Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	NANOGP1 NANOG	6.83e-05	4	68	2	GO:0001010
GeneOntologyMolecularFunction	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ADAM19 ADAM9	6.83e-05	4	68	2	GO:1902945
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF594 NANOGP1 ZNF33B NANOG ZNF790 ZNF507 AHR ZFHX3 ZNF782 RFX8 ZBED1 TAF1L THAP1 STAT5B ZNF518A	9.31e-05	1459	68	15	GO:0000977
GeneOntologyMolecularFunction	L-ornithine transmembrane transporter activity	SLC25A2 SLC25A15	1.14e-04	5	68	2	GO:0000064
GeneOntologyMolecularFunction	lysine-acetylated histone binding	NANOGP1 NANOG TAF1L	1.44e-04	30	68	3	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	NANOGP1 NANOG TAF1L	1.59e-04	31	68	3	GO:0140033
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF594 NANOGP1 ZNF33B NANOG ZNF790 ZNF507 AHR ZFHX3 ZNF782 RFX8 ZBED1 THAP1 STAT5B ZNF518A	2.43e-04	1412	68	14	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF594 NANOGP1 ZNF33B NANOG ZNF790 ZNF507 AHR ZFHX3 ZNF782 RFX8 ZBED1 THAP1 STAT5B	2.53e-04	1244	68	13	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF594 NANOGP1 ZNF33B NANOG ZNF790 ZNF507 AHR ZFHX3 ZNF782 RFX8 ZBED1 THAP1 STAT5B	3.11e-04	1271	68	13	GO:0000987
GeneOntologyMolecularFunction	L-lysine transmembrane transporter activity	SLC25A2 SLC25A15	4.05e-04	9	68	2	GO:0015189
GeneOntologyMolecularFunction	histone acetyltransferase activity	ING3 BRCA2 TAF1L	7.00e-04	51	68	3	GO:0004402
GeneOntologyMolecularFunction	L-arginine transmembrane transporter activity	SLC25A2 SLC25A15	8.70e-04	13	68	2	GO:0061459
GeneOntologyMolecularFunction	insulin-like growth factor I binding	IGF1R LRP2	8.70e-04	13	68	2	GO:0031994
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	ING3 BRCA2 TAF1L	8.73e-04	55	68	3	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	ING3 BRCA2 TAF1L	1.13e-03	60	68	3	GO:0034212
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP2 LRP1B	1.33e-03	16	68	2	GO:0005041
GeneOntologyMolecularFunction	insulin-like growth factor binding	IGF1R LRP2	1.88e-03	19	68	2	GO:0005520
GeneOntologyMolecularFunction	basic amino acid transmembrane transporter activity	SLC25A2 SLC25A15	2.09e-03	20	68	2	GO:0015174
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP2 LRP1B	2.30e-03	21	68	2	GO:0030228
GeneOntologyMolecularFunction	N-acetyltransferase activity	ING3 BRCA2 TAF1L	2.39e-03	78	68	3	GO:0008080
GeneOntologyMolecularFunction	histone H4 acetyltransferase activity	ING3 BRCA2	2.76e-03	23	68	2	GO:0010485
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF594 NANOGP1 ZNF33B NANOG ZNF782 ZBED1 STAT5B	2.90e-03	560	68	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF594 NANOGP1 ZNF33B NANOG ZNF782 ZBED1 STAT5B	3.08e-03	566	68	7	GO:0001216
GeneOntologyMolecularFunction	RNA polymerase II general transcription initiation factor binding	AHR TAF1L	3.80e-03	27	68	2	GO:0001091
GeneOntologyMolecularFunction	transcription factor binding	TTC8 NANOGP1 PHF12 NANOG AHR LRP2 TAF1L STAT5B	3.95e-03	753	68	8	GO:0008134
