Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	signal recognition particle binding	DERL3 DERL2	1.77e-04	8	51	2	GO:0005047
GeneOntologyCellularComponent	endosome	GAPVD1 ATP6V0A1 SLC11A2 MYO1D DERL2 ABCB6 ATP11C ACKR2 GNAS MARCHF1 TLR8	7.81e-05	1167	50	11	GO:0005768
GeneOntologyCellularComponent	ATP-binding cassette (ABC) transporter complex	ABCB6 ABCG5	8.36e-05	6	50	2	GO:0043190
GeneOntologyCellularComponent	early endosome	SLC11A2 MYO1D DERL2 ABCB6 ATP11C ACKR2 MARCHF1	1.39e-04	481	50	7	GO:0005769
GeneOntologyCellularComponent	ATPase dependent transmembrane transport complex	ATP6V0A1 ABCB6 ABCG5	3.09e-04	55	50	3	GO:0098533
GeneOntologyCellularComponent	lysosomal membrane	ATP6V0A1 SLC11A2 ABCB6 ATP11C MARCHF1 TLR8	7.87e-04	462	50	6	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	ATP6V0A1 SLC11A2 ABCB6 ATP11C MARCHF1 TLR8	7.87e-04	462	50	6	GO:0098852
GeneOntologyCellularComponent	endolysosome membrane	ABCB6 TLR8	1.04e-03	20	50	2	GO:0036020
GeneOntologyCellularComponent	axolemma	ADORA1 MYO1D	1.14e-03	21	50	2	GO:0030673
GeneOntologyCellularComponent	vacuolar membrane	ATP6V0A1 SLC11A2 ABCB6 ATP11C MARCHF1 TLR8	1.27e-03	507	50	6	GO:0005774
GeneOntologyCellularComponent	early endosome membrane	SLC11A2 ABCB6 ATP11C MARCHF1	1.64e-03	212	50	4	GO:0031901
GeneOntologyCellularComponent	recycling endosome	SLC11A2 ATP11C ACKR2 GNAS	1.95e-03	222	50	4	GO:0055037
GeneOntologyCellularComponent	endolysosome	ABCB6 TLR8	2.34e-03	30	50	2	GO:0036019
GeneOntologyCellularComponent	lysosome	ATP6V0A1 SLC11A2 ABCB6 ATP11C TNFAIP3 MARCHF1 TLR8	3.01e-03	811	50	7	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	ATP6V0A1 SLC11A2 ABCB6 ATP11C TNFAIP3 MARCHF1 TLR8	3.01e-03	811	50	7	GO:0000323
GeneOntologyCellularComponent	endosome membrane	ATP6V0A1 SLC11A2 ABCB6 ATP11C MARCHF1 TLR8	3.01e-03	602	50	6	GO:0010008
MousePheno	pancreas lipomatosis	HNF1B PKD1	8.81e-06	2	42	2	MP:0003338
Domain	DER1	DERL3 DERL2	2.10e-05	3	50	2	IPR007599
Domain	Homeobox	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	3.64e-05	234	50	6	PF00046
Domain	HOMEOBOX_1	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	3.81e-05	236	50	6	PS00027
Domain	HOX	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	3.90e-05	237	50	6	SM00389
Domain	HOMEOBOX_2	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	4.09e-05	239	50	6	PS50071
Domain	Homeobox_dom	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	4.09e-05	239	50	6	IPR001356
Domain	HXA9/HXB9/HXC9	HOXA9 HOXC9	4.20e-05	4	50	2	IPR017112
Domain	Hox9_act	HOXA9 HOXC9	4.20e-05	4	50	2	PF04617
Domain	Hox9_activation_N	HOXA9 HOXC9	4.20e-05	4	50	2	IPR006711
Domain	Rho_GTPase_activation_prot	ARHGAP6 GAPVD1 MYO9A ARHGAP25	8.98e-05	88	50	4	IPR008936
Domain	-	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	1.04e-04	283	50	6	1.10.10.60
Domain	Homeodomain-like	HOXA9 HNF1B HOXC9 PKNOX1 NOTO LHX9	2.48e-04	332	50	6	IPR009057
Domain	RhoGAP	ARHGAP6 MYO9A ARHGAP25	6.11e-04	62	50	3	SM00324
Domain	RhoGAP	ARHGAP6 MYO9A ARHGAP25	6.40e-04	63	50	3	PF00620
Domain	RHOGAP	ARHGAP6 MYO9A ARHGAP25	6.70e-04	64	50	3	PS50238
