Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A18 RHCG ABCC4 ABCA4 CATSPER1 ATP8A1 TRPM3 SLC16A2 SLC6A16 SLC35C1 COX4I1 SLC6A17 SLC5A6 TRPC6 SLC5A7 SLC35F6 MFSD9 SLC13A5 SV2C TRPV4 SLC6A15 CACNA1H OCA2 TMC5 AQP9 SLC5A2	1.75e-14	1180	72	26	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLC6A18 RHCG ABCC4 ABCA4 CATSPER1 ATP8A1 TRPM3 SLC16A2 SLC6A16 SLC35C1 COX4I1 SLC6A17 SLC5A6 TRPC6 SLC5A7 SLC35F6 MFSD9 SLC13A5 SV2C TRPV4 SLC6A15 CACNA1H OCA2 TMC5 AQP9 SLC5A2	1.38e-13	1289	72	26	GO:0005215
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A18 ABCC4 ABCA4 ATP8A1 SLC16A2 SLC6A16 SLC35C1 COX4I1 SLC6A17 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	1.37e-09	477	72	14	GO:0022804
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A18 RHCG ABCC4 CATSPER1 TRPM3 COX4I1 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H OCA2 AQP9 SLC5A2	8.97e-09	758	72	16	GO:0015318
GeneOntologyMolecularFunction	symporter activity	SLC6A18 SLC6A16 SLC6A17 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	6.70e-08	150	72	8	GO:0015293
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A18 SLC16A2 SLC6A16 SLC35C1 SLC6A17 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	1.05e-07	296	72	10	GO:0015291
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A18 CATSPER1 ATP8A1 TRPM3 COX4I1 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H OCA2 TMC5 SLC5A2	1.18e-07	793	72	15	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A18 RHCG CATSPER1 TRPM3 COX4I1 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	3.30e-07	627	72	13	GO:0022890
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A18 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	4.66e-07	81	72	6	GO:0015370
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A18 CATSPER1 ATP8A1 TRPM3 COX4I1 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	6.30e-07	664	72	13	GO:0008324
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A18 CATSPER1 TRPM3 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	8.16e-07	465	72	11	GO:0046873
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A18 SLC5A6 SLC5A7 SLC13A5 SLC6A15 CACNA1H SLC5A2	2.75e-06	171	72	7	GO:0015081
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A18 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	4.47e-06	119	72	6	GO:0015294
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A18 ATP8A1 COX4I1 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	1.26e-05	301	72	8	GO:0022853
GeneOntologyMolecularFunction	calcium channel activity	CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H	1.03e-04	129	72	5	GO:0005262
GeneOntologyMolecularFunction	channel activity	RHCG CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H OCA2 TMC5 AQP9	1.10e-04	525	72	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	RHCG CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H OCA2 TMC5 AQP9	1.11e-04	526	72	9	GO:0022803
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	EDEM3 GLA MANBA SMPD1 MYORG	1.73e-04	144	72	5	GO:0016798
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H	2.15e-04	151	72	5	GO:0015085
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC5A6 SLC13A5 SLC6A15	2.71e-04	35	72	3	GO:0005343
GeneOntologyMolecularFunction	alcohol transmembrane transporter activity	ABCC4 ABCA4	3.54e-04	8	72	2	GO:0015665
GeneOntologyMolecularFunction	amide transmembrane transporter activity	ABCC4 SLC5A6 AQP9	4.66e-04	42	72	3	GO:0042887
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	EDEM3 GLA MANBA MYORG	5.25e-04	103	72	4	GO:0004553
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	ABCC4 SLC16A2 SLC5A6 SLC13A5 SLC6A15	9.09e-04	207	72	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	ABCC4 SLC16A2 SLC5A6 SLC13A5 SLC6A15	9.29e-04	208	72	5	GO:0005342
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	ABCA4 ATP8A1	1.13e-03	14	72	2	GO:0140333
GeneOntologyMolecularFunction	monoatomic ion channel activity	CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H OCA2 TMC5	1.32e-03	459	72	7	GO:0005216
GeneOntologyMolecularFunction	mannosidase activity	EDEM3 MANBA	1.49e-03	16	72	2	GO:0015923
GeneOntologyMolecularFunction	flippase activity	ABCA4 ATP8A1	1.68e-03	17	72	2	GO:0140327
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	TRPV4 TMC5	1.89e-03	18	72	2	GO:0008381
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	ABCC4 ABCA4 AQP9	2.07e-03	70	72	3	GO:1901618
GeneOntologyMolecularFunction	neurotransmitter transmembrane transporter activity	SLC6A16 SLC6A15	2.58e-03	21	72	2	GO:0005326
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A18 SLC6A15	3.09e-03	23	72	2	GO:0005283
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC6A18 ABCC4 SLC5A6 OCA2	3.40e-03	171	72	4	GO:0015103
