Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.12e-06	114	40	5	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.71e-06	124	40	5	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	7.66e-06	137	40	5	GO:0019783
GeneOntologyMolecularFunction	telomerase RNA binding	DHX36 TENT4B HNRNPC	1.66e-05	25	40	3	GO:0070034
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.91e-05	192	40	5	GO:0008234
GeneOntologyMolecularFunction	chromatin binding	NCOR1 TSPYL5 NCOR2 FMR1 TFAP2A TFAP2B RBL2 HNRNPC	9.11e-05	739	40	8	GO:0003682
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	DHX36 DCLRE1A TENT4B TOP1MT FEN1	1.69e-04	262	40	5	GO:0140097
GeneOntologyMolecularFunction	G-quadruplex RNA binding	DHX36 FMR1	1.74e-04	10	40	2	GO:0002151
GeneOntologyMolecularFunction	N6-methyladenosine-containing RNA reader activity	FMR1 HNRNPC	4.04e-04	15	40	2	GO:1990247
GeneOntologyMolecularFunction	nuclear receptor binding	NCOR1 NCOR2 TRIP12 DDX54	5.23e-04	187	40	4	GO:0016922
GeneOntologyMolecularFunction	5'-3' exonuclease activity	DCLRE1A FEN1	5.87e-04	18	40	2	GO:0008409
GeneOntologyMolecularFunction	nuclear retinoid X receptor binding	NCOR1 NCOR2	9.64e-04	23	40	2	GO:0046965
GeneOntologyMolecularFunction	protein-RNA adaptor activity	FMR1 HNRNPC	1.05e-03	24	40	2	GO:0140517
GeneOntologyMolecularFunction	transcription corepressor activity	NCOR1 NCOR2 TFAP2A DDX54	1.11e-03	229	40	4	GO:0003714
GeneOntologyMolecularFunction	DNA exonuclease activity, producing 5'-phosphomonoesters	DCLRE1A FEN1	1.14e-03	25	40	2	GO:0016895
GeneOntologyMolecularFunction	mRNA 5'-UTR binding	DHX36 FMR1	1.14e-03	25	40	2	GO:0048027
GeneOntologyMolecularFunction	DNA exonuclease activity	DCLRE1A FEN1	1.23e-03	26	40	2	GO:0004529
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DHX36 DCLRE1A TENT4B TOP1MT FEN1 DDX54	1.67e-03	645	40	6	GO:0140640
GeneOntologyMolecularFunction	poly(U) RNA binding	FMR1 HNRNPC	2.11e-03	34	40	2	GO:0008266
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	NCOR1 TRIP12	2.11e-03	34	40	2	GO:0046966
GeneOntologyMolecularFunction	poly-pyrimidine tract binding	FMR1 HNRNPC	2.77e-03	39	40	2	GO:0008187
GeneOntologyMolecularFunction	histone deacetylase binding	DHX36 NCOR1 NCOR2	3.16e-03	147	40	3	GO:0042826
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	NCOR1 DDX54	5.05e-03	53	40	2	GO:0030331
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	NCOR1 NCOR2	5.43e-03	55	40	2	GO:0042974
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.23e-06	125	38	5	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	6.45e-06	144	38	5	GO:0070646
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG NCOR1 NCOR2	5.86e-05	41	38	3	GO:0061436
GeneOntologyBiologicalProcess	negative regulation of catabolic process	DHX36 FMN2 ERFE NCOR1 TENT4B HNRNPC	1.07e-04	418	38	6	GO:0009895
GeneOntologyBiologicalProcess	DNA metabolic process	DHX36 FMN2 DCLRE1A TENT4B FMR1 TOP1MT TRIP12 HNRNPC FEN1	1.19e-04	1081	38	9	GO:0006259
GeneOntologyBiologicalProcess	nucleobase-containing compound catabolic process	DHX36 NCOR1 TENT4B FMR1 PRKAG2 HNRNPC FEN1	2.45e-04	696	38	7	GO:0034655
GeneOntologyBiologicalProcess	telomere maintenance	DHX36 TENT4B HNRNPC FEN1	2.53e-04	168	38	4	GO:0000723
GeneOntologyBiologicalProcess	regulation of telomere maintenance via telomere lengthening	DHX36 TENT4B HNRNPC	2.78e-04	69	38	3	GO:1904356
GeneOntologyBiologicalProcess	regulation of catabolic process	DHX36 FMN2 UBR3 ERFE NCOR1 TENT4B FMR1 PRKAG2 HNRNPC	3.57e-04	1252	38	9	GO:0009894
GeneOntologyBiologicalProcess	regulation of ketone metabolic process	ERFE NCOR1 NCOR2 PRKAG2	3.95e-04	189	38	4	GO:0010565
