Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D16 ARHGAP24 RAPGEF6 TIAM1 TBC1D5 FRMD7 DEPDC5 RIMS1 RAPGEF2	8.40e-05	507	72	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D16 ARHGAP24 RAPGEF6 TIAM1 TBC1D5 FRMD7 DEPDC5 RIMS1 RAPGEF2	8.40e-05	507	72	9	GO:0030695
GeneOntologyMolecularFunction	structural constituent of presynaptic active zone	PCLO RIMS1	3.54e-04	8	72	2	GO:0098882
GeneOntologyMolecularFunction	structural constituent of synapse	SHANK2 PCLO RIMS1	4.66e-04	42	72	3	GO:0098918
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	TBC1D16 SLAIN2 INTU PTPN13 ARHGAP24 BRCA1 TBC1D5 FRMD7 PPP1R9A KANK4 MARCHF7 CEP295 RIMS1 RAPGEF2 MAP4K4	1.46e-05	1189	73	15	GO:0044087
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D16 ARHGAP24 RAPGEF6 TIAM1 TBC1D5 RAPGEF2 MAP4K4	2.49e-05	244	73	7	GO:0043547
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection assembly	TBC1D16 INTU ARHGAP24 TBC1D5 FRMD7 PPP1R9A MARCHF7	2.77e-05	248	73	7	GO:0120032
GeneOntologyBiologicalProcess	regulation of cell projection assembly	TBC1D16 INTU ARHGAP24 TBC1D5 FRMD7 PPP1R9A MARCHF7	2.99e-05	251	73	7	GO:0060491
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	TBC1D16 INTU NEO1 ARHGAP24 TIAM1 KIF26A TBC1D5 FRMD7 PPP1R9A MARCHF7 RAPGEF2 MAP4K4	3.85e-05	846	73	12	GO:0120035
GeneOntologyBiologicalProcess	regulation of cell projection organization	TBC1D16 INTU NEO1 ARHGAP24 TIAM1 KIF26A TBC1D5 FRMD7 PPP1R9A MARCHF7 RAPGEF2 MAP4K4	4.67e-05	863	73	12	GO:0031344
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	NEO1 PTPN13 ARHGAP24 BRCA1 FRMD7 PPP1R9A KANK4 MARCHF7 RAPGEF2 PLEKHH2 MAP4K4 KNL1	4.72e-05	864	73	12	GO:0051129
GeneOntologyBiologicalProcess	regulation of organelle organization	TBC1D16 SLAIN2 INTU BRCA1 TBC1D5 FRMD7 PPP1R9A FSHR MAP3K20 KANK4 MARCHF7 CEP295 RIMS1 PLEKHH2 KNL1	5.94e-05	1342	73	15	GO:0033043
GeneOntologyBiologicalProcess	regulation of neuron migration	SCRT1 KIF26A RAPGEF2 MAPK8IP3	6.90e-05	62	73	4	GO:2001222
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	TBC1D16 INTU ARHGAP24 RAPGEF6 TBC1D5 FRMD7 PPP1R9A MARCHF7 RAPGEF2 MAP4K4	1.20e-04	670	73	10	GO:0120031
GeneOntologyBiologicalProcess	neuron migration	NEO1 SCRT1 KIF26A ASTN2 RAPGEF2 MAPK8IP3	1.23e-04	218	73	6	GO:0001764
GeneOntologyBiologicalProcess	microvillus assembly	RAPGEF6 RAPGEF2 MAP4K4	1.31e-04	28	73	3	GO:0030033
GeneOntologyBiologicalProcess	cell projection assembly	TBC1D16 INTU ARHGAP24 RAPGEF6 TBC1D5 FRMD7 PPP1R9A MARCHF7 RAPGEF2 MAP4K4	1.44e-04	685	73	10	GO:0030031
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D16 ARHGAP24 RAPGEF6 TIAM1 TBC1D5 RAPGEF2 MAP4K4	1.82e-04	335	73	7	GO:0043087
GeneOntologyBiologicalProcess	maternal-to-zygotic transition of gene expression	KMT2B BTG4	1.84e-04	6	73	2	GO:0160021
GeneOntologyBiologicalProcess	microvillus organization	RAPGEF6 RAPGEF2 MAP4K4	2.35e-04	34	73	3	GO:0032528
GeneOntologyBiologicalProcess	negative regulation of stress fiber assembly	FRMD7 PPP1R9A KANK4	3.55e-04	39	73	3	GO:0051497
GeneOntologyBiologicalProcess	regulation of organelle assembly	TBC1D16 INTU BRCA1 TBC1D5 MARCHF7 CEP295	4.71e-04	280	73	6	GO:1902115
GeneOntologyBiologicalProcess	negative regulation of intracellular signal transduction	ARHGAP24 SHANK2 BRCA1 MKRN2 MAP3K20 PER1 STYXL2 MARCHF7 DEPDC5 CMYA5	4.72e-04	795	73	10	GO:1902532
GeneOntologyCellularComponent	growth cone	NEO1 SHANK2 TIAM1 PCLO FRMD7 PPP1R9A MAPK8IP3	2.35e-05	245	73	7	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	NEO1 SHANK2 TIAM1 PCLO FRMD7 PPP1R9A MAPK8IP3	2.89e-05	253	73	7	GO:0030427
GeneOntologyCellularComponent	nuclear body	ZC3H14 UBE2O SCRT1 BRCA1 ADAMTS4 KAT6A CMYA5 PLEKHH2 YTHDC1 PHC1 KNL1	2.82e-04	903	73	11	GO:0016604
GeneOntologyCellularComponent	cytoskeleton of presynaptic active zone	PCLO RIMS1	3.32e-04	8	73	2	GO:0048788
GeneOntologyCellularComponent	distal axon	NEO1 SHANK2 TIAM1 PCLO FRMD7 PPP1R9A MAPK8IP3	8.04e-04	435	73	7	GO:0150034
GeneOntologyCellularComponent	presynaptic cytoskeleton	PCLO RIMS1	1.07e-03	14	73	2	GO:0099569
GeneOntologyCellularComponent	cortical cytoskeleton	PCLO PPP1R9A RIMS1 PLEKHH2	1.08e-03	129	73	4	GO:0030863
GeneOntologyCellularComponent	cell body	NEO1 PTPN13 SHANK2 TIAM1 PCLO FRMD7 PPP1R9A ASTN2 RAPGEF2 MAPK8IP3	1.40e-03	929	73	10	GO:0044297
Domain	PDZ	INTU PTPN13 RAPGEF6 SHANK2 TIAM1 PCLO PPP1R9A FRMPD1 RIMS1 RAPGEF2	2.31e-10	151	70	10	PS50106
Domain	PDZ	INTU PTPN13 RAPGEF6 SHANK2 TIAM1 PCLO PPP1R9A FRMPD1 RIMS1 RAPGEF2	2.47e-10	152	70	10	IPR001478
Domain	PDZ	INTU PTPN13 RAPGEF6 SHANK2 TIAM1 PPP1R9A FRMPD1 RIMS1 RAPGEF2	4.16e-09	148	70	9	SM00228
Domain	-	INTU PTPN13 RAPGEF6 SHANK2 TIAM1 PPP1R9A FRMPD1 RIMS1 RAPGEF2	4.68e-09	150	70	9	2.30.42.10
Domain	PDZ	PTPN13 RAPGEF6 SHANK2 TIAM1 PPP1R9A FRMPD1 RIMS1 RAPGEF2	5.50e-08	141	70	8	PF00595
