Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh-affinity L-glutamate transmembrane transporter activity

SLC1A3 SLC1A7

1.10e-045672GO:0005314
GeneOntologyMolecularFunctionglutamate:sodium symporter activity

SLC1A3 SLC1A7

1.10e-045672GO:0015501
GeneOntologyBiologicalProcesspositive regulation of protein oxidation

TRABD2A TRABD2B

1.04e-052672GO:1904808
GeneOntologyBiologicalProcessregulation of protein oxidation

TRABD2A TRABD2B

1.04e-052672GO:1904806
GeneOntologyBiologicalProcessfocal adhesion assembly

THBS1 DLC1 LRP1 ITGA2 SMAD3

1.59e-0597675GO:0048041
GeneOntologyBiologicalProcessnegative regulation of cell-substrate junction organization

THBS1 DLC1 LRP1

2.16e-0517673GO:0150118
GeneOntologyBiologicalProcessnegative regulation of focal adhesion assembly

THBS1 DLC1 LRP1

2.16e-0517673GO:0051895
GeneOntologyBiologicalProcesscell-substrate junction assembly

THBS1 DLC1 LRP1 ITGA2 SMAD3

2.67e-05108675GO:0007044
GeneOntologyBiologicalProcesscell-substrate junction organization

THBS1 DLC1 LRP1 ITGA2 SMAD3

3.62e-05115675GO:0150115
GeneOntologyBiologicalProcessregulation of focal adhesion assembly

THBS1 DLC1 LRP1 SMAD3

7.93e-0570674GO:0051893
GeneOntologyBiologicalProcessregulation of cell-substrate junction assembly

THBS1 DLC1 LRP1 SMAD3

7.93e-0570674GO:0090109
GeneOntologyBiologicalProcessregulation of cell-substrate junction organization

THBS1 DLC1 LRP1 SMAD3

1.04e-0475674GO:0150116
GeneOntologyBiologicalProcessresponse to nitrogen compound

SCN11A THBS1 FAT1 INHBB PKLR LRP1 AHSG ITGA2 SLC1A3 SMAD3 IFNA16 SOS1 SOS2

1.96e-0412726713GO:1901698
GeneOntologyBiologicalProcessresponse to monosaccharide

CACNA1D THBS1 PKLR LRP1 ITGA2 SMAD3

2.53e-04272676GO:0034284
GeneOntologyBiologicalProcessregulation of pro-B cell differentiation

SOS1 SOS2

2.87e-048672GO:2000973
GeneOntologyBiologicalProcessnegative regulation of cell junction assembly

THBS1 DLC1 LRP1

3.20e-0441673GO:1901889
DomainTraB

TRABD2A TRABD2B

3.91e-053682PF01963
DomainPheromone_shutdown_TraB

TRABD2A TRABD2B

3.91e-053682IPR002816
DomainNa-dicarboxylate_symporter

SLC1A3 SLC1A7

2.71e-047682IPR001991
DomainNA_DICARBOXYL_SYMP_1

SLC1A3 SLC1A7

2.71e-047682PS00713
DomainNA_DICARBOXYL_SYMP_2

SLC1A3 SLC1A7

2.71e-047682PS00714
DomainNa-dicarboxylate_symporter_CS

SLC1A3 SLC1A7

2.71e-047682IPR018107
DomainSDF

SLC1A3 SLC1A7

2.71e-047682PF00375
Domain-

SLC1A3 SLC1A7

2.71e-0476821.10.3860.10
DomainDHC_N1

DYNC2H1 DNAH5

3.61e-048682PF08385
DomainDynein_heavy_dom-1

DYNC2H1 DNAH5

3.61e-048682IPR013594
DomainNa_channel_asu

SCN11A SCN7A

5.77e-0410682IPR001696
DomainNa_trans_assoc

SCN11A SCN7A

5.77e-0410682IPR010526
DomainNa_trans_assoc

SCN11A SCN7A

5.77e-0410682PF06512
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH5

1.16e-0314682IPR024317
DomainDynein_HC_stalk

DYNC2H1 DNAH5

1.16e-0314682IPR024743
DomainDynein_heavy_dom-2

DYNC2H1 DNAH5

1.16e-0314682IPR013602
DomainDHC_N2

DYNC2H1 DNAH5

1.16e-0314682PF08393
DomainMT

DYNC2H1 DNAH5

1.16e-0314682PF12777
DomainAAA_8

DYNC2H1 DNAH5

1.16e-0314682PF12780
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH5

1.16e-0314682IPR011704
DomainRas_G-nucl-exch_fac_CS

SOS1 SOS2

1.16e-0314682IPR019804
DomainAAA_5

DYNC2H1 DNAH5

1.16e-0314682PF07728
DomainChannel_four-helix_dom

CACNA1D SCN11A SCN7A

1.17e-0357683IPR027359
Domain-

CACNA1D SCN11A SCN7A

1.17e-03576831.20.120.350
DomainDHC_fam

DYNC2H1 DNAH5

1.33e-0315682IPR026983
DomainDynein_heavy_dom

DYNC2H1 DNAH5

1.33e-0315682IPR004273
DomainDynein_heavy

DYNC2H1 DNAH5

1.33e-0315682PF03028
DomainDH_1

AKAP13 SOS1 SOS2

1.57e-0363683PS00741
DomainAAA+_ATPase

NSF DYNC2H1 RNF213 DNAH5

1.88e-03144684IPR003593
DomainAAA

NSF DYNC2H1 RNF213 DNAH5

1.88e-03144684SM00382
DomainRhoGEF

AKAP13 SOS1 SOS2

1.95e-0368683SM00325
DomainRhoGEF

AKAP13 SOS1 SOS2

2.12e-0370683PF00621
DomainDH_2

AKAP13 SOS1 SOS2

2.12e-0370683PS50010
DomainDH-domain

AKAP13 SOS1 SOS2

2.21e-0371683IPR000219
Domain-

AKAP13 SOS1 SOS2

2.21e-03716831.20.900.10
DomainRasGEFN

SOS1 SOS2

2.38e-0320682SM00229
DomainRasGEF_N

SOS1 SOS2

2.62e-0321682PF00618
DomainRas-like_Gua-exchang_fac_N

SOS1 SOS2

2.88e-0322682IPR000651
DomainRASGEF_NTER

SOS1 SOS2

2.88e-0322682PS50212
DomainEphrin_rec_like

ELAPOR2 TG

3.71e-0325682SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

ELAPOR2 TG

3.71e-0325682IPR011641
DomainEGF_CA

THBS1 FAT1 LRP1

3.81e-0386683PF07645
DomainRASGEF

SOS1 SOS2

4.01e-0326682PS00720
DomainRASGEF_CAT

SOS1 SOS2

4.98e-0329682PS50009
DomainRasGEF

SOS1 SOS2

5.32e-0330682PF00617
Domain-

SOS1 SOS2

5.32e-03306821.10.840.10
DomainRas_GEF_dom

SOS1 SOS2

5.32e-0330682IPR023578
DomainRASGEF_cat_dom

SOS1 SOS2

5.32e-0330682IPR001895
DomainRasGEF

SOS1 SOS2

5.32e-0330682SM00147
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN11A SPTAN1 SCN7A

