Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

6.90e-06311755GO:0008327
GeneOntologyMolecularFunctionaminoacyltransferase activity

UBR2 RNF166 MKRN2 COP1 G2E3 ATE1 TRIM3 RNF157 FBXL5 MALT1 MARCHF5 TRIM8 BTRC MGRN1

2.58e-0453217514GO:0016755
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

UBR2 RNF166 MKRN2 COP1 G2E3 TRIM3 RNF157 FBXL5 MALT1 MARCHF5 TRIM8 BTRC MGRN1

2.84e-0447317513GO:0004842
GeneOntologyMolecularFunctionvitamin E binding

AFM NPC1L1

4.53e-0441752GO:0008431
GeneOntologyMolecularFunctionubiquitin protein ligase activity

UBR2 RNF166 MKRN2 COP1 G2E3 TRIM3 RNF157 MARCHF5 TRIM8 BTRC MGRN1

4.56e-0437217511GO:0061630
GeneOntologyBiologicalProcessprotein polyubiquitination

UBR2 RNF166 KBTBD6 MKRN2 TTC36 G2E3 KBTBD7 TRIM3 MARCHF5 TRIM8 TNKS2 BTRC MGRN1

1.12e-0628917413GO:0000209
GeneOntologyBiologicalProcessnegative regulation of Ras protein signal transduction

EPHB2 TGFB2 RASA4 MFN2 RASA4B

3.39e-06281745GO:0046580
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

EPHB2 GPR4 CDC42BPA KBTBD6 ARHGEF5 IQSEC2 KBTBD7 TGFB2 RASA4 IQSEC1 MFN2 RASA4B NOTCH2

5.30e-0633317413GO:0051056
GeneOntologyBiologicalProcessregulation of Ras protein signal transduction

EPHB2 TGFB2 RASA4 MFN2 RASA4B NOTCH2

1.25e-05611746GO:0046578
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

3.36e-05441745GO:0006346
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

EPHB2 GPR4 RALGDS CDC42BPA KBTBD6 ARHGEF5 IQSEC2 KBTBD7 TGFB2 RASA4 AGTR1 IQSEC1 MFN2 RASA4B NOTCH2

5.38e-0553817415GO:0007264
GeneOntologyBiologicalProcessheterochromatin formation

UBR2 MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B MOV10L1 UTY

7.47e-051631748GO:0031507
GeneOntologyBiologicalProcessreceptor-mediated endocytosis involved in cholesterol transport

ABCA2 LDLR PCSK9

9.26e-05111743GO:0090118
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

9.97e-05551745GO:0140718
GeneOntologyBiologicalProcessRas protein signal transduction

EPHB2 RALGDS TGFB2 RASA4 MFN2 RASA4B NOTCH2

1.08e-041281747GO:0007265
GeneOntologyCellularComponentPCSK9-LDLR complex

LDLR PCSK9

6.97e-0521752GO:1990666
GeneOntologyCellularComponentCOPII vesicle coat

SEC24C SEC23B SEC23A

2.98e-04161753GO:0030127
GeneOntologyCellularComponentextracellular matrix

VWF ZAN LAMB1 MUC5B TECTA SVEP1 TGFB2 FBN1 EFEMP1 HMCN2 OTOGL ADAMTS18 LOXL4 ALB FBN3

4.27e-0465617515GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

VWF ZAN LAMB1 MUC5B TECTA SVEP1 TGFB2 FBN1 EFEMP1 HMCN2 OTOGL ADAMTS18 LOXL4 ALB FBN3

4.41e-0465817515GO:0030312
GeneOntologyCellularComponentbasement membrane

LAMB1 TGFB2 FBN1 EFEMP1 HMCN2 ALB

5.73e-041221756GO:0005604
GeneOntologyCellularComponentendolysosome membrane

TLR7 LDLR PCSK9

5.92e-04201753GO:0036020
GeneOntologyCellularComponentconnexin complex

GJD2 GJA9 GJA10

7.90e-04221753GO:0005922
HumanPhenoPerifollicular hyperkeratosis

KRT81 KRT83 KRT86

9.43e-064693HP:0007468
HumanPhenoAbnormal mitral valve physiology

ERAP1 SPEG TLR7 AIP ADNP LDLR FBN1 MTX2 ALDH18A1 NOTCH2 PCSK9

2.41e-051806911HP:0031481
HumanPhenoAbnormal mitral valve morphology

VWF ERAP1 SPEG TLR7 AIP ADNP LDLR TGFB2 FBN1 MTX2 ALDH18A1 NOTCH2 PCSK9

3.09e-052576913HP:0001633
HumanPhenoAbnormal perifollicular morphology

KRT81 KRT83 KRT86

4.62e-056693HP:0031285
HumanPhenoAbnormal atrioventricular valve morphology

VWF ERAP1 SPEG TLR7 AIP ADNP LDLR NR2F2 TGFB2 FBN1 MTX2 SEC24C ALDH18A1 NOTCH2 PCSK9

4.93e-053506915HP:0006705
HumanPhenoMitral regurgitation

ERAP1 SPEG TLR7 AIP ADNP LDLR FBN1 MTX2 ALDH18A1 PCSK9

5.69e-051636910HP:0001653
HumanPhenoAbnormal atrioventricular valve physiology

ERAP1 SPEG TLR7 AIP ADNP LDLR FBN1 MTX2 ALDH18A1 NOTCH2 PCSK9

1.23e-042156911HP:0031650
HumanPhenoDeformed sella turcica

SLC17A5 MTX2 ALDH18A1 NOTCH2

1.27e-0420694HP:0002681
DomainGrowth_fac_rcpt_

EPHB2 TMEM67 KRT83 LAMB1 LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

1.41e-1115617115IPR009030
DomainEGF_Ca-bd_CS

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

8.55e-119717112IPR018097
DomainEGF_CA

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

1.09e-109917112PS01187
DomainEGF-type_Asp/Asn_hydroxyl_site

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

2.46e-1010617112IPR000152
DomainEGF_CA

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 LRP2 ADGRE5 FBN3 NOTCH2

3.71e-108617111PF07645
DomainEGF-like_dom

TPO ZAN ADAM15 LAMB1 TECTA LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

1.21e-0924917116IPR000742
DomainEGF_CA

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

1.28e-0912217112SM00179
DomainEGF-like_Ca-bd_dom

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

1.54e-0912417112IPR001881
DomainASX_HYDROXYL

TPO LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 LRP2 ADGRE5 FBN3 NOTCH2

1.92e-0910017111PS00010
DomainEGF

TPO ZAN ADAM15 LAMB1 TECTA LDLR SVEP1 THBD FBN1 EFEMP1 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

4.48e-0923517115SM00181
DomainEGF_2

EPHB2 TPO ZAN ADAM15 LAMB1 LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 FBN3 NOTCH2

2.26e-0826517115PS01186
DomainEGF_3

TPO ZAN ADAM15 LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 ADGRE5 FBN3 NOTCH2

3.58e-0823517114PS50026
DomainEGF_1

TPO ZAN ADAM15 LAMB1 LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 FBN3 NOTCH2

9.90e-0825517114PS00022
DomainTIL_dom

VWF ZAN MUC5B TECTA LRP2

1.14e-07141715IPR002919
DomainEGF-like_CS

TPO ZAN ADAM15 LAMB1 LDLR SVEP1 THBD FBN1 EFEMP1 HMCN2 SLIT3 LRP2 FBN3 NOTCH2

1.32e-0726117114IPR013032
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L2 MBD3L3 MBD3L4

2.32e-0771714IPR025884
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L2 MBD3L3 MBD3L4

