Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloendopeptidase activity	PHEX MBTPS1 ADAMTS16 MMP8 MMP12	1.21e-04	120	80	5	GO:0004222
GeneOntologyMolecularFunction	piRNA binding	PIWIL4 PIWIL3	2.35e-04	6	80	2	GO:0034584
GeneOntologyMolecularFunction	endopeptidase activity	PHEX HGF MBTPS1 USP9X ADAMTS16 NLRP1 MMP8 MMP12	3.24e-04	430	80	8	GO:0004175
MousePheno	abnormal pelvic girdle joint morphology	PHEX COMP IDUA	7.54e-06	9	64	3	MP:0030819
MousePheno	abnormal hip joint morphology	PHEX COMP IDUA	7.54e-06	9	64	3	MP:0030829
MousePheno	abnormal girdle joint morphology	PHEX COMP IDUA	3.21e-05	14	64	3	MP:0030818
MousePheno	abnormal hindlimb joint morphology	PHEX COMP IDUA	9.87e-05	20	64	3	MP:0030808
MousePheno	spiral ligament degeneration	HGF IDUA	1.23e-04	4	64	2	MP:0004864
Domain	Thbs/COMP_coiled-coil	THBS3 THBS4 COMP	7.57e-08	3	80	3	IPR024665
Domain	COMP	THBS3 THBS4 COMP	7.57e-08	3	80	3	PF11598
Domain	TSP_3	THBS3 THBS4 COMP	7.52e-07	5	80	3	PF02412
Domain	TSP3	THBS3 THBS4 COMP	7.52e-07	5	80	3	PS51234
Domain	TSP_CTER	THBS3 THBS4 COMP	7.52e-07	5	80	3	PS51236
Domain	-	THBS3 THBS4 COMP	7.52e-07	5	80	3	4.10.1080.10
Domain	Thrombospondin_C	THBS3 THBS4 COMP	7.52e-07	5	80	3	IPR008859
Domain	TSP_C	THBS3 THBS4 COMP	7.52e-07	5	80	3	PF05735
Domain	Thrombospondin_3_rpt	THBS3 THBS4 COMP	7.52e-07	5	80	3	IPR017897
Domain	Thrombospondin_3-like_rpt	THBS3 THBS4 COMP	7.52e-07	5	80	3	IPR003367
Domain	TSP_type-3_rpt	THBS3 THBS4 COMP	7.52e-07	5	80	3	IPR028974
Domain	Ion_trans_dom	TRPM6 CACNA1F SCN11A KCNQ5 CNGA1	1.30e-04	114	80	5	IPR005821
Domain	Ion_trans	TRPM6 CACNA1F SCN11A KCNQ5 CNGA1	1.30e-04	114	80	5	PF00520
Domain	MetalloPept_cat_dom	PHEX ADAMTS16 MMP8 MMP12	4.04e-04	81	80	4	IPR024079
Domain	-	PHEX ADAMTS16 MMP8 MMP12	4.04e-04	81	80	4	3.40.390.10
Domain	PIWI	PIWIL4 PIWIL3	4.99e-04	8	80	2	PS50822
Domain	Piwi	PIWIL4 PIWIL3	4.99e-04	8	80	2	SM00950
Domain	Piwi	PIWIL4 PIWIL3	4.99e-04	8	80	2	IPR003165
Domain	Piwi	PIWIL4 PIWIL3	4.99e-04	8	80	2	PF02171
Domain	PAZ	PIWIL4 PIWIL3	6.40e-04	9	80	2	PS50821
Domain	PAZ	PIWIL4 PIWIL3	6.40e-04	9	80	2	SM00949
Domain	PAZ_dom	PIWIL4 PIWIL3	6.40e-04	9	80	2	IPR003100
Domain	PAZ	PIWIL4 PIWIL3	6.40e-04	9	80	2	PF02170
Domain	CYSTEINE_SWITCH	ADAMTS16 MMP8 MMP12	7.17e-04	41	80	3	PS00546
Domain	Pept_M10_metallopeptidase	ADAMTS16 MMP8 MMP12	8.25e-04	43	80	3	IPR001818
Domain	ZINC_PROTEASE	PHEX ADAMTS16 MMP8 MMP12	8.31e-04	98	80	4	PS00142
Domain	IMPORTIN_B_NT	XPO1 IPO11	1.59e-03	14	80	2	PS50166
Domain	Pept_M10A_Zn_BS	MMP8 MMP12	1.83e-03	15	80	2	IPR021158
Domain	IBN_N	XPO1 IPO11	1.83e-03	15	80	2	PF03810
Domain	IBN_N	XPO1 IPO11	2.09e-03	16	80	2	SM00913
Domain	Hemopexin_CS	MMP8 MMP12	2.36e-03	17	80	2	IPR018486
Domain	Importin-beta_N	XPO1 IPO11	2.36e-03	17	80	2	IPR001494
Domain	Pept_M10A_stromelysin-type	MMP8 MMP12	2.65e-03	18	80	2	IPR016293
Domain	PG_binding_1	MMP8 MMP12	3.27e-03	20	80	2	PF01471
Domain	Peptidoglycan-bd-like	MMP8 MMP12	3.27e-03	20	80	2	IPR002477
Domain	Hemopexin-like_dom	MMP8 MMP12	4.32e-03	23	80	2	IPR000585
