Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX10 SOX12 ETS1 GCM1 CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 GLI1 NR5A2 SMAD2 SMAD3 FOXJ1	4.38e-07	560	110	15	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX10 SOX12 ETS1 GCM1 CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 GLI1 NR5A2 SMAD2 SMAD3 FOXJ1	5.01e-07	566	110	15	GO:0001216
GeneOntologyMolecularFunction	co-SMAD binding	USP9Y SMAD2 SMAD3	3.45e-05	12	110	3	GO:0070410
GeneOntologyMolecularFunction	chromatin binding	SOX10 POLR2B ADNP STAT3 NEUROD1 SF3B1 EGR1 GLI1 NR5A2 AUTS2 MBD5 SMAD2 SMAD3 DNMT3A	5.49e-05	739	110	14	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX10 SOX12 ETS1 GCM1 CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 NFATC4 GLI1 NR5A2 HSFX1 SMAD2 SMAD3 DNMT3A FOXJ1	1.48e-04	1244	110	18	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX10 SOX12 ETS1 GCM1 CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 NFATC4 GLI1 NR5A2 HSFX1 SMAD2 SMAD3 DNMT3A FOXJ1	1.94e-04	1271	110	18	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX10 SOX12 ETS1 GCM1 ADNP CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 NFATC4 GLI1 ZBTB21 NR5A2 HSFX1 SMAD2 SMAD3 FOXJ1	2.43e-04	1412	110	19	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX10 SOX12 ETS1 GCM1 ADNP CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 NFATC4 GLI1 NR5A2 HSFX1 SMAD2 SMAD3 DNMT3A FOXJ1	3.67e-04	1459	110	19	GO:0000977
GeneOntologyMolecularFunction	tumor necrosis factor binding	A2M TNFRSF1B	6.20e-04	7	110	2	GO:0043120
GeneOntologyBiologicalProcess	embryo development	CDK20 A2M SOX10 CELF4 DSC3 TRIOBP GCM1 RICTOR ZP3 TFAP2C HOXB1 NEUROD1 SF3B1 RTL1 GLI1 NR5A2 DCHS1 NOCT ENDOG NODAL BAG6 SMAD2 SMAD3	2.32e-06	1437	112	23	GO:0009790
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	CDK20 SOX10 CELF4 DSC3 GCM1 RICTOR ZP3 TFAP2C HOXB1 SF3B1 RTL1 NR5A2 DCHS1 ENDOG NODAL SMAD2 SMAD3	1.07e-05	929	112	17	GO:0009792
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SOX10 SOX12 GPBP1 ETS1 GCM1 CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 SF3B1 EGR1 NFATC4 GLI1 NR5A2 AUTS2 NODAL NOS1 SMAD2 SMAD3 FOXJ1	1.66e-05	1390	112	21	GO:0045944
GeneOntologyBiologicalProcess	digestive tract morphogenesis	SOX10 GLI1 NODAL SMAD2 SMAD3	1.71e-05	59	112	5	GO:0048546
GeneOntologyBiologicalProcess	regulation of miRNA metabolic process	ZSWIM8 ETS1 STAT3 EGR1 NFATC4 SMAD3	2.09e-05	103	112	6	GO:2000628
GeneOntologyBiologicalProcess	developmental growth	SOX10 DDR1 SPART PTEN ADNP ZP3 TFAP2C STAT3 CDKL5 ALMS1 GLI1 ARID5B AUTS2 MBD5 SMAD2 SMAD3	3.28e-05	911	112	16	GO:0048589
GeneOntologyBiologicalProcess	miRNA metabolic process	ZSWIM8 ETS1 STAT3 EGR1 NFATC4 SMAD3	4.72e-05	119	112	6	GO:0010586
GeneOntologyBiologicalProcess	positive regulation of miRNA metabolic process	ZSWIM8 ETS1 STAT3 EGR1 SMAD3	4.83e-05	73	112	5	GO:2000630
GeneOntologyBiologicalProcess	central nervous system development	CDK20 PCSK1 SOX10 SOX12 ZDHHC16 GCM1 PTEN TFAP2C STAT3 HOXB1 NEUROD1 GLI1 TNFRSF1B MDGA1 NODAL PCDH9 BAG6 FOXJ1	7.71e-05	1197	112	18	GO:0007417
GeneOntologyBiologicalProcess	regulation of miRNA transcription	ETS1 STAT3 EGR1 NFATC4 SMAD3	8.94e-05	83	112	5	GO:1902893
GeneOntologyBiologicalProcess	miRNA transcription	ETS1 STAT3 EGR1 NFATC4 SMAD3	9.47e-05	84	112	5	GO:0061614
GeneOntologyBiologicalProcess	in utero embryonic development	SOX10 CELF4 DSC3 GCM1 ZP3 TFAP2C SF3B1 RTL1 ENDOG NODAL SMAD2 SMAD3	9.66e-05	596	112	12	GO:0001701
GeneOntologyBiologicalProcess	chordate embryonic development	CDK20 SOX10 CELF4 DSC3 GCM1 ZP3 TFAP2C HOXB1 SF3B1 RTL1 DCHS1 ENDOG NODAL SMAD2 SMAD3	1.14e-04	906	112	15	GO:0043009
GeneOntologyBiologicalProcess	rhythmic process	A2M PTEN ADNP ZP3 EGR1 PHLPP1 PRKCG NOCT RPE65	1.54e-04	360	112	9	GO:0048511
GeneOntologyBiologicalProcess	primary miRNA processing	STAT3 SMAD2 SMAD3	1.66e-04	20	112	3	GO:0031053
GeneOntologyBiologicalProcess	sensory organ development	CDK20 DDR1 CELF4 ZDHHC16 TRIOBP STAT3 DZANK1 NEUROD1 ALMS1 DCHS1 ROM1 RPE65 SMAD3	1.66e-04	730	112	13	GO:0007423
GeneOntologyBiologicalProcess	floor plate morphogenesis	CDK20 NODAL	1.74e-04	4	112	2	GO:0033505
GeneOntologyBiologicalProcess	digestive tract development	SOX10 GLI1 DCHS1 NODAL SMAD2 SMAD3	1.83e-04	152	112	6	GO:0048565
GeneOntologyBiologicalProcess	neural retina development	STAT3 NEUROD1 ALMS1 ROM1 RPE65	2.36e-04	102	112	5	GO:0003407
GeneOntologyBiologicalProcess	embryonic organ development	CDK20 A2M TRIOBP GCM1 HOXB1 NEUROD1 RTL1 GLI1 NODAL SMAD2 SMAD3	2.40e-04	561	112	11	GO:0048568
GeneOntologyBiologicalProcess	endocrine system development	PCSK1 NEUROD1 GLI1 ARID5B SMAD2 SMAD3	2.49e-04	161	112	6	GO:0035270
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	DLGAP2 CELF4 DLGAP4 PTEN ADNP STAT3 CDKL5 EGR1 NFATC4 SORCS3 PRKCG NOS1	2.59e-04	663	112	12	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	DLGAP2 CELF4 DLGAP4 PTEN ADNP STAT3 CDKL5 EGR1 NFATC4 SORCS3 PRKCG NOS1	2.63e-04	664	112	12	GO:0099177
GeneOntologyBiologicalProcess	eye development	CDK20 CELF4 ZDHHC16 STAT3 DZANK1 NEUROD1 ALMS1 ROM1 RPE65 SMAD3	2.89e-04	480	112	10	GO:0001654
GeneOntologyBiologicalProcess	visual system development	CDK20 CELF4 ZDHHC16 STAT3 DZANK1 NEUROD1 ALMS1 ROM1 RPE65 SMAD3	3.03e-04	483	112	10	GO:0150063
GeneOntologyBiologicalProcess	digestive system development	SOX10 GLI1 DCHS1 NODAL SMAD2 SMAD3	3.03e-04	167	112	6	GO:0055123
GeneOntologyBiologicalProcess	positive regulation of miRNA transcription	ETS1 STAT3 EGR1 SMAD3	3.39e-04	61	112	4	GO:1902895
GeneOntologyBiologicalProcess	sensory system development	CDK20 CELF4 ZDHHC16 STAT3 DZANK1 NEUROD1 ALMS1 ROM1 RPE65 SMAD3	3.45e-04	491	112	10	GO:0048880
