Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD4 RGPD2 RANBP2 RASGRF2 STXBP5 ARHGEF5 TBC1D5 RAP1GAP2 ARHGAP39 PLEKHG4B PLEKHG1 RIN1 DLC1 RGPD3 AGAP1

5.42e-0750712315GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD4 RGPD2 RANBP2 RASGRF2 STXBP5 ARHGEF5 TBC1D5 RAP1GAP2 ARHGAP39 PLEKHG4B PLEKHG1 RIN1 DLC1 RGPD3 AGAP1

5.42e-0750712315GO:0030695
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 RGPD2 RANBP2 STXBP5 TBC1D5 RAP1GAP2 ARHGAP39 RIN1 DLC1 RGPD3 AGAP1

1.26e-0627912311GO:0005096
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD2 RANBP2 RGPD3 UHRF2

2.64e-06361235GO:0019789
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD2 RANBP2 RGPD3

6.15e-06201234GO:0061665
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD2 RANBP2 RGPD3

2.54e-04501234GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD2 RANBP2 RGPD3

3.18e-04531234GO:0016859
GeneOntologyMolecularFunctionGTPase binding

RGPD4 RGPD2 RANBP2 SH3GL1 STRIP1 PLEKHG1 RIN1 BNIP3 RGPD3

3.95e-043601239GO:0051020
GeneOntologyMolecularFunctionenzyme activator activity

RGPD4 RGPD2 RANBP2 STXBP5 TBC1D5 RAP1GAP2 ARHGAP39 CCNT1 RIN1 DLC1 RGPD3 AGAP1

7.41e-0465612312GO:0008047
GeneOntologyMolecularFunctionprolactin receptor binding

GH1 GH2

7.75e-0471232GO:0005148
GeneOntologyMolecularFunctionsodium channel inhibitor activity

RSC1A1 NEDD4

1.03e-0381232GO:0019871
GeneOntologyMolecularFunctionenzyme regulator activity

RGPD4 RGPD2 RANBP2 RASGRF2 STXBP5 ARHGEF5 TBC1D5 RAP1GAP2 ARHGAP39 SSPOP PLEKHG4B PLEKHG1 CCNT1 RIN1 PPP2R3A DLC1 UMODL1 RGPD3 AGAP1

1.07e-03141812319GO:0030234
GeneOntologyMolecularFunctionmolecular adaptor activity

GPHN PHF24 NACA NUP98 DYRK1A IRAK2 ICE1 DCC SPATA2 SNAP47 STRIP1 CCNT1 PPP2R3A MIDN TLE2 TLE4 KDM7A KIR2DL4

1.62e-03135612318GO:0060090
GeneOntologyMolecularFunctiongrowth hormone receptor binding

GH1 GH2

1.64e-03101232GO:0005131
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD2 RANBP2 MIDN RGPD3

8.61e-09131235GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD2 RANBP2 MIDN RGPD3

1.33e-08141235GO:1903299
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD2 RANBP2 RGPD3

1.48e-0791234GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD2 RANBP2 RGPD3

2.46e-07101234GO:1903301
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD2 RANBP2 RGPD3

5.42e-06201234GO:0006607
GeneOntologyBiologicalProcessregulation of kinase activity

RGPD4 RGPD2 RANBP2 MCPH1 ARHGEF5 DTNBP1 MAP3K4 GH1 CCNT1 MIDN RGPD3 KIF14 MLLT1 TNFAIP3 MAP2K6

1.46e-0568612315GO:0043549
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

CDC42BPA RASGRF2 ARHGEF5 RAP1GAP2 ARHGAP39 ITGB1 PLEKHG4B PLEKHG1 DLC1 KIF14

3.14e-0533312310GO:0051056
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD2 RANBP2 RGPD3

7.60e-05381234GO:0000413
GeneOntologyBiologicalProcessprotein localization to organelle

RGPD4 GPHN RGPD2 RANBP2 LRWD1 MCPH1 ZFYVE16 FAM53A NACA NUP98 DYRK1A TEX15 NEDD4 PYHIN1 RGPD3 TNFAIP3 GOLGB1 NOL8

8.25e-05109112318GO:0033365
GeneOntologyBiologicalProcessregulation of transferase activity

RGPD4 RGPD2 RANBP2 MCPH1 ARHGEF5 DTNBP1 MAP3K4 GH1 CCNT1 MIDN RGPD3 KIF14 MLLT1 TNFAIP3 MAP2K6

9.70e-0581012315GO:0051338
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD4 RGPD2 RANBP2 FAM53A NUP98 DYRK1A RGPD3

1.71e-041951237GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD4 RGPD2 RANBP2 FAM53A NUP98 DYRK1A RGPD3

2.06e-042011237GO:0051170
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.60e-09101235GO:0044614
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

5.24e-08181235GO:0044615
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD2 RANBP2 RGPD3

7.85e-0881234GO:1990723
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

9.39e-08201235GO:0042405
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD2 RANBP2 RGPD3

1.09e-06141234GO:0005642
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD2 RANBP2 RGPD3

6.32e-06211234GO:0106068
GeneOntologyCellularComponentinclusion body

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.92e-04901235GO:0016234
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

3.28e-041011235GO:0005643
GeneOntologyCellularComponenttranscription elongation factor complex

ICE1 CCNT1 ELL2 MLLT1

3.31e-04561234GO:0008023
GeneOntologyCellularComponentgrowth hormone receptor complex

GH1 GH2

5.07e-0461232GO:0070195
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

STXBP5 SH3GL1 DTNBP1 SNAP47

6.57e-04671234GO:0098686
GeneOntologyCellularComponentneuron to neuron synapse

GPHN STXBP5 SH3GL1 DCC DTNBP1 SNAP47 ITGB1 BNIP3 RNF10 INSYN2B

1.06e-0352312310GO:0098984
GeneOntologyCellularComponentchromosome, centromeric region

LRWD1 ERCC6L NUP98 NDEL1 MKI67 SKA3 UHRF2

1.25e-032761237GO:0000775
GeneOntologyCellularComponentactin filament

PRICKLE4 INPP5D DYRK1A SPECC1 DLC1

1.73e-031461235GO:0005884
GeneOntologyCellularComponentasymmetric synapse

GPHN SH3GL1 DCC DTNBP1 SNAP47 ITGB1 BNIP3 RNF10 INSYN2B

2.06e-034771239GO:0032279
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

STXBP5 SH3GL1 DCC DTNBP1 ITGB1

2.25e-031551235GO:0098685
GeneOntologyCellularComponentcondensed chromosome

LRWD1 ERCC6L NUP98 LIG3 NDEL1 MKI67 SKA3

2.29e-033071237GO:0000793
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD2 RANBP2 LIG3 RGPD3

6.28e-0816985MP:0003701
MousePhenoabnormal tumor latency

RGPD4 FOXO3 RGPD2 RANBP2 RGPD3 TREM1

1.17e-0734986MP:0010307
MousePhenodecreased tumor latency

RGPD4 FOXO3 RGPD2 RANBP2 RGPD3

1.89e-0630985MP:0010308
MousePhenoabnormal morula morphology

RGPD4 RGPD2 RANBP2 RGPD3

3.02e-0526984MP:0012058
MousePhenofailure of blastocyst formation

RGPD4 RGPD2 RANBP2 RGPD3

6.18e-0531984MP:0012129
DomainRan_BP1

RGPD4 RGPD2 RANBP2 RGPD3

8.79e-07121244PF00638
DomainRANBD1

RGPD4 RGPD2 RANBP2 RGPD3

8.79e-07121244PS50196
DomainRanBD

RGPD4 RGPD2 RANBP2 RGPD3

1.26e-06131244SM00160
DomainRan_bind_dom

RGPD4 RGPD2 RANBP2 RGPD3

1.26e-06131244IPR000156
DomainRab_bind

RGPD4 RGPD2 RGPD3

9.80e-0671243PF16704
DomainGCC2_Rab_bind

RGPD4 RGPD2 RGPD3

9.80e-0671243IPR032023
Domain-

RGPD4 RGPD2 RGPD3

3.31e-051012431.10.220.60
DomainGrip

RGPD4 RGPD2 RGPD3

4.53e-05111243SM00755
DomainGRIP

RGPD4 RGPD2 RGPD3

4.53e-05111243PF01465
DomainC8

VWF SSPOP MUC2

6.02e-05121243PF08742
DomainTIL

VWF SSPOP MUC2

6.02e-05121243PF01826
DomainGRIP_dom

RGPD4 RGPD2 RGPD3

6.02e-05121243IPR000237
DomainGRIP

RGPD4 RGPD2 RGPD3

6.02e-05121243PS50913
DomainUnchr_dom_Cys-rich

VWF SSPOP MUC2

7.78e-05131243IPR014853
DomainC8

VWF SSPOP MUC2

7.78e-05131243SM00832
DomainTIL_dom

VWF SSPOP MUC2

9.86e-05141243IPR002919
DomainVWF_type-D

VWF SSPOP MUC2

1.50e-04161243IPR001846
DomainVWFD

VWF SSPOP MUC2

1.50e-04161243PS51233
DomainVWD

VWF SSPOP MUC2

1.50e-04161243SM00216
DomainVWD

VWF SSPOP MUC2

1.50e-04161243PF00094
DomainCTCK_1

VWF SSPOP MUC2

2.17e-04181243PS01185
DomainVWC_out

VWF SSPOP MUC2

2.56e-04191243SM00215
Domain-

RGPD4 RGPD2 RANBP2 CDC42BPA RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1 RGPD3 AGAP1