GeneOntologyBiologicalProcess	mitochondrial L-ornithine transmembrane transport	SLC25A2 SLC25A15	3.21e-05	3	68	2	GO:1990575
GeneOntologyBiologicalProcess	regulation of cell division	EREG IGF1R NANOGP1 BRCA2 NANOG KIF20B	5.26e-05	201	68	6	GO:0051302
GeneOntologyBiologicalProcess	negative regulation of endodermal cell fate specification	NANOGP1 NANOG	6.40e-05	4	68	2	GO:0042664
GeneOntologyBiologicalProcess	regulation of endodermal cell fate specification	NANOGP1 NANOG	1.06e-04	5	68	2	GO:0042663
GeneOntologyBiologicalProcess	regulation of mitotic cell cycle	EREG IGF1R NANOGP1 BRCA2 NANOG THAP1 KIF20B USP47 STAT5B	1.39e-04	594	68	9	GO:0007346
GeneOntologyBiologicalProcess	L-ornithine transmembrane transport	SLC25A2 SLC25A15	1.59e-04	6	68	2	GO:1903352
GeneOntologyBiologicalProcess	negative regulation of endodermal cell differentiation	NANOGP1 NANOG	1.59e-04	6	68	2	GO:1903225
GeneOntologyBiologicalProcess	female sex differentiation	EREG BRCA2 AHR LRP2 STAT5B	1.70e-04	157	68	5	GO:0046660
GeneOntologyBiologicalProcess	ornithine transport	SLC25A2 SLC25A15	2.23e-04	7	68	2	GO:0015822
Domain	EGF_3	FBLN1 EREG ADAM19 FBN2 ADAM9 LRP2 LRP1B ADGRL4	1.71e-06	235	66	8	PS50026
Domain	cEGF	FBLN1 FBN2 LRP2 LRP1B	2.01e-06	26	66	4	IPR026823
Domain	cEGF	FBLN1 FBN2 LRP2 LRP1B	2.01e-06	26	66	4	PF12662
Domain	EGF-like_dom	FBLN1 EREG ADAM19 FBN2 ADAM9 LRP2 LRP1B ADGRL4	2.63e-06	249	66	8	IPR000742
Domain	EGF-like_CS	FBLN1 EREG ADAM19 FBN2 ADAM9 LRP2 LRP1B ADGRL4	3.73e-06	261	66	8	IPR013032
Domain	EGF_2	FBLN1 EREG ADAM19 FBN2 ADAM9 LRP2 LRP1B ADGRL4	4.17e-06	265	66	8	PS01186
Domain	EGF_CA	FBLN1 FBN2 LRP2 LRP1B ADGRL4	1.32e-05	86	66	5	PF07645
Domain	EGF	FBLN1 EREG FBN2 ADAM9 LRP2 LRP1B ADGRL4	1.89e-05	235	66	7	SM00181
Domain	EGF_Ca-bd_CS	FBLN1 FBN2 LRP2 LRP1B ADGRL4	2.37e-05	97	66	5	IPR018097
Domain	EGF_CA	FBLN1 FBN2 LRP2 LRP1B ADGRL4	2.61e-05	99	66	5	PS01187
Domain	ASX_HYDROXYL	FBLN1 FBN2 LRP2 LRP1B ADGRL4	2.74e-05	100	66	5	PS00010
Domain	EGF_1	FBLN1 EREG ADAM19 FBN2 ADAM9 LRP2 LRP1B	3.19e-05	255	66	7	PS00022
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN1 FBN2 LRP2 LRP1B ADGRL4	3.63e-05	106	66	5	IPR000152
Domain	EGF_extracell	ADAM19 ADAM9 LRP2 LRP1B	5.98e-05	60	66	4	IPR013111
Domain	EGF_2	ADAM19 ADAM9 LRP2 LRP1B	5.98e-05	60	66	4	PF07974
Domain	EGF_CA	FBLN1 FBN2 LRP2 LRP1B ADGRL4	7.12e-05	122	66	5	SM00179
Domain	EGF-like_Ca-bd_dom	FBLN1 FBN2 LRP2 LRP1B ADGRL4	7.69e-05	124	66	5	IPR001881
Domain	Growth_fac_rcpt_	FBLN1 IGF1R FBN2 LRP2 LRP1B	2.26e-04	156	66	5	IPR009030
Domain	Ldl_recept_b	LRP2 LRP1B	1.09e-03	14	66	2	PF00058
Domain	LDLRB	LRP2 LRP1B	1.09e-03	14	66	2	PS51120
Domain	LY	LRP2 LRP1B	1.25e-03	15	66	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP1B	1.25e-03	15	66	2	IPR000033
Domain	Disintegrin_CS	ADAM19 ADAM9	1.43e-03	16	66	2	IPR018358
Domain	ADAM_CR	ADAM19 ADAM9	1.81e-03	18	66	2	PF08516
Domain	-	ADAM19 ADAM9	2.24e-03	20	66	2	4.10.70.10
Domain	Disintegrin	ADAM19 ADAM9	2.47e-03	21	66	2	PF00200
Domain	DISIN	ADAM19 ADAM9	2.47e-03	21	66	2	SM00050