Domain	RhoGAP_dom	ARHGAP6 MYO9A ARHGAP25	6.70e-04	64	50	3	IPR000198
Domain	-	ARHGAP6 MYO9A ARHGAP25	6.70e-04	64	50	3	1.10.555.10
Domain	TAS2R	TAS2R31 TAS2R20	2.19e-03	26	50	2	PF05296
Domain	T2R	TAS2R31 TAS2R20	2.19e-03	26	50	2	IPR007960
Domain	Myosin_head_motor_dom	MYO1D MYO9A	4.64e-03	38	50	2	IPR001609
Domain	MYOSIN_MOTOR	MYO1D MYO9A	4.64e-03	38	50	2	PS51456
Domain	Myosin_head	MYO1D MYO9A	4.64e-03	38	50	2	PF00063
Domain	MYSc	MYO1D MYO9A	4.64e-03	38	50	2	SM00242
Domain	P-loop_NTPase	NLRP9 MYO1D MYO9A ABCB6 GNAS ABCG5 DNAH14	7.06e-03	848	50	7	IPR027417
Domain	ABC_tran	ABCB6 ABCG5	7.32e-03	48	50	2	PF00005
Domain	ABC_TRANSPORTER_2	ABCB6 ABCG5	7.32e-03	48	50	2	PS50893
Domain	ABC_TRANSPORTER_1	ABCB6 ABCG5	7.62e-03	49	50	2	PS00211
Domain	ABC_transporter-like	ABCB6 ABCG5	7.93e-03	50	50	2	IPR003439
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	SLC11A2 NUP155 DERL3 DERL2 ABCB6 ABCG5	9.69e-06	177	40	6	M27476
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP6V0A1 SLC11A2 GLTP DERL3 DERL2 ABCB6 ATP11C GNAS ABCG5 ANO8	1.47e-05	681	40	10	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP6V0A1 SLC11A2 GLTP DERL3 DERL2 ABCB6 ATP11C GNAS ABCG5 ANO8	2.88e-05	736	40	10	M27287
Pathway	REACTOME_ABC_TRANSPORTER_DISORDERS	DERL3 DERL2 ABCB6 ABCG5	6.81e-05	78	40	4	M27473
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	DERL3 DERL2 ABCB6 ABCG5	1.72e-04	99	40	4	MM14986
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	DERL3 DERL2 ABCB6 ABCG5	2.01e-04	103	40	4	M758
Pathway	KEGG_TASTE_TRANSDUCTION	TAS2R31 GNAS TAS2R20	4.25e-04	52	40	3	M5785
Pubmed	Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action.	ADORA1 EPB41L2	2.11e-06	2	51	2	12974671
Pubmed	USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection.	TNFAIP3 USP48	2.11e-06	2	51	2	35913642
Pubmed	Mutations in multiple PKD genes may explain early and severe polycystic kidney disease.	HNF1B PKD1	6.32e-06	3	51	2	22034641
Pubmed	The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis.	HOXA9 PKNOX1	6.32e-06	3	51	2	24809472
Pubmed	Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.	HNF1B PKD1	6.32e-06	3	51	2	37953472
Pubmed	Kinetics of ternary complex formation with fusion proteins composed of the A(1)-adenosine receptor and G protein alpha-subunits.	ADORA1 GNAS	6.32e-06	3	51	2	10521440
Pubmed	Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.	DERL3 DERL2	1.26e-05	4	51	2	32858914
Pubmed	A membrane protein required for dislocation of misfolded proteins from the ER.	DERL3 DERL2	1.26e-05	4	51	2	15215855
Pubmed	MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease.	HNF1B PKD1	1.26e-05	4	51	2	26677864
Pubmed	Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.	PDILT MARCHF1	1.26e-05	4	51	2	24578125
Pubmed	Derlin-dependent accumulation of integral membrane proteins at cell surfaces.	DERL3 DERL2	2.10e-05	5	51	2	19509052
Pubmed	Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.	DERL3 DERL2	2.10e-05	5	51	2	16449189
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	ATP6V0A1 DERL2 ABCB6 ATP11C GNAS SNRPE	2.32e-05	392	51	6	33144569
