Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF384 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 EZH2 ZNF416 ZNF548 ZNF529 RXRA ZNF354C RXRB CASZ1 ZNF710 ZNF77

9.53e-0914598123GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF384 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF841 ZNF236 ZNF416 ZNF548 ZNF529 RXRA ZNF354C RXRB CASZ1 ZNF77

6.21e-0714128120GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF384 ZNF573 ZFAT ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF362 ZNF841 ZNF236 EZH2 ZNF416 ZNF548 RXRA ZNF354C RXRB ZNF710

1.89e-0612448118GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF384 ZNF573 ZFAT ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF362 ZNF841 ZNF236 EZH2 ZNF416 ZNF548 RXRA ZNF354C RXRB ZNF710

2.56e-0612718118GO:0000987
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH17 DNAH2 DNAH9

5.02e-0518813GO:0008569
GeneOntologyMolecularFunctionhistone H4K20 demethylase activity

PHF2 PHF8

9.70e-054812GO:0035575
GeneOntologyMolecularFunctionhistone H4 demethylase activity

PHF2 PHF8

1.61e-045812GO:0141058
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH17 DNAH2 DNAH9

1.96e-0428813GO:0051959
GeneOntologyMolecularFunctionzinc ion binding

PHF2 ZMAT5 ZNF326 TUT4 USP51 TRPS1 KMT2A PHF14 PHF8 RXRA RXRB ZMYM4

2.40e-048918112GO:0008270
GeneOntologyMolecularFunctionretinoic acid-responsive element binding

RXRA RXRB

3.37e-047812GO:0044323
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH17 DNAH2 DNAH9

4.52e-0437813GO:0045505
GeneOntologyMolecularFunctionunmethylated CpG binding

KMT2A TLR9

7.16e-0410812GO:0045322
GeneOntologyMolecularFunctionhistone binding

PHF2 USP51 ATRX KMT2A PHF14 PHF8

7.29e-04265816GO:0042393
GeneOntologyMolecularFunctiontransition metal ion binding

PHF2 ZMAT5 ZNF326 TUT4 ATP2C1 USP51 TRPS1 KMT2A PHF14 PHF8 RXRA RXRB ZMYM4

9.46e-0411898113GO:0046914
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

1.04e-0312812GO:0030023
GeneOntologyMolecularFunctionhistone H3K9 demethylase activity

PHF2 PHF8

1.43e-0314812GO:0032454
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

1.43e-0314812GO:0097493
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

RXRA RXRB

2.38e-0318812GO:0042809
GeneOntologyMolecularFunctionhistone modifying activity

PHF2 USP51 KMT2A PHF8 EZH2

2.40e-03229815GO:0140993
GeneOntologyBiologicalProcessnegative regulation of heterochromatin formation

PHF2 KMT2A PHF8

1.11e-066803GO:0031452
GeneOntologyBiologicalProcessnegative regulation of chromatin organization

PHF2 KMT2A PHF8

1.94e-067803GO:1905268
GeneOntologyBiologicalProcessnegative regulation of rDNA heterochromatin formation

PHF2 PHF8

1.49e-052802GO:0061188
GeneOntologyBiologicalProcessregulation of rDNA heterochromatin formation

PHF2 PHF8

4.45e-053802GO:0061187
GeneOntologyBiologicalProcessfacultative heterochromatin formation

PHF2 KMT2A PHF8 EZH2

6.16e-0555804GO:0140718
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

8.87e-054802GO:0035583
GeneOntologyBiologicalProcessnegative regulation of amacrine cell differentiation

GDF11 CASZ1

8.87e-054802GO:1902870
GeneOntologyBiologicalProcessregulation of heterochromatin formation

PHF2 KMT2A PHF8

1.07e-0424803GO:0031445
GeneOntologyBiologicalProcesspositive regulation of vitamin D receptor signaling pathway

RXRA RXRB

2.21e-046802GO:0070564
GeneOntologyCellularComponentdynein complex

DNAH17 DNAH2 DCTN4 DNAH9

5.18e-0554794GO:0030286
GeneOntologyCellularComponentaxonemal dynein complex

DNAH17 DNAH2 DNAH9

1.13e-0425793GO:0005858
Domainzf-C2H2

ZNF462 ZNF384 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

8.67e-146938022PF00096
DomainZINC_FINGER_C2H2_1

ZNF462 ZNF384 ZNF573 TUT4 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

9.12e-147778023PS00028
DomainZnf_C2H2-like

ZNF462 ZNF384 ZNF326 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

1.51e-137968023IPR015880
DomainZnf_C2H2

ZNF462 ZNF384 ZNF326 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

1.91e-138058023IPR007087
DomainZnF_C2H2

ZNF462 ZNF384 ZNF326 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

2.07e-138088023SM00355
DomainZINC_FINGER_C2H2_2

ZNF462 ZNF384 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

8.17e-137758022PS50157
Domain-

ZNF462 ZNF384 ZNF573 ZFAT ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C ZNF710 ZNF77

5.63e-1267980203.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF462 ZNF384 ZNF573 ZFAT ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C ZNF710 ZNF77

8.37e-126948020IPR013087
Domainzf-C2H2_6

ZNF384 ZNF573 ZNF780A ZNF616 ZNF749 ZNF841 ZNF236 ZNF416 ZNF548 ZNF354C ZNF710 ZNF77

8.97e-093148012PF13912
DomainKRAB

ZNF573 ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF416 ZNF548 ZNF529 ZNF354C ZNF77

3.83e-083588012PS50805
DomainKRAB

ZNF573 ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF416 ZNF548 ZNF529 ZNF354C ZNF77

3.83e-083588012PF01352
DomainKRAB

ZNF573 ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF416 ZNF548 ZNF529 ZNF354C ZNF77

5.33e-083698012SM00349
DomainKRAB

ZNF573 ZNF780A ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF416 ZNF548 ZNF529 ZNF354C ZNF77