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L3 UBR3 TSPYL5 USP17L4 USP17L2 USP17L1 TRIP12 USP17L8	4.20e-04	1009	38	8	GO:0070647
GeneOntologyBiologicalProcess	negative regulation of androgen receptor signaling pathway	NCOR1 NCOR2	4.42e-04	17	38	2	GO:0060766
GeneOntologyBiologicalProcess	telomere organization	DHX36 TENT4B HNRNPC FEN1	4.80e-04	199	38	4	GO:0032200
GeneOntologyBiologicalProcess	RNA stabilization	DHX36 TENT4B HNRNPC	5.68e-04	88	38	3	GO:0043489
GeneOntologyBiologicalProcess	skin development	FLG NCOR1 NCOR2 TFAP2A TFAP2B	5.79e-04	373	38	5	GO:0043588
GeneOntologyBiologicalProcess	telomere maintenance via telomere lengthening	DHX36 TENT4B HNRNPC	6.07e-04	90	38	3	GO:0010833
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L3 UBR3 TSPYL5 USP17L4 USP17L2 USP17L1 TRIP12 USP17L8	6.37e-04	1074	38	8	GO:0043687
Domain	UCH	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.08e-07	71	40	5	PF00443
Domain	USP_2	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.08e-07	71	40	5	PS00973
Domain	USP_3	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.38e-07	72	40	5	PS50235
Domain	USP_dom	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.38e-07	72	40	5	IPR028889
Domain	Peptidase_C19_UCH	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.38e-07	72	40	5	IPR001394
Domain	GPS2_interact	NCOR1 NCOR2	4.47e-06	2	40	2	PF15784
Domain	N-CoR_GPS2_interact	NCOR1 NCOR2	4.47e-06	2	40	2	IPR031557
Domain	USP_CS	USP17L3 USP17L2 USP17L1 USP17L8	1.18e-05	66	40	4	IPR018200
Domain	USP_1	USP17L3 USP17L4 USP17L2 USP17L8	1.49e-05	70	40	4	PS00972
Domain	TF_AP2	TFAP2A TFAP2B	4.45e-05	5	40	2	IPR004979
Domain	TF_AP2_C	TFAP2A TFAP2B	4.45e-05	5	40	2	IPR013854
Domain	TF_AP-2	TFAP2A TFAP2B	4.45e-05	5	40	2	PF03299
Domain	HABP4_PAI-RBP1	USP17L3 USP17L2	5.27e-04	16	40	2	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L3 USP17L2	5.27e-04	16	40	2	IPR006861
Domain	SANT_dom	NCOR1 NCOR2	1.41e-03	26	40	2	IPR017884
Domain	SANT	NCOR1 NCOR2	1.63e-03	28	40	2	PS51293
Domain	Myb_DNA-binding	NCOR1 NCOR2	2.54e-03	35	40	2	PF00249
Domain	KH_1	PNO1 FMR1	2.99e-03	38	40	2	PF00013
Domain	MYB_LIKE	NCOR1 NCOR2	2.99e-03	38	40	2	PS50090
Domain	-	PNO1 FMR1	3.15e-03	39	40	2	3.30.1370.10
Domain	KH	PNO1 FMR1	3.31e-03	40	40	2	SM00322
Domain	KH_dom	PNO1 FMR1	3.31e-03	40	40	2	IPR004087
Domain	KH_TYPE_1	PNO1 FMR1	3.65e-03	42	40	2	PS50084
Domain	KH_dom_type_1	PNO1 FMR1	4.00e-03	44	40	2	IPR004088
Domain	SANT	NCOR1 NCOR2	5.13e-03	50	40	2	SM00717
Domain	SANT/Myb	NCOR1 NCOR2	5.54e-03	52	40	2	IPR001005
Pathway	REACTOME_RAS_PROCESSING	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.54e-08	45	30	5	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.69e-05	191	30	5	MM15289
Pathway	REACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX	NCOR1 NCOR2	9.13e-05	7	30	2	M27899
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	9.37e-05	221	30	5	M27578
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	NCOR1 NCOR2	1.56e-04	9	30	2	M29809
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	1.56e-04	9	30	2	MM15509
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	1.95e-04	10	30	2	M27764
Pathway	REACTOME_DEUBIQUITINATION	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	2.08e-04	262	30	5	MM15286
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	2.38e-04	11	30	2	MM15510
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	2.85e-04	12	30	2	M27765
Pathway	PID_ERA_GENOMIC_PATHWAY	NCOR1 NCOR2 DDX54	3.32e-04	64	30	3	M200
Pathway	REACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME	NCOR1 NCOR2	3.37e-04	13	30	2	M29766