Domain	ACR	ADAM19 ADAM9	4.08e-03	27	66	2	SM00608
Domain	ADAM_Cys-rich	ADAM19 ADAM9	4.08e-03	27	66	2	IPR006586
Domain	Aden_trnslctor	SLC25A2 SLC25A15	4.38e-03	28	66	2	IPR002113
Domain	ZnF_U1	CIZ1 ZFHX3	4.70e-03	29	66	2	SM00451
Domain	Znf_U1	CIZ1 ZFHX3	4.70e-03	29	66	2	IPR003604
Domain	ZINC_FINGER_C2H2_1	ZNF594 ZNF33B ZNF790 ZNF507 CIZ1 ZFHX3 ZNF782 ZNF518A	5.90e-03	777	66	8	PS00028
Domain	Znf_C2H2-like	ZNF594 ZNF33B ZNF790 ZNF507 CIZ1 ZFHX3 ZNF782 ZNF518A	6.79e-03	796	66	8	IPR015880
Domain	Znf_C2H2	ZNF594 ZNF33B ZNF790 ZNF507 CIZ1 ZFHX3 ZNF782 ZNF518A	7.25e-03	805	66	8	IPR007087
Domain	ZnF_C2H2	ZNF594 ZNF33B ZNF790 ZNF507 CIZ1 ZFHX3 ZNF782 ZNF518A	7.41e-03	808	66	8	SM00355
Domain	Peptidase_M12B_N	ADAM19 ADAM9	8.38e-03	39	66	2	IPR002870
Domain	Pep_M12B_propep	ADAM19 ADAM9	8.38e-03	39	66	2	PF01562
Domain	-	LRP2 LRP1B	8.38e-03	39	66	2	2.120.10.30
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	NANOGP1 NANOG LRP2 LRP1B	8.28e-08	21	69	4	21337463
Pubmed	Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.	NANOGP1 NANOG LRP2	1.22e-06	11	69	3	18083160
Pubmed	Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.	SLC25A2 SLC25A15	3.88e-06	2	69	2	12948741
Pubmed	Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin conformation via aryl hydrocarbon receptor.	NANOG AHR	3.88e-06	2	69	2	32169107
Pubmed	On the origin and evolutionary history of NANOG.	NANOGP1 NANOG	3.88e-06	2	69	2	24465486
Pubmed	Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway.	IGF1R AHR	3.88e-06	2	69	2	35083738
Pubmed	NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells.	NANOGP1 NANOG	3.88e-06	2	69	2	36621005
Pubmed	Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I.	IGF1R LRP2	3.88e-06	2	69	2	16306401
Pubmed	Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.	SLC25A2 SLC25A15	3.88e-06	2	69	2	22262851
Pubmed	The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.	SLC25A2 SLC25A15	3.88e-06	2	69	2	12807890
Pubmed	Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells.	NANOGP1 NANOG	3.88e-06	2	69	2	20427424
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ING3 NANOGP1 NANOG ZNF790 ZNF507 CIZ1 AHR ZFHX3 ZC3H6 STAT5B	4.28e-06	808	69	10	20412781
Pubmed	The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development.	NANOGP1 NANOG AHR	7.08e-06	19	69	3	34478649
Pubmed	A metalloprotease-disintegrin participating in myoblast fusion.	ADAM19 ADAM9	1.16e-05	3	69	2	7566181
Pubmed	Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.	NANOGP1 NANOG	1.16e-05	3	69	2	19447925
Pubmed	The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.	NANOGP1 NANOG	1.16e-05	3	69	2	30814124
Pubmed	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	30846691
Pubmed	Generation of germline-competent induced pluripotent stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	17554338
Pubmed	Multiple phases in regulation of Nanog expression during pre-implantation development.	NANOGP1 NANOG	1.16e-05	3	69	2	26660234
Pubmed	Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.	NANOGP1 NANOG	1.16e-05	3	69	2	18177668