5.49e-083708012IPR001909
DomainFBN

FBN1 FBN2

5.42e-053802IPR011398
DomainZF_PHD_2

PHF2 ATRX KMT2A PHF14 PHF8

5.45e-0595805PS50016
DomainZF_PHD_1

PHF2 ATRX KMT2A PHF14 PHF8

5.73e-0596805PS01359
DomainFAD-bd

MICAL2 MICAL3

2.69e-046802IPR002938
DomainFAD_binding_3

MICAL2 MICAL3

2.69e-046802PF01494
DomainWxxW_domain

MUC5B CEMIP

2.69e-046802IPR025155
DomainMucin2_WxxW

MUC5B CEMIP

2.69e-046802PF13330
DomainPHD

PHF2 KMT2A PHF14 PHF8

3.01e-0475804PF00628
DomainZnf_PHD-finger

PHF2 KMT2A PHF14 PHF8

3.67e-0479804IPR019787
DomainTB

FBN1 FBN2

3.75e-047802PF00683
DomainZnf_FYVE_PHD

PHF2 ATRX KMT2A PHF14 PHF8

4.22e-04147805IPR011011
DomainDHC_N1

DNAH2 DNAH9

4.99e-048802PF08385
Domain-

FBN1 FBN2

4.99e-0488023.90.290.10
DomainDynein_heavy_dom-1

DNAH2 DNAH9

4.99e-048802IPR013594
DomainEGF_CA

FBN1 FBN2 SVEP1 NPNT

5.08e-0486804PF07645
DomainPHD

PHF2 KMT2A PHF14 PHF8

5.78e-0489804SM00249
DomainZnf_PHD

PHF2 KMT2A PHF14 PHF8

6.29e-0491804IPR001965
DomainTB

FBN1 FBN2

6.40e-049802PS51364
DomainTB_dom

FBN1 FBN2

6.40e-049802IPR017878
Domain-

PHF2 USP51 ATRX COP1 KMT2A PHF14 PHF8 CNOT4

6.69e-044498083.30.40.10
DomainZnf_RING/FYVE/PHD

PHF2 USP51 ATRX COP1 KMT2A PHF14 PHF8 CNOT4

7.72e-04459808IPR013083
DomainRetinoid-X_rcpt/HNF4

RXRA RXRB

7.97e-0410802IPR000003
DomainEGF_Ca-bd_CS

FBN1 FBN2 SVEP1 NPNT

7.99e-0497804IPR018097
DomainEGF_CA

FBN1 FBN2 SVEP1 NPNT

8.63e-0499804PS01187
DomainASX_HYDROXYL

FBN1 FBN2 SVEP1 NPNT

8.96e-04100804PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN1 FBN2 SVEP1 NPNT

1.11e-03106804IPR000152
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH9

1.59e-0314802IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH9

1.59e-0314802IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH9

1.59e-0314802IPR013602
DomainDHC_N2

DNAH2 DNAH9

1.59e-0314802PF08393
DomainMT

DNAH2 DNAH9

1.59e-0314802PF12777
DomainAAA_8

DNAH2 DNAH9

1.59e-0314802PF12780
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH9

1.59e-0314802IPR011704
DomainAAA_5

DNAH2 DNAH9

1.59e-0314802PF07728
DomainDHC_fam

DNAH2 DNAH9

1.83e-0315802IPR026983
DomainDynein_heavy_dom

DNAH2 DNAH9

1.83e-0315802IPR004273
DomainDynein_heavy

DNAH2 DNAH9

1.83e-0315802PF03028
DomainEGF_CA

FBN1 FBN2 SVEP1 NPNT

1.87e-03122804SM00179
Domain-

TRPS1 RXRA RXRB

1.87e-03578033.30.50.10
DomainZnf_CCCH

PPP1R10 ZMAT5 CNOT4

1.97e-0358803IPR000571
DomainZnf_NHR/GATA

TRPS1 RXRA RXRB

1.97e-0358803IPR013088
DomainZF_C3H1

PPP1R10 ZMAT5 CNOT4

1.97e-0358803PS50103
DomainEGF-like_Ca-bd_dom

FBN1 FBN2 SVEP1 NPNT

1.98e-03124804IPR001881
DomainGATA_ZN_FINGER_1

ATRX TRPS1

2.09e-0316802PS00344
DomainGATA_ZN_FINGER_2

ATRX TRPS1

2.09e-0316802PS50114
DomainZinc_finger_PHD-type_CS

PHF2 PHF14 PHF8

2.73e-0365803IPR019786
DomainCH

MICAL2 MICAL3 VAV2

2.73e-0365803SM00033
DomainLIM

PDLIM7 MICAL2 MICAL3

3.24e-0369803PF00412
Domain-

PDLIM7 MICAL2 MICAL3

3.37e-03708032.10.110.10
DomainCH

MICAL2 MICAL3 VAV2

3.37e-0370803PF00307
DomainZnf_LIM

PDLIM7 MICAL2 MICAL3

3.51e-0371803IPR001781
DomainLIM_DOMAIN_1

PDLIM7 MICAL2 MICAL3

3.51e-0371803PS00478
DomainLIM_DOMAIN_2

PDLIM7 MICAL2 MICAL3

3.51e-0371803PS50023
Domain-

MICAL2 MICAL3 VAV2

3.51e-03718031.10.418.10
DomainLIM

PDLIM7 MICAL2 MICAL3

3.51e-0371803SM00132
DomainCH

MICAL2 MICAL3 VAV2

3.79e-0373803PS50021
DomainEPHD

KMT2A PHF14

3.96e-0322802PS51805
DomainCH-domain

MICAL2 MICAL3 VAV2

4.09e-0375803IPR001715
DomainGrowth_fac_rcpt_

FBN1 FBN2 SVEP1 NPNT

4.53e-03156804IPR009030
DomainJmjC

PHF2 PHF8

4.70e-0324802PF02373
DomaincEGF

FBN1 FBN2

5.51e-0326802IPR026823
DomaincEGF

FBN1 FBN2

5.51e-0326802PF12662
DomainhEGF

FBN2 SVEP1

6.37e-0328802PF12661
DomainJMJC

PHF2 PHF8

8.27e-0332802PS51184
DomainJmjC_dom

PHF2 PHF8

8.27e-0332802IPR003347
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH2 DCTN4 DNAH9

6.27e-0627644M47755
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

NCBP2 ZNF573 CDC16 ZNF347 KMT2A ZNF616 ZNF264 ZNF215 ZNF749 EZH2 ZNF416 ZNF548 ZNF529 RXRA ZNF354C RXRB CNOT4 ZNF710 ZNF77

7.50e-0613876419M734
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH2 DCTN4 DNAH9

4.17e-0543644M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH17 DNAH2 DCTN4 DNAH9

5.01e-0545644M47670
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE

RXRA RXRB

2.01e-045642M29791
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE

RXRA RXRB

2.01e-045642M29792
PathwayKEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION

RXRA RXRB

2.01e-045642M49023
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_GLUCONEOGENESIS

RXRA RXRB

2.01e-045642M29812
PathwayWP_VITAMIN_A1_AND_A5X_PATHWAYS

RXRA RXRB

3.01e-046642M48097
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

RXRA RXRB

3.01e-046642MM15663
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF780A ZNF347 KMT2A ZNF616 EZH2 ZNF416 RXRA ZNF354C RXRB CNOT4 ZNF710

6.14e-047686411MM14851
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS

RXRA RXRB

7.16e-049642M29789
PathwayKEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY

