KNHSLAFVGTKSGKL

PLXNA4

441

Q9HCM2
KKKGFSLGSTVQSHT

GBP1

61

P32455
KKNGFSLGSTVKSHT

GBP2

61

P32456
KNKGFSLGSTVKSHT

GBP3

61

Q9H0R5
GSLAKEKTQTLHKFI

F8

201

P00451
HFSTKVLGIKVETKD

MROH1

771

Q8NDA8
FLKTHKSGSSSVLSL

GAL3ST4

71

Q96RP7
YVIVLTKIDKSSKGH

GTPBP8

221

Q8N3Z3
KKGELISTSSAKFSA

HMCN1

1016

Q96RW7
KITSFKISVKHARSG

PTPRQ

226

Q9UMZ3
SSKVLTIHSAGKAEF

PARP16

91

Q8N5Y8
KSSEQILATLKGHTK

PRPF19

251

Q9UMS4
ILATLKGHTKKVTSV

PRPF19

256

Q9UMS4
HKIISIFSGTEKGSK

PAK2

51

Q13177
GTKKEDSTAKIHAVT

CCDC181

266

Q5TID7
TVQGTFSKLFGKKHT

C6orf132

6

Q5T0Z8
FSKLFGKKHTTTPST

C6orf132

11

Q5T0Z8
TTAVSADLGTHKSLK

SLC37A1

441

P57057
AHKDFKKAVGAFSVT

FMR1

146

Q06787
KAVEDIHGLFSLSKK

EIF3A

251

Q14152
GFSDKIKVINKHSTE

PRMT7

111

Q9NVM4
KKFTITSSVTGKKHT

FRMPD2

601

Q68DX3
GKKHTFVTDSAKTSK

FRMPD2

611

Q68DX3
IAKTAHKNGSTLKET

FH

471

P07954
LSLAIAKHKQSSFTK

IL26

16

Q9NPH9
LGKHVFKSKFSDQTV

GIMAP8

31

Q8ND71
FDKSTGKVVLKTFSL

CYBC1

71

Q9BQA9
KHKSDFGKFVLSSGK

CALR

41

P27797
TGKTLFAKKLALHSG

ATAD3C

181

Q5T2N8
SFLKTTGSDFSLKKE

C3orf33

241

Q6P1S2
KKHKGGSEFTDTILS

ING5

156

Q8WYH8
ASFSFHKKKIVTDVS

HASPIN

386

Q8TF76
TTAHFSSKDKLQEVK

ERAP2

901

Q6P179
TFKEKHSSKSFLEPG

KMT2A

2436

Q03164
SKSLSKPEVKHQVFS

KIAA1210

1226

Q9ULL0
EDHVASVKKSVSSKG

EML4

56

Q9HC35
LSKVKVFTKSAHGGL

DCLRE1A

666

Q6PJP8
KSIDGKDAVHSFKLS

DDHD1

331

Q8NEL9
CFHSKVFGKDTKISI

GRAMD2B

151

Q96HH9
AKVKQGHISFKVISS

CAPN6

621

Q9Y6Q1
FKSITHSTVGSKGEK

EHMT1

316

Q9H9B1
AKATVKELASLHGTK

CPB1

331

P15086
PVHTTLSKSDAKKAA

CHID1

16

Q9BWS9
KDKFISLVLKHIGTS

PPP6R2

146

O75170
AGLTSKKSKLESHSD

PRDM2

766

Q13029
FLSNKKTSTLKHLLG

PRAC1

21

Q96KF2
KSKKIHVVDSGLTFN

PLA2G4A

541

P47712
SKTLSKSEHSLFQAK

NAV1

136

Q8NEY1
AEKALGKAASHIKSI

RTF2

71

Q9BY42
TVAKKITSEYGLKHL

AK9

1426

Q5TCS8
LHLSLKTSKIKSSGE

UTP20

2091

O75691
KDTTSKAIHSIFKNA

STN1

256

Q9H668
ASSFKGKTKIFEHII

LGI2

526

Q8N0V4
ELLKSGSSKSTLKHI

NXPH1

31

P58417
SALTKSFSGKKGHVS

ITIH3

211

Q06033
KKGASFQTVASLHKE

MYH15

651

Q9Y2K3
KLLAGAVKHKSSESG

PSME3IP1

151

Q9GZU8
KDKISGFGSSVDKHL

SCN9A

1056

Q15858
IFKGLSKKTGISSSH

TANC1

871

Q9C0D5
SIASKGSKFKELVTH

SPESP1

66

Q6UW49
DLLHTVFKNGKVTKS

NAMPT

456

P43490
AGKSTFLKKHLVSAG

PNKP

376

Q96T60
KGTFQFSSKHKEALA

SPI1

196

P17947
KHFKFTITAGSKVIQ

FABP1

46

P07148
KSDHPGISITDLSKK

SSRP1

566

Q08945
SLKIAAGIFKHLKES

BROX

146

Q5VW32