GeneOntologyBiologicalProcess	developmental process involved in reproduction	A2M CELF4 GCM1 CNTLN NCOA4 USP9Y PTEN CREB3L4 ZP3 DDIAS ALMS1 GLI1 ARID5B NODAL BAG6 DNMT3A FOXJ1	3.54e-04	1235	112	17	GO:0003006
GeneOntologyBiologicalProcess	growth	SOX10 DDR1 SPART RICTOR PTEN ADNP ZP3 TFAP2C STAT3 CDKL5 ALMS1 GLI1 ARID5B AUTS2 MBD5 SMAD2 SMAD3	3.54e-04	1235	112	17	GO:0040007
GeneOntologyBiologicalProcess	nodal signaling pathway	NODAL SMAD2 SMAD3	3.70e-04	26	112	3	GO:0038092
GeneOntologyBiologicalProcess	regulation of nervous system process	SOX10 DLGAP2 CELF4 DLGAP4 PTEN TNFRSF1B	3.90e-04	175	112	6	GO:0031644
GeneOntologyBiologicalProcess	ventral midline development	CDK20 GLI1	4.32e-04	6	112	2	GO:0007418
GeneOntologyBiologicalProcess	head development	PCSK1 SOX12 ZDHHC16 PTEN TFAP2C HOXB1 NEUROD1 GLI1 ARID5B MDGA1 NODAL PCDH9 BAG6 FOXJ1	4.56e-04	919	112	14	GO:0060322
GeneOntologyBiologicalProcess	signal transduction involved in regulation of gene expression	NEUROD1 SMAD2 SMAD3	4.62e-04	28	112	3	GO:0023019
GeneOntologyBiologicalProcess	animal organ morphogenesis	DDR1 TRIOBP PTEN TFAP2C STAT3 HOXB1 DZANK1 NEUROD1 ALMS1 GLI1 ARID5B NR5A2 DCHS1 ROM1 NODAL SMAD2 SMAD3	4.83e-04	1269	112	17	GO:0009887
GeneOntologyBiologicalProcess	regulation of developmental growth	SPART PTEN ADNP ZP3 STAT3 CDKL5 ALMS1 GLI1 MBD5	4.86e-04	421	112	9	GO:0048638
GeneOntologyBiologicalProcess	adrenal gland development	ARID5B SMAD2 SMAD3	5.14e-04	29	112	3	GO:0030325
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	CDK20 SOX10 DDR1 GCM1 PTEN TFAP2C ALMS1 NFATC4 DCHS1 NODAL SMAD3	5.51e-04	619	112	11	GO:0002009
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	5.54e-04	187	112	6	GO:0007156
GeneOntologyBiologicalProcess	eye photoreceptor cell differentiation	STAT3 DZANK1 ALMS1 ROM1	6.38e-04	72	112	4	GO:0001754
Domain	Cadherin_CS	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	4.74e-05	109	111	6	IPR020894
Domain	CADHERIN_1	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	5.80e-05	113	111	6	PS00232
Domain	Cadherin	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	5.80e-05	113	111	6	PF00028
Domain	CADHERIN_2	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	6.09e-05	114	111	6	PS50268
Domain	-	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	6.09e-05	114	111	6	2.60.40.60
Domain	CA	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	6.40e-05	115	111	6	SM00112
Domain	Cadherin-like	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	6.71e-05	116	111	6	IPR015919
Domain	Cadherin	DSC3 PCDHGA11 PCDHGA4 CDH24 DCHS1 PCDH9	7.39e-05	118	111	6	IPR002126
Domain	ALMS_motif	ALMS1 CEP295	1.05e-04	3	111	2	IPR029299
Domain	ALMS_motif	ALMS1 CEP295	1.05e-04	3	111	2	PF15309
Domain	SAPAP	DLGAP2 DLGAP4	3.46e-04	5	111	2	IPR005026
Domain	GKAP	DLGAP2 DLGAP4	3.46e-04	5	111	2	PF03359
Domain	DWB	SMAD2 SMAD3	9.57e-04	8	111	2	SM00524
Domain	MH2	SMAD2 SMAD3	9.57e-04	8	111	2	PS51076
Domain	MH1	SMAD2 SMAD3	9.57e-04	8	111	2	PS51075
Domain	-	SMAD2 SMAD3	9.57e-04	8	111	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD2 SMAD3	9.57e-04	8	111	2	IPR013019
Domain	Dwarfin	SMAD2 SMAD3	9.57e-04	8	111	2	IPR013790
Domain	MH2	SMAD2 SMAD3	9.57e-04	8	111	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD2 SMAD3	9.57e-04	8	111	2	IPR001132
Domain	MAD_homology1_Dwarfin-type	SMAD2 SMAD3	2.22e-03	12	111	2	IPR003619
Domain	DWA	SMAD2 SMAD3	2.22e-03	12	111	2	SM00523
Domain	MH1	SMAD2 SMAD3	2.22e-03	12	111	2	PF03165
Domain	SMAD_dom-like	SMAD2 SMAD3	3.98e-03	16	111	2	IPR017855
Domain	-	SMAD2 SMAD3	3.98e-03	16	111	2	2.60.200.10
Pathway	KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY	NODAL SMAD2 SMAD3	9.66e-06	8	80	3	M47849
Pathway	WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER	BARD1 RICTOR PTEN STAT3 SMAD2 SMAD3	3.70e-05	110	80	6	M48043
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	RICTOR PTEN SMAD2 SMAD3	4.93e-05	36	80	4	M39569
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	PTEN TFAP2C STAT3 NR5A2 PRKCG NODAL SMAD2 SMAD3 DNMT3A	5.03e-05	301	80	9	MM15983
Pathway	KEGG_PATHWAYS_IN_CANCER	LAMB4 ETS1 NCOA4 PTEN STAT3 GLI1 PRKCG SMAD2 SMAD3	9.07e-05	325	80	9	M12868
Pathway	WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING	STAT3 PRKCG TNFRSF1B NOS1 SMAD2 SMAD3	1.42e-04	140	80	6	M42572
Pathway	WP_INTEGRATED_CANCER_PATHWAY	BARD1 PTEN SMAD2 SMAD3	1.55e-04	48	80	4	M39628
Pathway	WP_HEPATITIS_B_INFECTION	CREB3L4 STAT3 NFATC4 PRKCG SMAD2 SMAD3	2.14e-04	151	80	6	M39801
Pathway	REACTOME_SIGNALING_BY_NODAL	NODAL SMAD2 SMAD3	2.87e-04	23	80	3	M511
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX10 SOX12 ETS1 GCM1 ADNP CREB3L4 TFAP2C STAT3 HOXB1 NEUROD1 EGR1 NFATC4 GLI1 NR5A2 SMAD2 SMAD3 FOXJ1	6.36e-09	908	113	17	19274049
Pubmed	Lefty inhibits glioma growth by suppressing Nodal-activated Smad and ERK1/2 pathways.	NODAL SMAD2 SMAD3	3.34e-08	3	113	3	25304053
Pubmed	Nodal promotes the self-renewal of human colon cancer stem cells via an autocrine manner through Smad2/3 signaling pathway.	NODAL SMAD2 SMAD3	3.34e-08	3	113	3	24696849
Pubmed	Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation.	PTEN SMAD2 SMAD3	3.34e-08	3	113	3	34638474
Pubmed	Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway.	NODAL SMAD2 SMAD3	3.34e-08	3	113	3	25557170
Pubmed	Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway.	NODAL SMAD2 SMAD3	3.34e-08	3	113	3	27659524
Pubmed	Perilipin 5 Ameliorates Hepatic Stellate Cell Activation via SMAD2/3 and SNAIL Signaling Pathways and Suppresses STAT3 Activation.	STAT3 SMAD2 SMAD3	1.33e-07	4	113	3	34571833