Pathway	REACTOME_DEUBIQUITINATION	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.83e-04	299	30	5	M27574
Pathway	REACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_GROWTH_FACTORS_AND_THEIR_RECEPTORS	TFAP2A TFAP2B	4.52e-04	15	30	2	M27766
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	5.07e-04	318	30	5	MM15278
Pathway	REACTOME_SPECIFICATION_OF_THE_NEURAL_PLATE_BORDER	TFAP2A TFAP2B	5.84e-04	17	30	2	M48248
Pathway	REACTOME_SUMOYLATION	NCOR2 TFAP2A TFAP2B HNRNPC	6.53e-04	189	30	4	M27214
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	8.12e-04	20	30	2	M27237
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	1.38e-03	26	30	2	MM15502
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	NCOR1 NCOR2	1.60e-03	28	30	2	M6177
Pathway	REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY	NCOR1 NCOR2	1.96e-03	31	30	2	M669
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	NCOR1 NCOR2	2.09e-03	32	30	2	M27900
Pathway	WP_ADIPOGENESIS	NCOR1 NCOR2 RBL2	2.65e-03	131	30	3	M39505
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L3 NCOR2 USP17L4 USP17L2 USP17L1 TFAP2A TFAP2B HNRNPC USP17L8	2.73e-03	1475	30	9	M19806
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	NCOR1 NCOR2	2.78e-03	37	30	2	M29790
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2A TFAP2B	2.93e-03	38	30	2	M27757
Pathway	WP_ADIPOGENESIS_GENES	NCOR1 NCOR2 RBL2	3.01e-03	137	30	3	MM15970
Pathway	WP_OVARIAN_INFERTILITY	NCOR1 FMR1	3.09e-03	39	30	2	M39458
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.44e-13	10	41	5	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	1.39e-12	12	41	5	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.51e-12	14	41	5	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	2.03e-11	19	41	5	28067227
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.55e-11	21	41	5	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.55e-11	21	41	5	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.55e-11	21	41	5	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.55e-11	21	41	5	14583620
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.55e-11	21	41	5	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.55e-11	21	41	5	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.59e-11	22	41	5	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	7.39e-11	24	41	5	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	9.23e-11	25	41	5	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	1.14e-10	26	41	5	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	2.06e-10	29	41	5	32527007
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.10e-10	33	41	5	20228807
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	15780755
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	20403174
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	19188362
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	11941478
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	14699124
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.80e-10	34	41	5	21448158
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	5.59e-10	35	41	5	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	5.59e-10	35	41	5	16611142
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	6.49e-10	36	41	5	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	7.50e-10	37	41	5	20228808
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.60e-09	50	41	5	31806660
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.24e-08	81	41	5	12838346
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L3 USP17L4 USP17L1 USP17L8	3.11e-07	48	41	4	16421571
