Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN10A SCN1A SCN2A SCN3A SCN9A

1.30e-1026255GO:0005248
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN9A

1.90e-0914254GO:0031402
GeneOntologyMolecularFunctionsodium channel activity

SCN10A SCN1A SCN2A SCN3A SCN9A

5.02e-0952255GO:0005272
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN9A

2.80e-0826254GO:0031420
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

3.65e-08627259GO:0022890
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN10A SCN1A SCN2A SCN3A SCN9A SLC5A4

5.59e-08171256GO:0015081
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

5.97e-08664259GO:0008324
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN10A CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

6.22e-08465258GO:0046873
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

1.85e-07758259GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

2.71e-07793259GO:0015075
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN10A SCN1A SCN2A

1.17e-0617253GO:0099508
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

3.31e-06343256GO:0005261
GeneOntologyMolecularFunctiontransmembrane transporter activity

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

7.35e-061180259GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

1.50e-051289259GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

1.74e-05459256GO:0005216
GeneOntologyMolecularFunctionchannel activity

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

3.71e-05525256GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

3.75e-05526256GO:0022803
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

SCN10A CACNA1A SCN1A SCN2A

7.27e-05182254GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

SCN10A CACNA1A SCN1A SCN2A

7.59e-05184254GO:0022832
GeneOntologyMolecularFunctiongated channel activity

SCN10A CACNA1A SCN1A SCN2A

7.37e-04334254GO:0022836
GeneOntologyMolecularFunctioncalmodulin binding

CACNA1A SCN2A SCN3A

2.88e-03230253GO:0005516
GeneOntologyMolecularFunctionamide binding

CACNA1A PSAP SCARB1

5.99e-03299253GO:0033218
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

CYC1 ATP7A SLC5A4

6.10e-03301253GO:0022853
GeneOntologyMolecularFunctionamyloid-beta binding

CACNA1A SCARB1

7.18e-03102252GO:0001540
GeneOntologyMolecularFunctionG protein-coupled receptor binding

PSAP PTH NTS

8.32e-03337253GO:0001664
GeneOntologyMolecularFunctionhormone activity

PTH NTS

1.23e-02135252GO:0005179
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN10A SCN1A SCN2A SCN3A SCN9A

9.52e-1036275GO:0086010
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

6.04e-09112276GO:0019226
GeneOntologyBiologicalProcessmembrane depolarization

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

9.63e-09121276GO:0051899
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

1.60e-0862275GO:0086002
GeneOntologyBiologicalProcessneuronal action potential

SCN10A SCN1A SCN2A SCN3A SCN9A

1.73e-0863275GO:0019228
GeneOntologyBiologicalProcessbehavioral response to pain

SCN10A CACNA1A SCN3A SCN9A

8.16e-0832274GO:0048266
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN10A SCN1A SCN2A SCN3A SCN9A

8.92e-0887275GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

1.25e-0793275GO:0086003
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN10A SCN1A SCN2A SCN3A SCN9A SLC5A4

2.43e-07208276GO:0035725
GeneOntologyBiologicalProcessresponse to pain

SCN10A CACNA1A SCN3A SCN9A

5.58e-0751274GO:0048265
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

5.92e-07127275GO:0070252
GeneOntologyBiologicalProcessbehavior

SCN10A CACNA1A ATP7A PSAP SCN1A SCN2A SCN3A NTS SCN9A

1.17e-06891279GO:0007610
GeneOntologyBiologicalProcesssodium ion transport

SCN10A SCN1A SCN2A SCN3A SCN9A SLC5A4

1.24e-06275276GO:0006814
GeneOntologyBiologicalProcessactin filament-based movement

SCN10A SCN1A SCN2A SCN3A SCN9A

1.49e-06153275GO:0030048
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

1.55e-06922279GO:0098662
GeneOntologyBiologicalProcesscerebellar Purkinje cell differentiation

CACNA1A ATP7A PSAP

1.61e-0618273GO:0021702
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

1.85e-06942279GO:0098655
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer formation

CACNA1A ATP7A PSAP

2.25e-0620273GO:0021694
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

2.29e-06167275GO:0060048
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

3.48e-061017279GO:0098660
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer morphogenesis

CACNA1A ATP7A PSAP

4.51e-0625273GO:0021692
GeneOntologyBiologicalProcessaction potential

SCN10A SCN1A SCN2A SCN3A SCN9A

5.67e-06201275GO:0001508
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

7.38e-061115279GO:0034220
GeneOntologyBiologicalProcessstriated muscle contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

8.23e-06217275GO:0006941
GeneOntologyBiologicalProcesscell differentiation in hindbrain

CACNA1A ATP7A PSAP

9.67e-0632273GO:0021533
GeneOntologyBiologicalProcessmonoatomic cation transport

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

9.96e-061157279GO:0006812
GeneOntologyBiologicalProcesscerebellar cortex formation

CACNA1A ATP7A PSAP

1.17e-0534273GO:0021697
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer development

CACNA1A ATP7A PSAP

1.77e-0539273GO:0021680
GeneOntologyBiologicalProcessmulticellular organismal response to stress

SCN10A CACNA1A SCN3A SCN9A

2.09e-05126274GO:0033555
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

SCN10A SCN1A SCN9A

2.38e-0543273GO:0062149
GeneOntologyBiologicalProcessmetal ion transport

SCN10A CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

2.89e-051000278GO:0030001
GeneOntologyBiologicalProcessdetection of stimulus

SCN10A OR2T12 OR2T33 OR2L13 SCN1A SCARB1 SCN9A

3.01e-05722277GO:0051606
GeneOntologyBiologicalProcesscerebellar cortex morphogenesis

CACNA1A ATP7A PSAP

3.33e-0548273GO:0021696
GeneOntologyBiologicalProcessheart contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

3.79e-05298275GO:0060047
GeneOntologyBiologicalProcessmonoatomic ion transport

SCN10A CYC1 CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A SLC5A4

3.93e-051374279GO:0006811
GeneOntologyBiologicalProcessheart process

SCN10A SCN1A SCN2A SCN3A SCN9A

4.50e-05309275GO:0003015
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

SCN10A SCN1A SCN9A

5.58e-0557273GO:0050974
GeneOntologyBiologicalProcesscerebellum morphogenesis

CACNA1A ATP7A PSAP

6.51e-0560273GO:0021587
GeneOntologyBiologicalProcesswalking behavior

CACNA1A PSAP SCN1A

6.51e-0560273GO:0090659
GeneOntologyBiologicalProcessregulation of membrane potential

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

7.03e-05559276GO:0042391
GeneOntologyBiologicalProcesshindbrain morphogenesis

CACNA1A ATP7A PSAP

7.90e-0564273GO:0021575
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

SCN10A OR2T12 OR2T33 OR2L13 SCN1A SCN9A

8.78e-05582276GO:0050906
GeneOntologyBiologicalProcesscerebellar cortex development

CACNA1A ATP7A PSAP

1.08e-0471273GO:0021695
GeneOntologyBiologicalProcessdetection of mechanical stimulus

SCN10A SCN1A SCN9A

1.27e-0475273GO:0050982
GeneOntologyBiologicalProcessactin filament-based process

SCN10A RHPN2P1 RHPN2 SCN1A SCN2A SCN3A SCN9A

1.32e-04912277GO:0030029
GeneOntologyBiologicalProcessmuscle contraction

SCN10A SCN1A SCN2A SCN3A SCN9A

1.52e-04400275GO:0006936
GeneOntologyBiologicalProcessblood circulation

SCN10A SCN1A SCN2A SCN3A NTS SCN9A

1.58e-04648276GO:0008015
GeneOntologyBiologicalProcesscellular response to antibiotic

ATP7A SCN3A

1.96e-0416272GO:0071236
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

SCN10A PSAP SCN1A SCN9A

2.46e-04238274GO:0050954
GeneOntologyBiologicalProcesscirculatory system process

SCN10A SCN1A SCN2A SCN3A NTS SCN9A

3.08e-04733276GO:0003013
GeneOntologyBiologicalProcesssensory perception of pain

SCN10A SCN1A SCN9A

3.43e-04105273GO:0019233
GeneOntologyBiologicalProcesssensory perception

SCN10A OR2T12 PSAP OR2T33 OR2L13 SCN1A SCN9A

3.56e-041072277GO:0007600
GeneOntologyBiologicalProcesslocomotory behavior

CACNA1A ATP7A PSAP SCN1A

4.81e-04284274GO:0007626
GeneOntologyBiologicalProcessresponse to lead ion

ATP7A PTH

4.86e-0425272GO:0010288
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception of pain

SCN10A SCN9A

5.26e-0426272GO:0050965
GeneOntologyBiologicalProcesspositive regulation of monooxygenase activity

