Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX16 EIF4A3 DDX42 ATP8B2 KIF3A ATP6V1H EIF4A1 ABCC12 ATP2B2 ATP2B3 SNRNP200 ATP2B4

1.21e-064419512GO:0016887
GeneOntologyMolecularFunctionP-type calcium transporter activity

ATP2B2 ATP2B3 ATP2B4

1.67e-0511953GO:0005388
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

DHX16 RALA SEPTIN5 EIF4A3 DDX42 ATP8B2 KIF3A ATP6V1H EIF4A1 ABCC12 ATP2B2 ATP2B3 SNRNP200 ATP2B4

1.73e-057759514GO:0017111
GeneOntologyMolecularFunctionphorbol ester receptor activity

UNC13B UNC13C

2.24e-052952GO:0001565
GeneOntologyMolecularFunctionnon-kinase phorbol ester receptor activity

UNC13B UNC13C

2.24e-052952GO:0001566
GeneOntologyMolecularFunctionATP-dependent activity

DHX16 EIF4A3 DDX42 ATP8B2 KIF3A ATP6V1H EIF4A1 ABCC12 ATP2B2 ATP2B3 SNRNP200 ATP2B4

3.42e-056149512GO:0140657
GeneOntologyMolecularFunctionRNA helicase activity

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

3.52e-0578955GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

3.98e-0580955GO:0008186
GeneOntologyMolecularFunctionpyrophosphatase activity

DHX16 RALA SEPTIN5 EIF4A3 DDX42 ATP8B2 KIF3A ATP6V1H EIF4A1 ABCC12 ATP2B2 ATP2B3 SNRNP200 ATP2B4

4.15e-058399514GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

DHX16 RALA SEPTIN5 EIF4A3 DDX42 ATP8B2 KIF3A ATP6V1H EIF4A1 ABCC12 ATP2B2 ATP2B3 SNRNP200 ATP2B4

4.20e-058409514GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

DHX16 RALA SEPTIN5 EIF4A3 DDX42 ATP8B2 KIF3A ATP6V1H EIF4A1 ABCC12 ATP2B2 ATP2B3 SNRNP200 ATP2B4

4.20e-058409514GO:0016818
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP6V1H ABCC12 ATP2B2 ATP2B3 ATP2B4

1.73e-04109955GO:0042626
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

NDUFA9 ATP6V1H ABCC12 ATP2B2 ATP2B3 ATP2B4

2.08e-04178956GO:0015399
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP6V1H ATP2B2 ATP2B3 ATP2B4

2.17e-0462954GO:0019829
GeneOntologyMolecularFunctionglucokinase activity

HK1 HK2

2.22e-045952GO:0004340
GeneOntologyMolecularFunctionhexokinase activity

HK1 HK2

2.22e-045952GO:0004396
GeneOntologyMolecularFunctionfructokinase activity

HK1 HK2

2.22e-045952GO:0008865
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP2B2 ATP2B3 ATP2B4

6.65e-0436953GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP2B2 ATP2B3 ATP2B4

6.65e-0436953GO:0015662
GeneOntologyMolecularFunctionprotein kinase activator activity

MOB3A STK3 MOB3B MARK2 NRG3

7.31e-04149955GO:0030295
GeneOntologyMolecularFunctioncalmodulin binding

UNC13B ADCY1 UNC13C ATP2B2 ATP2B3 ATP2B4

8.10e-04230956GO:0005516
GeneOntologyMolecularFunctionhelicase activity

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

9.51e-04158955GO:0004386
GeneOntologyMolecularFunctionkinase activator activity

MOB3A STK3 MOB3B MARK2 NRG3

9.78e-04159955GO:0019209
GeneOntologyMolecularFunctionkinase activity

HK1 HK2 KALRN MARK1 KSR2 MAP3K1 STK3 SEPHS1 NEK5 N4BP2 MARK2

1.00e-037649511GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

HK1 TENT4B HK2 KALRN MARK1 KSR2 MAP3K1 STK3 SEPHS1 NEK5 N4BP2 MARK2

1.62e-039389512GO:0016772
GeneOntologyMolecularFunctionprotein serine kinase activity

KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 MARK2

1.74e-03363957GO:0106310
GeneOntologyMolecularFunctiontranslation initiation factor activity

EIF4A1 EIF2S2 EIF3B

1.84e-0351953GO:0003743
GeneOntologyMolecularFunctionD-glucose binding

HK1 HK2

1.96e-0314952GO:0005536
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

HK1 HK2 KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 N4BP2 MARK2

2.00e-037099510GO:0016773
GeneOntologyMolecularFunctioncytoskeletal protein binding

RALA SPIRE2 NCALD MARK1 IFT81 TOGARAM2 LRRC10 SHTN1 MAP3K1 KIF3A HPCA AP1AR MARK2

2.07e-0310999513GO:0008092
GeneOntologyMolecularFunctionkinesin binding

SHTN1 KIF3A AP1AR

2.29e-0355953GO:0019894
GeneOntologyMolecularFunctiondiacylglycerol binding

UNC13B UNC13C

2.57e-0316952GO:0019992
GeneOntologyMolecularFunctionmitogen-activated protein kinase kinase binding

KSR2 MAP3K1

3.63e-0319952GO:0031434
GeneOntologyMolecularFunctioncarbohydrate kinase activity

HK1 HK2

4.43e-0321952GO:0019200
GeneOntologyMolecularFunctiontau-protein kinase activity

MARK1 MARK2

4.86e-0322952GO:0050321
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 MARK2

5.41e-03446957GO:0004674
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13B UNC13C