1.66e-0431493M877
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PATHWAY_ADAPTOR_PROTEINS

SOS1 SOS2

5.23e-0410492M47930
PathwayWP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY

SMAD3 SOS1 SOS2

5.39e-0446493M39828
PathwayKEGG_FOCAL_ADHESION

THBS1 MYL5 ITGA2 SOS1 SOS2

6.14e-04199495M7253
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

SOS1 SOS2

6.38e-0411492MM15578
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY

SOS1 SOS2

6.38e-0411492M47436
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY

SOS1 SOS2

6.38e-0411492M47432
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

DOK1 CACNA1D SCN11A SPTAN1 SCN7A ITGA2 SOS1 SOS2

7.50e-04575498M29853
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

AKAP13 SOS1 SOS2

7.74e-0452493MM14743
PathwayREACTOME_L1CAM_INTERACTIONS

SCN11A SPTAN1 SCN7A ITGA2

8.12e-04121494M872
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

SOS1 SOS2

9.01e-0413492M47594
PathwayREACTOME_ACTIVATION_OF_RAC1

SOS1 SOS2

9.01e-0413492M6322
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.05e-0314492M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.05e-0314492M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.05e-0314492M47366
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

SOS1 SOS2

1.05e-0314492M47390
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.05e-0314492M47378
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

SOS1 SOS2

1.05e-0314492M27858
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.05e-0314492M47488
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

AKAP13 SOS1 SOS2

1.12e-0359493M11215
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47367
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47389
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47375
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47474
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47475
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.21e-0315492M47531
PathwayREACTOME_SIGNALING_BY_ACTIVIN

INHBB SMAD3

1.21e-0315492MM14593
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

CACNA1D SPTAN1 SOS1

1.35e-0363493M11187
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.38e-0316492M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.38e-0316492M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.38e-0316492M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.38e-0316492M47804
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

SOS1 SOS2

1.38e-0316492M39882
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.38e-0316492M47483
PathwayWP_IRON_METABOLISM_DISORDERS

PANK2 TFRC

1.56e-0317492M48053
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.56e-0317492M47376
PathwayREACTOME_SIGNALING_BY_ACTIVIN

INHBB SMAD3

1.56e-0317492M26965
PathwayREACTOME_RHOB_GTPASE_CYCLE

DLC1 AKAP13 TFRC

1.76e-0369493MM15596
PathwayREACTOME_RHOB_GTPASE_CYCLE

DLC1 AKAP13 TFRC

1.83e-0370493M41806
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

AKAP13 SOS1 SOS2

1.83e-0370493MM14824
PathwayREACTOME_RHOC_GTPASE_CYCLE

DLC1 AKAP13 TFRC

1.83e-0370493MM15597
PathwayWP_HEPATITIS_B_INFECTION

SMAD3 IFNA16 SOS1 SOS2

1.84e-03151494M39801
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

SMAD3 SOS1 SOS2

2.07e-0373493M321
PathwayREACTOME_RHOC_GTPASE_CYCLE

DLC1 AKAP13 TFRC

2.15e-0374493M41807
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

AKAP13 SOS1 SOS2

2.32e-0376493M19832
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

AKAP13 SOS1 SOS2

2.41e-0377493MM15044
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

AKAP13 SOS1 SOS2

2.69e-0380493M800
Pubmed

A novel proteomic screen for peptide-protein interactions.

SNX18 SOS1 SOS2

5.95e-07968314679214
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

DLC1 AKAP13 SOS1 SOS2

9.38e-073868419911011
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

NSF SCAMP3 PUM1 PC TFRC SOS1 SOS2

3.33e-0632368724797263
Pubmed

Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates.

TRABD2A TRABD2B

3.77e-06268225354456
Pubmed

A homologue of the Drosophila Son of sevenless gene maps to mouse chromosome 17.

SOS1 SOS2

3.77e-0626828307589
Pubmed

Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans.

THBS1 LRP1

3.77e-06268214991768
Pubmed

Antigen-induced regulation of T-cell motility, interaction with antigen-presenting cells and activation through endogenous thrombospondin-1 and its receptors.

THBS1 LRP1

3.77e-06268225393517
Pubmed

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

SOS1 SOS2

3.77e-06268225973715
Pubmed

Nomenclature of voltage-gated sodium channels.

SCN11A SCN7A

3.77e-06268211144347
Pubmed

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

SOS1 SOS2

3.77e-0626821631150
Pubmed

SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.

SOS1 SOS2

3.77e-06268234205562
Pubmed

Cellular internalization and degradation of thrombospondin-1 is mediated by the amino-terminal heparin binding domain (HBD). High affinity interaction of dimeric HBD with the low density lipoprotein receptor-related protein.

THBS1 LRP1

3.77e-0626829045712
Pubmed

The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.

SOS1 SOS2

3.77e-0626829372945
Pubmed

Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1).

THBS1 LRP1

3.77e-06268217154366
Pubmed

Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.

SOS1 SOS2

3.77e-06268236010887
Pubmed

Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome.

SOS1 SOS2

3.77e-0626828275713
Pubmed

Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G.

NSF TFRC

3.77e-06268227995606
Pubmed

Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1.

THBS1 LRP1

3.77e-06268224877199
Pubmed

Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.

THBS1 SCN7A PC

4.77e-061768310549128
Pubmed

The Lbc Rho guanine nucleotide exchange factor α-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation.

CTNNAL1 AKAP13

1.13e-05368220696764
Pubmed

A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2.

THBS1 SCN7A

1.13e-0536828250913
Pubmed

A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.

LRP1 SLC1A3

1.13e-05368222674573
Pubmed

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.

SOS1 SOS2

1.13e-05368224043312
Pubmed

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.

SOS1 SOS2

1.13e-05368212628188
Pubmed

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.

THBS1 LRP1

1.13e-05368218653767
Pubmed

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.

SOS1 SOS2

1.13e-05368229844066
Pubmed

Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.

LRP1 TFRC

1.13e-05368221252237
Pubmed

Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.

INHBB SMAD3

1.13e-05368225557874
Pubmed

Deletion of LRP1 From Astrocytes Modifies Neuronal Network Activity in an in vitro Model of the Tripartite Synapse.

LRP1 SLC1A3

1.13e-05368233519378
Pubmed

Deconstructing Ras signaling in the thymus.

SOS1 SOS2

1.13e-05368222586275
Pubmed

Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.

SOS1 SOS2

1.13e-0536827829473
Pubmed

Differential interactions of human Sos1 and Sos2 with Grb2.

SOS1 SOS2

1.13e-0536827629138
Pubmed

Deciphering the complex role of thrombospondin-1 in glioblastoma development.

THBS1 SMAD3

1.13e-05368230850588
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

SPTAN1 SOS1 SOS2

1.59e-05256838493579
Pubmed

Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation.

CTNNAL1 AKAP13

2.25e-05468212270917
Pubmed

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.

TRABD2A TRABD2B

2.25e-05468222726442
Pubmed

High-density presynaptic transporters are required for glutamate removal from the first visual synapse.