ATP7A SCARB1

5.68e-0427272GO:0032770
GeneOntologyBiologicalProcessmuscle system process

SCN10A SCN1A SCN2A SCN3A SCN9A

6.41e-04547275GO:0003012
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception

SCN10A SCN9A

7.02e-0430272GO:0050961
GeneOntologyBiologicalProcesscerebellum development

CACNA1A ATP7A PSAP

7.78e-04139273GO:0021549
GeneOntologyBiologicalProcessregulation of presynaptic membrane potential

SCN10A SCN1A

7.99e-0432272GO:0099505
GeneOntologyBiologicalProcessdetection of temperature stimulus

SCN10A SCN9A

8.50e-0433272GO:0016048
GeneOntologyBiologicalProcessmetencephalon development

CACNA1A ATP7A PSAP

1.03e-03153273GO:0022037
GeneOntologyBiologicalProcesssensory perception of temperature stimulus

SCN10A SCN9A

1.13e-0338272GO:0050951
GeneOntologyBiologicalProcessnegative regulation of stress fiber assembly

RHPN2P1 RHPN2

1.19e-0339272GO:0051497
GeneOntologyBiologicalProcessproton transmembrane transport

CYC1 ATP7A SLC5A4

1.39e-03170273GO:1902600
GeneOntologyBiologicalProcessdetection of external stimulus

SCN10A SCN1A SCN9A

1.46e-03173273GO:0009581
GeneOntologyBiologicalProcessregulation of monooxygenase activity

ATP7A SCARB1

1.51e-0344272GO:0032768
GeneOntologyBiologicalProcessresponse to antibiotic

ATP7A SCN3A

1.51e-0344272GO:0046677
GeneOntologyBiologicalProcessdetection of abiotic stimulus

SCN10A SCN1A SCN9A

1.51e-03175273GO:0009582
GeneOntologyBiologicalProcessnegative regulation of actin filament bundle assembly

RHPN2P1 RHPN2

1.58e-0345272GO:0032232
GeneOntologyBiologicalProcesspositive regulation of oxidoreductase activity

ATP7A SCARB1

1.65e-0346272GO:0051353
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

DGKE OR2T12 PSAP OR2T33 PTH OR2L13 NTS

1.70e-031395277GO:0007186
GeneOntologyBiologicalProcessadult walking behavior

CACNA1A SCN1A

1.94e-0350272GO:0007628
GeneOntologyBiologicalProcessdetermination of adult lifespan

SCN1A SCN2A

2.26e-0354272GO:0008340
GeneOntologyBiologicalProcesshindbrain development

CACNA1A ATP7A PSAP

2.47e-03208273GO:0030902
GeneOntologyBiologicalProcesscentral nervous system neuron differentiation

CACNA1A ATP7A PSAP

2.79e-03217273GO:0021953
GeneOntologyBiologicalProcessneuromuscular process

CACNA1A PSAP SCN1A

3.09e-03225273GO:0050905
GeneOntologyBiologicalProcessresponse to cadmium ion

ATP7A PTH

3.56e-0368272GO:0046686
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN10A SCN1A SCN2A SCN3A SCN9A

9.79e-1217255GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN10A SCN1A SCN2A SCN3A SCN9A

1.86e-1029255GO:0034706
GeneOntologyCellularComponentcation channel complex

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

2.80e-07235256GO:0034703
GeneOntologyCellularComponenttransmembrane transporter complex

SCN10A CYC1 CACNA1A SCN1A SCN2A SCN3A SCN9A

1.92e-06523257GO:1902495
GeneOntologyCellularComponenttransporter complex

SCN10A CYC1 CACNA1A SCN1A SCN2A SCN3A SCN9A

2.68e-06550257GO:1990351
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

4.45e-06378256GO:0034702
GeneOntologyCellularComponentplasma membrane protein complex

SCN10A CACNA1A CTNNA1 SCN1A SCN2A SCN3A SCN9A

2.73e-05785257GO:0098797
GeneOntologyCellularComponentmembrane protein complex

SCN10A CYC1 CACNA1A CTNNA1 DERL1 SCN1A SCN2A SCN3A SCN9A

3.47e-051498259GO:0098796
GeneOntologyCellularComponentaxon

SCN10A ATP7A SCN1A SCN2A SCN3A NTS SCN9A

6.11e-05891257GO:0030424
GeneOntologyCellularComponentintercalated disc

CTNNA1 SCN1A SCN2A

7.19e-0568253GO:0014704
GeneOntologyCellularComponentcell-cell contact zone

CTNNA1 SCN1A SCN2A

1.88e-0494253GO:0044291
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A

2.57e-0420252GO:0033268
GeneOntologyCellularComponentpresynaptic membrane

SCN10A CACNA1A SCN1A SCN2A

3.06e-04277254GO:0042734
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A

5.47e-0429252GO:0043194
GeneOntologyCellularComponentcell body

CACNA1A ATP7A CCT3 SCN1A SCN3A NTS

6.49e-04929256GO:0044297
GeneOntologyCellularComponentneuronal cell body

CACNA1A ATP7A SCN1A SCN3A NTS

2.74e-03835255GO:0043025
GeneOntologyCellularComponentpresynapse

SCN10A CACNA1A SCN1A SCN2A NTS

3.54e-03886255GO:0098793
GeneOntologyCellularComponentT-tubule

SCN1A SCN2A

4.00e-0379252GO:0030315
GeneOntologyCellularComponentsynaptic membrane

SCN10A CACNA1A SCN1A SCN2A

4.75e-03583254GO:0097060
GeneOntologyCellularComponentmain axon

SCN1A SCN2A

5.05e-0389252GO:0044304
HumanPhenoProgressive gait ataxia

CACNA1A PSAP SCN1A SCN2A SCN9A

3.84e-0930125HP:0007240
HumanPhenoProgressive ataxia

CACNA1A PSAP SCN1A SCN2A SCN9A

3.84e-0930125HP:0001329
HumanPhenoFacial tics

CACNA1A SCN1A SCN2A SCN9A

2.38e-0815124HP:0011468
HumanPhenoComplex febrile seizure

CACNA1A SCN1A SCN2A SCN9A

3.17e-0816124HP:0011172
HumanPhenoAbnormal autonomic nervous system physiology

SCN10A CACNA1A ATP7A PSAP SCN3A SCN9A

2.01e-07130126HP:0012332
HumanPhenoLimited knee extension

ATP7A SCN1A SCN2A SCN9A

3.01e-0727124HP:0003066
HumanPhenoStatus epilepticus with prominent motor symptoms

CACNA1A SCN1A SCN2A SCN9A

4.07e-0729124HP:0032658
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

5.56e-078123HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

5.56e-078123HP:0200048
HumanPhenoClonic seizure

PSAP SCN1A SCN2A SCN3A SCN9A

6.52e-0781125HP:0020221
HumanPhenoGeneralized clonic seizure

PSAP SCN1A SCN2A SCN9A

7.89e-0734124HP:0011169
HumanPhenoLimitation of knee mobility

ATP7A SCN1A SCN2A SCN9A

8.89e-0735124HP:0010501
HumanPhenoLimitation of neck motion

CACNA1A SCN1A SCN2A SCN9A

9.99e-0736124HP:0005986
HumanPhenoDisturbance of facial expression

CACNA1A SCN1A SCN2A SCN9A

9.99e-0736124HP:0005324
HumanPhenoAbnormal neck physiology

CACNA1A SCN1A SCN2A SCN9A

9.99e-0736124HP:0025669
HumanPhenoLimited neck range of motion

SCN1A SCN2A SCN9A

1.63e-0611123HP:0000466
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A SCN9A

2.17e-0612123HP:0012847
HumanPhenoFocal automatism seizure

CACNA1A SCN1A SCN2A

2.17e-0612123HP:0032898
HumanPhenoAtypical absence seizure

CACNA1A SCN1A SCN2A SCN9A

2.73e-0646124HP:0007270
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A SCN9A

2.82e-0613123HP:0007058
HumanPhenoStatus epilepticus

CACNA1A PSAP SCN1A SCN2A SCN3A SCN9A

3.16e-06207126HP:0002133
HumanPhenoRigidity

CACNA1A PSAP SCN1A SCN2A SCN3A SCN9A

3.83e-06214126HP:0002063
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A SCN9A

4.47e-0615123HP:0007207
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A SCN9A

5.50e-0616123HP:0025101
HumanPhenoFocal impaired awareness seizure

CACNA1A SCN1A SCN2A SCN3A SCN9A

5.90e-06126125HP:0002384
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A SCN9A

6.67e-0617123HP:0011151
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A SCN9A