2.83e-04391124102.30.29.30
DomainZnf_PHD

PHF24 PHRF1 ASH1L KDM7A UHRF2

3.51e-04911245IPR001965
DomainZF_PHD_2

PHF24 PHRF1 ASH1L KDM7A UHRF2

4.28e-04951245PS50016
DomainGroucho_enhance

TLE2 TLE4

4.32e-0451242IPR009146
DomainTLE_N

TLE2 TLE4

4.32e-0451242PF03920
DomainGroucho/TLE_N

TLE2 TLE4

4.32e-0451242IPR005617
DomainSomatotropin_CS

GH1 GH2

4.32e-0451242IPR018116
DomainZnf_FYVE_PHD

ZFYVE16 PHF24 PHRF1 ASH1L KDM7A UHRF2

4.47e-041471246IPR011011
DomainZF_PHD_1

PHF24 PHRF1 ASH1L KDM7A UHRF2

4.49e-04961245PS01359
DomainPH_dom-like

RGPD4 RGPD2 RANBP2 CDC42BPA RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1 RGPD3 AGAP1

5.54e-0442612410IPR011993
DomainCys_knot_C

VWF SSPOP MUC2

5.90e-04251243IPR006207
DomainCTCK_2

VWF SSPOP MUC2

5.90e-04251243PS01225
DomainSOMATOTROPIN_2

GH1 GH2

6.45e-0461242PS00338
DomainSOMATOTROPIN_1

GH1 GH2

6.45e-0461242PS00266
DomainHormone_1

GH1 GH2

6.45e-0461242PF00103
DomainDH_1

RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1

8.15e-04631244PS00741
DomainSomatotropin

GH1 GH2

8.98e-0471242IPR001400
DomainLA

LARP4 LARP4B

8.98e-0471242SM00715
DomainHTH_LA

LARP4 LARP4B

8.98e-0471242PS50961
DomainLa

LARP4 LARP4B

8.98e-0471242PF05383
DomainLupus_La_RNA-bd

LARP4 LARP4B

8.98e-0471242IPR006630
DomainRhoGEF

RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1

1.09e-03681244SM00325
DomainRhoGEF

RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1

1.21e-03701244PF00621
DomainDH_2

RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1

1.21e-03701244PS50010
Domain-

RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1

1.28e-037112441.20.900.10
DomainDH-domain

RASGRF2 ARHGEF5 PLEKHG4B PLEKHG1

1.28e-03711244IPR000219
DomainPHD

PHRF1 ASH1L KDM7A UHRF2

1.56e-03751244PF00628
DomainVWFC_1

VWF SSPOP MUC2

1.74e-03361243PS01208
DomainZnf_PHD-finger

PHRF1 ASH1L KDM7A UHRF2

1.89e-03791244IPR019787
DomainVWFC_2

VWF SSPOP MUC2

2.03e-03381243PS50184
DomainVWC

VWF SSPOP MUC2

2.03e-03381243SM00214
DomainBAH

ASH1L BAHCC1

2.31e-03111242PS51038
DomainBAH_dom

ASH1L BAHCC1

2.31e-03111242IPR001025
DomainBAH

ASH1L BAHCC1

2.31e-03111242SM00439
DomainBAH

ASH1L BAHCC1

2.31e-03111242PF01426
DomainVWF_dom

VWF SSPOP MUC2

2.71e-03421243IPR001007
DomainPHD

PHRF1 ASH1L KDM7A UHRF2

2.93e-03891244SM00249
DomainTPR-contain_dom

RGPD4 RGPD2 RANBP2 ERCC6L RGPD3

3.27e-031501245IPR013026
DomainWD40_repeat_CS

LRWD1 STXBP5 TLE2 TLE4 KCTD3

4.78e-031641245IPR019775
DomainTPR_REGION

RGPD4 RGPD2 RANBP2 ERCC6L RGPD3

4.90e-031651245PS50293
DomainTPR

RGPD4 RGPD2 RANBP2 ERCC6L RGPD3

4.90e-031651245PS50005
DomainEMI

SSPOP UMODL1

5.57e-03171242PS51041
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

2.69e-06100877MM14561
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD2 RANBP2 RGPD3

3.88e-0618874MM1549
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

4.43e-0640875MM14945
PathwayREACTOME_CDC42_GTPASE_CYCLE

CDC42BPA RASGRF2 ARHGEF5 ARHGAP39 PLEKHG4B PLEKHG1 DLC1 KCTD3

4.99e-06155878M41808
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

5.02e-0641875MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

5.67e-0642875MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

6.38e-0643875MM14609
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

7.65e-06117877MM15387
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

RGPD4 RGPD2 RANBP2 CDC42BPA RASGRF2 ERCC6L ARHGEF5 NUP98 ARHGAP39 ITGB1 PLEKHG1 DLC1 NDEL1 RGPD3 KIF14

9.06e-066498715MM15690
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

9.97e-0647875MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.23e-0549875MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.36e-0550875MM14610
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

1.45e-05129877MM14894
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.50e-0551875MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

2.18e-0555875MM14917
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

2.59e-05141877MM15266
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

2.82e-0558875MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

2.82e-0558875MM14736
PathwayBIOCARTA_TFF_PATHWAY

ITGB1 GH1 GH2 MUC2

2.86e-0529874MM1522
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 CEP76 NDEL1 RGPD3

3.43e-05202878MM15362
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

4.92e-0565875MM15147
PathwayREACTOME_MITOTIC_PROPHASE

RGPD4 RGPD2 RANBP2 MCPH1 NUP98 RGPD3

7.26e-05114876MM15361
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

8.61e-0573875MM14948
PathwayREACTOME_RAC1_GTPASE_CYCLE

CDC42BPA RASGRF2 ARHGEF5 ARHGAP39 ITGB1 PLEKHG1 DLC1

1.02e-04175877MM15599
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

RANBP2 CDC42BPA RASGRF2 ERCC6L ARHGEF5 NUP98 ARHGAP39 ITGB1 PLEKHG4B PLEKHG1 DLC1 NDEL1 KCTD3 KIF14

1.22e-047208714M41838
PathwayREACTOME_RAC1_GTPASE_CYCLE

CDC42BPA RASGRF2 ARHGEF5 ARHGAP39 ITGB1 PLEKHG1 DLC1

1.40e-04184877M41809
PathwayKEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY

MPL GH1 GH2

1.45e-0417873M47905
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.50e-0482875MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.68e-0484875MM14929
PathwayREACTOME_RHO_GTPASE_EFFECTORS

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3 KIF14

1.85e-04257878MM14755
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.87e-0486875MM15413
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

1.88e-04193877MM14890
PathwayBIOCARTA_LONGEVITY_PATHWAY

FOXO3 GH1 GH2

2.05e-0419873MM1513
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

2.57e-0492875MM14951
PathwayREACTOME_CDC42_GTPASE_CYCLE

RASGRF2 ARHGEF5 ARHGAP39 PLEKHG1 DLC1

2.84e-0494875MM15598
PathwayWP_IL6_SIGNALING_PATHWAY

FOXO3 INPP5D MAP3K4 PPP2R3A MAP2K6

3.79e-04100875MM15826
PathwayBIOCARTA_TFF_PATHWAY

ITGB1 GH1 MUC2

4.18e-0424873M15926
PathwayREACTOME_RHO_GTPASE_CYCLE

CDC42BPA RASGRF2 ARHGEF5 ARHGAP39 ITGB1 PLEKHG4B PLEKHG1 DLC1 KCTD3 KIF14

4.42e-044508710M27078
PathwayBIOCARTA_AKT_PATHWAY

FOXO3 GH1 GH2

5.33e-0426873MM1345
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

6.01e-04234877MM14898
PathwayREACTOME_SUMOYLATION

RGPD4 RGPD2 RANBP2 NUP98 RGPD3 UHRF2

6.15e-04169876MM14919
PathwayREACTOME_M_PHASE

RGPD4 RGPD2 RANBP2 MCPH1 ERCC6L NUP98 CEP76 NDEL1 RGPD3

6.26e-04387879MM15364
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

GH1 GH2

7.75e-047872M47646
PathwayREACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