Domain	FERM_M	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	7.78e-07	46	70	5	PF00373
Domain	-	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.07e-06	49	70	5	1.20.80.10
Domain	FERM_central	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.07e-06	49	70	5	IPR019748
Domain	FERM_domain	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.07e-06	49	70	5	IPR000299
Domain	FERM_1	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.19e-06	50	70	5	PS00660
Domain	FERM_2	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.19e-06	50	70	5	PS00661
Domain	FERM_3	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.19e-06	50	70	5	PS50057
Domain	Band_41_domain	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.19e-06	50	70	5	IPR019749
Domain	B41	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.19e-06	50	70	5	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.19e-06	50	70	5	IPR014352
Domain	FERM_N	PTPN13 FRMD7 FRMPD1 FRMD4B	6.82e-06	33	70	4	PF09379
Domain	FERM_N	PTPN13 FRMD7 FRMPD1 FRMD4B	6.82e-06	33	70	4	IPR018979
Domain	ZnF_C3H1	ZC3H14 ZFP36L1 ZC3H4 MKRN2	3.11e-05	48	70	4	SM00356
Domain	Znf_CCCH	ZC3H14 ZFP36L1 ZC3H4 MKRN2	6.59e-05	58	70	4	IPR000571
Domain	ZF_C3H1	ZC3H14 ZFP36L1 ZC3H4 MKRN2	6.59e-05	58	70	4	PS50103
Domain	FERM_C	PTPN13 FRMD7 FRMD4B	1.23e-04	26	70	3	PF09380
Domain	Znf_FCS	L3MBTL2 PHC1	1.37e-04	5	70	2	IPR012313
Domain	FERM_C	PTPN13 FRMD7 FRMD4B	1.38e-04	27	70	3	SM01196
Domain	FERM_PH-like_C	PTPN13 FRMD7 FRMD4B	1.38e-04	27	70	3	IPR018980
Domain	ZF_FCS	L3MBTL2 PHC1	2.06e-04	6	70	2	PS51024
Domain	cNMP	RAPGEF6 PNPLA6 RAPGEF2	2.78e-04	34	70	3	SM00100
Domain	cNMP_binding	RAPGEF6 PNPLA6 RAPGEF2	2.78e-04	34	70	3	PF00027
Domain	cNMP-bd_dom	RAPGEF6 PNPLA6 RAPGEF2	3.03e-04	35	70	3	IPR000595
Domain	CNMP_BINDING_3	RAPGEF6 PNPLA6 RAPGEF2	3.03e-04	35	70	3	PS50042
Domain	SAM	SHANK2 PPP1R9A MAP3K20 PHC1	3.33e-04	88	70	4	SM00454
Domain	cNMP-bd-like	RAPGEF6 PNPLA6 RAPGEF2	3.87e-04	38	70	3	IPR018490
Domain	SAM_DOMAIN	SHANK2 PPP1R9A MAP3K20 PHC1	4.45e-04	95	70	4	PS50105
Domain	-	ZFP36L1 ZC3H4 MKRN2	4.51e-04	40	70	3	4.10.1000.10
Domain	SAM	SHANK2 PPP1R9A MAP3K20 PHC1	4.82e-04	97	70	4	IPR001660
Domain	Ubiquitin-rel_dom	PTPN13 FRMD7 FRMPD1 RAPGEF2 FRMD4B	6.34e-04	184	70	5	IPR029071
Domain	-	SHANK2 PPP1R9A MAP3K20 PHC1	6.74e-04	106	70	4	1.10.150.50
Domain	-	RAPGEF6 PNPLA6 RAPGEF2	7.73e-04	48	70	3	2.60.120.10
Domain	zf-CCCH	ZFP36L1 ZC3H4 MKRN2	8.21e-04	49	70	3	PF00642
Domain	RmlC-like_jellyroll	RAPGEF6 PNPLA6 RAPGEF2	9.23e-04	51	70	3	IPR014710
Domain	SAM/pointed	SHANK2 PPP1R9A MAP3K20 PHC1	9.75e-04	117	70	4	IPR013761
Domain	PH_dom-like	PTPN13 ARHGAP24 TIAM1 FRMD7 FRMPD1 PLEKHH2 FRMD4B	1.06e-03	426	70	7	IPR011993
Domain	-	KMT2B BRCA1 PCLO MKRN2 KAT6A MARCHF7 RIMS1	1.44e-03	449	70	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2B BRCA1 PCLO MKRN2 KAT6A MARCHF7 RIMS1	1.63e-03	459	70	7	IPR013083
Domain	SAM_1	SHANK2 MAP3K20 PHC1	2.12e-03	68	70	3	PF00536
Domain	Znf_FYVE_PHD	KMT2B PCLO KAT6A RIMS1	2.26e-03	147	70	4	IPR011011
Domain	RasGEFN	RAPGEF6 RAPGEF2	2.52e-03	20	70	2	SM00229
Domain	RasGEF_N	RAPGEF6 RAPGEF2	2.78e-03	21	70	2	PF00618
Domain	Ez/rad/moesin-like	FRMD7 FRMD4B	2.78e-03	21	70	2	IPR000798
Domain	Ras-like_Gua-exchang_fac_N	RAPGEF6 RAPGEF2	3.05e-03	22	70	2	IPR000651
Domain	RASGEF_NTER	RAPGEF6 RAPGEF2	3.05e-03	22	70	2	PS50212
Domain	-	PTPN13 ARHGAP24 TIAM1 FRMD7 PLEKHH2 FRMD4B	3.44e-03	391	70	6	2.30.29.30
Domain	FERM_CS	FRMD7 FRMD4B	3.62e-03	24	70	2	IPR019747
Domain	FN3	NEO1 ASTN2 CMYA5 DSCAML1	5.14e-03	185	70	4	SM00060
Domain	RASGEF_CAT	RAPGEF6 RAPGEF2	5.27e-03	29	70	2	PS50009
Domain	RasGEF	RAPGEF6 RAPGEF2	5.63e-03	30	70	2	PF00617
Domain	-	RAPGEF6 RAPGEF2	5.63e-03	30	70	2	1.10.840.10
Domain	Ras_GEF_dom	RAPGEF6 RAPGEF2	5.63e-03	30	70	2	IPR023578
Domain	RASGEF_cat_dom	RAPGEF6 RAPGEF2	5.63e-03	30	70	2	IPR001895
Domain	RasGEF	RAPGEF6 RAPGEF2	5.63e-03	30	70	2	SM00147
Domain	RA	RAPGEF6 RAPGEF2	6.00e-03	31	70	2	SM00314
Domain	FN3	NEO1 ASTN2 CMYA5 DSCAML1	6.63e-03	199	70	4	PS50853
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZBTB46 INTU PTPN13 PNPLA6 SHANK2 MICAL2 TBC1D5 PPP1R9A KAT6A FRMPD1 ANKRD11 ASTN2 RIMS1 RAPGEF2 BRWD3 MAPK8IP3 ITPKB	9.05e-09	1489	73	17	28611215
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PTPN13 RAPGEF6 ACACB TBC1D5 PPP1R9A MAP3K20 CEP295 RAPGEF2 MAP4K4 FAM83B	3.29e-08	446	73	10	24255178
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SLAIN2 PTPN13 RAPGEF6 TIAM1 ZFP36L1 TBC1D5 MAP3K20 ANKRD11 RAPGEF2 MAP4K4 FAM83B ITPKB	2.26e-07	861	73	12	36931259
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SLAIN2 RAPGEF6 SHANK2 L3MBTL2 ZFP36L1 TBC1D5 MKRN2 MAP3K20 PER1 MARCHF7 RAPGEF2 MAP4K4 FRMD4B	2.27e-07	1038	73	13	26673895