Pubmed	Expression of Nanog gene promotes NIH3T3 cell proliferation.	NANOGP1 NANOG	1.16e-05	3	69	2	16259959
Pubmed	A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	12609610
Pubmed	Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.	NANOGP1 NANOG	1.16e-05	3	69	2	24227785
Pubmed	Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.	NANOGP1 NANOG	1.16e-05	3	69	2	24929238
Pubmed	Nanog and transcriptional networks in embryonic stem cell pluripotency.	NANOGP1 NANOG	1.16e-05	3	69	2	17211451
Pubmed	The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.	NANOGP1 NANOG	1.16e-05	3	69	2	23770853
Pubmed	The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.	NANOGP1 NANOG	1.16e-05	3	69	2	15502159
Pubmed	Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.	NANOGP1 NANOG	1.16e-05	3	69	2	20574542
Pubmed	lincRNAs act in the circuitry controlling pluripotency and differentiation.	NANOGP1 NANOG	1.16e-05	3	69	2	21874018
Pubmed	Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.	NANOGP1 NANOG	1.16e-05	3	69	2	23054952
Pubmed	Nanog-independent reprogramming to iPSCs with canonical factors.	NANOGP1 NANOG	1.16e-05	3	69	2	24527385
Pubmed	Aromatic residues in the C-terminal domain 2 are required for Nanog to mediate LIF-independent self-renewal of mouse embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	18086680
Pubmed	Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12.	AHR MAP3K12	1.16e-05	3	69	2	30009782
Pubmed	Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	17204467
Pubmed	CrxOS maintains the self-renewal capacity of murine embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	19800316
Pubmed	Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	23200040
Pubmed	Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.	NANOGP1 NANOG	1.16e-05	3	69	2	26975336
Pubmed	Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.	NANOGP1 NANOG	1.16e-05	3	69	2	23329853
Pubmed	NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.	NANOGP1 NANOG	1.16e-05	3	69	2	26751055
Pubmed	Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	17352742
Pubmed	OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.	NANOGP1 NANOG	1.16e-05	3	69	2	23178592
Pubmed	Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency.	NANOGP1 NANOG	1.16e-05	3	69	2	25005472
Pubmed	Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.	NANOGP1 NANOG	1.16e-05	3	69	2	16773043
Pubmed	Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.	NANOGP1 NANOG	1.16e-05	3	69	2	23665121
Pubmed	Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.	NANOGP1 NANOG	1.16e-05	3	69	2	26733157
Pubmed	mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells.	NANOGP1 NANOG	1.16e-05	3	69	2	23071603
Pubmed	Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.	NANOGP1 NANOG	1.16e-05	3	69	2	16501172
Pubmed	Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	19582141
Pubmed	NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.	NANOGP1 NANOG	1.16e-05	3	69	2	21119109