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC4 ABCA4 ATP8A1 COX4I1	3.92e-03	178	72	4	GO:0015399
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	ABCC4 SLC16A2 SLC5A6 SLC13A5 SLC6A15	4.13e-03	293	72	5	GO:0008514
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	ABCC4 SLC16A2 SLC5A6	4.22e-03	90	72	3	GO:0008028
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA4 ATP8A1	4.56e-03	28	72	2	GO:0140326
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A18 SLC6A15	4.89e-03	29	72	2	GO:0005416
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	ABCC4 SLC5A6	6.30e-03	33	72	2	GO:0072349
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A18 SLC16A2 SLC6A15	6.48e-03	105	72	3	GO:0015171
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC4 ABCA4 ATP8A1	7.18e-03	109	72	3	GO:0042626
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	ABCA4 SLC5A6	7.46e-03	36	72	2	GO:0090482
GeneOntologyMolecularFunction	monoatomic cation channel activity	CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H	7.95e-03	343	72	5	GO:0005261
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC6A18 ABCC4 CATSPER1 ATP8A1 P2RY1 TRPM3 SLC6A16 COX4I1 SLC6A17 SLC5A6 STIMATE TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H OCA2 TMC5 SLC5A2	2.19e-08	1374	71	20	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A18 ABCC4 CATSPER1 ATP8A1 TRPM3 SLC6A16 COX4I1 SLC6A17 SLC5A6 STIMATE TRPC6 SLC13A5 TRPV4 SLC6A15 CACNA1H OCA2 TMC5 SLC5A2	2.75e-08	1115	71	18	GO:0034220
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC6A18 RHCG CATSPER1 TRPM3 SLC6A16 COX4I1 SLC6A17 SLC5A6 STIMATE TRPC6 SLC13A5 TRPV4 SLC6A15 CACNA1H OCA2 SLC5A2	2.69e-07	1017	71	16	GO:0098660
GeneOntologyBiologicalProcess	sodium ion transport	SLC6A18 SLC6A16 SLC6A17 SLC5A6 SLC5A7 SLC13A5 SLC6A15 CACNA1H SLC5A2	4.23e-07	275	71	9	GO:0006814
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC6A18 RHCG CATSPER1 TRPM3 SLC6A16 COX4I1 SLC6A17 SLC5A6 STIMATE TRPC6 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	4.45e-07	922	71	15	GO:0098662
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC6A18 SLC6A16 SLC6A17 SLC5A6 SLC13A5 SLC6A15 CACNA1H SLC5A2	5.77e-07	208	71	8	GO:0035725
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC6A18 CATSPER1 ATP8A1 TRPM3 SLC6A16 COX4I1 SLC6A17 SLC5A6 STIMATE TRPC6 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	5.83e-07	942	71	15	GO:0098655
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC6A18 CATSPER1 ATP8A1 TRPM3 SLC6A16 COX4I1 SLC6A17 SLC5A6 STIMATE TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	1.49e-06	1157	71	16	GO:0006812
GeneOntologyBiologicalProcess	metal ion transport	SLC6A18 CATSPER1 TRPM3 SLC6A16 SLC6A17 SLC5A6 STIMATE TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 CACNA1H SLC5A2	6.57e-06	1000	71	14	GO:0030001
GeneOntologyBiologicalProcess	transport across blood-brain barrier	ABCC4 ATP8A1 SLC16A2 SLC6A17 SLC5A6	1.24e-05	87	71	5	GO:0150104
GeneOntologyBiologicalProcess	vascular transport	ABCC4 ATP8A1 SLC16A2 SLC6A17 SLC5A6	1.31e-05	88	71	5	GO:0010232
GeneOntologyBiologicalProcess	vascular process in circulatory system	ABCC4 ATP8A1 P2RY1 SLC16A2 SLC6A17 SLC5A6 TRPV4 NR3C1	2.35e-05	344	71	8	GO:0003018
GeneOntologyBiologicalProcess	neurotransmitter transport	SLC6A18 P2RY1 SLC6A16 SLC6A17 SLC5A7 SV2C SLC6A15	3.04e-05	259	71	7	GO:0006836
GeneOntologyBiologicalProcess	amino acid transport	SLC6A18 SLC16A2 SLC6A16 SLC6A17 SLC6A15 NR3C1	5.68e-05	195	71	6	GO:0006865
GeneOntologyBiologicalProcess	carboxylic acid transport	ABCC4 SLC16A2 SLC6A17 SLC5A6 SLC13A5 SLC6A15 NR3C1 AQP9	8.11e-05	410	71	8	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	ABCC4 SLC16A2 SLC6A17 SLC5A6 SLC13A5 SLC6A15 NR3C1 AQP9	8.39e-05	412	71	8	GO:0015849
GeneOntologyBiologicalProcess	circulatory system process	ABCC4 ATP8A1 P2RY1 SLC16A2 SLC6A17 SLC5A6 FSHR TRPV4 CACNA1H NR3C1	1.97e-04	733	71	10	GO:0003013
GeneOntologyBiologicalProcess	acetate ester metabolic process	FSHR SLC5A7	3.23e-04	8	71	2	GO:1900619
GeneOntologyBiologicalProcess	acetylcholine metabolic process	FSHR SLC5A7	3.23e-04	8	71	2	GO:0008291
GeneOntologyBiologicalProcess	organic anion transport	ABCC4 SLC16A2 SLC6A17 SLC5A6 SLC13A5 SLC6A15 NR3C1 AQP9	3.83e-04	515	71	8	GO:0015711
GeneOntologyBiologicalProcess	L-leucine transport	SLC6A17 SLC6A15	5.16e-04	10	71	2	GO:0015820
GeneOntologyCellularComponent	secretory vesicle	MPO ABCC4 MOSPD2 ATP8A1 GLA MANBA SLC6A17 SPATA16 SLC5A7 SV2C SMPD1 CACFD1 EPX CTSA DGAT1 ARMC8	5.81e-06	1246	74	16	GO:0099503
GeneOntologyCellularComponent	apical plasma membrane	SLC6A18 RHCG ABCC4 P2RY1 SLC16A2 SLC5A6 SLC5A7 TRPV4 SLC5A2	5.42e-05	487	74	9	GO:0016324
GeneOntologyCellularComponent	secretory granule	MPO ABCC4 MOSPD2 ATP8A1 GLA MANBA SPATA16 SMPD1 EPX CTSA DGAT1 ARMC8	2.16e-04	1014	74	12	GO:0030141
