Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	4.81e-04	14	49	2	GO:0060091
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	4.81e-04	14	49	2	GO:0097732
GeneOntologyCellularComponent	GBAF complex	BICRA SMARCA4	4.81e-04	14	49	2	GO:0140288
GeneOntologyCellularComponent	stereocilium tip	STRC STRCP1	1.21e-03	22	49	2	GO:0032426
Domain	FH2	FMN1 DAAM2	5.84e-04	15	45	2	PS51444
Domain	FH2_Formin	FMN1 DAAM2	5.84e-04	15	45	2	IPR015425
Domain	FH2	FMN1 DAAM2	5.84e-04	15	45	2	PF02181
Domain	FH2	FMN1 DAAM2	5.84e-04	15	45	2	SM00498
Domain	TNFR_c6	TNFRSF1B TNFRSF21	1.27e-03	22	45	2	PF00020
Domain	TNFR	TNFRSF1B TNFRSF21	1.78e-03	26	45	2	SM00208
Domain	TNFR_NGFR_1	TNFRSF1B TNFRSF21	2.21e-03	29	45	2	PS00652
Domain	TNFR_NGFR_2	TNFRSF1B TNFRSF21	2.21e-03	29	45	2	PS50050
Domain	TNFR/NGFR_Cys_rich_reg	TNFRSF1B TNFRSF21	2.86e-03	33	45	2	IPR001368
Domain	GDS_CDC24_CS	TRIO ARHGEF15	3.97e-03	39	45	2	IPR001331
Pubmed	Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation.	GATA1 SMARCA4	2.11e-06	2	51	2	17438135
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	2.11e-06	2	51	2	11687802
Pubmed	Eosinophils are required for the maintenance of plasma cells in the bone marrow.	TNFSF13 GATA1	2.11e-06	2	51	2	21217761
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	2.11e-06	2	51	2	34910522
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	6.32e-06	3	51	2	30801007
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.26e-05	4	51	2	18849963
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	2.10e-05	5	51	2	24920589
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	GATA1 STRC STRCP1	2.42e-05	38	51	3	38346162
Pubmed	The TNF and TNF receptor superfamilies: integrating mammalian biology.	TNFSF13 TNFRSF1B TNFRSF21	2.62e-05	39	51	3	11239407
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	5.87e-05	8	51	2	21165971
Pubmed	Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.	GATA1 SMARCA4	7.54e-05	9	51	2	21245044
Pubmed	Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.	FMN1 CHRD	9.42e-05	10	51	2	10524628
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	BCL9L IGF2BP3 LRFN1 PIM2 NACA SMARCA4 ARHGEF15	1.11e-04	754	51	7	35906200
Pubmed	Functional selectivity of recombinant mammalian SWI/SNF subunits.	GATA1 SMARCA4	1.15e-04	11	51	2	11018012
Pubmed	Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.	AMOTL1 MESP1	1.15e-04	11	51	2	28239148
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	1.15e-04	11	51	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	1.15e-04	11	51	2	31776257
Pubmed	Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.	TRIO TENT4A	1.38e-04	12	51	2	23776197
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	FMN1 DAAM2	1.90e-04	14	51	2	26272686
Pubmed	A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.	BICRA SMARCA4	1.90e-04	14	51	2	30510198