SLC1A3 SLC1A7

2.25e-05468216600856
Pubmed

Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.

DYNC2H1 RNF213

2.25e-05468226147384
Pubmed

Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation.

THBS1 ITGA2

2.25e-05468210397731
Pubmed

A new member of the amphiphysin family connecting endocytosis and signal transduction pathways.

SOS1 SOS2

2.25e-0546829182529
Pubmed

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

THBS1 LRP1

2.25e-0546827775583
Pubmed

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.

SOS1 SOS2

2.25e-05468231337738
Pubmed

SMAD2 and SMAD3 differentially regulate adiposity and the growth of subcutaneous white adipose tissue.

INHBB SMAD3

2.25e-05468234731499
Pubmed

Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1.

SOS1 SOS2

2.25e-05468210940929
Pubmed

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.

FAT1 PLXNB2 SOS1 SOS2

3.57e-059468432062451
Pubmed

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.

SOS1 SOS2

3.75e-0556829030684
Pubmed

An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells.

INHBB SMAD3

3.75e-05568218826955
Pubmed

A Regulatory Network Analysis of the Importance of USP15 in Breast Cancer Metastasis and Prognosis.

USP15 SMAD3

3.75e-05568236213818
Pubmed

A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

SOS1 SOS2

3.75e-05568223209318
Pubmed

USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

USP15 SMAD3

3.75e-05568221947082
Pubmed

Tagging genes with cassette-exchange sites.

NPL RANBP17 NSF AKAP13 PUM1 ZNF292

5.06e-0533568615741177
Pubmed

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties.

SOS1 SOS2

5.62e-05668210675333
Pubmed

LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation.

LRP1 SMAD3

5.62e-05668231023188
Pubmed

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

SOS1 SOS2

5.62e-05668214764585
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

AKAP13 SOS1 SOS2

5.74e-053868311756498
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

THBS1 MYL5 LRP1 RNF213 DNAH5

6.40e-0521468522199357
Pubmed

The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors.

DOK1 SMAD3

7.86e-05768211927552
Pubmed

Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.

SOS1 SOS2

7.86e-05768215173068
Pubmed

Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.

SOS1 SOS2

7.86e-05768230720883
Pubmed

Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively.

SOS1 SOS2

7.86e-0576828276400
Pubmed

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma.

SOS1 SOS2

7.86e-05768215953601
Pubmed

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

AKAP13 SOS1 SOS2

8.34e-054368312376548
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

THBS1 LRP1 AHSG

8.94e-054468331273033
Pubmed

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

SOS1 SOS2

1.05e-04868223452850
Pubmed

Germline gain-of-function mutations in SOS1 cause Noonan syndrome.

SOS1 SOS2

1.05e-04868217143285
Pubmed

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

USP15 SMAD3

1.05e-04868226455393
Pubmed

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma.

USP15 SMAD3

1.05e-04868222344298
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

THBS1 FAT1 LRP1 RNF213 DNAJC1 SSR1 ITGA2 PLXNB2 USP15 TFRC

1.09e-041201681035696571
Pubmed

MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

SOS1 SOS2

1.34e-04968219289468
Pubmed

B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins.

SOS1 SOS2

1.34e-0496828943292
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

LRP1 SLC1A3 TFRC

1.48e-045268326590417
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

THBS1 PTPRM LRP1 AHSG TFRC

1.51e-0425768516335952
Pubmed

USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.

SPTAN1 PC

1.68e-041068236653359
Pubmed

Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy.

ITGA2 PLXNB2 TFRC

1.74e-045568338945485
Pubmed

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.

THBS1 SMAD3

2.05e-041168238678560
Pubmed

Homeobox genes and connective tissue patterning.

SOS1 SOS2

2.05e-04116827720577
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

FAT1 PTPRM NSF DYNC2H1 MCM3AP RNF213 SCAMP3 PC ATP8B2

2.17e-04106168933845483
Pubmed

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

AKAP13 SOS1 SOS2

2.26e-046068312787561
Pubmed

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.

SOS1 SOS2

2.45e-041268215728722
Pubmed

The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.

SLC1A3 NIN

2.45e-041268222031545
Pubmed

The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.

DYNC2H1 DNAH5

2.90e-041368217884984
Pubmed

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

SNX18 USP15

2.90e-041368223146885
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

CTNNAL1 SCAMP3 DNAJC1 SSR1 SLC1A3 TFRC

3.07e-0446768630194290
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DYNC2H1 DNAH5

3.38e-04146829373155
Pubmed

Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.

THBS1 SCN7A

3.38e-04146827590978
Pubmed

Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells.

INHBB SMAD3

3.38e-041468215277382
Pubmed

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

FAT1 PLXNB2 TFRC

3.41e-046968326792178
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THBS1 LRP1 ZNF292

3.71e-047168333541421
Pubmed

Noonan Syndrome

SOS1 SOS2

3.89e-041568220301303
Pubmed

A genome-wide association study on obesity and obesity-related traits.

FAT1 INHBB

3.89e-041568221552555
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

THOC1 NSF DYNC2H1 SPTAN1 SCAMP3 SSR1 PUM1 PC DNAH5 TFRC

4.31e-041425681030948266
Pubmed

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.

USP15 TG

4.44e-041668238750011
Pubmed

Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon.

FMOD SMAD3

4.44e-041668221939397
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

ASB16 AHSG SMAD3 SOS1 SOS2

4.70e-0432968517474147
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

SPTAN1 SSR1 PC TFRC SOS1

4.97e-0433368532665550
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

THOC1 UBAP2 SPTAN1 SNX18 AKAP13 PUM1 ZNF292

5.31e-0472468736232890
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

THOC1 SPTAN1 SCAMP3 SCAF4 TFRC

5.46e-0434068524332808
Pubmed

The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.

DOK1 SOS1 SOS2

5.47e-048168320697350
Pubmed

Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.

SOS1 SOS2

5.65e-041868219531499
Pubmed

Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.

PKLR TFRC

5.65e-041868222566683
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AKAP13 SOS1 SOS2

5.17e-0466433722
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CACNA1D DLC1 PTPRM LRP1 PUM1 SMAD3

3.95e-071856861d874608aa2062024323512f68889219471b2f00
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_monocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NPL THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

5.54e-0719668689ff93cbfbe39fbdf2498e8fdc5d61a0ecb26fc9
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NPL THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

5.54e-0719668609574bfeb1d3da53b5471cfb0602946d328b3b5c
ToppCellmyeloid-Monocyte|myeloid / Lineage, cell class and subclass

NPL THBS1 SNX18 LRP1 MPEG1 PLXNB2

5.70e-071976866acf059cee6ba6bdeacc089b090d72336790972a
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

LRP1 MPEG1 RNF213 AKAP13 USP15 SMAD3

5.87e-0719868661ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CTNNAL1 DLC1 PTPRM SPTAN1 RNF213 NIN

6.23e-07200686dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellmild-Myeloid-CD14_Monocytes_3|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

5.40e-06165685a6547bb2c9c40b4878325da19b9def0ef644fa25
ToppCelldroplet-Spleen-SPLEEN-30m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM LRP1 MPEG1 PLXNB2 SLC1A3