FOXO3 RANBP2 ZEB1 INPP5D NUP98 IRAK2 IL18BP ITGB1 NEDD4 GH1 GH2 IFI30 MAP2K6

1.05e-037898713M1060
PathwayREACTOME_NOD1_2_SIGNALING_PATHWAY

IRAK2 TNFAIP3 MAP2K6

1.40e-0336873M1059
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

RGPD4 RGPD2 RANBP2 ERCC6L NUP98 NDEL1 RGPD3

1.42e-03271877MM15388
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE2 TLE4

1.64e-0310872MM15156
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RANBP2 ERCC6L NUP98 ITGB1 NDEL1

1.73e-03140875M27550
PathwayWP_MALE_INFERTILITY

LRWD1 CDC42BPA TEX15 CCNT1 MTHFR

2.02e-03145875M39856
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZFYVE16 STXBP5 PHF24 RAP1GAP2 POGZ SPATA2 STRIP1 MAP3K4 NEDD4 PLEKHG1 TLE4 SPHKAP MAST1 PCDH10 PDZD2

3.25e-114071281512693553
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GPHN FOXO3 CDC42BPA ERCC6L ARHGEF5 TBC1D5 SH3GL1 DYRK1A SPECC1 CIC NEDD4 NHSL1 PLEKHG1 ZNF106 DLC1 RNF10 KIF14 TNFAIP3 SKA3 GOLGB1

5.83e-118611282036931259
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD4 RGPD2 RANBP2 ZEB1 ZFYVE16 ICE1 POGZ CIC ZNF592 TLE4 RGPD3 KIF14 SKA3 GOLGB1

5.31e-104181281434709266
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

7.84e-1013128531427429
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

RANBP2 LRWD1 CDC42BPA PCNX3 MRM1 NACA PHRF1 DYRK1A ICE1 ARHGAP39 SPECC1 CIC STRIP1 CCNT1 LARP4B ZNF592 RGPD3 KCTD3 KIF14 MLLT1 ZNF281 GOLGB1 AGAP1 NOL8

1.11e-0914971282431527615
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-09712849037092
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128411353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128430944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128438838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-09712847559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128417372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128438657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128421205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128418949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128425187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-09712848603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128426632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128424403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128423818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128423536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128412191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128422821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD2 RANBP2 RGPD3

6.07e-097128420682751
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD2 RANBP2 RGPD3

1.21e-088128421670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD2 RANBP2 RGPD3

1.21e-088128427412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD2 RANBP2 RGPD3

1.21e-088128421310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD2 RANBP2 RGPD3

1.21e-088128422262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD2 RANBP2 RGPD3

1.21e-088128428745977
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD2 RANBP2 RGPD3 MKI67

1.56e-0822128527717094
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-089128418394993
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-089128428100513
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-089128417887960
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-089128411553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-089128410601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-08912849733766
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD2 RANBP2 RGPD3

2.17e-089128428877029
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD2 RANBP2 RGPD3

3.61e-0810128427160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD2 RANBP2 RGPD3

3.61e-0810128416332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD2 RANBP2 RGPD3

3.61e-081012848857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD2 RANBP2 RGPD3

3.61e-0810128421859863
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD2 RANBP2 RGPD3

5.66e-0811128417069463
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD2 RANBP2 RGPD3

5.66e-0811128435771867
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD2 RANBP2 RGPD3

5.66e-0811128434110283
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GPHN RANBP2 ZFYVE16 ERCC6L TBC1D5 SH3GL1 NACA NUP98 ICE1 CIC CCNT1 LIG3 MKI67 SKA3 ZNF281 GOLGB1 NOL8

6.43e-089341281733916271
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ZFYVE16 ERCC6L NACA ICE1 NHLRC2 LARP4 SNAP47 ITGB1 STRIP1 ZNF106 LARP4B KIF14 CEP295 ZMYM1 SKA3

9.12e-087331281534672954
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

RANBP2 CDSN ERCC6L TBC1D5 LARP4 ITGB1 CCNT1 LIG3 ZNF106 RGPD3 ZMYM1 ZNF281

1.01e-074441281234795231
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FOXO3 LRWD1 CDC42BPA PCNX3 HECTD4 DYRK1A RAP1GAP2 ICE1 ZNF395 CIC NHSL1 PLEKHG1 ZNF592 MTHFR UCKL1 MLLT1 TNFAIP3 BAHCC1

1.34e-0711051281835748872
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD4 RGPD2 RANBP2 CDC42BPA NUP98 PPM1G LIG3 RGPD3 KIF14

1.72e-07226128937839992
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD2 RANBP2 RGPD3

2.32e-0715128414697343
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RGPD4 GPHN RGPD2 RANBP2 LRWD1 ERCC6L NACA NUP98 CEP76 POGZ SPECC1 STRIP1 ZNF106 NDEL1 RGPD3 MKI67 KIF14 ZMYM1

2.56e-0711551281820360068
Pubmed

A human MAP kinase interactome.

RANBP2 VWF CDC42BPA NUP98 RAP1GAP2 POGZ CIC MAP3K4 ZNF106 NDEL1 TNFAIP3 GOLGB1

2.66e-074861281220936779
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

2.84e-0738128512791264
Pubmed

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.

GH1 GH2 TLE2 TLE4

5.15e-0718128411731482
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

FOXO3 CDC42BPA MCPH1 TSHZ2 FAM53A TBC1D5 ASH1L HECTD4 ARHGAP39 LARP4 ITGB1 SSPOP PLEKHG4B PPP2R3A UCKL1 MAST1 ASTN2 GOLGB1 AGAP1 PDZD2

5.47e-0714891282028611215
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ARHGEF5 INPP5D TBC1D5 NUP98 MAGEE1 DTNBP1 CIC NEDD4 PLEKHG4B LARP4B ZMYM1

6.05e-074301281135044719
Pubmed

Interaction network of human early embryonic transcription factors.

RANBP2 ZEB1 NUP98 POGZ LIG3 TLE4 MKI67 UHRF2 ZNF281 BAHCC1

7.63e-073511281038297188
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD2 RANBP2 RGPD3 MKI67 UHRF2

8.16e-0786128637253089
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RANBP2 LRWD1 ZEB1 ERCC6L PHRF1 NUP98 POGZ ARHGAP39 CIC STRIP1 ZNF106 ZNF592 TLE4 MKI67

1.09e-067741281415302935
Pubmed

Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.

GH1 GH2 MKI67

1.69e-067128315456744
Pubmed

Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice.

FOXO3 GH1 GH2

1.69e-067128327771355
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD2 RGPD3

1.69e-067128315710750
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ARHGAP39 STRIP1 DLC1 SPHKAP CEP295 KDM7A

2.23e-06102128611214970
Pubmed

The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.

CCNT1 ELL2 MLLT1

2.69e-068128322483617
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RGPD4 GPHN RGPD2 RANBP2 KCNH7 CDC42BPA SH3GL1 NACA ARHGAP39 SNAP47 PPM1G NHSL1 LARP4B SPHKAP RGPD3 RNF10

4.73e-0611391281636417873
Pubmed

Human transcription factor protein interaction networks.

ZEB1 CDC42BPA NACA NUP98 POGZ SPATA2 LARP4 CIC PPM1G LIG3 LARP4B MIDN ZNF592 TLE4 MKI67 MLLT1 ZMYM1 ZNF281

5.23e-0614291281835140242
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

CDC42BPA NUP98 SPATA2 SNAP47 ITGB1 STRIP1 PPM1G PPP2R3A MKI67 PCDH10 GOLGB1 AGAP1 NOL8

6.27e-067771281335844135
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

RANBP2 NACA DYRK1A POGZ SPECC1 CCNT1 RGPD3 MKI67 ZNF281

7.46e-06357128937059091
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RANBP2 CDC42BPA ZFYVE16 TBC1D5 NUP98 ARHGAP39 DTNBP1 ITGB1 CIC PPM1G NHSL1 PPP2R3A KCTD3 MKI67 KIF14

7.77e-0610491281527880917
Pubmed

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.

CCNT1 ELL2 MLLT1

7.86e-0611128324367103
Pubmed

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function.

GH1 GH2 MKI67 MUC2

9.41e-0636128431781038
Pubmed

The little elongation complex regulates small nuclear RNA transcription.

ICE1 ELL2 MLLT1

1.05e-0512128322195968
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD4 GPHN RGPD2 RANBP2 ZEB1 TBC1D5 HECTD4 DYRK1A ARHGAP39 STRIP1 NEDD4 SPHKAP RGPD3 GOLGB1

1.33e-059631281428671696
Pubmed

The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II-induced dopaminergic neuron injury mouse model and by biochanin A.

FOXO3 SH3GL1

1.34e-052128234310897
Pubmed

The human growth hormone gene family: structure and evolution of the chromosomal locus.

GH1 GH2

1.34e-05212826306568
Pubmed

β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.

ITGB1 MKI67

1.34e-052128222869523
Pubmed

Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3.

FOXO3 ZEB1

1.34e-052128230304480
Pubmed

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.