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 DMXL2 UBE2O PTPN13 TIAM1 MICAL2 ASTN2 RAPGEF2 CMYA5 MAP4K4 DSCAML1 FRMD4B BRWD3 MAPK8IP3	3.97e-07	1285	73	14	35914814
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GPRASP1 DMXL2 UBE2O ARHGAP24 SHANK2 ZC3H4 TBC1D5 PPP1R9A RIMS1 RAPGEF2 MAP4K4 MAPK8IP3	7.39e-07	963	73	12	28671696
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KMT2B PCLO RAPGEF2 DSCAML1 MAPK8IP3	1.15e-06	87	73	5	12465718
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ADAMTS4 ASTN2 DEPDC5 ANKLE2 MAP4K4	2.52e-06	102	73	5	9734811
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PTPN13 RAPGEF6 ACACB PPP1R9A ANKLE2 MAP4K4 FAM135A FAM83B	2.92e-06	421	73	8	36976175
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLAIN2 INTU PNPLA6 BRCA1 ZC3H4 TAF7L KAT6A PER1 CEP295 RAPGEF2 BRWD3 KNL1	3.40e-06	1116	73	12	31753913
Pubmed	Rap2A links intestinal cell polarity to brush border formation.	RAPGEF6 RAPGEF2 MAP4K4	3.96e-06	15	73	3	22797597
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GPRASP1 DMXL2 NEO1 UBE2O SHANK2 ACACB PCLO PER1 RIMS1 ANKLE2 MAP4K4 MAPK8IP3	4.19e-06	1139	73	12	36417873
Pubmed	An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.	PCLO PER1	4.35e-06	2	73	2	11285225
Pubmed	The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.	RAPGEF6 RAPGEF2	4.35e-06	2	73	2	24858808
Pubmed	A novel protein interacts with a clock-related protein, rPer1.	GPRASP1 PER1	4.35e-06	2	73	2	11597585
Pubmed	Ligand-dependent dynamics and intramolecular signaling in a PDZ domain.	PTPN13 RAPGEF6	4.35e-06	2	73	2	14698303
Pubmed	Energetics of peptide recognition by the second PDZ domain of human protein tyrosine phosphatase 1E.	PTPN13 RAPGEF6	4.35e-06	2	73	2	17240990
Pubmed	Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions.	PTPN13 RAPGEF6	4.35e-06	2	73	2	12095257
Pubmed	Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.	RAPGEF6 RAPGEF2	4.35e-06	2	73	2	32600317
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SLAIN2 ZC3H14 PTPN13 PNPLA6 KMT2B SHANK2 BRCA1 PPP1R9A POLR2H MAP3K20 ANKRD11 YTHDC1 FAM83B	1.28e-05	1497	73	13	31527615
Pubmed	Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors.	BRCA1 FSHR	1.30e-05	3	73	2	25943777
Pubmed	Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.	RAPGEF6 RAPGEF2	1.30e-05	3	73	2	29747665
Pubmed	Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation.	TIAM1 MAPK8IP3	1.30e-05	3	73	2	20018857
Pubmed	Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes.	PPP1R3A KMT2B	1.30e-05	3	73	2	27587435
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SLAIN2 UBE2O KIF26A ZC3H4 DEPDC5 ANKLE2 MAP4K4 FRMD4B	1.54e-05	529	73	8	14621295
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TBC1D16 RAPGEF6 PNPLA6 KMT2B SHANK2 KIF26A KAT6A PER1 ANKRD11 DEPDC5 MAPK8IP3	1.86e-05	1105	73	11	35748872
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	UBE2O PTPN13 ANKLE2 MAP4K4 FAM135A FAM83B	1.97e-05	263	73	6	34702444
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	NEO1 MICAL2 TBC1D5 FRMD7 PPP1R9A MAP4K4 FAM135A FAM83B	2.58e-05	569	73	8	30639242
Pubmed	METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.	BRCA1 YTHDC1	2.60e-05	4	73	2	32615088
Pubmed	Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.	PPP1R3A PPP1R9A	2.60e-05	4	73	2	29786422
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PTPN13 RAPGEF6 KMT2B ACACB L3MBTL2 PHC1 KNL1	2.84e-05	418	73	7	34709266
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 SHANK2 PCLO PPP1R9A RIMS1 RAPGEF2	2.85e-05	281	73	6	28706196
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SLAIN2 NEO1 PTPN13 BRCA1 ACACB ZC3H4 RAPGEF2 FAM135A FAM83B	3.59e-05	777	73	9	35844135
Pubmed	A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.	PPP1R3A PPP1R9A	4.33e-05	5	73	2	15016827
Pubmed	Intrinsic disorder drives N-terminal ubiquitination by Ube2w.	BRCA1 POLR2H	4.33e-05	5	73	2	25436519
Pubmed	The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.	PPP1R3A BRCA1	4.33e-05	5	73	2	17511879
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 NEO1 UBE2O PTPN13 PNPLA6 TIAM1 L3MBTL2 ANKRD11 ANKLE2 MAP4K4 FAM135A FAM83B	5.85e-05	1487	73	12	33957083
Pubmed	BRCA1 ubiquitinates RPB8 in response to DNA damage.	BRCA1 POLR2H	6.48e-05	6	73	2	17283126
Pubmed	A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.	PCLO RIMS1	6.48e-05	6	73	2	19812333
Pubmed	Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.	PCLO RIMS1	6.48e-05	6	73	2	14734538
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 ADAMTS4 PER1 ASTN2 PLEKHH2 YTHDC1 FAM135A	8.01e-05	493	73	7	15368895
Pubmed	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.	L3MBTL2 PCLO PHC1	8.93e-05	41	73	3	22325352
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DMXL2 NEO1 PTPN13 TBC1D5 ANKLE2 FAM135A FAM83B	9.19e-05	504	73	7	34432599