Pubmed	Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.	STAT3 SMAD2 SMAD3	1.33e-07	4	113	3	26194464
Pubmed	A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium.	PTEN SMAD2 SMAD3	1.33e-07	4	113	3	28524854
Pubmed	Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.	PTEN SMAD2 SMAD3	1.33e-07	4	113	3	18482992
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	POLR2B ZDHHC16 ETS1 BARD1 STAT3 HOXB1 NEUROD1 EGR1 NFATC4 GLI1 NR5A2 SMAD2 SMAD3 DNMT3A FOXJ1	1.72e-07	877	113	15	20211142
Pubmed	Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.	ETS1 SMAD2 SMAD3	3.32e-07	5	113	3	18955504
Pubmed	Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.	NODAL SMAD2 SMAD3	3.32e-07	5	113	3	15308665
Pubmed	Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.	NODAL SMAD2 SMAD3	3.32e-07	5	113	3	15150278
Pubmed	TGF-β promotes glioma cell growth via activating Nodal expression through Smad and ERK1/2 pathways.	NODAL SMAD2 SMAD3	3.32e-07	5	113	3	24370825
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	A2M ETS1 RICTOR PTEN CREB3L4 STAT3 NFATC4 GLI1 SMAD2 SMAD3	3.96e-07	371	113	10	25241761
Pubmed	Signaling via Alk5 controls the ontogeny of lung Clara cells.	CYP2F1 PTEN SMAD3 FOXJ1	6.06e-07	21	113	4	20147383
Pubmed	Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes.	NODAL SMAD2 SMAD3	6.63e-07	6	113	3	20571128
Pubmed	Leptin augments myofibroblastic conversion and fibrogenic activity of human peritoneal mesothelial cells: a functional implication for peritoneal fibrosis.	STAT3 SMAD2 SMAD3	6.63e-07	6	113	3	17142261
Pubmed	Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells.	NODAL SMAD2 SMAD3	6.63e-07	6	113	3	21532621
Pubmed	An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome.	GLI1 BAG6 SMAD2 SMAD3	7.39e-07	22	113	4	28380258
Pubmed	Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.	ME2 SMAD2 SMAD3	1.16e-06	7	113	3	19066393
Pubmed	Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.	NODAL SMAD2 SMAD3	1.16e-06	7	113	3	27466203
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	PTEN STAT3 HOXB1 NEUROD1 GLI1 ARID5B NR5A2 NOCT NODAL DNMT3A	1.33e-06	424	113	10	21731673
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	POLR2B ETS1 RICTOR NCOA4 ANKHD1 ME2 DNTTIP2 NEUROD1 GLI1 KCNJ3 ARID5B CEP295 MTO1 SMAD2 BRWD1	2.42e-06	1084	113	15	11544199
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CDK20 ETS1 ANKHD1 ADNP STAT3 NDUFV2 SF3B1 NFATC4 GLI1 ZBTB21 SMAD2 SMAD3 FOXJ1	4.49e-06	857	113	13	25609649
Pubmed	Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo.	NODAL SMAD2 SMAD3	5.41e-06	11	113	3	23742838
Pubmed	Endoglin is required for myogenic differentiation potential of neural crest stem cells.	SOX10 SMAD2 SMAD3	9.33e-06	13	113	3	17628518
Pubmed	Smad signaling pathways regulate pancreatic endocrine development.	NEUROD1 SMAD2 SMAD3	9.33e-06	13	113	3	23603491
Pubmed	Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development.	SOX10 PTEN NEUROD1	9.33e-06	13	113	3	23393595
Pubmed	Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.	NODAL SMAD2 SMAD3	9.33e-06	13	113	3	17341133
Pubmed	Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop.	HOXB1 NODAL SMAD2	9.33e-06	13	113	3	33171097
Pubmed	PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure.	PTEN GLI1	1.05e-05	2	113	2	25600212
Pubmed	Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.	SMAD2 SMAD3	1.05e-05	2	113	2	18210139
Pubmed	Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis.	SMAD2 SMAD3	1.05e-05	2	113	2	20010874
Pubmed	Identification of GLI1 and KIAA0825 Variants in Two Families with Postaxial Polydactyly.	KIAA0825 GLI1	1.05e-05	2	113	2	37107627
Pubmed	Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R.	SMAD2 SMAD3	1.05e-05	2	113	2	12700238
Pubmed	Asthma-derived fibroblast to myofibroblast transition is enhanced in comparison to fibroblasts derived from non-asthmatic patients in 3D in vitro culture due to Smad2/3 signalling.	SMAD2 SMAD3	1.05e-05	2	113	2	33245228
Pubmed	GLI1 activates pro-fibrotic pathways in myelofibrosis fibrocytes.	STAT3 GLI1	1.05e-05	2	113	2	35595725
Pubmed	Negative impact on clinical outcome of the mutational co-occurrence of SF3B1 and DNMT3A in refractory anemia with ring sideroblasts (RARS).	SF3B1 DNMT3A	1.05e-05	2	113	2	27771989
Pubmed	Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.	STAT3 TNFRSF1B	1.05e-05	2	113	2	21994466
Pubmed	Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development.	SMAD2 SMAD3	1.05e-05	2	113	2	32705438
Pubmed	PTEN expression elicited by EGR-1 transcription factor in calyculin A-induced apoptotic cells.	PTEN EGR1	1.05e-05	2	113	2	15517593
Pubmed	Smad2/3 Linker Phosphorylation Is a Possible Marker of Pancreatic Stem/Progenitor Cells in the Regenerative Phase of Acute Pancreatitis.	SMAD2 SMAD3	1.05e-05	2	113	2	28099259
Pubmed	Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.	PTEN DNMT3A	1.05e-05	2	113	2	20467490
Pubmed	Arsenite Disrupts Zinc-Dependent TGFβ2-SMAD Activity During Murine Cardiac Progenitor Cell Differentiation.	SMAD2 SMAD3	1.05e-05	2	113	2	26354774
Pubmed	Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.	STAT3 SMAD3	1.05e-05	2	113	2	36791253
Pubmed	Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle.	SMAD2 SMAD3	1.05e-05	2	113	2	25185661
Pubmed	Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.	SMAD2 SMAD3	1.05e-05	2	113	2	17192514
Pubmed	Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy.	PTEN GLI1	1.05e-05	2	113	2	22998871
Pubmed	TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.	SMAD2 SMAD3	1.05e-05	2	113	2	28557134