7.81e-061786856c1b5087581ca8cea976d89ea6f34088c8fc3668
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

CACNA1D THBS1 TRABD2B LRP1 SLC1A3

8.69e-06182685ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THBS1 FMOD ZFHX4 SCN7A LRP1

9.66e-061866857582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

CACNA1D THBS1 TRABD2B SCN7A ITGA2

9.91e-06187685e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 PLXNB2 USP15 TFRC

1.07e-0519068518c020ca9a23399214133ec255ab870e0060f2e1
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D TRABD2B LRP1 SLC1A3 SMAD3

1.10e-0519168514057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 FMOD ZFHX4 SCN7A LRP1

1.13e-0519268511088878043a6ff95ba1970361256a82e434b80a
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 PLXNB2 USP15

1.15e-051936851db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NPL THBS1 LRP1 MPEG1 PLXNB2

1.15e-0519368552f5b0fbb8ca706206c65e7edbb1ddbd380aebae
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

NPL THBS1 LRP1 MPEG1 SLC1A3

1.15e-0519368531c0978ba78c9516d498aec0798902e57555e557
ToppCellLV-14._Fibroblast_III|LV / Chamber and Cluster_Paper

THBS1 FAT1 TRABD2B SMAD3 TFRC

1.18e-05194685927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CACNA1D FMOD SCN7A LRP1 SLC1A3

1.18e-051946858c37bedb23285735ff3828db3889897fada8c95d
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 PLXNB2 USP15

1.18e-05194685a94f9f7179a5733e3c378ff8b337e288785433a1
ToppCellRA-08._Macrophage|RA / Chamber and Cluster_Paper

NPL THBS1 SLC1A3 TFRC TG

1.18e-05194685ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 FMOD ZFHX4 LRP1 SLC1A3

1.21e-05195685d2c9c58b46bf96f9a536e177b995e340b55c6750
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_macrophage|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

1.21e-051956854e9513a7ea69fa9fc8e9ff2da8ef3f44e8fdc70d
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

1.21e-05195685a25a342380e258b784227f7298f609ccaa1f9ce7
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 ZFHX4 LRP1 DNAH5 SLC1A3

1.24e-051966856bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT1 ZFHX4 LRP1 DNAH5 SLC1A3

1.24e-05196685c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellCOVID-19_Moderate-Non-classical_Monocyte|COVID-19_Moderate / disease group, cell group and cell class

NPL SNX18 LRP1 MPEG1 PLXNB2

1.24e-05196685256c557fa11414c9d2cbb1fcff33f482ee1c78ac
ToppCell(7)_Monocyte|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

NPL THBS1 LRP1 MPEG1 SLC1A3

1.24e-051966850232167559dcd2d86ee8b78017cf5f2a084b2cb7
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CACNA1D DLC1 SCN7A LRP1 SLC1A3

1.24e-051966851450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TRABD2B DLC1 ZFHX4 LRP1 SLC1A3

1.27e-051976855afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TRABD2B DLC1 ZFHX4 LRP1 SLC1A3

1.27e-051976851baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

TRABD2B DLC1 ZFHX4 LRP1 SLC1A3

1.27e-05197685b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1D THBS1 SCN7A LRP1 ITGA2

1.31e-051986853ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CACNA1D DLC1 SCN7A LRP1 SLC1A3

1.31e-0519868517dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell3'_v3-lymph-node_spleen-Myeloid_Monocytic-Classical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue

NPL THBS1 LRP1 MPEG1 PLXNB2

1.31e-05198685187a04d498f0b355cb11c81172721698818082d6
ToppCell3'_v3-lymph-node_spleen-Myeloid_Monocytic|lymph-node_spleen / Manually curated celltypes from each tissue

NPL THBS1 LRP1 MPEG1 PLXNB2

1.31e-05198685065c8a9655d19f93dfdb453c78bbfe7d857caf3e
ToppCellmLN-(4)_Monocyte|mLN / shred on region, Cell_type, and subtype

NPL THBS1 LRP1 PLXNB2 SLC1A3

1.34e-051996856795ff31f92580195c9db776951f99d647484d24
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

1.34e-051996857dde5c02fcae64cd2d68f607500f2a46b97851fd
ToppCellmLN-Monocyte|mLN / Region, Cell class and subclass

NPL THBS1 LRP1 PLXNB2 SLC1A3

1.34e-05199685241f790cd5d8a9b2451333deecc826a673bae70a
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CACNA1D THBS1 DYNC2H1 LRP1 SLC1A3

1.34e-05199685a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NPL THBS1 LRP1 MPEG1 SLC1A3

1.34e-051996850f3ce61bbae69f7e333ed8dacf7257645624e163
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NPL LRP1 MPEG1 PLXNB2 SLC1A3

1.34e-0519968597af159fa3a5533ec3d45331fb80c6da8a715aa5
ToppCellmLN-Monocyte-Monocyte|mLN / Region, Cell class and subclass

NPL THBS1 LRP1 PLXNB2 SLC1A3

1.34e-05199685dcee372774c169a3048bdaed3734b3215bf8ffad
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CACNA1D THBS1 DYNC2H1 LRP1 SLC1A3

1.34e-0519968530d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 PLXNB2 SLC1A3

1.34e-0519968584879280851380e5bfe6bd48b6bbf57aedf6e003
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NPL THBS1 MPEG1 AKAP13 TFRC

1.34e-05199685667b8b47a5b388506e3177b46747267fad8024f6
ToppCellmLN-(4)_Monocyte-(40)_Monocyte|mLN / shred on region, Cell_type, and subtype

NPL THBS1 LRP1 PLXNB2 SLC1A3

1.34e-05199685bcbb1eee8d79bf670dbe113094c3a292b135ce2f
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CTNNAL1 DLC1 PTPRM SPTAN1 RNF213

1.37e-0520068572ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CACNA1D THBS1 DYNC2H1 LRP1 SLC1A3

1.37e-052006859b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FAT1 CTNNAL1 RNF213 SLC35G2 SLC1A3

1.37e-052006853a954d9d542e52c9b181f0850a09b1bff0a0c82d
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

CTNNAL1 DLC1 PTPRM SPTAN1 RNF213

1.37e-05200685edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CTNNAL1 DLC1 PTPRM SPTAN1 RNF213

1.37e-052006855c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

THBS1 LRP1 AKAP13 SSR1 USP15

1.37e-05200685e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

CTNNAL1 DLC1 PTPRM SPTAN1 ITGA2

1.37e-052006853b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NPL LRP1 MPEG1 SLC1A3 TFRC

1.37e-0520068577a68e8fd97a3f3467d25032067fd7ad52ab8522
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

CACNA1D THBS1 DYNC2H1 LRP1 SLC1A3

1.37e-05200685a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1D THBS1 SCN7A LRP1 ITGA2

1.37e-0520068534f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2B DYNC2H1 SCN7A ITGA2

6.62e-051426845b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

PTPRM SCN7A RNF213 ITGA2

1.13e-04163684d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCellfacs-Marrow-T_cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM LRP1 MPEG1 PLXNB2

