Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRAF2 STUB1 TRIM54 MDM2 TRIP12 RFPL4B ZNF451 ARIH2 TRIM63 PRKN TNFAIP3 PJA1 RNF122 UBE2Z	5.85e-06	512	129	14	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRAF2 STUB1 TRIM54 MDM2 TRIP12 RFPL4B ZNF451 ARIH2 TRIM63 PRKN TNFAIP3 PJA1 RNF122 UBE2Z	9.03e-06	532	129	14	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRAF2 STUB1 TRIM54 MDM2 TRIP12 RFPL4B ARIH2 TRIM63 PRKN TNFAIP3 PJA1 RNF122 UBE2Z	1.22e-05	473	129	13	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	STUB1 TRIM54 MDM2 TRIP12 RFPL4B ZNF451 ARIH2 TRIM63 PRKN PJA1 RNF122	5.58e-05	398	129	11	GO:0061659
GeneOntologyMolecularFunction	acyltransferase activity	TRAF2 STUB1 TRIM54 MDM2 ELP3 TRIP12 RFPL4B ZNF451 ARIH2 TRIM63 PRKN TNFAIP3 PJA1 RNF122 UBE2Z	1.46e-04	775	129	15	GO:0016746
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	STUB1 TRIM54 MDM2 TRIP12 RFPL4B ARIH2 TRIM63 PRKN PJA1 RNF122	1.54e-04	372	129	10	GO:0061630
GeneOntologyMolecularFunction	zinc ion binding	KDM5B TRAF2 POLR2L TRIM54 MDM2 TRIP12 ZFPM2 AARS2 ARIH2 TRIM63 PRKN NR1H2 CDA TNFAIP3 RNF24	6.41e-04	891	129	15	GO:0008270
GeneOntologyBiologicalProcess	complement activation, alternative pathway	CFHR5 CR1 CR2 C7	5.26e-06	19	129	4	GO:0006957
HumanPheno	Astrocytoma	APC2 APC MDM2 KRIT1 MSH6	5.50e-06	25	55	5	HP:0009592
HumanPheno	Glioma	APC2 APC MDM2 KRIT1 MSH6 SMO	1.04e-05	48	55	6	HP:0009733
HumanPheno	Neuroepithelial neoplasm	APC2 APC MDM2 KRIT1 MSH6 SMO ALK	4.99e-05	92	55	7	HP:0030063
HumanPheno	Neuroectodermal neoplasm	APC2 APC MDM2 KRIT1 MSH6 SMO ALK	5.74e-05	94	55	7	HP:0030061
HumanPheno	Nervous tissue neoplasm	APC2 APC MDM2 KRIT1 MSH6 SMO ALK	5.74e-05	94	55	7	HP:0030060
HumanPheno	Malignant neoplasm of the central nervous system	APC2 APC MDM2 KRIT1 MSH6 SMO ALK	8.00e-05	99	55	7	HP:0100836
HumanPheno	Abnormal astrocyte morphology	APC2 APC MDM2 KRIT1 MSH6	1.19e-04	46	55	5	HP:0100707
HumanPheno	Abnormal glial cell morphology	APC2 APC MDM2 KRIT1 MSH6 ZNF335 PRKN SMO MOCS1	1.47e-04	187	55	9	HP:0100705
MousePheno	small thymus	STK36 TRAF2 STUB1 CTC1 MDM2 ZAP70 JAK1 FZD9 DIP2C PWWP3A NCKAP1L	9.83e-06	286	105	11	MP:0000706
Domain	-	KDM5B TRAF2 STUB1 PHF23 TRIM54 MDM2 RFPL4B PHF3 ARIH2 TRIM63 PJA1 BSN RNF122 RNF24	3.03e-06	449	130	14	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KDM5B TRAF2 STUB1 PHF23 TRIM54 MDM2 RFPL4B PHF3 ARIH2 TRIM63 PJA1 BSN RNF122 RNF24	3.91e-06	459	130	14	IPR013083
Domain	ZF_RING_1	TRAF2 TRIM54 MDM2 RFPL4B ARIH2 TRIM63 PRKN PJA1 RNF122 RNF24	3.71e-05	291	130	10	PS00518
Domain	ZF_RING_2	TRAF2 TRIM54 MDM2 RFPL4B ARIH2 TRIM63 PRKN PJA1 RNF122 RNF24	4.54e-05	298	130	10	PS50089
Domain	APC_r	APC2 APC	4.81e-05	2	130	2	PF05923
Domain	SAMP	APC2 APC	4.81e-05	2	130	2	PF05924
Domain	APC_dom	APC2 APC	4.81e-05	2	130	2	IPR026831
Domain	APC_N	APC2 APC	4.81e-05	2	130	2	IPR032038
Domain	APC_basic_dom	APC2 APC	4.81e-05	2	130	2	IPR009234
Domain	Apc_fam	APC2 APC	4.81e-05	2	130	2	IPR026818
Domain	APC_rpt	APC2 APC	4.81e-05	2	130	2	IPR009223
Domain	SAMP	APC2 APC	4.81e-05	2	130	2	IPR009224
Domain	APC_basic	APC2 APC	4.81e-05	2	130	2	PF05956
Domain	APC_N_CC	APC2 APC	4.81e-05	2	130	2	PF16689
Domain	RING	TRAF2 TRIM54 MDM2 RFPL4B ARIH2 TRIM63 PJA1 RNF122 RNF24	2.87e-04	305	130	9	SM00184
Domain	Znf_RING	TRAF2 TRIM54 MDM2 RFPL4B ARIH2 TRIM63 PJA1 RNF122 RNF24	4.67e-04	326	130	9	IPR001841
Domain	Sushi	CFHR5 CR1 CR2 C7	4.68e-04	52	130	4	PF00084
Domain	CCP	CFHR5 CR1 CR2 C7	5.41e-04	54	130	4	SM00032
Domain	PROTEIN_KINASE_TYR	FLT4 ZAP70 JAK1 TESK2 ALK	5.84e-04	97	130	5	PS00109
Domain	Tyr_kinase_AS	FLT4 ZAP70 JAK1 TESK2 ALK	5.84e-04	97	130	5	IPR008266
Domain	SUSHI	CFHR5 CR1 CR2 C7	6.22e-04	56	130	4	PS50923
Domain	Sushi_SCR_CCP_dom	CFHR5 CR1 CR2 C7	6.65e-04	57	130	4	IPR000436
Domain	cEGF	FBLN2 SCUBE3 LTBP3	7.62e-04	26	130	3	PF12662
Domain	cEGF	FBLN2 SCUBE3 LTBP3	7.62e-04	26	130	3	IPR026823
Domain	Elp3	ELP3 MOCS1	9.87e-04	7	130	2	SM00729
Domain	Elp3/MiaB/NifB	ELP3 MOCS1	9.87e-04	7	130	2	IPR006638
Domain	Znf_C3HC4_RING-type	TRAF2 TRIM54 TRIM63 PJA1 RNF122 RNF24	1.30e-03	172	130	6	IPR018957
Domain	Coatomer/calthrin_app_sub_C	AP4E1 AP4B1	1.31e-03	8	130	2	IPR009028
Domain	rSAM	ELP3 MOCS1	1.68e-03	9	130	2	IPR007197
Domain	Radical_SAM	ELP3 MOCS1	1.68e-03	9	130	2	PF04055
Domain	VWFC_1	DGCR2 VWF CHRD	1.99e-03	36	130	3	PS01208
Domain	E3_UB_ligase_RBR	ARIH2 PRKN	2.09e-03	10	130	2	IPR031127
Domain	Pkinase_Tyr	FLT4 ZAP70 JAK1 TESK2 ALK	2.09e-03	129	130	5	PF07714
Domain	BTB	HIC2 KBTBD2 KLHL29 KLHL15 ZBTB18	2.24e-03	131	130	5	PF00651
Domain	VWFC_2	DGCR2 VWF CHRD	2.33e-03	38	130	3	PS50184
Domain	VWC	DGCR2 VWF CHRD	2.33e-03	38	130	3	SM00214
Domain	Frizzled	FZD9 SMO	2.54e-03	11	130	2	IPR000539
Domain	Frizzled	FZD9 SMO	2.54e-03	11	130	2	PF01534
Domain	Frizzled	FZD9 SMO	2.54e-03	11	130	2	SM01330
Domain	Ser-Thr/Tyr_kinase_cat_dom	FLT4 ZAP70 JAK1 TESK2 ALK	2.80e-03	138	130	5	IPR001245
Domain	COS	TRIM54 TRIM63	3.03e-03	12	130	2	PS51262
Domain	COS_domain	TRIM54 TRIM63	3.03e-03	12	130	2	IPR017903
Domain	VWF_dom	DGCR2 VWF CHRD	3.10e-03	42	130	3	IPR001007
Domain	BTB-kelch_protein	KBTBD2 KLHL29 KLHL15	3.32e-03	43	130	3	IPR017096
Domain	Tyr_kinase_cat_dom	FLT4 ZAP70 JAK1 ALK	3.33e-03	88	130	4	IPR020635
Domain	TyrKc	FLT4 ZAP70 JAK1 ALK	3.33e-03	88	130	4	SM00219
Domain	-	DGCR2 C7 ALK	4.02e-03	46	130	3	4.10.400.10
Domain	IBR	ARIH2 PRKN	4.14e-03	14	130	2	PF01485
Domain	IBR	ARIH2 PRKN	4.14e-03	14	130	2	SM00647