Domain	TSPN	THBS3 THBS4	4.32e-03	23	80	2	SM00210
Domain	Hemopexin-like_repeat	MMP8 MMP12	4.32e-03	23	80	2	IPR018487
Domain	M10A_MMP	MMP8 MMP12	4.32e-03	23	80	2	IPR033739
Domain	Hemopexin	MMP8 MMP12	4.32e-03	23	80	2	PF00045
Domain	HEMOPEXIN	MMP8 MMP12	4.32e-03	23	80	2	PS00024
Domain	-	MMP8 MMP12	4.32e-03	23	80	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP8 MMP12	4.32e-03	23	80	2	PS51642
Pubmed	Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.	THBS3 THBS4 COMP	1.26e-08	3	82	3	33910854
Pubmed	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.	THBS3 THBS4 COMP	1.26e-07	5	82	3	30622267
Pubmed	Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.	THBS3 THBS4 COMP	1.26e-07	5	82	3	18467703
Pubmed	Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.	THBS3 THBS4 COMP	7.01e-07	8	82	3	24460873
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	KAT5 HDAC6 GTF3C1 PTCD1 DNAAF10 USP9X GYG1 WDR87 RECQL4 SF3A3 PCNX1 CHD3 XPO1 LANCL2	2.70e-06	1335	82	14	29229926
Pubmed	Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.	GRAPL GRAP	5.49e-06	2	82	2	19836472
Pubmed	Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.	GRAPL GRAP	5.49e-06	2	82	2	11971956
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	5.49e-06	2	82	2	12895410
Pubmed	Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4.	THBS3 THBS4	5.49e-06	2	82	2	11137453
Pubmed	COMP and TSP-4 interact specifically with the novel GXKGHR motif only found in fibrillar collagens.	THBS4 COMP	5.49e-06	2	82	2	30464261
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	5.49e-06	2	82	2	8922996
Pubmed	Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.	GRAPL GRAP	5.49e-06	2	82	2	15174222
Pubmed	A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2.	BRCA2 XPO1	5.49e-06	2	82	2	18059333
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	5.49e-06	2	82	2	12925892
Pubmed	Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis.	GRAPL GRAP	5.49e-06	2	82	2	37343720
Pubmed	TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.	KAT5 TRIM68	1.64e-05	3	82	2	18451177
Pubmed	The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing.	HGF ARF6	1.64e-05	3	82	2	28429746
Pubmed	HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.	HGF ARF6	1.64e-05	3	82	2	30404949
Pubmed	Hepatocyte growth factor attenuates high glucose-disturbed mitochondrial dynamics in podocytes by decreasing ARF6-dependent DRP1 translocation.	HGF ARF6	1.64e-05	3	82	2	37913847
Pubmed	Regulatory expression of MMP-8/MMP-9 and inhibition of proliferation, migration and invasion in human lung cancer A549 cells in the presence of HGF variants.	HGF MMP8	1.64e-05	3	82	2	24099107
Pubmed	Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.	MMP8 MMP12	1.64e-05	3	82	2	33902302
Pubmed	Faster regeneration associated to high expression of Fam65b and Hdac6 in dysferlin-deficient mouse.	HDAC6 DYSF	1.64e-05	3	82	2	31218594
Pubmed	Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer.	HDAC6 XPO1	1.64e-05	3	82	2	22334690