1.13e-0416368430cd95d4f37bd54c1fde54960cb005db58bdd30c
ToppCellfacs-Marrow-T_cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM LRP1 MPEG1 PLXNB2

1.13e-04163684ab934cb986495adfc8dbe5a276577f2a8fb6ee03
ToppCellBAL-Severe-cDC_8|Severe / Compartment, Disease Groups and Clusters

CDAN1 THBS1 ZFHX4 THAP9

1.16e-04164684e8cbe7e01eca32886eb44e02d5333056b6bebc50
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

TRABD2B DLC1 SCN7A ITGA2

1.18e-041656846ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

NPL LRP1 MPEG1 SLC1A3

1.21e-04166684be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCell(2)_MNPs-(2)_Mono_macro|(2)_MNPs / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NPL THBS1 LRP1

1.29e-0464683494f500ccceeedf45b4ded919b237a7fb75827c4
ToppCellLV-16._Neuronal|LV / Chamber and Cluster_Paper

TRABD2B DLC1 SCN7A ITGA2

1.30e-04169684a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKLR LRP1 MPEG1 PLXNB2

1.33e-041706847cb7ad9ab064b6ea452545d145e5b1d4090cd4c1
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKLR LRP1 MPEG1 PLXNB2

1.33e-04170684db7cee7e518debb2cbe9eeae05d47e14b69cb8e3
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 RNF213 SLC1A7 TFRC

1.39e-04172684c8ea80042faf923b08ff03d73100533d521d73ef
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM LRP1 PLXNB2 SLC1A3

1.55e-0417768426bad614560609d318bfc9c235a698bca4e1c22c
ToppCelldroplet-Spleen-nan-24m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPL LRP1 MPEG1 PLXNB2

1.55e-041776845f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOK1 THBS1 FMOD LRP1

1.55e-0417768468f1139fc378f351e3b9e9f392aacb150025bf03
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPL LRP1 MPEG1 PLXNB2

1.58e-04178684be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCellwk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TRABD2B ATP8B2 SMAD3 NIN

1.58e-04178684a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D DYNC2H1 SCN7A ITGA2

1.62e-04179684666072c0e8448dbaec1683d18368ec2502453f90
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D LRP1 SLC1A3 SMAD3

1.65e-0418068408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D SNX18 MPEG1 TFRC

1.65e-04180684bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellfacs-Marrow-B-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D SNX18 MPEG1 TFRC

1.65e-04180684839defb40f7cfb2711e9025194de636533f51bcd
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTNNAL1 SCN7A DNAJC1 ITGA2

1.65e-04180684b294f9db1e2ff51c94cde64fae4c2b057c0030a1
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D SNX18 MPEG1 TFRC

1.65e-0418068482965ed1b72a1873c24dd4553d39681596057316
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D LRP1 SLC1A3 SMAD3

1.65e-041806849b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 FMOD SCN7A SLC35G2

1.69e-04181684c26d3cbbc592299786d79d1b15fc6bead2aafb9a
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

SPTAN1 RNF213 USP15 TFRC

1.69e-04181684f2315414e714ac86211546a935660c4be6e85f1b
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FMOD ZFHX4 SCN7A LRP1

1.72e-041826843dfa9187e9d2bab1d199079d29209c4648220ada
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 SCN7A LRP1 SLC1A3

1.72e-04182684f4b74c2756989812abe4e7055ec8918f69d56025
ToppCell5'-Adult-LymphNode-Hematopoietic-Myeloid-Monocytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NPL THBS1 MPEG1 SLC1A3

1.72e-041826841fb9bdf2e9f0a9c230f109b471672f9c31e27c82
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

PTPRM SCN7A RNF213 ITGA2

1.72e-041826847af3b2029b7f55b923d5a4b764d4292f4ea48599
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ZFHX4 SCN7A ITGA2 SLC1A3

1.72e-041826847b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCellE18.5-samps-Endothelial|E18.5-samps / Age Group, Lineage, Cell class and subclass

PTPRM SCN7A RNF213 ITGA2

1.72e-04182684e2d799e6e7526176a6fe6515b8fbe4d83d3a3ea1
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D TRABD2B LRP1 SMAD3

1.76e-041836847eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellFetal_29-31_weeks-Immune-enucleated_erythrocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NPL USP15 SCAF4 TFRC

1.83e-04185684e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRABD2B ZFHX4 LRP1 SMAD3

1.83e-041856843b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNF213 USP15 SMAD3 TFRC

1.83e-04185684a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THBS1 FAT1 TRABD2B SMAD3

1.83e-04185684e58a009aaf342be019a909747b1895d5987d4daf
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 SCN7A LRP1 SLC1A3

1.87e-0418668435c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THBS1 LRP1 MPEG1 USP15

1.87e-0418668423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell10x5'-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

THBS1 LRP1 PLXNB2 SLC1A3

1.87e-04186684a16ecf70271894a842925f232009e2623d16947e
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 SCN7A LRP1 SLC1A3

1.87e-04186684d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCellsevere_influenza-RBC|World / disease group, cell group and cell class (v2)

FAT1 CTNNAL1 PKLR TFRC

1.91e-04187684f846750575f318503d21ade30f5bfd2e1d4c84af
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DYNC2H1 SCN7A ITGA2 SMAD3

1.91e-04187684f124d2c699b717b7c02a1a70493f515b83dc2f4c
DrugCephalosporanic acid, 7-amino [957-68-6]; Up 200; 14.6uM; HL60; HT_HG-U133A

THBS1 SPTAN1 MCM3AP SLC1A3 SLC1A7 SMAD3 SOS2

1.96e-061996771322_UP
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A

THBS1 FAT1 MCM3AP ITGA2 PLXNB2 TFRC

6.40e-061556766817_DN
DrugEthaverine hydrochloride [985-13-7]; Up 200; 9.2uM; HL60; HT_HG-U133A

THBS1 MCM3AP LRP1 SLC35G2 SLC1A7 SMAD3

1.87e-051876763037_UP
DrugBetamethasone [378-44-9]; Up 200; 10.2uM; PC3; HT_HG-U133A

THBS1 FMOD SPTAN1 MCM3AP PKLR SLC1A7

2.16e-051926766728_UP
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; PC3; HT_HG-U133A

SCN11A THBS1 FMOD AKAP13 ATP8B2 SOS2

2.30e-051946764320_DN
DrugOrlistat; Up 200; 10uM; MCF7; HT_HG-U133A

THBS1 DLC1 SPTAN1 PKLR SLC1A7 SMAD3

2.36e-051956766415_UP
DrugMolindone hydrochloride [15622-65-8]; Up 200; 12.8uM; MCF7; HT_HG-U133A

DLC1 ZFHX4 MCM3AP SLC1A7 SOS1 SOS2

2.43e-051966764784_UP
DrugBretylium tosylate [61-75-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

CACNA1D INHBB ITGA2 PC SLC1A7 FHIP2B

2.43e-051966765020_DN
DrugStreptomycin sulfate [3810-74-0]; Up 200; 2.8uM; MCF7; HT_HG-U133A