Domain	TUDOR	TDRD15 TDRD7	4.14e-03	14	130	2	PF00567
Domain	uDENN	DENND5B DENND4B	4.14e-03	14	130	2	SM00800
Domain	LDLRA_1	DGCR2 C7 ALK	4.53e-03	48	130	3	PS01209
Domain	-	STK36 APC2 APC TRIP12 AP4E1 AP4B1	4.63e-03	222	130	6	1.25.10.10
Domain	zf-C3HC4	TRAF2 TRIM54 TRIM63 PJA1 RNF122 RNF24	4.73e-03	223	130	6	PF00097
Domain	Clathrin/coatomer_adapt-like_N	AP4E1 AP4B1	4.76e-03	15	130	2	IPR002553
Domain	uDENN	DENND5B DENND4B	4.76e-03	15	130	2	PF03456
Domain	Adaptin_N	AP4E1 AP4B1	4.76e-03	15	130	2	PF01602
Domain	IBR_dom	ARIH2 PRKN	4.76e-03	15	130	2	IPR002867
Domain	LDrepeatLR_classA_rpt	DGCR2 C7 ALK	4.81e-03	49	130	3	IPR002172
Domain	LDLa	DGCR2 C7 ALK	4.81e-03	49	130	3	SM00192
Domain	LDLRA_2	DGCR2 C7 ALK	4.81e-03	49	130	3	PS50068
Domain	BTB	HIC2 KBTBD2 KLHL29 KLHL15 ZBTB18	5.26e-03	160	130	5	PS50097
Domain	DENN	DENND5B DENND4B	5.41e-03	16	130	2	SM00799
Domain	MAM_1	PTPRM ALK	5.41e-03	16	130	2	PS00740
Domain	DENN	DENND5B DENND4B	5.41e-03	16	130	2	PF02141
Domain	dDENN	DENND5B DENND4B	5.41e-03	16	130	2	PF03455
Domain	UDENN	DENND5B DENND4B	5.41e-03	16	130	2	PS50946
Domain	DDENN	DENND5B DENND4B	5.41e-03	16	130	2	PS50947
Domain	WAP	PI3 SLPI	5.41e-03	16	130	2	SM00217
Domain	dDENN	DENND5B DENND4B	5.41e-03	16	130	2	SM00801
Domain	dDENN_dom	DENND5B DENND4B	5.41e-03	16	130	2	IPR005112
Domain	uDENN_dom	DENND5B DENND4B	5.41e-03	16	130	2	IPR005113
Domain	DENN	DENND5B DENND4B	5.41e-03	16	130	2	PS50211
Domain	DENN_dom	DENND5B DENND4B	5.41e-03	16	130	2	IPR001194
Domain	WAP	PI3 SLPI	5.41e-03	16	130	2	PF00095
Domain	Frizzled/SFRP	FZD9 SMO	5.41e-03	16	130	2	IPR015526
Domain	zf-RING_2	PJA1 RNF122 RNF24	5.68e-03	52	130	3	PF13639
Domain	Znf_RING_CS	TRAF2 TRIM54 RFPL4B ARIH2 TRIM63	5.68e-03	163	130	5	IPR017907
Domain	-	PI3 SLPI	6.11e-03	17	130	2	4.10.75.10
Domain	WAP	PI3 SLPI	6.11e-03	17	130	2	PS51390
Domain	MAM	PTPRM ALK	6.84e-03	18	130	2	PF00629
Domain	MAM_dom	PTPRM ALK	6.84e-03	18	130	2	IPR000998
Domain	MAM_2	PTPRM ALK	6.84e-03	18	130	2	PS50060
Pathway	KEGG_BASAL_CELL_CARCINOMA	STK36 APC2 APC FZD9 SMO	3.33e-05	55	95	5	M17807
Pathway	KEGG_PATHWAYS_IN_CANCER	STK36 LAMB4 TRAF2 APC2 APC MDM2 JAK1 FZD9 MSH6 SMO	6.59e-05	325	95	10	M12868
Pubmed	S5a/Rpn10, a UIM-protein, as a universal substrate for ubiquitination.	STUB1 MDM2 TRIM63 PRKN	2.46e-08	9	132	4	22350919
Pubmed	The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition.	STUB1 MDM2 TRIM63 PRKN	1.38e-07	13	132	4	19240029
Pubmed	Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases.	STUB1 TRIM54 MDM2 TRIM63	3.48e-07	16	132	4	23695783
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KDM5B TRAF2 VWF STUB1 FEZF2 APC2 APC TRIP12 CBR3 PAICS KRIT1 JAK1 ZNF18 ZNF451 ARIH2 NR1H2 LTBP3 PJA1 PADI2	4.19e-07	1285	132	19	35914814
Pubmed	E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system.	STUB1 TRIM54 TRIM63	1.06e-06	6	132	3	34702928
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	CFHR5 CR1 CR2 C7	5.76e-06	31	132	4	19344414
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	TRIM54 MDM2 TRIM63 PJA1 RNF122 UBE2Z	6.20e-06	118	132	6	19690564
Pubmed	Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.	STUB1 MDM2 PRKN	8.62e-06	11	132	3	16714300
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	VWF CTC1 TRIM54 MDM2 CR1 KLHL29 AARS2 PDE8B ZNF335 IL17RD RNF122	8.95e-06	552	132	11	10737800
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	FLT4 FBXL12 KLHL29 JAK1 TESK2 KLHL15 PRKN TNFAIP3 ALK	1.33e-05	372	132	9	22939624
Pubmed	Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli.	PI3 SLPI	1.43e-05	2	132	2	15034071
Pubmed	KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.	KIF4A KIF4B	1.43e-05	2	132	2	36482480
Pubmed	Complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) cooperate in the binding of hydrolyzed complement factor 3 (C3i) to human B lymphocytes.	CR1 CR2	1.43e-05	2	132	2	14635039
Pubmed	BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy.	PRKN BSN	1.43e-05	2	132	2	32718208
Pubmed	The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.	KIF4A KIF4B	1.43e-05	2	132	2	30081192
Pubmed	PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.	APC PRKN	1.43e-05	2	132	2	20696900
Pubmed	Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.	KIF4A KIF4B	1.43e-05	2	132	2	31067151
Pubmed	Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin.	PI3 SLPI	1.43e-05	2	132	2	12819058
Pubmed	The ubiquitin E3 ligase Parkin regulates neuronal CaV1.3 channel functional expression.	CACNA1D PRKN	1.43e-05	2	132	2	36350063
Pubmed	Cellular motor protein KIF-4 associates with retroviral Gag.	KIF4A KIF4B	1.43e-05	2	132	2	10559369
Pubmed	Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.	PI3 SLPI	1.43e-05	2	132	2	2039600
Pubmed	Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.	PI3 SLPI	1.43e-05	2	132	2	17200145
Pubmed	The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells.	CR1 CR2	1.43e-05	2	132	2	11981823
Pubmed	KIF4 regulates midzone length during cytokinesis.	KIF4A KIF4B	1.43e-05	2	132	2	21565503
Pubmed	A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.	KIF4A KIF4B	1.43e-05	2	132	2	7929562
Pubmed	Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion.	TRAF2 STUB1	1.43e-05	2	132	2	21793045
Pubmed	Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.	CR1 CR2	1.43e-05	2	132	2	1708808
Pubmed	Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.	PDCD2 PRKN	1.43e-05	2	132	2	19146857