Pubmed	Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.	PLAAT1 BRCA2 XPO1	2.47e-05	24	82	3	26178733
Pubmed	Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.	THBS3 THBS4	3.28e-05	4	82	2	6338048
Pubmed	Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway.	KAT5 BRCA2	3.28e-05	4	82	2	18263878
Pubmed	TNF stimulates nuclear export and secretion of IL-15 by acting on CRM1 and ARF6.	XPO1 ARF6	3.28e-05	4	82	2	23950892
Pubmed	Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.	PIWIL4 PIWIL3	3.28e-05	4	82	2	28025795
Pubmed	Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.	PIWIL4 PIWIL3	3.28e-05	4	82	2	20940137
Pubmed	Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.	HGF ARF6	3.28e-05	4	82	2	16880525
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	GTF3C1 GLB1 USP9X SNX18 SF3A3 CHD3 USP9Y IPO11	3.81e-05	533	82	8	25544563
Pubmed	Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.	GRAPL GRAP	5.47e-05	5	82	2	30610177
Pubmed	A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization.	BRCA2 XPO1	5.47e-05	5	82	2	24013206
Pubmed	Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.	HDAC6 DYSF	5.47e-05	5	82	2	24687993
Pubmed	Matrix metalloproteinase polymorphisms and bladder cancer risk.	MMP8 MMP12	8.19e-05	6	82	2	17178858
Pubmed	Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress.	KAT5 HDAC6	8.19e-05	6	82	2	31857589
Pubmed	Matrix metalloproteinase activity in pediatric acute lung injury.	MMP8 MMP12	8.19e-05	6	82	2	19159011
Pubmed	Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.	MMP8 MMP12	8.19e-05	6	82	2	17473191
Pubmed	Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.	IFNGR2 MMP8 MMP12	8.53e-05	36	82	3	20587546
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP8 MMP12	1.14e-04	7	82	2	8921407
Pubmed	Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.	GRAPL GRAP	1.14e-04	7	82	2	15456754
Pubmed	Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.	MMP8 MMP12	1.14e-04	7	82	2	10859319
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP8 MMP12	1.14e-04	7	82	2	11113146
Pubmed	The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.	L1CAM MOG	1.52e-04	8	82	2	25953347
Pubmed	TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.	NLRP1 TRIM68	1.52e-04	8	82	2	24999993
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CRNKL1 GTF3C1 USP9X XPO1 USP9Y DYSF IPO11	1.76e-04	497	82	7	36774506
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	HDAC6 BRCA2 CHD3	1.78e-04	46	82	3	30419336
Pubmed	Identification of eight members of the Argonaute family in the human genome.	PIWIL4 PIWIL3	1.96e-04	9	82	2	12906857
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	GTF3C1 BRCA2 XPO1 ARF6	2.24e-04	125	82	4	21654808
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CRNKL1 KAT5 HDAC6 WIZ GTF3C1 HECTD4 SF3A3 XPO1 USP9Y SIPA1L2	2.29e-04	1082	82	10	38697112
Pubmed	Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.	GTF3C1 ABT1	2.44e-04	10	82	2	19299493
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	2.44e-04	10	82	2	9384609