RXRA RXRB

7.16e-049642M47629
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

RXRA RXRB

7.16e-049642M29809
PathwayWP_VITAMIN_D_METABOLISM

RXRA RXRB

8.92e-0410642M39352
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF462 PHF2 PPP1R10 ZNF384 ATRX ZNF780A KMT2A PHF14 ZNF362 PHF8 EZH2 CHAMP1 CASZ1 ZMYM4

1.34e-10608811436089195
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF462 PHF2 PPP1R10 ZMAT5 ZNF326 TRPS1 ZNF347 ZNF616 PHF14 PHF8 ZNF236 RXRA ZNF354C RXRB ZNF710

5.35e-10808811520412781
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF462 PHF2 TUT4 ATP2C1 ATRX MICAL2 TRPS1 PHF14 MICAL3 PLCB4 ZNF362 ZNF236 RXRA CASZ1 VAV2 ZMYM4 STT3A

4.75e-081489811728611215
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZNF462 PHF2 ATP2C1 THSD7A DNAH17 ZNF347 ZNF616 PHF14 MICAL3 CASZ1

2.29e-07493811015368895
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH17 DNAH2 DNAH9

4.23e-07781331178125
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN1 FBN2 THSD7A ZNF77 SPINK5

6.98e-077181533541421
Pubmed

Human transcription factor protein interaction networks.

ZNF462 PHF2 ZNF326 FBN1 FBN2 PPP6C ATRX TRPS1 COP1 KMT2A PHF8 GARRE1 RXRA ZMYM4 STT3A

9.48e-071429811535140242
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

PHF2 KMT2A PHF8 EZH2

1.06e-063381426864203
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

ZNF462 NCBP2 PPP1R10 PPP6C ATRX KMT2A PHF14 EZH2 ZMYM4

1.51e-0646981927634302
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ZNF462 PPP1R10 ZNF384 ATP2C1 FBN2 PDLIM7 MICAL2 CTSC ZNF362 CHAMP1 CASZ1 ZMYM4 STT3A

4.02e-061203811329180619
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF780A ZNF264 ZNF749 ZNF841 ZNF529 ZNF77

4.29e-0618181637372979
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

ZNF462 KMT2A PHF14 CHAMP1 ZMYM4

4.43e-0610381532744500
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

PHF2 KMT2A PHF8 EZH2

5.34e-064981434368113
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

5.36e-06281212399449
Pubmed

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

RXRA RXRB

5.36e-0628127926783
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

5.36e-06281221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

5.36e-06281212429739
Pubmed

ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma.

ATRX EZH2

5.36e-06281232194873
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

5.36e-06281230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

5.36e-06281221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

5.36e-06281215131124
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

5.36e-06281212524050
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

5.36e-06281220404337
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

5.36e-0628128791520
Pubmed

Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.

RXRA RXRB

5.36e-06281224810760
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

5.36e-0628128120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

5.36e-06281235419902
Pubmed

Limited degradation of retinoid X receptor by calpain.

RXRA RXRB

5.36e-0628128780715
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

5.36e-0628128307578
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

5.36e-06281210504303
Pubmed

Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.

RXRA RXRB

5.36e-06281220798333
Pubmed

Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.

RXRA RXRB

5.36e-06281222316320
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

5.36e-0628127744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

5.36e-06281226408953
Pubmed

Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm.

FBN1 EZH2

5.36e-06281229515022
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

5.36e-06281218006876
Pubmed

Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.

RXRA RXRB

5.36e-06281233246082
Pubmed

Endogenous retinoid X receptor ligands in mouse hematopoietic cells.

RXRA RXRB

5.36e-06281229089448
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

5.36e-06281224833718
Pubmed

Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis guttata.

RXRA RXRB

5.36e-06281217341859
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

5.36e-06281224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

5.36e-06281220529844
Pubmed

Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.

ATRX EZH2

5.36e-0628129499421
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

5.36e-06281225524144
Pubmed

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

RXRA RXRB

5.36e-06281216199515
Pubmed

MLL1:EZH2 Ratio in Uterine Secretions and Endometrial Receptivity in Patients with Endometriosis.

KMT2A EZH2

5.36e-06281236094360
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

5.36e-06281223133647
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

5.36e-06281216407178
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

5.36e-0628121852206
Pubmed

A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.

RXRA RXRB

5.36e-06281219255444
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

5.36e-06281210359653
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZNF462 ZMAT5 ZNF326 ZNF780A TRPS1 KMT2A PHF14 CHAMP1 RXRA RXRB

5.94e-06709811022988430
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NCBP2 PHF2 PPP1R10 ZNF326 ATRX PCNX3 PDLIM7 CDC16 TRPS1 KMT2A PHF14 EZH2 CASZ1 ZMYM4

8.61e-061497811431527615
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NCBP2 PHF2 PPP1R10 ZNF326 ATRX CDC16 KMT2A PHF14 PHF8 EZH2 CHAMP1 CASZ1 ZMYM4

8.81e-061294811330804502
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

FBN1 FBN2 ADAMTS6

9.68e-061881335503090
Pubmed

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

ZNF462 TRPS1 ZNF362 CHAMP1 ZMYM4

1.14e-0512581532891193
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

ZNF462 ZNF326 ATRX CHAMP1 CASZ1 ZMYM4

1.31e-0522081635785414
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

PPP1R10 ZNF384 TRPS1 KMT2A PHF8 EZH2 CHAMP1

1.53e-0534181732971831
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

1.60e-05381210825173
Pubmed

Unique response pathways are established by allosteric interactions among nuclear hormone receptors.

RXRA RXRB

1.60e-0538127758108
Pubmed

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

RXRA RXRB

1.60e-0538129727070
Pubmed

PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.

PHF2 PHF8

1.60e-05381225204660
Pubmed

Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.

RXRA RXRB

1.60e-0538127831303
Pubmed

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.

RXRA RXRB

1.60e-05381219188585
Pubmed

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.

RXRA RXRB

1.60e-0538127990953
Pubmed

Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1.

RXRA RXRB

1.60e-05381227184385
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

1.60e-05381230201140
Pubmed

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

RXRA RXRB

1.60e-0538121312497
Pubmed

Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.

RXRA RXRB

1.60e-05381219897601
Pubmed

Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.

RXRA RXRB

1.60e-05381218375961
Pubmed

Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.

RXRA RXRB

1.60e-0538127980510
Pubmed

Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.

RXRA RXRB

1.60e-05381210049761
Pubmed

Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.

RXRA RXRB

1.60e-05381212514092
Pubmed

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.

RXRA RXRB

1.60e-05381211053444
Pubmed

Retinoid X receptors: X-ploring their (patho)physiological functions.

RXRA RXRB

1.60e-05381215608692
Pubmed

Chromosomal localization of the human retinoid X receptors.