5.77e-0324952GO:0017075
GeneOntologyCellularComponentglutamatergic synapse

UNC13B KALRN MARK1 EIF4A3 SRCIN1 ADCY1 KIF3A HPCA RABEP1 PLEKHA5 MARK2 NRG3 ATP2B2 ATP2B3 ATP2B4

4.56e-068179615GO:0098978
DomainATP_Ca_trans_C

ATP2B2 ATP2B3 ATP2B4

4.92e-074943IPR022141
DomainATP_Ca_trans_C

ATP2B2 ATP2B3 ATP2B4

4.92e-074943PF12424
DomainP-type_ATPase_IIB

ATP2B2 ATP2B3 ATP2B4

4.92e-074943IPR006408
DomainDEAD/DEAH_box_helicase_dom

DHX16 EIF4A3 DDX42 CMSS1 EIF4A1 SNRNP200

1.79e-0673946IPR011545
DomainDEAD

DHX16 EIF4A3 DDX42 CMSS1 EIF4A1 SNRNP200

1.79e-0673946PF00270
DomainATPase_P-typ_cyto_domN

ATP8B2 ATP2B2 ATP2B3 ATP2B4

2.80e-0535944IPR023299
DomainP_typ_ATPase

ATP8B2 ATP2B2 ATP2B3 ATP2B4

3.13e-0536944IPR001757
DomainATPase_P-typ_P_site

ATP8B2 ATP2B2 ATP2B3 ATP2B4

3.13e-0536944IPR018303
DomainATPASE_E1_E2

ATP8B2 ATP2B2 ATP2B3 ATP2B4

3.13e-0536944PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B2 ATP2B2 ATP2B3 ATP2B4

3.50e-0537944IPR008250
DomainE1-E2_ATPase

ATP8B2 ATP2B2 ATP2B3 ATP2B4

3.50e-0537944PF00122
Domain-

ATP2B2 ATP2B3 ATP2B4

6.59e-05169431.20.1110.10
DomainATPase_P-typ_TM_dom

ATP2B2 ATP2B3 ATP2B4

6.59e-0516943IPR023298
DomainUnc-13

UNC13B UNC13C

7.49e-053942IPR027080
DomainPRKG1_interact

PPP1R12A PPP1R12B

7.49e-053942IPR031775
DomainPRKG1_interact

PPP1R12A PPP1R12B

7.49e-053942PF15898
DomainMYPT1/MYPT2_chordates

PPP1R12A PPP1R12B

7.49e-053942IPR017401
DomainATPase_P-typ_cation-transptr_C

ATP2B2 ATP2B3 ATP2B4

7.98e-0517943IPR006068
DomainCation_ATPase_C

ATP2B2 ATP2B3 ATP2B4

7.98e-0517943PF00689
DomainCation_ATPase_N

ATP2B2 ATP2B3 ATP2B4

9.54e-0518943PF00690
DomainCation_ATPase_N

ATP2B2 ATP2B3 ATP2B4

9.54e-0518943SM00831
DomainATPase_P-typ_cation-transptr_N

ATP2B2 ATP2B3 ATP2B4

1.13e-0419943IPR004014
DomainMARK/par1

MARK1 MARK2

1.49e-044942IPR033624
DomainHelicase_C

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.06e-04107945PF00271
DomainHELICc

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.06e-04107945SM00490
DomainHelicase_C

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.15e-04108945IPR001650
DomainHELICASE_CTER

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.24e-04109945PS51194
DomainHELICASE_ATP_BIND_1

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.24e-04109945PS51192
DomainDEXDc

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.24e-04109945SM00487
DomainHelicase_ATP-bd