GeneOntologyCellularComponent	apical part of cell	SLC6A18 RHCG ABCC4 P2RY1 SLC16A2 SLC5A6 SLC5A7 TRPV4 SLC5A2	2.37e-04	592	74	9	GO:0045177
GeneOntologyCellularComponent	azurophil granule	MPO ATP8A1 GLA MANBA CTSA	2.60e-04	160	74	5	GO:0042582
GeneOntologyCellularComponent	primary lysosome	MPO ATP8A1 GLA MANBA CTSA	2.60e-04	160	74	5	GO:0005766
GeneOntologyCellularComponent	lysosomal lumen	GLA MANBA SMPD1 CTSA	4.06e-04	98	74	4	GO:0043202
GeneOntologyCellularComponent	vacuolar lumen	MPO GLA MANBA SMPD1 CTSA	4.24e-04	178	74	5	GO:0005775
GeneOntologyCellularComponent	basolateral plasma membrane	RHCG ABCC4 P2RY1 SLC5A6 SLC13A5 AQP9	9.49e-04	320	74	6	GO:0016323
GeneOntologyCellularComponent	basal plasma membrane	RHCG ABCC4 P2RY1 SLC5A6 SLC13A5 AQP9	1.59e-03	354	74	6	GO:0009925
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	TSPAN15 ABCC4 ABCA4 MOSPD2 ATP8A1 MANBA SEC24A SLC6A17 SLC5A7 SV2C OCA2 DGAT1	2.02e-03	1307	74	12	GO:0030659
GeneOntologyCellularComponent	basal part of cell	RHCG ABCC4 P2RY1 SLC5A6 SLC13A5 AQP9	2.21e-03	378	74	6	GO:0045178
GeneOntologyCellularComponent	vesicle membrane	TSPAN15 ABCC4 ABCA4 MOSPD2 ATP8A1 MANBA SEC24A SLC6A17 SLC5A7 SV2C OCA2 DGAT1	2.27e-03	1325	74	12	GO:0012506
GeneOntologyCellularComponent	specific granule	MOSPD2 ATP8A1 DGAT1 ARMC8	2.51e-03	160	74	4	GO:0042581
GeneOntologyCellularComponent	brush border membrane	SLC6A18 SLC5A6 SLC5A2	3.19e-03	83	74	3	GO:0031526
GeneOntologyCellularComponent	exocytic vesicle membrane	ATP8A1 SLC6A17 SLC5A7 SV2C	3.75e-03	179	74	4	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	ATP8A1 SLC6A17 SLC5A7 SV2C	3.75e-03	179	74	4	GO:0030672
GeneOntologyCellularComponent	transport vesicle membrane	ATP8A1 SEC24A SLC6A17 SLC5A7 SV2C	3.83e-03	293	74	5	GO:0030658
GeneOntologyCellularComponent	azurophil granule lumen	MPO GLA CTSA	4.14e-03	91	74	3	GO:0035578
GeneOntologyCellularComponent	specific granule membrane	MOSPD2 ATP8A1 DGAT1	4.14e-03	91	74	3	GO:0035579
GeneOntologyCellularComponent	synaptic vesicle	ATP8A1 SLC6A17 SLC5A7 SV2C CACFD1	4.23e-03	300	74	5	GO:0008021
GeneOntologyCellularComponent	exocytic vesicle	ATP8A1 SLC6A17 SLC5A7 SV2C CACFD1	5.55e-03	320	74	5	GO:0070382
GeneOntologyCellularComponent	endoplasmic reticulum membrane	LMF1 MOSPD2 PTCHD3 SEC24A STIMATE CH25H OCA2 CACFD1 TMEM50B DGAT1 MYORG	5.59e-03	1293	74	11	GO:0005789
GeneOntologyCellularComponent	P-body	SAMD4B LIN28A SAMD4A	5.69e-03	102	74	3	GO:0000932
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	LMF1 MOSPD2 PTCHD3 SEC24A STIMATE CH25H OCA2 CACFD1 TMEM50B DGAT1 MYORG	5.79e-03	1299	74	11	GO:0098827
GeneOntologyCellularComponent	secretory granule lumen	MPO GLA EPX CTSA ARMC8	5.91e-03	325	74	5	GO:0034774
GeneOntologyCellularComponent	secretory granule membrane	ABCC4 MOSPD2 ATP8A1 MANBA DGAT1	6.22e-03	329	74	5	GO:0030667
GeneOntologyCellularComponent	cytoplasmic vesicle lumen	MPO GLA EPX CTSA ARMC8	6.30e-03	330	74	5	GO:0060205
GeneOntologyCellularComponent	vesicle lumen	MPO GLA EPX CTSA ARMC8	6.46e-03	332	74	5	GO:0031983
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	LMF1 MOSPD2 PTCHD3 SEC24A STIMATE CH25H OCA2 CACFD1 TMEM50B DGAT1 MYORG	6.77e-03	1327	74	11	GO:0042175
Domain	Na/ntran_symport_orphan	SLC6A18 SLC6A17 SLC6A15	5.01e-07	5	70	3	IPR002438
Domain	NA_NEUROTRAN_SYMP_2	SLC6A18 SLC6A16 SLC6A17 SLC6A15	5.32e-07	18	70	4	PS00754
Domain	SNF	SLC6A18 SLC6A16 SLC6A17 SLC6A15	6.72e-07	19	70	4	PF00209
Domain	NA_NEUROTRAN_SYMP_1	SLC6A18 SLC6A16 SLC6A17 SLC6A15	6.72e-07	19	70	4	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A18 SLC6A16 SLC6A17 SLC6A15	6.72e-07	19	70	4	PS50267
Domain	Na/ntran_symport	SLC6A18 SLC6A16 SLC6A17 SLC6A15	6.72e-07	19	70	4	IPR000175
Domain	NA_SOLUT_SYMP_1	SLC5A6 SLC5A7 SLC5A2	8.14e-06	11	70	3	PS00456
Domain	NA_SOLUT_SYMP_2	SLC5A6 SLC5A7 SLC5A2	1.08e-05	12	70	3	PS00457
Domain	SSF	SLC5A6 SLC5A7 SLC5A2	1.08e-05	12	70	3	PF00474
Domain	Na/solute_symporter	SLC5A6 SLC5A7 SLC5A2	1.08e-05	12	70	3	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A6 SLC5A7 SLC5A2	1.08e-05	12	70	3	PS50283
Domain	-	SAMD4B SAMD4A	1.38e-05	2	70	2	1.25.40.170
Domain	PHAT_dom	SAMD4B SAMD4A	1.38e-05	2	70	2	IPR015327
Domain	Ion_trans_dom	CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H	6.84e-05	114	70	5	IPR005821
Domain	Ion_trans	CATSPER1 TRPM3 TRPC6 TRPV4 CACNA1H	6.84e-05	114	70	5	PF00520
Domain	PEROXIDASE_1	MPO EPX	2.06e-04	6	70	2	PS00435
Domain	Na/solute_symporter_CS	SLC5A6 SLC5A2	3.82e-04	8	70	2	IPR018212
Domain	Haem_peroxidase	MPO EPX	6.11e-04	10	70	2	IPR010255
Domain	An_peroxidase	MPO EPX	6.11e-04	10	70	2	PF03098
Domain	PEROXIDASE_3	MPO EPX	6.11e-04	10	70	2	PS50292
Domain	Haem_peroxidase_animal	MPO EPX	6.11e-04	10	70	2	IPR019791