RXRA RXRB

1.60e-0538128034312
Pubmed

Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.

KMT2A EZH2

1.60e-05381226431491
Pubmed

Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains.

RXRA RXRB

1.60e-0538128631847
Pubmed

Retinoid receptors trigger neuritogenesis in retinal degenerations.

RXRA RXRB

1.60e-05381221940995
Pubmed

The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.

RXRA RXRB

1.60e-05381211839661
Pubmed

Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.

RXRA RXRB

1.60e-05381218217139
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

1.60e-05381220855508
Pubmed

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

RXRA RXRB

1.60e-0538128799145
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

NCBP2 ZNF326 FBN2 PCNX3 CDC16 CTSC LRRK2 MICAL3 ZNF841 EZH2 CHAMP1 RXRA

2.40e-051215811215146197
Pubmed

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.

KMT2A EZH2

3.20e-05481229754954
Pubmed

Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.

RXRA RXRB

3.20e-0548128670810
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

3.20e-05481212429738
Pubmed

Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

KMT2A EZH2

3.20e-05481222396593
Pubmed

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.

RXRA RXRB

3.20e-0548121310259
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

3.20e-05481225406291
Pubmed

Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.

RXRA RXRB

3.20e-05481210079186
Pubmed

Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.

RXRA RXRB

3.20e-0548128524212
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

3.20e-05481220729550
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2

3.20e-05481225034023
Pubmed

Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.

RXRA RXRB

3.20e-05481226355550
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

3.20e-05481216835936
Pubmed

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.

RXRA RXRB

3.20e-05481219686701
Pubmed

Retinoid X receptors are essential for early mouse development and placentogenesis.

RXRA RXRB

3.20e-0548129892670
Pubmed

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

RXRA RXRB

3.20e-0548129348290
Pubmed

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

RXRA RXRB

3.20e-05481225574839
InteractionH3C3 interactions

ZNF462 PHF2 ZNF384 ATRX ZNF780A KMT2A PHF14 ZNF362 PHF8 EZH2 CHAMP1 ZMYM4

4.86e-074957912int:H3C3
InteractionH3-3A interactions

PHF2 PPP1R10 ZNF384 ATRX ZNF780A LRRK2 KMT2A PHF14 ZNF362 PHF8 EZH2 CHAMP1 CASZ1 ZMYM4

1.13e-067497914int:H3-3A
InteractionASF1A interactions

PHF2 ZNF384 ATRX TRPS1 KMT2A PHF14 ZNF362 CASZ1

5.94e-06249798int:ASF1A
InteractionTRIM28 interactions

ZNF462 ZNF326 ZNF573 PPP6C ATRX ZNF780A ZNF616 ZNF264 ZNF749 ZNF841 DCTN4 EZH2 CHAMP1 ZNF416 ZNF529 ZNF354C ZMYM4 ZNF77

1.21e-0514747918int:TRIM28
InteractionCENPA interactions

ZNF462 PHF2 ZNF384 ATRX KMT2A PHF14 ZNF362 PHF8 CASZ1

1.66e-05377799int:CENPA
InteractionMEN1 interactions

ZNF462 PPP1R10 ZNF384 ZNF326 ATRX CDC16 TRPS1 KMT2A DCTN4 PHF8 EZH2 CHAMP1 ZMYM4 STT3A

4.17e-0510297914int:MEN1
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF573 ZNF780A ZNF347 ZNF616 ZNF264 ZNF749 ZNF841 ZNF416 ZNF548 GARRE1 ZNF529

7.96e-0611928111chr19q13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF462 ZNF384 ZNF326 ZNF573 ZFAT ZNF780A TRPS1 ZNF347 ZNF616 ZNF264 ZNF215 ZNF749 ZNF362 ZNF841 ZNF236 CHAMP1 ZNF416 ZNF548 ZNF529 ZNF354C CASZ1 ZNF710 ZNF77

1.30e-15718702328
GeneFamilyDyneins, axonemal

DNAH17 DNAH2 DNAH9

3.64e-0517703536
GeneFamilyPHD finger proteins

PHF2 KMT2A PHF14 PHF8

4.10e-049070488
GeneFamilyLIM domain containing

PDLIM7 MICAL2 MICAL3

1.55e-03597031218
GeneFamilyPHD finger proteins|Lysine demethylases

PHF2 PHF8

3.86e-0324702485
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

ZNF462 TUT4 THSD7A ATRX ASIC2 LRRK2 DLG2 ZNF264 MICAL3 PLCB4 FRMPD3 GABBR2 VPS53 CASZ1 VAV2 NPNT ZNF77 CEMIP

5.77e-0911068118M39071
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

TUT4 ATP2C1 ATRX MICAL2 CDC16 PHF14 MICAL3 PLCB4 PHF8 GARRE1 CNOT4 ZMYM4 CEMIP

2.12e-068568113M4500
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

C17orf75 TUT4 ATRX ADAMTS6 ZNF616 PHF14 MICAL3 DCTN4 VPS53 GDF11 CNOT4 ZMYM4

2.96e-057807912Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#3

ZNF462 USP51 DNAH2 ZNF616 PHF14 EZH2 GDF11

6.76e-05271797Facebase_RNAseq_e10.5_Mandibular Arch_1000_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5

USP51 DNAH2 ZNF616 PHF14 EZH2 GDF11

6.82e-05186796Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500

ZNF462 TUT4 USP51 TRPS1 DNAH2 ZNF616 PHF14 EZH2 GDF11

8.74e-05492799Facebase_RNAseq_e10.5_Mandibular Arch_500
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF326 CDC16 CTSC LRRK2 RXRB BBS10

6.38e-07168816d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 ADAMTS6 TRPS1 PLCB4 NPNT

1.19e-061878165258674d0346e5c51a4b965efcdc1790c970845d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FBN1 MICAL3 VAV2 SVEP1 NPNT CEMIP

1.48e-0619481635f132cc38ac133be01834ed0946188aa0757eb4
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 DOCK11 CTSC DNAH17 LRRK2 NPNT

1.48e-061948168ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ZFAT HPR DNAH2 MUC5B DNAH9 SPINK5

1.71e-0619981660919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCellLPS_anti-TNF-Epithelial_airway|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ZFAT HPR DNAH2 MUC5B DNAH9 SPINK5

1.71e-061998166aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ZFAT HPR DNAH2 MUC5B DNAH9 SPINK5

1.76e-06200816cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

HPR DNAH2 MUC5B SLC9C2 DNAH9 SPINK5

1.76e-06200816da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ZFAT HPR DNAH2 MUC5B DNAH9 SPINK5

1.76e-06200816a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

HPR DNAH2 MUC5B SLC9C2 DNAH9 SPINK5

1.76e-0620081672c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 DOCK11 LRRK2 DLG2 NPNT