6.67e-0617123HP:0032663
HumanPhenoFocal motor seizure

CACNA1A PSAP SCN1A SCN2A SCN9A

7.14e-06131125HP:0011153
HumanPhenoVisually-induced seizure

SCN1A SCN2A SCN9A

7.99e-0618123HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A

7.99e-0618123HP:0032860
HumanPhenoTonic seizure

CACNA1A PSAP SCN1A SCN2A SCN9A

9.90e-06140125HP:0032792
HumanPhenoGeneralized tonic seizure

CACNA1A SCN1A SCN2A SCN9A

1.04e-0564124HP:0010818
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A

1.11e-0520123HP:0032671
HumanPhenoInfection-related seizure

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.18e-05145125HP:0032892
HumanPhenoSeizure precipitated by febrile infection

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.18e-05145125HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.18e-05145125HP:0002373
HumanPhenoTalipes valgus

SCN1A SCN2A SCN9A

1.30e-0521123HP:0004684
HumanPhenoGeneralized myoclonic seizure

CACNA1A PSAP SCN1A SCN2A SCN9A

1.30e-05148125HP:0002123
HumanPhenoImpulsivity

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.34e-05149125HP:0100710
HumanPhenoEEG with generalized epileptiform discharges

CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A

1.48e-05270126HP:0011198
HumanPhenoReflex seizure

SCN1A SCN2A SCN9A

1.50e-0522123HP:0020207
HumanPhenoTibial torsion

SCN1A SCN2A SCN9A

1.72e-0523123HP:0100694
HumanPhenoDevelopmental regression

CACNA1A ATP7A PSAP SCN1A SCN2A SCN3A SCN9A

1.85e-05440127HP:0002376
HumanPhenoFocal hemiclonic seizure

SCN1A SCN2A SCN9A

2.23e-0525123HP:0006813
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A

2.83e-0527123HP:0011171
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A SCN9A

2.83e-0527123HP:0031475
HumanPhenoAlien limb phenomenon

CACNA1A SCN1A

3.04e-054122HP:0032506
HumanPhenoFocal manual automatism seizure

CACNA1A SCN1A

3.04e-054122HP:0032900
HumanPhenoFocal pedal automatism seizure

CACNA1A SCN1A

3.04e-054122HP:0032901
HumanPhenoDissociated sensory loss

CACNA1A SCN1A

3.04e-054122HP:0010835
HumanPhenoFocal aware seizure

SCN1A SCN2A SCN9A

3.17e-0528123HP:0002349
HumanPhenoAbnormal knee physiology

ATP7A SCN1A SCN2A SCN9A

3.54e-0587124HP:0034670
HumanPhenoAbnormal facial expression

CACNA1A ATP7A SCN1A SCN2A SCN9A

3.85e-05185125HP:0005346
HumanPhenoHypsarrhythmia

CACNA1A ATP7A SCN1A SCN2A SCN3A

3.85e-05185125HP:0002521
HumanPhenoInterictal epileptiform activity

CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A

3.85e-05319126HP:0011182
HumanPhenoInterictal EEG abnormality

CACNA1A ATP7A SCN1A SCN2A SCN3A SCN9A

4.29e-05325126HP:0025373
HumanPhenoCogwheel rigidity

SCN1A SCN2A SCN9A

4.77e-0532123HP:0002396
HumanPhenoAtonic seizure

CACNA1A SCN1A SCN2A SCN9A

4.81e-0594124HP:0010819
HumanPhenoSeesaw nystagmus

CACNA1A SCN1A

5.07e-055122HP:0012044
HumanPhenoSpontaneous pain sensation

CACNA1A SCN1A

5.07e-055122HP:0010833
HumanPhenoAllodynia

SCN10A SCN9A

5.07e-055122HP:0012533
HumanPhenoEncephalopathy

CYC1 CACNA1A PSAP SCN1A SCN2A SCN3A

5.09e-05335126HP:0001298
HumanPhenoObsessive-compulsive trait

SCN1A SCN2A SCN9A

5.24e-0533123HP:0008770
HumanPhenoAbnormality of temperature sensation

CACNA1A SCN1A SCN9A

5.74e-0534123HP:0100772
HumanPhenoImpaired temperature sensation

CACNA1A SCN1A SCN9A

5.74e-0534123HP:0010829
HumanPhenoCalcaneovalgus deformity

SCN1A SCN2A SCN9A

5.74e-0534123HP:0001848
HumanPhenoAbnormality of the autonomic nervous system

SCN10A CACNA1A ATP7A PSAP SCN3A SCN9A

6.12e-05346126HP:0002270
HumanPhenoFocal-onset seizure

CACNA1A PSAP SCN1A SCN2A SCN3A SCN9A

6.12e-05346126HP:0007359
HumanPhenoDeformed tarsal bones

SCN1A SCN2A SCN9A

6.27e-0535123HP:0008119
HumanPhenoAction tremor

CACNA1A PSAP SCN1A SCN2A SCN9A

7.10e-05210125HP:0002345
HumanPhenoAbnormal tibia morphology

ATP7A SCN1A SCN2A SCN9A

8.00e-05107124HP:0002992
HumanPhenoMyoclonus

CACNA1A PSAP SCN1A SCN2A SCN3A SCN9A

9.09e-05371126HP:0001336
HumanPhenoHyperkinetic movements

PSAP SCN1A SCN2A

9.40e-0540123HP:0002487
HumanPhenoFocal non-motor seizure

CACNA1A SCN1A SCN2A

9.40e-0540123HP:0032679
HumanPhenoAbnormality of pain sensation

SCN10A CACNA1A SCN1A SCN9A

9.91e-05113124HP:0010832
HumanPhenoGeneralized-onset motor seizure

CACNA1A PSAP SCN1A SCN2A SCN9A

1.05e-04228125HP:0032677
HumanPhenoFocal clonic seizure

SCN1A SCN2A SCN9A

1.09e-0442123HP:0002266
HumanPhenoEEG with focal epileptiform discharges

CACNA1A SCN1A SCN2A SCN9A

1.17e-04118124HP:0011185
HumanPhenoPsychomotor regression

CYC1 CACNA1A PSAP SCN1A SCN2A SCN3A

1.20e-04390126HP:0002489
HumanPhenoMental deterioration

CYC1 CACNA1A PSAP SCN1A SCN2A SCN3A

1.20e-04390126HP:0001268
HumanPhenoEpileptic encephalopathy

CACNA1A SCN1A SCN2A SCN3A

1.21e-04119124HP:0200134
HumanPhenoMotor seizure

CACNA1A ATP7A PSAP SCN1A SCN2A SCN3A SCN9A

1.21e-04586127HP:0020219
HumanPhenoPoor head control

CACNA1A ATP7A PSAP SCN2A SCN3A

1.22e-04235125HP:0002421
HumanPhenoBilateral tonic-clonic seizure

CACNA1A PSAP SCN1A SCN2A SCN3A SCN9A

1.27e-04394126HP:0002069
HumanPhenoFirst dorsal interossei muscle weakness

CACNA1A SCN1A

1.41e-048122HP:0003392
HumanPhenoChorea

CACNA1A ATP7A PSAP SCN1A SCN2A

1.57e-04248125HP:0002072
HumanPhenoAbnormal hippocampus morphology

SCN1A SCN2A SCN9A

1.63e-0448123HP:0025100
HumanPhenoDialeptic seizure

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.66e-04251125HP:0011146
HumanPhenoAbnormal morphology of the limbic system

SCN1A SCN2A SCN9A

1.73e-0449123HP:0007343
HumanPhenoPallor

CACNA1A ATP7A PSAP SCN1A SCN2A SCN9A

1.75e-04417126HP:0000980
HumanPhenoAbnormal exteroceptive sensation

SCN10A CACNA1A PSAP SCN1A SCN9A

1.93e-04259125HP:0033747
HumanPhenoMyoclonic seizure

CACNA1A PSAP SCN1A SCN2A SCN9A

2.04e-04262125HP:0032794
HumanPhenoBilateral tonic-clonic seizure with focal onset

PSAP SCN1A SCN2A

2.07e-0452123HP:0007334
HumanPhenoBilateral tonic-clonic seizure with generalized onset