2.32e-0771714IPR032343
DomainMBDa

MBD3L5 MBD3L2 MBD3L3 MBD3L4

2.32e-0771714PF16564
DomainMBD_C

MBD3L5 MBD3L2 MBD3L3 MBD3L4

2.32e-0771714PF14048
DomainC8

VWF ZAN MUC5B TECTA

3.17e-06121714PF08742
DomainTIL

VWF ZAN MUC5B TECTA

3.17e-06121714PF01826
DomaincEGF

THBD FBN1 EFEMP1 LRP2 FBN3

3.42e-06261715PF12662
DomaincEGF

THBD FBN1 EFEMP1 LRP2 FBN3

3.42e-06261715IPR026823
DomainVWF_A

ITGA11 VWF SVEP1 ANTXRL HMCN2 SEC24C SEC23B SEC23A

3.53e-06991718IPR002035
DomainUnchr_dom_Cys-rich

VWF ZAN MUC5B TECTA

4.55e-06131714IPR014853
DomainC8

VWF ZAN MUC5B TECTA

4.55e-06131714SM00832
DomainVWF_type-D

VWF ZAN MUC5B TECTA

1.13e-05161714IPR001846
DomainVWFD

VWF ZAN MUC5B TECTA

1.13e-05161714PS51233
DomainVWD

VWF ZAN MUC5B TECTA

1.13e-05161714SM00216
DomainVWD

VWF ZAN MUC5B TECTA

1.13e-05161714PF00094
DomainSec23/24_helical_dom

SEC24C SEC23B SEC23A

1.48e-0561713IPR006900
DomainSec23_24_beta_S

SEC24C SEC23B SEC23A

1.48e-0561713IPR012990
Domainzf-Sec23_Sec24

SEC24C SEC23B SEC23A

1.48e-0561713PF04810
DomainSec23_trunk

SEC24C SEC23B SEC23A

1.48e-0561713PF04811
DomainSec23_helical

SEC24C SEC23B SEC23A

1.48e-0561713PF04815
DomainSec23_BS

SEC24C SEC23B SEC23A

1.48e-0561713PF08033
DomainSec23/24_trunk_dom

SEC24C SEC23B SEC23A

1.48e-0561713IPR006896
DomainZnf_Sec23_Sec24

SEC24C SEC23B SEC23A

1.48e-0561713IPR006895
Domain-

UBR2 ZMYND11 RNF166 MKRN2 ZNF521 COP1 DIDO1 G2E3 TRIM3 RNF157 ZFPL1 MARCHF5 TRIM8 ZFYVE26 MGRN1

1.70e-05449171153.30.40.10
DomainEGF

ZAN TECTA SVEP1 THBD SLIT3 LRP2 FBN3 NOTCH2

2.10e-051261718PF00008
DomainZnf_RING/FYVE/PHD

UBR2 ZMYND11 RNF166 MKRN2 ZNF521 COP1 DIDO1 G2E3 TRIM3 RNF157 ZFPL1 MARCHF5 TRIM8 ZFYVE26 MGRN1

2.20e-0545917115IPR013083
DomainVWC_out

VWF ZAN MUC5B TECTA

2.36e-05191714SM00215
DomainVWFC_2

VWF ZAN MUC5B TECTA CHRD

2.38e-05381715PS50184
DomainVWC

VWF ZAN MUC5B TECTA CHRD

2.38e-05381715SM00214
DomainVWF_dom

VWF ZAN MUC5B TECTA CHRD

3.92e-05421715IPR001007
DomainZnf_RING

UBR2 ZMYND11 RNF166 MKRN2 COP1 G2E3 TRIM3 RNF157 ZFPL1 MARCHF5 TRIM8 MGRN1

4.83e-0532617112IPR001841
Domain-

VWF SVEP1 ANTXRL SEC24C SEC23B SEC23A

5.97e-057417163.40.50.410
DomainEphrin_rec_like

EPHB2 SVEP1 TG

1.18e-04111713PF07699
DomainRING

UBR2 ZMYND11 RNF166 MKRN2 COP1 G2E3 TRIM3 RNF157 ZFPL1 TRIM8 MGRN1

1.20e-0430517111SM00184
DomainTILa_dom

ZAN TECTA

2.49e-0431712IPR025615
DomainSerum_albumin/AFP/Afamin

AFM ALB

2.49e-0431712IPR021177
DomainTILa

ZAN TECTA

2.49e-0431712PF12714
Domain-

RASA4 RASA4B

2.49e-04317124.10.1130.10
DomainIQSEC_PH

IQSEC2 IQSEC1

2.49e-0431712IPR033742
DomainIQ_SEC7_PH

IQSEC2 IQSEC1

2.49e-0431712PF16453
DomainFBN

FBN1 FBN3

2.49e-0431712IPR011398
DomainGelsolin

SEC24C SEC23B SEC23A

2.55e-04141713PF00626
DomainGelsolin-like_dom

SEC24C SEC23B SEC23A

2.55e-04141713IPR007123
DomainVWFC_1

VWF ZAN MUC5B CHRD

3.18e-04361714PS01208
DomainALBUMIN

AFM ALB

4.94e-0441712SM00103
DomainSerum_albumin_N

AFM ALB

4.94e-0441712IPR014760
DomainSerum_albumin_CS

AFM ALB

4.94e-0441712IPR020857
DomainALBUMIN_2

AFM ALB

4.94e-0441712PS51438
DomainALBUMIN_1

AFM ALB

4.94e-0441712PS00212
DomainSerum_albumin

AFM ALB

4.94e-0441712PF00273
DomainCTCK_1

VWF MUC5B SLIT3

5.56e-04181713PS01185
DomainCONNEXINS_1

GJD2 GJA9 GJA10

6.56e-04191713PS00407
DomainConnexin

GJD2 GJA9 GJA10

7.67e-04201713IPR000500
DomainConnexin_CCC

GJD2 GJA9 GJA10

7.67e-04201713IPR019570
DomainConnexin_N

GJD2 GJA9 GJA10

7.67e-04201713IPR013092
DomainConnexin_CCC

GJD2 GJA9 GJA10

7.67e-04201713SM01089
DomainCONNEXINS_2

GJD2 GJA9 GJA10

7.67e-04201713PS00408
DomainConnexin

GJD2 GJA9 GJA10

7.67e-04201713PF00029
DomainConnexin_CS

GJD2 GJA9 GJA10

7.67e-04201713IPR017990
DomainCNX

GJD2 GJA9 GJA10

7.67e-04201713SM00037
DomainMusac_Ach_rcpt

CHRM2 CHRM5

8.18e-0451712IPR000995
DomainSerum_albumin-like

AFM ALB

8.18e-0451712IPR020858
DomainHnRNP-L/PTB

PTBP2 PTBP1

8.18e-0451712IPR006536
DomainVWFA

ITGA11 VWF SVEP1 ANTXRL HMCN2

9.38e-04821715PS50234
DomainCT

VWF MUC5B SLIT3

1.02e-03221713SM00041
DomainVWA

ITGA11 VWF SVEP1 ANTXRL HMCN2

1.05e-03841715SM00327
Domainzf-C3HC4

RNF166 MKRN2 COP1 TRIM3 RNF157 MARCHF5 TRIM8 MGRN1

1.06e-032231718PF00097
DomainPH

CDC42BPA ARHGEF5 IQSEC2 RASA4 IQSEC1 RASA4B AGAP7P AGAP4 AGAP6

1.08e-032781719SM00233
DomainPH_DOMAIN

CDC42BPA ARHGEF5 IQSEC2 RASA4 IQSEC1 RASA4B AGAP7P AGAP4 AGAP6

1.10e-032791719PS50003
DomainPH_domain

CDC42BPA ARHGEF5 IQSEC2 RASA4 IQSEC1 RASA4B AGAP7P AGAP4 AGAP6

1.13e-032801719IPR001849
DomainALB/AFP/VDB

AFM ALB

1.22e-0361712IPR000264
Domain-

SEC24C SEC23B SEC23A

1.32e-032417133.40.20.10
DomainKeratin_2_head

KRT81 KRT83 KRT86

1.32e-03241713IPR032444
DomainADF-H/Gelsolin-like_dom

SEC24C SEC23B SEC23A

1.32e-03241713IPR029006
DomainKeratin_2_head

KRT81 KRT83 KRT86

1.32e-03241713PF16208
DomainZF_RING_1

UBR2 RNF166 MKRN2 COP1 TRIM3 RNF157 ZFPL1 TRIM8 MGRN1

1.48e-032911719PS00518
DomainEphrin_rec_like

EPHB2 SVEP1 TG

1.50e-03251713SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 SVEP1 TG

1.50e-03251713IPR011641
DomainCys_knot_C

VWF MUC5B SLIT3

1.50e-03251713IPR006207
DomainCTCK_2

VWF MUC5B SLIT3

1.50e-03251713PS01225
DomainKeratin_II

KRT81 KRT83 KRT86

1.68e-03261713IPR003054
DomainTB

FBN1 FBN3

1.70e-0371712PF00683
DomainVWA

ITGA11 VWF SVEP1 ANTXRL

1.72e-03561714PF00092
DomainZF_RING_2

UBR2 RNF166 MKRN2 COP1 TRIM3 RNF157 ZFPL1 TRIM8 MGRN1

1.74e-032981719PS50089
DomainhEGF

SVEP1 FBN3 NOTCH2

2.09e-03281713PF12661
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

1.93e-116177512504854
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

1.93e-116177518942147
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RALGDS ABCA2 CDC42BPA USP28 CECR2 DIDO1 G2E3 ADNP MTA3 SEMA5B HPS4 SLIT3 NCAPD2 HMGXB3 AGAP7P ESPL1 AGAP4 AGAP6 MGRN1

3.55e-115291771914621295
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF821 ABCA2 VWF MCHR1 DIS3L USP28 KRT83 IQSEC2 ZNF521 LAMB1 ABCC5 XPC AIP TARS3 FBN1 EFEMP1 MTA3 HPS4 TRIM8 LRP2 RORB PLAUR IFT122 ANKRD36 TNKS2 BTRC RECK ZNF292

