Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentextrinsic component of postsynaptic density membrane

AKAP9 TIAM1

1.51e-0410392GO:0099147
GeneOntologyCellularComponentextrinsic component of postsynaptic specialization membrane

AKAP9 TIAM1

2.21e-0412392GO:0098892
GeneOntologyCellularComponentneuron to neuron synapse

PRKN AKAP9 PLPPR4 TIAM1 RNF19A SPTBN1

3.85e-04523396GO:0098984
GeneOntologyCellularComponentglutamatergic synapse

PRKN AKAP9 PLPPR4 TIAM1 TRIO RNF19A SPTBN1

7.00e-04817397GO:0098978
GeneOntologyCellularComponentextrinsic component of postsynaptic membrane

AKAP9 TIAM1

7.65e-0422392GO:0098890
GeneOntologyCellularComponentdesmosome

EVPL DSC3

1.24e-0328392GO:0030057
GeneOntologyCellularComponentpericentriolar material

AKAP9 TIAM1

1.24e-0328392GO:0000242
GeneOntologyCellularComponentlipid droplet

SET SETSIP VPS13A

1.32e-03116393GO:0005811
GeneOntologyCellularComponentpostsynaptic density

PRKN AKAP9 PLPPR4 TIAM1 SPTBN1

1.44e-03451395GO:0014069
GeneOntologyCellularComponentasymmetric synapse

PRKN AKAP9 PLPPR4 TIAM1 SPTBN1

1.84e-03477395GO:0032279
GeneOntologyCellularComponentextrinsic component of synaptic membrane

AKAP9 TIAM1

1.94e-0335392GO:0099243
GeneOntologyCellularComponentpostsynaptic specialization

PRKN AKAP9 PLPPR4 TIAM1 SPTBN1

2.32e-03503395GO:0099572
GeneOntologyCellularComponentpostsynapse

PRKN AKAP9 PLPPR4 TIAM1 TRIO RNF19A SPTBN1

2.49e-031018397GO:0098794
GeneOntologyCellularComponentpostsynaptic density membrane

AKAP9 PLPPR4 TIAM1

3.12e-03157393GO:0098839
DomainSpectrin_repeat

EVPL TRIO SPTBN1

3.20e-0529403IPR002017
DomainSpectrin/alpha-actinin

EVPL TRIO SPTBN1

4.32e-0532403IPR018159
DomainSPEC

EVPL TRIO SPTBN1

4.32e-0532403SM00150
DomainAIG1

GIMAP4 GIMAP8

1.24e-048402PF04548
DomainG_AIG1

GIMAP4 GIMAP8

1.24e-048402IPR006703
DomainG_AIG1

GIMAP4 GIMAP8

1.24e-048402PS51720
DomainE3_UB_ligase_RBR

PRKN RNF19A

1.99e-0410402IPR031127
DomainIBR

PRKN RNF19A

4.00e-0414402PF01485
DomainIBR

PRKN RNF19A

4.00e-0414402SM00647
DomainIBR_dom

PRKN RNF19A

4.61e-0415402IPR002867
DomainNAP

SET SETSIP

5.96e-0417402PF00956
DomainNAP_family

SET SETSIP

5.96e-0417402IPR002164
DomainSpectrin

TRIO SPTBN1

1.10e-0323402PF00435
DomainGDS_CDC24_CS

TIAM1 TRIO

3.15e-0339402IPR001331
DomainDH_1

TIAM1 TRIO

8.04e-0363402PS00741
DomainRhoGEF

TIAM1 TRIO

9.32e-0368402SM00325
PathwayPID_RAC1_REG_PATHWAY

RACGAP1 TIAM1 TRIO

5.65e-0538283M241
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

SET AKAP9 TRIO ADAMTS9 EHMT2 GPATCH2L SPTBN1

1.45e-0649740723414517
Pubmed

Barrier-to-Autointegration Factor influences specific histone modifications.

SET EHMT2

3.87e-06340222127260
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

RACGAP1 SH3PXD2B PHACTR2 AKAP9 TIAM1 TRIO CARMIL1 SPTBN1

5.21e-0686140836931259
Pubmed

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.

TIAM1 TRIO

7.73e-06440211595749
Pubmed

Distinct roles for CARMIL isoforms in cell migration.