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DMXL2 UBE2O ZFP36L1 KAT6A NKTR PLEKHH2 DSCAML1 PHC1	9.86e-05	689	73	8	36543142
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	BRCA1 KIF26A ZC3H4 PPP1R9A KNL1 FAM83B	1.14e-04	361	73	6	30344098
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	SHANK2 TIAM1 PCLO RIMS1 MAPK8IP3	1.29e-04	231	73	5	16452087
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZC3H14 UBE2O PTPN13 RAPGEF6 ACACB L3MBTL2 ZC3H4 TBC1D5 KNL1	1.46e-04	934	73	9	33916271
Pubmed	Superresolution imaging of chemical synapses in the brain.	PCLO RIMS1	1.55e-04	9	73	2	21144999
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SLAIN2 ZC3H14 UBE2O PTPN13 RAPGEF6 KMT2B MAP4K4	1.56e-04	549	73	7	38280479
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DMXL2 UBE2O PNPLA6 SHANK2 MICAL2 PCLO PPP1R9A RIMS1 RAPGEF2 MAPK8IP3 ITPKB	1.88e-04	1431	73	11	37142655
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DMXL2 UBE2O SHANK2 PPP1R9A RAPGEF2	1.89e-04	251	73	5	27507650
Pubmed	JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.	RAPGEF6 RAPGEF2	1.93e-04	10	73	2	23885123
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RAPGEF6 PNPLA6 KMT2B ZC3H4 RIMS1 YTHDC1 MAP4K4 MAPK8IP3	2.18e-04	774	73	8	15302935
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2B BRCA1 L3MBTL2 PHC1	2.59e-04	146	73	4	23892456
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	PPP1R3A PTPN13 RAPGEF6 PPP1R9A RAPGEF2	2.65e-04	270	73	5	24366813
Pubmed	De novo genic mutations among a Chinese autism spectrum disorder cohort.	RIMS1 YTHDC1	2.83e-04	12	73	2	27824329
Pubmed	Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.	RAPGEF6 RAPGEF2	3.34e-04	13	73	2	27390776
Pubmed	BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription.	BRCA1 POLR2H	3.34e-04	13	73	2	10725406
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KMT2B KAT6A ANKRD11 PHC1	3.41e-04	157	73	4	30186101
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	SHANK2 PCLO	3.89e-04	14	73	2	16452088
Pubmed	A potential role of p75NTR in the regulation of circadian rhythm and incremental growth lines during tooth development.	DSPP PER1	3.89e-04	14	73	2	36213234
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	SLAIN2 ACACB L3MBTL2 TBC1D5 CEP295 ANKLE2 MAP4K4 FAM83B	4.17e-04	853	73	8	28718761
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	PTPN13 RAPGEF6 MICAL2 ANKRD11	4.41e-04	168	73	4	30631154
Pubmed	Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	PHC1 KNL1	5.12e-04	16	73	2	20301772
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	UBE2O KMT2B L3MBTL2 POLR2H PHC1 KNL1	6.13e-04	495	73	6	27705803
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC19 MUC12	6.51e-04	18	73	2	18834073
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	L3MBTL2 ZC3H4 KAT6A ANKRD11 ANKLE2	6.79e-04	332	73	5	37433992
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ZC3H14 PTPN13 ZC3H4 POLR2H ANKRD11 YTHDC1 ANKLE2 FAM135A	6.95e-04	922	73	8	27609421
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	BRCA1 MAP4K4	7.26e-04	19	73	2	14578343
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	KMT2B BRCA1 L3MBTL2 MUC19 KNL1	7.46e-04	339	73	5	30415952
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	PTPN13 PNPLA6 SHANK2 TBC1D5 PPP1R9A MAP4K4 FAM135A	7.84e-04	719	73	7	35337019
Pubmed	BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma.	UBE2O ZFP36L1	8.06e-04	20	73	2	32509391
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DMXL2 SHANK2 PCLO RIMS1 MAPK8IP3	8.28e-04	347	73	5	17114649
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	NEO1 UBE2O L3MBTL2 CEP295 MAP4K4 FRMD4B KNL1	8.77e-04	733	73	7	34672954
Pubmed	Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.	ASTN2 C4orf54	8.89e-04	21	73	2	20195266
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ZC3H14 MKRN2 POLR2H YTHDC1 DSCAML1	9.52e-04	358	73	5	32460013
Pubmed	Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.	BRCA1 PER1	9.77e-04	22	73	2	18095154
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	SLAIN2 ZC3H14 PTPN13 ACACB TBC1D5 MKRN2 ANKLE2 FAM135A	1.22e-03	1007	73	8	34597346
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	UBE2O CEP295 NKTR	1.28e-03	101	73	3	24613305
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	INTU KIF26A PPP1R9A	1.35e-03	103	73	3	10574462
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KMT2B RIMS1 RAPGEF2	1.39e-03	104	73	3	9205841
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SHANK2 ZC3H4 MAPK8IP3	1.39e-03	104	73	3	10470851
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	BRCA1 MKRN2 MARCHF7	1.43e-03	105	73	3	22493164
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	PTPN13 PER1 RAPGEF2 KNL1	1.46e-03	232	73	4	25515538
