Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin filament binding	SPTBN4 MYH14 SPTB SPTBN1 ACTN4 ACTN2 ACTN3 NEB	7.89e-06	227	89	8	GO:0051015
GeneOntologyMolecularFunction	ankyrin binding	SPTBN4 SPTB SPTBN1	1.42e-04	23	89	3	GO:0030506
GeneOntologyBiologicalProcess	ultradian rhythm	ENOX1 ENOX2	1.84e-05	2	89	2	GO:0007624
GeneOntologyCellularComponent	cortical actin cytoskeleton	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	3.24e-06	93	91	6	GO:0030864
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTB SPTBN1	6.58e-06	9	91	3	GO:0008091
GeneOntologyCellularComponent	cortical cytoskeleton	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	2.13e-05	129	91	6	GO:0030863
GeneOntologyCellularComponent	pseudopodium	ACTN4 ACTN2 ACTN3	6.21e-05	18	91	3	GO:0031143
GeneOntologyCellularComponent	striated muscle thin filament	ACTN2 ACTN3 NEB	2.16e-04	27	91	3	GO:0005865
GeneOntologyCellularComponent	myofilament	ACTN2 ACTN3 NEB	3.61e-04	32	91	3	GO:0036379
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTB SPTBN1	6.61e-04	9	91	2	GO:0014731
GeneOntologyCellularComponent	actin cytoskeleton	SPTBN4 KALRN MYH14 SPTB SPTBN1 ACTN4 ACTN2 ACTN3 NEB	9.07e-04	576	91	9	GO:0015629
GeneOntologyCellularComponent	cell cortex	SPTBN4 SPTB SPTBN1 ACTN4 FRYL ACTN2 ACTN3	1.18e-03	371	91	7	GO:0005938
GeneOntologyCellularComponent	endoplasmic reticulum-plasma membrane contact site	GRAMD1B GRAMD1A	1.42e-03	13	91	2	GO:0140268
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	1.65e-03	14	91	2	GO:0097732
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	1.65e-03	14	91	2	GO:0060091
Domain	Spectrin	SPTBN4 KALRN SPTB SPTBN1 ACTN4 ACTN2 ACTN3	9.32e-12	23	88	7	PF00435
Domain	Spectrin_repeat	SPTBN4 KALRN SPTB SPTBN1 ACTN4 ACTN2 ACTN3	5.80e-11	29	88	7	IPR002017
Domain	Spectrin/alpha-actinin	SPTBN4 KALRN SPTB SPTBN1 ACTN4 ACTN2 ACTN3	1.24e-10	32	88	7	IPR018159
Domain	SPEC	SPTBN4 KALRN SPTB SPTBN1 ACTN4 ACTN2 ACTN3	1.24e-10	32	88	7	SM00150
Domain	Actinin_actin-bd_CS	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	8.71e-10	23	88	6	IPR001589
Domain	ACTININ_2	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	8.71e-10	23	88	6	PS00020
Domain	ACTININ_1	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	8.71e-10	23	88	6	PS00019
Domain	Spectrin_bsu	SPTBN4 SPTB SPTBN1	4.03e-07	4	88	3	IPR016343
Domain	CH	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	6.08e-07	65	88	6	SM00033
Domain	CH	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	9.48e-07	70	88	6	PF00307
Domain	-	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	1.03e-06	71	88	6	1.10.418.10
Domain	CH	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	1.22e-06	73	88	6	PS50021
Domain	CH-domain	SPTBN4 SPTB SPTBN1 ACTN4 ACTN2 ACTN3	1.43e-06	75	88	6	IPR001715
Domain	EF-hand_Ca_insen	ACTN4 ACTN2 ACTN3	2.00e-06	6	88	3	IPR014837
Domain	EFhand_Ca_insen	ACTN4 ACTN2 ACTN3	2.00e-06	6	88	3	PF08726
Domain	VAST	GRAMD1B GRAMD1A	6.56e-05	3	88	2	PS51778