DHX16 EIF4A3 DDX42 EIF4A1 SNRNP200

2.34e-04110945IPR014001
DomainMunc13_dom-2

UNC13B UNC13C

2.48e-045942IPR014772
DomainMembr_traf_MHD

UNC13B UNC13C

2.48e-045942PF10540
DomainKA1_dom

MARK1 MARK2

2.48e-045942IPR001772
DomainHexokinase_C

HK1 HK2

2.48e-045942IPR022673
DomainHexokinase_N

HK1 HK2

2.48e-045942IPR022672
DomainHexokinase_1

HK1 HK2

2.48e-045942PF00349
DomainHexokinase_2

HK1 HK2

2.48e-045942PF03727
DomainMHD2

UNC13B UNC13C

2.48e-045942PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13C

2.48e-045942IPR019558
DomainKA1

MARK1 MARK2

2.48e-045942PF02149
DomainKA1

MARK1 MARK2

2.48e-045942PS50032
Domain-

MARK1 MARK2

2.48e-0459423.30.310.80
DomainHEXOKINASE_2

HK1 HK2

2.48e-045942PS51748
DomainHexokinase_BS

HK1 HK2

2.48e-045942IPR019807
DomainDUF1041

UNC13B UNC13C

2.48e-045942SM01145
DomainHEXOKINASE_1

HK1 HK2

2.48e-045942PS00378
DomainARM-type_fold

TOGARAM2 HEATR1 CLHC1 MAP3K1 PPP4R3A ATP6V1H NCAPG RRP12

3.11e-04339948IPR016024
DomainHexokinase

HK1 HK2

3.71e-046942IPR001312
DomainDEAD_ATP_HELICASE

EIF4A3 DDX42 EIF4A1

5.01e-0431943PS00039
DomainDUF1041

UNC13B UNC13C

5.18e-047942PF06292
DomainMunc13_1

UNC13B UNC13C

5.18e-047942IPR014770
DomainCAPS_dom

UNC13B UNC13C

5.18e-047942IPR010439
DomainMHD1

UNC13B UNC13C

5.18e-047942PS51258
DomainKA1/Ssp2_C

MARK1 MARK2

5.18e-047942IPR028375
DomainMob1_phocein

MOB3A MOB3B

5.18e-047942PF03637
DomainMOB_kinase_act_fam

MOB3A MOB3B

5.18e-047942IPR005301
Domain-

MOB3A MOB3B

5.18e-0479421.20.140.30
DomainMob1_phocein

MOB3A MOB3B

5.18e-047942SM01388
DomainRNA-helicase_DEAD-box_CS

EIF4A3 DDX42 EIF4A1

6.04e-0433943IPR000629
DomainHAD-like_dom

ATP8B2 ATP2B2 ATP2B3 ATP2B4

6.77e-0479944IPR023214
DomainQ_MOTIF

EIF4A3 DDX42 EIF4A1

8.47e-0437943PS51195
DomainRNA_helicase_DEAD_Q_motif

EIF4A3 DDX42 EIF4A1

8.47e-0437943IPR014014
DomainHydrolase_3

ATP2B2 ATP2B3

1.10e-0310942PF08282
DomainP-loop_NTPase

DHX16 RALA SEPTIN5 EIF4A3 DDX42 CMSS1 KIF3A N4BP2 EIF4A1 ABCC12 SNRNP200 DYNC1LI2

1.11e-038489412IPR027417
Domain-

DHX16 RALA SEPTIN5 EIF4A3 DDX42 CMSS1 N4BP2 EIF4A1 ABCC12 SNRNP200 DYNC1LI2

1.30e-0374694113.40.50.300
DomainRecoverin

NCALD HPCA

1.89e-0313942IPR028846
DomainSer/Thr_kinase_AS

KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 MARK2

2.17e-03357947IPR008271
DomainFerritin-like_SF

MOB3A MOB3B

2.19e-0314942IPR009078
DomainS_TKc

KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 MARK2

2.24e-03359947SM00220
DomainPROTEIN_KINASE_ST

KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 MARK2

2.34e-03362947PS00108
DomainHMG_box

SOX11 KMT2D BBX

2.41e-0353943PF00505
DomainARM-like

TOGARAM2 HEATR1 PPP4R3A ATP6V1H NCAPG RRP12

2.43e-03270946IPR011989
DomainHMG

SOX11 KMT2D BBX

2.54e-0354943SM00398
Domain-

SOX11 KMT2D BBX

2.68e-03559431.10.30.10
DomainC1_1

UNC13B KSR2 UNC13C

2.97e-0357943PF00130
DomainPkinase

KALRN MARK1 KSR2 MAP3K1 STK3 NEK5 MARK2

3.11e-03381947PF00069
DomainZF_DAG_PE_1

UNC13B KSR2 UNC13C

4.12e-0364943PS00479
DomainZF_DAG_PE_2

UNC13B KSR2 UNC13C

4.12e-0364943PS50081
DomainC1

UNC13B KSR2 UNC13C

4.30e-0365943SM00109
DomainHMG_box_dom

SOX11 KMT2D BBX

4.30e-0365943IPR009071
DomainPE/DAG-bd

UNC13B KSR2 UNC13C

4.49e-0366943IPR002219
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

ATP2B2 ATP2B3 ATP2B4

2.95e-0512743M27326
PathwayREACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS

ATP2B2 ATP2B3 ATP2B4

4.85e-0514743MM15052
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RALA NCALD HK1 PNN EIF4A3 PPP1R12A PPP1R12B IFT81 DDX42 HEATR1 ECE1 HPCA AP1AR SEPHS1 BBX N4BP2 EIF4A1 CTAGE8 NIP7 CTAGE4 ATP2B2 ATP2B3

7.19e-111442982235575683
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DHX16 RALA TENT4B GATAD2A PNN RBBP6 EIF4A3 PPP1R12A HEATR1 CMSS1 NDUFA9 EIF4A1 RRP12 NIP7 EIF2S2 PLEKHA5 EIF3B MARK2 SNRNP200

2.02e-091257981936526897
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RALA DDAH1 HK1 SEPTIN5 KALRN MARK1 PPP1R12A PPP1R12B SRCIN1 NDUFA9 KIF3A HPCA ATP6V1H EIF2S2 PLEKHA5 MARK2 ATP2B2 ATP2B3 SNRNP200 ATP2B4

2.71e-091431982037142655
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

HK1 GATAD2A PPP1R12A IFT81 LRRC40 NDUFA9 SHTN1 PPP4R3A ATP6V1H NCAPG SAP130 SNRNP200 DYNC1LI2

6.57e-09560981335241646
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DHX16 RALA HK1 TENT4B HK2 PNN EIF4A3 DDX42 LRRC40 FASTKD2 HEATR1 ATP6V1H NCAPG EIF4A1 RRP12 EIF2S2 EIF3B ATP2B3 SNRNP200

1.53e-081425981930948266
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

HK1 GATAD2A EIF4A3 DDX42 CMSS1 PPP4R3A SEPHS1 NCAPG EIF4A1 CTAGE8 EIF2S2 EIF3B SNRNP200 ATP2B4 DYNC1LI2

1.56e-08847981535235311
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

DHX16 HK2 GATAD2A PPP1R12A IFT81 HEATR1 CMSS1 INTS3 KMT2D NCAPG BBX EIF2S2 SAP130 ATP2B3 SNRNP200

1.82e-08857981525609649
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

DHX16 GATAD2A PNN RBBP6 EIF4A3 LRRC40 FASTKD2 HEATR1 NDUFA9 INTS3 NCAPG EIF4A1 RRP12 NIP7 EIF2S2 EIF3B SAP130 SNRNP200

2.69e-081318981830463901
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DHX16 HK1 HK2 GATAD2A PNN EIF4A3 LRRC40 FASTKD2 HEATR1 CMSS1 NDUFA9 NCAPG EIF4A1 RRP12 EIF2S2 PLEKHA5 EIF3B SNRNP200

4.00e-081353981829467282
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

DHX16 KDM5B HK1 PNN KALRN RBBP6 MARK1 EIF4A3 DDX42 BBX EIF4A1 RRP12 EIF2S2 EIF3B SNRNP200 DYNC1LI2

5.99e-081082981638697112
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

DHX16 TENT4B PNN RBBP6 EIF4A3 DDX42 FASTKD2 HEATR1 CMSS1 EIF4A1 RRP12 NIP7 EIF2S2 SNRNP200

6.32e-08807981422681889
Pubmed

Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498312209837
Pubmed

Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498312784250
Pubmed

Calcium pumps of plasma membrane and cell interior.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498315101689
Pubmed

The plasma membrane calcium pump in health and disease.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498323413890
Pubmed

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

ATP2B2 ATP2B3 ATP2B4

8.66e-0849838245032
Pubmed

Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498310577388
Pubmed

Structural organization, ion transport, and energy transduction of P-type ATPases.

ATP2B2 ATP2B3 ATP2B4

8.66e-0849838634322
Pubmed

Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.

ATP2B2 ATP2B3 ATP2B4

8.66e-0849837989379
Pubmed

Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498311152753
Pubmed

PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498336130203
Pubmed

Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.