Domain	-	MPO EPX	6.11e-04	10	70	2	1.10.640.10
Domain	TRP_channel	TRPC6 TRPV4	7.45e-04	11	70	2	IPR004729
Domain	Glycoside_hydrolase_SF	GLA MANBA MYORG	1.03e-03	53	70	3	IPR017853
Domain	EamA_dom	SLC35C1 SLC35F6	1.22e-03	14	70	2	IPR000620
Domain	EamA	SLC35C1 SLC35F6	1.22e-03	14	70	2	PF00892
Domain	PA	EDEM3 NAALAD2	2.27e-03	19	70	2	PF02225
Domain	PA_domain	EDEM3 NAALAD2	2.27e-03	19	70	2	IPR003137
Domain	MFS_1	SLC16A2 MFSD9 SV2C	3.02e-03	77	70	3	PF07690
Domain	MFS	SLC16A2 MFSD9 SV2C	3.02e-03	77	70	3	IPR011701
Domain	Sugar_transporter_CS	MFSD9 SV2C	6.39e-03	32	70	2	IPR005829
Domain	MFS	SLC16A2 MFSD9 SV2C	7.77e-03	108	70	3	PS50850
Domain	ABC_transporter_CS	ABCC4 ABCA4	1.08e-02	42	70	2	IPR017871
Domain	-	GLA MYORG	1.08e-02	42	70	2	3.20.20.70
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A18 RHCG ABCC4 LMF1 ABCA4 ATP8A1 TRPM3 SLC16A2 SLC35C1 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 ADCY3 AQP9 SLC5A2	3.07e-10	736	57	18	M27287
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC6A18 RHCG ABCC4 LMF1 ABCA4 ATP8A1 TRPM3 SLC16A2 SLC35C1 SLC5A6 TRPC6 SLC5A7 SLC13A5 TRPV4 SLC6A15 AQP9 SLC5A2	7.94e-10	681	57	17	MM14985
Pathway	WP_NRF2_PATHWAY	SLC6A18 ABCC4 SLC6A16 SLC6A17 SLC5A6 SLC5A7 SLC6A15 SLC5A2	8.97e-08	141	57	8	M39454
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A18 RHCG SLC16A2 SLC35C1 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	4.26e-07	238	57	9	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC6A18 RHCG SLC16A2 SLC35C1 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	6.22e-07	249	57	9	M5988
Pathway	WP_NUCLEAR_RECEPTORS_METAPATHWAY	SLC6A18 ABCC4 SLC6A16 SLC6A17 SLC5A6 SLC5A7 SLC6A15 NR3C1 SLC5A2	4.23e-06	314	57	9	M39428
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A18 RHCG SLC5A7 SLC13A5 SLC6A15	1.34e-05	76	57	5	MM15072
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A18 RHCG SLC5A7 SLC13A5 SLC6A15	2.19e-05	84	57	5	M27334
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	GLA UGCG SMPD1 CTSA	6.07e-05	53	57	4	MM14647
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	GLA UGCG SMPD1 CTSA	8.66e-05	58	57	4	M576
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	MPO MOSPD2 ATP8A1 GLA MANBA EPX CTSA DGAT1 ARMC8	1.16e-04	478	57	9	M27620
Pathway	REACTOME_TRP_CHANNELS	TRPM3 TRPC6 TRPV4	1.91e-04	28	57	3	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPM3 TRPC6 TRPV4	1.91e-04	28	57	3	M27241
Pathway	REACTOME_NEUTROPHIL_DEGRANULATION	MPO MOSPD2 ATP8A1 GLA MANBA EPX CTSA DGAT1 ARMC8	1.92e-04	511	57	9	MM15330
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GLA SMPD1 CTSA	3.43e-04	34	57	3	MM17076
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	GLA UGCG SMPD1 CTSA	5.15e-04	92	57	4	MM15086
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GLA SMPD1 CTSA	5.17e-04	39	57	3	M48042
Pathway	KEGG_SPHINGOLIPID_METABOLISM	GLA UGCG SMPD1	5.17e-04	39	57	3	M15955
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC16A2 SLC35C1 SLC5A6	5.99e-04	41	57	3	MM15075
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	SLC6A18 SLC35C1 SLC5A7 SLC5A2	6.80e-04	99	57	4	M27474
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC16A2 SLC35C1 SLC5A6	6.90e-04	43	57	3	M881
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	GLA UGCG SMPD1 CTSA	9.10e-04	107	57	4	M14857
Pathway	KEGG_LYSOSOME	GLA MANBA SMPD1 CTSA	1.44e-03	121	57	4	M11266
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	EDEM3 MGAT5 SLC35C1 SEC24A CTSA GMPPB	1.45e-03	307	57	6	M894
Pathway	WP_PROXIMAL_TUBULE_TRANSPORT	SLC6A18 ABCC4 SLC5A2	1.57e-03	57	57	3	M39812
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	FSHR ADCY3	1.86e-03	16	57	2	M47650
Pathway	REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS	SLC35C1 CTSA GMPPB	2.19e-03	64	57	3	M892
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EDEM3 ABCC4 MGAT5 MOSPD2 GLA MANBA SLC5A6 IPO13 SLC6A15 SMPD1 CTSA DGAT1 MYORG	1.38e-06	1201	74	13	35696571
Pubmed	Blood-Brain Barrier: From Physiology to Disease and Back.	ABCC4 ATP8A1 SLC16A2 SLC6A17 SLC5A6	3.11e-06	105	74	5	30280653
Pubmed	Uncovering a new role for peroxidase enzymes as drivers of angiogenesis.	MPO EPX	4.47e-06	2	74	2	26386352
Pubmed	Neurotransmitter transporters in the central nervous system.	SLC6A16 SLC6A15	4.47e-06	2	74	2	10471414
Pubmed	Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.	MPO EPX	4.47e-06	2	74	2	28260049
Pubmed	Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family.	SLC6A16 SLC6A15	4.47e-06	2	74	2	11112352
Pubmed	Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.	MPO EPX	4.47e-06	2	74	2	27836774
Pubmed	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	SAMD4B SAMD4A	4.47e-06	2	74	2	16221671
Pubmed	Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells.	IPO13 NR3C1	4.47e-06	2	74	2	16809634