Pubmed	Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.	MMP8 MMP12	2.98e-04	11	82	2	37312667
Pubmed	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.	KAT5 BRCA2	2.98e-04	11	82	2	18406329
Pubmed	Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.	SLC18A3 L1CAM	2.98e-04	11	82	2	10521398
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP8 MMP12	2.98e-04	11	82	2	10949161
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	CRNKL1 MBTPS1 KAT5 HDAC6 WIZ GTF3C1 GLB1 ENTPD6 ZFP28 CHD3	3.10e-04	1124	82	10	21900206
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9X USP9Y	3.57e-04	12	82	2	23861879
Pubmed	Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).	MAGED4 USP9X	3.57e-04	12	82	2	22544753
Pubmed	A role for Nr-CAM in the patterning of binocular visual pathways.	L1CAM CNTN3	3.57e-04	12	82	2	16701205
Pubmed	Blimp1 regulates the transition of neonatal to adult intestinal epithelium.	GLB1 PRDM1	4.21e-04	13	82	2	21878906
Pubmed	Pioneering axons regulate neuronal polarization in the developing cerebral cortex.	L1CAM CNTN3	4.21e-04	13	82	2	24559674
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	HGF KAT5 WIZ BRCA2	4.37e-04	149	82	4	25184681
Pubmed	Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.	KAT5 CHD3	4.91e-04	14	82	2	16455055
Pubmed	Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.	MMP8 MMP12	4.91e-04	14	82	2	16236725
Pubmed	Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.	MMP8 MMP12	4.91e-04	14	82	2	25636537
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9X USP9Y	5.65e-04	15	82	2	9827704
Pubmed	Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).	SNX18 GRAP	5.65e-04	15	82	2	25036101
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	USP9X USP9Y	5.65e-04	15	82	2	14762062
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP8 MMP12	6.45e-04	16	82	2	20484597
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP8 MMP12	6.45e-04	16	82	2	10949577
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP8 MMP12	6.45e-04	16	82	2	37701782
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	HDAC6 DNAAF10 USP9X SNX18 SIPA1L2 IPO11	6.62e-04	446	82	6	24255178
Pubmed	Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.	MMP8 MMP12	7.30e-04	17	82	2	27398409
Pubmed	A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.	ACOT8 DNAAF9	7.30e-04	17	82	2	11549316
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP9X USP9Y	7.30e-04	17	82	2	23287719
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	CRNKL1 DNAAF10 USP9X SF3A3 IPO11	7.33e-04	300	82	5	28561026
Pubmed	Deletion of STK40 protein in mice causes respiratory failure and death at birth.	HGF TTF1	8.20e-04	18	82	2	23293024
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9X USP9Y	8.20e-04	18	82	2	12023983
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CRNKL1 WIZ GTF3C1 SF3A3 ABT1 CHD3 XPO1 NDUFB5	8.72e-04	847	82	8	35850772
Pubmed	A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.	MMP8 MMP12	9.15e-04	19	82	2	24784232