8.86e-06153815d6526d17826470534b766df144c74e73eb83fdad
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A TRPS1 CASZ1 NPNT CEMIP

1.24e-05164815f0499e6c1b17c4df72b18b294e3b53ef723da2ac
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C17orf75 ZNF573 ZNF780A DOCK11 ZNF416

1.60e-0517381579d11f94a8f6a420c18c2fef0da77e9af3204765
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FBN2 DOCK11 DNAH17 LRRK2

1.74e-05176815327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP51 ADAMTS6 ZNF362 CHAMP1 CASZ1

1.79e-05177815b8de0fc92691a6d6759c743195b11edd2d63f265
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|368C / Donor, Lineage, Cell class and subclass (all cells)

PHF2 PPP6C PHF8 ZNF236 ZNF354C

1.94e-05180815551b8de8d933d11bcd3897aeb2fd033355f958e2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A ASIC2 DLG2 CASZ1 VAV2

1.99e-05181815aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 DOCK11 LRRK2 DLG2 NPNT

1.99e-051818156956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FBN2 DOCK11 LRRK2 NPNT

2.05e-051828155e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ZNF462 CTSC TRPS1 PLCB4 CEMIP

2.05e-051828157b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A DLG2 DNAH9 CASZ1 NPNT

2.10e-051838153c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A DLG2 DNAH9 CASZ1 NPNT

2.10e-051838159c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF462 THSD7A LRRK2 NPNT CEMIP

2.16e-05184815658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TRPS1 PLCB4 NPNT

2.21e-051858157dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FBN1 ADAMTS6 TRPS1 PLCB4 NPNT

2.21e-051858159f19f04fc4d97dfc2dd78cde77b515f1cb5d51ec
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FBN2 DOCK11 LRRK2 NPNT

2.27e-051868155c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 DOCK11 LRRK2 DLG2 MICAL3

2.33e-051878159d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 THSD7A ADAMTS6 PLCB4 GARRE1

2.45e-05189815b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

ZFAT USP51 ZNF362 ZNF548 NPNT

2.58e-05191815c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A ADAMTS6 DOCK11 FRMPD3 VAV2

2.65e-05192815bf1943715085c4124b1675888b0615c9500ec888
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 PDLIM7 MICAL2 SVEP1 CEMIP

2.71e-05193815dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 PDLIM7 MICAL2 SVEP1 CEMIP

2.71e-05193815e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MICAL2 LRRK2 DLG2 CASZ1 NPNT

2.78e-0519481597534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_ACKR1+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FBN1 DOCK11 CTSC PLCB4 SPINK5

2.99e-05197815143607d195c8aa2b94d995af0b2ef38582565611
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Airway-Club|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ZFAT HPR DNAH2 MUC5B SPINK5

3.07e-051988156712216c5a7fd86b68fd45b0ff7794975f19774e
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

ZNF462 TUT4 ATRX KMT2A PHF14

3.07e-05198815de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TUT4 ATRX KMT2A PLCB4 GARRE1

3.22e-05200815dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

FBN2 THSD7A DOCK11 DNAH17 VAV2

3.22e-05200815f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

FBN2 THSD7A ADAMTS6 DOCK11 VAV2

3.22e-052008159ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

FBN2 THSD7A DOCK11 DNAH17 VAV2

3.22e-0520081570a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBN1 THSD7A ADAMTS6 PLCB4 GARRE1

3.22e-0520081577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

FBN1 THSD7A ADAMTS6 PLCB4 GARRE1

3.22e-0520081565b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FBN1 THSD7A ADAMTS6 PLCB4 GARRE1

3.22e-05200815ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

FBN2 THSD7A DOCK11 DNAH17 VAV2

3.22e-052008151639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBN1 THSD7A ADAMTS6 PLCB4 GARRE1

3.22e-05200815b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 LRRK2 MUC5B CASZ1

1.08e-041358148521107817df49efd9a2e81078c8535ed33e729c
ToppCelllung-Type_II_Pneumocytes|lung / shred on tissue and cell subclass

MICAL2 CTSC LRRK2 NPNT

1.50e-041478148a3039de45b8087f8319e2e37329acf7278219b7
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF462 FBN2 ADAMTS6 NPNT

1.97e-041588146d2709b387945c015faa223c20d22b52a4082140
ToppCellASK440-Immune-B_cell|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

TUT4 ZFAT DTWD1 ZNF215

2.02e-04159814d31eb59c1b5948df721b829b9a7e806f27cbd41c
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MUC5B DNAH9 SVEP1

2.07e-04160814c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

ADAMTS6 PDLIM7 MICAL3 PLCB4

2.07e-04160814d783d29150033e9181c0e30870070268fed3fd85
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 MUC5B DNAH9 SVEP1

2.07e-0416081425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH2 MUC5B DNAH9 SPINK5

2.28e-04164814e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THSD7A CASZ1 NPNT CEMIP

2.38e-04166814b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 CTSC SVEP1

2.55e-04169814c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DTWD1 DOCK11 DNAH17 LRRK2

2.61e-041708145d5f208682be21ed58320f5fc083a7898f8712da
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A CTSC TRPS1 NPNT

2.79e-0417381461907116a1460bc157ba73b5edd108db7dd5de4b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A CTSC TRPS1 NPNT

2.79e-04173814d17e50dc400098374af626803dec1241ec566769
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF384 DOCK11 LRRK2 CASZ1

2.91e-04175814cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 FBN2 DOCK11 LRRK2

2.91e-04175814284fdc7a9d303636a637041846850d19d114861a
ToppCellpdx-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

TUT4 ADAMTS6 VAV2 ZNF710

2.98e-041768141e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A CTSC TRPS1 NPNT

2.98e-041768144843af68f013732c28a8b8edad30d5fa0f2b084b
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 THSD7A GABBR2 SVEP1

2.98e-04176814fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A CTSC TRPS1 NPNT

2.98e-0417681495d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 THSD7A GABBR2 SVEP1

2.98e-04176814f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRRK2 DLG2 SVEP1 NPNT

3.04e-04177814b7fee75de7e96924af488a5baa2334711889ae7c
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THSD7A ADAMTS6 PLCB4 MAP3K6

3.04e-041778145ff8dcfb030312126695d53a026d2e104a401b83
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 PDLIM7 TRPS1 NPNT

3.04e-04177814e65c0568dc5852108e9802273499bc7cf88fafab
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 MICAL2 ZNF841 SVEP1

3.04e-04177814b872ee91e01265b101b81bd304cf6b95d5419e68
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R10 ATRX PLCB4 CNOT4

3.11e-0417881401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS6 PDLIM7 HPR GARRE1

