Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

HECTD4 BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 RNF133

6.53e-0647310412GO:0004842
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

CYP2C19 CYP2C8 CYP2C9

7.54e-0681043GO:0033695
GeneOntologyMolecularFunctioncaffeine oxidase activity

CYP2C19 CYP2C8 CYP2C9

7.54e-0681043GO:0034875
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

HECTD4 BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 RNF133

1.44e-0551210412GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

HECTD4 BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 RNF133

2.11e-0553210412GO:0016755
GeneOntologyMolecularFunctionestrogen 16-alpha-hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

2.20e-05111043GO:0101020
GeneOntologyMolecularFunction(R)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

2.69e-0521042GO:0052741
GeneOntologyMolecularFunction(S)-limonene 6-monooxygenase activity

CYP2C19 CYP2C9

2.69e-0521042GO:0018675
GeneOntologyMolecularFunction(S)-limonene 7-monooxygenase activity

CYP2C19 CYP2C9

2.69e-0521042GO:0018676
GeneOntologyMolecularFunctionlimonene monooxygenase activity

CYP2C19 CYP2C9

2.69e-0521042GO:0019113
GeneOntologyMolecularFunctionP-type manganese transporter activity

ATP2C1 ATP2C2

2.69e-0521042GO:0140613
GeneOntologyMolecularFunctionretinoic acid 4-hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

4.79e-05141043GO:0008401
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH or CH2 groups

CYP2C19 CYP2C8 CYP2C9

5.97e-05151043GO:0016725
GeneOntologyMolecularFunctionfolic acid receptor activity

FOLR1 FOLR3

8.03e-0531042GO:0061714
GeneOntologyMolecularFunctiontransition metal ion binding

ZNF93 CYP2C19 CYP2C8 CYP2C9 NT5E ZNF195 MDM4 TRIM22 TRIM5 ATP2C1 TRAFD1 BRCA1 SLFN13 MIB1 MTARC2 SLFN11 PLSCR2

1.33e-04118910417GO:0046914
GeneOntologyMolecularFunctionubiquitin protein ligase activity

BIRC3 TRIM22 TRIM5 RFPL4AL1 RFPL4A NEURL1 MIB1 CCAR1 RNF133

1.42e-043721049GO:0061630
GeneOntologyMolecularFunctionarachidonate 11,12-epoxygenase activity

CYP2C19 CYP2C9

1.60e-0441042GO:0008405
GeneOntologyMolecularFunctionlinoleic acid epoxygenase activity

CYP2C19 CYP2C9

1.60e-0441042GO:0071614
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

BIRC3 TRIM22 TRIM5 RFPL4AL1 RFPL4A NEURL1 MIB1 CCAR1 RNF133

2.35e-043981049GO:0061659
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2C19 CYP2C8 CYP2C9

2.57e-04241043GO:0008392
GeneOntologyMolecularFunctionfatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

2.66e-0451042GO:0120502
GeneOntologyMolecularFunctionlong-chain fatty acid omega-1 hydroxylase activity

CYP2C19 CYP2C9

2.66e-0451042GO:0120319
GeneOntologyMolecularFunctionarachidonate 14,15-epoxygenase activity

CYP2C19 CYP2C9

2.66e-0451042GO:0008404
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2C19 CYP2C8 CYP2C9

3.67e-04271043GO:0008391
GeneOntologyMolecularFunctionacyltransferase activity

HECTD4 BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 RNF133

7.04e-0477510412GO:0016746
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2C19 CYP2C8 CYP2C9

7.30e-04341043GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP2C19 CYP2C8 CYP2C9

7.96e-04351043GO:0070330
GeneOntologyMolecularFunctiontRNA binding

KARS1 SLFN13 MTRFR SLFN11

1.11e-03871044GO:0000049
GeneOntologyMolecularFunctionmanganese ion transmembrane transporter activity

ATP2C1 ATP2C2

1.18e-03101042GO:0005384
GeneOntologyMolecularFunctionP-type calcium transporter activity

ATP2C1 ATP2C2

1.43e-03111042GO:0005388
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2C19 CYP2C8 CYP2C9

2.12e-03491043GO:0016712
GeneOntologyMolecularFunctionenzyme activator activity

PSAP LRRK2 NBN CHM GRM5 TBC1D8 VPS9D1 ARHGAP5 NOD1 ARHGAP21

2.23e-0365610410GO:0008047
GeneOntologyMolecularFunctionzinc ion binding

ZNF93 NT5E ZNF195 MDM4 TRIM22 TRIM5 TRAFD1 BRCA1 SLFN13 MIB1 SLFN11 PLSCR2

2.30e-0389110412GO:0008270
GeneOntologyMolecularFunctionenzyme regulator activity

PSAP LRRK2 BIRC3 NBN BRCC3 WFDC10B CHM GRM5 TBC1D8 VPS9D1 ARHGAP5 GLMN WFDC3 NOD1 PRKAR1B ARHGAP21

2.67e-03141810416GO:0030234
GeneOntologyMolecularFunctionGTPase activator activity

LRRK2 CHM TBC1D8 VPS9D1 ARHGAP5 ARHGAP21

3.41e-032791046GO:0005096
GeneOntologyMolecularFunctionCARD domain binding

NOD1 CARD11

3.47e-03171042GO:0050700
GeneOntologyMolecularFunctionATP-dependent activity

ATP8B3 MYO1H MCM3 DICER1 ACSL3 ATP2C1 SLFN13 ATP2C2 SLFN11

4.77e-036141049GO:0140657
GeneOntologyMolecularFunctionfolic acid binding

FOLR1 FOLR3

4.80e-03201042GO:0005542
GeneOntologyBiologicalProcessregulation of viral entry into host cell

NBN TRIM22 TRIM5 RFPL4AL1 RFPL4A

8.03e-06551035GO:0046596
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

LRRK2 HECTD4 BIRC3 NBN BRCC3 USP37 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 USP48 RNF133

9.93e-06100910317GO:0070647
GeneOntologyBiologicalProcesspositive regulation of canonical NF-kappaB signal transduction

BIRC3 TRIM22 TRIM5 RFPL4AL1 RFPL4A NOD1 ATP2C1 CARD11

1.16e-052131038GO:0043123
GeneOntologyBiologicalProcessmodulation by symbiont of entry into host

NBN TRIM22 TRIM5 RFPL4AL1 RFPL4A

1.45e-05621035GO:0052372
GeneOntologyBiologicalProcesspost-translational protein modification

LRRK2 HECTD4 BIRC3 NBN BRCC3 USP37 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 USP48 RNF133

2.22e-05107410317GO:0043687
GeneOntologyBiologicalProcesspositive regulation of autophagy

LRRK2 DAPK1 TRIM22 TRIM5 RFPL4AL1 RFPL4A NOD1

2.60e-051731037GO:0010508
GeneOntologyBiologicalProcessregulation of biological process involved in symbiotic interaction

NBN TRIM22 TRIM5 RFPL4AL1 RFPL4A

3.68e-05751035GO:0043903
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP2C19 CYP2C8 CYP2C9

4.23e-05141033GO:0097267
GeneOntologyBiologicalProcessprotein ubiquitination

LRRK2 HECTD4 BIRC3 NBN MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 RNF133

5.05e-0581110314GO:0016567
GeneOntologyBiologicalProcesstRNA decay

DICER1 SLFN13 SLFN11

9.34e-05181033GO:0016078
GeneOntologyBiologicalProcesspositive regulation of NF-kappaB transcription factor activity

TRIM22 TRIM5 RFPL4AL1 RFPL4A NOD1 CARD11

1.11e-041511036GO:0051092
GeneOntologyBiologicalProcessregulation of canonical NF-kappaB signal transduction

BIRC3 TRIM22 TRIM5 RFPL4AL1 RFPL4A NOD1 ATP2C1 CARD11

1.25e-042981038GO:0043122
GeneOntologyBiologicalProcessregulation of viral life cycle

NBN TRIM22 DICER1 TRIM5 RFPL4AL1 RFPL4A

1.33e-041561036GO:1903900
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

LRRK2 HECTD4 BIRC3 NBN MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 CCAR1 RNF133

1.40e-0489310314GO:0032446
GeneOntologyBiologicalProcessperipheral nervous system myelin formation

ITGB4 DICER1

1.47e-0441032GO:0032290
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2C19 CYP2C8 CYP2C9

1.74e-04221033GO:0019373
GeneOntologyBiologicalProcessdefense response to symbiont

BIRC3 DAPK1 BRCC3 CD46 WFDC10B TRIM22 DICER1 TRIM5 RFPL4AL1 WFDC3 RFPL4A NOD1 TRAFD1 SLFN13 MICB SLFN11 SLAMF7

2.04e-04128610317GO:0140546
GeneOntologyBiologicalProcesssymbiont entry into host cell