Pubmed	Global gene expression analysis of murine limb development.	HOXA9 HOXC9 PKNOX1 LHX9	2.69e-05	117	51	4	22174793
Pubmed	Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1.	DERL3 DERL2	5.87e-05	8	51	2	29743537
Pubmed	Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.	DERL3 DERL2	5.87e-05	8	51	2	26565908
Pubmed	The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.	DERL3 DERL2	7.54e-05	9	51	2	20435896
Pubmed	Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.	DERL3 DERL2	7.54e-05	9	51	2	18216283
Pubmed	Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation.	HOXA9 PKNOX1	7.54e-05	9	51	2	15087118
Pubmed	The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.	TAS2R31 TAS2R20	1.38e-04	12	51	2	12379855
Pubmed	Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape.	HOXA9 HOXC9	1.38e-04	12	51	2	27856734
Pubmed	Axial Hox9 activity establishes the posterior field in the developing forelimb.	HOXA9 HOXC9	1.38e-04	12	51	2	21383175
Pubmed	Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.	TAS2R31 TAS2R20	1.63e-04	13	51	2	15938754
Pubmed	Identification and characterization of human taste receptor genes belonging to the TAS2R family.	TAS2R31 TAS2R20	1.63e-04	13	51	2	12584440
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	DPYD CYP2F1 ABCB6 ABCG5	1.87e-04	193	51	4	19343046
Pubmed	Organization and expression of mouse Hox3 cluster genes.	HOXA9 HOXC9	1.90e-04	14	51	2	8099712
Pubmed	A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization.	HOXA9 HOXC9	2.50e-04	16	51	2	31747609
Pubmed	Hox genes and the evolution of vertebrate axial morphology.	HOXA9 HOXC9	2.50e-04	16	51	2	7768176
Pubmed	Hox patterning of the vertebrate rib cage.	HOXA9 HOXC9	2.83e-04	17	51	2	17626057
Pubmed	The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.	HNF1B PKD1	2.83e-04	17	51	2	16472605
Pubmed	Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.	HOXA9 HOXC9	3.18e-04	18	51	2	9639506
Pubmed	Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.	HOXA9 HOXC9	3.18e-04	18	51	2	9291463
Pubmed	Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK).	DERL3 DERL2	3.55e-04	19	51	2	25660456
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	GAPVD1 ATP6V0A1 MYO9A PKD1 TNFAIP3 DNAH14 EPB41L2	3.84e-04	925	51	7	28986522
Pubmed	Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.	HNF1B PKD1	3.94e-04	20	51	2	17251353
Pubmed	A novel family of mammalian taste receptors.	TAS2R31 TAS2R20	4.35e-04	21	51	2	10761934
Pubmed	Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.	HNF1B PKD1	4.35e-04	21	51	2	27591083
Pubmed	Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.	HNF1B PKD1	4.78e-04	22	51	2	27582005
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R31 TAS2R20	4.78e-04	22	51	2	12734386
Pubmed	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	DPYD FCGBP ABCG5	5.44e-04	108	51	3	19956635
Pubmed	Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.	HOXA9 HOXC9	5.70e-04	24	51	2	9367423
Pubmed	Receptors for bitter and sweet taste.	TAS2R31 TAS2R20	6.19e-04	25	51	2	12139982
Pubmed	Fine mapping of human HOX gene clusters.	HOXA9 HOXC9	6.70e-04	26	51	2	8646877