8.94e-1112851772835914814
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

9.30e-0915177515701600
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

EPHB2 UBR2 TMEM67 ITGA11 ABCA2 ERAP1 ADAM15 HS6ST2 LAMB1 AIP LDLR TGFB2 CLPTM1L FBN1 EFEMP1 SEC24C TMPO ADGRE5 PLAUR ALDH3A2 NOTCH2 PCSK9 MGRN1

5.38e-0812011772335696571
Pubmed

Novel KRT83 and KRT86 mutations associated with monilethrix.

KRT81 KRT83 KRT86

1.30e-073177325557232
Pubmed

Structure and site of expression of a murine type II hair keratin.

KRT81 KRT83 KRT86

1.30e-07317731372089
Pubmed

Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.

KRT81 KRT83 KRT86

1.30e-07317731712823
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

CHRM5 AGAP7P AGAP4 AGAP6

1.33e-0710177420664521
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

EPHB2 FNDC3B ZMYND11 IQSEC2 INTS1 XPC PTBP1 LDLR ZFPL1 AAR2 CLPTM1L PELP1 MARCHF5 CCNL1 NCAPD2 TMEM209 IQSEC1 MFN2 TMPO LOXL4 ALDH3A2 NOTCH2

2.36e-0712031772229180619
Pubmed

Expression of connexin genes in the human retina.

GJD2 GJA9 GJA10

5.16e-074177320979653
Pubmed

Keratins of the human hair follicle.

KRT81 KRT83 KRT86

5.16e-074177315797458
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

VWF ADAM15 LAMB1 LDLR SVEP1 TGFB2 FBN1 EFEMP1 SLIT3 PCSK9

6.43e-072481771024006456
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

ABCA2 ERAP1 ADAM15 LAMB1 MUC5B LDLR TGFB2 ALB

2.13e-06164177832409323
Pubmed

A family of mammalian proteins homologous to yeast Sec24p.

SEC24C SEC23B SEC23A

2.56e-066177310329445
Pubmed

Sec24 proteins and sorting at the endoplasmic reticulum.

SEC24C SEC23B SEC23A

2.56e-066177310075675
Pubmed

Integrative predictive model of coronary artery calcification in atherosclerosis.

TPO VWF TLR7 LDLR THBD EFEMP1 AGTR1 SCNN1B PCSK9

2.92e-06229177919948975
Pubmed

Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.

ARHGEF5 RASA4 RASA4B

7.12e-068177310810084
Pubmed

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

AGAP7P AGAP4 AGAP6

1.06e-059177312640130
Pubmed

Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction.

TPO VWF THBD

1.51e-0510177320036902
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ERAP1 IQSEC2 RASA4 PACS2 ZNF292 MGRN1

1.69e-0510517769628581
Pubmed

AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

AGAP7P AGAP4 AGAP6

2.08e-0511177315381706
Pubmed

Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.

PTBP2 PTBP1 ALB BTRC

2.09e-0532177436252997
Pubmed

Patients With LDLR and PCSK9 Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia.

LDLR PCSK9

2.58e-052177233533259
Pubmed

Effect of diet and genotype on the miRNome of mice with altered lipoprotein metabolism.

LDLR PCSK9

2.58e-052177237664585
Pubmed

PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum.

LDLR PCSK9

2.58e-052177224144304
Pubmed

Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas.

LDLR PCSK9

2.58e-052177229396908
Pubmed

Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells.

LDLR PCSK9

2.58e-052177219224862
Pubmed

Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation.

LDLR PCSK9

2.58e-052177223690465
Pubmed

Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-Induced Abdominal Aortic Aneurysms in C57BL/6 Mice-Brief Report.

LDLR PCSK9

2.58e-052177227470509
Pubmed

Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.

LDLR PCSK9

2.58e-052177219222187
Pubmed

New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice.

LDLR PCSK9

2.58e-052177233737240
Pubmed

Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice.

LDLR PLAUR

2.58e-052177226313756
Pubmed

Having excess levels of PCSK9 is not sufficient to induce complex formation between PCSK9 and the LDL receptor.

LDLR PCSK9

2.58e-052177224486405
Pubmed

Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.

ABCA2 LDLR

2.58e-052177222748276
Pubmed

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.

RASA4 RASA4B

2.58e-052177211448776
Pubmed

Urokinase-type plasminogen activator receptor is required for impairing toll-like receptor 7 signaling on macrophage efferocytosis in lupus.

TLR7 PLAUR

2.58e-052177232911323
Pubmed

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor.

LDLR PCSK9

2.58e-052177218753623
Pubmed

PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells.

LDLR PCSK9

2.58e-052177225110901
Pubmed

A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.

KRT83 KRT86

2.58e-052177215744029
Pubmed

Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblastic leukemia.

VWF THBD

2.58e-052177221150180
Pubmed

Characterization of LDLR rs5925 and PCSK9 rs505151 genetic variants frequencies in healthy subjects from northern Chile: Influence on plasma lipid levels.

LDLR PCSK9

2.58e-052177231441123
Pubmed

Elevated Thyroid Autoantibodies Aggravate Stroke Severity in Euthyroidism with Acute Ischemic Stroke.

TPO TG

2.58e-052177235256895
Pubmed

Cloning and functional characterization of mammalian homologues of the COPII component Sec23.

SEC23B SEC23A

2.58e-05217728898360
Pubmed

Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling.

LDLR PCSK9

2.58e-052177233606190
Pubmed

Effect of a splice site mutation in LDLR gene and two variations in PCSK9 gene in Tunisian families with familial hypercholesterolaemia.

LDLR PCSK9

2.58e-052177221115573
Pubmed

Megalin/gp330 mediates uptake of albumin in renal proximal tubule.

LRP2 ALB

2.58e-05217728898021
Pubmed

Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation.

LDLR PCSK9

2.58e-052177222875854
Pubmed

LDLR and PCSK9 Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA Carriers.

LDLR PCSK9

2.58e-052177226820623
Pubmed

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

LDLR PCSK9

2.58e-052177217452316
Pubmed

PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment.