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	NEO1 PTPN13 MAP4K4	1.47e-03	106	73	3	38891874
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	TBC1D16 TBC1D5	1.47e-03	27	73	2	22354992
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	UBE2O ACACB POLR2H KNL1	1.71e-03	242	73	4	34011540
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	UBE2O KMT2B BRCA1 L3MBTL2 KAT6A PHC1	1.76e-03	608	73	6	36089195
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	NEO1 RAPGEF6	1.94e-03	31	73	2	25838543
Pubmed	The synaptic vesicle cycle.	PCLO RIMS1	1.94e-03	31	73	2	15217342
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PTPN13 RAPGEF6 FRMPD1 MARCHF7 CEP295 ANKLE2 FAM135A BTG4	1.95e-03	1084	73	8	11544199
Cytoband	4q21.3	PTPN13 DSPP	1.36e-04	11	73	2	4q21.3
Cytoband	2q24.2	MAP3K20 MARCHF7	5.64e-04	22	73	2	2q24.2
Cytoband	11q23	DSCAML1 BTG4	1.52e-03	36	73	2	11q23
Cytoband	7q22	MUC12 PCOLCE	1.69e-03	38	73	2	7q22
Cytoband	Xq22.1	GPRASP1 TAF7L	2.16e-03	43	73	2	Xq22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr6q13	RIMS1 FAM135A	5.01e-03	66	73	2	chr6q13
Cytoband	Ensembl 112 genes in cytogenetic band chr4q22	MMRN1 DSPP	6.26e-03	74	73	2	chr4q22
GeneFamily	PDZ domain containing	INTU PTPN13 RAPGEF6 SHANK2 TIAM1 PCLO PPP1R9A FRMPD1 RIMS1 RAPGEF2	2.77e-11	152	55	10	1220
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN13 FRMD7 FRMPD1 PLEKHH2 FRMD4B	4.13e-07	50	55	5	1293
GeneFamily	Fibronectin type III domain containing	NEO1 ASTN2 CMYA5 DSCAML1	1.42e-03	160	55	4	555
GeneFamily	CD molecules\|Mucins	MUC19 MUC12	1.84e-03	21	55	2	648
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R3A BRCA1 PPP1R9A KNL1	2.23e-03	181	55	4	694
GeneFamily	Sterile alpha motif domain containing	SHANK2 PPP1R9A PHC1	2.43e-03	88	55	3	760
GeneFamily	Zinc fingers CCCH-type	ZC3H14 ZC3H4	5.07e-03	35	55	2	73
GeneFamily	Ankyrin repeat domain containing	SHANK2 ANKRD11 KANK4 ANKLE2	6.26e-03	242	55	4	403
Coexpression	GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP	GPRASP1 RAPGEF6 ZFP36L1 TBC1D5 KAT6A PER1 PHC1 ITPKB	8.78e-08	200	73	8	M4440
Coexpression	GSE28408_LY6G_POS_VS_NEG_DC_UP	RAPGEF6 TIAM1 KAT6A PER1 ANKRD11 RAPGEF2	1.87e-05	197	73	6	M9547
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ZC3H14 DMXL2 PTPN13 BRCA1 TIAM1 ZC3H4 MICAL2 KAT6A MARCHF7 RAPGEF2 ANKLE2	2.37e-05	856	73	11	M4500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	UBE2O RAPGEF6 TBC1D5 KAT6A MARCHF7 DEPDC5 RAPGEF2 YTHDC1 FAM135A BRWD3 KNL1	2.94e-06	564	72	11	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5	UBE2O ZC3H4 TBC1D5 KAT6A MARCHF7 DEPDC5 CEP295 RAPGEF2 FAM135A BRWD3 KNL1	8.28e-06	629	72	11	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	UBE2O ZC3H4 MICAL2 TBC1D5 PCLO KAT6A DEPDC5 CEP295 RAPGEF2 FRMD4B	3.11e-05	595	72	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 ARHGAP24 SHANK2 PCLO PPP1R9A ASTN2 CMYA5	3.07e-08	193	73	7	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PCLO PPP1R9A ASTN2 CMYA5	7.73e-07	193	73	6	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 ARHGAP24 SHANK2 PCLO PPP1R9A ASTN2	7.96e-07	194	73	6	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PCLO PPP1R9A ASTN2 DSCAML1	8.21e-07	195	73	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 ARHGAP24 SHANK2 TBC1D5 PPP1R9A RAPGEF2	8.97e-07	198	73	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 KANK4 ASTN2 DEPDC5 DSCAML1	3.21e-06	138	73	5	a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCell	10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3\|Liver / Manually curated celltypes from each tissue	NEO1 ACACB PPP1R9A CMYA5 PLEKHH2	7.22e-06	163	73	5	7f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 ACACB CMYA5 ZNF831 DSCAML1	8.86e-06	170	73	5	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN13 SHANK2 PPP1R9A PLEKHH2 PCOLCE	1.08e-05	177	73	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZIM2 ASTN2 RIMS1 FAM135A FAM83B	1.23e-05	182	73	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A NEO1 ARHGAP24 PLEKHH2 PCOLCE	1.23e-05	182	73	5	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A NEO1 ARHGAP24 PLEKHH2 PCOLCE	1.23e-05	182	73	5	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SHANK2 PCLO ASTN2 DSCAML1 FAM83B	1.23e-05	182	73	5	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TBC1D16 PTPN13 SHANK2 MICAL2 KANK4	1.30e-05	184	73	5	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SHANK2 ACACB KANK4 MAP4K4 DSCAML1	1.33e-05	185	73	5	1d874608aa2062024323512f68889219471b2f00