Pubmed	Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.	SMAD2 SMAD3	1.05e-05	2	113	2	21732483
Pubmed	Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.	PTEN PHLPP1	1.05e-05	2	113	2	21840483
Pubmed	Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification.	SMAD2 SMAD3	1.05e-05	2	113	2	26905010
Pubmed	Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells.	SMAD2 SMAD3	1.05e-05	2	113	2	21496353
Pubmed	Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis.	SMAD2 SMAD3	1.05e-05	2	113	2	33769459
Pubmed	Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.	SMAD2 SMAD3	1.05e-05	2	113	2	15665291
Pubmed	Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?	PTEN GLI1	1.05e-05	2	113	2	31377403
Pubmed	Disrupted hippocampal network physiology following PTEN deletion from newborn dentate granule cells.	PTEN GLI1	1.05e-05	2	113	2	27597527
Pubmed	Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-β1-induced Smad and p38/ERK signaling.	SMAD2 SMAD3	1.05e-05	2	113	2	26919280
Pubmed	Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice.	SMAD2 SMAD3	1.05e-05	2	113	2	34710825
Pubmed	The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.	SMAD2 SMAD3	1.05e-05	2	113	2	21229365
Pubmed	CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.	CBLL1 PTEN	1.05e-05	2	113	2	39012313
Pubmed	Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.	SMAD2 SMAD3	1.05e-05	2	113	2	22385658
Pubmed	Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma.	EGR1 SMAD3	1.05e-05	2	113	2	18772333
Pubmed	EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer.	PTEN EGR1	1.05e-05	2	113	2	24704156
Pubmed	Dose-dependent Nodal/Smad signals pattern the early mouse embryo.	NODAL SMAD2	1.05e-05	2	113	2	24704361
Pubmed	[Expression and significance of Smad2/3 and HPV16 E7 in cervical intraepithelial neoplasia and cervical carcinoma].	SMAD2 SMAD3	1.05e-05	2	113	2	17927854
Pubmed	Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors.	SMAD2 SMAD3	1.05e-05	2	113	2	29588413
Pubmed	Neovibsanin B increases extracellular matrix proteins in optic nerve head cells via activation of Smad signalling pathway.	SMAD2 SMAD3	1.05e-05	2	113	2	26045877
Pubmed	Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis.	SMAD2 SMAD3	1.05e-05	2	113	2	34445177
Pubmed	Essential role of Smad3 in angiotensin II-induced vascular fibrosis.	SMAD2 SMAD3	1.05e-05	2	113	2	16556868
Pubmed	Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle.	SMAD2 SMAD3	1.05e-05	2	113	2	21883378
Pubmed	A proteomics analysis reveals that A2M might be regulated by STAT3 in persistent allergic rhinitis.	A2M STAT3	1.05e-05	2	113	2	27228572
Pubmed	Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.	SMAD2 SMAD3	1.05e-05	2	113	2	25908723
Pubmed	ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits.	ALMS1 CEP295	1.05e-05	2	113	2	30421101
Pubmed	Expression pattern and phosphorylation status of Smad2/3 in different subtypes of human first trimester trophoblast.	SMAD2 SMAD3	1.05e-05	2	113	2	28864007
Pubmed	From PTEN loss of expression to RICTOR role in smooth muscle differentiation: complex involvement of the mTOR pathway in leiomyosarcomas and pleomorphic sarcomas.	RICTOR PTEN	1.05e-05	2	113	2	22080063
Pubmed	Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition.	SMAD2 SMAD3	1.05e-05	2	113	2	36050359
Pubmed	Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development.	SMAD2 SMAD3	1.05e-05	2	113	2	11984875
Pubmed	Polycomb determines responses to smad2/3 signaling in embryonic stem cell differentiation and in reprogramming.	SMAD2 SMAD3	1.05e-05	2	113	2	23666711
Pubmed	Smad3-STAT3 crosstalk in pathophysiological contexts.	STAT3 SMAD3	1.05e-05	2	113	2	29140406
Pubmed	Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.	SMAD2 SMAD3	1.05e-05	2	113	2	16382155
Pubmed	Formation of the definitive endoderm in mouse is a Smad2-dependent process.	SMAD2 SMAD3	1.05e-05	2	113	2	10862745
Pubmed	Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes.	SMAD2 SMAD3	1.05e-05	2	113	2	24086574
Pubmed	Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance.	SF3B1 DNMT3A	1.05e-05	2	113	2	32112088
Pubmed	SF3B1 mutations in patients with myelodysplastic syndromes: the mutation is stable during disease evolution.	SF3B1 DNMT3A	1.05e-05	2	113	2	24723457
Pubmed	Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium.	SMAD2 SMAD3	1.05e-05	2	113	2	35780861
Pubmed	Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.	SMAD2 SMAD3	1.05e-05	2	113	2	29174331
Pubmed	SMAD2/3 Phosphorylation Is Downregulated in T Cells in HIV-Infected Patients.	SMAD2 SMAD3	1.05e-05	2	113	2	36226468
Pubmed	Increased TGF-β1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling.	SMAD2 SMAD3	1.05e-05	2	113	2	22228025
Pubmed	Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells.	SMAD2 SMAD3	1.05e-05	2	113	2	26992562
Pubmed	Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.	SMAD2 SMAD3	1.05e-05	2	113	2	15972691
Pubmed	Smad2 and 3 transcription factors control muscle mass in adulthood.	SMAD2 SMAD3	1.05e-05	2	113	2	19357234
Pubmed	PTEN deletion increases hippocampal granule cell excitability in male and female mice.	PTEN GLI1	1.05e-05	2	113	2	28855130
Pubmed	Inhibiting Smad2/3 signaling in pluripotent mouse embryonic stem cells enhances endoderm formation by increasing transcriptional priming of lineage-specifying target genes.	SMAD2 SMAD3	1.05e-05	2	113	2	27012147
Pubmed	Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro.	SMAD2 SMAD3	1.05e-05	2	113	2	24925688
Pubmed	Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo.	SMAD2 SMAD3	1.05e-05	2	113	2	15520018