TRIO CARMIL1

1.29e-05540219846667
Pubmed

Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.

GIMAP4 GIMAP8

1.29e-05540211964296
Pubmed

Structural insights into the mechanism of GTPase activation in the GIMAP family.

GIMAP4 GIMAP8

1.29e-05540223454188
Pubmed

14-3-3ζ negatively regulates mitochondrial biogenesis in GBM residual cells.

KATNIP AKAP9 DSC3

2.50e-054940334825085
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

AKAP9 TRIO PCNX4 SPTBN1

2.76e-0515140417043677
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

CASP8AP2 SH3PXD2B ADAMTS9 SCN3A

2.91e-0515340410718198
Pubmed

Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis.

AKAP9 CEP290

3.60e-05840224648492
Pubmed

Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.

GIMAP4 GIMAP8

3.60e-05840211814688
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

EVPL SH3PXD2B PHACTR2 DSC3 CARMIL1 SPTBN1

4.30e-0556540625468996
Pubmed

Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.

GIMAP4 GIMAP8

4.62e-05940215474311
Pubmed

IAN family critically regulates survival and development of T lymphocytes.

GIMAP4 GIMAP8

5.77e-051040216509771
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RACGAP1 SH3PXD2B AKAP9 PLPPR4 TRIO EHMT2 SPTBN1

1.02e-0496340728671696
Pubmed

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.

SET SH3PXD2B TRIO CARMIL1

1.41e-0423040435449600
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

AKAP9 DSC3 TIAM1 TRIO SPTBN1 CEP290 VPS13A

1.74e-04104940727880917
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

PRKN HERC6 RNF19A

1.81e-049540329643511
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

EVPL GIMAP8 ADAMTS9 SCN3A CEP290 VPS13A

1.83e-0473640629676528
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

RACGAP1 SET SH3PXD2B DSC3 TRIO

2.00e-0447240538943005
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SET PHACTR2 PHF20L1 SPAG17 ARMC3 SETSIP SPTBN1 VPS13A

2.01e-04144240835575683
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

CASP8AP2 AKAP9 DSC3 TIAM1 MRPL22 EHMT2 SPTBN1 VPS13A

2.48e-04148740833957083
Pubmed

Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.

RACGAP1 SH3PXD2B CARMIL1

2.65e-0410840319531213
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

RACGAP1 EVPL SPTBN1

3.43e-0411840330979931
Pubmed

Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.

TIAM1 TRIO

3.50e-042440230814219
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

AKAP9 TRIO SPTBN1

3.61e-0412040331413325
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

SH3PXD2B TRIO RNF19A SPTBN1

5.68e-0433240437433992
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

SET PHF20L1 EHMT2

6.91e-0415040328242625
Pubmed

Joubert Syndrome

KATNIP CEP290

7.07e-043440220301500
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

TIAM1 TRIO

8.83e-043840219911011
InteractionRHOB interactions

RACGAP1 PHACTR2 DSC3 TIAM1 TRIO RNF19A CARMIL1 SPTBN1 VPS13A

1.99e-05840389int:RHOB
InteractionYWHAH interactions

RACGAP1 PRKN SH3PXD2B PHACTR2 AKAP9 TIAM1 TRIO CARMIL1 SPTBN1 CEP290

2.66e-0511023810int:YWHAH
InteractionLIMS1 interactions

PRKN TRIO ADAMTS9 EHMT2

3.42e-0598384int:LIMS1
InteractionATG5 interactions

PRKN SET SH3PXD2B TIAM1 TRIO CARMIL1

4.12e-05344386int:ATG5
GeneFamilyGTPases, IMAP

GIMAP4 GIMAP8

5.54e-058262580
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 TRIO

4.03e-0366262722
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 CASP8AP2 GIMAP8 SPTBN1 VPS13A

6.01e-071824051710eab3037a87609d21838be2d2d29c3bc36651
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 CASP8AP2 GIMAP8 SPTBN1 VPS13A

6.01e-07182405e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCellCOVID-19_Moderate-MAIT|COVID-19_Moderate / disease group, cell group and cell class

EVPL PHACTR2 SPAG17 SETSIP

1.24e-051594046d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCellCOVID-19_Moderate-MAIT|World / disease group, cell group and cell class