ATP2B2 ATP2B3 ATP2B4

8.66e-08498310434059
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

HK1 TENT4B HK2 MARK1 EIF4A3 PPP1R12B ECE1 KIF3A STK3 SEPHS1 EIF4A1 MARK2 ATP2B4

1.44e-07730981334857952
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PPP1R12A IFT81 HEATR1 NDUFA9 KIF3A PPP4R3A STK3 BBX NEK5 RABEP1 PLEKHA5 MARK2 TMEM41B CSPP1 ATP2B2 SNRNP200 DYNC1LI2

1.61e-071321981727173435
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EMC7 HK1 IFT81 DDX42 ACBD5 LRRC40 FASTKD2 HEATR1 NDUFA9 NCAPG N4BP2 RRP12 NIP7 PLEKHA5 MARK2 CSPP1 SNRNP200 ATP2B4

1.64e-071487981833957083
Pubmed

Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.

ATP2B2 ATP2B3 ATP2B4

2.16e-07598317938178
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

TENT4B GATAD2A PNN RBBP6 EIF4A3 HEATR1 MAP3K1 EIF4A1 RRP12 EIF2S2 MARK2 SAP130 SNRNP200

2.25e-07759981335915203
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

RALA EMC7 HK2 EIF4A3 PPP1R12A ACBD5 EXTL2 CPT1A NDUFA9 ATP2B4

3.37e-07422981027342126
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

EMC7 HK2 LRRC40 HEATR1 CMSS1 CPT1A NDUFA9 ATP6V1H NCAPG RABEP1 EIF4A1 RRP12 TMEM41B ATP2B4

4.11e-07942981431073040
Pubmed

Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.

ATP2B2 ATP2B3 ATP2B4

4.31e-07698312767889
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

PNN RBBP6 PPP1R12A HEATR1 SHTN1 KMT2D NCAPG RABEP1 PLEKHA5 SAP130 SNRNP200

4.46e-07549981138280479
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

DHX16 PNN EIF4A3 KMT2D EIF4A1 EIF3B SNRNP200

5.61e-0717098716159877
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

TENT4B GATAD2A PNN RBBP6 PPP1R12A DDX42 HEATR1 CPT1A EIF4A1 RRP12 NIP7 EIF3B SNRNP200

7.73e-07847981335850772
Pubmed

Gene knockout studies of Ca2+-transporting ATPases.

ATP2B2 ATP2B3 ATP2B4

1.20e-06898310951186
Pubmed

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.

PNN MARK1 EIF4A3 PPP1R12A DDX42 CMSS1 EIF4A1 EIF2S2 MARK2 SNRNP200

1.33e-06491981036273042
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP8B2 ATP2B2 ATP2B3 ATP2B4

1.33e-062998415071553
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

DHX16 GATAD2A RBBP6 DDX42 PPP4R3A BBX EIF4A1 SNRNP200

1.45e-0628398830585729
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

HK2 GATAD2A PNN EIF4A3 LRRC40 CMSS1 CPT1A NDUFA9 INTS3 NCAPG EIF4A1 RRP12 NIP7 EIF2S2 EIF3B SNRNP200

2.11e-061415981628515276
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

PNN RBBP6 EIF4A3 PPP1R12A PPP1R12B HEATR1 CMSS1 EIF4A1 RRP12 EIF2S2 EIF3B MARK2 SNRNP200

2.71e-06949981336574265
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

UNC13B HK1 PNN PPP1R12A MAP3K1 KIF3A NCAPG EIF4A1 EIF2S2 EIF3B SNRNP200

3.07e-06670981122990118
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

GATAD2A PNN RBBP6 EIF4A3 DDX42 HEATR1 CPT1A INTS3 KMT2D BBX RRP12 NIP7 TMEM41B SAP130 SNRNP200

3.38e-061294981530804502
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

TENT4B SEPTIN5 RBBP6 PPP1R12A PPP1R12B ACBD5 HEATR1 CMSS1 NDUFA9 BBX EIF4A1 RRP12 NIP7 EIF2S2 EIF3B MARK2

4.33e-061497981631527615
Pubmed

Defining the membrane proteome of NK cells.

HK2 PNN EIF4A3 DDX42 ACBD5 LRRC40 HEATR1 CPT1A ECE1 NCAPG EIF4A1 PLEKHA5 ATP2B4 DYNC1LI2

5.07e-061168981419946888
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

PNN EIF4A3 DDX42 LRRC40 INTS3 NCAPG EIF4A1 MARK2 SNRNP200 DYNC1LI2

5.97e-06582981020467437
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DHX16 RALA GATAD2A PNN EIF4A3 DDX42 LRRC40 HEATR1 EIF4A1 RRP12 EIF3B MARK2 SNRNP200

6.16e-061024981324711643
Pubmed

Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10.

KDM5B KLF10

7.86e-06298220863814
Pubmed

Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser.

PPP1R12A PPP1R12B

7.86e-06298210200412
Pubmed

Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26-->p25 and Xq28, respectively.

ATP2B2 ATP2B3

7.86e-0629828187550
Pubmed

Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases.

PPP1R12A PPP1R12B

7.86e-06298210087910
Pubmed

Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.

ATP2B2 ATP2B4

7.86e-0629821313367
Pubmed

Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.

ATP2B3 ATP2B4

7.86e-0629821531651
Pubmed

Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes.

HK1 CPT1A

7.86e-06298225501281
Pubmed

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.

UNC13B UNC13C

7.86e-06298222674279
Pubmed

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.

MARK1 MARK2

7.86e-06298216803889
Pubmed

Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury.

HK1 HK2

7.86e-06298224990892
Pubmed

Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.

ATP2B2 ATP2B4

7.86e-06298222252018
Pubmed

Plasma membrane Ca²⁺-ATPases can shape the pattern of Ca²⁺ transients induced by store-operated Ca²⁺ entry.

ATP2B2 ATP2B4

7.86e-06298225690014
Pubmed

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.

HK1 HK2

7.86e-06298221504994
Pubmed

Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.

ATP2B2 ATP2B4

7.86e-06298216216224
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

RALA EMC7 MARK1 PPP1R12B HEATR1 CMSS1 STK3 PLEKHA5 EIF3B MARK2 ATP2B4

9.36e-06754981133060197
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

HK2 GATAD2A LRRC40 HEATR1 INTS3 NCAPG EIF2S2 MARK2

1.04e-0537098822922362
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DHX16 PNN RBBP6 INTS3 PPP4R3A KMT2D RRP12 EIF3B MARK2 SNRNP200 DYNC1LI2

1.19e-05774981115302935
Pubmed

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

PPP1R12A EXTL2 CMSS1 CPT1A TEX11 CLHC1 EIF4A1 EIF2S2 PLEKHA5

1.30e-0550398936217030
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

GATAD2A PNN KALRN RBBP6 KLF10 RRP12 PLEKHA5 MARK2 DYNC1LI2

1.30e-0550398916964243
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

DHX16 HK2 PNN EIF4A3 HEATR1 NCAPG RRP12 EIF2S2 EIF3B SNRNP200

1.38e-05641981036057605
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

GATAD2A PNN RBBP6 CPT1A PPP4R3A BBX RRP12 NIP7 SAP130 SNRNP200

1.66e-05655981035819319
Pubmed

The functional interactome landscape of the human histone deacetylase family.