NBN CD46 TRIM22 TRIM5 RFPL4AL1 RFPL4A

2.05e-041691036GO:0046718
GeneOntologyBiologicalProcesspositive regulation of Golgi to plasma membrane protein transport

ACSL3 ATP2C1

2.45e-0451032GO:0042998
GeneOntologyBiologicalProcesscanonical NF-kappaB signal transduction

BIRC3 TRIM22 TRIM5 RFPL4AL1 RFPL4A NOD1 ATP2C1 CARD11

2.51e-043301038GO:0007249
GeneOntologyBiologicalProcesssymbiont entry into host

NBN CD46 TRIM22 TRIM5 RFPL4AL1 RFPL4A

2.56e-041761036GO:0044409
GeneOntologyBiologicalProcesssperm-egg recognition

ATP8B3 FOLR1 FOLR3 GLIPR1L1

3.14e-04651034GO:0035036
GeneOntologyBiologicalProcesspositive regulation of DNA-binding transcription factor activity

TRIM22 TRIM5 RFPL4AL1 FZD4 RFPL4A NOD1 CARD11

3.38e-042611037GO:0051091
GeneOntologyBiologicalProcessregulation of viral process

NBN TRIM22 DICER1 TRIM5 RFPL4AL1 RFPL4A

3.44e-041861036GO:0050792
GeneOntologyBiologicalProcessplasma membrane organization

PSAP FOLR1 FOLR3 GLIPR1L1 PLSCR2 DNM2

3.64e-041881036GO:0007009
GeneOntologyBiologicalProcessmonoterpenoid metabolic process

CYP2C19 CYP2C9

3.66e-0461032GO:0016098
GeneOntologyBiologicalProcessdefense response to other organism

BIRC3 DAPK1 BRCC3 CD46 WFDC10B TRIM22 DICER1 TRIM5 RFPL4AL1 WFDC3 RFPL4A NOD1 TRAFD1 SLFN13 MICB SLFN11 SLAMF7

5.78e-04140710317GO:0098542
GeneOntologyBiologicalProcessfusion of sperm to egg plasma membrane involved in single fertilization

FOLR1 FOLR3 GLIPR1L1

5.92e-04331033GO:0007342
GeneOntologyBiologicalProcessprotein polyubiquitination

BIRC3 NBN TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1

6.21e-042891037GO:0000209
GeneOntologyBiologicalProcessprotein autoubiquitination

LRRK2 TRIM5 BRCA1 RNF133

6.30e-04781034GO:0051865
GeneOntologyBiologicalProcesssingle fertilization

ATP8B3 FOLR1 FOLR3 CD46 PKDREJ GLIPR1L1

6.37e-042091036GO:0007338
DomainZF_RING_2

BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 RNF133

5.86e-0629810310PS50089
DomainZnf_RING

BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 RNF133

1.28e-0532610310IPR001841
DomainP-type_ATPase_IIA_PMR1

ATP2C1 ATP2C2

3.01e-0521032IPR006413
DomainZF_RING_1

BIRC3 MDM4 TRIM22 TRIM5 RFPL4A BRCA1 NEURL1 MIB1 RNF133

3.34e-052911039PS00518
DomainRING

BIRC3 MDM4 TRIM22 TRIM5 RFPL4A BRCA1 NEURL1 MIB1 RNF133

4.81e-053051039SM00184
DomainDUF2075

SLFN13 SLFN11

9.00e-0531032PF09848
DomainDUF2075

SLFN13 SLFN11

9.00e-0531032IPR018647
DomainROC_dom

LRRK2 DAPK1

1.79e-0441032IPR020859
DomainROC

LRRK2 DAPK1

1.79e-0441032PS51424
DomainZnf_RING/FYVE/PHD

BIRC3 MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 RNF133

2.24e-0445910310IPR013083
DomainRDM_domain_RFPL

RFPL4AL1 RFPL4A

2.98e-0451032IPR022723
DomainRDM

RFPL4AL1 RFPL4A

2.98e-0451032PF11002
DomainFolate_rcpt

FOLR1 FOLR3

2.98e-0451032IPR004269
DomainCARD

BIRC3 NOD1 CARD11

4.83e-04281033PF00619
DomainARM-type_fold

PDS5B SMG1 SAAL1 LRRK2 RANBP6 HEATR5A PIK3C2G STAG3L3

5.78e-043391038IPR016024
DomainButyrophylin

TRIM22 TRIM5 RFPL4AL1 RFPL4A

6.05e-04701034IPR003879
DomainHEAT_REPEAT

PDS5B SMG1 RANBP6 HEATR5A

6.05e-04701034PS50077
DomainAlbA_2

SLFN13 SLFN11

6.21e-0471032PF04326
DomainSchlafen

SLFN13 SLFN11

6.21e-0471032IPR029684
DomainSchlafen_AAA_dom

SLFN13 SLFN11

6.21e-0471032IPR007421
DomainCARD

BIRC3 NOD1 CARD11

6.54e-04311033IPR001315
DomainARM-like

PDS5B SMG1 SAAL1 LRRK2 RANBP6 HEATR5A STAG3L3

7.43e-042701037IPR011989
DomainCARD

BIRC3 NOD1 CARD11

7.88e-04331033PS50209
DomainFolate_rec

FOLR1 FOLR3

8.25e-0481032PF03024
DomainFolate_rcpt-like

FOLR1 FOLR3

8.25e-0481032IPR018143
Domain-

MDM4 TRIM22 TRIM5 RFPL4AL1 RFPL4A BRCA1 NEURL1 MIB1 RNF133

8.45e-0444910393.30.40.10
DomainHAD-like_dom

ATP8B3 PHOSPHO2 ATP2C1 ATP2C2

9.54e-04791034IPR023214
DomainATPase_P-typ_P_site

ATP8B3 ATP2C1 ATP2C2

1.02e-03361033IPR018303
DomainP_typ_ATPase

ATP8B3 ATP2C1 ATP2C2

1.02e-03361033IPR001757
DomainATPASE_E1_E2

ATP8B3 ATP2C1 ATP2C2

1.02e-03361033PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B3 ATP2C1 ATP2C2