Pubmed	Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.	SLC6A17 SLC6A15	4.47e-06	2	74	2	19147495
Pubmed	P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.	P2RY1 TRPV4	4.47e-06	2	74	2	26475857
Pubmed	MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation.	ABCC4 CATSPER1	4.47e-06	2	74	2	31253671
Pubmed	TRP channels activated by extracellular hypo-osmoticity in epithelia.	TRPM3 TRPV4	4.47e-06	2	74	2	17233610
Pubmed	Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4.	TRPC6 TRPV4	4.47e-06	2	74	2	27874267
Pubmed	TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6.	TRPC6 TRPV4	4.47e-06	2	74	2	38338818
Pubmed	Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types.	GLA UGCG	4.47e-06	2	74	2	29982630
Pubmed	Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.	MPO EPX	4.47e-06	2	74	2	7809065
Pubmed	Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B.	MPO DNMT3B	4.47e-06	2	74	2	24457336
Pubmed	The repertoire of solute carriers of family 6: identification of new human and rodent genes.	SLC6A18 SLC6A17 SLC6A15	1.20e-05	21	74	3	16125675
Pubmed	TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization.	TRPC6 TRPV4	1.34e-05	3	74	2	19439599
Pubmed	The potential for repositioning antithyroid agents as antiasthma drugs.	MPO EPX	1.34e-05	3	74	2	27444178
Pubmed	Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.	MPO EPX	1.34e-05	3	74	2	30565999
Pubmed	Thiocyanate modulates the catalytic activity of mammalian peroxidases.	MPO EPX	1.34e-05	3	74	2	15894800
Pubmed	The evolutionary conservation of the mammalian peroxidase genes.	MPO EPX	1.34e-05	3	74	2	12584448
Pubmed	Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.	CATSPER1 SPATA16	1.34e-05	3	74	2	35248021
Pubmed	The eosinophil peroxidase gene forms a cluster with the genes for myeloperoxidase and lactoperoxidase on human chromosome 17.	MPO EPX	1.34e-05	3	74	2	10828600
Pubmed	TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.	TRPC6 TRPV4	1.34e-05	3	74	2	32931478
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM3 TRPC6 TRPV4	1.81e-05	24	74	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM3 TRPC6 TRPV4	2.06e-05	25	74	3	16382100
Pubmed	An introduction to TRP channels.	TRPM3 TRPC6 TRPV4	2.61e-05	27	74	3	16460286
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	EDEM3 GLA MANBA CTSA MYORG	2.72e-05	164	74	5	32409323
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	NAALAD2 SLC5A6 SLC35F6 MFSD9 CACNA1H CACFD1 ADCY3	3.71e-05	430	74	7	16303743
Pubmed	Hypermethylation of glucocorticoid receptor gene promoter results in glucocorticoid receptor gene low expression in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.	NR3C1 DNMT3B	4.45e-05	5	74	2	25899090
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM3 TRPC6 TRPV4	4.82e-05	33	74	3	19834762
Pubmed	Pilot study of newborn screening for six lysosomal storage diseases using Tandem Mass Spectrometry.	GLA SMPD1	6.66e-05	6	74	2	27238910
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM3 TRPC6 TRPV4	1.15e-04	44	74	3	19322198
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	LETMD1 SLC5A6 STIMATE CH25H IPO13 CACNA1H CTSA DGAT1	1.18e-04	697	74	8	28298427
Pubmed	Establishment and Dysfunction of the Blood-Brain Barrier.	ABCC4 SLC16A2 SLC5A6	1.90e-04	52	74	3	26590417
Pubmed	Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.	GLA MANBA	2.43e-04	11	74	2	19710420
Pubmed	A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.	SAMD4B SAMD4A	2.43e-04	11	74	2	26609159
Pubmed	Melanopsin signalling in mammalian iris and retina.	TRPC6 TRPV4	3.43e-04	13	74	2	22051675
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	MPO RHCG MGAT5 ATP8A1 GLA SMPD1 TMC5 EPX CTSA	4.40e-04	1070	74	9	23533145
Pubmed	Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.	TRPM3 TRPV4	6.68e-04	18	74	2	31911949
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	MGAT5 DNAH10 SLC35C1 SLC6A17	7.81e-04	193	74	4	22589738
Pubmed	Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.	FSHR NR3C1	8.28e-04	20	74	2	20716560
Pubmed	Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.	ATP8A1 P2RY1 STIMATE	9.82e-04	91	74	3	22610502
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC4 ABCA4	1.00e-03	22	74	2	8894702
Pubmed	Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.	SLC5A7 NR3C1	1.20e-03	24	74	2	36109497
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	OCA2 SAMD4A	1.20e-03	24	74	2	24023788
Pubmed	Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.	NR3C1 DGAT1	1.20e-03	24	74	2	27754788
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SLC5A6 UGCG TRPV4 SLC6A15 ADCY3	1.27e-03	377	74	5	38117590
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	P2RY1 ADCY3	1.30e-03	25	74	2	28154160
