Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H	2.23e-05	3	55	2	GO:0008332
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC16 ZDHHC5 ZDHHC8	4.92e-05	26	55	3	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC16 ZDHHC5 ZDHHC8	4.92e-05	26	55	3	GO:0019707
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A CACNA1I CACNA1H	4.92e-05	26	55	3	GO:0005248
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F12 CYP4F11	7.41e-05	5	55	2	GO:0052871
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC16 ZDHHC5 ZDHHC8	7.62e-05	30	55	3	GO:0016417
GeneOntologyMolecularFunction	palmitoyltransferase activity	ZDHHC16 ZDHHC5 ZDHHC8	1.44e-04	37	55	3	GO:0016409
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F12 CYP4F11	1.55e-04	7	55	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F12 CYP4F11	1.55e-04	7	55	2	GO:0018685
GeneOntologyMolecularFunction	frizzled binding	WNT7A WNT7B CTHRC1	2.10e-04	42	55	3	GO:0005109
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F12 CYP4F11	3.31e-04	10	55	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F12 CYP4F11	3.31e-04	10	55	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F12 CYP4F11	3.31e-04	10	55	2	GO:0102033
GeneOntologyMolecularFunction	sodium channel activity	SCN11A CACNA1I CACNA1H	3.97e-04	52	55	3	GO:0005272
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	NMT2 ZDHHC16 ZDHHC5 ZDHHC8 SOAT1	4.94e-04	238	55	5	GO:0016747
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F12 CYP4F11	5.70e-04	13	55	2	GO:0016713
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1I CACNA1H	6.64e-04	14	55	2	GO:0008331
GeneOntologyMolecularFunction	arachidonate binding	CYP4F12 CYP4F11	7.64e-04	15	55	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F12 CYP4F11	8.72e-04	16	55	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F12 CYP4F11	8.72e-04	16	55	2	GO:0050543
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN11A CACNA1I CACNA1H ATP4A	1.26e-03	171	55	4	GO:0015081
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL28A1 CTHRC1 LAMC1 PAPLN	1.78e-03	188	55	4	GO:0005201
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F12 CYP4F11	1.98e-03	24	55	2	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F12 CYP4F11	2.50e-03	27	55	2	GO:0008391
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4F12 CYP4F11	2.69e-03	28	55	2	GO:0036041
GeneOntologyMolecularFunction	sphingolipid binding	LAPTM4B LAMC1	3.95e-03	34	55	2	GO:0046625
GeneOntologyMolecularFunction	aromatase activity	CYP4F12 CYP4F11	4.18e-03	35	55	2	GO:0070330
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP13A4 ATP4A	4.42e-03	36	55	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP13A4 ATP4A	4.42e-03	36	55	2	GO:0015662
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP4F12 CYP4F11	5.43e-03	40	55	2	GO:0016709
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1I CACNA1H	7.13e-03	46	55	2	GO:0005245
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP4F12 CYP4F11	8.06e-03	49	55	2	GO:0016712
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	ATP13A4 CACNA1I CACNA1H	8.34e-03	151	55	3	GO:0015085
GeneOntologyMolecularFunction	heme binding	HPX CYP4F12 CYP4F11	8.80e-03	154	55	3	GO:0020037
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	ATP13A4 SCN11A CACNA1I CACNA1H ATP4A	8.97e-03	465	55	5	GO:0046873
GeneOntologyBiologicalProcess	menaquinone catabolic process	CYP4F12 CYP4F11	2.09e-05	3	55	2	GO:0042361
GeneOntologyBiologicalProcess	menaquinone metabolic process	CYP4F12 CYP4F11	4.17e-05	4	55	2	GO:0009233
GeneOntologyBiologicalProcess	phylloquinone metabolic process	CYP4F12 CYP4F11	4.17e-05	4	55	2	GO:0042374
GeneOntologyBiologicalProcess	phylloquinone catabolic process	CYP4F12 CYP4F11	4.17e-05	4	55	2	GO:0042376
GeneOntologyBiologicalProcess	vitamin K catabolic process	CYP4F12 CYP4F11	4.17e-05	4	55	2	GO:0042377
GeneOntologyBiologicalProcess	central nervous system vasculogenesis	WNT7A WNT7B	6.95e-05	5	55	2	GO:0022009
GeneOntologyBiologicalProcess	protein palmitoylation	ZDHHC16 ZDHHC5 ZDHHC8	9.25e-05	33	55	3	GO:0018345
GeneOntologyBiologicalProcess	uterus morphogenesis	WNT7A NIPBL	1.04e-04	6	55	2	GO:0061038
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F12 CYP4F11	1.04e-04	6	55	2	GO:0036101
GeneOntologyBiologicalProcess	prostaglandin catabolic process	CYP4F12 CYP4F11	1.04e-04	6	55	2	GO:1905344
GeneOntologyBiologicalProcess	prostanoid catabolic process	CYP4F12 CYP4F11	1.04e-04	6	55	2	GO:0062232
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN11A CACNA1I CACNA1H	1.20e-04	36	55	3	GO:0086010
GeneOntologyBiologicalProcess	head development	EEF1AKMT4-ECE2 IGF1R WDR11 DYNC2H1 WNT7A WNT7B ZDHHC16 NDRG2 NIPBL BTBD3	1.38e-04	919	55	10	GO:0060322
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F12 CYP4F11	1.45e-04	7	55	2	GO:0036102
GeneOntologyBiologicalProcess	protein lipidation	NMT2 ZDHHC16 ZDHHC5 ZDHHC8	1.52e-04	101	55	4	GO:0006497
GeneOntologyBiologicalProcess	lipoprotein biosynthetic process	NMT2 ZDHHC16 ZDHHC5 ZDHHC8	1.84e-04	106	55	4	GO:0042158
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F12 CYP4F11	1.93e-04	8	55	2	GO:0036100
GeneOntologyBiologicalProcess	protein acylation	NMT2 ZDHHC16 ZDHHC5 ZDHHC8	1.97e-04	108	55	4	GO:0043543
GeneOntologyBiologicalProcess	vitamin K metabolic process	CYP4F12 CYP4F11	3.78e-04	11	55	2	GO:0042373
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F12 CYP4F11	3.78e-04	11	55	2	GO:1901523
GeneOntologyBiologicalProcess	brain development	EEF1AKMT4-ECE2 IGF1R DYNC2H1 WNT7A WNT7B ZDHHC16 NDRG2 NIPBL BTBD3	4.10e-04	859	55	9	GO:0007420
GeneOntologyBiologicalProcess	Wnt signaling pathway, planar cell polarity pathway	WNT7A WNT7B CTHRC1	4.27e-04	55	55	3	GO:0060071