SCN1A SCN2A SCN9A

2.07e-0452123HP:0025190
HumanPhenoGait ataxia

CACNA1A PSAP SCN1A SCN2A SCN9A

2.07e-04263125HP:0002066
HumanPhenoGlobal brain atrophy

PSAP SCN1A SCN2A SCN9A

2.16e-04138124HP:0002283
HumanPhenoParkinsonism

PSAP SCN1A SCN2A SCN9A

2.16e-04138124HP:0001300
HumanPhenoEEG with generalized sharp slow waves

CACNA1A SCN1A

2.27e-0410122HP:0011199
HumanPhenoDecreased vigilance

CACNA1A SCN1A

2.27e-0410122HP:0032044
HumanPhenoErythromelalgia

SCN10A SCN9A

2.27e-0410122HP:0032147
MousePhenotonic seizures

DGKE ATP7A PSAP SCN1A

4.66e-0825214MP:0002826
MousePhenoabnormal action potential

SCN10A CACNA1A SCN1A SCN2A SCN9A

1.30e-06133215MP:0005402
MousePhenoconvulsive seizures

CACNA1A DGKE ATP7A PSAP SCN1A

2.60e-06153215MP:0000947
MousePhenoseizures

CACNA1A DGKE ATP7A PSAP SCN1A SCN9A

1.09e-05360216MP:0002064
MousePhenoimpaired limb coordination

CACNA1A ATP7A PSAP

9.00e-0559213MP:0001524
MousePhenoabnormal nervous system electrophysiology

SCN10A CACNA1A SCN1A SCN2A SCN9A

1.05e-04329215MP:0002272
MousePhenoabnormal brain wave pattern

SCN10A CACNA1A SCN1A

1.15e-0464213MP:0004994
MousePhenoimpaired ability to fire action potentials

SCN10A SCN1A

1.66e-0413212MP:0002578
MousePhenoclonic seizures

CACNA1A SCN1A

1.93e-0414212MP:0003996
MousePhenoabnormal cerebellar granule layer morphology

CACNA1A ATP7A PSAP

2.67e-0485213MP:0000886
MousePhenoabnormal brainstem morphology

CACNA1A ATP7A PSAP SCN2A

3.26e-04227214MP:0005277
MousePhenoabnormal hippocampus granule cell layer

PSAP SCN1A

4.02e-0420212MP:0008285
MousePhenoabnormal posture

SCN10A CACNA1A ATP7A SCN1A

4.22e-04243214MP:0001504
MousePhenoabnormal spike wave discharge

CACNA1A SCN1A

5.82e-0424212MP:0008840
MousePhenoabnormal habituation

PSAP SCN1A

5.82e-0424212MP:0011617
MousePhenoataxia

CACNA1A ATP7A PSAP SCN1A

5.94e-04266214MP:0001393
MousePhenoparalysis

CACNA1A ATP7A PSAP

7.15e-04119213MP:0000753
MousePhenoabnormal nonassociative learning

PSAP SCN1A

7.38e-0427212MP:0011616
MousePhenoapnea

SCN10A SCN1A

7.38e-0427212MP:0001957
MousePhenoimpaired balance

CACNA1A ATP7A PSAP

7.51e-04121213MP:0001525
MousePhenoabnormal enzyme/coenzyme activity

CACNA1A ATP7A PSAP OR2L13

7.90e-04287214MP:0005584
MousePhenoabnormal tail movements

SCN10A PSAP

8.52e-0429212MP:0001391
MousePhenoperinatal lethality

CACNA1A ATP7A PSAP SCN1A SCARB1 SCN2A SCN9A

9.36e-041130217MP:0002081
MousePhenoabnormal breathing pattern

SCN10A ATP7A SCN1A SCN2A

9.68e-04303214MP:0001951
MousePhenoabnormal seizure response to electrical stimulation

SCN1A SCN9A

1.04e-0332212MP:0001650
MousePhenoweight loss

ATP7A PSAP SCN1A SCN2A

1.08e-03312214MP:0001263
MousePhenoabnormal channel response

CACNA1A SCN2A

1.10e-0333212MP:0003484
MousePhenoabnormal single cell response

SCN10A SCN9A

1.24e-0335212MP:0003463
MousePhenoabsence seizures

CACNA1A SCN1A

1.24e-0335212MP:0003216
MousePhenoabnormal mechanical nociception

SCN10A SCN9A

1.31e-0336212MP:0002734
MousePhenoabnormal stationary movement

SCN10A PSAP SCN1A

1.32e-03147213MP:0001388
MousePhenohindlimb paresis

ATP7A PSAP

1.39e-0337212MP:0031204
MousePhenoabnormal respiratory system physiology

SCN10A CACNA1A ATP7A PSAP SCN1A SCN2A

1.62e-03897216MP:0002133
MousePhenoabnormal respiration

SCN10A CACNA1A ATP7A SCN1A SCN2A

1.62e-03598215MP:0001943
MousePhenononconvulsive seizures

CACNA1A SCN1A

1.62e-0340212MP:0000948
MousePhenoabnormal RR interval

SCN10A SCN1A SCARB1

1.68e-03160213MP:0010504
MousePhenotremors

CACNA1A ATP7A PSAP SCN1A

1.70e-03353214MP:0000745
MousePhenoabnormal thermal nociception

SCN10A CACNA1A SCN9A

1.93e-03168213MP:0002733
MousePhenohypoalgesia

SCN10A CACNA1A SCN9A

2.00e-03170213MP:0003043
MousePhenoabnormal cerebellar granule cell morphology

CACNA1A PSAP

2.05e-0345212MP:0004098
MousePhenolethality at weaning, complete penetrance

CACNA1A PSAP

2.14e-0346212MP:0011083
MousePhenoabnormal heart electrocardiography waveform feature

SCN10A CCT3 SCN1A SCARB1

2.17e-03377214MP:0010508
MousePhenoimpaired righting response

SCN10A CACNA1A SCN1A

2.35e-03180213MP:0001523
MousePhenoabnormal response to social novelty

SCN1A SCN2A

2.42e-0349212MP:0020395
MousePhenoabnormal CNS synaptic transmission

CACNA1A DGKE PSAP SCN1A SCN2A SCN9A

2.61e-03985216MP:0002206
MousePhenoabnormal respiratory function

SCN10A ATP7A SCN1A SCN2A

2.66e-03399214MP:0002327
MousePhenoabnormal impulse conducting system conduction

SCN10A CCT3 SCN1A SCARB1

2.69e-03400214MP:0003137
MousePhenoparesis

ATP7A PSAP

2.83e-0353212MP:0000754
MousePhenodecreased thermal nociceptive threshold

SCN10A CACNA1A

2.93e-0354212MP:0003998
MousePhenoabnormal righting response

SCN10A CACNA1A SCN1A

2.95e-03195213MP:0002862
MousePhenoprolonged QT interval

CCT3 SCN1A

3.04e-0355212MP:0003233
MousePhenoabnormal seizure response to inducing agent

CACNA1A SCN1A SCN9A

3.22e-03201213MP:0009357
MousePhenoabnormal postural reflex

SCN10A CACNA1A SCN1A

3.31e-03203213MP:0002980
MousePhenoabnormal Purkinje cell morphology

CACNA1A ATP7A PSAP

3.36e-03204213MP:0000877
MousePhenostereotypic behavior

CACNA1A PSAP SCN1A

3.84e-03214213MP:0001408
MousePhenoabnormal cerebellar molecular layer

CACNA1A PSAP

3.85e-0362212MP:0000889
MousePhenoabnormal noradrenaline level

CACNA1A ATP7A

3.85e-0362212MP:0003964
MousePhenopostnatal lethality, complete penetrance

CACNA1A ATP7A SCN1A SCN2A

3.94e-03445214MP:0011085
MousePhenoabnormal synaptic transmission

CACNA1A DGKE PSAP SCN1A SCN2A SCN9A

3.96e-031070216MP:0003635
MousePhenoabnormal synaptic physiology

CACNA1A DGKE PSAP SCN1A SCN2A SCN9A

4.07e-031076216MP:0021009
MousePhenoabnormal cerebellar Purkinje cell layer

CACNA1A ATP7A PSAP

4.15e-03220213MP:0000875
MousePhenodecreased kidney weight

ATP7A PSAP

4.35e-0366212MP:0003918
MousePhenoshort stride length

CACNA1A PSAP

4.75e-0369212MP:0001407
DomainNa_channel_asu

SCN10A SCN1A SCN2A SCN3A SCN9A

8.72e-1310265IPR001696
DomainNa_trans_assoc

SCN10A SCN1A SCN2A SCN3A SCN9A

8.72e-1310265IPR010526
DomainNa_trans_assoc

SCN10A SCN1A SCN2A SCN3A SCN9A

8.72e-1310265PF06512
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN9A

4.42e-116264PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN9A

4.42e-116264IPR024583
DomainChannel_four-helix_dom

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

1.35e-1057266IPR027359
Domain-

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

1.35e-10572661.20.120.350
DomainIon_trans_dom

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

9.44e-09114266IPR005821
DomainIon_trans

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

9.44e-09114266PF00520
DomainIQ_motif_EF-hand-BS

SCN10A SCN1A SCN2A SCN3A SCN9A

1.41e-0790265IPR000048
DomainIQ

SCN10A SCN1A SCN2A SCN3A SCN9A

1.66e-0793265PS50096
DomainIQ

SCN10A SCN1A SCN3A SCN9A

2.69e-0671264PF00612
DomainIQ

SCN1A SCN2A SCN3A SCN9A

4.56e-0681264SM00015
DomainEF-hand-dom_pair

SCN1A SCN3A SCN9A

7.19e-03287263IPR011992
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN10A SCN1A SCN2A SCN3A SCN9A