1.10e-03371033IPR008250
DomainE1-E2_ATPase

ATP8B3 ATP2C1 ATP2C2

1.10e-03371033PF00122
DomainNA-bd_OB-fold

MCM3 KARS1 CCAR1 PDCD11

1.15e-03831034IPR012340
DomainConA-like_dom

TRIM22 ITGB4 TRIM5 RFPL4AL1 RFPL4A USH2A

1.35e-032191036IPR013320
DomainSPRY

TRIM22 TRIM5 RFPL4AL1 RFPL4A

1.37e-03871034SM00449
Domain-

BIRC3 DAPK1 NOD1 CARD11

1.75e-039310341.10.533.10
DomainSPRY

TRIM22 TRIM5 RFPL4AL1 RFPL4A

1.82e-03941034PF00622
DomainSPRY_dom

TRIM22 TRIM5 RFPL4AL1 RFPL4A

1.82e-03941034IPR003877
DomainB30.2/SPRY

TRIM22 TRIM5 RFPL4AL1 RFPL4A

1.89e-03951034IPR001870
DomainB302_SPRY

TRIM22 TRIM5 RFPL4AL1 RFPL4A

1.89e-03951034PS50188
DomainCyt_P450_E_grp-I

CYP2C19 CYP2C8 CYP2C9

1.95e-03451033IPR002401
DomainDEATH-like_dom

BIRC3 DAPK1 NOD1 CARD11

2.20e-03991034IPR011029
DomainP-loop_NTPase

LRRK2 MCM3 DAPK1 DICER1 ARHGAP5 NOD1 SLFN13 CARD11 SLFN11 CHST2 DYNC1LI2 DNM2

2.44e-0384810312IPR027417
Domain-

LRRK2 MCM3 DICER1 ARHGAP5 NOD1 SLFN13 CARD11 SLFN11 CHST2 DYNC1LI2 DNM2

2.71e-03746103113.40.50.300
DomainPI3/4_kinase_CS

SMG1 PIK3C2G

3.02e-03151032IPR018936
DomainCyt_P450_CS

CYP2C19 CYP2C8 CYP2C9

3.12e-03531033IPR017972
DomainGRAM

TBC1D8 GRAMD2A

3.44e-03161032SM00568
Domain-

SMG1 PIK3C2G

3.44e-031610321.10.1070.11
DomainATPase_P-typ_TM_dom

ATP2C1 ATP2C2

3.44e-03161032IPR023298
DomainPI3Kc

SMG1 PIK3C2G

3.44e-03161032SM00146
Domain-

ATP2C1 ATP2C2

3.44e-031610321.20.1110.10
DomainCYTOCHROME_P450

CYP2C19 CYP2C8 CYP2C9

3.84e-03571033PS00086
DomainATPase_P-typ_cation-transptr_C

ATP2C1 ATP2C2

3.88e-03171032IPR006068
DomainCation_ATPase_C

ATP2C1 ATP2C2

3.88e-03171032PF00689
Domain-

WFDC10B WFDC3

3.88e-031710324.10.75.10
DomainWAP

WFDC10B WFDC3

3.88e-03171032PS51390
Domain-

CYP2C19 CYP2C8 CYP2C9

4.03e-035810331.10.630.10
Domainp450

CYP2C19 CYP2C8 CYP2C9

4.03e-03581033PF00067
DomainCation_ATPase_N

ATP2C1 ATP2C2

4.35e-03181032PF00690
DomainPI3_PI4_kinase

SMG1 PIK3C2G

4.35e-03181032PF00454
DomainPI3_4_KINASE_1

SMG1 PIK3C2G

4.35e-03181032PS00915
DomainPI3_4_KINASE_2

SMG1 PIK3C2G

4.35e-03181032PS00916
DomainPI3/4_kinase_cat_dom

SMG1 PIK3C2G

4.35e-03181032IPR000403
DomainCation_ATPase_N

ATP2C1 ATP2C2

4.35e-03181032SM00831
DomainPI3_4_KINASE_3

SMG1 PIK3C2G

4.35e-03181032PS50290
DomainCyt_P450

CYP2C19 CYP2C8 CYP2C9

4.44e-03601033IPR001128
DomainBRCT

NBN BRCA1

4.84e-03191032PF00533
DomainATPase_P-typ_cation-transptr_N

ATP2C1 ATP2C2

4.84e-03191032IPR004014
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C8 CYP2C9

7.02e-068723M27135
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP2C19 CYP2C8 CYP2C9

1.05e-059723M27143
PathwayREACTOME_CYP2E1_REACTIONS

CYP2C19 CYP2C8 CYP2C9

2.05e-0511723M27130
PathwayWP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID

CYP2C19 CYP2C8 CYP2C9

2.72e-0512723M48064
PathwayKEGG_MEDICUS_REFERENCE_DNA_END_RESECTION_AND_RPA_LOADING

NBN BRCC3 BRCA1

9.87e-0518723M47838
PathwayWP_TAMOXIFEN_METABOLISM

CYP2C19 CYP2C8 CYP2C9

1.59e-0421723M39631
PathwayREACTOME_XENOBIOTICS

CYP2C19 CYP2C8 CYP2C9

2.10e-0423723M5372
PathwayWP_ESTROGEN_METABOLISM_WP5276

CYP2C19 CYP2C8 CYP2C9

2.39e-0424723M46445
PathwayREACTOME_XENOBIOTICS

CYP2C19 CYP2C8 CYP2C9

2.71e-0425723MM14846
PathwayREACTOME_DEUBIQUITINATION

BIRC3 BRCC3 USP37 MDM4 NOD1 BRCA1 USP48

3.72e-04262727MM15286
PathwayREACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS

CYP2C8 CYP2C9

3.81e-046722M27909
PathwayKEGG_LINOLEIC_ACID_METABOLISM

CYP2C19 CYP2C8 CYP2C9

4.24e-0429723M2920
PathwayWP_CANNABINOID_RECEPTOR_SIGNALING

CYP2C19 CYP2C9 PRKAR1B

4.24e-0429723M39676
PathwayWP_ARACHIDONATE_EPOXYGENASE_EPOXIDE_HYDROLASE

CYP2C8 CYP2C9

5.31e-047722M39515
PathwayREACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET

CYP2C19 CYP2C8

5.31e-047722MM14856
PathwayREACTOME_BIOSYNTHESIS_OF_MARESINS

CYP2C8 CYP2C9

7.06e-048722M27891
PathwayREACTOME_DEUBIQUITINATION

BIRC3 BRCC3 USP37 MDM4 NOD1 BRCA1 USP48

8.16e-04299727M27574
Pubmed

CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108335134542
Pubmed

Distribution of CYP2C polymorphisms in an Amerindian population of Brazil.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108321977947
Pubmed

Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108323118231
Pubmed

Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108328687336
Pubmed

A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24.

CYP2C19 CYP2C8 CYP2C9

2.91e-08310838530044
Pubmed

Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108321173785
Pubmed

Genetic polymorphisms of CYP2C8, CYP2C9 and CYP2C19 in Ecuadorian Mestizo and Spaniard populations: a comparative study.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108324430292
Pubmed

Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108320665013
Pubmed

Genetic Polymorphisms and in Vitro Functional Characterization of CYP2C8, CYP2C9, and CYP2C19 Allelic Variants.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108327803446
Pubmed

Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population.

CYP2C19 CYP2C8 CYP2C9

2.91e-083108319954515
Pubmed

Biochemistry and molecular biology of the human CYP2C subfamily.

CYP2C19 CYP2C8 CYP2C9

1.16e-07410837704034
Pubmed

Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.

CYP2C19 CYP2C8 CYP2C9

1.16e-074108328990182
Pubmed

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

CYP2C19 CYP2C8 CYP2C9

1.16e-074108319706858
Pubmed

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

CYP2C19 CYP2C8 CYP2C9

1.16e-07410832009263
Pubmed

Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.

CYP2C19 CYP2C8 CYP2C9

1.16e-074108321798861
Pubmed

Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population.

CYP2C19 CYP2C8 CYP2C9

1.16e-074108316025294
Pubmed

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.

CYP2C19 CYP2C8 CYP2C9

1.16e-074108323755828
Pubmed

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

CYP2C19 CYP2C8 CYP2C9

2.90e-075108319415824
Pubmed

Prevalence of CYP450 gene variations in patients with type 2 diabetes.

CYP2C19 CYP2C8 CYP2C9

2.90e-075108320857895
Pubmed

STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.

STAG3L1 STAG3L2 STAG3L3

2.90e-075108310698974
Pubmed

Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population.

CYP2C19 CYP2C8 CYP2C9

5.78e-076108317635176
Pubmed

Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.

CYP2C19 CYP2C9 NBN BRCA1

7.44e-0723108416638864
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

CYP2C19 CYP2C8 CYP2C9

3.44e-0610108320602612
Pubmed

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.

CYP2C19 CYP2C8 CYP2C9

3.44e-0610108319651758
Pubmed

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.

CYP2C19 CYP2C8 CYP2C9

4.72e-0611108315469410
Pubmed

Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.

CYP2C19 CYP2C8 CYP2C9

4.72e-0611108315039299
Pubmed

BRCA1 tumor suppressor network: focusing on its tail.

NBN BRCC3 BRCA1

8.14e-0613108322369660
Pubmed

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.

CYP2C8 CYP2C9

9.55e-06210827574697
Pubmed

Individuals with CYP2C8 and CYP2C9 reduced metabolism haplotypes self-adjusted ibuprofen dose in the Coriell Personalized Medicine Collaborative.

CYP2C8 CYP2C9

9.55e-062108230562214
Pubmed

Effect of gender and CYP2C9 and CYP2C8 polymorphisms on the pharmacokinetics of ibuprofen enantiomers.

CYP2C8 CYP2C9

9.55e-062108226122864
Pubmed

Secretory pathway Ca2+ -ATPases promote in vitro microcalcifications in breast cancer cells.

ATP2C1 ATP2C2

9.55e-062108228618103
Pubmed

Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms.

CYP2C8 CYP2C9

9.55e-062108212435384
Pubmed

Important amino acid residues that confer CYP2C19 selective activity to CYP2C9.

CYP2C19 CYP2C9

9.55e-062108218511451
Pubmed

Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteers.

CYP2C8 CYP2C9

9.55e-062108218694831
Pubmed

Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients.

TRIM22 TRIM5

9.55e-062108227590274
Pubmed

Developmental expression of human hepatic CYP2C9 and CYP2C19.

CYP2C19 CYP2C9

9.55e-062108214634042
Pubmed

CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.

CYP2C19 CYP2C9

9.55e-062108210908295
Pubmed

Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.

CYP2C19 CYP2C9

9.55e-06210821847130
Pubmed

Restriction factors of retroviral replication: the example of Tripartite Motif (TRIM) protein 5 alpha and 22.

TRIM22 TRIM5

9.55e-062108219943174
Pubmed

The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.

CYP2C19 CYP2C8

9.55e-062108228513222
Pubmed

Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes.

CYP2C19 CYP2C9

9.55e-062108217599801
Pubmed

Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.

CYP2C19 CYP2C9

9.55e-062108215385837
Pubmed

[Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms].

CYP2C19 CYP2C9

9.55e-062108225518510
Pubmed

Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance.

CYP2C8 CYP2C9

9.55e-062108216372821
Pubmed

Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.

CYP2C19 CYP2C9

9.55e-062108215842554
Pubmed

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.

CYP2C19 CYP2C9

9.55e-062108219136640
Pubmed

Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.