LDLR PCSK9

2.58e-052177223509406
Pubmed

Impact of LDLR and PCSK9 pathogenic variants in Japanese heterozygous familial hypercholesterolemia patients.

LDLR PCSK9

2.58e-052177231491741
Pubmed

Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese.

LDLR PCSK9

2.58e-052177229802317
Pubmed

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

LDLR PCSK9

2.58e-052177227284008
Pubmed

Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation.

LDLR PCSK9

2.58e-052177222074827
Pubmed

Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia.

VWF THBD

2.58e-052177224243921
Pubmed

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.

LDLR PCSK9

2.58e-052177219443683
Pubmed

Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation.

LDLR PCSK9

2.58e-052177223400816
Pubmed

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

MUC5B SCNN1B

2.58e-052177228435155
Pubmed

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.

LDLR PCSK9

2.58e-052177228894089
Pubmed

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.

SEC23B SEC23A

2.58e-052177230065114
Pubmed

Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding.

LDLR PCSK9

2.58e-052177230617148
Pubmed

Molecular basis for LDL receptor recognition by PCSK9.

LDLR PCSK9

2.58e-052177218250299
Pubmed

Non-hematopoietic deficiency of proprotein convertase subtilisin/kexin type 9 deficiency leads to more severe anemia in a murine model of sickle cell disease.

LDLR PCSK9

2.58e-052177233020528
Pubmed

Mutations in the genes for thyroglobulin and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability.

TPO TG

2.58e-052177227305979
Pubmed

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.

LDLR PCSK9

2.58e-052177233886544
Pubmed

Expression of the Na+/I- symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes.

TPO TG

2.58e-052177210487692
Pubmed

MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress.

MARCHF5 MFN2

2.58e-052177231416892
Pubmed

Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms.

LDLR AGTR1

2.58e-052177223119030
Pubmed

A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.

KRT81 KRT86

2.58e-05217729665406
Pubmed

Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells.

PTBP2 PTBP1

2.58e-052177221768390
Pubmed

Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.

VWF THBD

2.58e-052177219477487
Pubmed

Silencing of hHS6ST2 inhibits progression of pancreatic cancer through inhibition of Notch signalling.

HS6ST2 NOTCH2

2.58e-052177221443520
Pubmed

Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.

LRP2 PCSK9

2.58e-052177237406929
Pubmed

β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells.

LDLR PCSK9

2.58e-052177225913303
Pubmed

Genetic Variants of LDLR and PCSK9 Associated with Variations in Response to Antihypercholesterolemic Effects of Armolipid Plus with Berberine.

LDLR PCSK9

2.58e-052177227015087
Pubmed

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm.

TGFB2 FBN1

2.58e-052177222772368
Pubmed

Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9.

LDLR PCSK9

2.58e-052177228750079
Pubmed

A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

KRT81 KRT86

2.58e-05217729402962
Pubmed

Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice.

LDLR AGTR1

2.58e-052177218274671
Pubmed

The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.

LDLR PCSK9

2.58e-052177223105118
Pubmed

Patterns and tempo of PCSK9 pseudogenizations suggest an ancient divergence in mammalian cholesterol homeostasis mechanisms.

LDLR PCSK9

2.58e-052177233515402
Pubmed

PCSK9-D374Y Suppresses Hepatocyte Migration through Downregulating Free Cholesterol Efflux Rate and Activity of Extracellular Signal-Regulated Kinase.

LDLR PCSK9

2.58e-052177236655117
Pubmed

Screening of PCSK9 and LDLR genetic variants in Familial Hypercholesterolemia (FH) patients in India.

LDLR PCSK9

2.58e-052177233864011
Pubmed

In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex.

LDLR PCSK9

2.58e-052177232106405
Pubmed

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.

LDLR PCSK9

2.58e-052177222081141
Pubmed

Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.

PTBP2 PTBP1

2.58e-052177212213192
Pubmed

Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor.

LDLR PCSK9

2.58e-052177230002483
Pubmed

PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.

PTBP2 PTBP1

2.58e-052177227681424
Pubmed

Proprotein convertase subtilisin/kexin 9 V4I variant with LDLR mutations modifies the phenotype of familial hypercholesterolemia.

LDLR PCSK9

2.58e-052177227206942
Pubmed

A Therapeutic Peptide Vaccine Against PCSK9.

LDLR PCSK9

2.58e-052177228970592
Pubmed

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

LDLR PCSK9

2.58e-052177235985474
Pubmed

Deletion of AT1a (Angiotensin II Type 1a) Receptor or Inhibition of Angiotensinogen Synthesis Attenuates Thoracic Aortopathies in Fibrillin1C1041G/+ Mice.

FBN1 AGTR1

2.58e-052177234407634
Pubmed

A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.

SEC24C SEC23A

2.58e-052177223658022
Pubmed

A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.

LDLR PCSK9

2.58e-052177220172854
Pubmed

Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice.

LDLR PCSK9

2.58e-052177217242417
Pubmed

Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia.

LDLR PCSK9

2.58e-052177216183066
Pubmed

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

LDLR PCSK9

2.58e-052177220498851
Pubmed

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.

LDLR PCSK9

2.58e-052177217461796
InteractionIGFL3 interactions

TMEM67 LAMB1 ATE1 LDLR LRP2 NOTCH2 MGRN1

3.42e-06751717int:IGFL3
InteractionZFP41 interactions

KBTBD6 LDLR KBTBD7 FBN1 LRP2 NOTCH2

8.67e-06571716int:ZFP41
InteractionGREM2 interactions

KBTBD6 LDLR KBTBD7 LRP2 NOTCH2

1.45e-05371715int:GREM2
Cytoband10q24.3

TRIM8 ALDH18A1

2.19e-046177210q24.3
Cytoband19p13.2

MBD3L5 MBD3L2 MBD3L3 MBD3L4 LDLR MBD3L2B

2.78e-04229177619p13.2
Cytoband7q22

ZAN LAMB1 RASA4

4.30e-043817737q22
GeneFamilyGap junction proteins

GJD2 GJA9 GJA10

4.10e-04221213314
GeneFamilyCholinergic receptors muscarinic

CHRM2 CHRM5

4.38e-0451212180
GeneFamilyRing finger proteins

RNF166 MKRN2 COP1 TRIM3 RNF157 MARCHF5 TRIM8 MGRN1

5.29e-04275121858
GeneFamilyKeratins, type II

KRT81 KRT83 KRT86

7.61e-04271213609
GeneFamilyFibulins

EFEMP1 HMCN2

1.21e-0381212556
GeneFamilyArfGAPs

AGAP7P AGAP4 AGAP6

1.38e-03331213395
GeneFamilyPleckstrin homology domain containing|SH2 domain containing|C2 and RasGAP domain containing

RASA4 RASA4B

1.93e-03101212830
GeneFamilyLow density lipoprotein receptors

LDLR LRP2

3.30e-03131212634
GeneFamilyIntegrator complex

INTS7 INTS1

4.41e-031512121366
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ADNP ZFHX4

4.41e-03151212529
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP4 AGAP6

5.66e-031712121291
GeneFamilyAnkyrin repeat domain containing

ANKRD36 AGAP7P TNKS2 AGAP4 AGAP6 NOTCH2

5.78e-032421216403
CoexpressionNABA_ECM_GLYCOPROTEINS

VWF LAMB1 TECTA SVEP1 FBN1 EFEMP1 HMCN2 OTOGL SLIT3

5.84e-061911759MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

VWF LAMB1 TECTA SVEP1 FBN1 EFEMP1 HMCN2 SLIT3 FBN3

7.20e-061961759M3008
CoexpressionGSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_DN

TMEM67 HMCN2 ZC2HC1A RASA4 MARCHF5 CCNL1 PLAUR NOTCH2

1.97e-051701758M6855
ToppCellBronchus_Control_(B.)-Stromal-TX|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ITGA11 ZNF521 LAMB1 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 CHRD