Domain	DUF4782	GRAMD1B GRAMD1A	6.56e-05	3	88	2	IPR031968
Domain	DUF4782	GRAMD1B GRAMD1A	6.56e-05	3	88	2	PF16016
Domain	CRAL_TRIO	KALRN TTPA SEC14L4	1.26e-04	21	88	3	PF00650
Domain	-	KALRN TTPA SEC14L4	1.67e-04	23	88	3	3.40.525.10
Domain	SEC14	KALRN TTPA SEC14L4	2.16e-04	25	88	3	SM00516
Domain	CRAL_TRIO	KALRN TTPA SEC14L4	2.72e-04	27	88	3	PS50191
Domain	CRAL-TRIO_dom	KALRN TTPA SEC14L4	3.04e-04	28	88	3	IPR001251
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN1	7.73e-04	9	88	2	IPR001605
Domain	HAT	CRNKL1 PRPF6	9.64e-04	10	88	2	IPR003107
Domain	HAT	CRNKL1 PRPF6	9.64e-04	10	88	2	SM00386
Domain	GAIN_dom_N	CELSR2 ADGRB3	1.17e-03	11	88	2	IPR032471
Domain	CRAL_TRIO_N	TTPA SEC14L4	1.17e-03	11	88	2	PF03765
Domain	GAIN	CELSR2 ADGRB3	1.17e-03	11	88	2	PF16489
Domain	CRAL-bd_toc_tran	TTPA SEC14L4	1.40e-03	12	88	2	IPR001071
Domain	CRAL_TRIO_N	TTPA SEC14L4	1.40e-03	12	88	2	SM01100
Domain	CRAL/TRIO_N_dom	TTPA SEC14L4	2.21e-03	15	88	2	IPR011074
Domain	LRR_6	TONSL NLRP1 LRRC71	2.22e-03	55	88	3	PF13516
Domain	GRAM	GRAMD1B GRAMD1A	2.52e-03	16	88	2	SM00568
Domain	-	CRNKL1 P3H2 TONSL PRPF6 P3H4	2.97e-03	207	88	5	1.25.40.10
Domain	GRAM	GRAMD1B GRAMD1A	4.77e-03	22	88	2	PF02893
Domain	GRAM	GRAMD1B GRAMD1A	4.77e-03	22	88	2	IPR004182
Domain	TPR-like_helical_dom	CRNKL1 P3H2 TONSL PRPF6 P3H4	4.90e-03	233	88	5	IPR011990
Domain	-	MDN1 ANTXR2 ITIH3	5.15e-03	74	88	3	3.40.50.410
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	SPTBN1 ACTN4 ACTN2 ACTN3	3.63e-06	23	66	4	M913
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTB SPTBN1	1.15e-05	10	66	3	MM15112
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	ACTN4 ACTN2 ACTN3 NEB	2.87e-05	38	66	4	M39549
Pubmed	Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.	ACTN4 ACTN2 ACTN3 NEB	9.51e-09	10	92	4	20368620
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTBN4 KALRN SPTB SPTBN1	1.49e-08	11	92	4	17607528
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTBN4 SPTB SPTBN1	1.79e-08	3	92	3	11294830
Pubmed	The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.	ACTN4 ACTN2 ACTN3	1.79e-08	3	92	3	10656685
Pubmed	Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.	ACTN4 ACTN2 ACTN3	1.79e-08	3	92	3	8104223
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTBN4 SPTB SPTBN1	1.79e-08	3	92	3	32425157
Pubmed	Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.	ACTN4 ACTN2 ACTN3	7.15e-08	4	92	3	1629252
Pubmed	Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.	ACTN4 ACTN2 ACTN3	7.15e-08	4	92	3	16807302
Pubmed	Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.	ACTN4 ACTN2 ACTN3	1.78e-07	5	92	3	15841212
Pubmed	The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.	ACTN4 ACTN2 ACTN3	1.78e-07	5	92	3	12837758
Pubmed	Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.	ACTN4 ACTN2 ACTN3	1.78e-07	5	92	3	19943616
Pubmed	Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.	ACTN4 ACTN2 ACTN3	3.56e-07	6	92	3	18425115
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ACTN4 ACTN2 ACTN3	3.56e-07	6	92	3	22693585