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SCAF1 LRFN1 TRIO ADAMTS7 BICRA ZNF395 SSBP4 TNFRSF21	1.92e-04	1105	51	8	35748872
Pubmed	Chromatin remodelling complex dosage modulates transcription factor function in heart development.	GATA1 SMARCA4	2.83e-04	17	51	2	21304516
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	2.83e-04	17	51	2	20856818
Pubmed	High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.	BNC2 GATA1 SMARCA4	3.62e-04	94	51	3	16325481
Pubmed	Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population.	TNFRSF1B TNFRSF21	4.78e-04	22	51	2	15301860
Pubmed	Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.	GATA1 RXRB	4.78e-04	22	51	2	16024815
Pubmed	Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.	BICRA SMARCA4	7.23e-04	27	51	2	29374058
Pubmed	Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.	SMARCA4 TFG	7.78e-04	28	51	2	30037996
Pubmed	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.	BICRA SMARCA4	8.35e-04	29	51	2	19279220
Pubmed	Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.	GATA1 ZNF395	8.35e-04	29	51	2	23565059
Pubmed	c-Jun is required for the specification of joint cell fates.	GATA1 CHRD	9.54e-04	31	51	2	23475960
Pubmed	Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.	FMN1 SMARCA4	1.02e-03	32	51	2	31815296
Pubmed	Human transcription factor protein interaction networks.	BCL9L IGF2BP3 ERF BICRA NACA GATA1 SMARCA4 SSBP4	1.05e-03	1429	51	8	35140242
Pubmed	A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation.	PIM2 GATA1	1.15e-03	34	51	2	10857745
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	BCL9L SMARCA4	1.15e-03	34	51	2	30894540
Pubmed	Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.	CHRD MESP1	1.22e-03	35	51	2	25977363
Pubmed	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.	GATA1 SMARCA4	1.22e-03	35	51	2	22325351
Pubmed	The transcription factor XBP1 is selectively required for eosinophil differentiation.	SEC24D GATA1	1.36e-03	37	51	2	26147683
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	BCL9L TRIO AMOTL1 SMARCA4	1.43e-03	332	51	4	37433992
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	TRIO ARHGEF15	1.43e-03	38	51	2	19911011
Cytoband	15q15.3	STRC STRCP1	3.57e-04	25	51	2	15q15.3
Cytoband	15q26.1	AEN MESP1	1.67e-03	54	51	2	15q26.1
Cytoband	19p13.2	PRR36 SMARCA4 SWSAP1	2.14e-03	229	51	3	19p13.2
GeneFamily	CD molecules\|Tumor necrosis factor receptor superfamily\|Death inducing signaling complex	TNFRSF1B TNFRSF21	9.15e-04	29	28	2	782
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO ARHGEF15	4.67e-03	66	28	2	722
Coexpression	GSE22886_CD8_VS_CD4_NAIVE_TCELL_DN	MYO15B PIM2 TENT4A GORASP1 SCNN1A SH2B1	1.96e-06	196	50	6	M4404
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 STARD8 FMN1 DAAM2 TNFRSF21	2.56e-06	190	51	5	2d54fca50593fbd11fe13fc2bfaf937a05db776d