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	CYP4F12 CYP4F11	4.53e-04	12	55	2	GO:0042758
GeneOntologyBiologicalProcess	fat-soluble vitamin catabolic process	CYP4F12 CYP4F11	4.53e-04	12	55	2	GO:0042363
GeneOntologyBiologicalProcess	regulation of cell projection size	WNT7A WNT7B	6.22e-04	14	55	2	GO:0032536
GeneOntologyBiologicalProcess	omega-hydroxylase P450 pathway	CYP4F12 CYP4F11	6.22e-04	14	55	2	GO:0097267
GeneOntologyBiologicalProcess	neuronal action potential	SCN11A CACNA1I CACNA1H	6.36e-04	63	55	3	GO:0019228
GeneOntologyBiologicalProcess	lipoprotein metabolic process	NMT2 ZDHHC16 ZDHHC5 ZDHHC8	6.37e-04	147	55	4	GO:0042157
GeneOntologyBiologicalProcess	positive regulation of osteoblast proliferation	IGF1R CTHRC1	7.17e-04	15	55	2	GO:0033690
GeneOntologyBiologicalProcess	positive regulation of regulated secretory pathway	CACNA1I CACNA1H IL4R	7.29e-04	66	55	3	GO:1903307
GeneOntologyBiologicalProcess	axonogenesis	SCN11A IGF1R PTPRZ1 WNT7A WNT7B LAMC1 USP33	7.32e-04	566	55	7	GO:0007409
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	SCN11A IGF1R PTPRZ1 WNT7A WNT7B LAMC1 BTBD3 USP33	7.76e-04	748	55	8	GO:0048667
GeneOntologyBiologicalProcess	regulation of regulated secretory pathway	WNT7A CACNA1I CACNA1H IL4R	9.80e-04	165	55	4	GO:1903305
GeneOntologyBiologicalProcess	exocytosis	EXOC6 SCN11A WNT7A CACNA1I CACNA1H IL4R	1.02e-03	434	55	6	GO:0006887
GeneOntologyBiologicalProcess	lens fiber cell development	WNT7A WNT7B	1.04e-03	18	55	2	GO:0070307
GeneOntologyBiologicalProcess	vitamin catabolic process	CYP4F12 CYP4F11	1.04e-03	18	55	2	GO:0009111
GeneOntologyBiologicalProcess	regulated exocytosis	SCN11A WNT7A CACNA1I CACNA1H IL4R	1.06e-03	291	55	5	GO:0045055
GeneOntologyCellularComponent	tertiary granule lumen	OLFM4 CRISP3 CHIT1 MMP9 LYZ	3.29e-07	55	55	5	GO:1904724
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN11A CACNA1I CACNA1H	1.14e-05	17	55	3	GO:0001518
GeneOntologyCellularComponent	specific granule lumen	OLFM4 CRISP3 CHIT1 LYZ	2.14e-05	62	55	4	GO:0035580
GeneOntologyCellularComponent	extracellular matrix	PTPRZ1 COL28A1 WNT7A HPX CTHRC1 LAMC1 PAPLN CRISP3 MMP9	4.89e-05	656	55	9	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	PTPRZ1 COL28A1 WNT7A HPX CTHRC1 LAMC1 PAPLN CRISP3 MMP9	5.00e-05	658	55	9	GO:0030312
GeneOntologyCellularComponent	sodium channel complex	SCN11A CACNA1I CACNA1H	6.00e-05	29	55	3	GO:0034706
GeneOntologyCellularComponent	tertiary granule	OLFM4 CRISP3 CHIT1 MMP9 LYZ	7.09e-05	164	55	5	GO:0070820
GeneOntologyCellularComponent	collagen-containing extracellular matrix	PTPRZ1 COL28A1 HPX CTHRC1 LAMC1 PAPLN MMP9	4.58e-04	530	55	7	GO:0062023
GeneOntologyCellularComponent	site of polarized growth	EXOC6 SCN11A PTPRZ1 FRYL NDRG2	5.30e-04	253	55	5	GO:0030427
GeneOntologyCellularComponent	specific granule	OLFM4 CRISP3 CHIT1 LYZ	8.32e-04	160	55	4	GO:0042581
GeneOntologyCellularComponent	endoplasmic reticulum lumen	COL28A1 WNT7A WNT7B LAMC1 LYZ	1.78e-03	332	55	5	GO:0005788
HumanPheno	Aplasia/hypoplasia involving forearm bones	DYNC2H1 WNT7A RECQL4 MMP9 NIPBL	1.35e-05	100	17	5	HP:0006503
HumanPheno	Carpal bone aplasia	WNT7A RECQL4	6.27e-05	4	17	2	HP:0004231
HumanPheno	Forearm undergrowth	DYNC2H1 WNT7A RECQL4 NIPBL	8.92e-05	75	17	4	HP:0009821
HumanPheno	Short foot	IGF1R DYNC2H1 WNT7A RECQL4 NIPBL	1.06e-04	153	17	5	HP:0001773
HumanPheno	Short feet	IGF1R DYNC2H1 WNT7A RECQL4 NIPBL	1.06e-04	153	17	5	HP:0001766
HumanPheno	Small feet	IGF1R DYNC2H1 WNT7A RECQL4 NIPBL	1.06e-04	153	17	5	HP:0001764
HumanPheno	Aplasia/Hypoplasia of the radius	WNT7A RECQL4 MMP9 NIPBL	1.27e-04	82	17	4	HP:0006501
HumanPheno	Abnormal morphology of ulna	DYNC2H1 WNT7A RECQL4 MMP9 NIPBL	1.27e-04	159	17	5	HP:0040071
HumanPheno	Abnormality of the ulna	DYNC2H1 WNT7A RECQL4 MMP9 NIPBL	1.27e-04	159	17	5	HP:0002997
HumanPheno	Upper limb undergrowth	DYNC2H1 WNT7A RECQL4 NIPBL	1.52e-04	86	17	4	HP:0009824
HumanPheno	Talipes equinovalgus	IGF1R DYNC2H1 WNT7A RECQL4 NIPBL	1.56e-04	166	17	5	HP:0001772
HumanPheno	Oligodactyly	WNT7A RECQL4 NIPBL	1.58e-04	33	17	3	HP:0012165
HumanPheno	Micromelia	DYNC2H1 WNT7A MMP9 NIPBL	2.15e-04	94	17	4	HP:0002983
HumanPheno	Broad foot	IGF1R DYNC2H1 WNT7A RECQL4 NIPBL	2.22e-04	179	17	5	HP:0001769
HumanPheno	Abnormal forearm bone morphology	DYNC2H1 WNT7A RECQL4 MMP9 NIPBL	2.40e-04	182	17	5	HP:0040073
HumanPheno	Phocomelia	WNT7A NIPBL	2.90e-04	8	17	2	HP:0009829
HumanPheno	Hypoplasia of the radius	WNT7A RECQL4 NIPBL	3.51e-04	43	17	3	HP:0002984
HumanPheno	Abnormal ulnar metaphysis morphology	RECQL4 MMP9	4.64e-04	10	17	2	HP:0004039
Domain	Wnt7	WNT7A WNT7B	8.21e-06	2	54	2	IPR013300
Domain	VDCC_T_a1	CACNA1I CACNA1H	2.46e-05	3	54	2	IPR005445
Domain	zf-DHHC	ZDHHC16 ZDHHC5 ZDHHC8	3.88e-05	23	54	3	PF01529
Domain	DHHC	ZDHHC16 ZDHHC5 ZDHHC8	5.02e-05	25	54	3	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC16 ZDHHC5 ZDHHC8	5.02e-05	25	54	3	IPR001594
Domain	VDCCAlpha1	CACNA1I CACNA1H	3.64e-04	10	54	2	IPR002077
Domain	Quinoprot_gluc/sorb_DH	OLFM4 HHIPL1	5.32e-04	12	54	2	IPR011041
Domain	Channel_four-helix_dom	SCN11A CACNA1I CACNA1H	5.99e-04	57	54	3	IPR027359
Domain	-	SCN11A CACNA1I CACNA1H	5.99e-04	57	54	3	1.20.120.350
Domain	Hemopexin_CS	HPX MMP9	1.09e-03	17	54	2	IPR018486
Domain	Cation_ATPase_N	ATP13A4 ATP4A	1.22e-03	18	54	2	PF00690
Domain	Cation_ATPase_N	ATP13A4 ATP4A	1.22e-03	18	54	2	SM00831
Domain	-	COL28A1 PAPLN	1.22e-03	18	54	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	COL28A1 PAPLN	1.22e-03	18	54	2	IPR020901
Domain	KU	COL28A1 PAPLN	1.22e-03	18	54	2	SM00131
Domain	Wnt	WNT7A WNT7B	1.36e-03	19	54	2	IPR005817