Pubmed	Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.	ACTN2 ACTN3 NEB	9.94e-07	8	92	3	11309420
Pubmed	Mice deficient in alpha-actinin-4 have severe glomerular disease.	ACTN4 ACTN2 ACTN3	9.94e-07	8	92	3	12782671
Pubmed	CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.	ACTN4 ACTN2 ACTN3	9.94e-07	8	92	3	20215401
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PCNX2 SPTBN4 TPRA1 GPR137C VEZT MYH14 SPTB TMC6 PRKAR1B IGSF9 FRYL POMT1 ADCY1 PLEKHM1 ZNF440 FRMD3	1.71e-06	1489	92	16	28611215
Pubmed	Molecular diversity of myofibrillar proteins: gene regulation and functional significance.	ACTN2 ACTN3 NEB	3.87e-06	12	92	3	8618961
Pubmed	Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.	ACTN4 ACTN2 ACTN3	3.87e-06	12	92	3	15465019
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 SPTB SPTBN1	5.03e-06	13	92	3	18796539
Pubmed	Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo.	ACTN2 ACTN3	6.92e-06	2	92	2	9675099
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	6.92e-06	2	92	2	11687802
Pubmed	Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.	ACTN2 ACTN3	6.92e-06	2	92	2	19150855
Pubmed	α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.	ACTN2 ACTN3	6.92e-06	2	92	2	22253474
Pubmed	alpha-actinin-3 and performance.	ACTN2 ACTN3	6.92e-06	2	92	2	19696509
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	6.92e-06	2	92	2	34910522
Pubmed	Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes.	ACTN2 ACTN3	6.92e-06	2	92	2	32451822
Pubmed	Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.	ACTN2 ACTN3	6.92e-06	2	92	2	1339456
Pubmed	Each actin subunit has three nebulin binding sites: implications for steric blocking.	ACTN4 NEB	6.92e-06	2	92	2	11882289
Pubmed	Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane.	GRAMD1B GRAMD1A	6.92e-06	2	92	2	32719109
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KALRN MYH14 SPTB SPTBN1 CDK5RAP2 ACTN4 ACTN2 ACTN3 NEB	7.03e-06	497	92	9	23414517
Pubmed	Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.	ACTN4 ACTN2 ACTN3	7.96e-06	15	92	3	11440986
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTB SPTBN1	1.42e-05	18	92	3	12119179
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	RNF31 KALRN CKAP5 ACTN4 ACTN2	1.60e-05	118	92	5	21078624
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.07e-05	3	92	2	30801007
Pubmed	α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.	ACTN4 ACTN3	2.07e-05	3	92	2	21784188
Pubmed	Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment.	ACTN4 ACTN2	2.07e-05	3	92	2	21940706
Pubmed	alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice.	TTPA SEC14L4	2.07e-05	3	92	2	19923370
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	2.07e-05	3	92	2	8479293
Pubmed	Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity.	SPTBN4 SPTB	2.07e-05	3	92	2	32052742
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	2.07e-05	3	92	2	1467942
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTBN4 SPTB SPTBN1	3.95e-05	25	92	3	8493579