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R31 TAS2R20	6.70e-04	26	51	2	11696554
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	GAPVD1 NOXO1 PKD1 TAS2R31 DNAH14 EPB41L2	7.05e-04	736	51	6	29676528
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	ATP6V0A1 NUP155 MYO1D GNAS EPB41L2	7.09e-04	484	51	5	31995728
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R31 TAS2R20	7.23e-04	27	51	2	12581520
Pubmed	DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.	SFXN4 EPB41L2	7.78e-04	28	51	2	32937373
Pubmed	The human HOX gene family.	HOXA9 HOXC9	8.35e-04	29	51	2	2574852
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	TAS2R31 TAS2R20	8.93e-04	30	51	2	17273929
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R31 TAS2R20	8.93e-04	30	51	2	12679530
Pubmed	Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.	HOXA9 HOXC9	1.02e-03	32	51	2	17535249
Pubmed	Ndrg2 regulates vertebral specification in differentiating somites.	HOXA9 HOXC9	1.02e-03	32	51	2	22819676
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	HOXA9 HOXC9	1.02e-03	32	51	2	37167859
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R31 TAS2R20	1.15e-03	34	51	2	15496549
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ATP6V0A1 MYO1D ATP11C GNAS	1.15e-03	313	51	4	38270169
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	HOXA9 HOXC9 PKNOX1 NOTO LHX9	1.19e-03	544	51	5	28473536
Pubmed	Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.	HNF1B PKD1	1.29e-03	36	51	2	25715395
Pubmed	Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.	HNF1B PKD1	1.29e-03	36	51	2	33737325
Pubmed	Global control of motor neuron topography mediated by the repressive actions of a single hox gene.	HOXA9 HOXC9	1.29e-03	36	51	2	20826310
Pubmed	HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells.	SLC11A2 TNFAIP3	1.36e-03	37	51	2	24742347
Pubmed	Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.	PDILT GNAS	1.36e-03	37	51	2	22797727
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXA9 HOXC9	1.43e-03	38	51	2	15042701
Pubmed	Complete mutation analysis panel of the 39 human HOX genes.	HOXA9 HOXC9	1.43e-03	38	51	2	11857506
Cytoband	6q23	TNFAIP3 EPB41L2	1.44e-04	16	51	2	6q23
Cytoband	12p13.2	TAS2R31 TAS2R20	1.16e-03	45	51	2	12p13.2
Cytoband	16p13.3	NOXO1 PKD1 CAPN15	2.56e-03	244	51	3	16p13.3
GeneFamily	Rhomboid family	DERL3 DERL2	4.71e-04	14	42	2	926
GeneFamily	Taste 2 receptors	TAS2R31 TAS2R20	3.70e-03	39	42	2	1162
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP6 ARHGAP25	6.01e-03	50	42	2	721
GeneFamily	HOXL subclass homeoboxes	HOXA9 HOXC9	6.49e-03	52	42	2	518
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO1D MYO9A MARCHF1 DNAH14	7.57e-08	188	51	6	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A MARCHF1 DNAH14	2.62e-06	191	51	5	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	DPYD ARHGAP25 MARCHF1 TLR8 EPB41L2	3.13e-06	198	51	5	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	DPYD ARHGAP25 MARCHF1 TLR8 EPB41L2	3.13e-06	198	51	5	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	DPYD ARHGAP25 MARCHF1 TLR8 EPB41L2	3.13e-06	198	51	5	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	metastatic_Brain-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	HOXA9 HNF1B ACKR2 MARCHF1	3.46e-05	161	51	4	e6e294b4ba911c1327664f1a0f93207096c6de03