Domain	Wnt_CS	WNT7A WNT7B	1.36e-03	19	54	2	IPR018161
Domain	wnt	WNT7A WNT7B	1.36e-03	19	54	2	PF00110
Domain	BPTI_KUNITZ_2	COL28A1 PAPLN	1.36e-03	19	54	2	PS50279
Domain	ATPase_P-typ_cation-transptr_N	ATP13A4 ATP4A	1.36e-03	19	54	2	IPR004014
Domain	Kunitz_BPTI	COL28A1 PAPLN	1.36e-03	19	54	2	PF00014
Domain	WNT1	WNT7A WNT7B	1.36e-03	19	54	2	SM00097
Domain	WNT1	WNT7A WNT7B	1.36e-03	19	54	2	PS00246
Domain	BPTI_KUNITZ_1	COL28A1 PAPLN	1.36e-03	19	54	2	PS00280
Domain	Hemopexin-like_dom	HPX MMP9	2.00e-03	23	54	2	IPR000585
Domain	Hemopexin-like_repeat	HPX MMP9	2.00e-03	23	54	2	IPR018487
Domain	Hemopexin	HPX MMP9	2.00e-03	23	54	2	PF00045
Domain	HEMOPEXIN	HPX MMP9	2.00e-03	23	54	2	PS00024
Domain	-	HPX MMP9	2.00e-03	23	54	2	2.110.10.10
Domain	HEMOPEXIN_2	HPX MMP9	2.00e-03	23	54	2	PS51642
Domain	Kunitz_BPTI	COL28A1 PAPLN	2.00e-03	23	54	2	IPR002223
Domain	HX	HPX MMP9	2.00e-03	23	54	2	SM00120
Domain	-	ATP13A4 ATP4A	3.85e-03	32	54	2	3.40.1110.10
Domain	-	ATP13A4 ATP4A	3.85e-03	32	54	2	2.70.150.10
Domain	Ion_trans_dom	SCN11A CACNA1I CACNA1H	4.38e-03	114	54	3	IPR005821
Domain	Ion_trans	SCN11A CACNA1I CACNA1H	4.38e-03	114	54	3	PF00520
Domain	ATPase_P-typ_cyto_domN	ATP13A4 ATP4A	4.59e-03	35	54	2	IPR023299
Domain	P_typ_ATPase	ATP13A4 ATP4A	4.85e-03	36	54	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP13A4 ATP4A	4.85e-03	36	54	2	IPR018303
Domain	ATPASE_E1_E2	ATP13A4 ATP4A	4.85e-03	36	54	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP13A4 ATP4A	5.12e-03	37	54	2	IPR008250
Domain	E1-E2_ATPase	ATP13A4 ATP4A	5.12e-03	37	54	2	PF00122
Domain	Cyt_P450_E_grp-I	CYP4F12 CYP4F11	7.50e-03	45	54	2	IPR002401
Pathway	PID_WNT_SIGNALING_PATHWAY	WNT7A WNT7B CTHRC1	8.80e-05	28	44	3	M77
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TNRC18 IGF1R KLHL21 WNT7B ZDHHC5 PAPLN CACNA1H HMGXB3 FRYL MED13L ZDHHC8 IL4R	1.89e-07	1105	57	12	35748872
Pubmed	Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.	ZDHHC16 ZDHHC5 ZDHHC8	2.30e-06	16	57	3	23034182
Pubmed	Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain.	IGF1R WNT7A WNT7B	2.30e-06	16	57	3	22625652
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	2.64e-06	2	57	2	12808460
Pubmed	Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response.	LYZ IL4R	2.64e-06	2	57	2	23532373
Pubmed	Olfactomedin 4 suppresses tumor growth and metastasis of mouse melanoma cells through downregulation of integrin and MMP genes.	OLFM4 MMP9	2.64e-06	2	57	2	23161172
Pubmed	Suppression of MMP-9 activity by NDRG2 expression inhibits clear cell renal cell carcinoma invasion.	MMP9 NDRG2	2.64e-06	2	57	2	22692967
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	2.64e-06	2	57	2	25071191
Pubmed	Recruitment of M1 Macrophages May Not Be Critical for Protection against Colitis-Associated Tumorigenesis.	LYZ IL4R	2.64e-06	2	57	2	34681866
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	2.64e-06	2	57	2	36786913
Pubmed	Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.	LYZ IL4R	2.64e-06	2	57	2	15142530
Pubmed	Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells.	CTHRC1 MMP9	2.64e-06	2	57	2	24504172
Pubmed	Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling.	LYZ IL4R	2.64e-06	2	57	2	33164548
Pubmed	Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.	ZDHHC5 ZDHHC8	2.64e-06	2	57	2	25049274
Pubmed	M2 Macrophages promote IL-33 expression, ILC2 expansion and mucous metaplasia in response to early life rhinovirus infections.	LYZ IL4R	2.64e-06	2	57	2	36032072
Pubmed	BALB/c mice deficient in CD4 T cell IL-4Rα expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype.	LYZ IL4R	2.64e-06	2	57	2	21245915
Pubmed	Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism.	OLFM4 MMP9	2.64e-06	2	57	2	37151883
Pubmed	IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice.	LYZ IL4R	2.64e-06	2	57	2	25790379
Pubmed	Allergic airway disease is unaffected by the absence of IL-4Rα-dependent alternatively activated macrophages.	LYZ IL4R	2.64e-06	2	57	2	22552110
Pubmed	Expression patterns of T-type Cav3.2 channel and insulin-like growth factor-1 receptor in dorsal root ganglion neurons of mice after sciatic nerve axotomy.	IGF1R CACNA1H	2.64e-06	2	57	2	27571431
Pubmed	WNT7A/B promote choroidal neovascularization.	WNT7A WNT7B	2.64e-06	2	57	2	29864439
Pubmed	CD4+ T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism.	LYZ IL4R	2.64e-06	2	57	2	17709489
Pubmed	Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.	LYZ IL4R	7.91e-06	3	57	2	32814028
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H	7.91e-06	3	57	2	23488970
Pubmed	Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response.	LYZ IL4R	7.91e-06	3	57	2	17330244
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H	7.91e-06	3	57	2	11230107
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H	7.91e-06	3	57	2	33547341
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H	7.91e-06	3	57	2	28972185
Pubmed	Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E-Deficient Mice.	IGF1R LYZ	7.91e-06	3	57	2	27154724
Pubmed	Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice.	LYZ IL4R	7.91e-06	3	57	2	16394000
Pubmed	A common framework of monocyte-derived macrophage activation.	LYZ IL4R	7.91e-06	3	57	2	35427180
Pubmed	Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.	LYZ IL4R	7.91e-06	3	57	2	26474656
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H	7.91e-06	3	57	2	11897840
Pubmed	CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9.	CTHRC1 MMP9	7.91e-06	3	57	2	29631554
Pubmed	Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.	ZDHHC5 ZDHHC8	7.91e-06	3	57	2	22325201
Pubmed	Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.	ZDHHC5 ZDHHC8	7.91e-06	3	57	2	19801377