3.11e-04178814e2363810d77b6b245394a666eb51bacd345c43f7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A CTSC TRPS1 NPNT

3.17e-041798143b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 THSD7A ADAMTS6 PLCB4

3.17e-041798141ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS6 DNAH2 FRMPD3 SVEP1

3.17e-041798140b6731d9554f8bed1899c165a50e6b329ea19a6d
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CTSC TRPS1 DLG2 PLCB4

3.17e-0417981414fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 TRPS1 PLCB4 VAV2

3.24e-04180814e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBN2 THSD7A DOCK11 VAV2

3.31e-0418181435bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A DOCK11 LRRK2 PLCB4

3.31e-041818149d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 TRPS1 PLCB4 VAV2

3.38e-0418281472e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 TRPS1 PLCB4 VAV2

3.38e-0418281405c167158815bf25d509df59ab386e1990712765
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBN2 DOCK11 DNAH17 LRRK2

3.45e-0418381492fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 THSD7A MICAL2 PLCB4

3.45e-04183814351d575339038bd4a66f408da518c567444208e8
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN2 ADAMTS6 PDLIM7 NPNT

3.45e-04183814af8d86f15a549064530d94bd47081daf59d58ecd
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

DOCK11 DLG2 ZNF354C SVEP1

3.52e-0418481467164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R10 TUT4 ATRX KMT2A

3.52e-041848141154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MICAL2 CTSC LRRK2 NPNT

3.52e-04184814ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD7A DLG2 CASZ1 NPNT

3.52e-041848147294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

FBN1 FBN2 ADAMTS6 PDLIM7

3.60e-04185814427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A ADAMTS6 FRMPD3 SVEP1

3.60e-04185814cefd81adb480c027545a5c78dcd05669783717f4
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

FBN1 DLG2 SVEP1 CEMIP

3.60e-04185814a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellMild-Lymphoid-pDC|Mild / Condition, Lineage, Cell class and cell subclass

ZFAT PLCB4 TLR9 SLC9C2

3.67e-041868147fa82972c726025d6402e5eb7bf0db3b699eba4c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TRPS1 PLCB4

3.67e-041868144d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCellBAL-Mild-Myeloid-pDC-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZFAT PLCB4 TLR9 SLC9C2

3.67e-04186814b031f4e6867b6200b85f43276a34749bf5f4603f
ToppCellBAL-Mild-Myeloid-pDC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ZFAT PLCB4 TLR9 SLC9C2

3.67e-04186814d2fbf53aac905c9896272ec5c2db28ee1a60f4be
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 DOCK11 LRRK2 MICAL3

3.67e-04186814f28d72b47624b69a580b4429e2be560a26898591
ToppCellMild-Lymphoid-pDC-|Mild / Condition, Lineage, Cell class and cell subclass

ZFAT PLCB4 TLR9 SLC9C2

3.67e-041868141d05e73ae2ec0cc27f79e4fa40d6b21790059f80
ToppCellBAL-Mild-Myeloid-pDC-pDC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZFAT PLCB4 TLR9 SLC9C2

3.67e-0418681479aedd5aed72509a4925e9f6cb43bc0c798c86f5
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MICAL2 CTSC LRRK2 NPNT

3.67e-04186814e83718fabb057100835d3357df407f283d23fe16
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FBN1 ADAMTS6 TRPS1 PLCB4

3.75e-0418781413731298bc562ec29582f5da1b4c97261284f6f1
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAMTS6 CTSC EZH2 CASZ1

3.75e-04187814d17352f769c3c66601b65d060626eecff41b0482
ComputationalNeighborhood of GSPT1

PHF2 ZNF384 ATP2C1 KMT2A DCTN4 VPS53 ZNF529

8.97e-06169487GCM_GSPT1
ComputationalNeighborhood of RBM8A

PHF2 ZNF384 KMT2A DCTN4 ZNF529

2.85e-0581485GCM_RBM8A
ComputationalNeighborhood of MLL

PHF2 ZNF384 KMT2A CHAMP1 VPS53 ZNF529

1.15e-04174486GCM_MLL
ComputationalNeighborhood of NCAM1

ZNF462 PHF2 DCTN4 GABBR2 ZNF529

2.43e-04127485GCM_NCAM1
ComputationalNeighborhood of SUFU

PHF2 KMT2A DCTN4 ZNF529

3.73e-0477484GCM_SUFU
ComputationalNeighborhood of UBE2N

PHF2 ZNF384 KMT2A DCTN4 ZNF529

5.89e-04154485GCM_UBE2N
ComputationalNeighborhood of MYST2

ZNF462 PHF2 ZNF384 DCTN4 ZNF529

9.71e-04172485GCM_MYST2
DrugNomifensine maleate [32795-47-4]; Up 200; 11.2uM; PC3; HT_HG-U133A

ZMAT5 DTWD1 PDLIM7 PHF8 DNAH9 ZNF710 CEMIP

6.39e-061968175863_UP
DrugVitamin K2 [11032-49-8]; Down 200; 9uM; PC3; HT_HG-U133A

PDLIM7 MICAL2 KMT2A ZNF749 GABBR2 CNOT4 CEMIP

6.61e-061978173798_DN
Drug(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; HL60; HT_HG-U133A

FBN1 PDLIM7 DNAH17 PHF8 GABBR2 CASZ1 ZNF710

6.83e-061988173067_UP
DrugBemegride [64-65-3]; Down 200; 25.8uM; HL60; HT_HG-U133A

ATP2C1 PDLIM7 TRPS1 TTLL1 ZNF215 GABBR2 ZNF710

6.83e-061988173051_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

PHF2 DTWD1 TRPS1 ZNF236 RXRA ZNF710

2.83e-051668167324_DN
DrugBexarotene

RXRA RXRB

3.74e-053812DB00307
Drug2-hydroxyphytanic acid

RXRA RXRB

3.74e-053812ctd:C002585
DrugAC1O5SBP

RXRA RXRB

3.74e-053812CID006439746
DrugProstaglandin E1; Down 200; 10uM; PC3; HT_HG-U133A

ZNF573 ATRX PDLIM7 MICAL2 GARRE1 RXRA

6.76e-051948166555_DN
DrugCarbachol [51-83-2]; Up 200; 21.8uM; MCF7; HT_HG-U133A

ZNF236 VPS53 CASZ1 VAV2 SPINK5 CEMIP

6.76e-051948165342_UP
DrugClozapine [5786-21-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A

ZMAT5 ZNF573 PDLIM7 PHF8 GABBR2 CNOT4

6.76e-051948165630_DN
DrugNitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; MCF7; HT_HG-U133A