EVPL PHACTR2 SPAG17 SETSIP

1.27e-05160404bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKN RNF19A SPTBN1 VPS13A

1.51e-0516740483969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EVPL SPAG17 DSC3 SCN3A

1.85e-051764042e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EVPL SPAG17 DSC3 SCN3A

1.98e-051794048ce5000088b727783a0619baa16a2cd036d21f54
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PLPPR4 TIAM1 CARMIL1 SPTBN1

2.71e-05194404b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-T_cells-Tfh|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 PHACTR2 TIAM1 RNF19A

2.77e-05195404ea83c3c93ec4e09029185508bdbd6d9cc5e441d5
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Tfh|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 PHACTR2 TIAM1 RNF19A

2.77e-05195404b2ecab35db438c82872cd16a6e9f013475e559ef
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PLPPR4 TIAM1 CARMIL1 SPTBN1

2.77e-051954040e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

2.82e-051964049b53e3fdb23dbdfc2e7ce012c6b2ce50700c95d5
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODAD4 AKAP9 SPAG17 ARMC3

2.88e-0519740487db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

2.88e-05197404dfc052a447c3b32235fcaffdf06c4e0941723d19
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODAD4 AKAP9 SPAG17 ARMC3

2.88e-0519740491637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODAD4 AKAP9 SPAG17 ARMC3

2.88e-0519740422c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODAD4 AKAP9 SPAG17 CEP290

2.88e-0519740474a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODAD4 AKAP9 SPAG17 ARMC3

2.88e-051974043bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

2.94e-051984044a70a1ab40fe30b90acd97e4e36067db62acc905
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

2.94e-05198404ff8a9adc1302a4679ccdfe9ef95ef53e4c7a5391
ToppCellASK428-Endothelial|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

GIMAP4 GIMAP8 ADAMTS9 SCN3A

2.94e-05198404d69d0ff115298596173a4278897a65007a71f5df
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

ODAD4 PHACTR2 AKAP9 CEP290

2.94e-0519840476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

2.94e-0519840409e452742aed9f48bf1ffc35c6b06a296bcfe076
ToppCellCaecum-(1)_T_cell-(15)_Treg|Caecum / shred on region, Cell_type, and subtype

GIMAP4 PHACTR2 TIAM1 RNF19A

3.00e-0519940412c22b07a231c9dc548e9dc37e0a60296a4a6273
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

AKAP9 SPAG17 RNF19A CEP290

3.00e-0519940461b1ed2db71b96157b92b7535d1955a4033098da
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GIMAP4 GIMAP8 TIAM1 SPTBN1

3.00e-051994045d976d57872a8a25a11fe8cd53b01aa21a1a519a
ToppCellCaecum-T_cell-Treg|Caecum / Region, Cell class and subclass

GIMAP4 PHACTR2 TIAM1 RNF19A

3.00e-05199404ab0b32c077ac26d32a293dcf686af6984980793f
ToppCellcellseq2-Endothelial-Endothelial_Vascular|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

3.05e-05200404dc244a5ccec1b793dc4371fb2cd2c3fd4226283e
ToppCellcellseq2-Endothelial|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

3.05e-0520040481bdf7a1ddc3e82b96526449e662cca26d7297b1
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EVPL AKAP9 DSC3 SPTBN1

3.05e-0520040497f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

3.05e-0520040406ffa5baad3e699cf66d8b2c7513649e1d2c7e62
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

3.05e-052004040afc7a0f87eac48f772759c3b626758089733361
ToppCellTracheal-10x5prime-Endothelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GIMAP4 GIMAP8 ADAMTS9 SPTBN1

3.05e-0520040471ba0e48ca4ded077f2b96a0cf4f2331f2e25d15
ToppCellHippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

GIMAP4 GIMAP8 ADGRE3

1.35e-041114033e38efb22c47506ef2e2c1e19c79450e11d0ce56
ToppCellHippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)--|Hippocampus / BrainAtlas - Mouse McCarroll V32

GIMAP4 GIMAP8 ADGRE3

1.35e-041114039ba3590be8862c23b6e2917caed8bdbd9f9c2753
ToppCellHippocampus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Lcn2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

GIMAP4 GIMAP8 ADGRE3

1.35e-04111403cd84f2a9102a6eb63226ecde11d4ece54ff99b48
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