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SHANK2 PCLO ASTN2 DSCAML1 FAM83B	1.40e-05	187	73	5	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN13 ARHGAP24 SHANK2 MICAL2 KANK4	1.44e-05	188	73	5	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	PTPN13 SHANK2 PPP1R9A RIMS1 FAM83B	1.48e-05	189	73	5	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 ACACB TBC1D5 ASTN2 PLEKHH2	1.48e-05	189	73	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	PTPN13 SHANK2 MICAL2 PCLO PPP1R9A	1.56e-05	191	73	5	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN13 TIAM1 ADAMTS4 PLEKHH2 PCOLCE	1.59e-05	192	73	5	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHANK2 PPP1R9A ASTN2 CMYA5 FAM135A	1.68e-05	194	73	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PCLO PPP1R9A ASTN2	1.68e-05	194	73	5	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN13 SHANK2 MICAL2 PPP1R9A FRMD4B	1.68e-05	194	73	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3A ARHGAP24 NKTR CMYA5 PCOLCE	1.72e-05	195	73	5	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP24 SHANK2 TBC1D5 PPP1R9A RAPGEF2	1.76e-05	196	73	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PCLO PPP1R9A ASTN2	1.76e-05	196	73	5	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	IPF-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	PTPN13 RAPGEF6 TIAM1 ZNF831 FRMD4B	1.76e-05	196	73	5	6e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PCLO PPP1R9A ASTN2	1.76e-05	196	73	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PPP1R9A ASTN2 DSCAML1	1.80e-05	197	73	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN13 SHANK2 MICAL2 PPP1R9A FRMD4B	1.85e-05	198	73	5	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPN13 ZFP36L1 NKTR RIMS1 CMYA5	1.89e-05	199	73	5	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPN13 ZFP36L1 NKTR RIMS1 CMYA5	1.89e-05	199	73	5	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPN13 ZFP36L1 NKTR RIMS1 CMYA5	1.89e-05	199	73	5	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TBC1D16 BRCA1 MUC19 KNL1	6.21e-05	130	73	4	169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCell	IIH-CD8-memory_CD4\|IIH / Condition, Cell_class and T cell subcluster	TBC1D16 NEO1 MUC12 MAPK8IP3	1.26e-04	156	73	4	e312fc4317d966fb2b570d1a4a3aa865f781ea93
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-Langerhans_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZBTB46 TIAM1 MICAL2 MAP4K4	1.29e-04	157	73	4	10341ed8cbee0f636770a82cf580f6453bee8596
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCLO RFX6 RIMS1 DSCAML1	1.35e-04	159	73	4	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSHR MUC19 PLEKHH2 DSCAML1	1.39e-04	160	73	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 KANK4 PLEKHH2 FRMD4B	1.39e-04	160	73	4	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 KANK4 PLEKHH2 FRMD4B	1.39e-04	160	73	4	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSHR MUC19 PLEKHH2 DSCAML1	1.39e-04	160	73	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs\|GI_large-bowel / Manually curated celltypes from each tissue	PTPN13 TIAM1 ASTN2 ITPKB	1.45e-04	162	73	4	9a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	RAPGEF6 KAT6A NKTR ZNF831	1.45e-04	162	73	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZIM2 ASTN2 RIMS1 FAM83B	1.45e-04	162	73	4	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	T_cells-TFH-like_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PTPN13 TIAM1 ZNF831 ITPKB	1.52e-04	164	73	4	b10cf59f4cc37ca6cd0ecf71d7de278cc2bdd8b5
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Tregs\|bone_marrow / Manually curated celltypes from each tissue	GPR15 RAPGEF6 TIAM1 FRMD4B	1.56e-04	165	73	4	1ae1ad4e1fe19b6eefff0f9a03d58a384f169759
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZBTB46 BRCA1 CEP295 DSCAML1	1.56e-04	165	73	4	c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	MMRN1 TIAM1 PPP1R9A TAF7L	1.60e-04	166	73	4	773673a5d0430640439845b264740bfbbdad0cb2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPRASP1 PTPN13 ASTN2 NKTR	1.63e-04	167	73	4	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RFX6 RIMS1 DSCAML1 FAM83B	1.63e-04	167	73	4	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	MMRN1 TIAM1 PPP1R9A TAF7L	1.63e-04	167	73	4	3ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PPP1R3A MAP3K20 CMYA5 C4orf54	1.75e-04	170	73	4	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 PPP1R9A CMYA5 C4orf54	1.75e-04	170	73	4	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10\|TCGA-Brain / Sample_Type by Project: Shred V9	ACACB MAP3K20 CMYA5 ITPKB	1.79e-04	171	73	4	74be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell	Healthy/Control-MAIT\|World / Disease group and Cell class	GPRASP1 NEO1 PER1 ZNF831	1.79e-04	171	73	4	61515114b17816a8f9ef6a57262eb9e977b6ede4
ToppCell	Healthy_donor-MAIT\|World / disease group, cell group and cell class (v2)	GPRASP1 NEO1 PER1 ZNF831	1.83e-04	172	73	4	6524eb2be1c78700ad367e62624a4d7eb48b54f0