1.08e-07200176969b41f5fb370aa8840a9ad7919d03ef1e57d1b5b
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

FNDC3B GPR4 VWF ADAM15 ZNF521 NR2F2 THBD FBN1 RASA4

1.08e-072001769e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CECR2 MUC5B TECTA SVEP1 ZFHX4 PIK3C2G MOV10L1 LRP2

2.51e-071601768c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CECR2 MUC5B TECTA SVEP1 ZFHX4 PIK3C2G MOV10L1 LRP2

2.51e-07160176825c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

ITGA11 ZNF521 LAMB1 SVEP1 FBN1 PTPRN SLIT3 IGFL2

6.42e-071811768bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR4 VWF ADAM15 THBD MCTP1 RASA4 ADAMTS18 RASA4B

9.26e-071901768141266bf411ea675fbf889b20c1b08673c45ff95
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC3B ITGA11 LAMB1 GFRA1 SVEP1 FBN1 CHRD RECK

1.00e-061921768671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC3B ITGA11 LAMB1 GFRA1 SVEP1 FBN1 CHRD RECK

1.00e-061921768840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAMP1 LAMB1 CHRM2 GFRA1 SVEP1 EFEMP1 HMCN2 ZFHX4

1.00e-06192176820ede290e01ad574afd122d72b59dbc52c595fad
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 LAMB1 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.04e-061931768c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 LAMB1 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.04e-0619317685b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.13e-061951768cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.13e-061951768783bfa8110161cbd6def50ce849cae676c39c458
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.17e-061961768a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 NR2F2 SVEP1 FBN1 AGTR1 SLIT3

1.17e-061961768ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 NR2F2 SVEP1 FBN1 AGTR1 SLIT3

1.17e-06196176830ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 LAMB1 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.17e-0619617683a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.17e-0619617683e6803587d8566fd08cb8b290be3b6461743d79c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 LAMB1 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.17e-061961768bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.22e-061971768ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.22e-06197176837f6b6f2809b952382eaebb642b0aad6371f4251
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.22e-06197176880e153790cef37b743e22a7370ff5b3a6abf147d
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

UBR2 RTTN IFI44 HELB CCNL1 ANKRD36 UTY ZNF292

1.31e-061991768f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA11 ZNF521 LAMB1 GFRA1 SVEP1 FBN1 ZFHX4 SLIT3

1.31e-061991768abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

ITGA11 ZNF521 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 CHRD

1.36e-0620017682022df85df94ab8cbb4e80e3fe9894c01051c5e0
ToppCellIonocyte-iono-1|World / Class top

ZNF521 FANCM TEKT5 ADHFE1 RASA4 SCNN1B EDRF1

5.03e-0616917674b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

XPC GFRA1 SVEP1 ADHFE1 AGTR1 TMPO ZNF292

5.03e-06169176784b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 ZFHX4 SLIT3

6.81e-061771767b872ee91e01265b101b81bd304cf6b95d5419e68
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMB1 CHRM2 NR2F2 OTOGL AGTR1 SLIT3 CHRD

7.33e-061791767dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 SLIT3 CHRD

8.17e-061821767b7d532feb73167e05475855061b35a209583f44c
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF ZAN ADAM15 ZNF521 THBD FBN1 MCTP1

8.17e-061821767d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHRM2 NR2F2 SVEP1 TGFB2 ADGRE5 FBN3 NOTCH2

8.17e-061821767d3a037268f026eb2f84428b1821022503cef7756
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHB2 TPO ITGA11 TECTA MCTP1 SEMA5B SLIT3

8.17e-06182176772e65a23cd36085bc880087d3cae92395de918a1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 SLIT3 CHRD

8.17e-061821767af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHB2 TPO ITGA11 TECTA MCTP1 SEMA5B SLIT3

8.17e-06182176705c167158815bf25d509df59ab386e1990712765
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBX15 ITGA11 SVEP1 THBD FBN1 EFEMP1 SLIT3

8.47e-0618317675cfcd589a480e67654d3d94e71916f122150db10
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBX15 ITGA11 SVEP1 THBD FBN1 EFEMP1 SLIT3

8.47e-061831767c3ea8d3b916ffcaca3156e0d77a952724554c4ab
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBX15 ITGA11 SVEP1 THBD FBN1 EFEMP1 SLIT3

8.47e-06183176781003ddc24164959dd41bb12fcac72638789b8f2
ToppCellCF-Myeloid-Neutrophil|CF / Disease state, Lineage and Cell class

FNDC3B FBXL13 LITAF FBXL5 TG MCTP1 PLAUR

8.47e-061831767da43827952e6fdee2ce94648c316182f272b321c
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

ITGA11 ZNF521 GFRA1 SVEP1 FBN1 SLIT3 CHRD

8.77e-0618417672b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NR2F2 FBN1 EFEMP1 ZFHX4 SEMA5B AGTR1 SLIT3

8.77e-0618417674d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHRM2 NR2F2 SVEP1 TGFB2 EFEMP1 ADGRE5 FBN3

9.09e-0618517670b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 RAMP1 SVEP1 THBD FBN1 EFEMP1 SLIT3

9.41e-061861767ff6ccfdf2509f96caa10281c29a95b432f6c6dcc
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGA11 GFRA1 NR2F2 SVEP1 ZFHX4 AGTR1 SLIT3

9.75e-06187176776bfe8c42430a230a8bdf299575c444fb7780f24
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 SVEP1 FBN1 EFEMP1 SLIT3 LRP2 LOXL4

9.75e-0618717674e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 SVEP1 FBN1 EFEMP1 SLIT3 LRP2 LOXL4

9.75e-061871767d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 SVEP1 FBN1 EFEMP1 SLIT3 LRP2 LOXL4

9.75e-061871767827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR4 VWF ADAM15 ZNF521 NR2F2 THBD ADAMTS18

9.75e-061871767d6765854154557794815514c0aa355bc74b8523e
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ZNF521 LAMB1 CHRM2 GFRA1 SVEP1 FBN1 SLIT3

9.75e-061871767bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_3|COVID-19_Convalescent / Disease condition and Cell class

ZMYND11 FLT3LG LAMB1 THBD IQSEC1 PLCB3 EDRF1

1.04e-051891767732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 SVEP1 THBD FBN1 EFEMP1 ZFHX4 SLIT3

1.04e-051891767bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.08e-0519017672306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SPEG NR2F2 SVEP1 FBN1 SLIT3

1.08e-05190176770c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.08e-0519017671f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 SVEP1 THBD FBN1 EFEMP1 ZFHX4 SLIT3

1.08e-051901767f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

TPO VWF ADAM15 IFI44 ZNF521 THBD MCTP1

1.08e-05190176778e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 SVEP1 THBD FBN1 EFEMP1 ZFHX4 SLIT3

1.08e-051901767c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.12e-051911767a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellcontrol-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

UBR2 FBXL13 LITAF COP1 THBD ADGRE5 PLAUR

1.12e-051911767db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAMP1 SPEG GFRA1 NR2F2 SVEP1 SLIT3 NOTCH2

1.12e-05191176714057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.16e-0519217679093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 SLIT3

1.16e-051921767d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.16e-0519217679ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell|Adult / Lineage, Cell type, age group and donor

ITGA11 ZNF521 GFRA1 SVEP1 FBN1 EFEMP1 SLIT3

1.16e-051921767d21f0f577156f17c899b08871046a26b88aea011
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.20e-051931767f1199518c3626fd29bfce65070dd21a660671213
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TPO VWF MCHR1 ADAM15 THBD MCTP1 RASA4

1.20e-051931767c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCellfacs-MAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 NR2F2 SVEP1 THBD FBN1 EFEMP1 SLIT3

1.24e-051941767f906b090f67df4cfe3498cdbb52cc0efa08e06cc
ToppCellfacs-MAT-Fat-18m-Mesenchymal|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 NR2F2 SVEP1 THBD FBN1 EFEMP1 SLIT3