Pubmed	Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	32145514
Pubmed	Nanog is the gateway to the pluripotent ground state.	NANOGP1 NANOG	1.16e-05	3	69	2	19703398
Pubmed	Nanog safeguards pluripotency and mediates germline development.	NANOGP1 NANOG	1.16e-05	3	69	2	18097409
Pubmed	Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.	NANOGP1 NANOG	1.16e-05	3	69	2	28636920
Pubmed	Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst.	NANOGP1 NANOG	1.16e-05	3	69	2	25753417
Pubmed	Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling.	IGF1R STAT5B	1.16e-05	3	69	2	20133448
Pubmed	A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.	NANOGP1 NANOG	1.16e-05	3	69	2	20539761
Pubmed	High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases.	ADAM19 ADAM9	1.16e-05	3	69	2	23429442
Pubmed	Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.	NANOGP1 NANOG	1.16e-05	3	69	2	18584034
Pubmed	Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	21969378
Pubmed	The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.	NANOGP1 NANOG	1.16e-05	3	69	2	20661723
Pubmed	NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.	NANOGP1 NANOG	1.16e-05	3	69	2	29245050
Pubmed	Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.	NANOGP1 NANOG	1.16e-05	3	69	2	22337995
Pubmed	The pluripotency rheostat Nanog functions as a dimer.	NANOGP1 NANOG	1.16e-05	3	69	2	18290762
Pubmed	Reprogramming of mouse fibroblasts into induced pluripotent stem cells with Nanog.	NANOGP1 NANOG	1.16e-05	3	69	2	23333380
Pubmed	Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.	NANOGP1 NANOG	1.16e-05	3	69	2	15494369
Pubmed	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	25825768
Pubmed	Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation.	NANOGP1 NANOG	1.16e-05	3	69	2	31891567
Pubmed	Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.	NANOGP1 NANOG	1.16e-05	3	69	2	14728807
Pubmed	Isolation and characterization of the murine Nanog gene promoter.	NANOGP1 NANOG	1.16e-05	3	69	2	15916719
Pubmed	Nanog retrotransposed genes with functionally conserved open reading frames.	NANOGP1 NANOG	1.16e-05	3	69	2	16845474
Pubmed	Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.	NANOGP1 NANOG	1.16e-05	3	69	2	21194951
Pubmed	Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.	NANOGP1 NANOG	1.16e-05	3	69	2	22388986
Pubmed	NANOG changes in mouse kidneys with age.	NANOGP1 NANOG	1.16e-05	3	69	2	16313224
Pubmed	Nanog promotes transfer of pluripotency after cell fusion.	NANOGP1 NANOG	1.16e-05	3	69	2	16791199
Pubmed	Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6.	NANOGP1 NANOG	1.16e-05	3	69	2	33665763
Pubmed	Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	18024963
Pubmed	The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	27125671
Pubmed	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.	NANOGP1 NANOG	1.16e-05	3	69	2	22028025
Pubmed	Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming.	NANOGP1 NANOG	1.16e-05	3	69	2	28457890