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZC3H4 CEP295 RAPGEF2 ZNF831	1.83e-04	172	73	4	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	COPD-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	MMRN1 TIAM1 MICAL2 PPP1R9A	1.87e-04	173	73	4	4a0043b29f8ede5a74bdb38cbf2c70e12b25e130
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPN13 FRMPD1 MAP3K20 PLEKHH2	1.87e-04	173	73	4	d17e50dc400098374af626803dec1241ec566769
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KANK4 CEP295 RIMS1 KNL1	1.91e-04	174	73	4	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZC3H4 CEP295 RAPGEF2 ZNF831	1.95e-04	175	73	4	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MMRN1 DMXL2 ADAMTS4 FRMD4B	2.00e-04	176	73	4	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO RFX6 FAM135A ITPKB	2.08e-04	178	73	4	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NKTR RIMS1 CMYA5 ANKLE2	2.13e-04	179	73	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 FRMPD1 MAP3K20 PLEKHH2	2.13e-04	179	73	4	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	GPRASP1 KIF26A PCLO ASTN2	2.13e-04	179	73	4	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TIAM1 ASTN2 PLEKHH2 PCOLCE	2.17e-04	180	73	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SHANK2 PCLO ASTN2 DSCAML1	2.17e-04	180	73	4	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	PTPN13 MICAL2 PPP1R9A FRMD4B	2.17e-04	180	73	4	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TIAM1 ASTN2 PLEKHH2 PCOLCE	2.17e-04	180	73	4	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	ZC3H14 RAPGEF2 FAM135A PHC1	2.17e-04	180	73	4	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D16 ASTN2 PLEKHH2 DSCAML1	2.22e-04	181	73	4	6a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 FRMPD1 MAP3K20 PLEKHH2	2.22e-04	181	73	4	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN13 SHANK2 PPP1R9A FAM83B	2.22e-04	181	73	4	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	ZBTB46 PTPN13 ADAMTS4 DSCAML1	2.27e-04	182	73	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	PCLO RFX6 RIMS1 DSCAML1	2.27e-04	182	73	4	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SHANK2 TIAM1 ASTN2 FAM83B	2.27e-04	182	73	4	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPRASP1 KIF26A PLEKHH2 PHC1	2.32e-04	183	73	4	5377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D16 ASTN2 PLEKHH2 DSCAML1	2.32e-04	183	73	4	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	PTPN13 SHANK2 MICAL2 PPP1R9A	2.36e-04	184	73	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ASTN2 RIMS1 FAM83B	2.36e-04	184	73	4	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPRASP1 ZBTB46 TIAM1 NKTR	2.36e-04	184	73	4	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	MMRN1 TIAM1 MICAL2 PPP1R9A	2.41e-04	185	73	4	520795866d44def5be3910ce8e728045c716a24d
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	PTPN13 SHANK2 PPP1R9A RIMS1	2.41e-04	185	73	4	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIF26A DSPP KANK4 FRMD4B	2.41e-04	185	73	4	538db481c82b02e5d3b8e03b166f754cc936901e
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZFP36L1 MAP3K20 KANK4 RIMS1	2.46e-04	186	73	4	7def03dd856b765bd3f493288641981c4f7fd26e
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS4 KANK4 BTG4 FRMD4B	2.46e-04	186	73	4	d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZFP36L1 PCLO MUC19 RFX6	2.46e-04	186	73	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCLO RFX6 RIMS1 DSCAML1	2.46e-04	186	73	4	b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 MUC12 FAM135A FAM83B	2.51e-04	187	73	4	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PPP1R3A SHANK2 MICAL2 PPP1R9A	2.51e-04	187	73	4	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 MUC12 FAM135A FAM83B	2.51e-04	187	73	4	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ASTN2 MUC12 FAM135A FAM83B	2.51e-04	187	73	4	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEO1 PTPN13 PER1 ZNF831	2.51e-04	187	73	4	f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PTPN13 PLEKHH2 FRMD4B PCOLCE	2.51e-04	187	73	4	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 ASTN2 DSCAML1 MAPK8IP3	2.51e-04	187	73	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SHANK2 ACACB TBC1D5 DSCAML1	2.51e-04	187	73	4	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NEO1 ZFP36L1 MAP3K20 PCOLCE	2.57e-04	188	73	4	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPN13 SHANK2 MICAL2 PPP1R9A	2.57e-04	188	73	4	c9cdee6f8d42ee69f5fb335f25084603c511bd29
Drug	H-7 dihydrochloride; Up 200; 100uM; PC3; HT_HG-U133A	NEO1 GPR15 SHANK2 ZFP36L1 MICAL2 ASTN2 MAPK8IP3	3.19e-06	199	72	7	5968_UP
Disease	Parkinson disease	MMRN1 TBC1D5 MUC19 RIMS1 MUC12 MAP4K4 ITPKB	1.02e-05	321	69	7	MONDO_0005180
Disease	Autosomal Recessive Primary Microcephaly	ANKLE2 PHC1 KNL1	1.83e-05	22	69	3	C3711387