Pubmed	Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.	EEF1AKMT4-ECE2 EEF1AKMT4	7.91e-06	3	57	2	28520920
Pubmed	Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.	LYZ SOAT1	7.91e-06	3	57	2	29533741
Pubmed	The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells.	HPX MMP9	7.91e-06	3	57	2	29761931
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H	7.91e-06	3	57	2	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H	7.91e-06	3	57	2	18591418
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H	7.91e-06	3	57	2	28846697
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H	7.91e-06	3	57	2	11927664
Pubmed	GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.	WNT7A WNT7B	7.91e-06	3	57	2	25558062
Pubmed	Free heme exacerbates colonic injury induced by anti-cancer therapy.	HPX LYZ	7.91e-06	3	57	2	37342339
Pubmed	Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z.	PTPRZ1 MMP9	7.91e-06	3	57	2	18713734
Pubmed	Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice.	MMP9 IL4R	7.91e-06	3	57	2	14707083
Pubmed	Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.	LYZ IL4R	7.91e-06	3	57	2	34326406
Pubmed	Bone morphogenetic protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast cancer cells.	MMP9 NDRG2	7.91e-06	3	57	2	19450561
Pubmed	Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions.	LYZ SOAT1	7.91e-06	3	57	2	31495784
Pubmed	Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease.	WNT7A WNT7B MMP9	1.06e-05	26	57	3	37982452
Pubmed	Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation.	WNT7B MMP9 LYZ	1.06e-05	26	57	3	20978081
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F12 CYP4F11	1.58e-05	4	57	2	22665481
Pubmed	An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.	LYZ IL4R	1.58e-05	4	57	2	23426944
Pubmed	HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection.	LYZ IL4R	1.58e-05	4	57	2	37902285
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H	1.58e-05	4	57	2	28165634
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F12 CYP4F11	1.58e-05	4	57	2	11185557
Pubmed	Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype.	IGF1R LYZ	1.58e-05	4	57	2	30718296
Pubmed	IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.	LYZ IL4R	1.58e-05	4	57	2	29463471
Pubmed	Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock.	LYZ IL4R	1.58e-05	4	57	2	33767712
Pubmed	Recruitment of hepatic macrophages from monocytes is independent of IL-4Rα but is associated with ablation of resident macrophages in schistosomiasis.	LYZ IL4R	1.58e-05	4	57	2	30919955
Pubmed	Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts.	MMP9 LYZ	1.58e-05	4	57	2	27090492
Pubmed	IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.	IGF1R LYZ	1.58e-05	4	57	2	28402847
Pubmed	Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.	MMP9 LYZ	1.58e-05	4	57	2	22496659
Pubmed	IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.	LYZ IL4R	1.58e-05	4	57	2	24101381
Pubmed	A molecular mechanism for Wnt ligand-specific signaling.	WNT7A WNT7B	1.58e-05	4	57	2	30026314
Pubmed	Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.	LYZ SOAT1	1.58e-05	4	57	2	26801614
Pubmed	Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation.	LYZ IL4R	1.58e-05	4	57	2	36052067
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F12 CYP4F11	1.58e-05	4	57	2	18065749
Pubmed	Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice.	LYZ IL4R	1.58e-05	4	57	2	36077870
Pubmed	Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.	LYZ IL4R	1.58e-05	4	57	2	25981357
Pubmed	BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.	WNT7A WNT7B MMP9	2.41e-05	34	57	3	18927151
Pubmed	Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release.	WNT7A WNT7B	2.63e-05	5	57	2	16818724
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F12 CYP4F11	2.63e-05	5	57	2	22969154
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F12 CYP4F11	2.63e-05	5	57	2	21466787
Pubmed	Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.	LYZ IL4R	2.63e-05	5	57	2	22101429
Pubmed	NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.	EXOC6 NDRG2	2.63e-05	5	57	2	23435566
Pubmed	A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury.	OLFM4 LYZ	2.63e-05	5	57	2	37669929
Pubmed	Eosinophils secrete IL-4 to facilitate liver regeneration.	LYZ IL4R	2.63e-05	5	57	2	23716700
Pubmed	Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.	LYZ IL4R	2.63e-05	5	57	2	17016559
Pubmed	Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2.	WNT7A WNT7B	2.63e-05	5	57	2	12843296
Pubmed	Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.	LYZ IL4R	2.63e-05	5	57	2	28687632
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	EEF1AKMT4-ECE2 ATP13A4 ZDHHC16 OLFM4 CTHRC1 PAPLN CYP4F12 HHIPL1 LHFPL1	3.00e-05	985	57	9	12975309
Pubmed	Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?	SCN11A CACNA1H	3.94e-05	6	57	2	17513486
Pubmed	Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members.	WNT7A WNT7B	3.94e-05	6	57	2	9671940
Pubmed	IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells.	LYZ IL4R	3.94e-05	6	57	2	30610060
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F12 CYP4F11	3.94e-05	6	57	2	9068972
Pubmed	Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland.	WNT7A WNT7B	3.94e-05	6	57	2	1373817
Pubmed	microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development.	PTPRZ1 CTHRC1	3.94e-05	6	57	2	25369991
Pubmed	Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.	WNT7A WNT7B	3.94e-05	6	57	2	8168088
Pubmed	A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles.	LYZ IL4R	3.94e-05	6	57	2	29627423