Pubmed	ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.	MMP8 MMP12	9.15e-04	19	82	2	22014525
Pubmed	Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.	MMP8 MMP12	9.15e-04	19	82	2	15063736
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	HGD THBS4 COMP GLB1 SNX18 STEAP4 IDUA DYSF ARF6	9.37e-04	1070	82	9	23533145
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	USP9X XPO1 LANCL2 IPO11	9.42e-04	183	82	4	23956138
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	IFNGR2 THBS4 MMP8 MMP12	1.00e-03	186	82	4	20673868
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	IFNGR2 THBS4 MMP8 MMP12	1.00e-03	186	82	4	20452482
Pubmed	Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.	L1CAM LANCL2 MOG	1.05e-03	84	82	3	19165527
Pubmed	The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes.	GLB1 PRDM1	1.12e-03	21	82	2	21670299
Pubmed	Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling.	GTF3C1 IPO11	1.12e-03	21	82	2	19725029
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	BRCA2 XPO1 USP9Y	1.16e-03	87	82	3	17148452
Pubmed	Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.	MBTPS1 COMP	1.23e-03	22	82	2	25147951
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP8 MMP12	1.23e-03	22	82	2	23421805
Pubmed	Matrix metalloproteinases.	MMP8 MMP12	1.23e-03	22	82	2	10419448
Pubmed	Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.	CHST10 KCNQ5 DNAAF10 SNX18	1.26e-03	198	82	4	27480124
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	CRNKL1 WIZ GTF3C1 CHD3 IPO11	1.30e-03	341	82	5	32971831
Pubmed	MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.	KAT5 BRCA2	1.35e-03	23	82	2	20332121
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP8 MMP12	1.47e-03	24	82	2	15734845
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	THBS3 THBS4 COMP ADAMTS16	1.56e-03	210	82	4	16537572
Pubmed	Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.	BRCA2 L1CAM	1.59e-03	25	82	2	32737294
GeneFamily	Argonaute/PIWI family	PIWIL4 PIWIL3	3.20e-04	8	62	2	408
ToppCell	Club_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	THBS4 WIZ STEAP4 CNTN3 SLC13A3 CNGA1	3.37e-07	147	83	6	9211242a8e40d50414d310940616eccce299a7f8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNQ5 WDR87 NLRP1 RXFP1 DYSF PRDM1	5.34e-07	159	83	6	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|Mesenchymal_cells / Lineage and Cell class	THBS4 PLAAT1 KCNQ5 COMP COLGALT2 DYSF	1.76e-06	195	83	6	b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 ADAMTS16 ANKLE1 B4GALNT3 ABCA10	6.49e-06	140	83	5	5e81fa3a19d23f0e9cae3878431ca1f78dff7238
ToppCell	COVID-19-APC-like-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	CRNKL1 DNAAF10 GYG1 PIWIL4 LANCL2	1.52e-05	167	83	5	854a5dbd43f2b25825a71d37fd7779507783a99a
ToppCell	healthy_donor-Myeloid-Monocytic-Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	TRPM6 PLAAT1 AOC3 STEAP4 DYSF	1.57e-05	168	83	5	04259f5a9b067cd1b5619e34591e4b2fccc18535