CYP2C19 CYP2C9

9.55e-062108235748067
Pubmed

Linkage disequilibrium between the CYP2C19*17 and CYP2C8*2 alleles in populations of African descent.

CYP2C19 CYP2C8

9.55e-062108220890775
Pubmed

Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.

CYP2C19 CYP2C9

9.55e-062108232587777
Pubmed

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Iranian population.

CYP2C19 CYP2C9

9.55e-062108217201743
Pubmed

CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among children with nonlesional epilepsy: a single-center study.

CYP2C19 CYP2C9

9.55e-062108232683556
Pubmed

Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers.

CYP2C8 CYP2C9

9.55e-062108218548238
Pubmed

Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.

CYP2C19 CYP2C9

9.55e-062108215855721
Pubmed

The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects.

CYP2C19 CYP2C9

9.55e-062108219847408
Pubmed

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity.

CYP2C19 CYP2C9

9.55e-062108217504998
Pubmed

Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.

CYP2C19 CYP2C9

9.55e-062108224519941
Pubmed

Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.

CYP2C19 CYP2C9

9.55e-062108214623888
Pubmed

Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction.

CYP2C8 CYP2C9

9.55e-062108214646690
Pubmed

Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.

NBN BRCA1

9.55e-062108225939603
Pubmed

Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes.

CYP2C8 CYP2C9

9.55e-062108219480553
Pubmed

Rapid testing of clopidogrel resistance by genotyping of CYP2C19 and CYP2C9 polymorphisms using denaturing on-chip capillary electrophoresis.

CYP2C19 CYP2C9

9.55e-062108222589111
Pubmed

Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity.

BRCC3 BRCA1

9.55e-062108237887275
Pubmed

CYP2C9 and CYP2C19 genetic polymorphisms: frequencies in the south Indian population.

CYP2C19 CYP2C9

9.55e-062108215660966
Pubmed

Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy.

CYP2C19 CYP2C9

9.55e-062108218154472
Pubmed

Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.

CYP2C8 CYP2C9

9.55e-062108215766564
Pubmed

Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid-a large-scale study based on naturalistic therapeutic drug monitoring data.

CYP2C19 CYP2C9

9.55e-062108227353638
Pubmed

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects.

CYP2C19 CYP2C9

9.55e-062108217298483
Pubmed

Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study.

CYP2C19 CYP2C9

9.55e-062108233115391
Pubmed

Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort.

CYP2C8 CYP2C9

9.55e-062108221047199
Pubmed

Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting.

CYP2C19 CYP2C9

9.55e-062108217562299
Pubmed

Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals.

CYP2C8 CYP2C9

9.55e-062108216646575
Pubmed

Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant.

CYP2C19 CYP2C9

9.55e-062108236960518
Pubmed

Characterization of drug-metabolizing enzymes CYP2C9, CYP2C19 polymorphisms in Tunisian, Kuwaiti and Bahraini populations.

CYP2C19 CYP2C9

9.55e-062108226690534
Pubmed

cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.

CYP2C8 CYP2C9

9.55e-06210823697070
Pubmed

Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.

ATP2C1 ATP2C2

9.55e-062108216332677
Pubmed

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.

CYP2C19 CYP2C9

9.55e-062108219199010
Pubmed

Global variation in CYP2C8-CYP2C9 functional haplotypes.

CYP2C8 CYP2C9

9.55e-062108219381162
Pubmed

A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies.

CYP2C19 CYP2C9

9.55e-062108219358898
Pubmed

Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage.

CYP2C19 CYP2C9

9.55e-062108234438105
Pubmed

Chromosomal organization of the cytochrome P450-2C gene family in the mouse: a locus associated with constitutive aryl hydrocarbon hydroxylase.

CYP2C19 CYP2C9

9.55e-06210822895926
Pubmed

CYP2C8 and CYP2C9 polymorphisms in relation to tumour characteristics and early breast cancer related events among 652 breast cancer patients.

CYP2C8 CYP2C9

9.55e-062108219935798
Pubmed

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics and pharmacodynamics of gliclazide in healthy Chinese Han volunteers.

CYP2C19 CYP2C9

9.55e-062108220831536
Pubmed

CYP2C9, but not CYP2C19, polymorphisms affect the pharmacokinetics and pharmacodynamics of glyburide in Chinese subjects.

CYP2C19 CYP2C9

9.55e-062108216198656
Pubmed

Role of xenobiotic metabolism enzyme gene polymorphism in the formation of chemotherapy resistance in patients with chronic lymphoproliferative diseases.

CYP2C8 CYP2C9

9.55e-062108224288737
Pubmed

[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration].

CYP2C19 CYP2C9

9.55e-062108215569425
Pubmed

Death-associated protein kinase 1 variation and Parkinson's disease.

LRRK2 DAPK1

9.55e-062108221749573
Pubmed

Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes.

CYP2C19 CYP2C8

9.55e-062108222491019
Pubmed

Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.

CYP2C8 CYP2C9

9.55e-062108228686288
Pubmed

Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?

CYP2C8 CYP2C9

9.55e-062108220808793
Pubmed

The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

CYP2C8 CYP2C9

9.55e-062108215606441
Pubmed

An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug-resistant epilepsy in children.

CYP2C19 CYP2C9

9.55e-062108232567426
Pubmed

Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.

CYP2C19 CYP2C9

9.55e-062108217868191
Pubmed

Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.

CYP2C19 CYP2C9

9.55e-062108232868386
Pubmed

CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study.

CYP2C19 CYP2C9

9.55e-062108227617498
Pubmed

Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.

CYP2C19 CYP2C9

9.55e-062108216873909
Pubmed

Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.

CYP2C19 CYP2C9

9.55e-0621082106274
Pubmed

Genetic polymorphism of CYP2C9 and CYP2C19 in a Bolivian population: an investigative and comparative study.

CYP2C19 CYP2C9

9.55e-062108215776277
Pubmed

Effect of cytochrome P450 2C19 and 2C9 amino acid residues 72 and 241 on metabolism of tricyclic antidepressant drugs.

CYP2C19 CYP2C9

9.55e-062108224492587
Pubmed

Ovarian cancer patient with germline mutations in both BRCA1 and NBN genes.

NBN BRCA1

9.55e-062108218940477
Pubmed

Phase I pharmacokinetic and pharmacogenomic study of E7070 administered once every 21 days.

CYP2C19 CYP2C9

9.55e-062108216232205
InteractionZNF280D interactions

BIRC3 RLF BRCA1 ZNF292

6.82e-06241054int:ZNF280D
GeneFamilyRing finger proteins

BIRC3 TRIM22 TRIM5 RFPL4A BRCA1 NEURL1 RNF133

1.01e-0427571758
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

NBN BRCA1

1.51e-0457121336
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

BIRC3 NOD1 CARD11

2.18e-0430713959
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

BRCC3 BRCA1

2.26e-0467121328
GeneFamilySchlafen family

SLFN13 SLFN11

3.15e-0477121110
GeneFamilyCytochrome P450 family 2

CYP2C19 CYP2C8 CYP2C9

3.47e-04357131001
GeneFamilyATPases Ca2+ transporting

ATP2C1 ATP2C2

5.38e-0497121209
GeneFamilyWD repeat domain containing|GRAM domain containing|BEACH domain containing

TBC1D8 GRAMD2A

1.15e-03137121146
GeneFamilyWAP four-disulfide core domain containing|Fibronectin type III domain containing

WFDC10B WFDC3

2.23e-0318712361
CoexpressionHOWARD_NEUTROPHIL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP

TRIM22 TRIM5 TBC1D8 VPS9D1 ARHGAP5 KARS1 NOD1 TRAFD1 MICB PLSCR2 SLAMF7

7.21e-0739410811M40996
CoexpressionGSE11961_FOLLICULAR_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN

ATP8B3 USP37 FZD4 NOD1 TRAFD1 BRCA1 SLFN13 TPX2

1.83e-062001088M9341
CoexpressionKINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP

CCDC117 PDS5B ZNF93 FAM91A1 NBN MCM3 BRCC3 USP37 DICER1 PTP4A1 BRCA1 LRFN5 KLHL23 TPX2 MIB1 DKC1 SLFN11 BRF2

5.27e-06129010818M80
CoexpressionJOHNSTONE_PARVB_TARGETS_3_DN

ASNSD1 PDS5B NT5E PHOSPHO2 USP37 MDM4 ATP2C1 MICB MTRFR KLHL23 MIB1 CCAR1 DKC1 SASS6

1.50e-0587710814M2241
CoexpressionBLANCO_MELO_HUMAN_PARAINFLUENZA_VIRUS_3_INFECTION_A594_CELLS_UP

NT5E BIRC3 TRIM22 TRIM5 FZD4 CLMP BMPER

2.24e-052041087M34006
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

SMG1 NT5E ZNF195 MDM4 PTP4A1 STAG3L1 CCAR1 STAG3L2 USP48 DYNC1LI2

2.71e-0547410810M40991
CoexpressionHE_LIM_SUN_FETAL_LUNG_C4_CYCLING_NK_CELL

PDS5B SAAL1 MCM3 USP37 BRCA1 SLFN13 MICB MTRFR TPX2 SASS6 CHST2 USP48

2.96e-0569410812M45767
CoexpressionUROSEVIC_RESPONSE_TO_IMIQUIMOD

TRAFD1 BRCA1 MICB

6.28e-05191083M4857
CoexpressionZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_UP