Pubmed	Clinical evaluation and therapeutic monitoring value of serum tumor markers in lung cancer.	MUC16 GRP	4.14e-05	4	92	2	26560853
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	4.14e-05	4	92	2	18849963
Pubmed	Phosphorylation of eukaryotic translation initiation factor 4E and eukaryotic translation initiation factor 4E-binding protein (4EBP) and their upstream signaling components undergo diurnal oscillation in the mouse hippocampus: implications for memory persistence.	EIF4E ADCY1	4.14e-05	4	92	2	24895127
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTB SPTBN1	4.14e-05	4	92	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTB SPTBN1	4.14e-05	4	92	2	3862089
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTB SPTBN1	4.14e-05	4	92	2	21412925
Pubmed	Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors.	ACTN4 ACTN2	4.14e-05	4	92	2	16510730
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTB SPTBN1	4.14e-05	4	92	2	12820899
Pubmed	Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.	ACTN2 NEB	4.14e-05	4	92	2	9501083
Pubmed	Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo.	ACTN2 NEB	4.14e-05	4	92	2	16902413
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	ACTN4 ACTN2 ACTN3	5.00e-05	27	92	3	36899856
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CRNKL1 MDN1 MYH14 SPTBN1 CKAP5 ACTN4 FRYL PRPF6 SYMPK	5.97e-05	653	92	9	22586326
Pubmed	Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.	ACTN2 ACTN3	6.89e-05	5	92	2	9268580
Pubmed	Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.	ACTN2 ACTN3	6.89e-05	5	92	2	21536590
Pubmed	p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.	ACTN2 ACTN3	6.89e-05	5	92	2	9438383
Pubmed	Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.	ACTN2 ACTN3	6.89e-05	5	92	2	11171996
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	6.89e-05	5	92	2	24920589
Pubmed	Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.	GRAMD1B GRAMD1A	1.03e-04	6	92	2	30220461
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPTBN4 GABRG1 PRDM8 MDN1 ANTXR2 ACACB MYH14 SPTBN1 ACTN4 PRPF6 ACTN2 ACTN3 NEB	1.07e-04	1442	92	13	35575683
Pubmed	Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).	CRNKL1 ACTN4 P3H4	1.30e-04	37	92	3	16396496
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	MYH14 SPTBN1 EIF4E CKAP5 NLRP1 ACTN4	1.37e-04	295	92	6	26209609
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	SPTBN1 STRC STRCP1	1.41e-04	38	92	3	38346162
Pubmed	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	ACTN4 ACTN2	1.44e-04	7	92	2	11724819
Pubmed	KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.	ACTN2 NEB	1.44e-04	7	92	2	28826497
Pubmed	The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development.	SPTB ACTN2	1.44e-04	7	92	2	29565969
Pubmed	The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.	ACTN2 ACTN3	1.92e-04	8	92	2	11381084
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	1.92e-04	8	92	2	21165971
