Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

5.25e-122794011GO:0005096
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.02e-095074011GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.02e-095074011GO:0030695
GeneOntologyMolecularFunctionenzyme activator activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

4.30e-086564011GO:0008047
GeneOntologyMolecularFunctionmolecular function activator activity

WNT5B TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G INHA TBC1D3C TBC1D3B TBC1D3K TBC1D3F

4.47e-0712334013GO:0140677
GeneOntologyMolecularFunction4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

FUT5 FUT6

5.84e-056402GO:0017083
GeneOntologyMolecularFunctionenzyme regulator activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

7.54e-0514184011GO:0030234
GeneOntologyMolecularFunctionalpha-(1->3)-fucosyltransferase activity

FUT5 FUT6

1.09e-048402GO:0046920
GeneOntologyMolecularFunctionfucosyltransferase activity

FUT5 FUT6

3.51e-0414402GO:0008417
GeneOntologyBiologicalProcessactivation of GTPase activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.09e-161094011GO:0090630
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

8.66e-132444011GO:0043547
GeneOntologyBiologicalProcessregulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.68e-113354011GO:0043087
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.83e-094994011GO:0051345
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

TBC1D3E ABL1 TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.37e-0710284012GO:0043085
GeneOntologyBiologicalProcessregulation of hydrolase activity

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

5.81e-078784011GO:0051336
GeneOntologyBiologicalProcesspositive regulation of molecular function

TBC1D3E ABL1 TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.06e-0514304012GO:0044093
GeneOntologyBiologicalProcessfucose catabolic process

FUT5 FUT6

1.31e-049402GO:0019317
GeneOntologyBiologicalProcessL-fucose catabolic process

FUT5 FUT6

1.31e-049402GO:0042355
GeneOntologyBiologicalProcessL-fucose metabolic process

FUT5 FUT6

1.63e-0410402GO:0042354
GeneOntologyBiologicalProcessoligosaccharide metabolic process

SI FUT5 FUT6

3.38e-0470403GO:0009311
DomainTBC

TBC1D3E TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.48e-18493910SM00164
DomainRabGAP-TBC

TBC1D3E TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

8.22e-18533910PF00566
DomainTBC_RABGAP

TBC1D3E TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.23e-17553910PS50086
DomainRab-GTPase-TBC_dom

TBC1D3E TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.23e-17553910IPR000195
DomainGlyco_transf_10

FUT5 FUT6

1.18e-048392PF00852
DomainGlyco_tran_10_N

FUT5 FUT6

1.18e-048392PF17039
DomainGlyco_trans_10

FUT5 FUT6

1.18e-048392IPR001503
DomainGlyco_tran_10_N

FUT5 FUT6

1.18e-048392IPR031481
Domainp53-like_TF_DNA-bd

FUT5 FUT6

5.47e-0353392IPR008967
PathwayWP_17Q12_COPY_NUMBER_VARIATION_SYNDROME

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K

3.63e-1399309M46448
PathwayREACTOME_BLOOD_GROUP_SYSTEMS_BIOSYNTHESIS

FUT5 FUT6 RHCE

1.13e-0521303M27917
PathwayKEGG_MEDICUS_REFERENCE_LEWIS_X_ANTIGEN_BIOSYNTHESIS

FUT5 FUT6

4.36e-055302M47966
PathwayKEGG_MEDICUS_REFERENCE_SIALYL_LEWIS_X_ANTIGEN_BIOSYNTHESIS

FUT5 FUT6

6.53e-056302M47967
PathwayBIOCARTA_AMAN_PATHWAY

FUT5 FUT6

4.52e-0415302M22009
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SYT1 SLC6A13

7.32e-0419302M927
PathwayREACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION

SYT1 SLC6A13

7.32e-0419302MM15523
Pubmed

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.03e-3311401116863688
Pubmed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3B TBC1D3F

2.60e-127440716625196
Pubmed

Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.

TBC1D3 TBC1D3D TBC1D3F

5.63e-0944038406013
Pubmed

PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

TBC1D3 TBC1D3D TBC1D3F

5.63e-09440312359748
Pubmed

The Tre2 (USP6) oncogene is a hominoid-specific gene.