FBN1 PDLIM7 ZNF362 CNOT4 VAV2 ZNF710

6.96e-051958164705_UP
DrugSulindac [38194-50-2]; Down 200; 11.2uM; PC3; HT_HG-U133A

PDLIM7 TTLL1 PHF8 GABBR2 VPS53 GARRE1

6.96e-051958165103_DN
DrugProcarbazine hydrochloride [366-70-1]; Down 200; 15.6uM; HL60; HT_HG-U133A

DNAH17 KMT2A TTLL1 ZNF215 PLCB4 CNOT4

6.96e-051958162971_DN
DrugButylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A

PDLIM7 VPS53 RXRA ZMYM4 ZNF710 SPINK5

6.96e-051958165245_DN
DrugEstropipate [7280-37-7]; Down 200; 9.2uM; HL60; HT_HG-U133A

ZMAT5 FBN2 PDLIM7 CDC16 PLCB4 BBS10

7.16e-051968162506_DN
DrugRo 15-0778

HPR RXRA RXRB

7.30e-0523813CID006436116
DrugLidoflazine [3416-26-0]; Up 200; 8.2uM; MCF7; HT_HG-U133A

FBN2 PDLIM7 MUC5B VPS53 VAV2 CEMIP

7.36e-051978163201_UP
DrugMimosine [500-44-7]; Up 200; 20.2uM; PC3; HT_HG-U133A

PDLIM7 MICAL2 KMT2A PHF14 GABBR2 VPS53

7.36e-051978166703_UP
DrugTerconazole [67915-31-5]; Down 200; 7.6uM; HL60; HT_HG-U133A

PHF2 FBN2 PDLIM7 MICAL3 ZNF215 VPS53

7.36e-051978162484_DN
DrugCefaclor [70356-03-5]; Up 200; 10.4uM; PC3; HT_HG-U133A

ZMAT5 ZNF573 KMT2A ZNF215 ZNF362 VAV2

7.36e-051978166622_UP
DrugAGN 190727

RXRA RXRB

7.47e-054812CID006439768
DrugDipyrone [5907-38-0]; Down 200; 12uM; PC3; HT_HG-U133A

ATRX PDLIM7 GABBR2 VPS53 RXRA CNOT4

7.57e-051988163754_DN
DrugRepaglinide [135062-02-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A

ZNF573 ATRX PDLIM7 MICAL2 MAP3K6 CASZ1

7.57e-051988167216_DN
DrugPiroxicam [36322-90-4]; Up 200; 12uM; HL60; HG-U133A

PHF2 ATP2C1 PITPNA EZH2 CASZ1 ZNF710

7.57e-051988161405_UP
DrugProxyphylline [603-00-9]; Down 200; 16.8uM; HL60; HT_HG-U133A

FBN2 PDLIM7 KMT2A ZNF215 VPS53 ZNF710

7.78e-051998163115_DN
DrugIobenguane sulfate; Up 200; 10.8uM; MCF7; HT_HG-U133A

TUT4 THSD7A TTLL1 ZNF236 GABBR2 SVEP1

8.00e-052008166002_UP
Drug7-methoxycitronellal

RXRA RXRB

1.24e-045812CID000019223
Drug7-methoxycitronellic acid

RXRA RXRB

1.24e-045812CID000171516
Drug13,14-dihydroretinol

RXRA RXRB

1.24e-045812CID000446798
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

1.96e-053762DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

3.92e-054762DOID:0060249 (is_implicated_in)
DiseaseWeaver syndrome

KMT2A EZH2

6.51e-055762C0265210
Diseasefactor VIII measurement, coagulation factor measurement

ASIC2 VAV2

6.51e-055762EFO_0004630, EFO_0004634
Diseaseresponse to bronchodilator, response to corticosteroid

ZNF616 ZNF841

6.51e-055762GO_0031960, GO_0097366
Diseaseacute lymphoblastic leukemia (implicated_via_orthology)

KMT2A EZH2

9.75e-056762DOID:9952 (implicated_via_orthology)
Diseasecentral corneal thickness

FBN1 FBN2 ADAMTS6 KMT2A RXRA VAV2

1.48e-04309766EFO_0005213
Diseasesyndromic X-linked intellectual disability (implicated_via_orthology)

PHF2 PHF8

1.81e-048762DOID:0060309 (implicated_via_orthology)
Diseasemyelofibrosis (is_implicated_in)

KMT2A EZH2

1.81e-048762DOID:4971 (is_implicated_in)
Diseasenon-alcoholic fatty liver disease, type 2 diabetes mellitus

DLG2 SLC9C2 VPS53 VAV2

1.91e-04110764EFO_0003095, MONDO_0005148
DiseaseAgents acting on the renin-angiotensin system use measurement

FBN2 CDC16 TRPS1 CASZ1 SVEP1 NPNT

2.30e-04335766EFO_0009931
Diseasevascular endothelial growth factor measurement

ZNF462 DNAH2 ZNF710

4.13e-0456763EFO_0004762
Diseasethyroxine measurement, triiodothyronine measurement

ZNF616 ZNF841

8.68e-0417762EFO_0005130, EFO_0008392
Diseasesinusitis (is_marker_for)

MUC5B TLR9

9.75e-0418762DOID:0050127 (is_marker_for)
Disease4-ethylphenylsulfate measurement

DTWD1 ADAMTS6

9.75e-0418762EFO_0021148
Diseaseinsomnia measurement

PHF2 PPP1R10 TRPS1 KMT2A DLG2 PHF14

9.98e-04443766EFO_0007876
Diseasesensorineural hearing loss (implicated_via_orthology)

DNAH17 DNAH9

1.09e-0319762DOID:10003 (implicated_via_orthology)
Diseasecorneal resistance factor

FBN1 FBN2 ADAMTS6 KMT2A RXRA VAV2

1.09e-03451766EFO_0010067
Diseasecardiovascular disease

FBN2 HPR DLG2 CASZ1 SVEP1 NPNT

1.17e-03457766EFO_0000319
DiseaseCraniosynostosis

ZNF462 EZH2

1.21e-0320762C0010278
Diseasefemale reproductive system disease

ASIC2 GABBR2

1.60e-0323762EFO_0009549
Diseasemean arterial pressure

FBN2 PCNX3 RXRA CASZ1 SVEP1 NPNT

1.83e-03499766EFO_0006340
Diseaseresponse to TNF antagonist, joint damage measurement

DLG2 GABBR2

1.89e-0325762EFO_0004653, EFO_0005413
Diseaseintraocular pressure measurement

FBN1 FBN2 THSD7A ADAMTS6 KMT2A RXRA

2.02e-03509766EFO_0004695
DiseaseAntiglaucoma preparations and miotics use measurement