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DHX36 NCOR1 TENT4B FMR1 TRIP12 TFAP2A HNRNPC FEN1 DDX54	5.03e-07	847	41	9	35850772
Pubmed	Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.	NCOR1 NCOR2	1.36e-06	2	41	2	21131350
Pubmed	Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface.	TFAP2A TFAP2B	1.36e-06	2	41	2	12694203
Pubmed	Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.	NCOR1 NCOR2	1.36e-06	2	41	2	26166430
Pubmed	Conditional Deletion of AP-2α and AP-2β in the Developing Murine Retina Leads to Altered Amacrine Cell Mosaics and Disrupted Visual Function.	TFAP2A TFAP2B	1.36e-06	2	41	2	29715367
Pubmed	AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development.	FMR1 TFAP2A	1.36e-06	2	41	2	15930016
Pubmed	Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.	NCOR1 NCOR2	1.36e-06	2	41	2	19299558
Pubmed	Unique forms of human and mouse nuclear receptor corepressor SMRT.	NCOR1 NCOR2	1.36e-06	2	41	2	10077563
Pubmed	NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.	NCOR1 NCOR2	1.36e-06	2	41	2	29531310
Pubmed	Cloning and characterization of a second AP-2 transcription factor: AP-2 beta.	TFAP2A TFAP2B	1.36e-06	2	41	2	7555706
Pubmed	CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.	NCOR1 NCOR2	1.36e-06	2	41	2	27733359
Pubmed	AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis.	TFAP2A TFAP2B	1.36e-06	2	41	2	38237728
Pubmed	Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.	NCOR1 NCOR2	1.36e-06	2	41	2	39106294
Pubmed	Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.	TFAP2A TFAP2B	1.36e-06	2	41	2	32769099
Pubmed	Comparative analysis of AP-2 alpha and AP-2 beta gene expression during murine embryogenesis.	TFAP2A TFAP2B	1.36e-06	2	41	2	8989526
Pubmed	Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.	NCOR1 NCOR2	1.36e-06	2	41	2	22944139
Pubmed	AP2 transcription factor induces apoptosis in retinoblastoma cells.	TFAP2A TFAP2B	1.36e-06	2	41	2	20607706
Pubmed	Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.	NCOR1 NCOR2	1.36e-06	2	41	2	31208445
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	PNO1 TENT4B TRIP12 TFAP2A FEN1 DDX54	3.27e-06	349	41	6	25665578
Pubmed	Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.	NCOR1 NCOR2	4.06e-06	3	41	2	16030140
Pubmed	Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.	NCOR1 NCOR2	4.06e-06	3	41	2	34390859
Pubmed	Oligomerization of ETO is obligatory for corepressor interaction.	NCOR1 NCOR2	4.06e-06	3	41	2	11113190
Pubmed	A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens.	TFAP2A TFAP2B	4.06e-06	3	41	2	9758708
Pubmed	Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation.	TFAP2A TFAP2B	4.06e-06	3	41	2	11553286
Pubmed	Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.	NCOR1 NCOR2	4.06e-06	3	41	2	19098224
Pubmed	The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.	NCOR1 NCOR2	4.06e-06	3	41	2	16373395
Pubmed	Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.	TFAP2A TFAP2B	4.06e-06	3	41	2	32462520
Pubmed	Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.	NCOR1 NCOR2	4.06e-06	3	41	2	31404087
Pubmed	RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.	NCOR1 NCOR2	4.06e-06	3	41	2	12011091
Pubmed	EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.	NCOR1 NCOR2	4.06e-06	3	41	2	21518914
Pubmed	Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.	NCOR1 NCOR2	4.06e-06	3	41	2	22337871
Pubmed	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	NCOR1 NCOR2	4.06e-06	3	41	2	15802375
Pubmed	SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.	NCOR1 NCOR2	4.06e-06	3	41	2	36238311