1.51e-0931245M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN10A SCN1A SCN2A SCN3A SCN9A

1.79e-0932245M27455
PathwayREACTOME_L1CAM_INTERACTIONS

SCN10A SCN1A SCN2A SCN3A SCN9A

1.60e-06121245M872
PathwayREACTOME_CARDIAC_CONDUCTION

SCN10A SCN1A SCN2A SCN3A SCN9A

2.28e-06130245M27454
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A

1.38e-0528243M45519
PathwayREACTOME_MUSCLE_CONTRACTION

SCN10A SCN1A SCN2A SCN3A SCN9A

2.00e-05203245M5485
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

SCN2A SCN3A SCN9A

6.69e-0547243M42524
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

CACNA1A SCN1A SCN3A

2.49e-0473243MM16641
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

SCN10A SCN1A SCN2A SCN3A SCN9A

3.29e-04367245M48346
PathwayREACTOME_SENSORY_PERCEPTION

OR2T12 OR2T33 OR2L13 SCN2A SCN3A SCN9A

5.52e-04636246M41834
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN10A SCN1A SCN2A SCN3A SCN9A

1.14e-15627523652591
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN10A SCN1A SCN2A SCN3A SCN9A

2.39e-14927516382098
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN10A SCN1A SCN2A SCN3A SCN9A

2.44e-131327515123669
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A SCN9A

1.44e-1252748812438
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

4.17e-10327319284629
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

4.17e-10327312610651
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

4.17e-10327333895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

4.17e-10327323859570
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN10A SCN3A SCN9A

4.17e-10327319699781
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

4.17e-10327314973256
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

4.17e-10327318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

4.17e-10327317544618
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

1.67e-09427317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

1.67e-09427335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

1.67e-09427329578003
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

1.67e-09427335801810
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN10A SCN1A SCN9A

1.67e-09427322260870
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

1.67e-0942738974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

4.17e-0952731679748
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

4.17e-09527324337656
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN10A SCN3A SCN9A

1.46e-08727324440715
Pubmed

Significant determinants of mouse pain behaviour.

SCN10A SCN3A SCN9A

2.33e-08827325101983
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN10A SCN3A SCN9A

3.49e-0892738854872
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A

3.49e-08927315746173
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN10A CACNA1A SCN1A SCN3A SCN9A

7.13e-0813927516985003
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

9.14e-08122738169823
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A

9.14e-081227330175250
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

1.89e-07152739726281
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

5.80e-07227229649454
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

5.80e-07227220346423
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

5.80e-07227226311622
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

5.80e-07227210827969
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

5.80e-07227215249644
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

5.80e-07227227690330
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

5.80e-07227219694741
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

5.80e-07227211245985
Pubmed

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

SCN10A SCN9A

5.80e-07227216111501
Pubmed

Inherited neuronal ion channelopathies: new windows on complex neurological diseases.

CACNA1A SCN1A

5.80e-07227219005038
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

5.80e-07227221377452
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

5.80e-0722721317301
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

5.80e-07227223965409
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

5.80e-07227223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

5.80e-07227227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

5.80e-07227233096315
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

5.80e-07227224990319
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

5.80e-07227225172946
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

5.80e-07227231439038
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

5.80e-07227230693367
Pubmed

Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.

SCN1A SCN2A

1.74e-06327219270815
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

SCN1A SCN2A

1.74e-06327228784306
Pubmed

Familial Hemiplegic Migraine

CACNA1A SCN1A

1.74e-06327220301562
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

1.74e-06327216052353
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

1.74e-06327232185219
Pubmed

Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.

SCN10A SCN9A

1.74e-06327238999942
Pubmed

Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine.

CACNA1A SCN1A

1.74e-06327218056581
Pubmed

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.

SCN10A SCN9A

1.74e-06327215314237
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

1.74e-06327232005694
Pubmed

The cell and molecular basis of mechanical, cold, and inflammatory pain.

SCN10A SCN9A

1.74e-06327218669863
Pubmed

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.

SCN1A SCN2A

1.74e-06327225155934
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A

1.74e-06327217928448
Pubmed

The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.

CACNA1A SCN1A

1.74e-06327229486580
Pubmed

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

SCN10A SCN9A

1.74e-06327230554136
Pubmed

Sodium channels and mammalian sensory mechanotransduction.

SCN10A SCN9A

1.74e-06327222449024
Pubmed

Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.

SCN10A SCN9A

1.74e-06327222875917
Pubmed

Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.

SCN10A SCN3A

1.74e-06327217052333
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A

1.74e-06327232845893
Pubmed

FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.

CACNA1A SCN1A

1.74e-06327219007941
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A

1.74e-06327228518218
Pubmed

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.

SCN10A SCN9A

1.74e-06327228074005
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

1.74e-06327227816501
Pubmed

Higher burden of rare frameshift indels in genes related to synaptic transmission separate familial hemiplegic migraine from common types of migraine.

CACNA1A SCN1A

1.74e-06327231980564
Pubmed

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.

SCN10A SCN9A

3.48e-06427238172636
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

SCN1A SCN2A

3.48e-06427226637798
Pubmed

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.

SCN10A SCN9A

3.48e-06427227604420
Pubmed

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.

SCN10A SCN9A

3.48e-06427222531176
Pubmed

Evolution and diversity of mammalian sodium channel genes.

SCN10A SCN9A

3.48e-06427210198179
Pubmed

Genetic studies of Polish migraine patients: screening for causative mutations in four migraine-associated genes.

CACNA1A SCN1A

3.48e-06427226747084
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A

3.48e-06427221156207
Pubmed

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes.

SCN10A SCN9A

3.48e-06427239163201
Pubmed

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.

SCN10A SCN9A

5.80e-06527237117223
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN3A SCN9A

5.80e-06527222875929
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A

5.80e-06527217724025
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN10A SCN9A

8.69e-06627216029194
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN10A SCN3A

8.69e-06627223711479
Pubmed

Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.

SCN3A SCN9A

8.69e-0662729143501
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A

1.22e-05727225818041
Pubmed

A role for Piezo2 in EPAC1-dependent mechanical allodynia.

SCN10A SCN9A

1.22e-05727223575686
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SCN2A SCN3A

2.30e-05712738751373
Pubmed

Common variants associated with general and MMR vaccine-related febrile seizures.

SCN1A SCN2A

2.60e-051027225344690
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

SCN1A SCN2A

2.60e-051027220602612
Pubmed

Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.

SCN10A SCN9A

4.50e-051327235904071
Pubmed

Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.

PTH NTS

8.81e-051827211278902
Pubmed

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.

SCN10A SCN9A

1.21e-042127225369838
Pubmed

Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.

CACNA1A PSAP

1.86e-042627235165395
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

CTNNA1 ATP7A DEPDC1B SCARB1

1.96e-0437727438117590
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

CACNA1A DGKE SCN1A SCN9A

2.57e-0440527438187761
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

DGKE ATP7A HEATR5B SCARB1

5.87e-0450427434432599
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CYC1 DGKE CTNNA1 HEATR5B DERL1

7.09e-0494227531073040
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

DGKE CTNNA1 ATP7A CCT3 SCARB1

7.44e-0495227538569033
InteractionSCN11A interactions

SCN10A CACNA1A SCN1A SCN9A

3.45e-0915274int:SCN11A
InteractionCACNA1D interactions

SCN10A CACNA1A SCN1A SCN9A

2.66e-0824274int:CACNA1D
InteractionSCN1A interactions

SCN10A CACNA1A SCN1A SCN9A

5.93e-0829274int:SCN1A
InteractionSCN10A interactions

SCN10A CACNA1A SCN1A

3.51e-0711273int:SCN10A
InteractionSCN5A interactions

SCN10A CACNA1A SCN1A SCN9A

4.38e-0747274int:SCN5A
InteractionNALCN interactions

CACNA1A SCN1A SCN9A

7.73e-0714273int:NALCN
InteractionCACNA1C interactions

CACNA1A DERL1 SCN1A SCN9A

1.27e-0661274int:CACNA1C
InteractionOR2T12 interactions

OR2T12 OR2T33

1.73e-062272int:OR2T12
InteractionSCN9A interactions

CACNA1A SCN1A SCN9A

2.81e-0621273int:SCN9A
InteractionOR2T33 interactions

OR2T12 OR2T33

5.18e-063272int:OR2T33
InteractionCACNA1B interactions

CACNA1A SCN1A SCN9A

1.62e-0537273int:CACNA1B
InteractionCACNA1A interactions

SCN10A CACNA1A SCN1A SCN9A

2.08e-05123274int:CACNA1A
InteractionSCN4B interactions

SCN1A SCN2A

4.82e-058272int:SCN4B
InteractionNEDD4L interactions

SCN10A SCN1A SCN2A SCN3A SCN9A

5.93e-05320275int:NEDD4L
InteractionRDH8 interactions

CCT3 PRAME

7.73e-0510272int:RDH8
InteractionANK3 interactions

CTNNA1 CCT3 SCN1A SCN2A

1.41e-04201274int:ANK3
InteractionHRAS interactions

DGKE CTNNA1 ATP7A RHPN2 DEPDC1B SCARB1

3.29e-04725276int:HRAS
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A SCN9A