1.24e-051941767944cdb0403d80a10a2eea2a3516a9343dbccc32c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SVEP1 FBN1 AGTR1 SLIT3 CHRD

1.24e-051941767240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

ITGA11 LAMB1 SVEP1 FBN1 EFEMP1 HMCN2 NOTCH2

1.24e-051941767d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SVEP1 FBN1 AGTR1 SLIT3 CHRD

1.24e-051941767ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAMP1 LAMB1 GFRA1 NR2F2 SVEP1 FBN1 SLIT3

1.24e-0519417676e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 SLIT3

1.24e-051941767e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TMEM67 ADAM15 RTTN G2E3 IFT122 ANKRD36 KNL1

1.24e-051941767dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellfacs-MAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 NR2F2 SVEP1 THBD FBN1 EFEMP1 SLIT3

1.24e-05194176785081d255fcc1e9854c0073321dd9f0feaa48866
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 NR2F2 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.28e-051951767d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 ZFHX4 SLIT3

1.28e-05195176749c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 ZFHX4 SLIT3

1.28e-051951767dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGA11 GFRA1 NR2F2 SVEP1 FBN1 ZFHX4 SLIT3

1.28e-0519517673d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 NR2F2 THBD FBN1 EFEMP1 ZFHX4 LRP2

1.32e-0519617676bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB1 NR2F2 THBD FBN1 EFEMP1 ZFHX4 LRP2

1.32e-051961767c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 SLIT3 ADGRE5

1.32e-051961767fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 NR2F2 SVEP1 FBN1 SLIT3 ADGRE5

1.32e-051961767802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TPO VWF ZNF521 NR2F2 THBD MCTP1 RASA4

1.37e-05197176787eda06344498dc66cac292cf89746dc90b5cf67
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 GFRA1 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.37e-05197176709946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GPR4 VWF ZNF521 LAMB1 NR2F2 THBD ADAMTS18

1.37e-0519717674e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.37e-0519717676d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMB1 GFRA1 SVEP1 FBN1 EFEMP1 AGTR1 SLIT3

1.37e-051971767ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMB1 GFRA1 SVEP1 FBN1 EFEMP1 AGTR1 SLIT3

1.37e-0519717673bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCelldistal-3-Endothelial-Lymphatic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF521 NR2F2 THBD EFEMP1 ZFHX4 PIK3C2G SCNN1B

1.37e-0519717679ea0e2ed9c3f97591a06e70570640996580417d5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.37e-051971767b349f8e96d61a4c296af64711e11fc44459a9413
ToppCellmLN-(2)_B_cell-(20)_B_cell_IgA_Plasma|mLN / shred on region, Cell_type, and subtype

TBX15 FNDC3B CECR2 TTC36 CLPTM1L FBN1 SCNN1B

1.37e-051971767a39b384ee9824a08c3b544a9c3c7f0f95f08d6a7
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMB1 GFRA1 SVEP1 FBN1 EFEMP1 AGTR1 SLIT3

1.37e-05197176717344464fdcc5ba0c03959696b97c195f11e644c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 GFRA1 SVEP1 FBN1 AGTR1 SLIT3

1.37e-0519717674cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMB1 GFRA1 SVEP1 FBN1 EFEMP1 AGTR1 SLIT3

1.37e-0519717675b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellmLN-B_cell-B_cell_IgA_Plasma|mLN / Region, Cell class and subclass

TBX15 FNDC3B CECR2 TTC36 CLPTM1L FBN1 SCNN1B

1.37e-05197176720822fce311326765b71337ce501ba44ea14f58f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SVEP1 FBN1 AGTR1 SLIT3 ADGRE5

1.37e-051971767c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA11 RAMP1 SVEP1 FBN1 ZFHX4 AGTR1 SLIT3

1.41e-05198176779576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAMP1 LAMB1 GFRA1 SVEP1 EFEMP1 HMCN2 ZFHX4

1.41e-05198176712cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR4 VWF ZNF521 NR2F2 THBD MCTP1 RASA4

1.46e-05199176707bda4ac8ffdce1a865ebc99e46c2a27925ff7a8
DrugRgd Peptide

RALGDS ITGA11 VWF ADAM15 SPEG LAMB1 THBD FBN1 AGTR1 ADGRE5 PLAUR FBN3

3.52e-0723917512CID000104802
DrugMonensin sodium salt [22373-78-0]; Up 200; 5.8uM; MCF7; HT_HG-U133A

ADAM15 LDLR ZFPL1 SLC17A5 ADGRE5 PLCB3 BTRC SEC23A ZNF292

6.32e-0616817593443_UP
DrugNsc34399

TECTA CHRM2 CHRM5

8.78e-0661753CID000003622
Drugdictamnine

KRT81 KRT83 AFM

8.78e-0661753CID000068085
Drugphenylacetaldehyde

RNLS SPINK1 COP1 PTBP1 ADHFE1 LOXL4 ALDH3A2

1.23e-051001757CID000000998
Drug3-sulfoglucuronic acid

THBD AGTR1 CHRD

1.53e-0571753CID000130628
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

TGFB2 THBD TMEM209 MFN2 TMPO TNKS2 RECK EDRF1 SEC23A

1.85e-0519217593753_DN
DrugMethylhydantoin-5-(L) [40856-73-3]; Down 200; 35uM; MCF7; HT_HG-U133A

EPHB2 ABCA2 CDC42BPA IQSEC2 MUC5B ZFHX4 PLAUR UTY ZNF292

1.93e-0519317593378_DN
DrugClofilium tosylate [92953-10-1]; Down 200; 7.8uM; PC3; HT_HG-U133A

EPHB2 ZNF821 ABCA2 SPEG IQSEC2 IDH3G NR2F2 SVEP1 BTRC

2.01e-0519417594492_DN
Drug5-methoxytryptophol

RNLS TECTA MALT1 LOXL4

2.21e-05221754CID000012835
DrugMeprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; MCF7; HT_HG-U133A

ABCA2 ADAM15 INTS1 LAMB1 ZFPL1 GSTCD TMEM209 TMPO NOTCH2

2.26e-0519717593544_DN
DrugDiprophylline [479-18-5]; Down 200; 15.8uM; MCF7; HT_HG-U133A

ZNF821 CDC42BPA SLC17A5 RPAP1 HPS4 GSTCD LRP2 ZFYVE26 ALDH3A2

2.26e-0519717595482_DN
DrugBezafibrate [41859-67-0]; Down 200; 11uM; MCF7; HT_HG-U133A

ASPHD1 ADAM15 LDLR ZFPL1 TGFB2 RPAP1 HPS4 TMPO SEC23A

2.36e-0519817594999_DN
DrugSulfamerazine [127-79-7]; Down 200; 15.2uM; MCF7; HT_HG-U133A

EPHB2 UBR2 INTS7 ABCC5 TGFB2 THBD PLAUR BTRC ZNF292

2.45e-0519917596036_DN
DrugCiprofibrate [52214-84-3]; Down 200; 13.8uM; PC3; HT_HG-U133A

EPHB2 ABCA2 CDC42BPA ERAP1 IFI44 SVEP1 TGFB2 LRP2 PLCB3

2.45e-0519917595740_DN
DrugGraveoline [485-61-0]; Down 200; 14.4uM; MCF7; HT_HG-U133A

INTS7 ADAM15 LAMB1 TRIM3 TGFB2 MALT1 ZFHX4 GSTCD BTRC

2.55e-0520017596034_DN
DrugLilly 51641

RNLS ADHFE1 LOXL4

3.62e-0591753CID000021485
Drugdodecanal

TPO ADHFE1 ALDH3A2

3.62e-0591753CID000008194
Drughematin

TPO KRT81 KRT83 TG GSTCD ALB

4.09e-05821756CID000027337
Drugmelicopicine

KRT81 KRT83

5.87e-0521752CID000101253
Drugdimethyl-W84

CHRM2 CHRM5

5.87e-0521752ctd:C113497
Drugtebuquine

KRT81 KRT83

5.87e-0521752CID000071991
Drug3,5-di-O-galloylquinic acid

KRT81 KRT83

5.87e-0521752CID000460896
DrugFurazolidone-d4

RNLS HPS4 LOXL4 ALDH3A2

7.91e-05301754CID000003435
DrugForskolin, from Coleus forskohlii; Up 200; 0.5uM; PC3; HT_HG-U133A