Pubmed	Tissue-specific signals control reversible program of localization and functional polarization of macrophages.	LYZ IL4R	3.94e-05	6	57	2	24792964
Pubmed	Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.	WNT7A WNT7B	3.94e-05	6	57	2	33086038
Pubmed	USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.	CEP97 USP33	3.94e-05	6	57	2	23486064
Pubmed	Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.	WNT7A WNT7B	5.51e-05	7	57	2	30478038
Pubmed	Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.	CYP4F12 CYP4F11	5.51e-05	7	57	2	22160543
Pubmed	The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.	IGF1R TEC	5.51e-05	7	57	2	2482828
Pubmed	Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family.	WNT7A WNT7B	5.51e-05	7	57	2	8058323
Pubmed	Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver.	LYZ IL4R	5.51e-05	7	57	2	28495878
Pubmed	Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.	LYZ IL4R	5.51e-05	7	57	2	24906148
Cytoband	Ensembl 112 genes in cytogenetic band chr4p11	FRYL TEC	2.55e-04	19	57	2	chr4p11
Cytoband	14q24.2	PAPLN ZFYVE1	4.46e-04	25	57	2	14q24.2
Cytoband	19p13.1	CYP4F12 CYP4F11	1.65e-03	48	57	2	19p13.1
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC16 ZDHHC5 ZDHHC8	1.68e-05	24	38	3	76
GeneFamily	Wnt family\|Endogenous ligands	WNT7A WNT7B	7.19e-04	19	38	2	360
GeneFamily	Calcium voltage-gated channel subunits	CACNA1I CACNA1H	1.35e-03	26	38	2	253
GeneFamily	Cytochrome P450 family 4	CYP4F12 CYP4F11	2.59e-03	36	38	2	1003
Coexpression	ALK_DN.V1_DN	PTPRZ1 HPX OLFM4 NDRG2 GPR162	1.20e-05	139	56	5	M2773
Coexpression	BOYLAN_MULTIPLE_MYELOMA_C_D_DN	IGF1R OLFM4 CACNA1H CRISP3 MMP9 LYZ	4.45e-05	302	56	6	MM1046
Coexpression	HOWARD_PBMC_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_19_39YO_AS03_ADJUVANT_VS_BUFFER_1DY_DN	ATP13A4 CACNA1I CYP4F12	5.76e-05	35	56	3	M40938
Coexpression	DESCARTES_ORGANOGENESIS_NUETROPHILS	OLFM4 MMP9 LYZ	6.27e-05	36	56	3	MM3668
Coexpression	GSE15930_NAIVE_VS_72H_IN_VITRO_STIM_TRICHOSTATINA_CD8_TCELL_UP	KLHL21 WNT7B ZDHHC5 TEC ZNF292	6.85e-05	200	56	5	M3614
Coexpression	GSE40274_XBP1_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	IGF1R LAMC1 TKTL1 TEC IL4R	6.85e-05	200	56	5	M9161
ToppCell	wk_15-18-Hematologic-Myeloid-Myelocyte-like\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SCN11A OLFM4 CRISP3 CHIT1 MMP9 LYZ	1.36e-07	185	57	6	92b9ec18ff7c53a52b87e2c2012d0b719a7ad20a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGF1R OLFM4 CRISP3 CHIT1 MMP9 LYZ	1.54e-07	189	57	6	3b35022c0619df6db234613aa53a076899ca9562
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGF1R OLFM4 CRISP3 CHIT1 MMP9 LYZ	1.54e-07	189	57	6	358ff514f1c8aa46067208ddf1b68396d789c130
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNRC18 OLFM4 CRISP3 CHIT1 MMP9 LYZ	1.85e-07	195	57	6	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	OLFM4 CRISP3 CHIT1 MMP9 LYZ IL4R	2.09e-07	199	57	6	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	OLFM4 CRISP3 CHIT1 MMP9 LYZ	3.92e-06	185	57	5	d747bc91fc276f12a5572ab0223fc71f829a5110
ToppCell	wk_20-22-Hematologic-Myeloid-Myelocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.02e-06	186	57	5	53b4ce33ae6fa32f1b56cbc62b1d7915e935afc9
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LAPTM4B OLFM4 CRISP3 CHIT1 MMP9	4.24e-06	188	57	5	557a0ac069a6ff4e687cac032f64170b9b247165
ToppCell	PBMC-Severe-Myeloid-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.46e-06	190	57	5	cb62ece5929896dfba30a4f563c6ba5a5712b71e
ToppCell	PBMC-Severe-Myeloid-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.46e-06	190	57	5	fedd266198d294d8da8c9e217e5e0cb8b2e1b566
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.46e-06	190	57	5	896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCell	COVID-19_Severe-Myeloid_G\|COVID-19_Severe / Disease group, lineage and cell class	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.46e-06	190	57	5	8a81cb90273c361e9fdfaa0a31806da253fa1388
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.58e-06	191	57	5	6c1283d51a845cff67ed5e500f7e944165297b53
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.70e-06	192	57	5	86d561c30554ff04c21801d4aaf8e3c9efe49af4
ToppCell	COVID-19_Severe-Myeloid_G-immature_Neutrophil\|COVID-19_Severe / Disease group, lineage and cell class	OLFM4 CRISP3 CHIT1 MMP9 LYZ	4.70e-06	192	57	5	303deb68da2e4a75e6ee5a79478182a8bc41c7c5
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TNRC18 OLFM4 CRISP3 CHIT1 MMP9	4.82e-06	193	57	5	e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCell	COVID_vent-Myeloid-Monocytic-Developing_Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	OLFM4 CRISP3 CHIT1 MMP9 LYZ	5.07e-06	195	57	5	de23409b1b4146b8ae286850b829ec8dceed0117
ToppCell	COVID-19_Severe-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	OLFM4 CRISP3 CHIT1 MMP9 LYZ	5.19e-06	196	57	5	16359a56297f0558fc93fa52563cce0c53def167
ToppCell	COVID-19_Severe-Neu_2\|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients	OLFM4 CRISP3 CHIT1 MMP9 LYZ	5.32e-06	197	57	5	945f19475905cdedf232315eea1076ca0b753b67
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	OLFM4 CRISP3 CHIT1 MMP9 LYZ	5.46e-06	198	57	5	3bc05b8d97a7219af40db7a11aa271f02e74fca5
ToppCell	COVID-19_Severe-immature_Neutrophil\|COVID-19_Severe / Disease condition and Cell class	IGF1R OLFM4 CRISP3 CHIT1 MMP9	5.59e-06	199	57	5	f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCell	COVID-19_Severe-immature_Neutrophil-\|COVID-19_Severe / Disease condition and Cell class	IGF1R OLFM4 CRISP3 CHIT1 MMP9	5.59e-06	199	57	5	42ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	OLFM4 CRISP3 CHIT1 MMP9 LYZ	5.59e-06	199	57	5	caf2e050b21e7a16ce4e51b3f135debd06810231