LRRK2 FAM91A1 NBN CPED1 TRIM22 DICER1 TRIM5 TBC1D8 ACSL3 NOD1 TRAFD1 MICB SLFN11 SLAMF7

7.15e-05101210814M40868
CoexpressionSAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN

CYP2C19 CYP2C8 CYP2C9

7.37e-05201083MM1104
CoexpressionTUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_DN

CYP2C19 CYP2C9 PLSCR2

1.29e-04241083MM708
CoexpressionGSE9960_HEALTHY_VS_GRAM_POS_SEPSIS_PBMC_DN

SMG1 BIRC3 NBN TRAFD1 CHST2 SLAMF7

1.69e-041971086M7121
CoexpressionAFFAR_YY1_TARGETS_DN

CYP2C19 CYP2C9 MATN2 MCM3 NEURL1 PLSCR2 CHST2

1.75e-042831087MM1157
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_CXCL9_POS_MACROPHAGE_CELL

BIRC3 NBN VPS9D1 TRAFD1 SLAMF7

1.78e-041261085M45721
CoexpressionGSE42021_TREG_VS_TCONV_PLN_UP

NBN TRIM22 TRIM5 VPS9D1 NOD1 TRAFD1

1.84e-042001086M9572
CoexpressionGSE45365_NK_CELL_VS_CD8_TCELL_MCMV_INFECTION_DN

CYP2C19 NBL1 BIRC3 TBC1D8 TRAFD1 SLAMF7

1.84e-042001086M9961
CoexpressionGSE17812_WT_VS_THPOK_KO_MEMORY_CD8_TCELL_DN

MYO1H BIRC3 NOD1 TPX2 SLAMF7 ARHGAP21

1.84e-042001086M7164
CoexpressionGSE17721_0.5H_VS_24H_CPG_BMDC_DN

LRRK2 BIRC3 CHM SLFN13 SLAMF7 ARHGAP21

1.84e-042001086M4129
CoexpressionGSE21670_STAT3_KO_VS_WT_CD4_TCELL_TGFB_IL6_TREATED_DN

PSAP LRRK2 DAPK1 CPED1 SLAMF7 ARHGAP21

1.84e-042001086M7453
CoexpressionHARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP

NBN TRIM22 TRIM5 FZD4 NOD1 TRAFD1 SLFN13 MICB NEURL1 TPX2 CLMP PLSCR2 SLAMF7

1.86e-0497310813M41080
CoexpressionBLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_UP

NT5E BIRC3 TRIM22 MICB CLMP CHST2 SPOCD1

1.87e-042861087M34008
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAMR1 NBL1 CPED1 LRFN5 CLMP BMPER

4.67e-0617710869ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PAMR1 NBL1 CPED1 LRFN5 CLMP BMPER

4.67e-061771086016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellImmune_cells-Dendritic_cells|Immune_cells / Lineage and Cell class

PSAP MATN2 NBL1 TBC1D8 ARHGAP5 CARD11

5.48e-06182108699c7d4f1e7cd745643ba64b59190113bcd4e348e
ToppCellControl-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

BIRC3 RFPL4AL1 ARHGAP5 RFPL4A CARD11 SLAMF7

5.84e-061841086c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRRK2 DAPK1 ITGA9 GALNT13 PTP4A1 CLMP

6.02e-0618510860d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

BIRC3 RFPL4AL1 ARHGAP5 RFPL4A CARD11 SLAMF7

6.21e-061861086b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CHM ARHGAP5 GLMN SLFN13 DNM2 BRF2

6.40e-061871086c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-cDC1|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRK2 BIRC3 TRIM22 RFPL4AL1 RFPL4A SLAMF7

7.23e-0619110869774d423e448ec2d415261e4ad386a81558129b3
ToppCellControl-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

LRRK2 BIRC3 TBC1D8 NEURL1 CHST2 SLAMF7

7.67e-0619310863479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 MCM3 DAPK1 BRCA1 TPX2 CARD11

7.90e-061941086effd38e51062b225ecabc7e1c50154e65495d559
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Vcan_(SNc)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CCDC168 PIK3C2G ATP2C2 RNF133

1.47e-0561108412de8c495c7f47ecd720f29a573471705603732a
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Vcan_(SNc)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CCDC168 PIK3C2G ATP2C2 RNF133

1.47e-05611084a655232c6d92335eb086723ab9b05eb3a5479b68
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-cDC1|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRRK2 TRIM22 RFPL4AL1 RFPL4A SLAMF7

4.70e-051621085448602d5ff8b5be9614c63540a4d0fe6bdaf23b4
ToppCellBronchial_Brush-Epithelial-Goblet_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

VPS9D1 CARD11 CLMP CHST2 SPOCD1

5.43e-051671085806d1c00c137da0c5f042adf866873eb6dd4bb27
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PAMR1 NBL1 CPED1 GLMN PRKAR1B

5.59e-051681085d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BIRC3 TBC1D8 TRAFD1 SLAMF7 NYAP1

7.15e-051771085aa56129d2d5a73a10e33b7162233a4d9337ee535
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BIRC3 TBC1D8 TRAFD1 SLAMF7 NYAP1

7.15e-051771085d78a6003ce2d15d7771ae385de252eec7e3c3eea
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BIRC3 TBC1D8 TRAFD1 SLAMF7 NYAP1

7.15e-05177108570ca5b6fde2e38af1eb88a7d6e8746edba298191
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver|TCGA-Liver / Sample_Type by Project: Shred V9

CYP2C19 CYP2C8 PAMR1 CPED1 BMPER

7.54e-0517910850e22e840f43ca81a7543dcf33ec17a741cdf7f37
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue|TCGA-Liver / Sample_Type by Project: Shred V9

CYP2C19 CYP2C8 PAMR1 CPED1 BMPER

7.54e-05179108517ba1eedb6ebf039d3b11d099351d0ac6363c8d1
ToppCellASK452-Immune-B_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

MATN2 TRIM5 WFDC3 KLHL23 SLAMF7

7.54e-051791085c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCellTCGA-Liver-Solid_Tissue_Normal|TCGA-Liver / Sample_Type by Project: Shred V9

CYP2C19 CYP2C8 PAMR1 CPED1 BMPER

7.54e-0517910857046f0a426e45fe1b41a25721ee1e33f6fc7f9e3
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue-2|TCGA-Liver / Sample_Type by Project: Shred V9

CYP2C19 CYP2C8 PAMR1 CPED1 BMPER

7.54e-051791085a20bb3ace5be10c5aef330e9268c0ba55f8fee23
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BIRC3 DAPK1 ITGA9 GALNT13 GRAMD2A

8.59e-05184108542ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellControl-Epithelial_alveolar-AT_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DAPK1 ITGA9 GALNT13 PTP4A1 CLMP

8.59e-05184108551e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

PAMR1 MATN2 NBL1 LRFN5 CLMP

8.81e-051851085fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellPBMC-Control-cDC_10|Control / Compartment, Disease Groups and Clusters

NBL1 BIRC3 TBC1D8 ATP2C2 CLMP

8.81e-0518510854b5a7450fed912f340da16065c1e65d626dbe8d1
ToppCellControl-Myeloid-cDC1|World / Disease state, Lineage and Cell class

BIRC3 RFPL4AL1 ARHGAP5 RFPL4A SLAMF7

9.04e-0518610853de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|368C / Donor, Lineage, Cell class and subclass (all cells)

CHM ARHGAP5 GLMN SLFN13 DNM2

9.50e-051881085ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

BIRC3 RFPL4AL1 RFPL4A CARD11 SLAMF7

9.50e-05188108547bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCellkidney_cells-Hypertensive_with+without-CKD|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group

FOLR1 LRRK2 CD46 MDM4 PIK3C2G

9.50e-05188108590188b60ff893754f7938fe8edab79758827168e
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 FOLR1 NBL1 CLMP CPNE4

9.74e-051891085fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NT5E BRCA1 ATP2C2 TPX2 SLFN11

9.99e-051901085250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAMR1 MATN2 NBL1 LRFN5 CLMP

1.02e-041911085f5ce33af56178333730be308253943c54a0724cf
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

MATN2 DAPK1 ITGA9 ITGB4 BMPER

1.05e-041921085c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MATN2 ITGA9 CPED1 LRFN5 CLMP