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; PC3; HT_HG-U133A	RIN1 SEC24D ERF PIM2 TRIO RUSC2	4.23e-06	199	49	6	4531_DN
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	2.81e-06	2	50	2	DOID:0110471 (implicated_via_orthology)
Disease	stroke, coronary artery disease	ADAMTS7 SMARCA4	5.79e-04	21	50	2	EFO_0000712, EFO_0001645
Disease	cigarettes per day measurement	ADAMTS7 TEX29 CHRNA3 SH2B1 SEZ6	8.62e-04	438	50	5	EFO_0006525
Disease	Sezary Syndrome	SMARCA4 TNFRSF1B	9.61e-04	27	50	2	C0036920
Disease	velopharyngeal dysfunction	BNC2 FMN1 CHRNA3	1.17e-03	122	50	3	EFO_0009336
Disease	Age-related nuclear cataract	LINC00322 BICRA	1.27e-03	31	50	2	HP_0011142
Disease	visual epilepsy (implicated_via_orthology)	TNFRSF1B CHRNA3	1.52e-03	34	50	2	DOID:11832 (implicated_via_orthology)
Disease	lung adenocarcinoma	LRFN1 ADAMTS7 CHRNA3	3.22e-03	174	50	3	EFO_0000571
Disease	triglycerides to total lipids in medium LDL percentage	TENT4A SMARCA4	3.27e-03	50	50	2	EFO_0022334

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLLSMPPEPGSSPLP	AEN	51	Q8WTP8
PGSLLPPQLSPALPM	ERF	256	P50548
PAPPIPIPTLSLMGG	C8orf44	11	Q96CB5
MGSGPLSLPLALSPP	CHRNA3	1	P32297
LTSPGRPPMGFTTPP	BNC2	531	Q6ZN30
SLPLPLPMALGAPQP	AMOTL1	406	Q8IY63
PKPSGSPCTPLLPMA	ARHGEF15	121	O94989
MPGGPSPRSPAPLLR	ADAMTS7	1	Q9UKP4
LPSGLGSLSPAPPMP	FMN1	881	Q68DA7
GSLSPAPPMPPVSAG	FMN1	886	Q68DA7
SPPPPGGPLTLSSSM	DAAM2	521	Q86T65
MAPGPFSSALLSPPP	LRFN1	1	Q9P244
PMLPLGPSGPVGPTS	PCOTH	86	Q58A44
PGSSMEDPLPGPGSP	GORASP1	261	Q9BQQ3
NALGLFPPTSGMPPP	IGF2BP3	371	O00425
GLPTALPMPSGKPQP	TENT4A	626	Q5XG87
SSPPMLSPSPGKGPP	MYO15B	1136	Q96JP2
LLGSPTGSFPTGPMP	GATA1	386	P15976
LLGDPAPPLSGPMAP	HDAC10	321	Q969S8
PPPLALLMGTLSPGL	LINC00322	106	Q6ZN03
RMGPADSLPPTPPSG	CCDC102A	31	Q96A19
PPAMLPSPTPLGSNI	BCL9L	1171	Q86UU0
APAPAPMAATGLPPL	BICRA	1016	Q9NZM4
PMSLSLSQPGPAPSP	SCNN1A	621	P37088
PAFPGMVPASLPGPS	OTP	271	Q5XKR4
PLGPGMDLLGPDPSP	RUSC2	601	Q8N2Y8
PATSPRPMTLPLAPG	SH2B1	381	Q9NRF2
RVPAGSGPSLPPMPS	RIN1	296	Q13671
LPMSPSPLSPSPIPS	TNFRSF21	511	O75509
PGGLSPLSPSPPMGA	NKX1-1	381	Q15270
MLTKPLQGPPAPPGT	PIM2	1	Q9P1W9
PPLSAMSPLQGPVSP	PRR36	456	Q9H6K5
MSTPDPPLGGTPRPG	SMARCA4	1	P51532
MPAAGPPLLLLGTPG	SWSAP1	1	Q6NVH7
GQAMEPSPPSPLLPG	MESP1	231	Q9BRJ9
PPSSLGLPIPLMSGK	NPAP1	286	Q9NZP6
PSPLCLTPGPFLLGM	STRC	586	Q7RTU9
PMGSSDLLAPPSPGL	STARD8	46	Q92502
TTLNGPGASPLPLPM	SEC24D	176	O94855
ISSSMGSPGLPPPAP	RXRB	136	P28702
MPSLPAPPAPLLLLG	CHRD	1	Q9H2X0
PGFTSLPGSTMTPPP	TFG	361	Q92734
MTPAPVPTSLGLPPG	SCAF1	1146	Q9H7N4
PGSQPLLPGAMEPSP	SSBP4	171	Q9BWG4
TPSMTGLPLSALPPP	ZNF395	356	Q9H8N7
SPMLRITAPLPPGPS	SEZ6	146	Q53EL9
PSPLCLTPGPFLLGM	STRCP1	586	A6NGW2
APSTSFLLPMGPSPP	TNFRSF1B	236	P20333
LKPASPGPPSAGPSM	TEX29	116	Q8N6K0
MPASSPFLLAPKGPP	TNFSF13	1	O75888
MSGTSTPGPSLPPPG	TRIO	2366	O75962
GPAMTPPSPKRGPAI	NACA	1381	E9PAV3