SCN11A DLC1 ZFHX4 DYNC2H1 THAP9 ATP8B2

2.50e-051976763195_UP
DrugProcainamide hydrochloride [614-39-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

DOK1 THBS1 SPTAN1 MCM3AP AHSG SOS2

2.50e-051976762618_UP
Drugkryptofix 221

NSF PKLR

2.55e-053672CID000123438
DrugOxprenolol hydrochloride [6452-73-9]; Up 200; 13.2uM; HL60; HT_HG-U133A

THBS1 PER3 LRP1 AHSG THAP9 SMAD3

2.57e-051986766145_UP
DrugSulfasalazine [599-79-1]; Up 200; 10uM; MCF7; HT_HG-U133A

SCN11A THBS1 DLC1 ZFHX4 AHSG SOS2

2.65e-051996762882_UP
DrugDelsoline [509-18-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

PER3 AKAP13 ATP8B2 SLC1A7 SMAD3 ZNF292

2.65e-051996766075_DN
Drugirinotecan

THBS1 DLC1 NSF SNX18 SCAMP3 EIF2AK4 ITGA2 SMAD3 SCAF4 TFRC

3.74e-057036710ctd:C051890
Drugbismuth complex

ITGA2 TFRC

1.27e-046672CID000457407
Drugbromoacetone

ITGA2 PC

1.27e-046672CID000011715
Drugirinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A

ZFHX4 AKAP13 PUM1 SMAD3 SOS2

1.49e-041716757535_DN
Drugsilver nanoparticles

NPL ITGA2 NLRP4 SLC1A3 TFRC

1.54e-04172675CID000023954
Drug2-benzoylpyridine

ITGA2 DNAH5

1.77e-047672CID000007038
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

DOK1 LRP1 AKAP13 ITGA2 PUM1

2.21e-041866754463_UP
Drugn-C4H9

ITGA2 NLRP4

2.36e-048672CID000137616
Drugaspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A

MYL5 VPS8 AKAP13 SCAF4 SOS2

2.56e-041926756164_DN
DrugForskolin, from Coleus forskohlii; Down 200; 0.5uM; PC3; HT_HG-U133A

INHBB SPTAN1 AKAP13 USP15 SMAD3

2.56e-041926757104_DN
DrugDihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A

THOC1 CACNA1D PTPRM SMAD3 SOS2

2.56e-041926754152_DN
DrugTerbutaline hemisulfate [23031-32-5]; Down 200; 7.2uM; PC3; HT_HG-U133A

SCN11A THBS1 MYL5 PER3 SMAD3

2.62e-041936755764_DN
DrugDilazep dihydrochloride [20153-98-4]; Down 200; 6uM; MCF7; HT_HG-U133A

DOK1 PER3 SPTAN1 MCM3AP SCAF4

2.62e-041936752294_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; MCF7; HT_HG-U133A

MCM3AP SSR1 ATP8B2 SCAF4 SOS2

2.62e-041936754406_DN
DrugDiflorasone Diacetate [33564-31-7]; Down 200; 8uM; HL60; HT_HG-U133A

MYL5 ITGA2 ATP8B2 SLC1A7 SMAD3

2.62e-041936752142_DN
DrugIopamidol [60166-93-0]; Up 200; 5.2uM; MCF7; HT_HG-U133A

NPL PER3 SPTAN1 MCM3AP SOS2

2.68e-041946757189_UP
DrugCefixime [79350-37-1]; Down 200; 8.8uM; HL60; HT_HG-U133A

MYL5 DYNC2H1 DNAJC1 ITGA2 SOS1

2.68e-041946751310_DN
DrugFenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A

NPL AKAP13 ATP8B2 SMAD3 SOS2

2.75e-041956757432_DN
Drugradicicol; Down 200; 0.1uM; MCF7; HG-U133A

DNAJC1 SMAD3 TFRC TG SOS2

2.75e-04195675489_DN
DrugSulfamerazine [127-79-7]; Down 200; 15.2uM; MCF7; HT_HG-U133A

ADPRM DLC1 MCM3AP ATP8B2 SOS2

2.75e-041956754740_DN
DrugEthisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ADPRM SPTAN1 MCM3AP SMAD3 ZNF292

2.75e-041956753864_DN
DrugCefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A

NPL SPTAN1 AKAP13 SMAD3 SOS2

2.81e-041966757186_UP
DrugMoricizine hydrochloride [31883-05-3]; Down 200; 8.6uM; PC3; HT_HG-U133A

MYL5 AKAP13 PC USP15 ZNF292

2.81e-041966757297_DN
DrugHeliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A

DOK1 CACNA1D DLC1 PER3 SLC1A7

2.81e-041966754739_DN
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

DOK1 ZFHX4 AKAP13 SMAD3 SOS2

2.81e-041966755236_UP
DrugButamben [94-25-7]; Down 200; 20.6uM; HL60; HT_HG-U133A

RANBP17 THBS1 SLC1A7 SMAD3 SOS2

2.81e-041966752531_DN
DrugTrimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; HL60; HT_HG-U133A

ZFHX4 DYNC2H1 AKAP13 DNAJC1 SMAD3

2.81e-041966752736_DN
DrugSulfadimethoxine [122-11-2]; Up 200; 12.8uM; MCF7; HT_HG-U133A

FMOD MYL5 SLC1A7 ZNF292 SOS2

2.81e-041966753441_UP
DrugNefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; HL60; HT_HG-U133A

ADPRM DYNC2H1 MCM3AP SMAD3 SOS1

2.81e-041966752355_UP
Druggenistein; Up 200; 10uM; HL60; HT_HG-U133A

THBS1 MCM3AP DNAJC1 SLC1A7 SMAD3

2.81e-041966756194_UP
DrugMetoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Down 200; 5.8uM; MCF7; HT_HG-U133A

CACNA1D THBS1 THAP9 SLC1A7 SOS2

2.88e-041976756106_DN
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A

THBS1 DLC1 AKAP13 SLC1A7 SCAF4

2.88e-041976755276_UP
DrugAconitine [302-27-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A

CACNA1D ADPRM MYL5 SMAD3 SOS2

2.88e-041976756797_DN
DrugCytisine (-) [485-35-8]; Down 200; 21uM; MCF7; HT_HG-U133A

DYNC2H1 SPTAN1 AKAP13 SCAF4 SOS1

2.88e-041976756217_DN
DrugEpirizole [18694-40-1]; Down 200; 17uM; PC3; HT_HG-U133A

MYL5 AKAP13 PC ATP8B2 FHIP2B

2.88e-041976751803_DN
DrugPropoxycaine hydrochloride [550-83-4]; Up 200; 12uM; HL60; HT_HG-U133A

THBS1 DLC1 PER3 ZFHX4 MCM3AP

2.88e-041976756161_UP
DrugTubocurarine chloride pentahydrate (+) [6989-98-6]; Down 200; 5.2uM; MCF7; HT_HG-U133A

DOK1 MYL5 SPTAN1 ATP8B2 SMAD3

2.88e-041976752887_DN
DrugCefixime [79350-37-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A