GATAD2A PNN HEATR1 CPT1A BBX RRP12 SAP130

1.85e-0528998723752268
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

HK1 HK2 GATAD2A PNN RBBP6 DDX42 NDUFA9 RRP12 SAP130 SNRNP200

1.89e-05665981030457570
Pubmed

Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth.

KSR2 CPT1A NDUFA9 ATP6V1H

1.95e-055698435918402
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

GATAD2A PNN RBBP6 NCAPG EIF3B SNRNP200

1.97e-0519598619454010
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

RBBP6 EIF4A3 CMSS1 NDUFA9 EIF4A1 RRP12 NIP7 PLEKHA5 MARK2 SNRNP200

2.23e-05678981030209976
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

UNC13B GATAD2A EIF4A3 PPP1R12A FASTKD2 NDUFA9 STK3 NCAPG WDR87 EIF4A1 RRP12 EIF2S2 EIF3B SNRNP200

2.26e-051335981429229926
Pubmed

[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].

HK1 HK2

2.35e-05398226855992
Pubmed

Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress.

HK1 HK2

2.35e-05398221430642
Pubmed

Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.

HK1 HK2

2.35e-05398230871777
Pubmed

Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction.

NCALD HPCA

2.35e-05398211836243
Pubmed

Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.

PPP1R12A PPP1R12B

2.35e-05398210567269
Pubmed

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

UNC13B UNC13C

2.35e-05398223658173
Pubmed

PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis.

PLEKHA5 ATP2B4

2.35e-05398233355366
Pubmed

Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.

HK1 HK2

2.35e-05398233525649
Pubmed

Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.

HK1 HK2

2.35e-05398219049977
Pubmed

The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells.

ATP2B2 ATP2B4

2.35e-05398217689535
Pubmed

Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells.

ATP2B2 ATP2B4

2.35e-05398220211863
Pubmed

Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1.

PPP1R12A PPP1R12B

2.35e-05398220801872
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13B UNC13C

2.35e-05398233105896
Pubmed

A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.

HK1 HK2

2.35e-05398220347420
Pubmed

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.

UNC13B UNC13C

2.35e-05398222966208
Pubmed

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.

HK1 HK2

2.35e-05398228054552
Pubmed

Translational repression precedes and is required for ZAP-mediated mRNA decay.

EIF4A1 EIF3B

2.35e-05398223023399
Pubmed

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.

MARK1 MARK2

2.35e-0539829108484
Pubmed

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.

UNC13B UNC13C

2.35e-05398215988013
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

HEATR1 CPT1A RRP12 ATP2B2 ATP2B3 SNRNP200

2.41e-0520298624639526
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

DDAH1 HK1 SEPTIN5 KALRN SRCIN1 PLEKHH1 SNRNP200

2.55e-0530498732235678
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

DHX16 GATAD2A PNN RBBP6 EIF4A3 DDX42 PPP4R3A NCAPG EIF4A1 EIF2S2 EIF3B SAP130

2.87e-051014981232416067
Pubmed

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

UNC13B IFT81 PPP4R3A ATP6V1H ATP2B2 ATP2B3

2.91e-0520998626389662
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

PNN RBBP6 EIF4A3 FASTKD2 CMSS1 BBX RRP12 NIP7 EIF2S2 SNRNP200

3.41e-05713981029802200
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

HK1 HK2 LRRC40 CMSS1 NDUFA9 ATP6V1H NCAPG

3.75e-0532398724797263
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

DHX16 PNN RBBP6 EIF4A3 DDX42 FASTKD2 NDUFA9 KIF3A EIF4A1 NIP7

3.83e-05723981034133714
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

PNN RBBP6 EIF4A3 HEATR1 CMSS1 RRP12 NIP7 EIF2S2 EIF3B SNRNP200

4.20e-05731981029298432
Pubmed

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.

NDUFA9 SHTN1 KIF3A ATP6V1H NCAPG RABEP1 CSPP1

4.46e-0533298729053956
InteractionCYP2B6 interactions

ATP2B2 ATP2B3 ATP2B4

5.95e-068973int:CYP2B6
InteractionC9orf78 interactions

HK1 GATAD2A PPP1R12A IFT81 LRRC40 NDUFA9 SHTN1 PPP4R3A ATP6V1H NCAPG SAP130 SNRNP200 DYNC1LI2

8.50e-066209713int:C9orf78
InteractionKCTD13 interactions

RALA DDAH1 HK1 SEPTIN5 KALRN MARK1 PPP1R12A PPP1R12B SRCIN1 NDUFA9 KIF3A HPCA ATP6V1H EIF2S2 PLEKHA5 MARK2 ATP2B2 ATP2B3 SNRNP200 ATP2B4

8.77e-0613949720int:KCTD13
InteractionC17orf78 interactions

ATP2B2 ATP2B3 ATP2B4

2.30e-0512973int:C17orf78
InteractionTPP2 interactions

NCALD HK2 PPP1R12A PPP1R12B HPCA EIF3B

2.62e-05121976int:TPP2
InteractionTPST2 interactions

HEATR1 INTS3 KLHL13 ATP2B2 ATP2B3 ATP2B4

3.01e-05124976int:TPST2
InteractionSOX2 interactions

KDM5B HK1 GATAD2A MARK1 EIF4A3 PPP1R12A KSR2 HEATR1 CMSS1 INTS3 SEPHS1 KMT2D ATP6V1H EIF4A1 RRP12 NIP7 EIF2S2 MARK2 SAP130