VWF MUC2

1.34e-05212829407109
Pubmed

HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2.

RANBP2 NUP98

1.34e-052128221423673
Pubmed

Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.

FOXO3 LARP4

1.34e-052128232495863
Pubmed

Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle.

ZEB1 SKA3

1.34e-052128236728910
Pubmed

Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis.

VWF STXBP5

1.34e-052128221163921
Pubmed

Atbf1 is required for the Pit1 gene early activation.

GH1 GH2 MKI67

1.36e-0513128318272476
Pubmed

Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice.

DCC GH1 GH2

1.36e-0513128310559399
Pubmed

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

TBC1D5 MAP3K4 LARP4B ZNF592 RNF10

1.44e-058312859039502
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

LRWD1 ARHGEF5 POGZ CIC PPM1G CCNT1 LIG3 ZNF592 MKI67 UHRF2 ZNF281

1.64e-056081281136089195
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD4 RGPD2 RANBP2 POGZ RGPD3 ZNF281

1.76e-05146128623892456
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

RANBP2 POGZ CCNT1 ZNF106 MLLT1 ZNF281 NOL8

1.93e-05222128737071664
Pubmed

An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress.

GH1 GH2 MKI67

2.14e-0515128326292757
Pubmed

Cell proliferation and vascularization in mouse models of pituitary hormone deficiency.

GH1 GH2 MKI67

2.14e-0515128316556738
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RANBP2 LRWD1 MCPH1 PHRF1 NUP98 ZNF395 POGZ CIC ARL6IP4 LIG3 ZNF106 RGPD3 MKI67 MLLT1 ZNF281 NOL8

2.29e-0512941281630804502
Pubmed

Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man.

GH1 GH2 TLE4 MKI67

2.32e-0545128435951005
Pubmed

Opposing LSD1 complexes function in developmental gene activation and repression programmes.

ZEB1 GH1 GH2 MKI67

2.53e-0546128417392792
Pubmed

Interleukin-6 is dispensable in pituitary normal development and homeostasis but needed for pituitary stem cell activation following local injury.

GH1 GH2 MKI67

2.63e-0516128336619565
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CDC42BPA NACA PHRF1 HECTD4 ICE1 POGZ ZNF592 RNF10 KDM7A AGAP1

2.78e-055291281014621295
Pubmed

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

GPHN NUP98 RAP1GAP2 LARP4 RIN1 LARP4B

3.05e-05161128632572027
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

GPHN CDC42BPA RASGRF2 ARHGEF5 SH3GL1 NACA NUP98 ARHGAP39 PPM1G PLEKHG4B PLEKHG1 CCNT1 DLC1

3.51e-059161281332203420
Pubmed

Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development.

GH1 GH2 MKI67

3.82e-0518128317426285
Pubmed

TCF and Groucho-related genes influence pituitary growth and development.

GH1 GH2 TLE4

3.82e-0518128312907761
Pubmed

Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.

TLE2 TLE4 MKI67

3.82e-0518128333658226
Pubmed

Loss of Foxm1 Results in Reduced Somatotrope Cell Number during Mouse Embryogenesis.

GH1 GH2 MKI67

3.82e-0518128326075743
InteractionYWHAH interactions

FOXO3 CDC42BPA ERCC6L ARHGEF5 TBC1D5 SH3GL1 HECTD4 DYRK1A ZNF395 SPECC1 CIC NEDD4 PYHIN1 NHSL1 PLEKHG1 RIN1 ZNF106 RNF10 MAST1 KIF14 TNFAIP3 SKA3 AGAP1

3.59e-07110212723int:YWHAH
InteractionRGPD3 interactions

RGPD4 RGPD2 RANBP2 RGPD3 KIF14 SKA3

4.83e-07471276int:RGPD3
InteractionYWHAG interactions

GPHN FOXO3 CDC42BPA ERCC6L ARHGEF5 TBC1D5 SH3GL1 HECTD4 DYRK1A ZNF395 SPECC1 CIC NEDD4 PYHIN1 NHSL1 PLEKHG1 RIN1 ZNF106 DLC1 NDEL1 KIF14 TNFAIP3 SKA3 AGAP1

8.40e-07124812724int:YWHAG
InteractionRGPD4 interactions

RGPD4 RGPD2 RANBP2 RGPD3

1.01e-05221274int:RGPD4
InteractionRGPD1 interactions

RGPD4 RGPD2 RANBP2 NUP98 RGPD3

1.40e-05491275int:RGPD1
InteractionEGLN3 interactions

GPHN FOXO3 RANBP2 ZFYVE16 ERCC6L DYRK1A ICE1 NHLRC2 ARHGAP39 SNAP47 PPM1G NHSL1 CCNT1 ZNF106 NDEL1 KCTD3 RNF10 KIF14 MLLT1 CEP295 SKA3 ZNF281

1.87e-05129612722int:EGLN3
InteractionYWHAB interactions

FOXO3 CDC42BPA ARHGEF5 TBC1D5 HECTD4 DYRK1A ZNF395 SPECC1 ITGB1 CIC NEDD4 NHSL1 RIN1 ZNF106 MAST1 KIF14 TNFAIP3 MAP2K6 AGAP1

1.95e-05101412719int:YWHAB
InteractionH2AX interactions

FOXO3 RANBP2 MCPH1 NACA DYRK1A POGZ PPM1G PYHIN1 LIG3 ZNF592 MKI67 KIF14 MLLT1 UHRF2

2.29e-0559312714int:H2AX
InteractionRGPD2 interactions

RGPD4 RGPD2 RANBP2 RGPD3

2.36e-05271274int:RGPD2
InteractionYWHAZ interactions

FOXO3 CDSN CDC42BPA RASGRF2 ARHGEF5 TBC1D5 SH3GL1 HECTD4 RAP1GAP2 ZNF395 SPATA2 SPECC1 CIC MAP3K4 NEDD4 NHSL1 RIN1 NDEL1 MAST1 KIF14 TNFAIP3 AGAP1

2.44e-05131912722int:YWHAZ
InteractionMPG interactions

CDSN LARP4 CIC MIDN KIF14 UHRF2

3.65e-05981276int:MPG
InteractionRACK1 interactions

RGPD2 RANBP2 MCPH1 LARP4 RSC1A1 ITGB1 CIC MAP3K4 PYHIN1 LARP4B MIDN TLE2 MKI67 KIF14 MAP2K6

3.77e-0570412715int:RACK1
InteractionNUP43 interactions

RANBP2 LRWD1 PHRF1 ASH1L NUP98 ICE1 POGZ ARL6IP4 LIG3 ZNF592 MKI67 ZMYM1 ZNF281 PDZD2

4.06e-0562512714int:NUP43
InteractionDYNLL2 interactions

GPHN DYRK1A POGZ SPAG8 STRIP1 NHSL1 NDEL1 MAST1 GOLGB1

4.44e-052631279int:DYNLL2
InteractionELL2 interactions

ICE1 CCNT1 ELL2 MLLT1

5.34e-05331274int:ELL2
InteractionSLX4 interactions

RANBP2 CDSN NACA DYRK1A POGZ SPECC1 CCNT1 ZNF106 RGPD3 MKI67 MLLT1 ZNF281 NOL8

6.70e-0557212713int:SLX4
InteractionPPP2R1A interactions

FOXO3 ZEB1 SH3GL1 NACA NHLRC2 ARHGAP39 CIC STRIP1 NHSL1 PPP2R3A MKI67 MAST1 KIF14 SKA3

7.89e-0566512714int:PPP2R1A
InteractionKPNA4 interactions

RANBP2 DYRK1A CIC PYHIN1 PLEKHG4B CCNT1 RGPD3 MKI67

9.14e-052251278int:KPNA4
InteractionTOP3B interactions

FOXO3 LRWD1 CDC42BPA PCNX3 HECTD4 DYRK1A RAP1GAP2 ICE1 ZNF395 LARP4 CIC NHSL1 PLEKHG1 LIG3 LARP4B ZNF592 MTHFR UCKL1 KIF14 MLLT1 TNFAIP3 BAHCC1

1.22e-04147012722int:TOP3B
InteractionNAA40 interactions

GPHN RANBP2 ZFYVE16 ERCC6L TBC1D5 SH3GL1 NACA NUP98 ICE1 CIC CCNT1 LIG3 MKI67 SKA3 ZNF281 GOLGB1 NOL8

1.39e-0497812717int:NAA40
Cytoband10p11.2

ZEB1 ITGB1

2.14e-048128210p11.2
GeneFamilyPHD finger proteins

PHF24 PHRF1 ASH1L KDM7A UHRF2

5.84e-059083588
GeneFamilyGrowth hormone family

GH1 GH2

3.09e-0468321175
GeneFamilyLa ribonucleoprotein domain containing|RNA binding motif containing

LARP4 LARP4B

4.31e-047832625
GeneFamilyAF4/FMR2 family|Super elongation complex

ELL2 MLLT1

7.34e-0498321280
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD2 RANBP2 RGPD3