EPHB2 ERAP1 TRIM3 TGFB2 THBD FBN1 PACS2 PLCB3

8.86e-0518317587059_UP
DrugGanciclovir [82410-32-0]; Down 200; 15.6uM; MCF7; HT_HG-U133A

ERAP1 SPEG TRIM3 TGFB2 RPAP1 ZFHX4 MIOS TMPO

1.03e-0418717583368_DN
Drug3-isoreserpine

ABCA2 RNLS ABCC5 CHRM2 LDLR SLC17A5 PIK3C2G LOXL4

1.15e-041901758CID000005052
DrugHomochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A

RALGDS IQSEC2 LDLR SVEP1 FBXL5 THBD HPS4 ALDH3A2

1.19e-0419117587417_UP
DrugQuinacrine dihydrochloride dihydrate [6151-30-0]; Up 200; 7.8uM; HL60; HG-U133A

UBR2 DIDO1 MALT1 ZC2HC1A RPAP1 TRIM8 RECK SEC23B

1.19e-0419117581563_UP
Drugtrioxane

KRT81 KRT83 HPS4

1.21e-04131753CID000008081
DrugThalidomide [50-35-1]; Down 200; 15.4uM; MCF7; HT_HG-U133A

ASPHD1 INTS7 IQSEC2 MKRN2 ZFPL1 HPS4 UTY BTRC

1.24e-0419217585990_DN
DrugPipenzolate bromide [125-51-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A

ABCA2 IQSEC2 LAMB1 TRIM3 TGFB2 TMEM209 PLAUR EDRF1

1.24e-0419217583460_UP
Drugscriptaid; Down 200; 10uM; PC3; HT_HG-U133A

AIP PTBP1 ADNP LDLR ZFPL1 TMPO PLAUR NOTCH2

1.24e-0419217586919_DN
Drugradicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A

UBR2 CDC42BPA ASPHD1 IQSEC2 DIDO1 CHRM5 EFEMP1 EDRF1

1.28e-0419317586938_UP
Druggenistein; Down 200; 10uM; MCF7; HT_HG-U133A

ZMYND11 PTBP1 LDLR ZFPL1 SLC17A5 MFN2 TMPO SEC23A

1.28e-0419317585232_DN
DrugGlycocholic acid [475-31-0]; Down 200; 8.6uM; PC3; HT_HG-U133A

CDC42BPA SPEG ZFPL1 TGFB2 MFN2 ALDH18A1 SEC23A NOTCH2

1.28e-0419317586716_DN
DrugAG-013608 [351320-38-2]; Down 200; 10uM; PC3; HT_HG-U133A

ZNF821 ADAM15 LDLR TGFB2 MFN2 ALDH18A1 BTRC NOTCH2

1.28e-0419317585909_DN
Drugharmaline

GJD2 RNLS TMPO LOXL4

1.31e-04341754CID000022381
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

GPR4 ADAM15 AIP PTBP1 LDLR ALDH18A1 TMPO NOTCH2

1.33e-0419417586918_DN
Drug17-DMAG; Up 200; 0.1uM; PC3; HT_HG-U133A

GPR4 RALGDS FPGS IQSEC2 DIDO1 MUC5B HPS4 EDRF1

1.33e-0419417581213_UP
DrugSolanine alpha [20562-02-1]; Down 200; 4.6uM; MCF7; HT_HG-U133A

CDC42BPA FPGS TMEM209 TMPO ADGRE5 TNKS2 EDRF1 NOTCH2

1.38e-0419517582808_DN
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; MCF7; HT_HG-U133A

ZNF821 ABCA2 ASPHD1 IQSEC2 LAMB1 TRIM3 MALT1 PLCB3

1.38e-0419517586082_DN
DrugDicumarol [66-76-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

EPHB2 RALGDS MUC5B TRIM3 ZFPL1 MIOS ADGRE5 PLCB3

1.38e-0419517583941_DN
DrugAmikacin hydrate [37517-28-5]; Down 200; 6.6uM; MCF7; HT_HG-U133A

RALGDS ZNF821 ABCA2 CDC42BPA TMEM209 LRP2 HMGXB3 NOTCH2

1.42e-0419617583233_DN
DrugChlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; MCF7; HT_HG-U133A

EPHB2 RALGDS CDC42BPA ADAM15 FBXL5 RPAP1 TMPO TNKS2

1.42e-0419617582627_DN
DrugHydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ABCA2 IQSEC2 NR2F2 MALT1 HPS4 TMEM209 BTRC ZNF292

1.48e-0419717586011_DN
DrugClozapine [5786-21-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A

EPHB2 ZNF821 LAMB1 ZFPL1 FBXL5 HPS4 IQSEC1 HMGXB3

1.48e-0419717582644_DN
DrugSuprofen [40828-46-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A

RAMP1 KRT83 IQSEC2 TRIM3 THBD MFN2 ADGRE5 BTRC

1.48e-0419717584123_DN
DrugColistin sulfate [1264-72-8]; Up 200; 3uM; MCF7; HT_HG-U133A

RALGDS TRIM3 GSTCD TMEM209 MFN2 BTRC SEC23A NOTCH2

1.48e-0419717584796_UP
DrugSulfabenzamide [127-71-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A

LAMB1 TRIM3 FBXL5 TMEM209 ADGRE5 HMGXB3 PLCB3 BTRC

1.48e-0419717582814_DN
DrugAlclometasone dipropionate [667634-13-2]; Down 200; 7.6uM; PC3; HT_HG-U133A

ABCA2 IFI44 MCTP1 LRP2 IFT122 BTRC EDRF1 NOTCH2

1.48e-0419717585752_DN
Drugfludrocortisone acetate; Up 200; 1uM; MCF7; HG-U133A

IDH3G LDLR TG SLIT3 TMPO UTY EDRF1 SEC23B

1.48e-041971758281_UP
Drugaspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A

RALGDS ASPHD1 LAMB1 NR2F2 TGFB2 MALT1 PLCB3 EDRF1

1.48e-0419717585564_DN
DrugNiacin [59-67-6]; Down 200; 32.4uM; MCF7; HT_HG-U133A

ABCA2 CDC42BPA TRIM3 SLC17A5 ADGRE5 HMGXB3 UTY NOTCH2

1.48e-0419717585301_DN
DrugMemantine Hydrochloride [41100-52-1]; Up 200; 18.6uM; HL60; HT_HG-U133A

ZNF821 IQSEC2 IDH3G TRIM3 AGTR1 IQSEC1 MIOS UTY

1.48e-0419717582934_UP
Drugsodium perchlorate hydrate

TPO TG IFT122

1.53e-04141753CID000516899
DrugDiazoxide [364-98-7]; Down 200; 17.4uM; MCF7; HT_HG-U133A

EPHB2 ABCA2 RAMP1 ASPHD1 FPGS NR2F2 RPAP1 PLAUR

1.53e-0419817587168_DN
DrugFipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; PC3; HT_HG-U133A

ABCA2 IFI44 SVEP1 TGFB2 FBN1 PLCB3 UTY EDRF1

1.53e-0419817585737_DN
DrugProgesterone [57-83-0]; Down 200; 12.8uM; MCF7; HT_HG-U133A

EPHB2 RALGDS INTS1 RPAP1 TMPO PLAUR PLCB3 ESPL1

1.53e-0419817584992_DN
DrugTranexamic acid [1197-18-8]; Up 200; 25.4uM; MCF7; HT_HG-U133A