4.10e-0514229719int:SOX2
InteractionHSD17B6 interactions

ATP2B2 ATP2B3 ATP2B4

4.72e-0515973int:HSD17B6
Cytoband8q22.2

NCALD STK3 KLF10

1.62e-05239838q22.2
Cytoband1q32.1

KDM5B PPP1R12B RHEX ATP2B4

8.82e-051089841q32.1
GeneFamilyATPases Ca2+ transporting

ATP2B2 ATP2B3 ATP2B4

2.46e-0695731209
GeneFamilyCTAGE family

CTAGE9 CTAGE8 CTAGE4

1.32e-0515573907
GeneFamilyUNC13 homologs

UNC13B UNC13C

5.84e-054572836
GeneFamilyMOB kinase activators|STRIPAK complex

MOB3A MOB3B

2.03e-047572647
GeneFamilyDEAD-box helicases

EIF4A3 DDX42 EIF4A1

3.13e-0442573499
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEB2 POTEB

7.45e-0413572685
CoexpressionCAIRO_HEPATOBLASTOMA_CLASSES_UP

EIF4A3 DDX42 HEATR1 ATP6V1H NCAPG EIF4A1 NIP7 EIF2S2 EIF3B SAP130 SNRNP200

1.66e-056129711M4772
CoexpressionMONNIER_POSTRADIATION_TUMOR_ESCAPE_UP

SPIRE2 GATAD2A PNN PPP1R12B AP1AR BBX RRP12 EIF3B DYNC1LI2

2.10e-05408979M11891
CoexpressionMONNIER_POSTRADIATION_TUMOR_ESCAPE_UP

SPIRE2 GATAD2A PNN PPP1R12B AP1AR BBX RRP12 EIF3B DYNC1LI2

2.40e-05415979MM1028
ToppCellPBMC-Severe-cDC_11|Severe / Compartment, Disease Groups and Clusters

NCALD KALRN ECE1 ADCY1 RHEX PLEKHA5

2.74e-061789860667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

NCALD DDAH1 KALRN PPP1R12A PPP1R12B UNC13C

3.76e-0618898634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHTN1 MAP3K1 RHEX KLHL13 MOB3B NRG3

3.88e-06189986aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHTN1 MAP3K1 RHEX KLHL13 MOB3B NRG3

3.88e-061899868977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13B DDAH1 KALRN PLEKHA5 NRG3 ATP2B2

4.64e-061959862e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCALD KALRN KSR2 PLEKHA5 NRG3 ATP2B2

5.06e-06198986c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCALD KALRN KSR2 PLEKHA5 NRG3 ATP2B2

5.06e-061989866d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCALD KALRN KSR2 PLEKHA5 NRG3 ATP2B2

5.06e-061989868ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN KSR2 KIF3A PLEKHA5 NRG3 ATP2B2

5.06e-061989860ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellhuman_hepatoblastoma-Tumor_cells-T9|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

HK2 GATAD2A EIF4A3 RRP12 EIF3B TMEM41B

5.21e-06199986e9c83555d2197b740797a9f33b64f8f7a7ba1ee2
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX11 SRCIN1 CMSS1 CLHC1 ZFYVE28

3.61e-051699853f738fc56bbc70dc77c9ba41025631f8264cd2b3
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

KALRN HEMGN EXTL2 PLEKHH1 RRP12

3.71e-0517098509bcbc7eb3b1d35cf03f01ce2f2fe37373382dd4
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NCALD ECE1 ADCY1 RHEX PLEKHA5

4.15e-05174985991f7eab69ea3ee1045a4e44ce60a96db13df6d1
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NCALD ECE1 ADCY1 RHEX PLEKHA5

4.15e-05174985c8cec89369cf3896c5626e447051e76a142cb6df
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DDAH1 EIF4A3 EIF4A1 EIF2S2 EIF3B

5.27e-05183985523896bd1a93bdda81a009768baa3a1bdbd108b8
ToppCellCerebellum-Neuronal|Cerebellum / BrainAtlas - Mouse McCarroll V32

SPIRE2 KSR2 ZFYVE28 HPCA NRG3

5.84e-0518798561b9d6eb131a674598aa8409d7fa909c8765442d
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

UNC13B NCALD KALRN CSPP1 ATP2B4

5.99e-051889851aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

NCALD DDAH1 KALRN PPP1R12A UNC13C

6.14e-051899856b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SRCIN1 MAP3K1 RHEX KLF10 NRG3

6.14e-05189985bd91bdfe35294e60d980259b70fe9e60dca2743f
ToppCellpdx-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CPT1A ECE1 RHEX NRG3 ATP2B2

6.30e-05190985b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NCALD N4BP2 PLEKHA5 EIF3B CSPP1

6.45e-0519198539ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

KSR2 KIF3A NRG3 ATP2B2 ATP2B3

6.61e-051929854c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCellfacs-Thymus-Flowthrough-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEMGN LRRC40 SEPHS1 NCAPG KLF10

6.61e-05192985e8d47504b744040a762ec9b670a66cc060b2ae86
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN SRCIN1 ADCY1 ATP2B2 ATP2B4

6.78e-05193985be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN SRCIN1 ADCY1 ATP2B2 ATP2B4

6.78e-051939850c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KALRN SRCIN1 ADCY1 ATP2B2 ATP2B4

6.78e-051939858689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCALD KALRN HPCA UNC13C ATP2B2

7.12e-05195985787e95fb59c40bba784544b662fac37606ae1427
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN KSR2 PLEKHA5 NRG3 ATP2B2

7.29e-05196985676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN KSR2 PLEKHA5 NRG3 ATP2B2

7.65e-051989854ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellmyeloid-Dendritic_cell-Conventional_dendritic_cell|myeloid / Lineage, cell class and subclass

RALA PNN EIF4A3 EIF4A1 PLEKHA5

7.83e-051999851e7ce1a1d6a7af18351d64b7a5334efa6dd9abc5
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CMSS1 SEPHS1 RRP12 NIP7 EIF2S2

7.83e-05199985cdcdef1d95a8e476de016b1e11ee010438834be0
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

SOX11 SHTN1 ADCY1 KIF3A HPCA

7.83e-051999850cd3e4e0fba000c996feaf012ff32198e1048c9d
ToppCellmyeloid-Dendritic_cell|myeloid / Lineage, cell class and subclass