1.94e-03115834769
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZEB1 TSHZ2

2.10e-0315832529
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RASGRF2 ARHGEF5 PLEKHG1

3.47e-0366833722
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

FOXO3 RANBP2 ZEB1 CDC42BPA ZFYVE16 NUP98 DYRK1A LARP4 MAP3K4 NEDD4 LARP4B PPP2R3A ELL2 DLC1 TLE4 KIF14 AGAP1

7.71e-0785612617M4500
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

FOXO3 CDC42BPA NUP98 DYRK1A LARP4 NEDD4 LARP4B PPP2R3A DLC1 TLE4 KIF14 AGAP1

2.70e-0646612612M13522
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD4 RGPD2 RANBP2 RGPD3

1.87e-05331264MM477
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TSHZ2 ARHGEF5 MRM1 RAP1GAP2 ITGB1 PYHIN1 MKI67 SKA3

4.29e-08175128816c835e62a3321f6cf6163954889946bbb869498
ToppCelldroplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF MCPH1 RASGRF2 DYRK1A RAP1GAP2 MAP2K6 NOL8 BAHCC1

4.89e-08178128809d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF TMC7 RASGRF2 INPP5D IRAK2 SPECC1 PLEKHG1

8.77e-08192128856b021c297a21dff357531f21e2464f85186106d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF TMC7 RASGRF2 INPP5D IRAK2 SPECC1 PLEKHG1

9.89e-0819512886bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6L RAP1GAP2 ARHGAP39 MKI67 TREM1 INSYN2B XKR5

4.16e-0716012872020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6L RAP1GAP2 ARHGAP39 MKI67 TREM1 INSYN2B XKR5

4.16e-071601287af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 TMC7 RASGRF2 INPP5D IRAK2 SPECC1 PLEKHG1

5.33e-0716612878e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZEB1 VWF RASGRF2 SPECC1 PLEKHG1 DLC1 PDZD2

9.88e-071821287e67f3234165199085c793915ebb1f9bbd845e933
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZFYVE16 IRAK2 POGZ ELL2 TREM1 TNFAIP3

1.26e-061191286e6f1b9f29dc8fe6b6132c7885234c385159da393
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASH1L LARP4 SPECC1 ITGB1 NEDD4 ZNF106 GOLGB1

1.36e-06191128760c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASH1L LARP4 SPECC1 ITGB1 NEDD4 ZNF106 GOLGB1

1.36e-061911287973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FOXO3 HECTD4 SPECC1 RSC1A1 ELL2 RNF10 KDM7A

1.46e-061931287be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RANBP2 DOCK8-AS1 INPP5D IRAK2 CDH23 SSPOP ELL2

1.68e-061971287b597c292fc1cb381a4325fed15a32966c38def28
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 TMC7 RASGRF2 INPP5D IRAK2 NEDD4 PLEKHG1

1.73e-061981287b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWF TMC7 RASGRF2 IRAK2 SPECC1 PLEKHG1

5.61e-061541286e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

GPHN FAM53A PYHIN1 KIR2DL4 NOL8 PDZD2

8.62e-061661286f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5 CDH23 SPECC1 MKI67 KIF14 SKA3

1.02e-051711286913bae728b5e653771a27c79a309eb023699f1d0
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5 CDH23 SPECC1 MKI67 KIF14 SKA3

1.02e-051711286f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 SPECC1 DLC1 MKI67 SKA3 XKR5

1.02e-051711286b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 SPECC1 DLC1 MKI67 SKA3 XKR5

1.02e-051711286b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellRSV-Healthy-2|Healthy / Virus stimulation, Condition and Cluster

RAP1GAP2 PPM1G MKI67 CEP295 SKA3 MAP2K6

1.16e-051751286c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZEB1 STXBP5 RAP1GAP2 MAST1 AGAP1 PDZD2

1.16e-051751286cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellRSV-Healthy-2|RSV / Virus stimulation, Condition and Cluster

RAP1GAP2 PPM1G MKI67 CEP295 SKA3 MAP2K6

1.16e-0517512860e97189585b7afaf3bd622c3ef10c86412393829
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RGPD2 ZEB1 TSHZ2 SNAP47 PPM1G UHRF2

1.20e-051761286856a8c4211ea33d926b18d8959a03909562aa563
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZEB1 VWF CDC42BPA RASGRF2 PLEKHG1 PDZD2

1.32e-0517912862a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellwk_20-22-Hematologic-Meg-ery-Definitive_erythroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FOXO3 HECTD4 SPECC1 RSC1A1 ELL2 RNF10

1.45e-0518212860c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

ZEB1 VWF RASGRF2 IRAK2 PLEKHG1 PDZD2

1.55e-0518412860f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellControl|World / Disease state, Lineage and Cell class

FOXO3 RANBP2 ZFYVE16 IRAK2 CDH23 ELL2

1.80e-051891286fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF TMC7 RASGRF2 SPECC1 PLEKHG1

1.80e-0518912866463890d8dbee4bc198f91628a5f784970de786a
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

VWF RASGRF2 SPECC1 PLEKHG1 DLC1 PDZD2

1.85e-051901286a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF TMC7 RASGRF2 SPECC1 PLEKHG1

1.91e-051911286b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGPD2 RANBP2 ZEB1 NUP98 ELL2 GOLGB1

1.91e-0519112861ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZEB1 KCNH7 VWF NEDD4 PLEKHG1 DLC1

1.91e-051911286a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASH1L LARP4 SPECC1 ITGB1 NEDD4 ZNF106

1.91e-05191128609db184cb90fe282a14474d7217068c58092c6f8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWF TMC7 RASGRF2 IRAK2 PLEKHG1 TNFAIP3

1.97e-0519212863259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF TMC7 RASGRF2 INPP5D PLEKHG1

1.97e-05192128628eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN FOXO3 TBC1D5 NUP98 ARMC9 ELL2

2.03e-051931286779276e775cb2492e8dd36436295a536084a6415
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF RASGRF2 INPP5D NEDD4 PLEKHG1

2.03e-05193128652e918884877b6659cdca0496390e440f73694a9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF RASGRF2 PLEKHG1 DLC1 TNFAIP3

2.15e-051951286818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellIPF-Endothelial-VE_Peribronchial|IPF / Disease state, Lineage and Cell class

ZEB1 VWF RASGRF2 TSHZ2 PLEKHG1 DLC1

2.15e-0519512862c3ad3cb79f11119ac69c413a938d21199145040
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF TMC7 RASGRF2 IRAK2 PLEKHG1

2.15e-051951286d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF CDC42BPA RASGRF2 PLEKHG1 DLC1

2.21e-0519612864cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF RASGRF2 INPP5D PLEKHG1 DLC1

2.21e-051961286ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF CDC42BPA RASGRF2 PLEKHG1 DLC1

2.21e-051961286d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

INPP5D SPECC1 FAM217A PYHIN1 KIR2DL4 PCDH10

2.21e-051961286bbdc92ec2e95ed7d782df0c72d94f9a9d9439bf0
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

INPP5D ITGB1 PPM1G PYHIN1 UHRF2 AGAP1

2.27e-0519712861ca06d6d288cb58a6e8062ebc01831e58ee5be4b
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZEB1 VWF CDC42BPA TSHZ2 NEDD4 PLEKHG1

2.27e-051971286ebf9be068eaa658493fa7884fd19f34642922acb
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF RASGRF2 INPP5D NEDD4 PLEKHG1

2.34e-051981286953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

GPHN TBC1D5 DYRK1A NHSL1 AGAP1 PDZD2

2.34e-0519812861996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF RASGRF2 INPP5D PLEKHG1 DLC1

2.34e-0519812860a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ZEB1 VWF RASGRF2 INPP5D NEDD4 PLEKHG1

2.34e-0519812868e45551224fbb30c0658ad47dd98335ecf165437
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF CDC42BPA RASGRF2 PLEKHG1 DLC1 PDZD2

2.47e-052001286032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF CDC42BPA RASGRF2 PLEKHG1 DLC1 PDZD2

2.47e-05200128668fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF CDC42BPA RASGRF2 PLEKHG1 DLC1 PDZD2

2.47e-052001286376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF CDC42BPA RASGRF2 PLEKHG1 DLC1 PDZD2

2.47e-0520012867fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Stem_cells|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ZEB1 ERCC6L CEP76 TLE4 KIF14 SKA3

2.47e-0520012860bba93f1271dac704dddcdea8cb0f84a7ac6f42a
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF CDC42BPA RASGRF2 PLEKHG1 DLC1 PDZD2

2.47e-052001286878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

VWF CDC42BPA RASGRF2 PLEKHG1 DLC1 PDZD2

2.47e-0520012867136936d05ab344a560cf159684c881063b5430d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Stem_cells-Neuroepithelial_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ZEB1 ERCC6L CEP76 TLE4 KIF14 SKA3