Pubmed	The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.	NCOR1 NCOR2	4.06e-06	3	41	2	10406466
Pubmed	Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.	NCOR1 NCOR2	4.06e-06	3	41	2	36316474
Pubmed	Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.	NCOR1 NCOR2	4.06e-06	3	41	2	23292142
Pubmed	The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.	NCOR1 NCOR2	4.06e-06	3	41	2	18052923
Pubmed	Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.	NCOR1 NCOR2	4.06e-06	3	41	2	15016838
Pubmed	The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.	NCOR1 NCOR2	4.06e-06	3	41	2	11997503
Pubmed	Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.	NCOR1 NCOR2	4.06e-06	3	41	2	24268577
Pubmed	Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.	TFAP2A TFAP2B	4.06e-06	3	41	2	8661133
Pubmed	Transcriptional activation by Myc is under negative control by the transcription factor AP-2.	TFAP2A TFAP2B	4.06e-06	3	41	2	7729426
Pubmed	hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.	FMR1 HNRNPC	4.06e-06	3	41	2	20473314
Pubmed	Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression.	TFAP2A TFAP2B	4.06e-06	3	41	2	7559606
Pubmed	Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.	NCOR1 NCOR2	4.06e-06	3	41	2	18852122
Pubmed	MicroRNAs are mediators of androgen action in prostate and muscle.	NCOR1 NCOR2	8.12e-06	4	41	2	21048966
Pubmed	Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.	NCOR1 NCOR2	8.12e-06	4	41	2	19595715
Pubmed	Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.	NCOR1 NCOR2	8.12e-06	4	41	2	9819405
Pubmed	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	NCOR1 NCOR2	8.12e-06	4	41	2	18362166
Pubmed	Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.	NCOR1 NCOR2	8.12e-06	4	41	2	18632669
Pubmed	Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.	NCOR1 NCOR2	8.12e-06	4	41	2	16121196
Pubmed	The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.	TFAP2A TFAP2B	8.12e-06	4	41	2	18843039
Pubmed	Dichotomous engagement of HDAC3 activity governs inflammatory responses.	NCOR1 NCOR2	8.12e-06	4	41	2	32760002
Pubmed	A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.	NCOR1 NCOR2	8.12e-06	4	41	2	19147680
Pubmed	A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.	NCOR1 NCOR2	8.12e-06	4	41	2	12840002
Pubmed	A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning.	TFAP2A TFAP2B	8.12e-06	4	41	2	21829553
Pubmed	The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.	TFAP2A TFAP2B	8.12e-06	4	41	2	19115315
Pubmed	Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.	TFAP2A TFAP2B	8.12e-06	4	41	2	9765260
Pubmed	A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.	NCOR1 NCOR2	8.12e-06	4	41	2	32072640
Pubmed	NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.	NCOR1 NCOR2	8.12e-06	4	41	2	25421714
Pubmed	Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.	NCOR1 NCOR2	8.12e-06	4	41	2	15878880
Pubmed	FBI-1 functions as a novel AR co-repressor in prostate cancer cells.	NCOR1 NCOR2	8.12e-06	4	41	2	20812024
Pubmed	Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).	NCOR1 NCOR2	8.12e-06	4	41	2	17073437
Pubmed	The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.	NCOR1 NCOR2	8.12e-06	4	41	2	16024608
Pubmed	Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.	TFAP2A TFAP2B	8.12e-06	4	41	2	12749383
Cytoband	8p23.1	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	2.70e-07	154	41	5	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	2.13e-06	234	41	5	chr8p23
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 NCOR2	1.71e-03	53	21	2	532