Pubmed	Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility.	CR2 ZBTB18	1.43e-05	2	132	2	25817480
Pubmed	The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease.	PI3 SLPI	1.43e-05	2	132	2	11667971
Pubmed	Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration.	LPP PALLD	1.43e-05	2	132	2	17322171
Pubmed	Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.	APC2 APC	1.43e-05	2	132	2	27694902
Pubmed	Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice.	PRKN BSN	1.43e-05	2	132	2	32364493
Pubmed	Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.	KIF4A KIF4B	1.43e-05	2	132	2	31486502
Pubmed	Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.	KIF4A KIF4B	1.43e-05	2	132	2	10773663
Pubmed	Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.	CACNA1D BSN	1.43e-05	2	132	2	23467361
Pubmed	Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.	KIF4A KIF4B	1.43e-05	2	132	2	31616463
Pubmed	TRIAD1 is negatively regulated by the MDM2 E3 ligase.	MDM2 ARIH2	1.43e-05	2	132	2	22940738
Pubmed	Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.	KIF4A KIF4B	1.43e-05	2	132	2	28350061
Pubmed	Lack of association of TNFAIP3 and JAK1 with Behçet's disease in the European population.	JAK1 TNFAIP3	1.43e-05	2	132	2	26005883
Pubmed	Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.	CACNA1D BSN	1.43e-05	2	132	2	24442635
Pubmed	Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.	APC MDM2	1.43e-05	2	132	2	27617574
Pubmed	Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8.	PI3 SLPI	1.43e-05	2	132	2	11868825
Pubmed	Comparative functional evolution of human and mouse CR1 and CR2.	CR1 CR2	1.43e-05	2	132	2	18713965
Pubmed	Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection.	PI3 SLPI	1.43e-05	2	132	2	19095674
Pubmed	Cervical Expression of Elafin and SLPI in Pregnancy and Their Association With Preterm Labor.	PI3 SLPI	1.43e-05	2	132	2	25559229
Pubmed	Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury.	LPP PALLD	1.43e-05	2	132	2	19205907
Pubmed	Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.	KIF4A KIF4B	1.43e-05	2	132	2	24658398
Pubmed	Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity.	CR1 CR2	1.43e-05	2	132	2	37833411
Pubmed	New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.	TRIM54 TRIM63	1.43e-05	2	132	2	25801283
Pubmed	Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family.	PI3 SLPI	1.43e-05	2	132	2	17964057
Pubmed	[THE COMBINATION OF EXPRESSION OF MARKERS CR1 AND CR2 (CD35/CD21) IN DIAGNOSTIC OF B-CELL LYMPHOPROLIFERATIVE DISEASES].	CR1 CR2	1.43e-05	2	132	2	26189291
Pubmed	APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.	APC2 APC	1.43e-05	2	132	2	31291912
Pubmed	Structural basis for the ATP-induced isomerization of kinesin.	KIF4A KIF4B	1.43e-05	2	132	2	23500491
Pubmed	Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization.	CR1 CR2	1.43e-05	2	132	2	23440418
Pubmed	Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.	KIF4A KIF4B	1.43e-05	2	132	2	9658142
Pubmed	The DNA sequence and analysis of human chromosome 6.	PDCD2 SLC35B3 GRM1 AARS2 PHF3 ZNF451 SCUBE3 PRKN TNFAIP3 DNAH8 MOCS1	2.69e-05	622	132	11	14574404
Pubmed	Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins.	APC MSH6	4.28e-05	3	132	2	19029948
Pubmed	Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.	AP4E1 AP4B1	4.28e-05	3	132	2	26542808
Pubmed	Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.	TRIM54 TRIM63	4.28e-05	3	132	2	18222470
Pubmed	Tumor formation via loss of a molecular motor protein.	KIF4A KIF4B	4.28e-05	3	132	2	16890532
Pubmed	KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.	KIF4A KIF4B	4.28e-05	3	132	2	19158085
Pubmed	Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.	KIF4A KIF4B	4.28e-05	3	132	2	10978527
Pubmed	The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.	TRAF2 TNFAIP3	4.28e-05	3	132	2	8692885
Pubmed	Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.	MDM2 SMO	4.28e-05	3	132	2	18359851
Pubmed	The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.	APC MSH6	4.28e-05	3	132	2	11691815
Pubmed	Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein.	STUB1 ALK	4.28e-05	3	132	2	15126367
Pubmed	Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.	CR1 CR2	4.28e-05	3	132	2	7690834
Pubmed	Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma.	TRAF2 PRKN	4.28e-05	3	132	2	31558697
Pubmed	A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.	CR1 CR2	4.28e-05	3	132	2	3782802
Pubmed	TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.	MDM2 ARIH2	4.28e-05	3	132	2	22819825
Pubmed	Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry.	CR1 CR2	4.28e-05	3	132	2	2528587
Pubmed	Mdm2 enhances ligase activity of parkin and facilitates mitophagy.	MDM2 PRKN	4.28e-05	3	132	2	32193420
Pubmed	Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein.	CR1 CR2	4.28e-05	3	132	2	7528766
Pubmed	KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.	KIF4A KIF4B	4.28e-05	3	132	2	16630823
Pubmed	Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.	TRAF2 PRKN	4.28e-05	3	132	2	23608757
Pubmed	Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.	TRAF2 PRKN	4.28e-05	3	132	2	17314283
Pubmed	Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain.	GDF10 CHRD	4.28e-05	3	132	2	10767089
Pubmed	DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3.	SCUBE3 DEPDC1B	4.28e-05	3	132	2	35088579