9.33e-07127274chr2q24
Cytoband2q24

SCN3A SCN9A

1.83e-05112722q24
Cytoband1q44

OR2T12 OR2T33 OR2L13

3.75e-051102731q44
Cytoband2q24.3

SCN1A SCN2A

3.98e-05162722q24.3
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T12 OR2T33 OR2L13

5.90e-05128273chr1q44
CytobandEnsembl 112 genes in cytogenetic band chr8q24

CYC1 DERL1

1.84e-02355272chr8q24
GeneFamilySodium voltage-gated channel alpha subunits

SCN10A SCN1A SCN2A SCN3A SCN9A

2.06e-1392251203
GeneFamilyOlfactory receptors, family 2

OR2T12 OR2T33 OR2L13

3.36e-04113223149
GeneFamilyEndogenous ligands

PSAP PTH NTS

2.85e-03237223542
CoexpressionAtlasBM Top 100 - thalamus

SCN1A SCN2A NTS

4.59e-0562243BM Top 100 - thalamus
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.01e-072002654fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.01e-07200265f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.01e-07200265cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.01e-07200265310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.01e-07200265c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A SCN1A SCN2A SCN3A SCN9A

1.01e-07200265961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1A SCN1A SCN2A SCN3A

1.91e-0615526477fdae85d36efb776db977eb424b32487ef222e4
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRAME SCN1A SCN3A NTS

2.69e-06169264f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRAME SCN1A SCN3A NTS

2.76e-0617026435e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRAME SCN1A SCN3A NTS

2.76e-061702640ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRAME SCN1A SCN3A NTS

2.76e-061702640b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTH DEPDC1B SCN2A SCN3A

3.09e-06175264787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A SCN2A SCN3A NTS

3.16e-061762642e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

OR2T33 DEPDC1B SCN2A SCN3A

3.38e-06179264666072c0e8448dbaec1683d18368ec2502453f90
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

CACNA1A SCN2A SCN3A SCN9A

4.37e-0619126476311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A SCN1A SCN2A SCN3A

5.04e-06198264c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A SCN1A SCN2A SCN3A

5.04e-061982646d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A SCN1A SCN2A SCN3A

5.04e-061982644ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN10A SCN1A SCN9A

8.07e-0514526396712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

OR2T12 SCN2A SCN3A

8.24e-05146263e887e9de895fd453faa703997ef372cc6410fc49
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN1A SCN2A

9.10e-05151263f41c6558a5874b6464c157027fdf202257c60e5b
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A SCN2A SCN3A

1.06e-041592637747cef94c55144fddcd024a7495318357f1351b
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.10e-04161263133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.10e-04161263cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.10e-041612639466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.12e-0416226396c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.16e-041642637a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.16e-041642635e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.16e-04164263f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.16e-041642634cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.18e-04165263347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.18e-041652631890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.18e-04165263507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A NTS

1.18e-0416526339a25be081a5d59c7cf107a997d352793d5025fb
ToppCellmild_COVID-19_(asymptomatic)-pDC|World / disease group, cell group and cell class (v2)

OR2L13 SCARB1 SCN9A

1.23e-04167263bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

OR2L13 SCARB1 SCN9A

1.25e-04168263968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCellsevere-HSPC|World / disease stage, cell group and cell class

C9orf43 SCN2A SCN9A

1.27e-04169263b0421b73bfdc92f7a2762b4b670b9eae124aa702
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A SCN2A NTS

1.29e-0417026302f0be0aab8ba2d35a83238609352ef3677511c9
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNA1 SCARB1 SCN3A

1.34e-041722637fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNA1 SCARB1 SCN3A

1.34e-041722632a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A SCN3A NTS

1.36e-0417326307798461d12d04f3dabff03481c999cb07c5af2f
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A SCN2A SCN3A

1.38e-04174263a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1A C9orf43 ATP7A

1.41e-0417526312f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A SCN3A NTS

1.43e-04176263fb718a6b07aa5d56600263280afa530bcb63db42
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.46e-04177263dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCellASK454-Endothelial-Lymphatic|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CACNA1A SCN3A NTS

1.51e-04179263fd84a79f76a01c0377dff5b20016b004d369f96f
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SCN1A SCN2A SCN3A

1.51e-04179263af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN3A NTS

1.53e-041802639db9899ca42455310e9b63df523fe6c4780abfb7
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CACNA1A SCN2A SCN3A

1.53e-0418026357689ccbbd44c0e78e061edd87d3102c5f2dcc9a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.53e-04180263401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell10x5'-bone_marrow-Myeloid_Mac-Macrophage|bone_marrow / Manually curated celltypes from each tissue

CTNNA1 PSAP SCARB1

1.56e-04181263d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CACNA1A SCN2A SCN3A

1.58e-0418226357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.58e-041822635f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

RHPN2 SCN2A SCN3A

1.61e-0418326315d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.61e-041832632e831a4d99c6f983793df71c0994124c943c6da9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PSAP SCN2A SCN3A

1.63e-041842639690d4290e70f9bda889754ffb30b0af1f7cb94b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.63e-041842637d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN3A NTS

1.66e-041852632a8104f610fa5ce618f8105521616722462a0d42
ToppCell18-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

CACNA1A SCN2A SCN3A

1.66e-04185263f8fc7b12b4e18d23d84e95488be93c4352d325f3
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A ATP7A SCN3A

1.66e-04185263bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.69e-041862637278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SCN10A PSAP SCN2A

1.69e-0418626323b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A SCN2A SCN3A

1.69e-04186263b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellfacs-Heart-LA-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTH SCARB1 NTS

1.71e-04187263b0768a0102d533bc6c9efe56b7a9c18db7a374b7
ToppCellfacs-Heart-LA-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTH SCARB1 NTS

1.71e-0418726387d4323a72e96ce35f9981faa92ded846a474384
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.71e-04187263f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.74e-04188263eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SCN3A SCN9A

1.74e-041882631f912ea015f50570e848259d948a0ba682d64bb4
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

DEPDC1B SCN2A SCN3A

1.74e-041882631d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SCN2A SCN3A SCN9A

1.74e-04188263b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A SCN2A SCN3A

1.74e-04188263c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.74e-04188263bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell21-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

CACNA1A SCN2A SCN3A

1.74e-04188263e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

DEPDC1B SCN2A SCN3A

1.74e-04188263df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.77e-041892637eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.77e-04189263e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellCOVID-19-lung-Lymphatic_EC|lung / Disease (COVID-19 only), tissue and cell type

SCN3A NTS SCN9A

1.77e-04189263c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.77e-04189263f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DEPDC1B SCN2A SCN3A

1.77e-04189263975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SCN2A SCN3A

1.79e-0419026340d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SCN2A SCN3A

1.79e-04190263f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

SCN2A SCN3A SCN9A

1.79e-041902636e92c78799f34b31d098854503c796edb0dc7f80
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A SCN2A SCN3A

1.79e-04190263a9a705455019e28d655636de73b07540798f82e6
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SCN3A NTS SCN9A

1.85e-041922635f4f44f15d3a2846981e68296643a4634930a211
ToppCellfacs-Heart-LA-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTH SCARB1 NTS

1.85e-041922635238506f2bb8bd36a49d3012442f45063c0550e6
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SCN3A NTS SCN9A

1.85e-041922635e709c0714e8eba27e03a6def0544256bedb3ced
ToppCellCOVID-19-lung-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SCN3A NTS SCN9A

1.85e-04192263cbe57cda44232b183821ac633b60a2668265e616
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.88e-04193263be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.88e-041932630c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.88e-041932638689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCN1A SCN2A