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FRYL SAMHD1 MED13L NIPBL ZNF292	5.73e-06	200	57	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPRZ1 COL28A1 CRISP3 LYZ NDRG2	5.73e-06	200	57	5	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	severe-immature_Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IGF1R CRISP3 CHIT1 MMP9 LYZ	5.73e-06	200	57	5	5ee43386da8261d2e7602a152e6ba4338d844e08
ToppCell	severe-immature_Neutrophil\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IGF1R CRISP3 CHIT1 MMP9 LYZ	5.73e-06	200	57	5	a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|390C / Donor, Lineage, Cell class and subclass (all cells)	TNRC18 WNT7B TKTL1 ZFYVE1	1.25e-05	111	57	4	dfbdeadad321392d359e6fb7112b28b043a4b874
ToppCell	COVID-19_Mild-immature_Neutrophil\|COVID-19_Mild / Disease condition and Cell class	RECQL4 OLFM4 CRISP3 CHIT1	1.88e-05	123	57	4	a6670825fd8d9f9a0111a7b68598c764c99abb0d
ToppCell	COVID-19_Mild-immature_Neutrophil-\|COVID-19_Mild / Disease condition and Cell class	RECQL4 OLFM4 CRISP3 CHIT1	1.88e-05	123	57	4	5f19b0e32509bedeb9ac6c74ac7a20750798da5e
ToppCell	PBMC-Mild-Myeloid-Neutrophil\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OLFM4 CRISP3 CHIT1 MMP9	2.41e-05	131	57	4	fdec4e31ffeb02615ccb7097758a8218dd1f8c1c
ToppCell	COVID-19_Mild-Myeloid_G\|COVID-19_Mild / Disease group, lineage and cell class	OLFM4 CRISP3 CHIT1 MMP9	3.30e-05	142	57	4	c8aeb747ed836197265d269aa131fae172b45aec
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OLFM4 CRISP3 CHIT1 MMP9	3.39e-05	143	57	4	9836a040a2ebcf6f05431e658a7b8fd566621452
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OLFM4 CRISP3 CHIT1 MMP9	3.39e-05	143	57	4	4622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCell	PBMC-Mild-Myeloid-Neutrophil\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	OLFM4 CRISP3 CHIT1 MMP9	3.39e-05	143	57	4	974260c25dad599eea83a33e83117f7307b92a42
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	OLFM4 LAMC1 CRISP3 CHIT1	3.98e-05	149	57	4	e9974260a5f2999b363f306cae005698c912893a
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL28A1 HPX CTHRC1 HHIPL1	4.88e-05	157	57	4	8d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell	facs-Heart-Unknown-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL28A1 HPX CTHRC1 HHIPL1	4.88e-05	157	57	4	2ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL28A1 HPX CTHRC1 HHIPL1	4.88e-05	157	57	4	8a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1H TKTL1 GPR162 CEP97	5.65e-05	163	57	4	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1H TKTL1 GPR162 CEP97	5.65e-05	163	57	4	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1H TKTL1 GPR162 CEP97	5.78e-05	164	57	4	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1H TKTL1 GPR162 CEP97	5.78e-05	164	57	4	a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NOL4 COL28A1 PANX2 NDRG2	6.20e-05	167	57	4	55c3c68af269fcf40f2b080ae4489523609ad388
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRZ1 WNT7A CACNA1H BTBD3	6.65e-05	170	57	4	14aa86a4f526ed6986afcb28c49225522055550c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OLFM4 CRISP3 CHIT1 LYZ	6.65e-05	170	57	4	cf22a843ae2d9cd6693507fed2b7c6a45abea10e
ToppCell	healthy_donor-Myeloid-Monocytic-Developing_Neutrophil\|healthy_donor / Disease condition, Lineage, Cell class and subclass	RECQL4 OLFM4 CRISP3 CHIT1	6.65e-05	170	57	4	cfd7f29805b7c51666b0eaf269c36c96b8765a1a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PAPLN CYP4F12 CYP4F11	7.27e-05	174	57	4	53c2c132566a7682f3268c7f9138700f09c3b94d
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRZ1 COL28A1 SAMHD1 NDRG2	7.27e-05	174	57	4	667035a11b68745fa8446d6c68214713be42710f
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRZ1 WNT7A CACNA1H BTBD3	7.60e-05	176	57	4	05ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 PTPRZ1 NDRG2 SOAT1	7.60e-05	176	57	4	ac3dc44755280e36c0947b6de3cd639dc17de8b6
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRZ1 WNT7B CTHRC1 CACNA1I	7.94e-05	178	57	4	4289e435d465b7a1490d13bf05278f4ed77d69cd
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OLFM4 CRISP3 CHIT1 LYZ	8.12e-05	179	57	4	e1bfd553c043ebc070ccf8545d489ba16d9b2ef4
ToppCell	10x5'-GI_large-bowel-Myeloid_Dendritic\|GI_large-bowel / Manually curated celltypes from each tissue	SAMHD1 LYZ NDRG2 BTBD3	8.29e-05	180	57	4	400f48aa2851d89bf3b60d721bc0f635f3ad86eb
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAPTM4B PAPLN NDRG2 ATP4A	8.29e-05	180	57	4	0b653b1b653b40f3b8711d1312029a4a8a4961db
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRZ1 COL28A1 SAMHD1 NDRG2	8.29e-05	180	57	4	38490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCell	10x5'-GI_large-bowel-Myeloid_Dendritic-DC2\|GI_large-bowel / Manually curated celltypes from each tissue	SAMHD1 LYZ NDRG2 BTBD3	8.29e-05	180	57	4	d4ebe67a2735e244c08b238320bbb441ca88ee6f
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	OLFM4 CRISP3 CHIT1 IL4R	8.66e-05	182	57	4	52eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDRG2 GPR162 ATP4A LHFPL1	8.84e-05	183	57	4	f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Serous\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL28A1 CRISP3 LYZ NDRG2	9.03e-05	184	57	4	f0cbb5b76e092be4188a9804ef5cf7a83cd7644f
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD163+CD14+_DCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	SAMHD1 MMP9 LYZ NDRG2	9.03e-05	184	57	4	2dc4b2a9970111ed5e2977fc178595a12d7bb59d