Pubmed	The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.	ACTN2 ACTN3	1.92e-04	8	92	2	18687124
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GRAMD1B CELSR2 ACACB KALRN VEZT SPTBN1 GRAMD1A CKAP5 ADGRB3 PRKAR1B ACTN4	2.11e-04	1139	92	11	36417873
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	SPTBN1 CKAP5 CDK5RAP2	2.19e-04	44	92	3	20200978
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	MYH14 ACTN4 ACTN3	2.35e-04	45	92	3	22114352
Pubmed	Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.	ACTN2 ACTN3	2.46e-04	9	92	2	11114196
Pubmed	Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease.	SPTB CDK5RAP2	2.46e-04	9	92	2	658175
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	MDN1 GYS1 SPTBN1 CKAP5 PRPF6 SYMPK	2.59e-04	332	92	6	32786267
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTB SPTBN1	3.07e-04	10	92	2	22159418
Pubmed	The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration.	LMX1A SPTBN1	3.07e-04	10	92	2	34732824
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CRNKL1 MDN1 ACACB SPTBN1 PRPF6 NEB SMC5	3.59e-04	497	92	7	36774506
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	3.75e-04	11	92	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	3.75e-04	11	92	2	31776257
Pubmed	Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.	ACTN2 ACTN3	3.75e-04	11	92	2	16585392
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SPTBN4 KDM3A CRNKL1 RNF123 KALRN MYH14 SPTB SPTBN1 CKAP5 ADGRB3 ACTN4	5.84e-04	1285	92	11	35914814
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	ZNF419 PRDM8 MDN1 GYS1 SPTBN1 SLC49A4 CKAP5 ACTN4 PRPF6 POMT1 NEB	6.14e-04	1293	92	11	15342556
Pubmed	New sequence variants associated with bone mineral density.	SPTBN1 CKAP5	6.17e-04	14	92	2	19079262
Pubmed	Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma.	ACTN4 PRPF6	6.17e-04	14	92	2	30542119
Pubmed	Filamin C is Essential for mammalian myocardial integrity.	ACTN4 ACTN2	6.17e-04	14	92	2	36706168
Pubmed	The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.	GYS1 SPTBN1 ACTN4	6.95e-04	65	92	3	32521226
Pubmed	PRAK, a novel protein kinase regulated by the p38 MAP kinase.	GYS1 EIF4E	7.11e-04	15	92	2	9628874
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	PRKAR1B ADCY1	7.11e-04	15	92	2	2165385
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	GYS1 SPTBN1 CKAP5 FRYL	8.01e-04	156	92	4	22952844
Pubmed	Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.	SPDYA SMC5	8.11e-04	16	92	2	20339383
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	VEZT ADCY1	8.11e-04	16	92	2	17567809
Pubmed	Periaxin is required for hexagonal geometry and membrane organization of mature lens fibers.	SPTBN4 SPTBN1	8.11e-04	16	92	2	21745462
Pubmed	Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.	ACTN2 NEB	8.11e-04	16	92	2	25987543
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	9.17e-04	17	92	2	20856818
Pubmed	Genome-wide association of lipid-lowering response to statins in combined study populations.	CELSR2 ADGRB3 CDK5RAP2	9.36e-04	72	92	3	20339536