TBC1D3 TBC1D3D TBC1D3C

1.41e-08540312604796
Pubmed

Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.

TBC1D3 TBC1D3D TBC1D3F

1.41e-0854038471161
Pubmed

Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.

FUT5 FUT6

1.29e-06240217604274
Pubmed

Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.

FUT5 FUT6

1.29e-0624021339443
Pubmed

Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

FUT5 FUT6

3.87e-0634027650030
Pubmed

Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.

FUT5 FUT6

3.87e-06340230808544
Pubmed

Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21.

FUT5 FUT6

3.87e-0634027782074
Pubmed

Diversity of human copy number variation and multicopy genes.

TBC1D3E TBC1D3G

3.87e-06340221030649
Pubmed

miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.

FUT5 FUT6

7.73e-06440228771224
Pubmed

Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.

FUT5 FUT6

7.73e-06440219349624
Pubmed

Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

FUT5 FUT6

1.29e-05540229593094
Pubmed

Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.

FUT5 FUT6

1.34e-041540211698403
Pubmed

Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.

WNT5B ATP4A

4.45e-042740232878924
Pubmed

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.

TBC1D3 TBC1D3F

6.26e-043240223535730
Pubmed

RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development.

BMPR2 INHA

7.49e-043540232281291
Pubmed

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.

CHD3 PRPF8

1.03e-034140222720776
Pubmed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.

SI ATP4A

1.03e-034140223676500
Pubmed

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.

BMPR2 ABL1 INHA

1.11e-0317740322560297
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

TBC1D3 TBC1D3F

1.13e-034340219077034
CytobandEnsembl 112 genes in cytogenetic band chr17q12

TBC1D3E TBC1D3 TBC1D3L TBC1D3H TBC1D3I TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

6.16e-191494011chr17q12
Cytoband17q12

TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F

2.61e-089940517q12
Cytoband12p13.3

WNT5B SLC6A13

3.17e-043040212p13.3
Cytoband19p13.3

NDUFS7 FUT5 FUT6

1.17e-0323740319p13.3
GeneFamilyFucosyltransferases|Blood group antigens

FUT5 FUT6

8.10e-0513192434
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

4.32e-1490389PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.10e-10213389PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.10e-10213389PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasDE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.42e-10242389PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.28e-09281389PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.28e-09281389PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

3.98e-09320389PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlasEctoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

WNT5B SYT1 TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

1.81e-0610753811PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

BMPR2 TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

2.51e-0511533810PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlasEctoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

WNT5B TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F BIK

3.46e-0514663811PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 5-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3L TBC1D3H TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F

7.54e-051049389PCBC_ratio_MESO-15_vs_MESO-5_cfr-2X-p05
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_1000_k-means-cluster#3

WNT5B FUT5 TBC1D3C TBC1D3B TBC1D3F RD3

1.74e-04471386ratio_ECTO_vs_SC_1000_K3
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_1000

WNT5B TBC1D3 TBC1D3H FUT5 TBC1D3C TBC1D3B TBC1D3F RD3

2.96e-04986388PCBC_ratio_ECTO_vs_SC_1000
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC|lymph-node_spleen / Manually curated celltypes from each tissue

WNT5B PIEZO2 TENM2 ATP4A

1.53e-051723941b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCellMild/Remission-B_intermediate-10|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SYT1 BMPR2 CHD3 RHOBTB2

1.95e-05183394278064c9f0582463b83bf156d34e77f60187613b
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TBC1D3L TBC1D3D ATP4A RHCE

1.99e-05184394cd2919dc8e90d03f57eb43f59f7da9bcd676496e
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GHSR SYT1 KLHL33 TENM2

2.65e-051983948f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GHSR SYT1 KLHL33 TENM2

2.65e-05198394e3e0aa3ef20b2370f5b133048510677aaa562dfa
Diseasealpha-(1;3)-fucosyltransferase 5 measurement