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Serous-Serous\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL28A1 CRISP3 LYZ NDRG2	9.03e-05	184	57	4	5433ba7bbab553ff668619822d1a9208e15cd59f
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRZ1 WNT7B CTHRC1 CACNA1I	9.03e-05	184	57	4	5b0695b1fbc8e4230f8f0669373ea10af82a0130
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRZ1 WNT7B CTHRC1 CACNA1I	9.03e-05	184	57	4	6485d0d34bdab337b747c0ea2d75e8fad8486b4d
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDRG2 GPR162 ATP4A LHFPL1	9.03e-05	184	57	4	8939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PAPLN CYP4F12 CYP4F11	9.03e-05	184	57	4	22c18964818fc9c8f18051f836d718937b0d8d12
ToppCell	10x5'v1-week_17-19-Myeloid_monocytic-monocyte-MOP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RECQL4 PACS2 SAMHD1 LYZ	9.22e-05	185	57	4	d1c4fc794c2bd8187abf8f45dc76ba474c40daae
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PAPLN NDRG2 CYP4F11	9.41e-05	186	57	4	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRZ1 COL28A1 SAMHD1 NDRG2	9.41e-05	186	57	4	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PAPLN NDRG2 CYP4F11	9.61e-05	187	57	4	2b1b2c3792d6c9ab69675ce88842bb589414b530
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	EXOC6 IGF1R LAPTM4B CACNA1I	9.61e-05	187	57	4	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	P03-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PTPRZ1 CTHRC1 NDRG2 BTBD3	1.00e-04	189	57	4	b5439ef221106f6d54434f268485e9bb17b39102
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	OLFM4 CRISP3 CHIT1 LYZ	1.00e-04	189	57	4	94dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PAPLN NDRG2 CYP4F11	1.02e-04	190	57	4	78cc6c28b31de041c24175a98f47da256ecc15a2
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT7B LAPTM4B NDRG2 ATP4A	1.02e-04	190	57	4	c247562df3e1aa3173c9f01a74d5831f0764a1b2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PTPRZ1 PAPLN NDRG2	1.02e-04	190	57	4	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PAPLN NDRG2 CYP4F11	1.02e-04	190	57	4	e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCell	control-Myeloid-Immature_Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	OLFM4 CRISP3 CHIT1 LYZ	1.02e-04	190	57	4	38e83337c70c8734b63f8589ba59e0f98603f94c
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT7B LAPTM4B NDRG2 ATP4A	1.02e-04	190	57	4	5cea8298c8336c136ba009630c9e48d4bc832cb2
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL28A1 CRISP3 LYZ NDRG2	1.04e-04	191	57	4	13460059a0c1ed9f476cef28b8ad4c06349056c6
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	OLFM4 CRISP3 CHIT1 MMP9	1.04e-04	191	57	4	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 PTPRZ1 WNT7A NDRG2	1.04e-04	191	57	4	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP13A4 PTPRZ1 NDRG2 SOAT1	1.06e-04	192	57	4	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	control-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	OLFM4 CRISP3 CHIT1 LYZ	1.06e-04	192	57	4	9f12b79d661ef0f57c2c924e8ecc24a46ea996d2
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PTPRZ1 PAPLN NDRG2	1.09e-04	193	57	4	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ATP13A4 PTPRZ1 PAPLN NDRG2	1.09e-04	193	57	4	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OLFM4 CRISP3 CHIT1 LYZ	1.09e-04	193	57	4	ccab6a0c76f574ef7e1d6d5f1e620376daf21bbf
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAPTM4B NDRG2 GPR162 ATP4A	1.09e-04	193	57	4	b397c14ac1e34c6be3f25d4417d200bc518d3048
ToppCell	NS-critical-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPRZ1 WNT7B LAPTM4B CYP4F12	1.11e-04	194	57	4	2172d951896265243d14996eacce5aab5e14e26e
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OLFM4 CRISP3 CHIT1 LYZ	1.11e-04	194	57	4	23318a1b55895b5166c6151f488a94a09b4627ff
ToppCell	Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SAMHD1 CHIT1 LYZ SOAT1	1.13e-04	195	57	4	eb104f3bb08ab9eca31273c0523a5c90de1f30a9
ToppCell	severe-Myeloid-Immature_Neutrophils_1\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	OLFM4 CRISP3 CHIT1 LYZ	1.13e-04	195	57	4	becad890a420267ca41e98e61a8da343b51e1945
ToppCell	wk_08-11-Hematologic-Myeloid-Myelocyte-like\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TEC CHIT1 MMP9 LYZ	1.15e-04	196	57	4	4b88c96b737a747422674ad99c073b28e6febc7c
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTPRZ1 COL28A1 SAMHD1 NDRG2	1.15e-04	196	57	4	e6adcfe1a00d4910e0b92848f8a80224e0d6db12
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPRZ1 WNT7B LAPTM4B CYP4F12	1.15e-04	196	57	4	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a6.Fezf2-3110035E14Rik_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	HPX PAPLN TKTL1	1.17e-04	74	57	3	83b762542508f9d6407e4b0087d70bea81a8fc7d
ToppCell	distal-1-Hematologic-Interstitial_Macrophage\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SAMHD1 CHIT1 MMP9 LYZ	1.17e-04	197	57	4	9e5df74aeeefa4d928ec07c036aacb549c797f30
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	DYNC2H1 CTHRC1 LAMC1 MMP9	1.17e-04	197	57	4	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Serous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL28A1 CRISP3 LYZ NDRG2	1.17e-04	197	57	4	d3539607d5477f5dfd85f1fa99b74677c0fa8937
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SAMHD1 CHIT1 MMP9 LYZ	1.17e-04	197	57	4	2efb5acd56b96e5afd8d72b927f1d53cc443766f
Drug	ICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A	IGF1R NMT2 SMYD5 MED13L NIPBL SOAT1	4.66e-06	183	54	6	6925_DN
Drug	Zonisamide	SCN11A CACNA1I CACNA1H	8.38e-06	17	54	3	DB00909
Drug	SureCN2398996	CACNA1I CACNA1H	1.65e-05	3	54	2	CID010220069
Drug	N-desmethylmethsuximide	CACNA1I CACNA1H	1.65e-05	3	54	2	CID000092154