2.47e-052001286c9479452ab8c51139522383f745f02171ebbd7e2
ToppCellnormal_Lung-T/NK_cells-Naive_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

CATSPERE MRM1 PLEKHG4B UMODL1 MAST1

7.33e-051501285b81f8dfc7755252c457e38bb32b103af3b6f1c01
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CATSPERE TMC7 ITGB1 KCTD3 PCDH10

8.05e-051531285764fb5e5fa028c137b8ea65dcd5e4ec9b22191e9
ToppCellCD8+_Memory_T_cell-RSV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

NPR2 PCNX3 MRM1 ZNF395 SPECC1

9.37e-0515812855ae737757a49fc96bde1e57e02066f9f65654ea1
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAP1GAP2 ARHGAP39 MKI67 TREM1 INSYN2B

9.37e-051581285121d63b8e2e37107467b170e5b2c798a7dbf6325
ToppCellfacs-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAP1GAP2 ARHGAP39 MKI67 TREM1 INSYN2B

9.94e-051601285bc4a93dc5f37829799c37877e751ff3bc122e4ab
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 SPECC1 DLC1 TLE2 MUC2

1.05e-0416212855f009b231f21861afee9cc0c569082e1135f929c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGPD2 ZEB1 TSHZ2 ELL2 TLE2

1.05e-04162128580317c4253bf8e897782e562f29835f181c65b98
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TSHZ2 SPECC1 DLC1 TLE2 MUC2

1.05e-041621285b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DOCK8-AS1 ARHGAP39 MAGEE1 LIG3 ZNF592

1.05e-041621285ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCellCOVID-CD8-memory_CD4|COVID / Condition, Cell_class and T cell subcluster

NPR2 ZEB1 CDH23 MAGEE1 AGAP1

1.05e-04162128522b2a32217d357146c117e618813d451510a1801
ToppCellAdult-Immune-dendritic_cell|Adult / Lineage, Cell type, age group and donor

ZEB1 INPP5D TEX15 SPECC1 SLCO5A1

1.15e-041651285073f52698dac1fe4edd7410865f81b30e1c7196a
ToppCellDividing_Macrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ERCC6L MKI67 MAST1 KIF14 SKA3

1.18e-041661285c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCell10x5'-Liver-Hematopoietic_progenitors|Liver / Manually curated celltypes from each tissue

ERCC6L MKI67 KIF14 SKA3 BAHCC1

1.18e-041661285ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|Liver / Manually curated celltypes from each tissue

ERCC6L MKI67 KIF14 SKA3 BAHCC1

1.18e-041661285a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCellCV-Mild-3|Mild / Virus stimulation, Condition and Cluster

ERCC6L TSHZ2 PPP2R3A IFI30 MAST1

1.18e-0416612855599f90fc0e15a3670b03187085eba91228390a2
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERCC6L MKI67 KIF14 SKA3 XKR5

1.28e-041691285e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERCC6L CEP76 SPATA2 MKI67 SKA3

1.28e-041691285dbf9b1d52b29bf4b60bd23012cc1ea82d344747f
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ERCC6L IL18BP MKI67 KIF14 SKA3

1.36e-041711285e3cab55f39879e2bd3e8bda91802181075839bc4
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ERCC6L IL18BP MKI67 KIF14 SKA3

1.36e-04171128552fdc2a4ec36fb91583b1215362548ceb6740ae1
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERCC6L NUP98 MKI67 KIF14 SKA3

1.39e-0417212851171e754fd503a0c1152162fcc12a115088a08c7
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP76 SLCO5A1 KIF14 XKR5 NOL8

1.43e-0417312858bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEP76 SLCO5A1 KIF14 XKR5 NOL8

1.43e-0417312853e3c61468e703330788a10d850ef41a85680f86d
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PRICKLE4 VWF VSIG2 ERCC6L

1.44e-04921284ed282f0f3da1593bdec5a2b20af5b8f058574167
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PRICKLE4 VWF VSIG2 ERCC6L

1.44e-04921284c5f30d58f235f7a72dfe63f58999c4680502576f
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PRICKLE4 VWF VSIG2 ERCC6L

1.44e-0492128427072dbf6819dca41e41267dc250abfaaf175b2f
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP39 SPATA2 MKI67 KIF14 SKA3

1.47e-04174128572df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGAP39 SPATA2 MKI67 KIF14 SKA3

1.47e-041741285c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERCC6L MKI67 KIF14 SKA3 XKR5

1.47e-041741285dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL18BP SSPOP SLCO5A1 NHSL1 BAHCC1

1.51e-0417512851b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERCC6L PHF24 PLEKHG4B MKI67 SKA3

1.51e-041751285f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCelldroplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERCC6L MKI67 KIF14 SKA3 XKR5

1.51e-04175128573f25bd54309aed1480ddc44bdab518b17e71f92
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4|Striatum / BrainAtlas - Mouse McCarroll V32

ERCC6L MKI67 KIF14 SKA3 XKR5

1.55e-041761285d70fdc7bc48719776ed1e7c01118385e3a21623f
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5-P5_1|Striatum / BrainAtlas - Mouse McCarroll V32

ERCC6L MKI67 KIF14 SKA3 XKR5

1.55e-041761285a84361308e5e96f3a30246cd29e109c321ee65bf
ToppCellAdult-Immune-dendritic_cell-D175|Adult / Lineage, Cell type, age group and donor

ZEB1 IRAK2 SPECC1 SLCO5A1 PLEKHG1

1.55e-0417612851f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGPD2 DOCK8-AS1 IL18BP SLCO5A1 IFI30

1.59e-041771285345cebc19f93970a9a46be139208b300081f5493
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERCC6L RGPD3 MKI67 KIF14 SKA3

1.77e-04181128573b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF TSHZ2 IRAK2 PLEKHG1 DLC1

1.81e-041821285fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZEB1 VWF TSHZ2 SPECC1 DLC1

1.81e-041821285fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellCOVID-19-kidney-Mito-rich_EC|kidney / Disease (COVID-19 only), tissue and cell type

ZEB1 VWF INPP5D PLEKHG1 DLC1

1.86e-0418312853c4153479fc4ab2d073d92cee120480015555914
ToppCellLV-07._Pericyte|World / Chamber and Cluster_Paper

ZEB1 CDC42BPA SPECC1 DLC1 PDZD2

1.86e-041831285273db6a3b00a93ca852498471187b642b5368185
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZEB1 VWF RASGRF2 TSHZ2 PLEKHG1

1.86e-041831285ff95382cfed592190d0636d2b750328471f82e0d
Diseasecortical thickness

FOXO3 NPR2 DCDC1 MCPH1 TBC1D5 SPECC1 NHSL1 PLEKHG1 ZNF106 DLC1 UMODL1 MTHFR KCTD3 ASTN2 AGAP1 PDZD2

1.62e-05111312316EFO_0004840
Diseasemidregional pro atrial natriuretic peptide measurement

C1orf167 MTHFR

1.72e-0521232EFO_0008468
Diseaseneuroimaging measurement

FOXO3 CDC42BPA DCDC1 MCPH1 TBC1D5 ARMC9 DCC LARP4 NHSL1 PLEKHG1 ZNF106 NDEL1 TLE4 AGAP1 BAHCC1

4.01e-05106912315EFO_0004346
Diseaserectum cancer, colonic neoplasm

DYRK1A XKR5

5.16e-0531232EFO_0004288, EFO_1000657
Diseasefactor VIII measurement, Ischemic stroke

VWF STXBP5 HECTD4

6.52e-05191233EFO_0004630, HP_0002140
Diseasecortical surface area measurement

FOXO3 NPR2 DCDC1 MCPH1 PCNX3 TBC1D5 ARHGAP39 STRIP1 NHSL1 PLEKHG1 ZNF106 NDEL1 TLE4 ASTN2 AGAP1 PDZD2

1.52e-04134512316EFO_0010736
DiseaseMalignant neoplasm of breast

ZEB1 CATSPERE VWF RASGRF2 NUP98 MAGEE1 CIC NEDD4 MTHFR MKI67 TREM1 ASTN2 ZNF281 GOLGB1

1.59e-04107412314C0006142
Diseasemucositis (biomarker_via_orthology)

MKI67 MUC2

1.71e-0451232DOID:0080178 (biomarker_via_orthology)
Diseaseisolated growth hormone deficiency type II (implicated_via_orthology)

GH1 GH2

1.71e-0451232DOID:0060872 (implicated_via_orthology)
Diseaseoptic disc size measurement

CDC42BPA DCDC1 STRIP1 DLC1 MAP2K6 PDZD2

2.26e-042051236EFO_0004832
Diseaseaxial length measurement, refractive error

RASGRF2 ASTN2

2.56e-0461232EFO_0005318, MONDO_0004892
Diseaseessential thrombocythemia (is_implicated_in)

MPL VWF

2.56e-0461232DOID:2224 (is_implicated_in)
DiseaseIschemic stroke, von Willebrand factor measurement