Pubmed	Congenital Myasthenic Syndromes Overview	SLC5A7 GMPPB	1.40e-03	26	74	2	20301347
Pubmed	A "double adaptor" method for improved shotgun library construction.	MGAT5 ATP8A1 SLC16A2 COX4I1 MFSD9 CACNA1H	1.41e-03	574	74	6	8619474
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	UGCG SMPD1	1.51e-03	27	74	2	23096701
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	ABCA4 TMC5	1.51e-03	27	74	2	18649358
Pubmed	Rex1/Zfp42 as an epigenetic regulator for genomic imprinting.	NR3C1 DNMT3B	1.51e-03	27	74	2	21233130
Pubmed	A genetic approach to Mammalian glycan function.	MGAT5 UGCG	1.87e-03	30	74	2	12676797
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC6A18 SLC6A15	2.00e-03	31	74	2	18195088
Pubmed	Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.	ABCA4 COX18	2.13e-03	32	74	2	21546767
Interaction	ALG11 interactions	TSPAN15 GLA SMPD1 NR3C1 CLEC12B	1.53e-06	60	66	5	int:ALG11
Interaction	SLC35C1 interactions	SLC35C1 TRPC6 ARMC8	5.43e-06	11	66	3	int:SLC35C1
Interaction	TTYH1 interactions	ABCC4 LETMD1 ATP8A1 SLC35F6 MFSD9 CACNA1H ADCY3 DGAT1	5.97e-06	300	66	8	int:TTYH1
Cytoband	17q23.1	MPO EPX	3.03e-04	16	74	2	17q23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2p23	SLC5A6 SLC35F6 ADCY3	1.83e-03	149	74	3	chr2p23
GeneFamily	Solute carriers	SLC6A18 RHCG SLC16A2 SLC6A16 SLC35C1 SLC6A17 SLC5A6 SLC5A7 SLC13A5 SLC6A15 SLC5A2	6.52e-09	395	49	11	752
GeneFamily	Transient receptor potential cation channels	TRPM3 TRPC6 TRPV4	5.84e-05	28	49	3	249
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ABCC4 ATP8A1 SLC16A2 CH25H NR3C1 DNMT3B	4.89e-07	176	74	6	437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC6A17 KLHDC8A SV2C SLC6A15 CACNA1H	1.09e-05	175	74	5	182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ATP8A1 TRPM3 UGCG PPP1R16B AQP9	1.22e-05	179	74	5	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FBXO9 UGCG CH25H MFSD9 DGAT1	1.32e-05	182	74	5	21744c9c792e57d5d41b25986f419b2358c7057b
ToppCell	control-immature_Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MPO EDEM3 MOSPD2 SLC35C1 CH25H	1.88e-05	196	74	5	e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC6A17 CH25H SLC6A15 CACNA1H ADCY3	1.98e-05	198	74	5	f261a37dd07976548b897af86df1d1a0dc069889
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAALAD2 TRPM3 TRPC6 CACNA1H ADCY3	1.98e-05	198	74	5	882710bd6215e299257dd3df234292db9a2823ba
ToppCell	COVID_vent\|World / Disease condition, Lineage, Cell class and subclass	EDEM3 SEC24A CTSA AQP9 IGHV3-64	2.07e-05	200	74	5	1d88e5cc4534073f27a7562e1c4b884bd67f09d9
Drug	gadolinium	CATSPER1 TRPM3 TRPC6 UGCG TRPV4 CACNA1H SMPD1 CTSA	1.96e-07	199	71	8	CID000023982
Drug	chloride	MPO MANBA P2RY1 SLC6A16 COX4I1 SLC5A6 SLC5A7 SLC13A5 SV2C SLC6A15 SMPD1 EPX ADCY3 AQP9 SLC5A2	5.15e-07	1029	71	15	CID000000312
Drug	1-deoxynojirimycin hydrochloride	MPO MGAT5 GLA MANBA UGCG CTSA	7.88e-07	102	71	6	CID000001374
Drug	bosentan	MPO GLA TRPM3 TRPC6 TRPV4 CACNA1H	9.89e-07	106	71	6	CID000104865
Drug	AC1L3RVN	MPO GLA EPX	1.61e-06	8	71	3	CID000094274
Drug	sodium	SLC6A18 TRPM3 SLC16A2 SLC6A16 SLC5A6 TRPC6 SLC5A7 SLC13A5 SLC6A15 CACNA1H NR3C1 ADCY3 SLC5A2	6.15e-06	944	71	13	CID000000923
Drug	2-bromohexadecanal	MPO EPX	9.59e-06	2	71	2	CID015701742
Drug	bromine trichloride	MPO EPX	9.59e-06	2	71	2	CID003014687
Drug	AC1L22VU	MPO EPX	9.59e-06	2	71	2	CID000040008
Drug	MLD987	MPO EPX	9.59e-06	2	71	2	CID006918516
Drug	reduced ascorbic acid	MPO MANBA EPX GMPPB	1.28e-05	46	71	4	CID000000608
Drug	SR140333	MPO PTCHD3 TRPV4 EPX	1.40e-05	47	71	4	CID000108166
Drug	rhamnose	MPO RHCG MGAT5 GLA PTCHD3 SLC35C1 CTSA ADCY3	1.49e-05	356	71	8	CID000000840
Drug	NL-2	MPO OCA2 NR3C1	2.29e-05	18	71	3	CID011846801
Drug	Man5GlcNAc2	MGAT5 GLA MANBA CTSA	2.63e-05	55	71	4	CID003081562
Drug	4-chloro-1,2-benzoquinone	MPO EPX	2.87e-05	3	71	2	CID000093145
Drug	AC1L2HYK	MPO EPX	2.87e-05	3	71	2	CID000021263
Drug	staurosporine; Down 200; 0.01uM; MCF7; HG-U133A	FBXO9 UGCG NR3C1 EPX TMEM50B SAMD4A	3.39e-05	196	71	6	425_DN
Drug	Trifluoperazine dihydrochloride [440-17-5]; Up 200; 8.4uM; PC3; HT_HG-U133A	NAALAD2 LMF1 SLC35F6 TBC1D8B TMEM50B SAMD4A	3.49e-05	197	71	6	6341_UP
Drug	potassium cyanide	MPO PTCHD3 COX4I1 SLC5A7 EPX	3.54e-05	119	71	5	CID000009032
Drug	BAPTA-AM	CATSPER1 P2RY1 TRPC6 SMPD1 ADCY3 AQP9 SLC5A2	3.58e-05	293	71	7	CID000002293
Drug	Flecainide acetate [54143-56-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	LMF1 MANBA SLC16A2 SMPD1 NR3C1 ADCY3	3.59e-05	198	71	6	3418_DN
Drug	4-chloro-1-naphthol	MPO EPX CTSA	4.92e-05	23	71	3	CID000011787
Drug	Westcort	MPO NR3C1	5.73e-05	4	71	2	CID000042395
Drug	AC1L2O1K	MPO EPX	5.73e-05	4	71	2	CID000125126
Drug	4-nitroestradiol	MPO EPX	5.73e-05	4	71	2	CID000233494
Drug	i0830	MPO EPX	5.73e-05	4	71	2	CID000151254