Pubmed	The murine complement receptor gene family. IV. Alternative splicing of Cr2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR2 and CR1.	CR1 CR2	4.28e-05	3	132	2	2139460
Pubmed	A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.	TRAF2 TNFAIP3	4.28e-05	3	132	2	22525270
Pubmed	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	KIF4A KIF4B	4.28e-05	3	132	2	35579738
Pubmed	Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.	APC2 APC	4.28e-05	3	132	2	23840886
Pubmed	CHIP chaperones wild type p53 tumor suppressor protein.	STUB1 MDM2	4.28e-05	3	132	2	17666403
Pubmed	A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.	APC TNFAIP3	4.28e-05	3	132	2	23671587
Pubmed	Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells.	APC SLC27A4	4.28e-05	3	132	2	22871340
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	FLT4 CR1 CR2 CD200R1 ALK	4.32e-05	101	132	5	23382219
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	TRAF2 VWF STUB1 APC2 PAICS ZFPM2 TDRD7 FBLN2 CHRD LTBP3	5.83e-05	560	132	10	21653829
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	STUB1 MDM2 PRKN	6.76e-05	21	132	3	37005481
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CTC1 POLD2 APC CDCP1 TRIP12 PAICS TEX264 INTS13 LPP TNFAIP3 PJA1 IL17RD RNF122 NCKAP1L	6.78e-05	1084	132	14	11544199
Pubmed	Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.	APC SMO	8.54e-05	4	132	2	19861162
Pubmed	Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.	STUB1 PRKN	8.54e-05	4	132	2	17512523
Pubmed	Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps.	APC PRKN	8.54e-05	4	132	2	34126796
Pubmed	Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.	MDM2 JAK1	8.54e-05	4	132	2	24413661
Pubmed	Chaperone-dependent stabilization and degradation of p53 mutants.	STUB1 MDM2	8.54e-05	4	132	2	18223694
Pubmed	FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma.	FEZF2 MDM2	8.54e-05	4	132	2	23677067
Pubmed	Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.	APC KRIT1	8.54e-05	4	132	2	20007487
Pubmed	Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.	CR1 CR2	8.54e-05	4	132	2	16127466
Pubmed	Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.	KIF4A KIF4B	8.54e-05	4	132	2	18684836
Pubmed	Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis.	STUB1 MDM2	8.54e-05	4	132	2	25543083
Interaction	UBE2D3 interactions	TRAF2 STUB1 FBXL12 TRIM54 MDM2 ARIH2 TRIM63 PRKN TNFAIP3 PJA1 RNF122	2.12e-06	283	129	11	int:UBE2D3
Interaction	UBE2D1 interactions	TRAF2 STUB1 TRIM54 MDM2 TRIP12 ARIH2 TRIM63 PRKN NR1H2 TNFAIP3 RNF122	3.06e-06	294	129	11	int:UBE2D1
Interaction	UBE2N interactions	TRAF2 FLT4 STUB1 TRIM54 MDM2 ARIH2 TRIM63 PRKN TNFAIP3 RNF122 ALK	1.63e-05	351	129	11	int:UBE2N
Interaction	UBE2E3 interactions	STUB1 TRIM54 MDM2 ARIH2 TRIM63 PRKN PJA1	2.27e-05	132	129	7	int:UBE2E3
Interaction	JOSD1 interactions	STUB1 TRIM54 FBLN2 TRIM63 PJA1	2.92e-05	56	129	5	int:JOSD1
Interaction	UBE2D2 interactions	TRAF2 STUB1 TRIM54 MDM2 TRIP12 ARIH2 TRIM63 PRKN PJA1 RNF122	3.90e-05	318	129	10	int:UBE2D2
Interaction	ATXN3L interactions	TRIM54 TRIM63 PJA1	4.07e-05	11	129	3	int:ATXN3L
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	SFMBT1 CACNA1D CDCP1 TEX264 ARIH2 BSN	3.21e-04	316	132	6	chr3p21
Cytoband	Xq13.1	KIF4A GJB1 PJA1	3.66e-04	48	132	3	Xq13.1
GeneFamily	Complement system\|Sushi domain containing	CFHR5 CR1 CR2 C7	4.35e-05	36	99	4	492
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR5 CR1 CR2 C7	2.67e-04	57	99	4	1179
GeneFamily	Ring finger proteins	TRAF2 TRIM54 RFPL4B TRIM63 PJA1 RNF122 RNF24	7.89e-04	275	99	7	58
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	HIC2 KBTBD2 KLHL29 KLHL15 ZBTB18	8.50e-04	134	99	5	861
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD9 SMO	1.58e-03	11	99	2	286
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 HIC2 TDRD7 AARS2 INTS13 TNFAIP3 PADI2	9.71e-07	176	132	7	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VWF THSD7A MYH13 CCDC178 FBLN2 C7 RNF122	1.99e-06	196	132	7	5609b2d93172a488b35d854298a3a4e504e17e28
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Mup5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE2 FEZF2 THSD7B ZFPM2 NFIA TNFAIP3	2.20e-06	127	132	6	6df92f80b8922ca00eb383f79cd8dda4d602adfc
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE2 DLG5 FEZF2 THSD7B ZFPM2 NFIA	2.63e-06	131	132	6	81efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCell	LPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SFMBT1 CHD8 HPS3 ZNF18 PI3 PHF3	4.20e-06	142	132	6	b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCell	Adult-Mesenchymal-chondrocyte-D122\|Adult / Lineage, Cell type, age group and donor	SFMBT1 CACNA1D TRAF2 MYH13 C7 MOCS1	5.33e-06	148	132	6	81a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CCDC178 GRM1 GDF10 ZFPM2 PTPRM CDA	5.98e-06	151	132	6	090b067873740c282865e2d02cf47d5cb3dd7607
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GDF10 ZNF18 FBLN2 CHRD PRKN C7	6.45e-06	153	132	6	d5f5399ebbbff508c96ce7f01272716b61597ab5
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GDF10 ZNF18 FBLN2 CHRD PRKN C7	6.45e-06	153	132	6	32cf4ca828d228f23366480305592f9813fed7ff
ToppCell	facs-Heart-LV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAP70 CD200R1 TNFAIP3 BSN PADI2 DNAH8	1.18e-05	170	132	6	71e5e27c3c4e6cc8dc9b063bd51c21c049f54416