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1I CACNA1H	1.65e-05	3	54	2	CID010679219
Drug	tyrphostin 47	IGF1R CACNA1H	1.65e-05	3	54	2	ctd:C060152
Drug	Cbz-gplgp	MMP9 LYZ SOAT1	1.88e-05	22	54	3	CID000193354
Drug	methsuximide	CACNA1I CACNA1H	3.30e-05	4	54	2	CID000006476
Drug	GlcNAc)7	CHIT1 LYZ	3.30e-05	4	54	2	CID000174167
Drug	AC1O7G5C	CACNA1I CACNA1H	5.50e-05	5	54	2	CID006603942
Drug	phensuximide	CACNA1I CACNA1H	5.50e-05	5	54	2	CID000006839
Drug	Flunarizine	CACNA1I CACNA1H	5.50e-05	5	54	2	DB04841
Drug	poly(dimethylsiloxane	PACS2 CHIT1 LYZ	5.96e-05	32	54	3	CID000024771
Drug	AC1MQ5W8	CACNA1I CACNA1H	8.23e-05	6	54	2	CID003396482
Drug	cerebrocrast	CACNA1I CACNA1H	8.23e-05	6	54	2	CID000159556
Drug	1-pentadecene	CHIT1 LYZ	8.23e-05	6	54	2	CID000025913
Drug	3,4-dihydroquinazoline	CACNA1I CACNA1H	8.23e-05	6	54	2	CID000583065
Drug	tetra-N-acetylchitotetraose	CHIT1 LYZ	8.23e-05	6	54	2	CID003081988
Drug	NACOS-6	CHIT1 LYZ	8.23e-05	6	54	2	CID000197182
Drug	6-mercaptopurine monohydrate; Up 200; 100uM; MCF7; HG-U133A	NMT2 CACNA1I NDRG2 NIPBL ATP4A	9.61e-05	194	54	5	334_UP
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 10uM; MCF7; HG-U133A	IGF1R SMYD5 MED13L NIPBL BTBD3	1.01e-04	196	54	5	2_DN
Drug	benserazide hydrochloride; Down 200; 10uM; SKMEL5; HG-U133A	IGF1R KLHL21 CACNA1I FRYL NIPBL	1.01e-04	196	54	5	631_DN
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; HL60; HT_HG-U133A	KLHL21 NMT2 MMP9 IL4R CEP97	1.01e-04	196	54	5	2551_DN
Drug	Terconazole [67915-31-5]; Up 200; 7.6uM; MCF7; HT_HG-U133A	IGF1R CACNA1I CACNA1H CYP4F12 GPR162	1.01e-04	196	54	5	4407_UP
Drug	Drofenine hydrochloride [548-66-3]; Down 200; 11.4uM; HL60; HT_HG-U133A	DYNC2H1 NMT2 NDRG2 IL4R CEP97	1.06e-04	198	54	5	2714_DN
Drug	LY215840	CACNA1I CACNA1H	1.15e-04	7	54	2	CID000132049
Drug	losigamone	CACNA1I CACNA1H	1.15e-04	7	54	2	CID000060572
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	2.04e-05	4	55	2	EFO_0020830
Disease	osteoarthritis (is_marker_for)	IGF1R MMP9 IL4R	3.84e-05	35	55	3	DOID:8398 (is_marker_for)
Disease	Aortic Diseases	LAMC1 MMP9	5.09e-05	6	55	2	C0003493
Disease	Marfan Syndrome, Type I	LAMC1 MMP9	1.22e-04	9	55	2	C4721845
Disease	interstitial lung disease (is_implicated_in)	MMP9 IL4R	1.52e-04	10	55	2	DOID:3082 (is_implicated_in)
Disease	decadienedioic acid (C10:2-DC) measurement	PAPLN ZFYVE1	1.52e-04	10	55	2	EFO_0800598
Disease	Marfan Syndrome	LAMC1 MMP9	1.86e-04	11	55	2	C0024796
Disease	pancreatic ductal carcinoma (is_marker_for)	IGF1R MMP9 IL4R	2.04e-04	61	55	3	DOID:3587 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	PANX2 MMP9 IL4R	2.36e-04	64	55	3	DOID:4947 (is_marker_for)
Disease	amyotrophic lateral sclerosis (biomarker_via_orthology)	IGF1R PTPRZ1	2.63e-04	13	55	2	DOID:332 (biomarker_via_orthology)
Disease	hypertrophic cardiomyopathy (is_marker_for)	IGF1R MMP9	4.56e-04	17	55	2	DOID:11984 (is_marker_for)
Disease	cystathionine measurement	TEC TEC	5.72e-04	19	55	2	EFO_0010474
Disease	brain age measurement	EEF1AKMT4-ECE2 EEF1AKMT4	6.34e-04	20	55	2	EFO_0010602
Disease	sciatic neuropathy (biomarker_via_orthology)	CACNA1I CACNA1H MMP9	8.47e-04	99	55	3	DOID:11446 (biomarker_via_orthology)
Disease	hypertension (biomarker_via_orthology)	IGF1R CYP4F12 MMP9 CYP4F11	8.55e-04	227	55	4	DOID:10763 (biomarker_via_orthology)
Disease	stroke outcome severity measurement	COL28A1 BTBD3 ZNF292	1.27e-03	114	55	3	EFO_0009603
Disease	perivascular space measurement	WNT7A LAMC1	1.44e-03	30	55	2	EFO_0803382
Disease	migraine disorder, glucose measurement	IGF1R CACNA1H	1.53e-03	31	55	2	EFO_0004468, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
NACCQRWYFTFNGAE	CTHRC1	151	Q96CG8
RCFGYQSKSQYRIWQ	ATP13A4	1141	Q4VNC1
HRFQSCAYRSNQWRY	BTBD3	376	Q9Y2F9
CYFTNWAQYRQGEAR	CHIT1	26	Q13231
AYFCQDRFYWRVSSR	MMP9	671	P14780
YWTECFNALEQGRQY	MED13L	1271	Q71F56
DYGIFQINSRYWCND	LYZ	71	P61626
IGDGNLQYYLYNWRC	NMT2	471	O60551
WHNNGERYYARGCQF	GPR162	156	Q16538
NYGWRAREGFECYDR	HHIPL1	436	Q96JK4
NGYWAFECLTVRDYN	HMGXB3	866	Q12766
TINNEYNYRCWTTNR	IGF1R	196	P08069
YSRDCSNWINVVCRY	FRYL	2156	O94915
QNFKFVWACFNRYYG	NIPBL	2101	Q6KC79
CVWNCYRYINGRNSS	LAPTM4B	266	Q86VI4
NQFQLGTCRLGWAYY	LHFPL1	156	Q86WI0
VCRLDWANGYYRQQR	PTPRZ1	16	P23471
VDYRYNNFFQDLAWR	PACS2	601	Q86VP3
NVYFPWVSQYRFCQL	EXOC6	166	Q8TAG9
CFEDAALWRTYYNNS	DYNC2H1	3641	Q8NCM8
RNCGYREVEYWDQRY	EEF1AKMT4-ECE2	16	P0DPD8
SYRARVRAWAQCYNT	IL4R	196	P24394
CYNPQTGQWRYLAEF	KLHL21	306	Q9UJP4
VRWYYDKQVNSCARF	COL28A1	1086	Q2UY09
YYVCQYCPAGNWANR	CRISP3	166	P54108
QACWRGFYARNYNPQ	CEP97	566	Q8IW35
NASGLCVNWNRYYNV	CACNA1I	311	Q9P0X4
CVNWNRYYNVCRTGS	CACNA1I	316	Q9P0X4
AWTYTFYDNCRRLQC	CYP4F11	36	Q9HBI6
AWTYAFYNNCRRLQC	CYP4F12	36	Q9HCS2
RCDQCEENYFYNRSW	LAMC1	1011	P11047
EENYFYNRSWPGCQE	LAMC1	1016	P11047
GAARNACINWNQYYN	CACNA1H	331	O95180
ACINWNQYYNVCRSG	CACNA1H	336	O95180
EWTFGQRLYQQYTCY	ATP4A	916	P20648
NFTRDQALYARGYCW	PANX2	86	Q96RD6
ALRWLGRYYCFQGNQ	HPX	191	P02790
NGVLLCFYSQEWYAR	SOAT1	511	P35610
SLYAARQYFVQWCAD	SAMHD1	561	Q9Y3Z3
NLDQYEWYCRNMNRS	TEC	241	P42680
ELYWNSYNNRRDLNF	NDRG2	231	Q9UN36
CYPAQVYGQDRRFWR	RECQL4	1171	O94761
NAAYNNRFSYANVAW	OLFM4	366	Q6UX06
RNCGYREVEYWDQRY	EEF1AKMT4	16	P0DPD7
DMYRQFQDWCLRTYG	NOL4	6	O94818
QGTRIAAYWSQQYRC	TNRC18	2226	O15417
NECQYQFRFGRWNCS	WNT7B	71	P56706
YFVASVGQCNRFWYG	PAPLN	771	O95428
SARFRNWQAYMQYCV	ZNF292	531	O60281
RVFRNPYNYGCLDNW	ZDHHC16	316	Q969W1
CPNCGVVYRSRQYWF	ZFYVE1	511	Q9HBF4
WVNNCIGRRNYRYFF	ZDHHC5	136	Q9C0B5
RGYNTHQYARVWQCN	WNT7A	311	O00755
WVNNCIGRRNYRYFF	ZDHHC8	136	Q9ULC8
RQYYFTNGWNLFDCV	SCN11A	1421	Q9UI33
AADACRYLQTYGEWN	WDR11	1076	Q9BZH6
AAQFLWNALYRYRAC	SMYD5	56	Q6GMV2
NIYQRRCEAFGWNTY	TKTL1	171	P51854
AYCRNNLNNLWYEFD	USP33	676	Q8TEY7