THBS1 AKAP13 ATP8B2 SMAD3 SCAF4

2.88e-041976753247_DN
Drug2-propylpentanoic acid; Down 200; 50uM; PC3; HT_HG-U133A

RANBP17 AKAP13 DNAJC1 SMAD3 SCAF4

2.88e-041976751222_DN
DrugLY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A

ADPRM FMOD AKAP13 ITGA2 ATP8B2

2.88e-041976751641_UP
Drugnovobiocin sodium, USP; Down 200; 100uM; PC3; HG-U133A

RANBP17 LRP1 PLXNB2 SMAD3 TG

2.88e-04197675435_DN
DrugGuanethidine sulfate [60-02-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A

CACNA1D MCM3AP SLC1A7 SMAD3 SCAF4

2.88e-041976753171_DN
DrugBenserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A

AKAP13 ITGA2 USP15 SCAF4 SOS1

2.88e-041976755322_DN
DrugGlutethimide, para-amino [125-84-8]; Down 200; 17.2uM; MCF7; HT_HG-U133A

NPL THBS1 MCM3AP SMAD3 SOS2

2.88e-041976757463_DN
DrugTranexamic acid [1197-18-8]; Up 200; 25.4uM; MCF7; HT_HG-U133A

DOK1 SCN11A ZFHX4 TG SOS2

2.88e-041976752248_UP
DrugAconitine [302-27-2]; Up 200; 6.2uM; MCF7; HT_HG-U133A

DOK1 CACNA1D PER3 AHSG SLC1A7

2.88e-041976756797_UP
DrugReserpinic acid hydrochloride; Down 200; 9.2uM; PC3; HT_HG-U133A

THBS1 LRP1 AKAP13 PC SOS2

2.95e-041986756603_DN
DrugPhenindione [83-12-5]; Down 200; 18uM; MCF7; HT_HG-U133A

AKAP13 SMAD3 SCAF4 ZNF292 SOS2

2.95e-041986755991_DN
DrugThyroxine (L) [51-48-9]; Down 200; 5.2uM; MCF7; HT_HG-U133A

CACNA1D FMOD DLC1 PTPRM SOS2

2.95e-041986754150_DN
DrugOxethazaine [126-27-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A

THBS1 DLC1 SMAD3 TG SOS2

2.95e-041986751484_UP
DrugMeclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A

CACNA1D THBS1 AKAP13 SMAD3 SOS2

2.95e-041986754729_DN
DrugClorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A

CACNA1D DYNC2H1 MCM3AP ZNF292 SOS2

2.95e-041986753219_DN
DrugBetulinic acid [472-15-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A

CACNA1D THBS1 ATP8B2 SLC1A7 SOS2

2.95e-041986753281_DN
DrugPargyline hydrochloride [306-07-0]; Down 200; 20.4uM; MCF7; HT_HG-U133A

MYL5 DYNC2H1 AKAP13 ATP8B2 SOS2

2.95e-041986757016_DN
DrugCimetidine [51481-61-9]; Up 200; 15.8uM; MCF7; HT_HG-U133A

SCN11A ADPRM FMOD MCM3AP SOS2

2.95e-041986751464_UP
DrugCatechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; HL60; HT_HG-U133A

RANBP17 DLC1 SPTAN1 ATP8B2 SMAD3

2.95e-041986753012_DN
DrugPicrotoxinin [17617-45-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A

DYNC2H1 MCM3AP FHIP2B SCAF4 SOS2

2.95e-041986752816_DN
DrugMethyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; PC3; HT_HG-U133A

DOK1 CACNA1D FMOD SLC1A7 SOS2

2.95e-041986756640_UP
DrugHydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; MCF7; HT_HG-U133A

ADPRM PER3 SPTAN1 MCM3AP SLC1A7

3.02e-041996755006_DN
DrugPropranolol hydrochloride [318-98-9]; Up 200; 13.6uM; MCF7; HT_HG-U133A

DOK1 DLC1 ZFHX4 SLC1A7 SMAD3

3.02e-041996755358_UP
DrugNalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A

SCN11A PER3 SPTAN1 SLC1A7 TG

3.02e-041996757367_UP
DrugCefoxitin sodium salt [33564-30-6]; Down 200; 8.8uM; PC3; HT_HG-U133A

ADPRM DLC1 ATP8B2 SCAF4 SOS2

3.02e-041996757148_DN
DrugAdamantamine fumarate [80789-67-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

SPTAN1 ATP8B2 SLC1A7 SMAD3 ZNF292

3.02e-041996754806_DN
Drughaloperidol; Up 200; 10uM; HL60; HT_HG-U133A

RANBP17 SCN11A SPTAN1 DNAJC1 SOS1

3.02e-041996751185_UP
Drug5-aza-2′-deoxycytidine; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

RANBP17 ADPRM DLC1 DYNC2H1 ITGA2

3.02e-04199675920_DN
DrugClorsulon [60200-06-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

RANBP17 DYNC2H1 ITGA2 SMAD3 SOS2

3.02e-041996757025_DN
DrugVincamine [1617-90-9]; Up 200; 11.2uM; HL60; HT_HG-U133A

DLC1 PER3 DNAJC1 FHIP2B SOS1

3.02e-041996752367_UP
DrugAC1N7H7A

NPL TG

3.03e-049672CID004302459
DrugHesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A

DOK1 THBS1 DLC1 SPTAN1 MCM3AP

3.09e-042006752648_UP
DrugNaringin hydrate [11032-30-7]; Up 200; 6.6uM; PC3; HT_HG-U133A

SCN11A OR1A2 AKAP13 SLC1A7 SCAF4

3.09e-042006754605_UP
Diseaseepilepsy (implicated_via_orthology)

SCN11A NSF SCN7A LRP1 SLC1A3 SLC1A7

1.63e-06163656DOID:1826 (implicated_via_orthology)
Diseasepulse pressure measurement

CACNA1D DLC1 ZFHX4 DYNC2H1 LRP1 RNF213 AKAP13 EIF2AK4 PLXNB2 SMAD3 NIN SOS2

4.58e-0513926512EFO_0005763
Diseaseepisodic ataxia type 6 (implicated_via_orthology)

SLC1A3 SLC1A7

7.13e-056652DOID:0050994 (implicated_via_orthology)
DiseaseColorectal Carcinoma

FAT1 DLC1 MCM3AP LRP1 SLC1A7 SMAD3 ZNF292 TFRC

1.51e-04702658C0009402
DiseaseAbnormality of the face

PUM1 ZNF292

1.70e-049652C4025871
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN11A SCN7A

2.13e-0410652DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN11A SCN7A

2.13e-0410652DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN11A SCN7A

3.11e-0412652DOID:0060170 (implicated_via_orthology)
DiseaseColorectal Neoplasms

FAT1 DLC1 SMAD3 ZNF292 TFRC

3.67e-04277655C0009404
DiseaseHeadache

LRP1 RNF213 SOS1

3.86e-0464653HP_0002315
Diseasecerebellum cortex volume change measurement

PTPRM TFRC

4.27e-0414652EFO_0021497
Diseasetype 2 diabetes mellitus (is_implicated_in)