RACGAP1 SETSIP ADGRE3

3.15e-041484036cd7ef4f29d9a0944f724d9d8117d4d25e517fe4
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.15e-04148403d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.15e-04148403c8e93b87212f55774223caa385859c566fa1981f
ToppCellCiliated_cells-B-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

ODAD4 SPAG17 ARMC3

3.21e-041494036399c5a2f06d79f020dece252526f1c0c110d569
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ODAD4 SPAG17 PLPPR4

3.34e-04151403633ed52dd3b4cf1e87432cf0a1ca187d7b204e83
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ODAD4 SPAG17 PLPPR4

3.34e-04151403e335dad89e0a44cdd302b9653154ba5d1ee5fe1a
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.34e-0415140381cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.34e-041514039cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GIMAP4 PHACTR2 SPTBN1

3.41e-04152403405d19b290232bb3e564d61c0cff0cfdd247bdff
ToppCellfrontal_cortex|World / Per Region, Lineage, Cell class, Cell type, Cell subtype

RACGAP1 PHACTR2 RGS13

3.41e-04152403f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GIMAP4 PHACTR2 SPTBN1

3.41e-0415240306fa7d8acc8f56de00af9bee17884595b300410e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

GIMAP4 PHACTR2 SPTBN1

3.47e-04153403b101cb1bce5db785dab46b6c4f7be9c3efe48b0e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GIMAP4 PHACTR2 SPTBN1

3.47e-04153403487388082bb596809ba1caf9197626b6814792ab
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SET ARMC3 PLPPR4

3.47e-041534035ac4b97d35c1029a5fc625239f92e35136c4d832
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tnc|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RASGEF1C HERC6 RGS13

3.54e-041544030066b2b8cfc74603e97f271ef5efc7ec512110dc
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.54e-041544037556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellCiliated_cells-A-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ODAD4 SPAG17 ARMC3

3.54e-041544033b938e23324f7edb56797b4a76fb96ff588142cf
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.54e-041544034e3bc24043144143842627cacf6f90dda2228910
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.54e-0415440358072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.54e-041544039ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RACGAP1 GIMAP4 GIMAP8

3.61e-041554031fb49b48e34e740118908951e079ea2a9994ae4f
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.61e-041554035f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ODAD4 SPAG17 ARMC3

3.61e-041554030944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RACGAP1 GIMAP4 GIMAP8

3.61e-041554034ae91bc7dbb9f713a1f110c17834b1d89f1b28db
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RACGAP1 GIMAP4 GIMAP8

3.61e-04155403fdcc8a475156329b3594d5ed22ba03538305327c
ToppCellCOVID-19_Severe-Lymphoid_T/NK-dn_T|COVID-19_Severe / Disease group, lineage and cell class

GIMAP4 PHACTR2 SPTBN1

3.68e-0415640383f25683e0f55472b56f915ee176fc05efc33a31
ToppCellControl-Lymphocyte-T_NK-dnT|Control / Disease, Lineage and Cell Type

GIMAP4 PHACTR2 SPTBN1

3.82e-041584037a2fad6426549d910834debfe5e102fe2ab5976d
ToppCellCiliated_cells-A-HP_01|World / lung cells shred on cell class, cell subclass, sample id

ODAD4 SPAG17 ARMC3

3.89e-041594030c65ae6140abd48c79b04758a6217709ddd15385
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SCN3A CEP290 VPS13A

4.03e-04161403d72c572613f8eff3251cb7b1e9dcc76d193b2f21
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs|GI_large-bowel / Manually curated celltypes from each tissue

PHACTR2 TIAM1 RNF19A

4.11e-041624039a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGEF1C GIMAP4 GIMAP8

4.18e-04163403a0315855c354e830e109d41bd6e3396488aa8de9
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGEF1C GIMAP4 GIMAP8

4.25e-04164403a59078c8f88e416e940c9b15151ce7de1bbe987e
ToppCellfacs-BAT-Fat-18m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RACGAP1 GIMAP4 GIMAP8

4.25e-04164403ab9c17f86b98e1a4d5db1bd3086edab1320ebda8
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ODAD4 SPAG17 ARMC3