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SPTBN4 MDN1 CELSR2 KALRN SPTBN1 CKAP5 ADGRB3 PRKAR1B CDK5RAP2	1.03e-03	963	92	9	28671696
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	TPRA1 GPR137C ADGRB3	1.22e-03	79	92	3	12679517
Pubmed	Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.	PRDM8 GRP	1.27e-03	20	92	2	20346763
Interaction	LRRC7 interactions	RNF123 SPTBN1 PRKAR1B ACTN4 ACTN2	5.11e-06	58	87	5	int:LRRC7
Cytoband	19q13.13	SPTBN4 GRAMD1A	4.10e-04	15	92	2	19q13.13
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF419 SPTBN4 MYH14 GYS1 GRAMD1A GARIN5A ACTN4 ZNF772 SYMPK	6.58e-04	1192	92	9	chr19q13
Cytoband	3q21.2	TPRA1 KALRN	8.14e-04	21	92	2	3q21.2
Cytoband	15q15.3	STRC STRCP1	1.16e-03	25	92	2	15q15.3
Cytoband	19p13.2	MUC16 ZNF699 ZNF763 ZNF440	1.20e-03	229	92	4	19p13.2
GeneFamily	Actinins	ACTN4 ACTN2 ACTN3	1.53e-07	4	62	3	1112
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTB SPTBN1	1.33e-06	7	62	3	1113
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	GRAMD1B GRAMD1A	8.81e-04	13	62	2	1146
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 SPTBN4 CELSR2 KALRN PRKAR1B ADCY1	3.03e-06	193	92	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 SPTBN4 CELSR2 KALRN PRKAR1B ADCY1	3.03e-06	193	92	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 SPTBN4 CELSR2 KALRN PRKAR1B ADCY1	3.03e-06	193	92	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	Control-B_naive-9\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	GRAMD1B GYS1 PRKAR1B SPDYA P3H4	5.72e-06	123	92	5	36d509eae874733f1a4f8189ad3000136ff6425e
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E16.5-samps / Age Group, Lineage, Cell class and subclass	AMHR2 CDK5RAP2 LIPT2 SVOPL ITIH3	7.22e-06	129	92	5	5e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IL12RB2 SPTB GARIN5A ACTN3 NEB	1.23e-05	144	92	5	f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|Heart / Disease (COVID-19 only), tissue and cell type	IL12RB2 SPTB GARIN5A ACTN3 NEB	1.76e-05	155	92	5	d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRG1 NSUN3 P3H2 SPTB ACTN3	1.87e-05	157	92	5	370f44047ef438b8f1124c2c2761c150c0d8c57f
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KDM3A CELSR2 IGSF9 N4BP3 PROC	2.30e-05	164	92	5	1aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|367C / Donor, Lineage, Cell class and subclass (all cells)	KDM3A CELSR2 IGSF9 N4BP3 PROC	2.44e-05	166	92	5	430d604f5bef9fae20dc81492e6695616f6701a3
ToppCell	10x5'-Lung-Myeloid_Dendritic-DC1\|Lung / Manually curated celltypes from each tissue	ENOX1 CFAP52 P3H2 UTF1 PROC	2.90e-05	172	92	5	243b8bb01cbec5c1bf8802cbf8a6153356b4c384
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_2\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CFAP52 LMX1A GRP FRMD3 LRRC71	3.23e-05	176	92	5	8e0ac3ad5e47614b4befabd674a40e3eaae553f3