1.88e-041932635fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell(6)_Endothelial_cells-(6)_Endothelial-F_(Lymphatics)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

SCN3A NTS SCN9A

1.91e-041942639441202d6fa2ffbef9277d48ae9bc98876c26ec5
ToppCelldistal-2-Endothelial-Lymphatic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SCN3A NTS SCN9A

1.94e-041952638e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SCN3A NTS SCN9A

1.94e-04195263fc75f04eb475c8139cc5c35e6be22e73fb2be9e6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A SCN1A SCN2A

1.94e-04195263787e95fb59c40bba784544b662fac37606ae1427
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SCN3A NTS SCN9A

1.94e-0419526383d45ff5e5bc704448431149fffb2e4c1278f279
ToppCelldistal-Endothelial-Lymphatic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SCN3A NTS SCN9A

1.94e-04195263f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCell(08)_PNEC|World / shred by cell type and Timepoint

CACNA1A SCN3A SCN9A

1.97e-041962632ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCelldistal-Endothelial-Lymphatic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SCN3A NTS SCN9A

1.97e-041962633e8a20e1d163dcbd3bbd99fe179d54af02298af0
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1A SCN1A SCN2A

1.97e-04196263671c380b58d7f634b4fbec38c357d357ea4f3535
DrugZonisamide

SCN1A SCN2A SCN3A SCN9A

2.66e-0917254DB00909
DrugAPETx1, Anthopleura elegantissima

SCN10A SCN2A SCN3A

2.33e-086253ctd:C475726
Drugfenpropathrin

SCN10A SCN2A SCN3A

2.33e-086253ctd:C044267
DrugNSC7524

SCN10A CACNA1A SCN2A SCN3A NTS SCN9A

3.75e-08182256CID000005657
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN10A SCN2A SCN3A

6.52e-088253ctd:C489827
Drugbenzocaine

SCN10A SCN2A SCN3A SCN9A

7.28e-0837254CID000002337
DrugTetrodotoxin

SCN2A SCN3A NTS SCN9A

1.01e-0740254ctd:D013779
Drugphenytoin

SCN10A CACNA1A PTH SCN2A SCN3A SCN9A

1.12e-07219256CID000001775
Druglamotrigine

SCN10A CACNA1A SCN2A SCN3A SCN9A

1.54e-07116255CID000003878
Drugsaxitoxin

SCN10A SCN2A SCN3A SCN9A

7.31e-0765254CID000037165
DrugGBR 12909

SCN10A SCN3A NTS SCN9A

9.31e-0769254CID000003455
DrugScorpion Venoms

SCN2A SCN3A SCN9A

9.44e-0718253ctd:D012604
Druggabapentin

SCN10A CACNA1A SCN3A NTS SCN9A

1.00e-06169255CID000003446
Drugdiprafenone

SCN10A SCN3A SCN9A

1.12e-0619253CID000071249
Drugdiphenhydramine

SCN10A SCN3A NTS SCN9A

1.30e-0675254CID000003100
DrugSodium

SCN10A SCN2A SCN3A SCN9A

2.06e-0684254ctd:D012964
DrugAC1Q6NIK

ATP7A PTH NTS

2.33e-0624253CID000065939
DrugAC1NT1AF

SCN10A SCN3A SCN9A

2.65e-0625253CID005322157
DrugPirmenolum

SCN10A SCN3A SCN9A

2.99e-0626253CID000004853
DrugAC1L1MOZ

SCN10A SCN3A SCN9A

3.36e-0627253CID000031958
Drugnefopam

SCN10A SCN3A SCN9A

3.36e-0627253CID000004450
DrugPbTx-1

SCN10A SCN3A SCN9A

3.36e-0627253CID006437089
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN9A

3.47e-063252ctd:C561228
Drugparaben

SCN10A SCN3A SCN9A

3.76e-0628253CID000007175
Drugpentobarbital

SCN10A PTH SCN3A NTS SCN9A

3.99e-06224255CID000004737
Drugisradipine

SCN10A CACNA1A SCN3A SCN9A

4.13e-06100254CID000003784
Drugcyfluthrin

SCN10A SCN2A SCN3A

4.19e-0629253ctd:C052570
Drugtocainide

SCN10A SCN3A SCN9A

4.66e-0630253CID000038945
Drugsodium

SCN10A CYC1 PTH SCN2A SCN3A NTS SCN9A SLC5A4

4.89e-06944258CID000000923
Drugtetradotoxin

SCN10A CACNA1A SCN2A SCN3A NTS SCN9A

5.57e-06428256CID000020382
DrugNSC93767

SCN10A SCN3A SCN9A

5.68e-0632253CID000005658
Drug5-hydroxypropafenone

SCN10A SCN3A SCN9A

6.84e-0634253CID000107927
DrugAPETx2 protein, Anthopleura elegantissima

SCN10A SCN2A

6.94e-064252ctd:C501880
DrugLidocaine

SCN10A SCN9A

6.94e-064252DB00281
Drughydrochlorothiazide

SCN10A PTH SCN3A SCN9A

8.52e-06120254CID000003639
Drugaprindine

SCN10A SCN3A SCN9A

9.62e-0638253CID000002218
Drugbepridil

SCN10A CACNA1A SCN3A SCN9A

1.03e-05126254CID000002351
Drugtriphosphoinositide

SCN10A DGKE PTH SCN3A SCN9A

1.04e-05273255CID009543520
DrugS-ropivacaine

SCN10A SCN3A SCN9A

1.12e-0540253CID000071273
Drugisoprodian

ATP7A PTH

1.16e-055252CID003037188
DrugY11038

PSAP NTS

1.16e-055252CID000012765
Drugclenbuterol

SCN10A PRAME SCN3A SCN9A

1.66e-05142254CID000002783
Drugpilsicainide

SCN10A SCN3A SCN9A

1.72e-0546253CID000004820
Drugspiradoline

SCN10A SCN3A SCN9A

1.72e-0546253CID000005620
DrugRSR13

ATP7A PTH SCN2A

1.84e-0547253CID000122335
Drugdecamethrin

SCN10A SCN1A SCN2A SCN3A

1.85e-05146254ctd:C017180
Drugindoxacarb

SCN10A SCN3A SCN9A

2.08e-0549253CID000107720
Drugprocaine

SCN10A CACNA1A SCN3A SCN9A

2.22e-05153254CID000004914
Drugsodiosodium

PTH SCN2A SCN3A

2.80e-0554253CID000141233
DrugAC1NSN3X

SCN10A SCN3A SCN9A

2.80e-0554253CID005366189
DrugL-threonine amide

PSAP PTH

3.23e-058252CID000444078
DrugBT-PABA

PRAME PTH NTS

3.29e-0557253CID000002329
Drugtriamterene

SCN10A SCN3A SCN9A

3.47e-0558253CID000005546
Drugriluzole

SCN10A CACNA1A SCN3A SCN9A

3.68e-05174254CID000005070
Drugfenfluramine

SCN10A ATP7A SCN3A SCN9A

4.02e-05178254CID000003337
Drugcarbamazepine

SCN10A SCN2A SCN3A SCN9A

4.11e-05179254CID000002554
DrugMexiletine

SCN10A SCN9A

4.15e-059252ctd:D008801
Drugzonisamide

SCN10A SCN3A SCN9A

4.24e-0562253CID000005734
DrugAC1L1CQC

SCN10A SCN3A SCN9A

4.88e-0565253CID000002012
Drugmexiletine

SCN10A SCN3A SCN9A

5.11e-0566253CID000004178
Drugresiniferatoxin

SCN10A SCN3A SCN9A

5.11e-0566253CID000104826
Drugdisopyramide

SCN10A SCN3A SCN9A

5.11e-0566253CID000003114
Drugpropofol

SCN10A PTH SCN3A SCN9A

5.29e-05191254CID000004943
DrugPhenytoin

PTH SCN1A SCARB1 SCN2A SCN3A

5.42e-05385255ctd:D010672
Drugdibucaine

SCN10A SCN3A SCN9A

5.59e-0568253CID000003025
DrugBezafibrate [41859-67-0]; Up 200; 11uM; PC3; HT_HG-U133A