Pubmed	Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.	NANOGP1 NANOG	1.16e-05	3	69	2	18436640
Pubmed	NRIF is a regulator of neuronal cholesterol biosynthesis genes.	DHCR7 HMGCR	1.16e-05	3	69	2	18677445
Pubmed	Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	25410303
Pubmed	Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.	NANOGP1 NANOG	1.16e-05	3	69	2	33334884
Pubmed	NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.	NANOGP1 NANOG	1.16e-05	3	69	2	21499299
Pubmed	Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.	NANOGP1 NANOG	1.16e-05	3	69	2	33107035
Pubmed	Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder.	NANOGP1 NANOG	1.16e-05	3	69	2	17360937
Pubmed	H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate.	NANOGP1 NANOG	1.16e-05	3	69	2	35976266
Pubmed	Nanog dynamics in single embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	26760119
Pubmed	Nanog is dispensable for the generation of induced pluripotent stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	24461999
Pubmed	Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.	NANOGP1 NANOG	1.16e-05	3	69	2	30837263
Pubmed	Nanog induces hyperplasia without initiating tumors.	NANOGP1 NANOG	1.16e-05	3	69	2	25173648
Pubmed	Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.	NANOGP1 NANOG	1.16e-05	3	69	2	27939294
Pubmed	Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.	NANOGP1 NANOG	1.16e-05	3	69	2	24681518
Pubmed	Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming.	NANOGP1 NANOG	1.16e-05	3	69	2	26549484
Pubmed	Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.	NANOGP1 NANOG	1.16e-05	3	69	2	18442017
Pubmed	Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.	NANOGP1 NANOG	1.16e-05	3	69	2	21187909
Pubmed	Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter.	NANOGP1 NANOG	1.16e-05	3	69	2	16541131
Pubmed	Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.	NANOGP1 NANOG	1.16e-05	3	69	2	22142851
Pubmed	NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.	NANOGP1 NANOG	1.16e-05	3	69	2	24462001
Pubmed	A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.	NANOGP1 NANOG	1.16e-05	3	69	2	16790525
Interaction	IGFL3 interactions	FBLN1 FBN2 ADAM9 LRP2 LRP1B	4.67e-06	75	66	5	int:IGFL3
Interaction	MFAP5 interactions	FBLN1 FBN2 ZNF507 AHR	2.52e-05	52	66	4	int:MFAP5
Interaction	ZFP41 interactions	FBLN1 FBN2 LRP2 LRP1B	3.64e-05	57	66	4	int:ZFP41
Interaction	DEFB125 interactions	FBLN1 FBN2 LRP2	3.68e-05	20	66	3	int:DEFB125
Interaction	ZNF224 interactions	FBN2 LRP2 LRP1B	3.68e-05	20	66	3	int:ZNF224
Interaction	NTN5 interactions	FBN2 LRP2 LRP1B	6.46e-05	24	66	3	int:NTN5
Interaction	FIBIN interactions	IGF1R ADAM19 ADAM9 PTPRU	8.64e-05	71	66	4	int:FIBIN
GeneFamily	Low density lipoprotein receptors	LRP2 LRP1B	6.44e-04	13	53	2	634
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRCA2 FANCL	1.55e-03	20	53	2	548
GeneFamily	PHD finger proteins	ING3 PHF12 FANCL	2.33e-03	90	53	3	88
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM19 ADAM9	2.82e-03	27	53	2	47