ToppCell	Adult-Immune-enucleated_erythrocyte-D231\|Adult / Lineage, Cell type, age group and donor	SPTB MUC16 ACTN2 ZNF763 SVOPL	3.32e-05	177	92	5	15ee303fb6caea1fd645c3b777666196ce500a1c
ToppCell	ASK440-Immune-Mast_cell\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	AMHR2 ANTXR2 SPTB SVOPL INKA1	3.41e-05	178	92	5	dcefc4afca3a40d1bd44722e66bca6b45a6c6c55
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH14 GJC3 ADCY1 SEC14L4 FRMD3	3.79e-05	182	92	5	a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM8 P3H2 TONSL GJC3 FRMD3	3.89e-05	183	92	5	876b4f128c2168fdae7488201ff44f19c06c8415
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM8 P3H2 TONSL GJC3 FRMD3	3.89e-05	183	92	5	b190b650e61b1b20baf5e42d04acac82d3fd1400
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRDM8 P3H2 TONSL GJC3 FRMD3	3.89e-05	183	92	5	8330c39184ce076e1f95fd3725b68af551d89db0
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	GRAMD1B ENOX1 SPTB SLC49A4 ACTN2	4.65e-05	190	92	5	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK-early_MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AMHR2 KALRN SLC35D3 SVOPL INKA1	4.77e-05	191	92	5	3839bf57419d3ec3d4464277bb33301d2b7d701f
ToppCell	HSPCs-Mk_prog.\|HSPCs / Lineage and Cell class	KALRN P3H2 SLC35D3 PRODH INKA1	5.14e-05	194	92	5	5c05d508f5c29e6efe87506bf59e3b0fe5922f65
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-early_MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	AMHR2 KALRN SLC35D3 SVOPL INKA1	5.26e-05	195	92	5	9b4f217325afb2efb9c65f298ac87649cb1e1af9
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN4 SPTB SPTBN1	9.88e-08	4	87	3	DOID:0050882 (implicated_via_orthology)
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN2 ACTN3	2.47e-07	5	87	3	DOID:0111128 (implicated_via_orthology)
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	8.59e-06	2	87	2	DOID:0110471 (implicated_via_orthology)
Disease	histidine measurement, amino acid measurement	PRKAR1B PRODH	2.57e-05	3	87	2	EFO_0005134, EFO_0009769
Disease	Nonsyndromic genetic hearing loss	LMX1A MYH14 STRC ADCY1	7.69e-05	76	87	4	cv:C5680182
Disease	cancer antigen 125 measurement	GAL3ST3 MUC16	3.81e-04	10	87	2	EFO_0010603
Disease	interleukin-6 measurement, response to stimulus	ABHD16B MUC16	4.65e-04	11	87	2	EFO_0004810, GO_0050896
Disease	Hereditary hearing loss and deafness	LMX1A MYH14 STRC ADCY1	9.31e-04	146	87	4	cv:C0236038
Disease	preeclampsia, hypertension, pregnancy-induced	PRDM8 ACTN4	1.00e-03	16	87	2	EFO_0000668, MONDO_0024664
Disease	IGF-1 measurement, IGFBP-3 measurement	CELSR2 ADCY1	1.14e-03	17	87	2	EFO_0004626, EFO_0004627
Disease	bipolar disorder, schizophrenia, response to lithium ion	GRAMD1B ADCY1	1.58e-03	20	87	2	GO_0010226, MONDO_0004985, MONDO_0005090
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	IL12RB2 TPRA1 ANTXR2 ABHD16B	1.63e-03	170	87	4	EFO_0000685, EFO_0007791, EFO_0007837

Protein segments in the cluster

Peptide	Gene	Start	Entry
YERLASELLEWIRRT	ACTN2	286	P35609
RLDPYLRSLELLEKW	ANAPC2	121	Q9UJX6
RRRALEDWLLSVFLA	BLACE	36	A4D250
ALWRYIRSERSIILI	ADGRB3	901	O60242