ToppCell	facs-Heart-LV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAP70 CD200R1 TNFAIP3 BSN PADI2 DNAH8	1.18e-05	170	132	6	255bbbd00d0e17510c5a8c5faa43ed90d887a9de
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 CTC1 HPS3 PTPRM ZNF451 IL17RD	1.26e-05	172	132	6	1f335ccb92b22d0412954e8fc3af212f96410b67
ToppCell	droplet-Liver-nan-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 CTC1 HPS3 PTPRM ZNF451 IL17RD	1.26e-05	172	132	6	bb96c896d125e10b71e94e2bdad243899045af5c
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NWD1 THSD7A FZD9 FBLN2 PTPRM CDA	1.48e-05	177	132	6	d68132e145bd413404fdbe215b5dbe520e756e50
ToppCell	NS-control-d_0-4-Epithelial-Secretory-diff\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PI3 SLPI TRIM63 MOCS1	1.59e-05	51	132	4	a6f623dba72ce85683e692a68095926e4e71b765
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK14 FETUB SLPI TNFAIP3 RNF122 RNF24	1.63e-05	180	132	6	18bf8561ad3aa9787d2a8ef942a96f641734c608
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CPAMD8 THSD7A CCDC178 FBLN2 PTPRM CDA	1.68e-05	181	132	6	0ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 NWD1 VWF THSD7A FBLN2 PTPRM	1.90e-05	185	132	6	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	droplet-Marrow-nan-18m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 VWF ZAP70 SMO LTBP3 BSN	1.90e-05	185	132	6	de353368f4f6a7a0a66e391d586879876fbe2734
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF THSD7A PI3 FBLN2 ALDH1A3 PALLD	1.96e-05	186	132	6	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	Control-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	VWF CCDC178 CDA C7 RNF122 DEPDC1B	2.02e-05	187	132	6	5429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KDM5B THSD7A NFIA LRRTM2 PWWP3A ZBTB18	2.08e-05	188	132	6	e239bcdbd210a398a5850cb6fbf171d402f45a4f
ToppCell	COVID-19_Severe-Myeloid_G-Neutrophil\|COVID-19_Severe / Disease group, lineage and cell class	CR1 PI3 SLPI CDA RNF24 PADI2	2.14e-05	189	132	6	a62f4c445ede00d15b74bee65f4e4fb54cfd4d32
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CR1 PI3 SLPI CDA RNF24 PADI2	2.14e-05	189	132	6	f6b2b4824505f0119a017fdb73c55418fb651645
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CR1 PI3 SLPI CDA RNF24 PADI2	2.14e-05	189	132	6	db8e314ce95c32542bb4015a77032a33211fea0b
ToppCell	facs-GAT-Fat-24m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD7A GDF10 FBLN2 NFIA C7 ALDH1A3	2.21e-05	190	132	6	3720e64129f3f3268b1dc14031a76f41c38241c2
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD7A GDF10 FBLN2 NFIA C7 ALDH1A3	2.21e-05	190	132	6	73a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD7A GDF10 FBLN2 NFIA C7 ALDH1A3	2.21e-05	190	132	6	b55cf1fb586b724295b7b038483249847bb344fc
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF THSD7A ZFPM2 KLHL29 FBLN2 LTBP3	2.21e-05	190	132	6	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CR1 PI3 SLPI CDA RNF24 PADI2	2.27e-05	191	132	6	b9b091d6b352d5128bb864ff52d2e5fb3387b766
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	CPAMD8 VWF THSD7A FBLN2 RNF122 PALLD	2.27e-05	191	132	6	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1D ZFPM2 KLHL29 FBLN2 NFIA ALDH1A3	2.34e-05	192	132	6	8d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLG5 CTC1 CCDC178 ZFPM2 PTPRM RNF122	2.55e-05	195	132	6	6a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MDM2 JAK1 AARS2 TESK2 PWWP3A MOCS1	2.63e-05	196	132	6	c57a95f8b4d8d6334f269d3c16246684f4222a3e
ToppCell	distal-Endothelial-Bronchial_Vessel_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VWF THSD7A CCDC178 FBLN2 CDA C7	2.70e-05	197	132	6	f45a93b5ad80a16b760acbaa6467648ffc05a0d3
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDCD2 CCDC178 CDA TNFAIP3 NUDCD1 C7	2.70e-05	197	132	6	ec92d60f802c9d4bdf9877bed5c0a91a5a5ed5d0
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PDCD2 CCDC178 CDA TNFAIP3 NUDCD1 C7	2.70e-05	197	132	6	7bec9c1bc8851064eb229324493b47a31201c83c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KDM5B FEZF2 ZFPM2 NFIA RNF24 ZBTB18	2.78e-05	198	132	6	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KDM5B FEZF2 ZFPM2 NFIA RNF24 ZBTB18	2.78e-05	198	132	6	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CACNA1D THSD7A GDF10 ZFPM2 NFIA C7	2.78e-05	198	132	6	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CPAMD8 VWF THSD7A GAS2L1 FBLN2 PTPRM	2.86e-05	199	132	6	bd43a84e84d8acb8e1008b98a235cc5bd5f43586
ToppCell	distal-2-Endothelial-Artery\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CPAMD8 VWF THSD7A FBLN2 PTPRM PALLD	2.86e-05	199	132	6	fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCell	cellseq-Mesenchymal-Fibroblastic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1D MYOC GDF10 FBLN2 C7 PALLD	2.94e-05	200	132	6	8978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCell	normal_Lung-Fibroblasts\|normal_Lung / Location, Cell class and cell subclass	MYOC GDF10 FBLN2 NFIA C7 PALLD	2.94e-05	200	132	6	803cf7f1382d07220249029cd220233232027689
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Mesothelial-2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CBR3 FBLN2 SLPI SMO ALDH1A3 PALLD	2.94e-05	200	132	6	b33901d91b3af5c0cf310eede30ce03af90c9783
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CBR3 FBLN2 SLPI SMO ALDH1A3 PALLD	2.94e-05	200	132	6	23bc13983f6bdf95e63109b8bc14c4921ca85c3a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VWF THSD7A FBLN2 PTPRM ALDH1A3 PALLD	2.94e-05	200	132	6	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CBR3 FBLN2 SLPI SMO ALDH1A3 PALLD	2.94e-05	200	132	6	d276062545ecc428a28b12a74f06f3c6bbcff4a3