Disease	eosinophil count	PPP1R3A RAPGEF6 BRCA1 ADAMTS4 ZFP36L1 TBC1D5 MKRN2 ANKRD11 RFX6 ANKLE2 MAP4K4 PHC1 ITPKB	3.56e-05	1488	69	13	EFO_0004842
Disease	Alzheimer disease, polygenic risk score	ARHGAP24 ADAMTS4 MAP3K20 MUC19 RFX6 RIMS1 RAPGEF2 ITPKB	6.65e-05	586	69	8	EFO_0030082, MONDO_0004975
Disease	parenchymal hematoma, response to recombinant tissue-plasminogen activator	ZBTB46 DSCAML1	8.03e-05	6	69	2	EFO_0020101, EFO_0600080
Disease	colonic neoplasm	MAP3K20 ASTN2 ITPKB	1.22e-04	41	69	3	EFO_0004288
Disease	chronotype measurement	ZC3H14 ARHGAP24 TBC1D5 FSHR MAP3K20 PER1 RIMS1 FAM83B ITPKB	2.08e-04	882	69	9	EFO_0008328
Disease	asthma	ZBTB46 DMXL2 RAPGEF6 ADAMTS4 ZFP36L1 ANKRD11 MAP4K4 ITPKB	3.61e-04	751	69	8	MONDO_0004979
Disease	age at menarche	TBC1D16 ZBTB46 BRCA1 ZC3H4 TBC1D5 DSCAML1 FAM83B	4.74e-04	594	69	7	EFO_0004703
Disease	creatinine measurement	PPP1R3A ZBTB46 INTU FRMD7 ANKRD11 ASTN2 PLEKHH2 BRWD3 FAM83B	5.02e-04	995	69	9	EFO_0004518
Disease	Autosomal recessive primary microcephaly	PHC1 KNL1	5.55e-04	15	69	2	cv:C3711387
Disease	inflammatory bowel disease	SLAIN2 ZFP36L1 MUC19 RFX6 ZNF831 MAP4K4	6.41e-04	449	69	6	EFO_0003767
Disease	wellbeing measurement	SLAIN2 RAPGEF6 L3MBTL2 PCLO FSHR MUC19 FAM83B	1.16e-03	692	69	7	EFO_0007869
Disease	Primary microcephaly	PHC1 KNL1	1.21e-03	22	69	2	C0431350
Disease	Neurodevelopmental Disorders	ZC3H4 ANKRD11 RIMS1	1.37e-03	93	69	3	C1535926
Disease	Adenoid Cystic Carcinoma	BRCA1 KAT6A ZIM2	1.68e-03	100	69	3	C0010606
Disease	response to perphenazine	ASTN2 C4orf54	1.69e-03	26	69	2	GO_0097334
Disease	eosinophil percentage of leukocytes	PPP1R3A KMT2B ADAMTS4 TBC1D5 RFX6 PHC1 ITPKB	1.78e-03	746	69	7	EFO_0007991
Disease	Hypermetropia	ANKRD11 DSCAML1 ITPKB	1.83e-03	103	69	3	HP_0000540
Disease	executive function measurement	DMXL2 TBC1D5 RIMS1 RAPGEF2 ZNF831	1.89e-03	376	69	5	EFO_0009332
Disease	unipolar depression	TBC1D16 SHANK2 L3MBTL2 MICAL2 TBC1D5 PCLO PER1 ASTN2 ITPKB	1.93e-03	1206	69	9	EFO_0003761

Protein segments in the cluster

Peptide	Gene	Start	Entry
SDTDTYRAGATASKE	ANKLE2	181	Q86XL3
ESDYSSEGSSVESLK	ANKRD11	576	Q6UB99
LKNYDFGSSTETSDS	GPR15	321	P49685
SDSDSESTSRTDQDY	BRWD3	1621	Q6RI45
SSRGDASYNSDESKD	DSPP	486	Q9NZW4
SSDDVDYRGSTTTLY	DMXL2	2711	Q8TDJ6
SSFVVSEGSYLDISD	ASTN2	476	O75129
IRSGLDDVEASSSYS	MKRN2	151	Q9H000
VSDLSVTADGFSASY	PCOLCE	256	Q15113
DSGRKQTSSFYTDTS	RFX6	846	Q8HWS3
DDYSSDEDSVAGSSR	ACACB	171	O00763
SSSLGYTSTRDVLEN	DEPDC5	546	O75140
SQDETDLSTYGDSLS	PNPLA6	1161	Q8IY17
VTDYSSSSEESGTTD	MAP4K4	761	O95819
VYGDDSSDRAASSFI	MAPK8IP3	1206	Q9UPT6
GSESSSYLEESSEAE	L3MBTL2	41	Q969R5
ETYLSRGDSSSSQRT	MMRN1	181	Q13201
TAERYVASESSDSES	FRMD7	641	Q6ZUT3
DSLSVASSSREGYVS	FAM83B	421	Q5T0W9
TYASSRFSDSGVESE	FAM135A	761	Q9P2D6
SYTTSSASDDDRQRT	PER1	656	O15534
YSVDSEGSSSTAGET	PCLO	4956	Q9Y6V0
DFTTRYSSVASGALE	MUC19	1421	Q7Z5P9
ADGTSLDFSTYRSSQ	KNL1	1856	Q8NG31
GSSGYESLRRDSEAT	KIF26A	1656	Q9ULI4
GDSSEEESSPTSRYI	KMT2B	2021	Q9UMN6
GVSLSSVASESDYAI	PLEKHH2	656	Q8IVE3
QSLYTSGEKESDSSA	PPP1R3A	1036	Q16821
SRESTDGSINSYSSE	RIMS1	1486	Q86UR5
FEDRVSDSGSYSSAS	INTU	31	Q9ULD6
SSQSASSSSEEGYLE	KAT6A	371	Q92794
SRATSSSDNSETFVG	ARHGAP24	621	Q8N264
TSVYIELGSDSSEDT	BRCA1	176	P38398
GITTSSDTADFRDLY	FAM189B	496	P81408
SSTEILDDGSSYTSQ	FRMD4B	721	Q9Y2L6
LDDGSSYTSQSSTEY	FRMD4B	726	Q9Y2L6
AVSLRYSGATAASET	ADAMTS4	756	O75173
EVDEGFYSRAASSTS	FAM126A	346	Q9BYI3
DSYSASLSQDTDKGR	DSCAML1	1781	Q8TD84
ASYLSDSSESTASRQ	FRMPD1	716	Q5SYB0
DTSSGNTETLSSKSY	CMYA5	1966	Q8N3K9
SGNTDTSSERGRYSD	MAP3K20	661	Q9NYL2
DSSFRLDSEYQSTSA	MARCHF7	41	Q9H992
GYETTSSEETSGEDS	KANK4	671	Q5T7N3
RSSLAEDNESSYSRG	FSHR	311	P23945
ELVDYSSGASSAVSE	C4orf54	601	D6RIA3
SAYTDDGSETSEGSK	C4orf54	781	D6RIA3
SIGNLSSVYSSSDEA	CEP295	2231	Q9C0D2
VTSEDSSSDTESDYG	MICAL2	1166	O94851
SYSDSSGSGEDDLVT	PTPN13	1651	Q12923
YIASSSGSEDESVKT	GPRASP1	246	Q5JY77
DRGSETTYESSADIA	TAF7L	36	Q5H9L4
ASDSGSSSLSDIYQA	RAPGEF6	196	Q8TEU7
SSADLESAYGRARSD	SCRT1	16	Q9BWW7
QEYAATTSRRSSGSS	SLAIN2	291	Q9P270
SESDQSTYSKYSDRS	NKTR	671	P30414
TGFSSSYEDSEEDIS	ITPKB	606	P27987
TSSSYLASSQEEDSG	NEO1	1331	Q92859
FSDYSVGSESDSSKE	SHANK2	16	Q9UPX8
SYAVSRASSDVSSGT	BTG4	131	Q9NY30
TSDSGSSSLSDIYQA	RAPGEF2	51	Q9Y4G8
QDSLSDQEGYLSSSS	ZFP36L1	296	Q07352
SDTAADTYGFSLSSV	TIAM1	851	Q13009
DEDTDSAIGSFRYSS	STYXL2	886	Q5VZP5
FSRSTYNETSSSREE	STYXL2	1021	Q5VZP5
SAEGVSRDSSFDSDS	TBC1D16	216	Q8TBP0
ESDYDSVEGSTSGAS	UBE2O	716	Q9C0C9
SSRGSDNSSYDEALS	PHC1	881	P78364
GDETSTEAATRLSAY	POLR2H	101	P52434
GNDYDTRSEASDSGS	YTHDC1	261	Q96MU7
TRSEASDSGSESVSF	YTHDC1	266	Q96MU7
YSSDEDEGGSSVTSI	ZC3H4	806	Q9UPT8
RSYGSDEFERSSNLS	ZIM2	281	Q9NZV7
RTSSTLDSEGTFNSY	TBC1D5	41	Q92609
STDSGYLSRSDSAEQ	ZNF831	341	Q5JPB2
EEDDDYGSRTGSISS	ZC3H14	316	Q6PJT7
ASSSDSRGERAELYA	ZBTB46	321	Q86UZ6
ARSTTSGLVEESTAY	MUC12	1901	Q9UKN1
TRLYDSVSSTDGEDS	PPP1R9A	901	Q9ULJ8