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGF KCNQ5 L1CAM CHD3 LANCL2	1.96e-05	176	83	5	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	THBS4 GRAPL DYSF IPO11 GRAP	2.25e-05	181	83	5	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	THBS4 GRAPL DYSF IPO11 GRAP	2.25e-05	181	83	5	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 GRAPL DYSF GRAP PRDM1	2.37e-05	183	83	5	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 GRAPL DYSF GRAP PRDM1	2.37e-05	183	83	5	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	Control-Myeloid-MoAM1\|Control / Disease group,lineage and cell class （2021.01.30）	HGF COLGALT2 MMP12 DYSF PRDM1	2.76e-05	189	83	5	55d5c2fb9e6ab556d42c83a1e985ee66e4cf9dba
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HGF COLGALT2 MMP12 DYSF PRDM1	2.76e-05	189	83	5	ebb5e069fdca7cf8ffac16a57572e92d2593c86a
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HGF COLGALT2 MMP12 DYSF PRDM1	2.76e-05	189	83	5	a59e4eaff430a443f9fa7edabe64e66a15b6bffb
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HGF COLGALT2 MMP12 DYSF PRDM1	2.83e-05	190	83	5	5c8aa310886c64ee5dce4ba46a3dd178da549529
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HGF COLGALT2 MMP12 DYSF PRDM1	2.83e-05	190	83	5	4b4fe93061c87605dddf5bec94fa07c749c722aa
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)\|Striatum / BrainAtlas - Mouse McCarroll V32	CACNA1F COMP AOC3 STEAP4	3.14e-05	96	83	4	d98df92856840602a82d3f050bf0a1543445cac0
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Ccnd1_(Mural.Rgs5Acta2.Ccnd1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	CACNA1F COMP AOC3 STEAP4	3.14e-05	96	83	4	bf62c29da66aa3eefdc59337dfb3cd0467f04f10
ToppCell	COVID_vent-Myeloid-Monocytic-Developing_Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TRPM6 PIWIL4 B4GALNT3 MMP8 DYSF	3.21e-05	195	83	5	de23409b1b4146b8ae286850b829ec8dceed0117
Drug	chondroitin sulfate	HGF CHST10 THBS3 THBS4 COMP GLB1 L1CAM ADAMTS16 B4GALNT3 MMP8 IDUA MOG	2.85e-08	413	82	12	CID000024766
Disease	Oligospermia	PIWIL4 PIWIL3	4.83e-04	12	81	2	C0028960
Disease	Spastic Paraplegia, Hereditary	L1CAM CYP2U1	6.63e-04	14	81	2	C0037773
Disease	thoracic aortic aneurysm (is_marker_for)	MMP8 MMP12	6.63e-04	14	81	2	DOID:14004 (is_marker_for)
Disease	Myasthenic Syndromes, Congenital, Slow Channel	DPAGT1 SLC18A3	8.71e-04	16	81	2	C0751885
Disease	rheumatoid arthritis (is_marker_for)	HGF MMP8 CCL22	9.16e-04	69	81	3	DOID:7148 (is_marker_for)
Disease	Congenital Myasthenic Syndromes, Postsynaptic	DPAGT1 SLC18A3	9.85e-04	17	81	2	C0751883
Disease	Congenital Myasthenic Syndromes, Presynaptic	DPAGT1 SLC18A3	1.23e-03	19	81	2	C0751884
Disease	small cell lung carcinoma	BRCA2 PIWIL4 ABT1	1.41e-03	80	81	3	EFO_0000702
Disease	Arthrogryposis	SLC18A3 L1CAM	1.51e-03	21	81	2	C0003886
Disease	vitiligo (is_implicated_in)	HGF NLRP1	1.51e-03	21	81	2	DOID:12306 (is_implicated_in)
Disease	otitis media (implicated_via_orthology)	PHEX IDUA	1.66e-03	22	81	2	DOID:10754 (implicated_via_orthology)