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADORA1 MAB21L3 HCAR1 DNAH14	3.46e-05	161	51	4	7c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell	Control-B_cells-Plasma_cells\|Control / group, cell type (main and fine annotations)	CFAP54 MYO1D DERL3 USP48	4.79e-05	175	51	4	fb23858cfce71509cafbe0d9728e678012ff2962
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A MARCHF1	4.90e-05	176	51	4	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B MYO1D MYO9A MARCHF1	5.01e-05	177	51	4	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGAP6 DPYD MYO1D DNAH14	5.23e-05	179	51	4	747a32460b257fffca30527b56a74720eb9c12e4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A MARCHF1	5.46e-05	181	51	4	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A MARCHF1	5.46e-05	181	51	4	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADORA1 DPYD HNF1B ABCB6	5.58e-05	182	51	4	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	COPD-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	CFAP54 MYO1D DERL3 USP48	5.58e-05	182	51	4	19db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADORA1 DPYD HNF1B ABCB6	5.58e-05	182	51	4	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADORA1 DPYD HNF1B ABCB6	5.58e-05	182	51	4	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFAP54 DERL3 ABCB6 DNAH14	5.70e-05	183	51	4	dd15e1463a0d57d14800de0df0645c81c56926ae
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFAP54 DERL3 ABCB6 DNAH14	5.70e-05	183	51	4	8ace19c38b89556d2504258a63aa5a2b14f5cd36
ToppCell	nucseq-Immune-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DERL3 ARHGAP25 USP48 MARCHF1	5.82e-05	184	51	4	911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DPYD MYO1D ANKRD30B DNAH14	5.82e-05	184	51	4	9a185e6ea86bbfbb48bfe88650a8c05ceba78d7f
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-club_cell-club_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPYD HNF1B FCGBP NOXO1	5.82e-05	184	51	4	204d16c48f822c98dc4118ac97a4f99f7e1163c8
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-club_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPYD HNF1B FCGBP NOXO1	5.82e-05	184	51	4	9365cdc52a2419e3f27e1c1c9310fa707d1e506b
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DERL3 ARHGAP25 USP48 MARCHF1	5.82e-05	184	51	4	942b58ae7172bb5f97e55b032db9329d161854af
ToppCell	droplet-Lung-nan-21m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD HNF1B FCGBP NOXO1	5.82e-05	184	51	4	7cc3b9bba1f600b40b02fe2456b5d007dbf9fa37
ToppCell	droplet-Lung-nan-21m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD HNF1B FCGBP NOXO1	5.82e-05	184	51	4	53b71c4ac86dc5e42763b8f64fbc917177531017
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP54 MYO1D DERL3 USP48	5.95e-05	185	51	4	3b77bc49cd3740acc025e162a36282ac09e12198