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF THSD7A FBLN2 PTPRM ALDH1A3 PALLD	2.94e-05	200	132	6	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYH13 CCDC178 CDA OC90	3.69e-05	63	132	4	55f11bb2970a8159166e71af34a0446ecee594e6
ToppCell	control-Epithelial-Secretory-diff\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PI3 SLPI TRIM63 MOCS1	5.28e-05	69	132	4	2c1eb6b358c323b4b6a642f473068681987a9e91
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DLG5 FEZF2 THSD7B ZFPM2 NFIA	6.33e-05	141	132	5	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	control-Epithelial-Secretory-diff\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PI3 SLPI TRIM63 MOCS1	6.59e-05	73	132	4	dded04580ac197d3471a8ed43e1e61c56ee09f78
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH13 GRM1 PTPRM PRKN CDA	6.99e-05	144	132	5	71107275767a0728541a3695715c44874b3e5efc
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZFPM2 OTOGL PDE8B LPP MOCS1	9.02e-05	152	132	5	621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytotoxic_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DLG5 HIC2 CD200R1 GAS2L1 TESK2	9.31e-05	153	132	5	df2130689e53748e820a5835fa396fe82a5d2c7c
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	MYOC GDF10 RFPL4B FBLN2 NFIA	9.60e-05	154	132	5	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	MYOC GDF10 RFPL4B FBLN2 NFIA	9.60e-05	154	132	5	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF THSD7A CTC1 FBLN2 UBE2Z	9.89e-05	155	132	5	8e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-SMG_basal_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CPAMD8 PI3 SLPI ALDH1A3 PADI2	1.08e-04	158	132	5	adad97e6cf479d42791c5ba9cbc5f15f469322bf
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	NWD1 THSD7B ZFPM2 DNAH8 ALK	1.12e-04	159	132	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	droplet-Limb_Muscle-nan-24m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 SLPI C7 DEPDC1B SLC27A4	1.15e-04	160	132	5	984990be02642a562f0c60ea99c01f005e7c02c2
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	CERKL RFPL4B LRRTM2 SCUBE3 BSN	1.29e-04	164	132	5	362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCell	367C-Fibroblasts-Fibroblast-F\|367C / Donor, Lineage, Cell class and subclass (all cells)	RFPL4B FBLN2 SLPI CHRD IL17RD	1.36e-04	166	132	5	2887f4f0c218cbcbcc82eef27aa4ee714b35cddb
ToppCell	367C-Fibroblasts-Fibroblast-F-\|367C / Donor, Lineage, Cell class and subclass (all cells)	RFPL4B FBLN2 SLPI CHRD IL17RD	1.36e-04	166	132	5	1cc291a04f4144abba4aca7badeb7776db05d903
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 CTC1 ZFPM2 MSH6 TESK2	1.40e-04	167	132	5	961e722442d786ab15d1e490941d2be265a9057a
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 CTC1 ZFPM2 MSH6 TESK2	1.40e-04	167	132	5	3760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE8B SLPI CHRD C7 PALLD	1.48e-04	169	132	5	6ff1172da690ca17f7108f1617b255b766971a57
ToppCell	severe-Myeloid-Eosinophils\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CACNA1D IKZF2 THSD7A CD200R1 TMEM164	1.52e-04	170	132	5	863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAP70 JAK1 PADI2 DEPDC1B PPM1N	1.57e-04	171	132	5	f12c2e48637b96557afbc2006a3a23ba21b7951e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAP70 JAK1 PADI2 DEPDC1B PPM1N	1.57e-04	171	132	5	12c98dea7370377695c5d22309f78ba03e282a0e
ToppCell	droplet-Lung-nan-21m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 NWD1 CD200R1 TNFAIP3 PADI2	1.61e-04	172	132	5	1b133be191252e7053faeacf9547730c3ae28d21
ToppCell	droplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 SLPI TNFAIP3 RNF24 SLC27A4	1.61e-04	172	132	5	6ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM54 PCARE CR1 ZFPM2 KLHL29	1.61e-04	172	132	5	6c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCell	droplet-Lung-nan-21m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE2 NWD1 CD200R1 TNFAIP3 PADI2	1.61e-04	172	132	5	b3c53fd7e50f36de6a8585ae21d04e17932f262c
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	KIF4A PDE8B CHRD DEPDC1B MOCS1	1.65e-04	173	132	5	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	droplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPNE2 IKZF2 CD200R1 TNFAIP3 PADI2	1.65e-04	173	132	5	120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERKL LPAR3 GDF10 LRRTM2 C7	1.65e-04	173	132	5	c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 CD200R1 AARS2 BSN PADI2	1.65e-04	173	132	5	3612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCell	droplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPNE2 IKZF2 CD200R1 TNFAIP3 PADI2	1.65e-04	173	132	5	b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 CD200R1 AARS2 BSN PADI2	1.65e-04	173	132	5	4dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF2 ZAP70 TNFAIP3 DNAH8 PPM1N	1.79e-04	176	132	5	feafc757e7aa4f17128ff34886beb2fd3461c9ea
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PTPRM LPP IL17RD DNAH8	1.79e-04	176	132	5	7292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CPAMD8 VWF FBLN2 PTPRM LTBP3	1.79e-04	176	132	5	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PTPRM LPP IL17RD DNAH8	1.79e-04	176	132	5	88ca2f83d8301633232735f39b0683efe49d0b86