1.05e-041921085bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6|TCGA-Stomach / Sample_Type by Project: Shred V9

BIRC3 MCM3 ITGB4 ATP2C1 MICB

1.05e-0419210854e689bca7a242f8482e25f273656e2caba8821c0
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAMR1 MATN2 NBL1 LRFN5 CLMP

1.05e-041921085a8b7c539dc3037071bf068f372e4215563e11de4
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAMR1 MATN2 NBL1 LRFN5 CLMP

1.05e-0419210852143e1fad2e88b90d668e12af37b2092d379090f
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAMR1 MATN2 NBL1 LRFN5 CLMP

1.05e-041921085904c003c4f73b1dfc8243cee02aad2676c515e50
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MATN2 ITGA9 CPED1 LRFN5 CLMP

1.05e-0419210850ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell3'_v3-bone_marrow-Myeloid_Monocytic-Nonclassical_monocytes|bone_marrow / Manually curated celltypes from each tissue

PSAP LRRK2 DAPK1 TBC1D8 NEURL1

1.07e-041931085dc309c249d569e93dc2b154e002212a6eee44497
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PAMR1 MATN2 NBL1 LRFN5 CLMP

1.07e-0419310859ab47b360bee1d4f1092c2269e58acebe9584021
ToppCellmyeloid-CD16+_Monocyte|myeloid / Lineage and Cell class

PSAP BIRC3 TBC1D8 NEURL1 CHST2

1.10e-041941085aeeadfeb01827dbc7de6576c76fb2e41a3c59247
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ASNSD1 NT5E BRCA1 TPX2 SLFN11

1.10e-041941085dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NBL1 ITGA9 CPED1 CLMP SPOCD1

1.13e-041951085eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NBL1 ITGA9 CPED1 CLMP SPOCD1

1.13e-04195108544f67437ea65d530133a0240b17f9860d9cc0e99
ToppCellCOVID-19_Mild-Non-classical_Monocyte|COVID-19_Mild / Disease condition and Cell class

BIRC3 TBC1D8 NEURL1 CHST2 SLAMF7

1.13e-041951085dd00facd20a661ef23fa7fd9a02ee377b8f2d1b9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PSAP BIRC3 DICER1 SPOCD1 ARHGAP21

1.13e-0419510851e28617ca55e5f318a228357737b968dfac8cca0
ToppCellCOVID-19_Mild-Non-classical_Monocyte-|COVID-19_Mild / Disease condition and Cell class

BIRC3 TBC1D8 NEURL1 CHST2 SLAMF7

1.13e-0419510850295d9897830987eec74f51178e14fb0a83723dc
ToppCell15-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high|Trachea / Age, Tissue, Lineage and Cell class

PAMR1 MATN2 THSD7B LRFN5 CLMP

1.16e-04196108554aefcebf13704f51de84379e2e22ec0734b9461
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

NT5E LRRK2 DAPK1 PTP4A1 CLMP

1.18e-04197108544a59dfb889577b3160a5b13ada1276771a00241
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

DAPK1 TRIM22 TRIM5 TRAFD1 SLAMF7

1.21e-0419810854b078714c49e7befb7b113d72485e712236d35fa
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 MDM4 TRIM22 SLFN13 ZNF292

1.24e-041991085f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MATN2 NBL1 KLHL23 CLMP BMPER

1.24e-0419910853a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCellTransverse-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

LRRK2 WFDC3 NOD1 BRCA1 TPX2

1.24e-041991085170ae68963d31f3b821b6f0e8f0c039bea0bc981
ComputationalCytochrome P450.

CYP2C19 CYP2C8 CYP2C9

5.76e-0514603MODULE_106
Drugbufuralol

CYP2C19 CYP2C8 CYP2C9

1.03e-0651083ctd:C010831
Drug4,4'-cyclohexylidenebisphenol

CYP2C19 CYP2C8 CYP2C9

2.05e-0661083ctd:C570106
Drug4',5-dihydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9

2.05e-0661083CID003052567
DrugAC1O5Z5L

CYP2C19 CYP2C8 CYP2C9

2.05e-0661083CID006443527
Drug3'-hydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9

2.05e-0661083CID000112230
Drugnickel nitrate

FOLR3 NBL1 NBN

2.05e-0661083CID000025736
Drug16-O-demethylaconitine

CYP2C19 CYP2C8 CYP2C9

3.58e-0671083ctd:C486136
Drug5-fluorotryptamine

CYP2C19 CYP2C8 CYP2C9

3.58e-0671083ctd:C034536
Drug6-Fluoro-6-desoxyoxymorphone

CYP2C19 CYP2C8 CYP2C9

3.58e-0671083CID005486899
Drug13-hydroxyeicosatetraenoic acid

CYP2C19 CYP2C8 CYP2C9

5.71e-0681083CID006439499
Drug11-HODE

CYP2C19 CYP2C8 CYP2C9

5.71e-0681083CID006438497
Drug5-bromotryptamine

CYP2C19 CYP2C8 CYP2C9

5.71e-0681083ctd:C040997
Drug1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid

CYP2C19 CYP2C8 CYP2C9

5.71e-0681083ctd:C585955
DrugTryptamines

CYP2C19 CYP2C8 CYP2C9

8.54e-0691083ctd:D014363
Drug5-chlorotryptamine

CYP2C19 CYP2C8 CYP2C9

8.54e-0691083ctd:C529169
Drug3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate

CYP2C19 CYP2C8 CYP2C9

8.54e-0691083ctd:C109602
Drug5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid

CYP2C19 CYP2C8 CYP2C9

8.54e-0691083ctd:C000588958
Drugnorketobemidone

CYP2C19 CYP2C8 CYP2C9

1.22e-05101083CID000161154
Drugsitaxsentan

CYP2C19 CYP2C8 CYP2C9

1.22e-05101083ctd:C106276
DrugHaloperidol metabolite I

CYP2C19 CYP2C8 CYP2C9

1.67e-05111083CID000038282
Drugtrans-1,2-dihydro-1,2-naphthalenediol

CYP2C19 CYP2C8 CYP2C9

1.67e-05111083ctd:C507866
Drug5-hydroxydiclofenac

CYP2C19 CYP2C8 CYP2C9

2.21e-05121083CID003052566
Drug4-(N-propionylanilino)piperidine

CYP2C19 CYP2C8 CYP2C9

2.21e-05121083CID000259381
Drugcarveol

CYP2C19 CYP2C8 CYP2C9

2.21e-05121083CID000007438
Drugdesethylamodiaquine

CYP2C19 CYP2C8 CYP2C9

2.21e-05121083ctd:C047386
Drugnorclozapine

CYP2C19 CYP2C8 CYP2C9

2.21e-05121083ctd:C058272
Drugdibenzylfluorescein

CYP2C19 CYP2C9

2.23e-0521082ctd:C558664
DrugN-bromophthalimide

NBL1 NBN

2.23e-0521082CID000075542
Drugformarin

NBL1 NBN

2.23e-0521082CID000009333
Drugprimidone

CYP2C19 CYP2C8 CYP2C9 NBL1

2.80e-05371084CID000004909
DrugAC1L18GM

CYP2C19 CYP2C8 CYP2C9

2.87e-05131083CID000000092
Drug7-hydroxyquinoline

CYP2C19 CYP2C8 CYP2C9

2.87e-05131083CID000011378
Drug1'-hydroxymidazolam

CYP2C19 CYP2C8 CYP2C9

2.87e-05131083CID000107917
Drugclozapine N-oxide

CYP2C19 CYP2C8 CYP2C9

2.87e-05131083CID000036727
Drugpropionanilide

CYP2C19 CYP2C8 CYP2C9

3.64e-05141083CID000012107
Drug5-MeO-DIPT

CYP2C19 CYP2C8 CYP2C9

3.64e-05141083CID000151182
Drug2'-(glutathion-S-yl)-deschlorodiclofenac

CYP2C19 CYP2C8 CYP2C9

4.53e-05151083ctd:C586542
Drug4-hydroxymephenytoin

CYP2C19 CYP2C8 CYP2C9

4.53e-05151083CID000119507
DrugL 654969

CYP2C19 CYP2C8 CYP2C9 NBN

4.66e-05421084CID000005218
DrugRo 31-8959

CYP2C19 CYP2C8 CYP2C9 LRRK2 NBN

5.01e-05841085CID000060787
Drug4,4'-(hexafluoroisopropylidene)diphenol

CYP2C19 CYP2C8 CYP2C9

5.56e-05161083ctd:C571725
Drug6-hydroxychlorzoxazone

CYP2C19 CYP2C8 CYP2C9

5.56e-05161083CID000002734
DrugAmodiaquine

CYP2C19 CYP2C8 CYP2C9

5.56e-05161083ctd:D000655
Drug1-phenylazo-2-naphthol

CYP2C19 CYP2C8 CYP2C9

5.56e-05161083ctd:C024336
Drugpicoxystrobin

CYP2C19 CYP2C9

6.67e-0531082ctd:C556557
DrugCyclohexenes

CYP2C8 CYP2C9

6.67e-0531082ctd:D053138
Drugmono-N-demethyladinazolam

CYP2C19 CYP2C9

6.67e-0531082ctd:C050132
Drugortho-Aminobenzoates

CYP2C8 CYP2C9

6.67e-0531082ctd:D062367
Drug5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione

CYP2C19 CYP2C8

6.67e-0531082ctd:C502236
Drug2-hydroxychlorpropamide

CYP2C19 CYP2C9

6.67e-0531082CID003082454
DrugDelavirdine

CYP2C19 CYP2C9

6.67e-0531082ctd:D020008
Drugdiosmetin

CYP2C19 CYP2C8 CYP2C9

6.72e-05171083ctd:C039602
DrugAzamulinum

CYP2C19 CYP2C8 CYP2C9

8.04e-05181083CID003086060
Drug7-benzyloxyquinoline

CYP2C19 CYP2C8 CYP2C9

8.04e-05181083CID003035604
Drugpleuromutilin

CYP2C19 CYP2C8 CYP2C9

8.04e-05181083CID000031326
DrugD 703

CYP2C19 CYP2C8 CYP2C9

8.04e-05181083CID000054088
Drug2,4-oxazolidinedione

CYP2C19 CYP2C8 CYP2C9

8.04e-05181083CID000097389
Drughydroxytolbutamide

CYP2C19 CYP2C8 CYP2C9

9.52e-05191083CID000003656
Drug6|A-Hydroxycortisol

CYP2C19 CYP2C8 CYP2C9

9.52e-05191083CID000150985
Druglovastatin acid

CYP2C8 CYP2C9 NBL1

1.12e-04201083CID000064727
DrugN'-nitrosoanatabine

CYP2C19 CYP2C8 CYP2C9

1.12e-04201083CID000051291
Drug3C etc

CYP2C19 CYP2C8 CYP2C9

1.12e-04201083CID000164045
Drugtamoxifen N-oxide

CYP2C19 CYP2C8 CYP2C9

1.12e-04201083CID003033895
Drug3-methoxymorphinan

CYP2C19 CYP2C8 CYP2C9

1.12e-04201083CID000001671
Drugglimepiride

CYP2C19 CYP2C8 CYP2C9 NT5E

1.26e-04541084CID000003476
DrugAC1LABND

NT5E NBL1 PHOSPHO2 KLHL23

1.26e-04541084CID000485098
DrugAC1L21VM

CYP2C19 CYP2C8 CYP2C9

1.30e-04211083CID000039524
Drugnirvanol

CYP2C19 CYP2C8 CYP2C9

1.30e-04211083CID000091480
Drugzafirlukast

CYP2C19 CYP2C8 CYP2C9

1.30e-04211083ctd:C062735
Drugthiocoraline

CYP2C8 CYP2C9

1.33e-0441082ctd:C109005
Drug1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea

CYP2C19 CYP2C9

1.33e-0441082ctd:C558737
Drug4-isopropylphenol

CYP2C8 CYP2C9

1.33e-0441082ctd:C028690
Drugmethysticin

CYP2C19 CYP2C9

1.33e-0441082ctd:C076881
DrugSulfadiazine

CYP2C8 CYP2C9

1.33e-0441082ctd:D013411
Drugrabeprazole-thioether

CYP2C19 CYP2C9

1.33e-0441082ctd:C523099
Drug7,8-dihydromethysticin

CYP2C19 CYP2C9

1.33e-0441082ctd:C107882
DrugDBDMH

NBL1 NBN

1.33e-0441082CID000006479
DrugVincristine

PDS5B CYP2C8 CYP2C9 NT5E MATN2 HECTD4 BIRC3 NBN USP37 CHM TRIM22 ARHGAP5 SLFN13 KLHL23 CCAR1 SLAMF7

1.41e-04118210816ctd:D014750
DrugN'-nitrosoanabasine

CYP2C19 CYP2C8 CYP2C9

1.50e-04221083CID000014335
Drugazoline

CYP2C19 CYP2C8 CYP2C9

1.50e-04221083CID003013050
DrugBortezomib

CYP2C19 CYP2C9 PSAP NT5E FOLR1 BIRC3 BRCC3 TRAFD1 BRCA1 CCAR1 CHST2 DNM2 BRF2

1.70e-0483810813ctd:D000069286
Drug3'-amino-3'-deoxythymidine

CYP2C19 CYP2C8 CYP2C9

1.72e-04231083CID000108074
DrugN-nitrosomethylethylamine

CYP2C19 CYP2C8 CYP2C9

1.95e-04241083CID000025418
Drugcinnamic acid

CYP2C19 CYP2C8 CYP2C9

1.95e-04241083ctd:C029010
Drug2-oxo-clopidogrel

CYP2C19 CYP2C9

2.21e-0451082ctd:C540904
Drugbenfuracarb

CYP2C19 CYP2C9

2.21e-0451082ctd:C096128
Drugmono(2-ethyl-5-hydroxyhexyl) phthalate

CYP2C19 CYP2C9

2.21e-0451082ctd:C479069
Drugmethylpropylnitrosamine

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083CID000013545
DrugAconitine

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083ctd:D000157
DrugTranylcypromine

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083ctd:D014191
DrugTolbutamide

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083ctd:D014044
DrugAC1L44DC

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083CID000150456
DrugTiclopidine

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083ctd:D013988
DrugN-nitrosopiperidine

CYP2C19 CYP2C8 CYP2C9

2.21e-04251083CID000007526
Drugtegaserod

CYP2C19 CYP2C8 CYP2C9

2.49e-04261083CID005487301
Drug11-HETE

CYP2C19 CYP2C8 CYP2C9

2.49e-04261083CID000001406
Drug24-methylenelanost-8-en-3beta-ol

CYP2C19 CYP2C8 CYP2C9

2.49e-04261083CID000065172
Drugadenosine kinase inhibitor

NT5E PHOSPHO2 KLHL23

2.49e-04261083CID000001973
Drug1,4-naphthoquinone

CYP2C19 CYP2C8 CYP2C9

2.49e-04261083ctd:C035342
Druglicochalcone A

CYP2C19 CYP2C8 CYP2C9

2.79e-04271083ctd:C070840
DiseaseX-21258 measurement

CYP2C19 CYP2C9

3.47e-0531012EFO_0800802
DiseaseHailey-Hailey disease (implicated_via_orthology)

ATP2C1 ATP2C2

1.72e-0461012DOID:0050429 (implicated_via_orthology)
DiseaseAdenoid Cystic Carcinoma

DAPK1 ITGB4 BRCA1 STAG3L1

3.94e-041001014C0010606
Diseasetestosterone measurement

ATP8B3 CYP2C8 SAAL1 C16orf96 PKDREJ GALNT13 PTP4A1 TBC1D8 GLMN SPOCD1 USP48 USH2A ARHGAP21

4.11e-04127510113EFO_0004908
DiseaseMalignant neoplasm of salivary gland

DAPK1 ITGB4 STAG3L1

4.98e-04451013C0220636
DiseaseSalivary Gland Neoplasms

DAPK1 ITGB4 STAG3L1

5.66e-04471013C0036095
DiseaseX-11308 measurement

CYP2C19 CYP2C9

6.25e-04111012EFO_0800693
Diseasethymol sulfate measurement

CYP2C19 CYP2C9

7.49e-04121012EFO_0021170
Diseasenervous system disorder

CYP2C8 CYP2C9 NOD1

8.05e-04531013C0027765
Diseaseaplastic anemia (is_implicated_in)

NBN DKC1

8.83e-04131012DOID:12449 (is_implicated_in)
DiseaseHereditary Breast and Ovarian Cancer Syndrome

NBN BRCA1

1.03e-03141012C0677776
DiseaseRhabdomyosarcoma

NBN DICER1

1.18e-03151012C0035412
Disease16a-hydroxy DHEA 3-sulfate measurement

CYP2C8 CYP2C9

1.18e-03151012EFO_0800301
Diseaseandro steroid monosulfate C19H28O6S (1) measurement

CYP2C8 CYP2C9

1.35e-03161012EFO_0800305
DiseaseMAJOR AFFECTIVE DISORDER 2

ITGA9 FZD4

1.53e-03171012C1839839
Diseasebreast cancer (is_implicated_in)

CYP2C19 NBN ACSL3 BRCA1

1.79e-031501014DOID:1612 (is_implicated_in)
Diseaseestrogen-receptor negative breast cancer