Pubmed	Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary.	SMAD2 SMAD3	1.05e-05	2	113	2	30111581
Pubmed	The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.	SMAD2 SMAD3	1.05e-05	2	113	2	17074756
Cytoband	19q13.4	LILRB3 PRKCG KIR2DL1 KIR2DS3	4.53e-05	79	113	4	19q13.4
GeneFamily	SMAD family	SMAD2 SMAD3	5.19e-04	8	79	2	750
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 DLGAP2 POLR2B ABRAXAS2 ALMS1 RTL1 MTO1	1.35e-07	155	112	7	441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 DDR1 NCOA4 LARS2 PIGT SLC12A9 PCDH9	7.54e-07	200	112	7	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M LILRB3 ETS1 NCOA4 EGR1 GLI1	4.89e-06	172	112	6	d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell	Thalamus-Macroglia\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX10 DDR1 SPART PPP1R13B PHLPP1 TEX52	6.56e-06	181	112	6	4f62b63854a4e9fea6e839f0340e78392c66fb0e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LMTK3 AK3 KCNJ3 RBFOX1 PCDH9 DNMT3A	6.77e-06	182	112	6	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CELF4 LARS2 NEUROD1 KCNJ3 MDGA1	7.43e-06	185	112	6	cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 PPP1R13B NCOA4 ADNP LARS2 DNMT3A	7.43e-06	185	112	6	a2cae8c657e4f4d121476798e424876f7e247973
ToppCell	18-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	PCSK1 SOX10 DLGAP2 CELF4 NEUROD1 RBFOX1	7.43e-06	185	112	6	f8fc7b12b4e18d23d84e95488be93c4352d325f3
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 PPP1R13B NCOA4 ADNP LARS2 DNMT3A	7.43e-06	185	112	6	d50406a9a5b8d75110ba5985741aa2293950c543
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M CELF4 ADNP NEUROD1 KCNJ3 PCDH9	7.90e-06	187	112	6	b426a67b5669019115b58295ce7d304beeb75825
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 AK3 RBFOX1 SORCS3 NOS1 PCDH9	8.14e-06	188	112	6	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CDK20 CNTLN ALMS1 ZBTB21 CEP295 FOXJ1	8.65e-06	190	112	6	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M ADNP NEUROD1 KCNJ3 PCDH9 DNMT3A	9.18e-06	192	112	6	3b0a52e4e77ae4539a034dcb419773b8e2aa5d51
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPBP1 ETS1 LARS2 STAT3 SF3B1 NOCT	1.03e-05	196	112	6	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 DDR1 NCOA4 LARS2 PIGT PCDH9	1.16e-05	200	112	6	f0c338877e39226a90c4effe12f6501d33542a73
ToppCell	ASK452-Epithelial-Secretory\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	CYP2F1 BARD1 DNTTIP2 NOCT TMC5	2.10e-05	132	112	5	49ba24e24b3127b5257a88a0ee0246c9843c580a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M GCM1 NR5A2 NOCT TNFRSF1B	4.40e-05	154	112	5	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-Treg\|ICU-NoSEP / Disease, Lineage and Cell Type	CDK20 ETS1 USP9Y DZANK1 ARID5B	5.12e-05	159	112	5	d065ec02a4f3672ba53d4fea66029f1ce68f367f
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Thalamus / BrainAtlas - Mouse McCarroll V32	PCSK1 TYRP1 NEUROD1 MDGA1 NOS1	5.43e-05	161	112	5	0605134a342d74ae81f33700d6ddfcd6e03aeb7b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 RBFOX1 SORCS3 NOS1 PCDH9	5.59e-05	162	112	5	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 CELF4 NEUROD1 KCNJ3 MDGA1	6.28e-05	166	112	5	ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCell	Club_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	CYP2F1 LMTK3 RBFOX1 TMC5 SMAD3	6.83e-05	169	112	5	03b303af8a26c6ff196507fe24f5bd3d75d7b1af
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	ETS1 ANKHD1 ZP3 KIAA0825 ARID5B	7.63e-05	173	112	5	e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK1 DSC3 NEUROD1 CSN1S1 TMC5	8.50e-05	177	112	5	a25ca82c4bda033ee113f8ecb4a541b22e7a29ca
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK1 DSC3 NEUROD1 CSN1S1 TMC5	8.50e-05	177	112	5	fbead6e56271b1f1d447f89857de444ebe7157b0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_MORN2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PCSK1 DSC3 NEUROD1 CSN1S1 TMC5	8.73e-05	178	112	5	b0fc56f583cb3f2977fe2306994c0d478c9a6b1b
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP39 DZANK1 LIAT1 TMC5 FOXJ1	8.73e-05	178	112	5	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SOX10 COL26A1 EFS ARHGAP39 ME2	9.20e-05	180	112	5	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 RBFOX1 SORCS3 NOS1 PCDH9	9.69e-05	182	112	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 RBFOX1 SORCS3 NOS1 PCDH9	1.02e-04	184	112	5	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELF4 DZANK1 NEUROD1 KCNJ3 MDGA1	1.05e-04	185	112	5	70de48988c1f8e0809afc8092b663aa439d8e528
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M ADNP NEUROD1 KCNJ3 PCDH9	1.05e-04	185	112	5	0382bfbc96c23403b18fe439d8070ea9a7d29fd2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M CELF4 NEUROD1 KCNJ3 MDGA1	1.05e-04	185	112	5	c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AK3 RBFOX1 SORCS3 NOS1 PCDH9	1.10e-04	187	112	5	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M ADNP NEUROD1 KCNJ3 PCDH9	1.10e-04	187	112	5	cfdc1585c80d2bb475d9145395fb50a88c53f838
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELF4 LMTK3 NEUROD1 PRKCG MDGA1	1.13e-04	188	112	5	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AK3 RBFOX1 SORCS3 NOS1 PCDH9	1.13e-04	188	112	5	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	ETS1 EGR1 AUTS2 TMC5 SMAD3	1.13e-04	188	112	5	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 AK3 RBFOX1 NOS1 PCDH9	1.16e-04	189	112	5	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP2F1 LARS2 LIAT1 TMC5 FOXJ1	1.19e-04	190	112	5	576c45a30a4808b47433bc6c2c41396135556c40