FUT5 FUT6

5.99e-064302EFO_0021979
Diseasegalactoside 3(4)-L-fucosyltransferase measurement

FUT5 FUT6

2.09e-057302EFO_0021853
Diseasealpha-(1,3)-fucosyltransferase 5 measurement

FUT5 FUT6

2.09e-057302EFO_0020136
DiseaseCCL4 measurement

TBC1D3 TBC1D3F

1.88e-0420302EFO_0004751
Diseaseserum carcinoembryonic antigen measurement

FUT5 FUT6

1.88e-0420302EFO_0005760
Diseasemacrophage inflammatory protein 1b measurement

TBC1D3 TBC1D3B TBC1D3F

3.55e-04136303EFO_0008219
Diseasecandidiasis (implicated_via_orthology)

FUT5 FUT6

9.21e-0444302DOID:1508 (implicated_via_orthology)
DiseaseIntellectual Disability

SYT1 CHD3 LAS1L RHOBTB2

1.04e-03447304C3714756
Diseasepyroglutamine measurement

SLC6A13 ABL1

1.59e-0358302EFO_0005408

Protein segments in the cluster

PeptideGeneStartEntry
SNDMRLNSWFDPSWR

BRINP3

516

Q76B58
LNSWFDPSWRKRMLL

BRINP3

521

Q76B58
RPNEIPNWTAFSRWK

CRYBG3

2811

Q68DQ2
WLPTWRPTSMSQLKN

ABHD4

16

Q8TB40
ENIMRFWRSPNPGSW

BIK

116

Q13323
PDMALRQPSRAVWWA

KLHL33

221

A6NCF5
WRLFNCSASLDWPRM

LAS1L

451

Q9Y4W2
MPLDLVRLWQYRPWN

GHSR

96

Q92847
RWGMPPQDAFTTQWL

CHD3

1426

Q12873
MTSSLQRPWRVPWLP

BMPR2

1

Q13873
LMRACWQWNPSDRPS

ABL1

471

P00519
RQGQRWIWFSMESPS

FUT6

126

P51993
RRSTPLMSWPWSPSA

INHA

231

P05111
LMSWPWSPSALRLLQ

INHA

236

P05111
LMPQWSRALQPWWSS

PKD1L1

2121

Q8TDX9
NFMPIRFQWWLVPLP

ATP4A

991

P20648
PPTRPQGQRWIWFSM

FUT5

136

Q11128
WSDMLANPRRPIAQW

SYT1

391

P21579
QPKRRWLFWNSPSSP

RHOBTB2

696

Q9BYZ6
PFMSQERTVWLPWNS

TENM2

986

Q9NT68
LNWNTWGMFTRDQPP

SI

1126

P14410
MSLISWLRWNEAPSR

RD3

1

Q7Z3Z2
SWRFLQWNSMPRLPT

TBC1D3L

446

B9A6J9
VNWARRSSLWPMTFG

NDUFS7

71

O75251
LNQIPNRRFTLWWSP

PRPF8

1526

Q6P2Q9
SWRFLQWNSMPRLPT

TBC1D3B

446

A6NDS4
SWRFLQWNSMPRLPT

TBC1D3H

446

P0C7X1
AMRGIVRTWWSQPPR

URGCP

231

Q8TCY9
LWMFWPSVNSPLLRS

RHCE

216

P18577
ALRMNWRVWTPLQFI

PXMP2

151

Q9NR77
SWRFLQWNSMPRLPT

TBC1D3F

446

A6NER0
LYPNLTRLWDPQVWM

SLC6A13

266

Q9NSD5
LWAMLSVPRPSRRFW

PIEZO2

1951

Q9H5I5
WWSLALNPVQRPEMF

WNT5B

26

Q9H1J7
SWRFLQWNSMPRLPT

TBC1D3E

446

A0A087X179
SWRFLQWNSMPRLPT

TBC1D3D

446

A0A087WVF3
MSLFPNPSWWLLNTS

VN1R3

256

Q9BXE9
SWRFLQWNSMPRLPT

TBC1D3G

446

Q6DHY5
SWRFLQWNSMPRLPT

TBC1D3

446

Q8IZP1
SWRFLQWNSMPRLPT

TBC1D3K

446

A0A087X1G2
SWRFLQWNSMPRLPT

TBC1D3I

446

A0A087WXS9
SWRFLQWNSMPRLPT

TBC1D3C

446

Q6IPX1