RALA PNN EIF4A3 EIF4A1 PLEKHA5

7.83e-05199985b81c0a40481f1006ac4aa8759af95448cb5fc2e6
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

SOX11 KALRN SRCIN1 SHTN1 ADCY1

8.02e-05200985bad32a95b759fad509401b07bc96a56687c2a592
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

KALRN KSR2 PLEKHA5 NRG3 ATP2B2

8.02e-0520098548d801219bc771d6c7e151dc88ca4c179988de85
DrugDCCD

HK1 HK2 ADCY1 ATP6V1H ATP2B2 ATP2B3 ATP2B4

3.33e-06151957CID000010868
DrugAC1NSKPI

EIF4A3 EIF4A1 ATP2B2 ATP2B3 ATP2B4

4.01e-0657955CID005311482
Drug1sqc

ATP2B2 ATP2B3 ATP2B4

8.27e-0610953CID000444279
Drug2,5-dimethylquinone

ATP2B2 ATP2B3 ATP2B4

1.13e-0511953CID000008718
Drug1vyq

ATP2B2 ATP2B3 ATP2B4

1.51e-0512953CID004369390
DrugRo 46861

ATP2B2 ATP2B3 ATP2B4

1.51e-0512953CID000003128
DrugN-Formyl-Met-Val

EIF4A3 EIF4A1

1.72e-052952CID000100136
Drug8-hydroxycoumarin

ATP2B2 ATP2B3 ATP2B4

1.95e-0513953CID000122783
Drugp-hydroxyhippuric acid

ATP2B2 ATP2B3 ATP2B4

2.48e-0514953CID000151012
DrugAC1L88YH

ATP2B2 ATP2B3 ATP2B4

4.59e-0517953CID000374551
Drugethylmethylamine

HK1 PPP1R12A ADCY1 MAP3K1

5.22e-0549954CID000012219
Drug2-(aminomethyl)pyrrolidine

HK1 HK2 ADCY1 ATP2B2 ATP2B3 ATP2B4

5.89e-05161956CID000072032
DrugAICAR monophosphate

HK1 HK2 MARK1 PPP1R12A CPT1A MARK2

6.31e-05163956CID000000200
Drugo-toluidine

RALA HK1 HK2

7.62e-0520953CID000007242
DrugAC1L1IIA

HK1 HK2 ATP6V1H ATP2B2 ATP2B3 ATP2B4

8.49e-05172956CID000004591
DrugNSC638615

RALA HK1 HK2 MARK2 REPS2

8.64e-05107955CID000097535
Drug2brh

ATP2B2 ATP2B3 ATP2B4

8.86e-0521953CID000848641
DrugICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A_EA

RBBP6 PPP1R12A RABEP1 EIF4A1 CSPP1 DYNC1LI2

9.94e-05177956985_DN
Drug2,3-anhydro-D-allose

HK1 HK2

1.03e-044952CID000191595
Druglofenal

HK1 HK2

1.03e-044952CID000159256
DrugN-bromoacetylglucosamine

HK1 HK2

1.03e-044952CID000152920
Drug1,5-anhydroglucitol 6-phosphate

HK1 HK2

1.03e-044952CID003081444
Drug1-deoxy-D-manno-heptulose

HK1 HK2

1.03e-044952CID000193198
DrugAC1L5VHN

HK1 HK2

1.03e-044952CID000235938
DrugAC1L25Y6

ATP2B2 ATP2B3 ATP2B4

1.17e-0423953CID000015465
Druglanthanum chloride hydrate

ATP2B2 ATP2B3 ATP2B4

1.17e-0423953CID000165791
DrugMgCl2

DHX16 HK1 HK2 ADCY1 BPI ATP2B2 ATP2B3 ATP2B4

1.18e-04354958CID000024584
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

PPP1R12A STK3 NCAPG BBX PLEKHA5 SAP130

1.19e-041839567498_DN
DiseaseHailey-Hailey disease (implicated_via_orthology)

ATP2B2 ATP2B3 ATP2B4

5.45e-076903DOID:0050429 (implicated_via_orthology)
Diseasevisual impairment and progressive phthisis bulbi (implicated_via_orthology)

MARK1 MARK2

5.50e-054902DOID:0070356 (implicated_via_orthology)
Diseaseprogressive supranuclear palsy

HK1 ATP2B2 ATP2B4

1.16e-0431903MONDO_0019037
Diseaseperiprosthetic osteolysis

NCALD SRCIN1

1.37e-046902EFO_0009761
Diseasememory performance

UNC13B SPIRE2 HEATR1 ZFYVE28 N4BP2 UNC13C

1.60e-03409906EFO_0004874
Diseaselongevity

SPIRE2 KALRN TEX15 ECE1 ZFYVE28

1.80e-03284905EFO_0004300
Diseasealcohol use disorder (implicated_via_orthology)

UNC13B KDM5B ADCY1 UNC13C

3.04e-03195904DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KASKELVERRRTMME