VWF STXBP5 HECTD4

2.64e-04301233EFO_0004629, HP_0002140
Diseaseisolated growth hormone deficiency (implicated_via_orthology)

GH1 GH2

3.57e-0471232DOID:0060870 (implicated_via_orthology)
DiseaseCardiovascular Diseases

VWF GH1 MTHFR

4.56e-04361233C0007222
Diseasesphingomyelin 16:1 measurement

FAM53A ASTN2

4.75e-0481232EFO_0010392
DiseaseTinnitus, wellbeing measurement

VSIG2 STXBP5 CDH23 ASTN2

7.10e-04961234EFO_0007869, HP_0000360
Diseasemean arterial pressure, alcohol drinking

HECTD4 ICE1 NHLRC2 PLEKHG1

7.68e-04981234EFO_0004329, EFO_0006340
DiseaseAlcohol Use Disorder

GPHN VWF PPM1G

8.26e-04441233C0001956
DiseaseBarrett's esophagus (is_marker_for)

MKI67 MUC2

9.25e-04111232DOID:9206 (is_marker_for)
DiseaseAlcoholic Intoxication, Chronic

GPHN VWF RASGRF2 GH1 MTHFR PCDH10

9.29e-042681236C0001973
Diseasesystolic blood pressure, alcohol consumption measurement

NHLRC2 PLEKHG1 MTHFR

1.00e-03471233EFO_0006335, EFO_0007878
Diseasepsoriasis

CDSN KCNH7 ZFYVE16 RAP1GAP2 SPATA2 TNFAIP3

1.02e-032731236EFO_0000676
Diseasemean arterial pressure

DCDC1 PCNX3 STXBP5 HECTD4 NHLRC2 PLEKHG1 MTHFR BAHCC1

1.19e-034991238EFO_0006340
Diseasealcohol and nicotine codependence

RGPD2 PLEKHG1

1.30e-03131232EFO_0004776
Diseaseesophageal cancer (is_implicated_in)

DCC TNFAIP3

1.30e-03131232DOID:5041 (is_implicated_in)
Diseasemean arterial pressure, alcohol consumption measurement

NHLRC2 PLEKHG1 MTHFR

1.35e-03521233EFO_0006340, EFO_0007878
Diseasediastolic blood pressure, alcohol consumption measurement

HECTD4 PLEKHG1 MTHFR

1.50e-03541233EFO_0006336, EFO_0007878
Diseasecongenital hypothyroidism (biomarker_via_orthology)

GH1 GH2

1.52e-03141232DOID:0050328 (biomarker_via_orthology)
Diseaseanemia (is_implicated_in)

GH1 MTHFR

1.52e-03141232DOID:2355 (is_implicated_in)
Diseasediastolic blood pressure, alcohol drinking

HECTD4 C1orf167 NHLRC2 PLEKHG1

1.53e-031181234EFO_0004329, EFO_0006336
Diseaseserum gamma-glutamyl transferase measurement

FOXO3 ZEB1 CDC42BPA PCNX3 FAM53A ASH1L HECTD4 DYRK1A PPM1G ASTN2 BAHCC1

1.57e-0391412311EFO_0004532
Diseasecolorectal cancer (is_implicated_in)

DCC DLC1 MKI67 TNFAIP3

1.68e-031211234DOID:9256 (is_implicated_in)
DiseaseLymphoma, Follicular, Grade 2

MTHFR TNFAIP3

1.75e-03151232C1956132
DiseaseLymphoma, Follicular, Grade 3

MTHFR TNFAIP3

1.75e-03151232C1956131
DiseaseLymphoma, Follicular, Grade 1

MTHFR TNFAIP3

1.75e-03151232C1956130
DiseaseIschemic stroke, tissue plasminogen activator measurement

STXBP5 HECTD4

1.75e-03151232EFO_0004791, HP_0002140
DiseaseLymphoma, Large-Cell, Follicular

MTHFR TNFAIP3

1.75e-03151232C0079745
DiseaseLymphoma, Small Cleaved-Cell, Follicular

MTHFR TNFAIP3

1.75e-03151232C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

MTHFR TNFAIP3

1.75e-03151232C0079758
DiseaseLibman-Sacks Disease

PCNX3 PHRF1 TNFAIP3

1.85e-03581233C0242380
DiseaseEndometrial Neoplasms

ZEB1 MAP3K4 MTHFR

1.85e-03581233C0014170
Diseaseprimary autosomal recessive microcephaly (is_implicated_in)

MCPH1 KIF14

1.99e-03161232DOID:0070296 (is_implicated_in)
Diseasesystolic blood pressure, alcohol drinking

HECTD4 C1orf167 NHLRC2 PLEKHG1

2.06e-031281234EFO_0004329, EFO_0006335
Diseasehypertension, white matter hyperintensity measurement

DCC PLEKHG1 ZNF106

2.23e-03621233EFO_0000537, EFO_0005665
Diseasegraft-versus-host disease (is_implicated_in)

MTHFR MKI67

2.25e-03171232DOID:0081267 (is_implicated_in)
Diseasecholangiocarcinoma (is_marker_for)

MKI67 TNFAIP3 MUC2

2.45e-03641233DOID:4947 (is_marker_for)
Diseasetemporal lobe epilepsy (is_marker_for)

FOXO3 DTNBP1

3.12e-03201232DOID:3328 (is_marker_for)
DiseaseLymphoma, Follicular

MTHFR TNFAIP3

3.12e-03201232C0024301
DiseaseLupus Erythematosus, Systemic

PCNX3 PHRF1 TNFAIP3

3.29e-03711233C0024141
DiseaseEndometrial Carcinoma

ZEB1 MAP3K4 MTHFR

3.42e-03721233C0476089
Diseasebipolar disorder, body mass index

TSHZ2 CDH23 PDZD2

3.42e-03721233EFO_0004340, MONDO_0004985
DiseaseNeutropenia

NUP98 MTHFR

3.44e-03211232C0027947
Diseasehepatitis B (is_marker_for)

MPL TREM1

3.44e-03211232DOID:2043 (is_marker_for)
Diseasebrain volume measurement

FOXO3 DCDC1 MRM1 DCC SPECC1 PLEKHG1 ZNF106 ASTN2

3.54e-035951238EFO_0006930
Diseaseattention deficit hyperactivity disorder

RANBP2 TSHZ2 DCC DLC1 KCTD3 ASTN2

3.75e-033541236EFO_0003888
Diseaserenal system measurement, blood urea nitrogen measurement

DCDC1 HECTD4

3.77e-03221232EFO_0004741, EFO_0004742
DiseaseAutosomal Recessive Primary Microcephaly

MCPH1 KIF14

3.77e-03221232C3711387
Diseaseosteoporosis (biomarker_via_orthology)

GH1 GH2

3.77e-03221232DOID:11476 (biomarker_via_orthology)
DiseaseGranulomatous Slack Skin

ZEB1 TNFAIP3

3.77e-03221232C0376407
DiseaseOvarian Serous Adenocarcinoma

MAP3K4 MAST1

4.12e-03231232C1335177
Diseaseobsolete Mendelian syndromes with cleft lip/palate

RASGRF2 MRM1

4.12e-03231232MONDO_0015335
DiseaseLymphoma, T-Cell, Cutaneous

ZEB1 TNFAIP3

4.12e-03231232C0079773
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF STXBP5