ToppCell	tumor_Lung-T/NK_cells-Exhausted_Tfh\|tumor_Lung / Location, Cell class and cell subclass	ETS1 STAT3 NDUFV2 ARID5B TNFRSF1B	1.22e-04	191	112	5	3e259eba83f8159d1a1a96b98d0e867fe547c5e7
ToppCell	15-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	PCSK1 NEUROD1 KCNJ3 RBFOX1 KCNH5	1.22e-04	191	112	5	76311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 PTEN LARS2 PRKCG BRWD1	1.25e-04	192	112	5	2de242d81dc085ae734eb7d1f091af9a542e0866
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 PTEN LARS2 PRKCG BRWD1	1.25e-04	192	112	5	ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M ADNP NEUROD1 KCNJ3 PCDH9	1.25e-04	192	112	5	97c312c82ec025c13052f8d424b11c0034c8ea54
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 DLGAP2 RTL1 KCNJ3 KCNH5	1.28e-04	193	112	5	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 DLGAP2 RTL1 KCNJ3 KCNH5	1.28e-04	193	112	5	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M PCDHGA11 GCM1 USP9Y BRWD1	1.28e-04	193	112	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ALMS1 LIAT1 ZBTB21 CEP295 FOXJ1	1.31e-04	194	112	5	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ETS1 PTEN CDKL5 NFATC4 NODAL	1.31e-04	194	112	5	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 DSC3 KCNJ3 RBFOX1 KCNH5	1.34e-04	195	112	5	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	DDR1 CYP2F1 TFAP2C EGR1 TMC5	1.34e-04	195	112	5	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	Endothelial\|World / shred by cell class for bronchial biopsy	A2M ETS1 NR5A2 DCHS1 TNFRSF1B	1.34e-04	195	112	5	f0e46e859f7a9bdead3203889f7e20fa21f76ff0
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 DSC3 KCNJ3 RBFOX1 KCNH5	1.34e-04	195	112	5	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	AK3 RBFOX1 SORCS3 NOS1 PCDH9	1.37e-04	196	112	5	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	Tracheal-10x5prime-Stromal-Schwann\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SOX10 ARHGAP39 KCNJ3 SORCS3 PCDH9	1.37e-04	196	112	5	b6226163d9fc93ecfff2115bb74408303a000490
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	BARD1 TFAP2C EGR1 NFATC4 FOXJ1	1.40e-04	197	112	5	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	BARD1 TFAP2C EGR1 NFATC4 FOXJ1	1.40e-04	197	112	5	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-Treg\|ICU-NoSEP / Disease, condition lineage and cell class	CDK20 ETS1 USP9Y DZANK1 ARID5B	1.44e-04	198	112	5	1ed4dfe5565328cb0f7ef31e6b2f67dfbdf3e2ac
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ADNP NEUROD1 RBFOX1 AUTS2 MDGA1	1.51e-04	200	112	5	7bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 DDR1 LARS2 PHLPP1 PCDH9	1.51e-04	200	112	5	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 CREB3L4 DZANK1 RNF123 TMC5	1.51e-04	200	112	5	68b0f987c4fb8078675475f4f1e71302f832ef69
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DDR1 CREB3L4 DZANK1 RNF123 TMC5	1.51e-04	200	112	5	1b527bebbca1ef8c52449e40beb9358e37494e04
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	ETS1 DNTTIP2 STAT3 SF3B1 ARID5B	1.51e-04	200	112	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
Disease	Schizophrenia	SOX10 DLGAP2 DDR1 VRK2 ADNP LARS2 ME2 NDUFV2 KCNJ3 AUTS2 MAGEC1 TNFRSF1B MDGA1 NOS1	3.85e-06	883	107	14	C0036341
Disease	feeling miserable measurement	DLGAP2 VRK2 CELF4 SORCS3 CLUH	1.04e-05	79	107	5	EFO_0009598
Disease	autosomal dominant intellectual developmental disorder (implicated_via_orthology)	AUTS2 MBD5	3.90e-05	3	107	2	DOID:0060307 (implicated_via_orthology)
Disease	ovarian cancer (is_implicated_in)	BARD1 PTEN STAT3 SMAD2	5.19e-05	56	107	4	DOID:2394 (is_implicated_in)
Disease	Lung Neoplasms	A2M DDR1 RICTOR PTEN TYRP1 EGR1 DNMT3A	5.29e-05	265	107	7	C0024121
Disease	Malignant neoplasm of lung	A2M DDR1 RICTOR PTEN TYRP1 EGR1 DNMT3A	5.41e-05	266	107	7	C0242379
Disease	Left Ventricle Remodeling	NOS1 SMAD2 SMAD3	5.88e-05	21	107	3	C0600520
Disease	Ventricular Remodeling	NOS1 SMAD2 SMAD3	5.88e-05	21	107	3	C0600519
Disease	colon cancer (is_marker_for)	RICTOR PTEN STAT3 NR5A2	6.38e-05	59	107	4	DOID:219 (is_marker_for)
Disease	idiopathic pulmonary fibrosis (is_marker_for)	DDR1 STAT3 SMAD2	7.79e-05	23	107	3	DOID:0050156 (is_marker_for)
Disease	smoking status measurement	VRK2 CELF4 ALMS1 KCNJ3 RBFOX1 ARID5B AUTS2 SORCS3 CEP295 NOCT MDGA1 PCDH9 SMAD3 BRWD1	7.85e-05	1160	107	14	EFO_0006527
Disease	renal cell carcinoma (is_marker_for)	PTEN STAT3 PLD2 TNFRSF1B SMAD2	1.06e-04	128	107	5	DOID:4450 (is_marker_for)
Disease	Sezary Syndrome	PTEN TNFRSF1B DNMT3A	1.27e-04	27	107	3	C0036920
Disease	angiomyolipoma (is_marker_for)	PTEN STAT3	1.29e-04	5	107	2	DOID:3314 (is_marker_for)
Disease	unipolar depression, mood disorder	VRK2 CELF4 RBFOX1 SORCS3 CLUH	1.31e-04	134	107	5	EFO_0003761, EFO_0004247
Disease	serum metabolite measurement	LAMB4 COL26A1 PKD1L2 ZP3 STAT3 ALMS1 RBFOX1 ARID5B SORCS3 NOCT MDGA1 ENDOG	1.65e-04	945	107	12	EFO_0005653
Disease	Craniofacial Abnormalities	PTEN HOXB1 SMAD2 SMAD3 DNMT3A	2.67e-04	156	107	5	C0376634
Disease	Loeys-Dietz Syndrome	SMAD2 SMAD3	2.70e-04	7	107	2	C2697932
Disease	endometrial cancer (is_marker_for)	TNFRSF1B SMAD2 SMAD3	2.79e-04	35	107	3	DOID:1380 (is_marker_for)
Disease	Reperfusion Injury	ETS1 PTEN STAT3 EGR1	3.15e-04	89	107	4	C0035126
Disease	visual epilepsy (biomarker_via_orthology)	PCSK1 EGR1 PLD2 ENDOG	3.29e-04	90	107	4	DOID:11832 (biomarker_via_orthology)
Disease	chronic lymphocytic leukemia (is_marker_for)	STAT3 AK3	4.61e-04	9	107	2	DOID:1040 (is_marker_for)
Disease	Hepatocellular Adenoma	A2M PTEN	4.61e-04	9	107	2	C0206669
Disease	neuroticism measurement	DLGAP2 VRK2 CELF4 RBFOX1 SORCS3 NOCT MBD5 NOS1 CLUH PCDH9 BAG6	4.70e-04	909	107	11	EFO_0007660