Disease	Myasthenic Syndromes, Congenital	DPAGT1 SLC18A3	1.98e-03	24	81	2	C0751882

Protein segments in the cluster

Peptide	Gene	Start	Entry
HIGRNIARPWKLIYY	TTF1	591	Q15361
LFRGRHYWVPAKRLF	ACOT8	41	O14734
VRYRLPLRVVKHFYW	CCL22	41	O00626
YVGKGTRARPYVHLW	ANKLE1	486	Q8NAG6
YRLKFNWGYRIPVIK	ABCA10	46	Q8WWZ4
PKWTNYGLRIFGYLH	B4GALNT3	161	Q6L9W6
SYRWFLQHRPQVGYI	COMP	681	P49747
NYIRVKPHPWYSGRI	GRAPL	51	Q8TC17
NYIRVKPHPWYSGRI	GRAP	51	Q13588
YWQMVRPFLKPGYRH	CFAP46	136	Q8IYW2
NSRRFRGRHYKWKPY	ADAMTS16	656	Q8TE57
PARWTIQKVFYQGRY	AOC3	256	Q16853
LFFKDRYFWRRHPQL	MMP8	296	P22894
YGEALHRILGYRWKI	MSANTD5	116	A0A3B3IT52
GPVWRKHYITYRINN	MMP12	106	P39900
WNKYQPLDHVRRYFG	ANO7	326	Q6IWH7
RRYIPKNPHQYRVWA	CACNA1F	1171	O60840
IYVVQRRWNYGIHPS	ANOS1	216	P23352
RIPFAFWARYHQYIL	MAGED4	671	Q96JG8
KRVLWDQYHNLRYPP	MBTPS1	621	Q14703
LAVLYFKHGIDRYWR	IPO11	61	Q9UI26
YNVLERPRGWAFIYH	KCNQ5	116	Q9NR82
ELGRHRLKPWYFSPY	KAT5	236	Q92993
ERCPLLYQWHRKQYV	LANCL2	246	Q9NS86
HYSRVPRFYWKDRLL	GLB1	56	P16278
AGGLHLWKYEYPIQR	DNAAF10	281	Q96MX6
LGLLYHNWYPSRVFV	DPAGT1	236	Q9H3H5
AAQKVKHYYRFWILP	PCNX1	966	Q96RV3
KHYYRFWILPQLWIG	PCNX1	971	Q96RV3
NLYRVHFPVAGSYRW	NLRP1	1096	Q9C000
VKGHLRGYNVTYWRE	L1CAM	841	P32004
NRPGIFVRVAYYAKW	HGF	701	P14210
YKAPWARVLVYGLGH	HECTD4	2611	Q9Y4D8
VGWYRPPFSRVVHLY	MOG	66	Q16653
VFAHYGPVWRQQRKF	CYP2U1	166	Q7Z449
SPFRYDLWNLKYLHR	ABT1	136	Q9ULW3
VPPIQEKRHWKRYIY	CRNKL1	521	Q9BZJ0
VHFLGRVKPWNYTYD	GYG1	211	P46976
DPKLISRIWVYNHYR	BRCA2	2611	P51587
YYRFGIKPEWMTVHR	CHD3	621	Q12873
PVNFRYLLPYVAHWR	DNAAF9	111	Q5TEA3
RRYIGRYGLAHVSKW	IDUA	161	P35475
LKYRGLIKYWFHTPP	IFNGR2	271	P38484
LYFSIHRYEQGRFWP	HDAC6	271	Q9UBN7
LKNVQRLYHYVEWRP	COLGALT2	106	Q8IYK4
HFRVISRPQWVAYKY	PIWIL3	131	Q7Z3Z3
YRRNIWKGFLISIPY	SLC13A3	226	Q8WWT9
GTIYREPRHAYLRKW	DYSF	306	O75923
NVARGRLTYYAKPHW	CNTN3	306	Q9P232
RWGVADKTFRPPYYH	HGD	321	Q93099
ASRLQYYVPRGFWKQ	USP9X	1656	Q93008
VRLAARYPHLQWLYG	SLC18A3	346	Q16572
VGVFIYVAYIKWHRA	ENTPD6	51	O75354
VYGQDRRFWRKYLHL	RECQL4	1176	O94761
RLTFKLCHLYYNWPG	PIWIL4	801	Q7Z3Z4
YKYRFVPWIALNLSH	SETD9	16	Q8NE22
PYHRQGAVNKYVIGW	SIPA1L2	1386	Q9P2F8
NRKYFWRIYSRGELH	PRDM1	131	O75626
WIKHRPQKVGAYRSY	WIZ	1441	O95785
VRQLWHEGPQYFYRG	SLC25A53	66	Q5H9E4
YQKRLRFYWRPHCRG	PLA2G2D	126	Q9UNK4
GQDKIRPLWRHYYTG	ARF6	66	P62330
RPLWRHYYTGTQGLI	ARF6	71	P62330
PWYRHEIAPGIIRKY	CHST10	211	O43529
YFKLGWNYPEIRLNR	CNGA1	256	P29973
YRWFLQHRPQVGYIR	THBS4	881	P35443
LIRHWRYYHTGEKPF	ZFP28	491	Q8NHY6
YIVGQYPRFLRAHWK	XPO1	546	O14980
YLSPHYGFWVIRLRK	TRIM68	386	Q6AZZ1
GHQHLPWTRKVYEFY	TRPM6	821	Q9BX84
QVPVHRRYKHFDWLY	SNX18	306	Q96RF0
WGHPKYTCLYRFRVH	SUN3	336	Q8TAQ9
EYYKHPISRWIARNF	NDUFB5	111	O43674
YGVYPWLRHNVDLKL	PHEX	101	P78562
RPFKEMIHRFWYNYR	RXFP1	686	Q9HBX9
YRGTKYRRFPDWLDH	STEAP4	271	Q687X5
LQYYVPRGFWKQFRL	USP9Y	1661	O00507
SYRWQLLHRPQVGYI	THBS3	876	P49746
IEVFRPGYQHWALYL	PLAAT1	21	Q9HDD0
LDPYHYFRRGWNIFD	SCN11A	631	Q9UI33
YRGPKAFQRHFAEWR	SF3A3	416	Q12874
KLWRRPITGTHLYQY	STARD7	151	Q9NQZ5
AWLRRGLYYLKAGQH	TTC37	566	Q6PGP7
GRRNTPYWYFLQCKH	PTCD1	131	O75127
RVVHMFLWYLIYGHP	GTF3C1	801	Q12789
ILRYYFGHGREWLFA	WDR87	766	Q6ZQQ6