4.25e-041644039e16e52f5a634585f26021bcce9b5d5992ff6db0
ToppCellT_cells-TFH-like_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

PHACTR2 TIAM1 RNF19A

4.25e-04164403b10cf59f4cc37ca6cd0ecf71d7de278cc2bdd8b5
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

RASGEF1C EVPL RGS13

4.33e-0416540393d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

ODAD4 SPAG17 ARMC3

4.33e-04165403731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

RASGEF1C EVPL RGS13

4.33e-041654035fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

ODAD4 SPAG17 PCNX4

4.49e-0416740326cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EVPL PRKN GDF2

4.49e-04167403351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EVPL PRKN GDF2

4.49e-04167403c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GIMAP8 HERC6 SPTBN1

4.64e-04169403987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RACGAP1 TIAM1 GPATCH2L

4.64e-041694034db49b7eaea34e6558ee73b01e76315e99cc880b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TIAM1 RGS13 ADGRE3

4.72e-04170403be2a34c70665d8d11332b1a70eda03d77cb7f7dd
ToppCellLV-13._Vascular_Smooth_Muscle|LV / Chamber and Cluster_Paper

ADAMTS9 CARMIL1 SCN3A

4.81e-04171403e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell3'_v3-blood-Lymphocytic_B-Naive_B_cells|blood / Manually curated celltypes from each tissue

ARMC3 CARMIL1 SCN3A

4.89e-04172403f16f90d17feac1ee52fd513907b28456865fd31d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RASGEF1C PHACTR2 CARMIL1

4.97e-041734032e35bf2b5534a289d93a09faae660f665c131062
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 ARMC3 SCN3A

4.97e-041734030b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 ARMC3 SCN3A

4.97e-04173403a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 ARMC3 SCN3A

4.97e-041734034830136f1f1976e00ac9af9062a531ac42533041
ToppCellfacs-SCAT-Fat-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RACGAP1 GIMAP4 GIMAP8

5.06e-0417440387fa5deff5c1aabb342d674f05ad17c4c0e50d01
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 GIMAP8 MRPL22

5.06e-041744034a18b51501eaaeb7907e99316ba8ae15b2c7d529
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ODAD4 SPAG17 ARMC3

5.06e-04174403f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GIMAP4 GIMAP8 PLPPR4

5.06e-0417440318ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

ODAD4 SPAG17 ARMC3

5.14e-04175403c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 GIMAP8 RGS13

5.14e-04175403c1e082538f31b5c98ac63f71dcca4a1211a14708
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 GIMAP8 RGS13

5.14e-04175403c36b4526970db9ccfbe2c70b00961fab9f13b133
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 GIMAP8 RGS13

5.14e-041754032f9b5bdf8a62e8e99d1c4f677a8e5525bfd3b4ce
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TIAM1 PCNX4 CARMIL1

5.23e-041764036c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCellCiliated_cells-A-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

ODAD4 SPAG17 ARMC3

5.23e-041764031c364155f46b9a7c995bdc2cc2333c437cd90f5b
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ODAD4 SPAG17 PLPPR4

5.23e-04176403d6d7e4e937d49a5c0d16322c8dd3bf9e97eb8732
ToppCellPND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ODAD4 SPAG17 PLPPR4

5.23e-04176403c03d80df2550c0d2b0452326480d6bf21d20fdd2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RACGAP1 GIMAP4 GIMAP8

5.23e-0417640327c5ddd67de52101360ef7de8fcfa041066d97db
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RACGAP1 GIMAP4 GIMAP8

5.31e-04177403ffc4c675b25ffe8bd3441ce26dd0984fef4b3b88
DrugChloroprene

GIMAP4 CASP8AP2 ODAD4 AKAP9 PHF20L1 ARMC3 TIAM1 TRIO CARMIL1 SPTBN1 SCN3A

1.41e-0513484011ctd:D002737
DrugAndrosterone [53-41-8]; Down 200; 13.8uM; MCF7; HT_HG-U133A

KATNIP HERC6 PHF20L1 TMEM19 CARMIL1

2.20e-051944055696_DN
DrugSpironolactone [52-01-7]; Up 200; 9.6uM; PC3; HT_HG-U133A

KATNIP DSC3 TIAM1 GPATCH2L CEP290

2.26e-051954052064_UP
DrugSulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A