Drug	AC1O3H1D	UGCG SMPD1 OCA2 EPX	5.74e-05	67	71	4	CID006328166
Drug	atofluding	MPO SLC5A7 EPX	6.36e-05	25	71	3	CID000126342
Drug	diiodotyrosine	MPO GLA EPX	6.36e-05	25	71	3	CID000006181
Drug	pemetrexed	ABCC4 GLA SMPD1 EPX	7.61e-05	72	71	4	CID000060843
Drug	Bi-E	ABCA4 GLA SMPD1	8.06e-05	27	71	3	CID006914595
Drug	CI-949	MPO EPX	9.53e-05	5	71	2	CID000159562
Drug	Pummerer's ketone	MPO EPX	9.53e-05	5	71	2	CID000099055
Drug	AC1MOE91	MPO EPX	9.53e-05	5	71	2	CID003342294
Drug	isotrityrosine	MPO EPX	9.53e-05	5	71	2	CID000196044
Drug	AC1Q6QQG	MPO EPX	9.53e-05	5	71	2	CID000124376
Drug	2-chloro-1,4-dimethoxybenzene	MPO EPX	9.53e-05	5	71	2	CID000246724
Drug	4-biphenylboronic acid	MPO EPX	9.53e-05	5	71	2	CID000151253
Drug	t383	MPO EPX	9.53e-05	5	71	2	CID000074847
Drug	gold nanoparticles	MPO SLC5A7 EPX ADCY3 AQP9 TMEM50B	1.11e-04	243	71	6	CID000023985
Drug	Air Pollutants	TSPAN15 ABCC4 LETMD1 MANBA OR4C6 SMPD1 TMC5 TBC1D8B GMPPB TMEM50B MYORG	1.19e-04	917	71	11	ctd:D000393
Drug	Amplex Red reagent	MPO SMPD1 EPX	1.23e-04	31	71	3	CID000167453
Drug	verlukast	MPO ABCC4 EPX	1.35e-04	32	71	3	ctd:C059141
Drug	bromamine	MPO EPX	1.43e-04	6	71	2	CID000123346
Drug	5-hydroxyconiferyl alcohol	MPO EPX	1.43e-04	6	71	2	CID005282095
Drug	PPHP	MPO EPX	1.43e-04	6	71	2	CID006438577
Drug	4-methoxymandelic acid	MPO EPX	1.43e-04	6	71	2	CID000112056
Drug	pulcherosine	MPO EPX	1.43e-04	6	71	2	CID000124402
Drug	indamine	MPO EPX	1.43e-04	6	71	2	CID000010841
Drug	ammonium tartrate	MPO EPX	1.43e-04	6	71	2	CID000018352
Drug	3',4'-dehydrovinblastine	MPO EPX	1.43e-04	6	71	2	CID000151120
Drug	terbumeton	SMPD1 NR3C1	1.43e-04	6	71	2	CID000036584
Drug	sphingadienine	GLA CTSA	1.43e-04	6	71	2	CID006449795
Drug	Pmx-53	MPO EPX	1.43e-04	6	71	2	CID006918468
Drug	sodium azide	MPO COX4I1 SMPD1 EPX	1.45e-04	85	71	4	CID000033557
Drug	epicholesterol	ABCA4 GLA CH25H SLC13A5 SMPD1 NR3C1 CTSA ADCY3 DGAT1	1.56e-04	636	71	9	CID000000304
Drug	3-(3,4-dimethoxyphenyl) acrylate	MPO EPX	1.99e-04	7	71	2	CID000016848
Drug	N-(carboxyheptyl)maleimide	MPO EPX	1.99e-04	7	71	2	CID000092656
Drug	cyclohexanal	PTCHD3 NR3C1	1.99e-04	7	71	2	CID000016275
Drug	benzidinediimine	MPO EPX	1.99e-04	7	71	2	CID000115267
Drug	asarol methyl ether	MPO EPX	1.99e-04	7	71	2	CID000097686
Drug	(2S,3R)-Sphingosine	MGAT5 GLA TRPM3 UGCG TRPV4 SMPD1 CTSA	2.09e-04	389	71	7	CID000001104
Drug	ditercalinium	MPO ABCA4 EPX	2.09e-04	37	71	3	CID000003119
Drug	nojirimycin	GLA MANBA CTSA	2.27e-04	38	71	3	CID000065242
Drug	ng S	GLA MANBA EPX	2.64e-04	40	71	3	CID000440235
Drug	CI-959	MPO EPX	2.65e-04	8	71	2	CID000159289
Drug	PH 163	MPO EPX	2.65e-04	8	71	2	ctd:C104857
Drug	RbBr	MPO EPX	2.65e-04	8	71	2	CID004670918
Drug	oleoylethanolamide	UGCG TRPV4 SMPD1 AQP9	2.72e-04	100	71	4	CID000004383
Drug	Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; PC3; HT_HG-U133A	ATP8A1 SLC6A16 UGCG CACFD1 SAMD4A	2.90e-04	186	71	5	6672_UP
Drug	DESs	MPO SLC5A7 EPX	3.06e-04	42	71	3	CID000011339
Drug	nifedipine	CATSPER1 TRPM3 TRPC6 CH25H TRPV4 CACNA1H SMPD1	3.10e-04	415	71	7	CID000004485
Drug	Verapamil	MPO ABCC4 CACNA1H NR3C1	3.27e-04	105	71	4	ctd:D014700
Drug	2a-e	MGAT5 GLA CTSA	3.28e-04	43	71	3	CID000006942
Drug	Astemizole [68844-77-9]; Down 200; 8.8uM; HL60; HG-U133A	MPO EDEM3 MGAT5 CACFD1 ARMC8	3.36e-04	192	71	5	1365_DN
Drug	Glc-ceramide	GLA UGCG SMPD1 CTSA	3.39e-04	106	71	4	CID005319015
Drug	N-bromosuccinamide	GLA MANBA	3.40e-04	9	71	2	CID009834204
Drug	AC1O5E2B	MPO EPX	3.40e-04	9	71	2	CID002724224
Drug	Reactive Black 5	MPO EPX	3.40e-04	9	71	2	CID005360531
Drug	isothiocyanato thiocyanate	MPO EPX	3.40e-04	9	71	2	CID000521282
Drug	19-noraldosterone	UGCG NR3C1	3.40e-04	9	71	2	CID000127113
Drug	deuterohemin	MPO EPX	3.40e-04	9	71	2	CID003082177
Drug	3,3'-diaminobenzidine	MPO SLC5A7 EPX	3.51e-04	44	71	3	CID000007071
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A	LMF1 MANBA SLC35C1 SMPD1 TMC5	3.52e-04	194	71	5	7214_DN
Drug	oxaprozin; Down 200; 300uM; MCF7; HT_HG-U133A_EA	LMF1 SLC16A2 IPO13 ADCY3 ARMC8	3.52e-04	194	71	5	971_DN
Drug	creatinine	MPO ABCA4 GLA PTCHD3 TRPC6 EPX	3.60e-04	302	71	6	CID000000588
Drug	thryroxine	MPO SLC16A2 SLC5A7 NR3C1 EPX ADCY3	3.60e-04	302	71	6	CID000000853
Drug	Suxibuzone [27470-51-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A	P2RY1 SV2C CACNA1H NR3C1 SLC5A2	3.61e-04	195	71	5	6065_UP
Drug	Raloxifene hydrochloride [82640-04-8]; Up 200; 7.8uM; MCF7; HT_HG-U133A	EDEM3 MFSD9 CACFD1 NR3C1 SAMD4A	3.61e-04	195	71	5	6235_UP
Drug	Oxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A	EDEM3 SLC35C1 KLHDC8A CACNA1H ADCY3	3.61e-04	195	71	5	2278_DN
Drug	Ozagrel hydrochloride [78712-43-3]; Down 200; 15.2uM; MCF7; HT_HG-U133A	FBXO9 SMPD1 CACFD1 NR3C1 SAMD4A	3.61e-04	195	71	5	3503_DN
Drug	Turbuhaler	MPO ABCC4 NR3C1 EPX	3.64e-04	108	71	4	CID000002462