GeneFamily	G protein-coupled receptors, Class A orphans	GPR22 GPR34	3.66e-03	78	21	2	262
Coexpression	MADAN_DPPA4_TARGETS	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	2.31e-07	86	41	5	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	8.63e-07	112	41	5	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	5.00e-06	160	41	5	MM1155
Coexpression	GSE17721_LPS_VS_CPG_0.5H_BMDC_UP	PNO1 NCOR1 TOP1MT DNAJC14 HNRNPC	1.41e-05	198	41	5	M3982
Drug	NSC 308880	TFAP2A TFAP2B RBL2	2.87e-06	17	38	3	CID000073599
Drug	panaxadiol	TFAP2A TFAP2B RBL2	3.44e-06	18	38	3	CID000073498
Drug	ginsenoside Rb2	TFAP2A TFAP2B RBL2	7.42e-06	23	38	3	CID000073598
Drug	halofenate	NCOR1 NCOR2	1.62e-05	4	38	2	CID000033584
Drug	nitrogen half-mustard	DCLRE1A FEN1	5.67e-05	7	38	2	CID000007901
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	4.07e-09	46	39	5	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L3 USP17L4 USP17L2 USP17L1 USP17L8	3.27e-08	69	39	5	DOID:1682 (implicated_via_orthology)
Disease	Clinodactyly	TFAP2A TFAP2B	1.02e-05	4	39	2	C4551485
Disease	Clinodactyly of fingers	TFAP2A TFAP2B	1.02e-05	4	39	2	C0265610
Disease	sleep disorder (implicated_via_orthology)	TFAP2A TFAP2B	9.29e-05	11	39	2	DOID:535 (implicated_via_orthology)
Disease	neutrophil collagenase measurement	ABCA13 HNRNPC	2.02e-04	16	39	2	EFO_0008248
Disease	cancer (implicated_via_orthology)	TOP1MT TRIP12 RBL2 FEN1	4.26e-04	268	39	4	DOID:162 (implicated_via_orthology)
Disease	obese body mass index status	TFAP2B HNRNPC	8.76e-04	33	39	2	EFO_0007041
Disease	Malignant neoplasm of liver	PRICKLE2 NCOR1 DDX54	8.78e-04	142	39	3	C0345904
Disease	Liver neoplasms	PRICKLE2 NCOR1 DDX54	8.78e-04	142	39	3	C0023903
Disease	Craniofacial Abnormalities	FMR1 TFAP2A TFAP2B	1.15e-03	156	39	3	C0376634
Disease	Cleft upper lip	TFAP2A TFAP2B	1.22e-03	39	39	2	C0008924
Disease	developmental disorder of mental health (implicated_via_orthology)	NCOR1 NCOR2	1.92e-03	49	39	2	DOID:0060037 (implicated_via_orthology)
Disease	factor VII activating protease measurement	TSPYL5 DCLRE1A	2.42e-03	55	39	2	EFO_0009368

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGKKNASQKRRSLRV	PRKAG2	21	Q9UGJ0
LRISKRRSKFPNSGK	GPR34	246	Q9UPC5
GVLRRAKSKNGGRSL	TFAP2A	251	P05549
KQTRALSGGLKRKLS	ABCA13	3971	Q86UQ4
RNNRKGNKGRSKSPR	FLG	131	P20930
KSKNGGRSLRERLEK	TFAP2B	276	Q92481
TKAQKQKRRGCRGSR	H2BW2	31	P0C1H6
LIKGKRKRRNSGSSD	RBL2	931	Q08999
SNKRKRDNKASGGRA	TENT4B	76	Q8NDF8
SKGRKTANSQGRRKG	NCOR2	566	Q9Y618
HRLGRKRSQADKRKG	DNAJC14	221	Q6Y2X3
SKRQRVSGNTSRRGK	HNRNPC	156	P07910
DTAKERKGKRARRQG	KIAA1109	2486	Q2LD37
RKKKGLRKRRGAASQ	DDX54	21	Q8TDD1
VRQSDKGVNGKKRSR	ERFE	86	Q4G0M1
FTQVTRKGGRRAKKR	PNO1	16	Q9NRX1
KKRKQQRTGKGNRRG	HEMGN	61	Q9BXL5
GRGQLHSRKRQKSKN	PRICKLE2	826	Q7Z3G6
NIDGKRSGKQKRTDR	DIRAS1	176	O95057
KRLSKSRQGSTQGRL	FEN1	326	P39748
EGSRLRTGKDRNQKK	FMR1	601	Q06787
QGKGRSRRSRNKQEK	FAM193B	826	Q96PV7
VSKANAKQRKGRAGR	DHX36	591	Q9H2U1
GSPSLRRKGNRKRNS	CMYA5	141	Q8N3K9
GKYQSKRSRNRKRAA	DCLRE1A	41	Q6PJP8
RIGTRFSTGQKKKAR	GPR22	241	Q99680
SNLRIRKNLSKGKGA	FMN2	76	Q9NZ56
NRLTQKGKKRSRGGR	PNMA8B	171	Q9ULN7
GRKTANSQGRRKGRI	NCOR1	571	O75376
RASTGKSRKEKGSNR	SAMD14	201	Q8IZD0
KGNVTRRRKKTHLGN	CLLU1-AS1	76	Q5K130
ASLQGRTRRAKGKNK	USP17L3	506	A6NCW0
ASLQGRTRRSKGKNK	USP17L4	506	A6NCW7
FKKRRTENGKSRNLR	WBP4	356	O75554
QGDGKSRSVLEKKRR	TOP1MT	511	Q969P6
ASLQGRTRRAKGKNK	USP17L1	506	Q7RTZ2
NKVKTRKSKRRSGEG	SNHG28	211	P0DPA3
GSQGLGKRKRVKLSS	UBR3	351	Q6ZT12
ASLQGRTRRSKGKNK	USP17L8	506	P0C7I0
RKSGATGGSRSQKRK	TRIP12	136	Q14669
ASLQGRTRRSKGKNK	USP17L2	506	Q6R6M4
SRAKNRGKGRAKARV	TSPYL5	11	Q86VY4