4.12e-03231232EFO_0004286, EFO_0004791

Protein segments in the cluster

PeptideGeneStartEntry
STLTALKTPACVPVS

UMODL1

691

Q5DID0
TLACTERPSKNSHPV

TREM1

66

Q9NP99
SSCASVSRNKPDSVP

nan

126

Q6ZR03
SSCRRTKKVSSEAPP

BAHCC1

2051

Q9P281
ATSSCTKTPSALEPL

C1orf167

831

Q5SNV9
SQRPSESTNCSPTRK

ASH1L

1671

Q9NR48
PVCSSRDAVSSPQKR

ELL2

306

O00472
PRATSACAPISSPKT

AGAP1

411

Q9UPQ3
NKSSPTTELRCSSPG

CATSPERE

61

Q5SY80
TSCAARAPETASAPL

ARHGEF5

546

Q12774
RPLSSTSNPFKSSKC

SPECC1

341

Q5M775
PSCDKTPLSTLAIVA

NPR2

446

P20594
SGLSFSQPSCKTRVP

CCNT1

621

O60563
FPPLCASTIDASVTS

CEP76

511

Q8TAP6
ETSACKPSSVRLAPS

DYRK1A

6

Q13627
GTFSDPCKDPTRITS

CDSN

36

Q15517
AAKACPSTPESREKT

C2orf73

246

Q8N5S3
TDCGRPPLKATSSAT

CDH23

861

Q9H251
SPCRLKTVTVSTLPA

ASTN2

61

O75129
SSTPRESPCGKIAVA

RANBP2

2456

P49792
SRKPSLCQATSATPT

ARHGAP39

496

Q9C0H5
ISTTPAKLRNPCTSE

ITGB1

196

P05556
TSRLSTASCPTPKVQ

GPHN

276

Q9NQX3
SLSPSKRACASPSAQ

LRWD1

241

Q9UFC0
TCSLTPRVPFKLVST

PCDHA7

386

Q9UN72
SSSEEAPSRTIPTAC

DCC

1321

P43146
CSISASKRNRPVSAP

DCDC1

126

M0R2J8
SSPAVSSEECTPSRI

KIF14

1631

Q15058
SKDSSRCSTPGLDPE

MTHFR

26

P42898
LPSKADTSQEICSPR

NUP98

1016

P52948
ICSPRLPISASHSSK

NUP98

1026

P52948
SEIPIKRECPTSTST

KDM7A

716

Q6ZMT4
SVDRNPSKCSLVLPS

MAGEE1

421

Q9HCI5
PSSPAQLSCRSLSKK

MCPH1

436

Q8NEM0
TRPTSPTSLCTLLSK

NEDD4

276

P46934
DIPSSTASLCSRKTG

IRAK2

431

O43187
SIKTDRSFSPSSQCP

KCNH7

1096

Q9NS40
TASVRSTKDPCPSQP

IL18BP

41

O95998
QRHFITSSSSKPCEP

LRRC53

521

A6NM62
REGKPSTPESCVSSS

ARMC9

696

Q7Z3E5
SREPSVPASCAVSAT

LARP4B

581

Q92615
ESPSSCSPSKNRRAQ

NHSL1

1466

Q5SYE7
TVFRKVSSTPPVRCS

PCNX3

121

Q9H6A9
CPHSSSTTKRPAVTV

MUC2

4661

Q02817
SQPASPRVTKCKARS

PDZD2

1266

O15018
LRAKPPSSSSTCTDS

DTNBP1

291

Q96EV8
ASKISSRDSKPPCRS

PHRF1

646

Q9P1Y6
PELTDTATSTKRCPK

MKI67

2591

P46013
RKTPACISELPTSSG

PRR25

81

Q96S07
KRTCDSITPSKSSPV

NOL8

256

Q76FK4
FLKPCSPSRSTDTEH

PCDH10

836

Q9P2E7
SSPTPKRSLSSSKCD

LIG3

241

P49916
TRSISGTPAETPACK

HECTD4

1071

Q9Y4D8
SSPIEKVSPSCLTRI

PPP2R3A

561

Q06190
KSAPSIRLSPVTACA

NHLRC2

596

Q8NBF2
SLAPAKCSAPSSAVT

MAST1

1511

Q9Y2H9
PSQRSKRPSTDTSVC

KIR2DL4

316

Q99706
IRDPKDTPFSTCSSS

PRICKLE4

291

Q2TBC4
SSTPRESPCGKIAVA

RGPD3

1481

A6NKT7
SRCVPEKPAKAITSS

ICE1

226

Q9Y2F5
STPTDCSPDTLSKIR

ICE1

1611

Q9Y2F5
RSSSKSSHCDSPPRS

BNIP3

56

Q12983
VCRSALETSAFPPSK

DOCK8-AS1

176

Q5T8R8
GKKPDVCPSSTSSLR

IFI30

231

P13284
TPACTPSNRLTAKGA

PYHIN1

116

Q6K0P9
GAEASPSPCITERSK

ARL6IP4

51

Q66PJ3
STTKPSRASTASPCN

LARP4

586

Q71RC2
SSSKRPCSATISYRP

KRTAP16-1

381

A8MUX0
PNSKVSGRRSPESCS

MLLT1

466

Q03111
TFCTPAVTERPSSSK

FAM217A

311

Q8IXS0
KGRCPSVSAPSLITD

CEP295

611

Q9C0D2
RSVSASVCPIKPSDS

RSC1A1

31

Q92681
LSTSRCATPNISPAT

KCTD3

601

Q9Y597
SSTKSAICARAIPAS

ERCC6L

236

Q2NKX8
SSTPPRDLDSKACIS

MAP2K6

26

P52564
SRTPPSSEEKCSAVS

MAP3K4

586

Q9Y6R4
APRTTSCEKLTAAPS

MIDN

346

Q504T8
SASLSPSVSKPCTVE

FOXO3

351

O43524
SSTPRESPCGKIAVA

RGPD4

1481

Q7Z3J3
SDHLSVRPSCPSKQS

SPHKAP

1171

Q2M3C7
VRPSCPSKQSSTESI

SPHKAP

1176

Q2M3C7
SSGCTSKTLAVPPEA

RIN1

636

Q13671
RARCDSTSSTPKTPD

RAP1GAP2

581

Q684P5
TAKAAALSTKTPAPC

SPAG8

66

Q99932
QSLRSRSCSSPPSKN

SSPOP

4026

A2VEC9
LRSARTSSPAEKSCS

SNAP47

356

Q5SQN1
SRSSTPRESPCGKIA

RGPD2

1471

P0DJD1
AADTTELSPCRSPST

RASGRF2

841

O14827
SCPLTPVVSKSSAGA

MRM1

181

Q6IN84
SSTLPAVVPAGCSSK

POGZ

1246

Q7Z3K3
EAGPSCSSASDKLPR

PPM1G

236

O15355
KSLPVLSSASCRPSL

SLCO5A1

36

Q9H2Y9
SAACSSAVRKPAISL

STRIP1

196

Q5VSL9
KQVPAPRLRSFTCSS

INPP5D

1076

Q92835
TVSASPCSAPLARAS

SKIV2L

241

Q15477
ETFTRKTDSSPSPCL

STXBP5

801

Q5T5C0
PSCTPASKGRRTVDS

CDC42BPA

971

Q5VT25
KRFPEAPSCSVSISH

PHF24

326

Q9UPV7
PSPVTRTRSLSACNK

DLC1

756

Q96QB1
TPIKITASPDRCFSA

ACTRT1

326

Q8TDG2
RRSSCSSEPNTPKSA

CIC

1416

Q96RK0
TSLCFSESIPTPSNR

GH2

76

P01242
PPVASSCISEKSPRS

SKA3

141

Q8IX90
SCISEKSPRSPQLSD

SKA3

146

Q8IX90
TTKRPISDDDCPSAS

UHRF2

661

Q96PU4
PCTTAPKIAASSSFR

SH3GL1

276

Q99961
RSPPAKESALSKCQS

SPATA2

371

Q9UM82
LHSKSKPSTTPTSRC

SPATA2

446

Q9UM82
CADTRKVPLDSSPAT

VWF

1031

P04275
LSTSLPPSCHQRSKS

TNFAIP3

551

P21580
TPRIKAELTSSAPAC

TLE4

566

Q04727
SACSSEPTQTLASRP

PLEKHG4B

701

Q96PX9
PITKSGFTRLSSSPC

RNF10

491

Q8N5U6
KSIKPSDSPRSICSD

ZNF592

341

Q92610
AAAPSAACSLSPVRS

ZNF395

431

Q9H8N7
SDVSEPCSTRVKTPT

ZNF281

876

Q9Y2X9
TSLCFSESIPTPSNR

GH1

76

P01241
TAALSPPKATVSDTC

MPL

546

P40238
LGKATEPLRSPSCSS

TSHZ2

706

Q9NRE2
RPRTGLKTSQCSSPS

ZEB1

301

P37275
TTSQCKSEPPLLRTS

UCKL1

61

Q9NWZ5
TKSTPRQLSAACSVP

PLEKHG1

1116

Q9ULL1
YISSASSPVPSKRTC

ZMYM1

121

Q5SVZ6
LRSTSGKSQAPVCSP

TBC1D5

741

Q92609
VPSSCDSLKRNHLTP

TEX15

2371

Q9BXT5
LSTCSSSQPPGDRRK

nan

21

Q5VSD8
LRTAHEPCLTSTPKS

XKR5

651

Q6UX68
STALRCSSSEGAPKP

VSIG2

161

Q96IQ7
TPRIKAELTSSAPAC

TLE2

536

Q04725
ILKTSRELSTSPCNP

ZNF106

631

Q9H2Y7
VSSKDVPSSLSCLPA

ZFYVE16

366

Q7Z3T8
SISRIPSSKACGPFT

TMC7

621

Q7Z402
SSTAPPTKRHCRSLS

FAM53A

111

Q6NSI3
PVKTVLSSPCDSRGL

FAM53A

316

Q6NSI3
STRPTCSESVPSAKS

GOLGB1

1806

Q14789
QSKETCVPSSPRTHS

INSYN2B

296

A6NMK8
VDKGPSTISSITCSP

NACA

381

E9PAV3
HTSALAPVASSPKEC

NACA

756

E9PAV3
SLKDSPTSPASVTCK

NACA

1646

E9PAV3
TRKSAPSSPTLDCEK

NDEL1

191

Q9GZM8