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF594 ZNF33B ZNF790 ZNF507 ZFHX3 ZNF782 ZNF518A	4.76e-03	718	53	7	28
Drug	Epi Lovastatin	EREG IGF1R DHCR7 LRP2 HMGCR LRP1B GOT2 ADGRL4	7.05e-06	341	67	8	CID000003962
Drug	AC1L1GHE	EREG FBN2 AHR TAF1L ADGRL4	9.42e-06	96	67	5	CID000003684
Drug	Nitrogen Mustard Compounds	IGF1R BRCA2 AHR	2.28e-05	19	67	3	ctd:D009588
Drug	Procainamide hydrochloride [614-39-1]; Down 200; 14.8uM; PC3; HT_HG-U133A	FBLN1 TRIM62 GPC4 CIZ1 IL1RAP MAP3K12	2.30e-05	194	67	6	4602_DN
Drug	Thiethylperazine malate [52239-63-1]; Down 200; 6uM; MCF7; HT_HG-U133A	PDSS2 CIZ1 PTPRU IL1RAP THAP1 STAT5B	2.50e-05	197	67	6	6232_DN
Drug	5-hydroxyindolepyruvate	AHR GOT2	2.55e-05	3	67	2	CID000440742
Drug	piperine	IGF1R AHR HMGCR STAT5B	2.76e-05	59	67	4	ctd:C008922
Disease	Prostatic Neoplasms	FBLN1 BRCA2 ADAM9 CIZ1 AHR LRP2 ZFHX3 ZBED1 TAF1L LRP1B	9.32e-07	616	65	10	C0033578
Disease	Malignant neoplasm of prostate	FBLN1 BRCA2 ADAM9 CIZ1 AHR LRP2 ZFHX3 ZBED1 TAF1L LRP1B	9.32e-07	616	65	10	C0376358
Disease	ornithine translocase deficiency (implicated_via_orthology)	SLC25A2 SLC25A15	4.78e-06	2	65	2	DOID:0050720 (implicated_via_orthology)
Disease	WILMS TUMOR 1	BRCA2 GPC4	7.13e-05	6	65	2	194070
Disease	Wilms tumor 1	BRCA2 GPC4	7.13e-05	6	65	2	cv:CN033288
Disease	ocular sarcoidosis	IGF1R FBN2 LRP2 INVS	1.28e-04	116	65	4	EFO_0010723
Disease	Nephroblastoma	BRCA2 GPC4	1.33e-04	8	65	2	cv:C0027708
Disease	Hereditary Wilms tumor	BRCA2 GPC4	1.33e-04	8	65	2	cv:C0677779
Disease	Kidney Wilms tumor	BRCA2 GPC4	1.33e-04	8	65	2	cv:CN305775
Disease	Malignant tumor of prostate	BRCA2 ZFHX3	1.70e-04	9	65	2	cv:C0376358
Disease	colon cancer (implicated_via_orthology)	NANOGP1 NANOG	2.59e-04	11	65	2	DOID:219 (implicated_via_orthology)
Disease	dementia (is_implicated_in)	IGF1R HMGCR	3.11e-04	12	65	2	DOID:1307 (is_implicated_in)
Disease	Metabolic Bone Disorder	DHCR7 LRP2	4.27e-04	14	65	2	C0005944
Disease	membranous glomerulonephritis (biomarker_via_orthology)	LRP2 PTPRU	4.27e-04	14	65	2	DOID:10976 (biomarker_via_orthology)
Disease	nephroblastoma (is_implicated_in)	IGF1R BRCA2	4.27e-04	14	65	2	DOID:2154 (is_implicated_in)
Disease	Fanconi anemia	BRCA2 FANCL	4.27e-04	14	65	2	cv:C0015625
Disease	Osteopenia	DHCR7 LRP2	4.93e-04	15	65	2	C0029453
Disease	coffee consumption, cups of coffee per day measurement	PDSS2 AHR	5.62e-04	16	65	2	EFO_0004330, EFO_0006782
Disease	Dystonia, Limb	CIZ1 THAP1	6.36e-04	17	65	2	C0751093
Disease	Dystonia, Diurnal	CIZ1 THAP1	6.36e-04	17	65	2	C0393610
Disease	hypertrophic cardiomyopathy (is_marker_for)	IGF1R ADGRL4	6.36e-04	17	65	2	DOID:11984 (is_marker_for)
Disease	Bone marrow hypocellularity	BRCA2 FANCL	7.15e-04	18	65	2	C1855710
Disease	Dystonia, Paroxysmal	CIZ1 THAP1	7.15e-04	18	65	2	C0393588
Disease	Splenomegaly	AHR STAT5B	1.07e-03	22	65	2	C0038002
Disease	nephrosis (biomarker_via_orthology)	LRP2 PTPRU	1.07e-03	22	65	2	DOID:2527 (biomarker_via_orthology)
Disease	Disorder of eye	TTC8 MYO7A ADAM9 INVS	1.24e-03	212	65	4	C0015397