FAM91A1 MDM4 PPIL3

1.88e-03711013EFO_1000650
Diseaselymphocyte percentage of leukocytes

NBN TBC1D8 GLMN STAG3L1 CARD11 STAG3L2 STAG3L3 ZNF292

2.05e-036651018EFO_0007993
Diseaseurinary bladder cancer (is_implicated_in)

CYP2C9 DAPK1 BRCA1

2.28e-03761013DOID:11054 (is_implicated_in)
DiseaseAttention deficit hyperactivity disorder

GRM5 ZNF292

3.05e-03241012C1263846
Diseaseosteonecrosis

CYP2C8 LRFN5

3.31e-03251012EFO_0004259

Protein segments in the cluster

PeptideGeneStartEntry
IRVLASECIKKLCPV

CATSPERG

336

Q6ZRH7
VQVRGLETEKIKCCL

DAPK1

1196

P53355
CPVRKKRITEAELCA

CCDC117

81

Q8IWD4
TVTIGVETPKCLCKV

CPED1

606

A4D0V7
DPSVLIKTAIRCCKA

CCAR1

516

Q8IX12
CLVEELRKTKASPCD

CYP2C8

151

P10632
VVCKDCAPSLRKCPI

BIRC3

576

Q13489
CCRVTPKQKALIVAL

ATP8B3

911

O60423
ERVVALICCEKLHKI

DICER1

691

Q9UPY3
IVKKLPIVETLGCCN

ATP2C1

331

P98194
VKKLPIVETLGCCSV

ATP2C2

361

O75185
CLVVDKESRKCKAII

CHM

406

P24386
AICALCAKDPVKERR

PDS5B

941

Q9NTI5
IEEVKKICSVLGCVE

PIK3C2G

431

O75747
KISCCPRLKILRLEE

LRRC57

171

Q8N9N7
IGIAVKAQICPKRCV

LRFN5

11

Q96NI6
CSEPCEKGQIKVIRK

GRM5

511

P41594
CKKCTEGPIDLVFVI

MATN2

646

O00339
PECKVVKCRFPVVEN

CD46

221

P15529
GASCPICKKEIQLVI

MDM4

471

O15151
DIKICTLPEKCAVDK

FAM91A1

181

Q658Y4
PVLVVCTKCDAVSVL

DYNC1LI2

226

O43237
KREDVLKISGPCIVC

PLSCR2

211

Q9NRY7
EIVCACPTQPDKVRK

NOD1

56

Q9Y239
CQVCEKESSPKLVEL

LRRK2

746

Q5S007
KERILNVPLCKEDCE

FOLR3

126

P41439
VIIIILCVPCCKKKT

MICB

321

Q29980
KQIIRCPVCLKDLEE

RFPL4A

6

A6NLU0
CPVCLKDLEEAVQLK

RFPL4A

11

A6NLU0
PRVDKLVEKILHCSC

NBL1

106

P41271
LKIVVRESCILITKC

HECTD4

411

Q9Y4D8
KEPCLKCVDLVIQEL

DNM2

421

P50570
KKAPVKSCTECVRVD

ITGB4

31

P16144
RCPKNLCKKVVLIEF

PHOSPHO2

146

Q8TCD6
SLCSPRVKKCLICKE

MIB1

841

Q86YT6
KEDRKTVVCPIIDVI

GALNT13

226

Q8IUC8
CVEGIVTKCSLVRPK

MCM3

126

P25205
RKVLDCEKPGISCLT

ITGA9

886

Q13797
ICLELIKEPVSTKCD

BRCA1

26

P38398
CLSVKRRCEPVLKEF

FZD4

121

Q9ULV1
IPCLQKRCIDKFKAT

HEATR5A

1846

Q86XA9
CPELEKESRRILCSK

KLHL23

151

Q8NBE8
VCLNKEVTCKREKCP

BMPER

71

Q8N8U9
EVTCKREKCPVLSRD

BMPER

76

Q8N8U9
CLVEELRKTKASPCD

CYP2C19

151

P33261
LFKRVKCISCDRPVE

C16orf96

906

A6NNT2
PCLTKVELRVACKGI

CPNE4

21

Q96A23
LQKKEVLVGCCVLIT

BRF2

111

Q9HAW0
VLKDCCKILDNTVLP

DCTN5

121

Q9BTE1
VEVKKVMACPRCILT

MTARC2

261

Q969Z3
SVAVKKRVLCLPRDE

ASNSD1

291

Q9NWL6
LKDCIVHLCISKPER

PRKAR1B

31

P31321
EKCVKNLCRTPQLII

GLIPR1L1

196

Q6UWM5
ECRKETLIITPPSCK

CCDC168

6846

Q8NDH2
CLVEELRKTKASPCD

CYP2C9

151

P11712
VPLEEVVLKVCSCAL

GRAMD2A

81

Q8IUY3
PKVTGCLIVCIERAT

DKC1

126

O60832
PLQVKCKDCEERRVS

SASS6

11

Q6UVJ0
VLAKSKCPRLREICV

SAAL1

101

Q96ER3
GKVCVRAKVLCLSPE

SLFN13

506

Q68D06
RVCRLKEKELEALPC

CARD11

1101

Q9BXL7
KERVLNVPLCKEDCE

FOLR1

126

P15328
ICIKACREPKISDLV

PAMR1

341

Q6UXH9
DGKLLEVIERKRCVC

NYAP1

776

Q6ZVC0
VGPVVRCLLCKDKED

GLMN

66

Q92990
ELCKAVRCQKPESIC

USH2A

3166

O75445
KQIIRCPVCLKDLEE

RFPL4AL1

6

F8VTS6
CPVCLKDLEEAVQLK

RFPL4AL1

11

F8VTS6
CKCDILKVLGIQVVV

RNF133

296

Q8WVZ7
KKHEETECPLRLAVC

TRAFD1

76

O14545
KILDDICVAKAVECP

KARS1

421

Q15046
KVTIKTICALICGRP

NBN

156

O60934
PACTVKKARVVCLPV

PKDREJ

1046

Q9NTG1
PVCEDQLKEIERCIK

SMG1

2736

Q96Q15
GKVCVRAKVLCLSPE

SLFN11

506

Q7Z7L1
KKPVIIAATKCDECV

ARHGAP5

191

Q13017
KVTCRDVLPEIRAIC

STAG3L1

11

P0CL83
LCSEAVPLLVKVIKC

RANBP6

951

O60518
GDRVVKLDVLCTKCR

NT5E

466

P21589
KVCLESAVELPKILC

BRCC3

226

P46736
RVGAPLVCCEIKLKN

ACSL3

496

O95573
TEIKRVAEEKVTLPC

CLMP

21

Q9H6B4
VVGLVDDRVCKKCPP

CHST2

271

Q9Y4C5
VCCPKELLEQKAVLE

CNKSR1

186

Q969H4
LVNVKEEVTCPICLE

TRIM5

6

Q9C035
DEVKCRVLLCDPEAK

PDCD11

501

Q14690
LKRCITDETCPGVKK

WFDC3

86

Q8IUB2
LQLIKRCESVDECKV

ZNF93

111

P35789
CVVLKHIPSGIVVKC

MTRFR

81

Q9H3J6
CCPICRRPIKDIIKT

NEURL1

556

O76050
KASVCKTIACLLPED

RLF

391

Q13129
CVRCVPTDKAIKKFV

RPS26P11

26

Q5JNZ5
LASICPAKAKDVCVV

SPOCD1

916

Q6ZMY3
DIKIEVFCERTPKTC

PPIL3

11

Q9H2H8
CCKIILPLREVVSIE

TBC1D8

336

O95759
EVKISICKTISCLLP

ZNF292

366

O60281
KVTCRDVLPEIRAIC

STAG3L2

11

P0CL84
EKKRVDICRETPNIC

SLAMF7

261

Q9NQ25
PTVKSLPCDICKDVV

PSAP

56

P07602
SIICKACGEIIPKRE

USP37

486

Q86T82
KVTCRDVLPEIRAIC

STAG3L3

11

P0CL85
LESCPQKKLECIVRT

VPS9D1

521

Q9Y2B5
TVRPCFLPCKKDCIV

THSD7B

726

Q9C0I4
IPLIVDICCKLVEER

ARHGAP21

1161

Q5T5U3
PRLTVKALCKECVVE

USP48

546

Q86UV5
KVDIEKEVTCPICLE

TRIM22

6

Q8IYM9
KTHPICLCLDKVEVE

UHRF1BP1

76

Q6BDS2
SLVKIKFREEPGCCI

PTP4A1

86

Q93096
RIKVCEKRPSIDLCI

WFDC10B

31

Q8IUB3
TVCKPGLITCLEQRK

ZNF195

46

O14628
KAKRCATPVIIDEIL

TPX2

141

Q9ULW0
RKIEAKTEEVICPLT

MYO1H

321

Q8N1T3