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A DNAH14	6.07e-05	186	51	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGBP DERL3 TNFAIP3 CAPN15	6.20e-05	187	51	4	59d28f4ee1d463ae20abb8d7e7399b504d80698a
ToppCell	Control-Myeloid-MoAM5\|Control / Disease group,lineage and cell class （2021.01.30）	FCGBP DERL3 TNFAIP3 CAPN15	6.20e-05	187	51	4	8769341be67382cea2a590d962f4def7c39de883
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGBP DERL3 TNFAIP3 CAPN15	6.20e-05	187	51	4	25adf648c05c21534b4913254e73d43fc5f64e06
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FCGBP DERL3 TNFAIP3 CAPN15	6.20e-05	187	51	4	3b0cfa9e5ea5e7d6dda689c328b9b5110b43ee1d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A DNAH14	6.20e-05	187	51	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1D ATP11C ST8SIA1 EPB41L2	6.20e-05	187	51	4	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B FCGBP MYO9A MARCHF1	6.20e-05	187	51	4	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1D ATP11C ST8SIA1 EPB41L2	6.20e-05	187	51	4	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FCGBP DERL3 TNFAIP3 CAPN15	6.20e-05	187	51	4	0d589de12108230ced5b60229564f4a181e2f172
ToppCell	ASK452-Immune-Mast_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	SLC11A2 ARHGAP25 TNFAIP3 ST8SIA1	6.33e-05	188	51	4	840215e16cff90f821f776186284eafcf2350690
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B MYO9A MARCHF1 DNAH14	6.46e-05	189	51	4	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HNF1B CFAP54 MYO9A DNAH14	6.59e-05	190	51	4	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	ASK452-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SLC11A2 ARHGAP25 TNFAIP3 ST8SIA1	6.87e-05	192	51	4	8269b88ff6073a908f547fcc7c5941f2e8289694
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ACKR2 ST8SIA1 GNAS EPB41L2	6.87e-05	192	51	4	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HNF1B CYP2F1 ANKRD30B ABCG5	7.01e-05	193	51	4	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 HNF1B MYO9A DNAH14	7.15e-05	194	51	4	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 HNF1B MYO9A DNAH14	7.29e-05	195	51	4	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 HNF1B MYO9A DNAH14	7.44e-05	196	51	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP6 HNF1B MYO9A DNAH14	7.44e-05	196	51	4	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	(1)_B_cell-(101)_plasma\|(1)_B_cell / immune cells in Peripheral Blood (logTPM normalization)	MYO1D DERL3 DERL2 ACKR2	7.58e-05	197	51	4	c86fcd779f30074bdf0b23d763fee5b7e4a6e4f5
ToppCell	(1)_B_cell-(10)_B_cell-(101)_plasma\|(10)_B_cell / immune cells in Peripheral Blood (logTPM normalization)	MYO1D DERL3 DERL2 ACKR2	7.58e-05	197	51	4	c7af5510e2dd69b6a044244b22e62b82f474fdbd
ToppCell	3'-GW_trimst-1-LargeIntestine\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA9 HOXC9 GNAS SNRPE	7.73e-05	198	51	4	ea6621a148a96c8ffa1a93a35c9e288545d2637a
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGBP DERL3 MARCHF1 EPB41L2	8.04e-05	200	51	4	a1503bcc774bed9563eda7cf90b8b5bf4405ad85