Disease	Neoplasm of the genitourinary tract	BRCA2 ZFHX3	1.28e-03	24	65	2	cv:C0042065
Disease	Fanconi Anemia	BRCA2 FANCL	1.39e-03	25	65	2	C0015625
Disease	Pancytopenia	BRCA2 FANCL	1.50e-03	26	65	2	C0030312
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	TACR1 ADGRL4	1.74e-03	28	65	2	DOID:1094 (implicated_via_orthology)
Disease	Ciliopathies	TTC8 MYO7A INVS	1.86e-03	110	65	3	C4277690
Disease	Miller Dieker syndrome	BRCA2 FANCL	1.87e-03	29	65	2	C0265219
Disease	Bilateral Wilms Tumor	BRCA2 GPC4	1.87e-03	29	65	2	C2930471

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENANCTNTEGSYYCM	ADGRL4	71	Q9HBW9
PQTCYAGAVSMYQCQ	AHR	761	P35869
AYCYNGMCLTYQEQC	ADAM19	511	Q9H013
YYKNQQMCCVSTSIV	GVINP1	1036	Q7Z2Y8
MGLDETQCYQVTCYL	APOBEC3H	66	Q6NTF7
SCQNYDMVSGIYSCQ	PDSS2	131	Q86YH6
YFIMACDQYSCALTG	DHCR7	56	Q9UBM7
TILNCYTCAYMNDQG	ACRV1	186	P26436
RSYTMESSYCGCNQG	AGBL1	981	Q96MI9
GYYQCVAENSAGMAC	IGDCC4	401	Q8TDY8
YNISMGDNTITYNAC	OR6C2	81	Q9NZP2
EEMQCQVCYDLGAAY	INTS8	246	Q75QN2
MYYSCNGEELTLSNC	CD6	326	P30203
TRTCMCTVGYYLQKN	LRP1B	1856	Q9NZR2
CTVGYYLQKNRMSCQ	LRP1B	1861	Q9NZR2
CYNYCSNIMRGCLAN	GPC4	266	O75487
NYTCMLRNTTYCSKV	IL1RAP	111	Q9NPH3
DYNYSLVMGACCENV	HMGCR	516	P04035
MCEKTTINNEYNYRC	IGF1R	191	P08069
RYCICNQVSYGEMVG	ING3	361	Q9NXR8
CMIVNISQCYLAYDE	KIF20B	451	Q96Q89
YNCGEESLQSCMQFQ	NANOG	241	Q9H9S0
YCSMTLCSALNCQYQ	LRP2	306	P98164
EYQSYSQYQSCCSCM	FAM170B	81	A6NMN3
GCNYSDNYQELMDSQ	FAM131B	161	Q86XD5
ALNQVCSNFLYYMCL	MEI1	621	Q5TIA1
YDYGCTSIVMLNQLN	PTPRU	1266	Q92729
CEYSLMVGYQCGQVF	FBLN1	126	P23142
NCEIYYQSPLSLCMA	BRCA2	3221	P51587
QGACQTYCTRQETYM	DEFB124	31	Q8NES8
MCQYYDAQCQVIFGS	ADAM9	516	Q13443
YCILMEFCAQGQLYE	MAP3K12	186	Q12852
VAQKTMDYVCCAYNN	HEPACAM2	306	A8MVW5
MDYVCCAYNNITGRQ	HEPACAM2	311	A8MVW5
DMSQNYCRCEVGYTG	EREG	86	O14944
SYRCECNMGYKQDAN	FBN2	516	P35556
FQQLMVETCSCGYYL	SCNN1D	561	P51172
SMYCQFASFQYTCQP	DKK3	156	Q9UBP4
QCAAYGGYINCMAVL	INVS	461	Q9Y283
SDFTMDCGICYAYQL	FANCL	301	Q9NW38
PEQCCAYYSMIAAKQ	TAF1L	901	Q8IZX4
SSTMYNPIIYCCLND	TACR1	296	P25103
ADMDVCLTNYGHCNY	PHF12	821	Q96QT6
DYSGEILNNCCVMEY	STAT5B	391	P51692
GAQMCYLCRVSINGY	RNF216	696	Q9NWF9
CLMGNCQYVQLQDYI	NUP160	881	Q12769
AENSVLFMCYGFCQQ	SLC25A15	76	Q9Y619
AENSVLFMCYGFCQQ	SLC25A2	76	Q9BXI2
VCLCQSYAKNMGLYG	GOT2	271	P00505
CNTCQLYYMGDLIQH	CIZ1	656	Q9ULV3
NYCVRYMGCVEVLQS	SHC4	191	Q6S5L8
MICATNYGENLCYGD	PRSS45P	171	Q7RTY3
NLGLCCFYAQQYDMT	TTC8	391	Q8TAM2
LQGYCTKGENCIYMH	ZC3H6	311	P61129
MLENYSNLVSVGYCA	ZNF33B	41	Q06732
MVQECCSQSLYYEEL	LINC00643	1	Q86TS7
NCYSYALTFINCVLM	MKRN2OS	151	H3BPM6
CLMYEIYVETCGQNT	RFX8	41	Q6ZV50
MVQSCSAYGCKNRYD	THAP1	1	Q9NVV9
GYVGLVNQAMTCYLN	USP47	186	Q96K76
AQQNSYDCGMYVICN	SENP8	156	Q96LD8
NSGDMHNYCINYGNC	ZNF518A	611	Q6AHZ1
PFYNCGEESLQSCMQ	NANOGP1	166	Q8N7R0
GMYRCLFCSYTCGQQ	ZNF507	246	Q8TCN5
ENYSNMVSLGFCIYQ	ZNF790	36	Q6PG37
PYECYDCGQMFSQSS	ZNF594	266	Q96JF6
YEYNECGKSCSMNSH	ZNF782	366	Q6ZMW2
YCRICMAQIAYSGNT	ZBED1	46	O96006
FACYCTNMENTYGLE	SLC26A7	271	Q8TE54
FYCIVMHDGNQYSAC	TRIM62	386	Q9BVG3
QMYQCPYCKYSNADV	ZFHX3	1221	Q15911
SDYNYLAMGNCITCE	MYO7A	276	Q13402