ToppCell	356C-Endothelial_cells-Endothelial-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	VWF THSD7A CCDC178 LRRTM2 C7	1.84e-04	177	132	5	a0b172f40e0df97a288a5549ae7066697ad469b3
ToppCell	LPS_only-Lymphocytic_B-B_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND5B GGA2 CR1 CR2 NCKAP1L	1.84e-04	177	132	5	c82332c5f656aa26513e4f7525d5d4d733019725
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK14 PI3 PDE8B SLPI ALDH1A3	1.84e-04	177	132	5	779ba86f53650772755b52460be03f18bb204e55
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK14 PI3 PDE8B SLPI ALDH1A3	1.84e-04	177	132	5	0f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell	LPS_only-Lymphocytic_B\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND5B GGA2 CR1 CR2 NCKAP1L	1.84e-04	177	132	5	5ed65e08d773d157840317c72e0d43c261d438d4
ToppCell	LPS_only-Lymphocytic_B-B_cells-B-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND5B GGA2 CR1 CR2 NCKAP1L	1.84e-04	177	132	5	8a955a7ab84c434f9ad4b467246b8be3cb479406
ToppCell	356C-Endothelial_cells-Endothelial-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	VWF THSD7A CCDC178 LRRTM2 C7	1.84e-04	177	132	5	ab8f09e118e4df696b0b4d33f013da020bdbd351
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DENND5B VWF THSD7A FZD9 FBLN2	1.89e-04	178	132	5	0139b42494c1186390b12106dea7957e2b6717c2
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF DPY19L4 TMEM164 RNF122 PADI2	1.89e-04	178	132	5	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	Globus_pallidus-Macroglia\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GJB1 TESK2 SLPI RNF122 PADI2	1.94e-04	179	132	5	ab50f711b004b96107f813c9a2526ec21d1c8027
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRIM54 PCARE CR1 ZFPM2 KLHL29	1.94e-04	179	132	5	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	POLR2L CBR3 PI3 SLPI ALDH1A3	1.94e-04	179	132	5	ec331b1132f965581f851a3b29e62873c4140e6c
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ZAP70 ZFPM2 KLHL29 PADI2 ALK	1.94e-04	179	132	5	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D CCDC178 THSD7B SCUBE3 DEPDC1B	1.94e-04	179	132	5	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CPAMD8 VWF THSD7A FBLN2 PTPRM	1.94e-04	179	132	5	2a53d94f6c30bf887dfe88f1693ea057218c852d
Drug	Enoxacin [74011-58-8]; Up 200; 12.4uM; PC3; HT_HG-U133A	DLG5 FLT4 MYOC APC HIC2 GAS2L1 PI3 PRKN TNFAIP3 MOCS1	2.28e-07	198	131	10	4655_UP
Drug	Ethylnitrosourea	MYOC APC MDM2 ZAP70 ZFPM2 JAK1 MSH6 GJB1 PRKN SMO ALK	1.00e-06	291	131	11	ctd:D005038
Drug	2-fluoroadenine arabinoside	VWF MDM2 CR2 ZAP70 NR1H2 CDA TNFAIP3 NCKAP1L	3.78e-06	158	131	8	CID000003367
Drug	tungstopterin	IKZF2 VWF APC2 APC MDM2 MSH6 SMO	1.10e-05	131	131	7	CID005460240
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	DENND5B HIC2 MDM2 PTPRM PDE8B RNF122 RNF24 PALLD	1.70e-05	194	131	8	4134_DN
Drug	Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; PC3; HT_HG-U133A	GGA2 MYOC GRM1 MDM2 ZFPM2 LPP TNFAIP3 ALK	1.90e-05	197	131	8	4285_UP
Drug	Propafenone hydrochloride [34183-22-7]; Up 200; 10.6uM; HL60; HG-U133A	SFMBT1 GGA2 MYOC CDCP1 CR1 PI3 SLPI PWWP3A	2.12e-05	200	131	8	1722_UP
Disease	Glaucoma	CPAMD8 MYOC TDRD7	7.04e-06	9	131	3	C0017601
Disease	familial adenomatous polyposis 1 (implicated_via_orthology)	APC2 APC	1.96e-05	2	131	2	DOID:0080409 (implicated_via_orthology)
Disease	Colorectal Carcinoma	OMA1 CPAMD8 APC2 APC GRM1 HPS3 MSH6 FBLN2 INTS13 DIP2C TMEM164 DNAH8	7.21e-05	702	131	12	C0009402
Disease	elafin measurement	PI3 SLPI	1.17e-04	4	131	2	EFO_0008117
Disease	Severe intellectual disability and progressive spastic paraplegia	AP4E1 AP4B1	1.17e-04	4	131	2	C4755264
Disease	Intellectual Disability	APC2 APC KIF4A CHD8 AP4E1 NFIA ZNF335 KLHL15 PJA1	1.80e-04	447	131	9	C3714756
Disease	Turcot syndrome (disorder)	APC MSH6	1.94e-04	5	131	2	C0265325
Disease	response to iloperidone	CERKL PALLD	2.90e-04	6	131	2	GO_0036287
Disease	ovarian cancer (implicated_via_orthology)	APC MSH6	5.38e-04	8	131	2	DOID:2394 (implicated_via_orthology)
Disease	Adenoma, Microcystic	CACNA1D APC GJB1	5.49e-04	36	131	3	C0205648
Disease	Adenoma, Monomorphic	CACNA1D APC GJB1	5.49e-04	36	131	3	C0205649
Disease	Adenoma, Basal Cell	CACNA1D APC GJB1	5.49e-04	36	131	3	C0205646
Disease	Follicular adenoma	CACNA1D APC GJB1	5.49e-04	36	131	3	C0205647
Disease	Papillary adenoma	CACNA1D APC GJB1	5.49e-04	36	131	3	C0205650
Disease	Adenoma, Trabecular	CACNA1D APC GJB1	5.49e-04	36	131	3	C0205651
Disease	Adenoma	CACNA1D APC GJB1	5.49e-04	36	131	3	C0001430
Disease	endometrial cancer (is_implicated_in)	APC JAK1 MSH6	5.49e-04	36	131	3	DOID:1380 (is_implicated_in)
Disease	Lynch Syndrome	APC MSH6	6.90e-04	9	131	2	C4552100
Disease	kallikrein-14 measurement	KLK14 C7	6.90e-04	9	131	2	EFO_0020513
Disease	insulin sensitivity measurement, glucose homeostasis measurement	LPAR3 LPP ALK	9.27e-04	43	131	3	EFO_0004471, EFO_0006896
Disease	Alcoholic Intoxication, Chronic	VWF THSD7B GRM1 PHF3 TESK2 ALK	1.29e-03	268	131	6	C0001973
Disease	sitting height ratio	KLHL29 JAK1 PTPRM	1.52e-03	51	131	3	EFO_0007118
Disease	open-angle glaucoma	THSD7A MYOC ZFPM2 LPP LTBP3	1.66e-03	191	131	5	EFO_0004190
Disease	pancreatic ductal carcinoma (is_implicated_in)	MDM2 SMO	2.25e-03	16	131	2	DOID:3587 (is_implicated_in)
Disease	Tetralogy of Fallot	FLT4 ZFPM2	2.25e-03	16	131	2	C0039685
Disease	ocular hypertension (biomarker_via_orthology)	MYOC SMO	2.55e-03	17	131	2	DOID:9282 (biomarker_via_orthology)