THSD7A KMT2A

2.04e-0326762EFO_0009944
DiseaseCalcium channel blocker use measurement

FBN2 CASZ1 SVEP1 NPNT

2.26e-03213764EFO_0009930
DiseaseHematopoetic Myelodysplasia

ATRX EZH2

2.54e-0329762C2713368

Protein segments in the cluster

PeptideGeneStartEntry
YKCMECGKAYSYRSN

ZNF354C

496

Q86Y25
AYMTKCGHSFCYKCI

COP1

146

Q8NHY2
RENCGYKFCGRTHMY

CASZ1

1461

Q86V15
DYFFKCMTCKSGIGV

BBS10

196

Q8TAM1
ICSGCYAQMYIQAYK

CEMIP

996

Q8WUJ3
ICFMKGAYEQVIKYC

ATP2C1

476

P98194
LKFKFCSRAYFRQMC

ADAMTS6

1096

Q9UKP5
VFTKYGKCYMFNSGE

ASIC2

186

Q16515
GKFKMCFNYEIRVFC

MUC5B

2951

Q9HC84
GKFKMCFNYEIRVFC

MUC5B

3651

Q9HC84
DCPYMCAYKLVTVKF

PITPNA

186

Q00169
SDTCYFCQKRVYVME

MICAL3

761

Q7RTP6
MKKTACGFCFVEYYS

NCBP2

76

P52298
KHRCMNTYGSYKCYC

NPNT

101

Q6UXI9
DGKFYTNKCYMCRAV

SPINK5

941

Q9NQ38
FCVGMSKYQEDTCYG

HPR

281

P00739
DLYCMCGRIYKDMFF

MAP3K6

351

O95382
ADRRGKVYDKYMCSF

EZH2

651

Q15910
KYCFYCRALLMTVAG

PCNX3

1171

Q9H6A9
ADYGIAQYCCRMGIK

LRRK2

2016

Q5S007
ALFKCYMFLKNCGSG

C17orf75

346

Q9HAS0
PYCERDYEKMFGTKC

PDLIM7

386

Q9NR12
MNYSKYGAKECSFCE

PHF14

431

O94880
HYYNCDFKMCYKLTS

CDC16

241

Q13042
ICKNCFKYYMSDDIS

ATRX

196

P46100
FFKGRVNMCAAFCYE

DOCK11

1471

Q5JSL3
TYDFCCVNMKLFFKD

DNAH17

386

Q9UFH2
KNTMGSYRCLCKEGY

FBN1

1381

P35555
LRMSYCYAKFEGGKC

FBN1

2056

P35555
YMKRGKGKYYCKICC

CHAMP1

701

Q96JM3
SIRYCFYYRKCDMAD

FRMPD3

1526

Q5JV73
MYCCSAQDSKMDYKR

GARRE1

1

O15063
YKANYCSGQCEYMFM

GDF11

336

O95390
CKMKEDCFRYYSSEY

CTSC

331

P53634
AKVFCCAYEENMYGS

GABBR2

261

O75899
REKYYDSKGIGCYMF

KMT2A

3871

Q03164
MFFACYCALRTNVKK

DLG2

1

Q15700
CSEQMDYKSCGNIYK

DNAH9

1896

Q9NYC9
NCMDMRKSFCYRSYN

FBN2

1731

P35556
TTMKKAYYLACGFCR

DCTN4

101

Q9UJW0
RKKSAKGMYSCPCYY

DNAH2

4371

Q9P225
RCQYCRYQKCLAMGM

RXRA

186

P19793
SKCLKCGGSRMFYCY

DTWD1

56

Q8N5C7
TCYFCKKRVYVMERL

MICAL2

1001

O94851
HCSKYQQYKMSKYCE

PLCB4

411

Q15147
SEMFFADQVDKCYKC

PHF2

291

O75151
TKSCYDGQCYEYKWM

THSD7A

1466

Q9UPZ6
KMCYYRFGQVYTEAK

STT3A

641

P46977
AMVAYSCNKGFYIKG

SVEP1

2166

Q4LDE5
RCQYCRYQKCLATGM

RXRB

256

P28702
GCGTRYTVMAKNCYK

C10orf82

121

Q8WW14
GTTKYCSYFLKNMQC

CNOT4

191

O95628
KYFRCKFCNFTYMGN

TRPS1

331

Q9UHF7
GVIYCFMCKDYVYDK

USP51

281

Q70EK9
KTYRCRMCSLTFYSK

ZNF384

226

Q8TF68
ACKVCGKTFMYYSYL

ZNF77

241

Q15935
GKRAMKCPYCDFYFM

ZFAT

876

Q9P243
YQCDVCGKIFRKNSY

ZNF616

241

Q08AN1
YECNKCGKFFMYNSK

ZNF749

326

O43361
KTYECRQCGKAFIYA

ZNF573

216

Q86YE8
YCYRCGNIASIMVFK

PPP6C

261

O00743
FLFMDGNCYYKNPCR

TLR9

171

Q9NR96
QKMAKCAVQDYTYRG

SMRP1

61

Q8NCR6
QCRMCEKSYTSKYNL

ZNF710

296

Q8N1W2
VCKECGMAFRYHYQL

ZNF780A

306

O75290
CADLFVYYKKCMVQC

VPS53

471

Q5VIR6
YMCNECGKAFSVYSS

ZNF347

541

Q96SE7
NKCGMVFTYYSCLAR

ZNF841

456

Q6ZN19
CMECGKAFNRKSYLT

ZNF264

261

O43296
YVCGECGKAFMFKSK

ZNF416

466

Q9BWM5
MGKRYFCDYCDRSFQ

ZMAT5

1

Q9UDW3
MNSYECYQCGKAFCR

ZNF215

376

Q9UL58
RTYECRECGKSFMYN

ZNF548

251

Q8NEK5
KHAKAYCCSMCGRAY

ZNF362

366

Q5T0B9
LAMFTREDKYSCQYC

ZNF462

2016

Q96JM2
RPYKCAYCVMGFTQK

ZNF236

1776

Q9UL36
EMFFGDQVDKCYKCS

PHF8

326

Q9UPP1
GAAKCYYSIQGKFMS

SLC9C2

541

Q5TAH2
NCKACKMFLRGTFYQ

VAV2

536

P52735
PCKYMEYGNTCSFYK

ZNF529

226

Q6P280
QYLGYTMKVFAKRCD

TUT4

1096

Q5TAX3
MMKGNCRYENNCAFY

PPP1R10

916

Q96QC0
KMFQFCGKNCSDEYK

ZMYM4

706

Q5VZL5
YTVLFYQMAKCDACK

ZMYM4

806

Q5VZL5
CYMYKLGFCRFCTVK

TTLL1

211

O95922
DGYRMAFTCSFCKFR

ZNF326

306

Q5BKZ1