AKAP9 DSC3 TIAM1 TRIO CEP290

2.43e-051984057366_DN
DrugTriamcinolone [124-94-7]; Down 200; 10.2uM; PC3; HT_HG-U133A

EVPL TIAM1 TRIO RNF19A SPTBN1

2.43e-051984055835_DN
DrugAztreonam [78110-38-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

AKAP9 HERC6 TRIO RNF19A ZNF335

2.49e-051994055535_DN
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

SET TRIO

2.29e-0417392DOID:0060307 (is_implicated_in)
Diseaseblood barium measurement

TIAM1 GPATCH2L

9.30e-0434392EFO_0021528
Diseasebone quantitative ultrasound measurement

GIMAP8 SPTBN1

1.22e-0339392EFO_0004514

Protein segments in the cluster

PeptideGeneStartEntry
LDSIKSKSKDSVWEK

AKAP9

806

Q99996
SSGRRKAKKKWRKDS

EHMT2

336

Q96KQ7
LSKSATKEKGWRKSK

ARMC3

671

Q5W041
KWNKRPDKSSRSSKT

CASP8AP2

996

Q9UKL3
KWRSAKEFESRIVKS

MKRN4P

351

Q13434
VKRWVRSDSTKSKNK

GDF2

211

Q9UK05
LRKAERSWSCSREKK

KATNIP

6

O60303
SWTEKKQRRKTTATL

PCNX4

551

Q63HM2
WRRERAKVETKTVSK

EVPL

1301

Q92817
RDTFKKLTKKEWISS

HERC6

441

Q8IVU3
WRKKKTSDKFRETSA

PHACTR2

46

O75167
RHSKDKKKTRARKWG

ADAMTS9

231

Q9P2N4
KRSFTIWLSDKRKQT

DSC3

91

Q14574
ETWKTESKTIKEEKR

CEP290

831

O15078
LREDLKRKETKWSST

CENPJ

1006

Q9HC77
KRKETKWSSTHSRLR

CENPJ

1011

Q9HC77
FLSESRSWRKKKVSI

GIMAP8

286

Q8ND71
KSAKKQRLSRWKENT

GPATCH2L

161

Q9NWQ4
TKKVTKMDSKKWSTR

CARMIL1

1031

Q5VZK9
KKIASRWSRISRAKK

RGS13

71

O14921
RKWFKVPSKKEETST

PHF20L1

206

A8MW92
SASLDISRKWEKKNK

MRPL22

36

Q9NWU5
ARWEAASKETIKKTT

PRKN

401

O60260
TKKCEKRSSSWKETE

GIMAP4

66

Q9NUV9
KWKASLKSEKTVRQL

ODAD4

176

Q96NG3
SKSTKIKWKSGKDVT

SETSIP

176

P0DME0
IKWKSGKDVTKRSSQ

SETSIP

181

P0DME0
IKWKSGKDLTKRSSQ

SET

171

Q01105
SEASKLSSKSAKEWR

SCN3A

486

Q9NY46
LSSKSAKEWRNRRKK

SCN3A

491

Q9NY46
DWDSSLVKTFKLKKR

RACGAP1

166

Q9H0H5
KTWRHTASSKRWKEK

SPAG17

1871

Q6Q759
TASSKRWKEKIDKTR

SPAG17

1876

Q6Q759
ETKSWIREKTKVIES

SPTBN1

966

Q01082
KWFREIVKSKSESET

ADGRE3

611

Q9BY15
SSARAKWLKAAEKTV

PLPPR4

551

Q7Z2D5
SSDVVWETKPKKKAR

VPS13A

2551

Q96RL7
KKKRSKSADIWREDS

TIAM1

166

Q13009
TKWSKEATAGKKSKS

RNF19A

661

Q9NV58
KDWKGSKDVLRKASS

SH3PXD2B

486

A1X283
SRLKKTWAKVRTAKF

RASGEF1C

311

Q8N431
VITVSSRKSRWAKLK

VN1R4

106

Q7Z5H5
SSSKLTKWKGEVKKR

TMEM19

106

Q96HH6
KKGRLRKWSTSTKSQ

ZNF335

281

Q9H4Z2
SWHTALRLRKKSEKK

TRIO

2631

O75962