GYEEWLLNEIRRLER	ACTN4	396	O43707
RLDALWALLRRQYDR	ANTXR2	451	P58335
WALLEALHLYRALTE	CELSR2	2456	Q9HCU4
REILLQGRLYLSENW	GRAMD1A	116	Q96CP6
RDILLQGRLYLSENW	GRAMD1B	121	Q3KR37
RYRVDEDWCLALLRS	ABHD16B	386	Q9H3Z7
RRADIYSLALLLWEI	AMHR2	406	Q16671
EEAYRRLKLLWRVSL	CDK5RAP2	1791	Q96SN8
LRALSWRRLYLSRAK	ORAI3	46	Q9BRQ5
LYWRLRRLLLEDQVK	ACACB	2326	O00763
GLDRERLYWELSNLT	MUC16	12156	Q8WXI7
LRLLWAYVAQLGARL	GJC3	131	Q8NFK1
ARLDSFLSQLRWELL	INKA1	6	Q96EL1
NEYDSLRLRWLRQTL	NSUN3	161	Q9H649
TLRDLFRWAERYRLA	MDN1	1271	Q9NU22
LRWQLDAYRNEVELL	ENOX2	421	Q16206
KLWNRLYRLRDSDEI	FANCM	686	Q8IYD8
LQLWRLLLYRERRLS	GPR137C	66	Q8N3F9
QRRSDLDRFWLETLL	EIF4E	121	P06730
WRDEGLVLLNRLRYR	IL12RB2	246	Q99665
ARWLEVLRTYLELVL	FBXO33	176	Q7Z6M2
WDYKNRELLARLSLH	CFAP52	96	Q8N1V2
ATYERLFRWLVLRLN	MYH14	446	Q7Z406
KVWYDRLTLLALLDR	PCNX2	821	A6NKB5
VILDRFLLRLNDSFW	LMX1A	41	Q8TE12
YILILWAVLELSSRR	OR51D1	231	Q8NGF3
RRWREISASLLYQAL	NLRP1	146	Q9C000
LPSLLRTLFDWYRRQ	FRYL	71	O94915
LREYIRWEEAARNLL	GRP	71	P07492
LWYLRLLRLLDRGSF	KALRN	11	O60229
YIADGLRLNRSLLWL	LRRC71	271	Q8N4P6
QWVRLLYRLRFLSAS	GARIN5A	226	Q6IPT2
ALWFTLDPLYRELER	P3H2	666	Q8IVL5
SLWLELRKYLDREET	PCDHA1	191	Q9Y5I3
LTRLCRWDKRLLSVY	PANX3	291	Q96QZ0
LLVRLGEYDLRRWEK	PROC	261	P04070
ALLSLWYLLRRRRNV	POMT1	611	Q9Y6A1
RLARNLLQDVLRSWY	FCSK	936	Q8N0W3
LLQDVLRSWYARLPA	FCSK	941	Q8N0W3
LRRLLAWDLDDVLYA	GAL3ST3	251	Q96A11
LKEARRALSWSYDIL	FRMD3	501	A2A2Y4
DIRLRLDYLWAAQAE	ADCY1	806	Q08828
LIAVEIYRWIRDALR	CKAP5	186	Q14008
ERALDVDYRNITLWL	CRNKL1	266	Q9BZJ0
RWIEVYSLLRRAFLV	KDM3A	76	Q9Y4C1
RLLRIWNDGRVLYTL	GABRG1	166	Q8N1C3
RVYGRRWLVLLLFSL	SLC49A4	46	Q96SL1
LKLWGIDRDSYRRIL	PRKAR1B	221	P31321
RNRTERLSDLLDWKY	GYS1	586	P13807
PNADDYFLLRWLRAR	SEC14L4	31	Q9UDX3
LRWQLDAYRNEVELL	ENOX1	436	Q8TC92
YAELLGLQDRWLRRL	LIPT2	16	A6NK58
ALWRDLVRKVLASYL	PLEKHM1	766	Q9Y4G2
SRRSLKDAYLEVWRL	SLC35D3	381	Q5M8T2
LKLRDQLWDRIDYRA	SPDYA	161	Q5MJ70
ELLECLSWRRGALLY	RIMOC1	126	A6NDU8
LWLALARLETYENAR	PRPF6	436	O94906
RLWAYLTIEQLLEKR	ITIH3	556	Q06033
SLRRIAKDEELLVWY	PRDM8	116	Q9NQV8
AYRSRRTWELARSLL	PRODH	61	O43272
RRTLDWIYSVLLLAI	SMIM27	6	A0A1B0GUW7
DSLALLANRRRYWEL	STRC	1146	Q7RTU9
LLADRYGRWKILLIS	SVOPL	106	Q8N434
VIRLWEYLLELLRAR	SPTBN1	506	Q01082
LLRAESLAYADILLW	B3GNT9	181	Q6UX72
GYEDWLLSEIRRLQR	ACTN3	391	Q08043
LFYLRDWTALRLQKL	RNF31	931	Q96EP0
EDIGTSRVRYWDLLL	TPRA1	36	Q86W33
EEWALLDISQRKLYR	ZNF440	16	Q8IYI8
LDIYWLLRVCLRTIE	RNF123	836	Q5XPI4
WVKLYRRDLDLETRQ	TONSL	641	Q96HA7
SWRESARYLEAALRL	P3H4	51	Q92791
DLDGLLDWLRDAYRL	SPTBN4	781	Q9H254
ARKDNILRLWSYLQE	SPTB	501	P11277
LRARDFDLDLAWRLL	TTPA	56	P49638
YTALADWTLRERLLP	IGSF9	996	Q9P2J2
DVRARLDLAFAWLYQ	SYMPK	611	Q92797
LDSLALLANRRRYWE	STRCP1	1146	A6NGW2
VRSAWPSLRLYDLEL	TMC6	121	Q7Z403
LYLATVADDRLLRIW	WSB2	306	Q9NYS7
LFVYLVIRALRLWRT	VEZT	176	Q9HBM0
EEWALLDLAQRNLYR	ZNF699	31	Q32M78
EEWALLDISQRKLYR	ZNF763	16	Q0D2J5
LRQRFRDTYDAVLWL	SMC5	456	Q8IY18
WRLLDDAQRLLYRNV	ZNF419	41	Q96HQ0
WVLLDEAQRLLYRDV	ZNF772	41	Q68DY9
WRALLLDRRQALPTY	UTF1	81	Q5T230
RLWLAELKRLYVERL	N4BP3	291	O15049
LIRAKRAYWNASDLR	NEB	5251	P20929