Disease	Neoplastic Cell Transformation	APC MDM2 TNFAIP3 ALK	3.48e-03	139	131	4	C0007621
Disease	platelet crit	VWF MYH13 ZFPM2 KLHL29 JAK1 NFIA TESK2 ARIH2 CHRD PJA1 UBE2Z	3.52e-03	952	131	11	EFO_0007985
Disease	coagulation factor measurement	VWF CFHR5	3.53e-03	20	131	2	EFO_0004634
Disease	Osteoarthritis of hip	SMO LTBP3	3.53e-03	20	131	2	C0029410
Disease	Sarcoma	FLT4 MDM2	3.89e-03	21	131	2	C1261473
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	VWF ZFPM2	3.89e-03	21	131	2	EFO_0004286, EFO_0004792
Disease	severe acute respiratory syndrome, COVID-19	OMA1 IKZF2 THSD7A CCDC178 ZFPM2 NFIA LTBP3	3.90e-03	447	131	7	EFO_0000694, MONDO_0100096
Disease	psychotic symptoms	OMA1 KLHL29 DIP2C	4.41e-03	74	131	3	EFO_0005940

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPPVKQELVSCKMCR	ATP6V1FNB	141	A0A1B0GUX0
IREVNGIKPFACPCK	BHLHB9	301	Q6PI77
VAMCRQVCRLPPAAG	CHD8	1851	Q9HCK8
PMGPQYCVCKVELSV	CPNE2	16	Q96FN4
CHKEALMKRNFCVPP	CTC1	736	Q2NKJ3
IEIQKNIDCMSGPCP	CDCP1	91	Q9H5V8
LAPALCCGNTMVLKP	ALDH1A3	191	P47895
CKDCSDPNPMVRGLA	AP4B1	91	Q9Y6B7
RICLNKEMPPLCDGF	DEPDC1B	336	Q8WUY9
QLCPGADCPMVIRVQ	ARIH2	226	O95376
NFKVTEQPGCCLPVM	AP4E1	966	Q9UPM8
ICIPPPEARKAINCM	NWD1	1291	Q149M9
PCCVLSNPDQKGKMR	NFIA	101	Q12857
CPPNCPDEVYQLMRK	JAK1	1116	P23458
QRVLECLMACRSKPP	INTS13	551	Q9NVM9
IVDPKEMPCFCLRHD	NUDCD1	446	Q96RS6
GMACPPKCRCEKLLF	LRRTM2	31	O43300
VMCKPGPESDFCLKV	IL17RD	591	Q8NFM7
CQKAYPRTITPGMVC	KLK14	191	Q9P0G3
SPLMPKGATCFECNI	ZFPM2	541	Q8WW38
KTMPKERAICPLCQA	BSN	456	Q9UPA5
CAVVNIPAPCVNKMI	CCDC178	86	Q5BJE1
ILVLCCGAMSPPQLA	FETUB	11	Q9UGM5
PCCVPDKMNSLGVLF	GDF10	441	P55107
CCVVGTLFKAMPLQP	POLD2	91	P49005
KISCQFMLCPELPPN	FBLN2	106	P98095
CPCGAKRILEFQVMP	PDCD2	281	Q16342
MIKCADVANPCRPLD	PDE8B	776	O95263
DPCRSFKPQICEMIV	DNAH8	2616	Q96JB1
LDNMTCILVCFPGAP	PPM1N	316	Q8N819
PGKFCRCPLEVMKAS	DLG5	1761	Q8TDM6
MLFVRIKPSLVCCEG	KBTBD2	366	Q8IY47
ARCCSFGPEMPAVQL	MYOC	6	Q99972
SHCPFLMGPIECLKE	NCKAP1L	931	P55160
KFAPRCSVCKEPIMP	LPP	531	Q93052
KMICCFSQENPERRP	LPAR3	306	Q9UBY5
TPGCPIFYCLQDIMR	KRIT1	126	O00522
VKMATNAVLCCPPIA	CD200R1	51	Q8TD46
VFQNPAGCMKTCPLI	GGA2	336	Q9UJY4
TKPGSCPIILIRCAM	PI3	71	P19957
IRCAMLNPPNRCLKD	PI3	81	P19957
IKICLCQKAPAAPMI	KDM5B	1176	Q9UGL1
RAMCPLCRDVVKVPA	RFPL4B	46	Q6ZWI9
PNILPPVSVFVCCMK	PADI2	301	Q9Y2J8
MGCYVPAEVCRLTPI	MSH6	1156	P52701
PQLGEMLFCLTSRCP	OC90	306	Q02509
RLPNGKLKCDVCGMV	IKZF2	106	Q9UKS7
NLRCQYCMPEEGVPL	MOCS1	81	Q9NZB8
LCRMDCKVSGLPTPD	PALLD	1151	Q8WX93
CPLCPKAFPLQRMLT	OVOL3	96	O00110
AAPCQAVEIPMCRGI	FZD9	36	O00144
PIEPQICQATCAVMK	APC2	406	O95996
PRMPCKLDGLQVCNL	KLHL15	576	Q96M94
FMEIRLCKEITCPPP	CR2	516	P20023
CQPGFVMKGPRRVKC	CR1	266	P17927
CQPGFVMKGPRRVKC	CR1	716	P17927
CQPGFVMKGPRRVKC	CR1	1166	P17927
LCGKISFELMREPCI	STUB1	231	Q9UNE7
LGRCTCPDQFPMIKV	GAS2L1	216	Q99501
LKPFCCGITNMSFPL	CPAMD8	181	Q8IZJ3
CQKIACVLPVLMDGI	C7	626	P10643
AICNEVGPMRGCRVK	DPY19L4	646	Q7Z388
AIMCSVKPDGVPQLC	DIP2C	711	Q9Y2E4
SICLITPLPFMQACK	DENND5B	191	Q6ZUT9
MAIPCLCSVAPRGLA	CERKL	431	Q49MI3
AMVRLVKCDVYPCPN	GJB1	161	P08034
PKCLRMCSFPFVKNG	CFHR5	81	Q9BXR6
GIAVVAVMCKPHRCP	ELP3	86	Q9H9T3
GEPEMCVAALCERPQ	DGCR2	301	P98153
SGFRVVVCPLPCMNG	LTBP3	106	Q9NS15
ILVNACCPGPVKTDM	CBR3	221	O75828
AQMPTPKAIDCRKCF	DENND4B	1476	O75064
CRPLVPKEISEGCQM	KIF4A	16	O95239
CRPLVPKEISEGCQM	KIF4B	16	Q2VIQ3
QKPICDPDTGMCRCR	LAMB4	1136	A4D0S4
RLPATSCVGFVCQPM	KRTAP29-1	71	A8MX34
LPKARVVVCFCEGMT	GRM1	281	Q13255
TCPVGFMLQPDRKTC	SCUBE3	261	Q8IX30
IMLACLPGKLCDPES	CACNA1D	1411	Q01668
PGIEDNMLCPDCAKR	DPPA2	271	Q7Z7J5
MPVHTGARPFVCKVC	FEZF2	296	Q8TBJ5
VEGCLPYCPKNMILD	OTOGL	1401	Q3ZCN5
KNRCMDILPPDRCLP	PTPRM	1216	P28827
KDAGASPCLRNCIMP	PCARE	751	A6NGG8
RPFPCNICGKMFTQR	HIC2	531	Q96JB3
VGCPLGQRQPCRKML	PWWP3A	546	Q2TAK8
IFMVPVACGLFPQKC	SFXN2	276	Q96NB2
EECVLQMGGVLCPRP	PRKN	321	O60260
PPNFCEMDGQCKRDL	SLPI	101	P03973
CDPEEMPLGSRVCKL	THSD7A	1146	Q9UPZ6
EMILRKPEPGLFCCA	TDRD15	526	B5MCY1
ACPPVSMDVCALRIQ	HPS3	416	Q969F9
GLPHCMVIVRACPKE	FBXL12	306	Q9NXK8
GPAPKMLGHELCRVC	NR1H2	76	P55055
RNKPCPVCRQPIQMI	MDM2	471	Q00987
KCCKLIPVMLGGVFI	SLC35B3	176	Q9H1N7
VRKVCPLCNMPVLQL	RNF24	111	Q9Y225
MIAIPPQAIKCCLAD	TDRD7	761	Q8NHU6
FPGLCLICAMGVEPI	SLC38A8	386	A6NNN8
ALKIREMCNCPPLSN	OMA1	456	Q96E52
SPQPMGKVLCACQVA	AARS2	916	Q5JTZ9
CEVPQRLLEMACGDP	STK36	1231	Q9NRP7
PKNCPGPVYRIMTQC	ALK	1351	Q9UM73
PVEHQICPAVCVLMK	APC	441	P25054
MAQKRPACTLKPECV	CDA	1	P32320
PDLGEPFGVMRCVLC	CHRD	66	Q9H2X0
CLEMFTKPVVILPCQ	TRIM63	26	Q969Q1
CGETAFIAPQCEMIP	PAICS	81	P22234
EGRCPLMLTECPACK	TRAF2	126	Q12933
CPICLEMFSKPVVIL	TRIM54	26	Q9BYV2
GKPILCPIMHCNKEF	ZNF451	166	Q9Y4E5
FIEQGKRMECPPECP	ZAP70	551	P43403
SCRPPMVKLVCPADN	VWF	766	P04275
MKCRSPGCPFTLNVQ	TNFAIP3	476	P21580
VRCVCPMCNKPIASP	RNF122	126	Q9H9V4
MELIRGPDGVCIPCQ	SLC27A4	426	Q6P1M0
CPPCRGAIVVFKLQM	TMEM164	136	Q5U3C3
LLPNVCAFPMEKGPC	SPINT3	31	P49223
AGQIFMCPLCNKVFP	ZBTB18	366	Q99592
CTKPQGPLMVIVEFC	FLT4	916	P35916
MVPPDKCRCAVGSIL	TEX264	86	Q9Y6I9
EMLKGLCCPRVKVGN	MYH13	396	Q9UKX3
LNCKICIGRMAPPVD	PHF3	1116	Q92576
KVVCFRLAVGPCLME	SLC9B1	181	Q4ZJI4
MIIPVRCFTCGKIVG	POLR2L	1	P62875
KPFAGRPMIECSLCG	PHF23	346	Q9BUL5
VIQPLLCAVYMPKCE	SMO	121	Q99835
CPCPEPLRGVMEKSF	UBE2Z	261	Q9H832
RPFKCDLCPMGFKQQ	ZNF319	341	Q9P2F9
KLECCPNLFGPRMVL	SFMBT1	606	Q9UHJ3
APMAQKLPTCRECGK	ZNF18	401	P17022
GMPLLVQECTVPCRE	THSD7B	856	Q9C0I4
CCNMDPKLRPSFVEI	TESK2	291	Q96S53
ICELMPCLPKEGIFA	TRIP12	731	Q14669
SFPCPVCGRVYPMQK	ZNF335	561	Q9H4Z2
LQKSGTCPVCRCMFP	PJA1	626	Q8NG27
MPCPVFRHGCVVIKK	KLHL29	856	Q96CT2