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FCGBP NOXO1 DERL3 GNAS	8.04e-05	200	51	4	e9908b6cba21a59023cf8d0f98fbd1d1f7de6b44
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGBP DERL3 MARCHF1 EPB41L2	8.04e-05	200	51	4	25247f8b6ba6cd899ba6bd47e28e090d697e4632
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DPYD MYO1D MARCHF1 EPB41L2	8.04e-05	200	51	4	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)--\|Striatum / BrainAtlas - Mouse McCarroll V32	HOXA9 MAB21L3 ABCG5	9.46e-05	77	51	3	7bb18406d404c51ee938cc577c155dc51868ddb9
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)\|Striatum / BrainAtlas - Mouse McCarroll V32	HOXA9 MAB21L3 ABCG5	9.46e-05	77	51	3	ac311740424ff75b478b3c19fa0fae93776eb54e
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	HOXA9 MAB21L3 ABCG5	9.46e-05	77	51	3	9f2dbf922acb905d636427a766a217c0db9671d2
ToppCell	ILEUM-non-inflamed-(5)_Plasma-(5)_IgA_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DERL3 ACKR2	1.69e-04	17	51	2	e6cf84476cc6f32a090c8bdabe02fa516d411360
Disease	Colorectal Carcinoma	ADORA1 DPYD HOXC9 SLC11A2 PDILT PKNOX1 ABCB6 ATP11C GNAS	1.41e-06	702	47	9	C0009402
Disease	pars triangularis volume measurement	MARCHF1 EPB41L2	4.63e-04	20	47	2	EFO_0010321
Disease	frontotemporal dementia	HNF1B CFAP54	1.19e-03	32	47	2	MONDO_0017276

Protein segments in the cluster

Peptide	Gene	Start	Entry
WKLFLRFQQNLLGFL	ACKR2	206	O00590
RALWNFTQELQILLK	CFAP54	1641	Q96N23
LESKNRWLRQQLVYA	ANKRD30B	1306	Q9BXX2
RIQKFRVTFLKIWND	ADORA1	291	P30542
VSNLRTFLWIRVQQF	ABCB6	326	Q9NP58
RWVRQAVQIPFFAKL	DPYD	696	Q12882
HLVFRKFQVWRLVTN	DERL3	46	Q96Q80
QSIIRFWLQNLRAKQ	ANO8	166	Q9HCE9
WKVLRQFSIQILRNF	CYP2F1	121	P24903
LFSQAQRKQLWVALI	CAPN15	611	O75808
ARVLNLTERQVKIWF	HOXC9	226	P31274
LYRTAWIAKQQRINL	GAPVD1	41	Q14C86
NLVTLFLFVVWQIQR	C9orf131	41	Q5VYM1
RQLRNLPWLFTFNVK	EPB41L2	281	O43491
LTKRVLQVWFQNARA	LHX9	306	Q9NQ69
RLLNLTERQVKIWFQ	HOXA9	241	P31269
ARLKLTENQVRVWFQ	NOTO	191	A8MTQ0
FLNLKWSRFARVVLT	SLC11A2	401	P49281
VFHFWIRLVQILQKG	GARIN1B	186	Q96KD3
WRRLKAYNRVIFVQN	MARCHF1	226	Q8TCQ1
WQVFSKAFLRLVRKL	MAB21L3	301	Q8N8X9
IQQLVRKSYQALALW	NUP155	781	O75694
IFASPRRWLQQRKFQ	ARHGAP6	166	O43182
VANFTLRLEQRQWKV	FCGBP	2516	Q9Y6R7
RQQWTRQILKDVSLY	ABCG5	61	Q9H222
LIQRLNFFNTWAKVA	DNAH14	3266	Q0VDD8
WLKRGLRFIQVFLQS	GLTP	96	Q9NZD2
SFKIVWSLRRRQQLA	HCAR1	196	Q9BXC0
ELIFKHFQIWRLITN	DERL2	46	Q9GZP9
KQRIQNLSRFVWKQA	DRP2	191	Q13474
KAAQQLRFVRQWSVF	PKD1	4001	P98161
WYVRKQREILRQFNQ	HNF1B	171	P35680
VWLRRQISQKAFLFN	PDILT	146	Q8N807
FIALINFIAWVKRQK	TAS2R20	26	P59543
LKQTFLSVLRQVRYW	TAS2R31	286	P59538
RQSFIRRFLQWTELL	SFXN4	36	Q6P4A7
LTLLQVNNWFINARR	PKNOX1	301	P55347
NNRWLRTISVILFLN	GNAS	921	Q5JWF2
IIRQRFQNLLWSRKT	ST8SIA1	191	Q92185
VQIKRLQTFAFSVRW	NOXO1	16	Q8NFA2
WNFLPKNLFEQFRRI	ATP11C	56	Q8NB49
VTLNLFLQINRKDLW	NLRP9	71	Q7RTR0
LKFFNWTLLQQFPRL	TLR8	676	Q9NR97
RNFKFRWQLESLKSQ	TNFAIP3	136	P21580
QRSIVKNWQQRYFVL	ARHGAP25	56	P42331
IFRYLQNRSRIQVWL	SNRPE	21	P62304
RVLQAAAKNIRVWFI	ATP6V0A1	281	Q93050
RLQQLFKGSQFAIRW	TOMM7	11	Q9P0U1
NIVFTIKINIWLRVF	SMAD5-AS1	26	Q9Y6J3
NTFLQVWFLNLELRQ	USP48	101	Q86UV5
LQTIFNRWRASQLIK	MYO1D	776	O94832
SVIIQRFWRNYLNQK	MYO9A	1046	B2RTY4