CACNA1A SCN1A SCARB1 SCN2A

5.96e-051972546653_UP
DrugT2755

SCN10A SCN3A SCN9A

6.36e-0571253CID000005514
Drugflecainide

SCN10A SCN3A SCN9A

6.36e-0571253CID000003355
Drugimide

SCN10A SCN3A SCN9A

7.20e-0574253CID000443040
Drug1, 3-diallylurea

SCN10A SCN3A SCN9A

7.20e-0574253CID000074537
Drugsorbitan

CYC1 PSAP

7.59e-0512252CID000103023
DrugTetracaine

SCN10A SCN9A

7.59e-0512252ctd:D013748
Drugpotassium

SCN10A CACNA1A PTH SCN2A SCN3A NTS SCN9A

7.78e-051008257CID000000813
Drug2N3NAD

PTH NTS

8.96e-0513252CID000164223
Drugbupropion

SCN10A SCN3A SCN9A

9.43e-0581253CID000000444
Drugcarisbamate

PTH SCN2A

1.38e-0416252CID006918474
DrugPD 150606

SCN2A SCN3A

1.56e-0417252ctd:C100442
Drugfenvalerate

SCN10A SCN2A SCN3A

1.61e-0497253ctd:C017690
Drugpropafenone

SCN10A SCN3A SCN9A

1.66e-0498253CID000004932
Drugverapamil

SCN10A CACNA1A PTH SCN3A SCN9A

1.68e-04490255CID000002520
Drugtrimethoprim

SCN10A SCN3A SCN9A

1.71e-0499253CID000005578
Drugketamine

SCN10A PTH SCN3A SCN9A

1.79e-04262254CID000003821
Drughexafluorobenzene

ATP7A SCN2A

1.96e-0419252CID000009805
DrugAC1NRC8M

SCN2A SCN3A

1.96e-0419252CID005288877
DrugN-acetyl-L-aspartate

CACNA1A PTH SCN3A

2.04e-04105253CID000065065
Drugpyraclofos

CACNA1A SCN2A SCN9A

2.09e-04106253CID000093460
DrugAC1O5FLX

ATP7A PTH

2.17e-0420252CID006433117
DrugNicorette

SCN10A CACNA1A SCN3A NTS SCN9A

2.40e-04529255CID000000942
Drug3-iodo-4-hydroxybenzoic acid

CACNA1A SCN2A

2.64e-0422252CID000449473
DrugPL 0

ATP7A NTS

3.15e-0424252CID000016157
DrugAC1L2IZE

ATP7A NTS

3.15e-0424252CID000072928
Drugavanafil

ATP7A PTH

3.15e-0424252CID009869929
Drugbupivacaine

SCN10A SCN3A SCN9A

3.40e-04125253CID000002474
DrugMulticide

SCN2A SCN9A

3.42e-0425252CID000024365
Drugconivaptan

ATP7A PTH

3.42e-0425252CID000151171
Drugtalnetant

PTH NTS

3.42e-0425252CID000133090
DrugCaspofungin [inn]

ATP7A PTH

4.00e-0427252CID000151068
DrugGTP[S]

SCN10A CACNA1A PTH SCN3A SCN9A

4.00e-04591255CID000001764
Drug2MbisP

PTH NTS

4.30e-0428252CID005289547
DrugCAAC

ATP7A PTH

4.61e-0429252CID006436397
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN10A SCN1A SCN2A SCN3A SCN9A

7.17e-1410255DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN10A SCN1A SCN2A SCN3A SCN9A

7.17e-1410255DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN10A SCN1A SCN2A SCN3A SCN9A

2.25e-1312255DOID:0060170 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

2.90e-0922254DOID:2030 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SCN10A CACNA1A SCN1A SCN2A SCN3A SCN9A

4.21e-09163256DOID:1826 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A SCN9A

4.50e-089253C3502809
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

1.53e-0713253C0751122
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

6.89e-072252C4551549
DiseaseFamilial or sporadic hemiplegic migraine

CACNA1A SCN1A

2.07e-063252cv:CN295307
DiseaseFamilial hemiplegic migraine

CACNA1A SCN1A

2.07e-063252cv:C0338484
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN10A SCN9A

2.07e-063252C1833661
DiseasePrimary Erythermalgia

SCN10A SCN9A

2.07e-063252C0014805
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN10A SCN9A

1.44e-057252C0020075
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.44e-057252C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.44e-057252C0751057
DiseaseCongenital Pain Insensitivity

SCN10A SCN9A

1.44e-057252C0002768
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

1.92e-058252C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

1.92e-058252C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

1.92e-058252C0338479
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

1.92e-058252C0438414
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

1.92e-058252C0751120
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

1.92e-058252C0393703
DiseaseFebrile Convulsions

SCN1A SCN2A

2.47e-059252C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

2.47e-059252C0014550
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

3.09e-0510252C0917800
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

3.77e-0511252C0393702
DiseaseMMR-related febrile seizures

SCN1A SCN2A

7.19e-0515252EFO_0006519
DiseaseNeuralgia, Supraorbital

SCN10A SCN9A

8.21e-0516252C0038870
DiseaseNeuralgia, Iliohypogastric Nerve

SCN10A SCN9A

8.21e-0516252C0423712
DiseaseNeuralgia, Perineal

SCN10A SCN9A

8.21e-0516252C0423711
DiseaseTremor, Rubral

CACNA1A ATP7A

8.21e-0516252C0750940
DiseaseAtaxia, Appendicular

CACNA1A ATP7A

8.21e-0516252C0750937
DiseaseNeuralgia

SCN10A SCN9A

8.21e-0516252C0027796
DiseaseAtaxia, Motor

CACNA1A ATP7A

8.21e-0516252C0278161
DiseaseAbnormal coordination

CACNA1A ATP7A

8.21e-0516252C0520966
DiseaseAtaxia, Truncal

CACNA1A ATP7A

8.21e-0516252C0427190
DiseaseNeuralgia, Atypical

SCN10A SCN9A

8.21e-0516252C0234247
DiseaseNeuralgia, Stump

SCN10A SCN9A

8.21e-0516252C0234249
DiseaseParoxysmal Nerve Pain

SCN10A SCN9A

8.21e-0516252C0751373
DiseaseNerve Pain

SCN10A SCN9A

8.21e-0516252C0751372
DiseaseNeuralgia, Ilioinguinal

SCN10A SCN9A

8.21e-0516252C0751371
DiseaseNeuralgia, Vidian

SCN10A SCN9A

8.21e-0516252C0042656
DiseaseAtaxia, Sensory

CACNA1A ATP7A

8.21e-0516252C0240991
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

8.21e-0516252C0393706
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

1.05e-0418252HP_0002373
DiseaseEpilepsy

SCN1A SCN2A SCN9A

1.06e-04109253C0014544
DiseaseAtaxia

CACNA1A ATP7A

2.04e-0425252C0004134
DiseaseAnemia

ATP7A PTH

3.80e-0434252C0002871
Diseaseheart failure

HEATR5B PRAME SCARB1

5.04e-04185253EFO_0003144
DiseaseInherited neuropathies

ATP7A SCN9A

5.27e-0440252C0598589
DiseaseQRS complex, QRS duration

SCN10A HEATR5B

6.67e-0445252EFO_0005054, EFO_0005055

Protein segments in the cluster

PeptideGeneStartEntry
IMAMIALNTIVLMMK

CACNA1A

1571

O00555
MRMMARICLNKEMPP

DEPDC1B

331

Q8WUY9
KMLMMMALLVPLVYT

CYC1

291

P08574
CIPVMGLMIYMMVMD

ATP7A

661

Q04656
LMDMMLVSTTVPKMA

OR2T12

66

Q8NG77
MDMQLLMIPLIMSVL

DERL1

116

Q9BUN8
LMDMMLVSTTVPKMA

OR2T33

66

Q8NG76
MSVMKPCLMTIAILM

DEFB116

1

Q30KQ4
MMAGMKIQLVCMLLL

NTS

1

P30990
KLMTPIECAMTMMSH

HEATR5B

636

Q9P2D3
DIIVLAKQMCMIMME

CTNNA1

711

P35221
QTMLCPEMKIKLAMM

C9orf43

226

Q8TAL5
TVRLILKCSMMPMQV

DGKE

506

P52429
YPIRMSKMMCVKMIG

OR2L13

131

Q8N349
FAMPMQDIKMILKMV

PRAME

216

P78395
IMVLICLNMVTMMVE

SCN9A

1521

Q15858
MCAYLKLLPMFLMVM

SLC5A4

316

Q9NY91
VMMENKPMTLKLIMT

SCARB1

146

Q8WTV0
IIRTCLGPKSMMKML

CCT3

36

P49368
SIMILICLNMVTMMV

SCN3A

1531

Q9NY46
MSPAMLSVLVKMMLA

RHPN2

271

Q8IUC4
SIMILICLNMVTMMV

SCN1A

1546

P35498
TIMVLICLNMITMMV

SCN10A

1481

Q9Y5Y9
SIMILICLNMVTMMV

SCN2A

1536

Q99250
MSPAMLSVLVKMMLT

RHPN2P1

186

A8MT19
IAIQMMMHMQPKEIC

PSAP

251

P07602
MIPAKDMAKVMIVML

PTH

1

P01270