Disease	Liver Cirrhosis	A2M PTEN TNFRSF1B SMAD3	5.48e-04	103	107	4	C0023890
Disease	Uterine Cancer	BARD1 SMAD3	5.75e-04	10	107	2	C0153567
Disease	Fibrosis, Liver	A2M PTEN TNFRSF1B SMAD3	5.90e-04	105	107	4	C0239946
Disease	Acute Promyelocytic Leukemia	STAT3 GLI1 DNMT3A	6.28e-04	46	107	3	C0023487
Disease	congestive heart failure (biomarker_via_orthology)	DDR1 PLD2 ENDOG NOS1	6.33e-04	107	107	4	DOID:6000 (biomarker_via_orthology)
Disease	cocaine use	TFAP2C DNMT3A	7.01e-04	11	107	2	C3496069
Disease	Copper-Overload Cirrhosis	STAT3 SMAD2	7.01e-04	11	107	2	C1876165
Disease	N-acetylhistidine measurement	COL26A1 ALMS1	7.01e-04	11	107	2	EFO_0800022
Disease	osteosarcoma (is_marker_for)	DDR1 EGR1	7.01e-04	11	107	2	DOID:3347 (is_marker_for)
Disease	peripheral arterial disease, traffic air pollution measurement	DLGAP2 KCNJ3 RBFOX1 MBD5 SMAD2	7.21e-04	194	107	5	EFO_0004265, EFO_0007908
Disease	Crohn Disease	STAT3 SMAD3 DNMT3A	8.03e-04	50	107	3	C0010346
Disease	hepatocellular carcinoma (is_marker_for)	DDR1 RICTOR PTEN AK3 SF3B1 DNMT3A	8.18e-04	301	107	6	DOID:684 (is_marker_for)
Disease	lymphangioleiomyomatosis (is_marker_for)	RICTOR STAT3	8.40e-04	12	107	2	DOID:3319 (is_marker_for)
Disease	Carcinoma, Granular Cell	DDR1 PTEN STAT3 TYRP1	8.57e-04	116	107	4	C0205644
Disease	Adenocarcinoma, Tubular	DDR1 PTEN STAT3 TYRP1	8.57e-04	116	107	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	DDR1 PTEN STAT3 TYRP1	8.57e-04	116	107	4	C0205642
Disease	Carcinoma, Cribriform	DDR1 PTEN STAT3 TYRP1	8.57e-04	116	107	4	C0205643
Disease	Adenocarcinoma, Basal Cell	DDR1 PTEN STAT3 TYRP1	8.57e-04	116	107	4	C0205641
Disease	Adenocarcinoma	DDR1 PTEN STAT3 TYRP1	8.57e-04	116	107	4	C0001418
Disease	depressive symptom measurement	DLGAP2 VRK2 CELF4 RBFOX1 SORCS3 NOS1 PCDH9	9.40e-04	426	107	7	EFO_0007006
Disease	wellbeing measurement	DLGAP2 VRK2 CELF4 RBFOX1 AUTS2 SORCS3 NOS1 PCDH9 SMAD3	9.48e-04	692	107	9	EFO_0007869
Disease	skin melanoma (is_marker_for)	DDR1 STAT3	9.90e-04	13	107	2	DOID:8923 (is_marker_for)
Disease	gallbladder cancer (is_implicated_in)	RICTOR GLI1	9.90e-04	13	107	2	DOID:3121 (is_implicated_in)
Disease	Disorder of eye	TYRP1 ALMS1 ROM1 SEMA4A RPE65	1.07e-03	212	107	5	C0015397
Disease	progesterone measurement	RBFOX1 SMAD2	1.15e-03	14	107	2	EFO_0007004
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BARD1 PTEN	1.15e-03	14	107	2	C0677776
Disease	age-related hearing impairment	TRIOBP NDUFV2 RBFOX1 ARID5B AUTS2 MDGA1	1.19e-03	324	107	6	EFO_0005782
Disease	bipolar disorder	DLGAP2 VRK2 PPP1R13B ANKHD1 PEBP4 SF3B1 SLC12A9 AUTS2	1.22e-03	577	107	8	MONDO_0004985
Disease	mood instability measurement	VRK2 CELF4 RBFOX1 SORCS3	1.23e-03	128	107	4	EFO_0008475
Disease	Tinnitus	RBFOX1 ARID5B SORCS3 KCNH5	1.31e-03	130	107	4	HP_0000360
Disease	myelodysplastic syndrome (implicated_via_orthology)	SF3B1 EGR1	1.33e-03	15	107	2	DOID:0050908 (implicated_via_orthology)
Disease	unipolar depression, autism spectrum disorder	RBFOX1 SORCS3	1.33e-03	15	107	2	EFO_0003756, EFO_0003761
Disease	Brain Ischemia	STAT3 EGR1 TNFRSF1B	1.37e-03	60	107	3	C0007786
Disease	Cerebral Ischemia	STAT3 EGR1 TNFRSF1B	1.37e-03	60	107	3	C0917798
Disease	unipolar depression	VRK2 CELF4 CNTLN SF3B1 RBFOX1 DCHS1 AUTS2 SORCS3 NOCT NOS1 PCDH9 KCNH5	1.43e-03	1206	107	12	EFO_0003761
Disease	age at menarche	PCSK1 DLGAP2 DZANK1 ALMS1 RTL1 RBFOX1 SMAD2 BRWD1	1.47e-03	594	107	8	EFO_0004703
Disease	diet measurement	DLGAP2 VRK2 CELF4 PTEN LARS2 RBFOX1 AUTS2 SORCS3 MBD5 MDGA1 DNMT3A	1.50e-03	1049	107	11	EFO_0008111
Disease	smoking behavior	KCNJ3 RBFOX1 ARID5B AUTS2 PCDH9 BRWD1	1.55e-03	341	107	6	EFO_0004318
Disease	pre-malignant neoplasm (biomarker_via_orthology)	STAT3 GLI1	1.71e-03	17	107	2	DOID:0060071 (biomarker_via_orthology)
Disease	Fetal Alcohol Syndrome	ADNP NOS1	1.71e-03	17	107	2	C0015923
Disease	cognitive function measurement, self reported educational attainment	TRIOBP ALMS1 KCNJ3 RBFOX1 AUTS2 SORCS3	1.90e-03	355	107	6	EFO_0004784, EFO_0008354
Disease	Takayasu arteritis	DLGAP2 DDR1 RBFOX1 BAG6	2.10e-03	148	107	4	EFO_1001857
Disease	Non-alcoholic Fatty Liver Disease	PTEN NR5A2 TNFRSF1B	2.13e-03	70	107	3	C0400966
Disease	Nonalcoholic Steatohepatitis	PTEN NR5A2 TNFRSF1B	2.13e-03	70	107	3	C3241937
Disease	portal hypertension (implicated_via_orthology)	PTEN NOS1	2.14e-03	19	107	2	DOID:10762 (implicated_via_orthology)
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	BARD1 SEMA4A	2.14e-03	19	107	2	C1333991
Disease	squamous cell carcinoma (is_marker_for)	EGR1 RPE65	2.14e-03	19	107	2	DOID:1749 (is_marker_for)
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	BARD1 SEMA4A	2.14e-03	19	107	2	C2936783
Disease	colorectal cancer, inflammatory bowel disease	DLGAP2 ALMS1	2.14e-03	19	107	2	EFO_0003767, MONDO_0005575
Disease	childhood trauma measurement, alcohol consumption measurement	DLGAP2 PCDHGA11 PCDHGA4	2.22e-03	71	107	3	EFO_0007878, EFO_0007979
Disease	neoplasm of mature B-cells	ETS1 PHLPP1	2.37e-03	20	107	2	EFO_0000096
Disease	Retinitis pigmentosa	ROM1 SEMA4A RPE65	2.49e-03	74	107	3	cv:C0035334
Disease	asthma, endometriosis	ETS1 PTEN SMAD3	2.49e-03	74	107	3	EFO_0001065, MONDO_0004979
Disease	prostate cancer (is_marker_for)	NCOA4 PTEN PHLPP1 SMAD3	2.54e-03	156	107	4	DOID:10283 (is_marker_for)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	VRK2 ALMS1 KCNJ3 RBFOX1 ARID5B AUTS2 SORCS3 NOCT BRWD1	2.57e-03	801	107	9	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	colorectal cancer (is_marker_for)	DDR1 RICTOR PTEN GLI1	2.60e-03	157	107	4	DOID:9256 (is_marker_for)
Disease	Autistic Disorder	DLGAP2 PTEN ADNP RBFOX1 TNFRSF1B	2.66e-03	261	107	5	C0004352