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; PC3; HT_HG-U133A	ATP8A1 SLC35C1 SEC24A CACFD1 SLC5A2	3.69e-04	196	71	5	2047_UP
Drug	Estrone [53-16-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	MGAT5 TRPM3 CACFD1 EPX SAMD4A	3.69e-04	196	71	5	6647_UP
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; PC3; HT_HG-U133A	MPO ATP8A1 TRPM3 KLHDC8A SLC6A15	3.78e-04	197	71	5	6714_UP
Drug	Flavoxate hydrochloride [3717-88-2]; Up 200; 9.4uM; HL60; HT_HG-U133A	SLC16A2 PPP1R16B SMPD1 CACFD1 AQP9	3.87e-04	198	71	5	2373_UP
Drug	Chlorambucil [305-03-3]; Up 200; 13.2uM; MCF7; HT_HG-U133A	MGAT5 P2RY1 SLC5A7 CACNA1H LIN28A	3.87e-04	198	71	5	4345_UP
Drug	Flucytosine [2022-85-7]; Down 200; 31uM; MCF7; HT_HG-U133A	P2RY1 SLC35C1 CACNA1H CACFD1 ARMC8	3.87e-04	198	71	5	6450_DN
Drug	Nabumetone [42924-53-8]; Up 200; 17.6uM; MCF7; HT_HG-U133A	MPO TRPV4 CACNA1H SMPD1 NR3C1	3.87e-04	198	71	5	5428_UP
Disease	cataract (implicated_via_orthology)	TRPM3 IPO13 NR3C1	1.11e-04	38	72	3	DOID:83 (implicated_via_orthology)
Disease	microphthalmia (implicated_via_orthology)	TRPM3 IPO13	3.81e-04	12	72	2	DOID:10629 (implicated_via_orthology)
Disease	Mood Disorders	SLC5A7 NR3C1 ADCY3 DNMT3B	7.72e-04	168	72	4	C0525045
Disease	maximal midexpiratory flow rate	OCA2 SAMD4A	1.08e-03	20	72	2	EFO_0004313
Disease	Drug toxicity	ABCC4 CACNA1H NR3C1	1.15e-03	84	72	3	C0013221
Disease	Adverse reaction to drug	ABCC4 CACNA1H NR3C1	1.15e-03	84	72	3	C0041755
Disease	serum iron measurement	MGAT5 TMC5 DNMT3B	1.23e-03	86	72	3	EFO_0006332
Disease	myeloperoxidase (MPO)-DNA complex measurement	MPO EPX	1.31e-03	22	72	2	EFO_0011039
Disease	lung disease (is_implicated_in)	MPO NR3C1	1.31e-03	22	72	2	DOID:850 (is_implicated_in)
Disease	Kidney Failure	GLA TRPC6	1.31e-03	22	72	2	C0035078
Disease	Myasthenic Syndromes, Congenital	SLC5A7 GMPPB	1.57e-03	24	72	2	C0751882
Disease	interstitial lung disease (is_marker_for)	MPO NR3C1	1.70e-03	25	72	2	DOID:3082 (is_marker_for)
Disease	glucose measurement	EDEM3 P2RY1 EPX DGAT1 SYNGAP1	2.38e-03	380	72	5	EFO_0004468

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVSLAMCLFGRMKWF	AQP9	86	O43315
IQLPMWIFMSFALRN	COX18	176	Q8N8Q8
WNNLDFFIMAMAVLD	CATSPER1	511	Q8NEC5
PFFWMFENVVAMKVG	DNMT3B	691	Q9UBC3
QMMLLDAAVYGLLAW	ABCA4	841	P78363
RMRGDMQLFQTFWFL	SMPD1	561	P17405
LNIAAGVWMIMNAFI	CACFD1	56	Q9UGQ2
LWAIMAAPLFMSNDL	GLA	286	P06280
FRLWAFTGMMAQIPL	DGAT1	426	O75907
EAAMLFSSGVFWMGL	ATP8A1	1041	Q9Y2Q0
FQAAWVGALAMGMIF	SLC16A2	141	P36021
GLMYAIWMNLNSFGL	LINC00301	16	Q8NCQ3
EWIDFETLALLFGMM	OCA2	381	Q04671
FLGNSVAIWMFVFHM	P2RY1	66	P47900
MMEFGLSWVFLVAIF	IGHV3-64	1	A0A075B6Q5
YTIFMKGLQMLWADA	LETMD1	86	Q6P1Q0
FFLVTFGFIWGMMLL	MGAT5	16	Q09328
NMKNLLFSEMWDIFL	MFSD9	276	Q8NBP5
MLNARTWMDALLAFF	EDEM3	341	Q9BZQ6
QLYAMELQGFWMDIG	GMPPB	206	Q9Y5P6
ALMFMQWGQFIDHDL	EPX	221	P11678
MFMQWGQLLDHDLDF	MPO	251	P05164
MFLMAFALGWRSYRQ	NR3C1	601	P04150
QMAITIWMIGFFHAL	OR12D1	141	P0DN82
LALSYALTLMGMFQW	ABCC4	981	O15439
MACNFMGDEWFVDSL	CTSA	401	P10619
LHAAAFWGQMQMAEL	PPP1R16B	266	Q96T49
RDFAQLGSAHFWGMM	SLC35C1	256	Q96A29
VNGIWALMNMAFQAE	ARMC8	486	Q8IUR7
AQLQMFRAQWMFELA	FBXO9	41	Q9UK97
NTWAMLAIFILVMAN	ADCY3	706	O60266
MAVFGFVLFLVLWLM	UGCG	11	Q16739
ELGIMVWQDFMFACA	MANBA	406	O00462
FLRTMDVFDMEQGGW	KLHDC8A	241	Q8IYD2
AASVMVMGWIFAFAA	FSHR	486	P23945
WNRLDFFIVVAGMME	CACNA1H	171	O95180
GAMFFIGFTALVIMW	COX4I1	106	P13073
DWMLLYQGMVVLAAS	DNAH10	1671	Q8IVF4
ASWFAFAFPNMLVML	SLC13A5	251	Q86YT5
FAFPNMLVMLLFAWL	SLC13A5	256	Q86YT5
FQAWSLMILQVLGDM	FAM87A	166	P0C7U9
QCMWLMQALGFLLSA	IPO13	586	O94829
VWELFSLGFFDMMNV	CH25H	176	O95992
GFMAFWKVNLDSISM	PTCHD3	841	Q3KNS1
AWVGGFMHAMIQLLF	OR4C6	146	Q8NH72
KIVIFDMPWLMNAAF	MOSPD2	181	Q8NHP6
FIPALMGEMFWAAAI	SLC5A7	131	Q9GZV3
MGEMFWAAAIFSALG	SLC5A7	136	Q9GZV3
QIWMMLENIFSLLFR	TAS2R40	71	P59535
SPFWSVMFFLMLVNL	SLC6A15	456	Q9H2J7
FWSFIFFLMLLAMGL	SLC6A16	496	Q9GZN6
QWALFFVLGMALMAD	SV2C	151	Q496J9
DGAFLMDAGSVLMLW	SEC24A	981	O95486
FWTLAFGGVFMMLSL	SLC5A6	256	Q9Y289
AARSAMIADYMFWLG	SPATA16	281	Q9BXB7
VWAMLFFGMLFTLGL	SLC6A18	401	Q96N87
LMSQPLLMFSFFWLG	CLEC12B	191	Q2HXU8
LGFMNEFLELEWGSM	SYNGAP1	646	Q96PV0
NALLMMAVAVFLWGF	SLC5A2	656	P31639
MMFRDQVGILAGWFK	SAMD4B	1	Q5PRF9
LWMLFSGAVNDMATN	TBC1D8B	496	Q0IIM8
MALFFWQHGEEAMAK	TRPM3	676	Q9HCF6
WFMDNYTIMAGILLG	TSPAN15	226	O95858
RVWLFIGFMLMFGSL	TMEM50B	96	P56557
MFGSLIASMWILFGA	TMEM50B	106	P56557
NALMFWVVDNFLMRK	STIMATE	206	Q86TL2
MAWTKYQLFLAGLML	SLC35F6	1	Q8N357
QSDLFAMIGTLFLWM	RHCG	216	Q9UBD6
PFWSVMFFLMLINLG	SLC6A17	456	Q9H1V8
AWRASQMMTFFIFLL	TMC5	826	Q6UXY8
YLFELWNMLDFGMLA	TRPC6	521	Q9Y210
WNMLDFGMLAIFAAS	TRPC6	526	Q9Y210
AVMVFALVLGWMNAL	TRPV4	576	Q9HBA0
MMFRDQVGVLAGWFK	SAMD4A	1	Q9UPU9
MAALWGLYMSLVNVG	LMF1	151	Q96S06
WFNVRMGFGFLSMTA	LIN28A	46	Q9H9Z2
WMCLAAALASFLMGF	NAALAD2	11	Q9Y3Q0
AALASFLMGFMVGWF	NAALAD2	16	Q9Y3Q0
RWLEVAAFMPAMQFS	MYORG	576	Q6NSJ0