TGKTLFAKKLALHSG

ATAD3B

356

Q5T9A4
NDKHLKTLSKTVFSE

CNBD1

171

Q8NA66
THNESVSALVDKFKK

NCAPH

331

Q15003
AVVASSHKGKKDTSI

MYH11

196

P35749
GKTFSFKSVLTVHQK

ZNF37A

361

P17032
HLASLEGKKIKDSTA

PICALM

281

Q13492
HTGGTIKKTKICSEF

WFDC6

91

Q9BQY6
GKAFKQSSTLTTHKI

ZNF431

266

Q8TF32
GKAFNQSSTLTKHKK

ZNF93

291

P35789
GKAFVASSTLSKHEI

ZNF93

431

P35789
KAFNLSSTLTAHKKI

ZNF107

671

Q9UII5
GKVFSVFSVLTKHKI

ZNF273

296

Q14593
GKAFSVFSTLTKHKI

ZNF273

436

Q14593
RTGVSFTFSKKVHLK

ZNF804B

216

A4D1E1
FTFSKKVHLKLESSA

ZNF804B

221

A4D1E1
KVHLKLESSASVFSE

ZNF804B

226

A4D1E1
GKAFSKVSTLNTHKA

ZNF676

371

Q8N7Q3
FFKLIHGSGKEETSK

RGS18

21

Q9NS28
SKLSVKPSIFHKDAA

REV3L

551

O60673
IAVSNLHKETKKVFS

RRM1

81

P23921
ATSKKIAHSVFSKGD

SLC27A1

471

Q6PCB7
TISKGHKIQKTSDLK

STOX1

506

Q6ZVD7
GKGFSQSSTLTKHKI

ZNF723

431

P0DPD5
KAFSKASTLTAHKTI

ZNF728

291

P0DKX0
KAFTTFSSLTKHKVI

ZNF728

431

P0DKX0
HSFALLGKKKSSNLT

TPP2

926

P29144
KSQGKTLSAGLKFHE

ZDBF2

276

Q9HCK1
LAHKDTKVSIKVGST

NF1

1746

P21359
HSKLVGTKALSTTGK

TTLL3

596

Q9Y4R7
SHGKGKITKSEFESK

SUCO

206

Q9UBS9
VTGHFLKVTSSASKK

TSHZ2

401

Q9NRE2
KSSEFLKHAGKETIV

SETD2

916

Q9BYW2
TKKIDLSHVTSKCGS

MAP2

1696

P11137
SFKDTSTGHKNKEFV

PRKDC

3541

P78527
KSNSLKKHFFIIGES

XRCC2

261

O43543
GKAFSIFSILTKHKV

ZNF708

426

P17019
ELSKGQLKTKASHST

WDR37

101

Q9Y2I8
ADLFHSIATQKKKVG

USP46

81

P62068
GKAFSKVSTLTTHKA

ZNF208

291

O43345
GKSFSTFSILTKHKV

ZNF208

531

O43345
GKAFSKFSILTKHKV

ZNF208

671

O43345
GKTFSKVSTLTTHKA

ZNF208

811

O43345
GKAFSTFSILTKHKV

ZNF208

1231

O43345
KSHEKYLIALKSSGL

UBR3

291

Q6ZT12
GKTFSISSTFTKHKI

ZNF429

291

Q86V71
GKTFSVFSILTKHKI

ZNF493

311

Q6ZR52
GKSFSVFSTLTKHKI

ZNF493

451

Q6ZR52
GKSFTVKSTLDCHVK

ZNF236

1201

Q9UL36
KVHTKKTAFGTSSAQ

ZNF217

236

O75362
SKIKKIVHSIVSSFA

TPTE2

61

Q6XPS3
KTLTGGKSFSQKSHI

ZNF782

286

Q6ZMW2
GKSISFDTKLVKHEI

ZNF23

146

P17027
KLSTSFVLETFIHSK

USP34

2306

Q70CQ2
GTIAFLKDLSAKTHS

VWA3B

276

Q502W6
DSIKSFTVSLHKENK

UGGT2

1211

Q9NYU1
EDAKLSFKHVSSLKG

ARHGAP21

891

Q5T5U3
SFKHVSSLKGIKIAD

ARHGAP21

896

Q5T5U3
HKFTNASKIIKTDFG

PTPRC

376

P08575
LGKHKHETFITSSGK

VIRMA

1591

Q69YN4
LSGKAHFVSKITSSK

ZNF438

236

Q7Z4V0
GKAFISSSTLTKHEI

ZNF506

291

Q5JVG8
SKIHSLLTKGFINEK

VWA3A

1121

A6NCI4
GTVKTHLTSLKTKFP

TSN

66

Q15631
GKAFKRSSILTAHKI

ZNF737

291

O75373
FNSSDHIESKGIKIK

NAF1

256

Q96HR8