Disease	feeling "fed-up" measurement	CELF4 LARS2 RNF123	2.69e-03	76	107	3	EFO_0009588
Disease	Parkinson's disease (is_implicated_in)	A2M NDUFV2 NOS1	2.69e-03	76	107	3	DOID:14330 (is_implicated_in)
Disease	Hepatitis, Chronic	STAT3 SMAD2	2.87e-03	22	107	2	C0019189
Disease	Chronic active hepatitis	STAT3 SMAD2	2.87e-03	22	107	2	C0520463
Disease	Chronic Persistent Hepatitis	STAT3 SMAD2	2.87e-03	22	107	2	C0149519
Disease	Cryptogenic Chronic Hepatitis	STAT3 SMAD2	2.87e-03	22	107	2	C0524611
Disease	Carcinoma of lung	RICTOR PTEN	3.14e-03	23	107	2	C0684249
Disease	sphingomyelin 24:1 measurement	ME2 RBFOX1	3.14e-03	23	107	2	EFO_0010398
Disease	irritability measurement	VRK2 CELF4 AUTS2	3.34e-03	82	107	3	EFO_0009594
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	TRIOBP KCNJ3 RBFOX1 AUTS2 SORCS3 BRWD1	3.34e-03	398	107	6	EFO_0003756, EFO_0003888, EFO_0004337
Disease	lung non-small cell carcinoma (is_marker_for)	PTEN STAT3 EGR1 SMAD3	3.39e-03	169	107	4	DOID:3908 (is_marker_for)
Disease	childhood trauma measurement	SORCS3 PCDH9	3.41e-03	24	107	2	EFO_0007979
Disease	Lynch syndrome (is_implicated_in)	SMAD2 SMAD3	3.41e-03	24	107	2	DOID:3883 (is_implicated_in)
Disease	nephrotic syndrome (biomarker_via_orthology)	A2M NOS1	3.41e-03	24	107	2	DOID:1184 (biomarker_via_orthology)
Disease	cortical surface area measurement	VRK2 COL26A1 EFS ETS1 TRIOBP ARHGAP39 CNTLN ABRAXAS2 HOXB1 SF3B1 KIAA0825 AUTS2	3.51e-03	1345	107	12	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
AESVAYHAQNNPPVP	ADNP	576	Q9H2P0
QYFFTAPLPAHPSEL	CDK20	286	Q8IZL9
PPYSDFHPNNQESTL	ABRAXAS2	306	Q15018
EAYAAAINPLHQPAP	TFAP2C	81	Q92754
QQDSYEFVSPSPPAD	BARD1	176	Q99728
LPQESDPDYSAQVPH	CNTLN	436	Q9NXG0
NNHDQEFDPPKVYPP	DNMT3A	611	Q9Y6K1
NAPNHPSPAEYVEVL	BAG6	266	P46379
PPQNSVPHYAEADIV	DDR1	561	Q08345
PSPQHQDYVAPDLPS	ALMS1	2906	Q8TCU4
PVGHSLDPAANYNSP	DLGAP2	491	Q9P1A6
SEFPEHQPYPRSDVE	DLGAP2	721	Q9P1A6
YNSHFEVPEESPFPS	DLGAP4	76	Q9Y2H0
QATPPKNYQPAAHSA	PPP1R13B	586	Q96KQ4
APVGHFYEPQAPSAE	A2M	1191	P01023
NLASPEPYLHPSQSE	ARHGAP39	641	Q9C0H5
HYDPSQFLTPQEFNP	CYP2F1	396	P24903
DNDNPPVFPHSSYSA	PCDHGA11	446	Q9Y5H2
SPEFYFDTPNPTRSH	MDGA1	636	Q8NFP4
INDNPPTFPHASYSA	PCDHGA4	476	Q9Y5G9
LDANDHAPAFPVPAY	DCHS1	1846	Q96JQ0
HYFPQSPPQGEDSLS	MAGEC1	546	O60732
EDSLSPHYFPQSPPQ	MAGEC1	556	O60732
QSPPQGEDSLSPHYF	MAGEC1	566	O60732
GEDSLSPHYFPQSPQ	MAGEC1	571	O60732
SPHYFPQSPQGEDSL	MAGEC1	576	O60732
PQSPQGEDSLSPHYF	MAGEC1	581	O60732
SIEDQPSAFNPFHVY	KIAA0825	1181	Q8IV33
DFPSLNPEYEREPNH	GPBP1	136	Q86WP2
HIPDNPSIPFSFTNE	MTO1	256	Q9Y2Z2
QADAKHPFYPIPEQA	KCNH5	891	Q8NCM2
HPASGRVYNIEFNPP	AK3	131	Q9UIJ7
PHANPSNPFYEALST	LMTK3	506	Q96Q04
FPPFSDISNPTAHEN	CSN1S1	161	P47710
QDAPEPPAFTQAAYH	CDH24	366	Q86UP0
PPAFTQAAYHLTVPE	CDH24	371	Q86UP0
FNPQADTGEQPYEHL	EGR1	86	P18146
FDSEDYPAALPNHKP	ETS1	286	P14921
SHPLPLVQPQDEFYD	PCDH9	1081	Q9HC56
QELSAYQAPSPPAHS	PEBP4	131	Q96S96
GVSQPDVFNHYPFAE	DDIAS	841	Q8IXT1
NPAAHLEPFNRPSTF	AUTS2	736	Q8WXX7
HNYAAPFPPESCFQE	MYCLP1	206	P12525
HSPYQFSAPSDPLDI	KIR2DS3	106	Q14952
EDAPAQEPSYQSPKF	GLI1	916	P08151
QGFTYVNPDFVHPDA	PRKCG	671	P05129
QSPHDEDPQAVTYAP	LILRB3	531	O75022
DIPYFQTKNIPPHDD	RICTOR	1441	Q6R327
FDPYNPPSVSSNVTH	PKD1L2	296	Q7Z442
TPSFEYQPDPWNTHV	NOS1	706	P29475
PHHYNPNSLPQFTED	CBLL1	421	Q75N03
NSPLQEEHNFPPDHY	NCOA4	571	Q13772
VEPNEHYDPPFNISK	CEFIP	431	Q711Q0
HPPYGNEQTASFAPA	HOXB1	141	P14653
EPVHGAPFYFSLPNT	DSC3	601	Q14574
PPPRTHYSNIEANES	CAPNS1	81	P04632
VQSPAYHSPQEDPFL	GCM1	376	Q9NP62
DVDYATNPHVKPPYS	FOXJ1	111	Q92949
SPYPAPDHSNEDQEV	EFS	86	O43281
VLSQEPYQPQYPDSH	BRWD1	1086	Q9NSI6
YQEPFTHSAPESIPD	ME2	361	P23368
NPDSPSSNELIHYRP	MBD5	1366	Q9P267
FPYDPYDQPNSHTIE	LAMB4	76	A4D0S4
HVDYEPPNIVSPEDN	DZANK1	101	Q9NVP4
PEAFHYANNPRVTPL	ENPP7	316	Q6UWV6
YRVPSPRPDNSFHEN	CDKL5	716	O76039
LYSSQNEHAAPPSNP	CEP295	1671	Q9C0D2
HSPYQVSAPSDPLDI	KIR2DL1	106	P43626
PFSAAALQQHGYPEP	COL26A1	26	Q96A83
FQSRPEAGSEDYQPH	CREB3L4	316	Q8TEY5
AASQHPEYLVSPDPE	NOCT	86	Q9UK39
AQYPFEDHNPPQLEL	PTEN	86	P60484
NHAALPPTDYDRSPF	NR5A2	226	O00482
PQLQSETYLHPADPS	HSFX1	31	Q9UBD0
PHPYSDLADVFNPKE	RTL1	556	A6NKG5
YPPAQTHSEQSPADT	RBFOX1	66	Q9NWB1
QEPDSYPSEPIFVSH	RPE65	461	Q16518
FRYTDPHNPHSPFNT	LARS2	531	Q15031
HTDPNAEEAPENLPY	LIAT1	396	Q6ZQX7
PNPVGEEFHPTNHAY	NODAL	281	Q96S42
FPSQSDVHPLPAEGY	NFATC4	826	Q14934
SFSPNLDYHNPDIPE	SORCS3	1006	Q9UPU3
DDTFYLSNVAPQVPH	ENDOG	156	Q14249
PADSPTAPHIYAVFT	SEMA4A	311	Q9H3S1
IPFPDHNQSPRNTYQ	POLR2B	711	P30876
FYPESVFSDPIHNDP	ST3GAL6	166	Q9Y274
AQHDPPQSSFGPTQY	TRIOBP	956	Q9H2D6
PPNSQGFAPHYDDIE	RIOX1	331	Q9H6W3
YFLPEDTPQGRNSDH	ARID5B	76	Q14865
ADQDLLPSFHPYQPL	ANKHD1	761	Q8IWZ3
AVFANGIHPYPAQSP	CELF4	356	Q9BZC1
NQSTAYHFNPKPASP	CLUH	261	O75153
PDFEKNHCVPPYSES	DNTTIP2	611	Q5QJE6
SVGEEFYRNHSQPPP	SPART	196	Q8N0X7
EAVTADSRPHSPQYP	TYRP1	66	P17643
PQESDTLFYHAPPLS	ZBTB21	1021	Q9ULJ3
TYNQDNETLEVHPPP	PIGT	286	Q969N2
SDSYAHPLFDPRQPN	ROM1	231	Q03395
PPLDDYTHSIPENTN	SMAD2	191	Q15796
PPLDDYSHSIPENTN	SMAD3	151	P84022
QSTEQYDPFAEHRPP	SF3B1	96	O75533
LQPPSGTSHFEFPDY	SOX12	276	O15370
NPHASFSEEAYIPPQ	RNF123	576	Q5XPI4
SQEHPEADPGSAAPY	STAT3	691	P40763
FYDDAPPQDHFLTDP	SLC12A9	631	Q9BXP2
ATFPTQPDRPYDSNV	TEX52	106	A6NCN8
SRPQFDYSDHQPSGP	SOX10	396	P56693
SNVDPRDDVFGYPHQ	USP9Y	1611	O00507
PQPAPNLEDYHSRNS	nan	416	Q6ZUG5
QTYHQTPPPTFSFRE	ZDHHC16	246	Q969W1
HTYSQATFPGPLQPF	TRIM17	441	Q9Y577
HPNNFSRSPPYTDDV	ZSWIM8	1686	A7E2V4
YFAAPAQPDPDDQFI	PHLPP1	1651	O60346
HPTSLPEPDYSEFQS	TMC5	101	Q6UXY8
HALPAQVAFTPYAPE	TNFRSF1B	21	P20333
PDSPATPDLSHNQFF	PLD2	491	O14939
PTPDQNASPYHTIVD	ZP3	221	P21754
PNSFYEPHQDFTSPD	VRK2	426	Q86Y07
DYSQFHATFEVPTPP	KCNJ3	341	P48549
HRDTPENNPDTPFDF	NDUFV2	41	P19404
PHAYSAALEPFFESP	NEUROD1	246	Q13562
DNDHDPFPRYDPTNE	PCSK1	191	P29120