CACNA1D PKLR AHSG ITGA2

5.60e-04171654DOID:9352 (is_implicated_in)
Diseaseasthma, endometriosis

DNAJC1 PLXNB2 SMAD3

5.91e-0474653EFO_0001065, MONDO_0004979
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

SOS1 SOS2

7.98e-0419652C3501846
DiseaseCostello syndrome (disorder)

SOS1 SOS2

7.98e-0419652C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

SOS1 SOS2

7.98e-0419652C1843181
DiseaseCardio-facio-cutaneous syndrome

SOS1 SOS2

7.98e-0419652C1275081
Diseaseintraocular pressure measurement

DLC1 NSF DYNC2H1 AKAP13 SMAD3 SOS2

8.94e-04509656EFO_0004695
Diseasemigraine disorder, Headache

NSF LRP1 RNF213

9.16e-0486653HP_0002315, MONDO_0005277
DiseaseLEOPARD Syndrome

SOS1 SOS2

1.07e-0322652C0175704
DiseaseCalcium channel blocker use measurement

CACNA1D FAT1 RNF213 SOS2

1.27e-03213654EFO_0009930
DiseaseNoonan Syndrome

SOS1 SOS2

1.28e-0324652C0028326
DiseaseFEV/FEC ratio

CACNA1D DLC1 PTPRM LRP1 MYRFL DNAH5 SLC1A3 SMAD3 TG

1.43e-031228659EFO_0004713
Diseasemigraine disorder, pulse pressure measurement

DYNC2H1 LRP1

1.50e-0326652EFO_0005763, MONDO_0005277
Diseaselumbar disc degeneration

DYNC2H1 SMAD3

1.74e-0328652EFO_0004994
Diseasecorneal topography

AKAP13 EIF2AK4 SMAD3

1.81e-03109653EFO_0004345

Protein segments in the cluster

PeptideGeneStartEntry
VQQHNGIIFQFVAFI

EIF2AK4

1321

Q9P2K8
QFLATSAGNQQALNF

AKAP13

101

Q12802
FSGNLQQVQALFQDE

ASB16

66

Q96NS5
QFVQFNGGFSQEQLN

ADPRM

206

Q3LIE5
EVQLNFYQFLGVQQD

DNAJC1

61

Q96KC8
QTSQGLQAQLAQAFF

CDAN1

841

Q8IWY9
QQNINIFSQDLFGQT

ANKRD19P

221

Q9H560
FPNQFRFVGNAQNTL

ATP8B2

1066

P98198
AFETVLQIFNNNFKQ

RANBP17

696

Q9H2T7
GLAFQNTVNFKFEEN

MPEG1

241

Q2M385
QFTINFNTGVINVIA

FAT1

2226

Q14517
GVTSQQEQNNVFFVI

OR1A2

16

Q9Y585
YFQNNQITSIQEGVF

FMOD

111

Q06828
FFSDIHFGNIQQIND

LRP1

2256

Q07954
FFISNEGNQNLFVVQ

INHBB

161

P09529
VQAFAALNSNNFVRF

MCM3AP

841

O60318
QANSEFFQILSQNGA

PER3

91

P56645
TLQQFVDNFFQSVLA

PLXNB2

1631

O15031
QQVFQFFSKVLAQVQ

FHIP2B

106

Q86V87
SNVFSNFEQTQIQEF

MYL5

21

Q02045
ENEALQQFFEAQGAN

MYRFL

6

Q96LU7
QLTQELGTAFFQQQQ

PKLR

46

P30613
NNQAFSVGQQLVFSF

NSF

126

P46459
DAFFGFQLSQEIKQQ

NLRP4

516

Q96MN2
EQQVTFTINFDFNLQ

ITGA2

886

P17301
FTINFDFNLQNLQNQ

ITGA2

891

P17301
NNIFFEFFIQNDQCQ

ELAPOR2

211

A8MWY0
VGLFDYNSQQQLFQR

PUM1

376

Q14671
NENINQVVFVGNFLR

PANK2

511

Q9BZ23
QFFNSSVIDVFNQRN

DYNC2H1

3946

Q8NCM8
FTFQTAQGNDIFQAV

DOK1

231

Q99704
SFQEFVQIFSQFGNE

CTNNAL1

186

Q9UBT7
FIAQVNNYELDFGQI

SLC1A7

391

O00341
FNAQNNGSNFQLEEI

AHSG

171

P02765
IFIAQVNNFELNFGQ

SLC1A3

411

P43003
FAAVAQLFQTTQGQQ

SCAF4

186

O95104
FQKAQQEFAAGVFSN

SCAMP3

311

O14828
NNNFQTFPQAVLLLF

CACNA1D

1386

Q01668
EFNQADFNATVQFIQ

DNAH5

4211

Q8TE73
IQNVEVNAGQFATFQ

PTPRM

191

P28827
LQQNIDVFSQDVFGQ

POTEA

251

Q6S8J7
VDQNRQQQFAFLFGV

NPL

186

Q9BXD5
QQQFAFLFGVDEQLL

NPL

191

Q9BXD5
ILQVFQDLNNFNGVL

SOS2

856

Q07890
NGNVFQDAVFNQTVT

SSR1

181

P43307
FGNTAEQTEQFLQQN

NIN

1116

Q8N4C6
QGAFDFAQIFSLTQQ

SCRN2

221

Q96FV2
EIGQFQSFAEKNIFQ

SLC35G2

86

Q8TBE7
FDGNQFQKAQAISAF

IFNA16

66

P05015
AFNSIFQNENFQLQL

VPS8

1406

Q8N3P4
IEILQVFQELNNFNG

SOS1

856

Q07889
PFNQSTFNNVVEQNF

DLC1

781

Q96QB1
QNNGAFNETLFRNQL

TFRC

721

P02786
ALQILQQTFFEGDQQ

RNF213

3051

Q63HN8
FETSQQQGFGQALVF

UBAP2

311

Q5T6F2
ELQQQAAFFQPQFLN

ZFHX4

1656

Q86UP3
DNFQGVLQNVRFVFG

THBS1

206

P07996
FQNFQSIQFINGIAH

THAP9

426

Q9H5L6
NGLNFSQVLFALNQT

TRABD2B

216

A6NFA1
QEFAALLAQSVNQGF

SMAD3

346

P84022
DQQAFSVGLNQAIAF

SNX18

481

Q96RF0
RAGTFQAFEQFGQQL

SPTAN1

1391

Q13813
ENAVFPSQVNVANNF

ZNF292

1316

O60281
LFTFQFNNLGNTDIN

USP15

711

Q9Y4E8
LNGLNFSQVIFALNQ

TRABD2A

216

Q86V40
QGFIFDVVTSQAFNV

SCN7A

1241

Q01118
NLFIGVIIDNFNQQQ

SCN11A

1301

Q9UI33
SFGFEINLQENQNAL

TG

551

P01266
FLQNVLNNQQFLAGT

PC

461

P11498
LNNQQFLAGTVDTQF

PC

466

P11498
NLQSQFNLENVTVFN

THOC1

176

Q96FV9