EIF3B

741

P55884
IMAIKMEDPKEIRKE

BBX

381

Q8WY36
EPRSFKMTSLDKMDR

CTAGE4

641

Q8IX94
EPRSFKMTSLDKMDR

CTAGE8

641

P0CG41
EPRSFKMTSLDKMDR

CTAGE9

641

A4FU28
MLSKTMDKENRPEAV

CCDC7

221

Q96M83
ETMPMTEKVEELLRV

ACBD5

126

Q5T8D3
DQKLRRMMDIPEIRK

CMSS1

241

Q9BQ75
RMMDIPEIRKEVFEL

CMSS1

246

Q9BQ75
RPLMKEEDFKRMTAL

CPT1A

191

P50416
MNRMLPMRERSKTEE

AP1AR

216

Q63HQ0
IDGMKMEKSPLREEA

CER1

116

O95813
RLKMAEEDRKAMVPE

DHX16

211

O60231
EEDRKAMVPELRKKS

DHX16

216

O60231
RDRDEMVKKVIEPMA

ATP2B2

651

Q01814
DRDDMVRKIIEPMAC

ATP2B3

626

Q16720
NKDRDDMVRTVIEPM

ATP2B4

616

P23634
LEVREELRKAREKMM

ATP8B2

726

P98198
LMREIRARKMEDSKE

RALA

171

P11233
AEKLRSVVMPMEKEI

RABEP1

181

Q15276
LQLRREKPSEEMVKM

INTS3

846

Q68E01
EKPSEEMVKMVLSRP

INTS3

851

Q68E01
MKMPEDESTPEKRTE

HPCA

136

P84074
DDDIMDPISKFMERK

PPP4R3A

706

Q6IN85
PRKDLIVMLRDTDMN

POTEB2

116

H3BUK9
NRELESMAMRPLAKE

ZFYVE28

116

Q9HCC9
RKELEPLKEMTSRMC

MOB3B

201

Q86TA1
MDARRMKKEEGLTEN

CDRT4

1

Q8N9R6
KVERHPVTALEKMME

NRG3

431

P56975
EALMKSSPEERERMI

GATAD2A

131

Q86YP4
MSPRPEEEKMRMEVV

TENT4B

131

Q8NDF8
REPIMKADMLKVVDE

MAGEB1

126

P43366
DTKELEPLKEMTARM

MOB3A

201

Q96BX8
EERPTFTKLMDMLEK

KSR2

916

Q6VAB6
MPQKERESIMKEFRS

EIF4A3

311

P38919
DKMKIPPEKMRELER

DYNC1LI2

161

O43237
PSVKEDKMLMLRREI

EXTL2

41

Q9UBQ6
EVKRRMKVEMERGLS

HK2

486

P52789
RKEAFNRESKMEPKM

DDX42

886

Q86XP3
MPSDVLEVTKKFMRD

EIF4A1

216

P60842
MEARPRRQSMKEKEH

PNN

281

Q9H307
KEIKNAMRKAMERDP

OR5A2

296

Q8NGI9
MKEIRKKMGREPEEN

NEK5

481

Q6P3R8
PIRKKERNPMDIFDM

CSPP1

971

Q1MSJ5
MKRIEEKGVPEDMRG

KALRN

1956

O60229
AKRMRAEAMNIKIEP

KDM5B

231

Q9UGL1
VVRDLREMPLDKMVD

LRRC10

21

Q5BKY1
PDKMIEMQAKIDEER

KIF3A

416

Q9Y496
EVKKRMRAEMELGLR

HK1

486

P19367
IMREKNPDMVAGEKR

EIF2S2

186

P20042
RDKVERMHITDMKLP

NDUFA9

316

Q16795
DMAKREDLAPKMCQE

HEMGN

221

Q9BXL5
KRKMEPDTEKMDRTP

RBBP6

1181

Q7Z6E9
AMEMKEDFLKPPERI

ADCY1

276

Q08828
VDIREEMPEQTAKRM

IFT81

51

Q8WYA0
RLEEPRMDFAAKLMK

KLHL13

266

Q9P2N7
VLKMTLRDDMIPKES

BPI

306

P17213
MMRPVEVRKEEITLK

DRC7

31

Q8IY82
SMDPNDMMREIRKVL

MARK1

711

Q9P0L2
EPNEMMREIRKVLDA

MARK2

706

Q7KZI7
TAEERMEMISERPKE

KLF10

11

Q13118
ISKERAEALMMPLVD

HEATR1

2011

Q9H583
KVVNTSDPDMRREME

EMC7

181

Q9NPA0
MNETRIEELRAKPLM

ECE1

186

P42892
MKMPEDESTPEKRTE

NCALD

136

P61601
PSRRKEVDMMKEALE

DDAH1

96

O94760
PKRMVELKEMVSDVD

LRRC40

441

Q9H9A6
KGLHKMDDRPEERMI

MAP3K1

171

Q13233
MDDRPEERMIREKLK

MAP3K1

176

Q13233
EERMIREKLKATCMP

MAP3K1

181

Q13233
KIERRKIMEQSPDMH

SOX11

61

P35716
QRFEMKRSPEEKQEM

ATP6V1H

51

Q9UI12
KEMKETQTERDIPMS

RHEX

66

Q6ZWK4
TEKLIRMKDEELRRM

SEPTIN5

341

Q99719
MKEMELLRRLEEPRT

TOGARAM2

366

Q6ZUX3
MRPLTEEETRVMFEK

NIP7

1

Q9Y221
PRKDLIVMLRDTDMN

POTEB

116

A0A0A6YYL3
LMDLFMKRIVEDPES

FASTKD2

436

Q9NYY8
KMTDRERDKVMPLII

SEPHS1

131

P49903
EEMMDRIKKGVHLRP

SHTN1

411

A0MZ66
ERTFMRDTIMKLPEK

ABCC12

1231

Q96J65
EEMADPMEDVIIRNK

RRP12

1176

Q5JTH9
MEDDPRRAKEAEIML

CLHC1

281

Q8NHS4
EPESEMKMRLPRRAK

NCAPG

981

Q9BPX3
RLKALDPMMEREIEE

STK3

451

Q13188
MKERMKIREKNRPEV

UNC13C

1171

Q8NB66
PRDLNRMEKTSVKDM

REPS2

396

Q8NFH8
RMEKTSVKDMADLPV

REPS2

401

Q8NFH8
AKDTETRERMEAMEK

SRCIN1

561

Q9C0H9
RVLLKAPTLAEMEEM

SPIRE2

406

Q8WWL2
EIKVKEEVEPMDIMR

SAP130

781

Q9H0E3
LDPEEMKRKMREDVI

TOMM5

11

Q8N4H5
AEMPESEDKKKEMDR

TEX11

591

Q8IYF3
MKDRMKIRERNKPEI

UNC13B

551

O14795
SRARSREEPEKMEME

PLEKHH1

366

Q9ULM0
AEKERIMGKMEADPE

SNRNP200

341

O75643
KSIKDPRLMRREESM

TEX15

46

Q9BXT5
EERVNMKVPRDMDDA

TMEM41B

81

Q5BJD5
MDKERNKDKMPEDVT

PLEKHA5

1021

Q9HAU0
EMKRLAEEKMRLVEG

WDR87

1966

Q6ZQQ6
PRKFLGTMDKEREVM

WDR87

2426

Q6ZQQ6
RIIEPVAAMRKEADM

KMT2D

5266

O14686
IMEKRPEEESEDSKM

N4BP2

116

Q86UW6
ERRISEMEEELKMLP

PPP1R12A

991

O14974
KRERRALERKMSEME

PPP1R12B

936

O60237