ERAP1 ZFPL1 TGFB2 EFEMP1 GSTCD ADGRE5 ALDH3A2 BTRC

1.53e-0419817586238_UP
DrugDimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A

EPHB2 CDC42BPA ERAP1 IQSEC2 DIDO1 RPAP1 PLAUR UTY

1.53e-0419817584791_DN
DrugEthacrynic acid [58-54-8]; Down 200; 13.2uM; PC3; HT_HG-U133A

EPHB2 GPR4 ABCA2 ADAM15 DIDO1 TMEM209 LRP2 UTY

1.53e-0419817585742_DN
DrugDubinidine [22964-77-8]; Down 200; 14.6uM; MCF7; HT_HG-U133A

ZNF821 ASPHD1 ZFPL1 RPAP1 GSTCD TNKS2 EDRF1 ZNF292

1.53e-0419817583554_DN
DrugCyclopenthiazide [742-20-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A

ZNF821 TRIM3 MALT1 THBD MCTP1 ZFHX4 BTRC EDRF1

1.53e-0419817587325_UP
DrugRauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A

RALGDS TRIM3 RPAP1 ADGRE5 PLAUR PLCB3 TNKS2 EDRF1

1.58e-0419917582778_DN
DrugArtemisinin [63968-64-9]; Down 200; 14.2uM; PC3; HT_HG-U133A

GPR4 MUC5B IDH3G LDLR TGFB2 FBN1 MFN2 UTY

1.58e-0419917587247_DN
DrugIsoniazid [54-85-3]; Down 200; 29.2uM; HL60; HG-U133A

ABCA2 CDC42BPA ADAM15 ABCC5 IDH3G LDLR ALDH3A2 RECK

1.58e-0419917581399_DN
Drugsemustine; Down 200; 100uM; MCF7; HT_HG-U133A

LAMB1 NR2F2 EFEMP1 GSTCD LRP2 TMPO PLAUR BTRC

1.58e-0419917587487_DN
DrugOzagrel hydrochloride [78712-43-3]; Down 200; 15.2uM; PC3; HT_HG-U133A

FPGS IDH3G NR2F2 TRIM3 TGFB2 TMEM209 HMGXB3 PLCB3

1.58e-0419917587281_DN
DrugOrnidazole [16773-42-5]; Up 200; 18.2uM; MCF7; HT_HG-U133A

ABCA2 KRT83 TRIM3 MCTP1 ZFHX4 PIK3C2G TMEM209 SCNN1B

1.64e-0420017582272_UP
Drugsulfonamide-3

KRT81 KRT83

1.75e-0431752CID009847197
DiseaseMONILETHRIX

KRT81 KRT83 KRT86

1.75e-0731663158000
DiseaseBeaded hair

KRT81 KRT83 KRT86

1.75e-0731663cv:C0546966
Diseasemonilethrix (is_implicated_in)

KRT81 KRT83 KRT86

1.75e-0731663DOID:0050472 (is_implicated_in)
DiseaseMonilethrix

KRT81 KRT83 KRT86

6.97e-0741663C0546966
Diseaseend stage renal disease (is_marker_for)

VWF RNLS THBD PLAUR ALB

6.03e-06461665DOID:783 (is_marker_for)
Diseasecerebral palsy (implicated_via_orthology)

AGAP7P AGAP4 AGAP6

2.04e-05101663DOID:1969 (implicated_via_orthology)
Diseasecongenital dyserythropoietic anemia type II (implicated_via_orthology)

SEC23B SEC23A

3.15e-0521662DOID:0111401 (implicated_via_orthology)
Diseasecraniolenticulosutural dysplasia (implicated_via_orthology)

SEC23B SEC23A

3.15e-0521662DOID:0070307 (implicated_via_orthology)
Diseasehair disease (is_implicated_in)

KRT81 KRT86

3.15e-0521662DOID:421 (is_implicated_in)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

9.40e-0531662DOID:65 (implicated_via_orthology)
DiseaseSushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 measurement

ADAM15 SVEP1

1.87e-0441662EFO_0803113
DiseaseRoberts syndrome (implicated_via_orthology)

SEC23B SEC23A

1.87e-0441662DOID:5325 (implicated_via_orthology)
DiseaseIntellectual Disability

RALGDS ZMYND11 RTTN ZBTB24 TRIM8 IQSEC1 LRP2 PACS2 ALDH3A2 ZNF292

2.34e-0444716610C3714756
Diseasemyocardial infarction (biomarker_via_orthology)

VWF TGFB2 AGTR1 MFN2 PLAUR PLCB3

3.01e-041601666DOID:5844 (biomarker_via_orthology)
Disease3-methylcytidine measurement

FBXL5 LOXL4

3.11e-0451662EFO_0800633
DiseaseThyroid Dyshormonogenesis 1

TPO TG

4.65e-0461662C1848805
Diseasefamilial combined hyperlipidemia (is_marker_for)

VWF THBD

4.65e-0461662DOID:13809 (is_marker_for)
Diseaselevel of Sphingomyelin (d42:2) in blood serum

LDLR PELP1 PCSK9

5.74e-04291663OBA_2045183
DiseaseLDL cholesterol change measurement

LDLR PCSK9

6.49e-0471662EFO_0007804
DiseaseAortic Aneurysm, Thoracic

TGFB2 FBN1

6.49e-0471662C0162872
DiseaseGoiter

TPO TG

6.49e-0471662C0018021
DiseaseAortic Aneurysm, Thoracoabdominal

TGFB2 FBN1

6.49e-0471662C0340630
Diseasepulse pressure measurement, anxiety

GJA9 GJA10

6.49e-0471662EFO_0005230, EFO_0005763
DiseaseAutistic Disorder

ZMYND11 COP1 LAMB1 XPC ADNP PLAUR ZNF292

7.19e-042611667C0004352
Diseaserefractive error, age at onset, Myopia

FNDC3B GJD2 RNLS FBN1 EFEMP1 RORB

8.09e-041931666EFO_0004847, HP_0000545, MONDO_0004892
DiseaseAbnormality of the skeletal system

INTS1 ZNF292

8.61e-0481662C4021790
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

VWF FBN1

8.61e-0481662DOID:4783 (biomarker_via_orthology)
DiseaseFamilial hypercholesterolemia

LDLR PCSK9

8.61e-0481662cv:C0020445
Diseasediastolic blood pressure, self reported educational attainment

PIK3C2G SLIT3

8.61e-0481662EFO_0004784, EFO_0006336
DiseasePituitary Neoplasms

AIP AGTR1

8.61e-0481662C0032019
Diseaserefractive error, self reported educational attainment

GJD2 DIS3L FBN1

9.20e-04341663EFO_0004784, MONDO_0004892
Diseasemonocyte percentage of leukocytes

UBR2 FLT3LG CDC42BPA RNLS LITAF CECR2 IQSEC2 MKRN2 ABCC5 ZC2HC1A HMGXB3 PLAUR

9.26e-0473116612EFO_0007989
Diseasemultiple myeloma (is_marker_for)

FLT3LG ALB NOTCH2

1.09e-03361663DOID:9538 (is_marker_for)
DiseaseKunitz-type protease inhibitor 1 measurement

GJD2 GJA9

1.10e-0391662EFO_0008199
Diseaseaortic aneurysm

TGFB2 FBN1

1.37e-03101662EFO_0001666
Diseasefamilial hypercholesterolemia (is_implicated_in)

LDLR PCSK9

1.37e-03101662DOID:13810 (is_implicated_in)
Diseaseglomerulosclerosis (biomarker_via_orthology)

RNLS AGTR1

1.37e-03101662DOID:0050851 (biomarker_via_orthology)
DiseaseLiver Cirrhosis, Experimental

VWF RAMP1 ERAP1 TTC36 ABCC5 GFRA1 THBD ADHFE1 FBN1 AFM ALB RECK

1.50e-0377416612C0023893
Diseasephotoreceptor cell layer thickness measurement

UBR2 CDC42BPA ATE1 RORB IFT122

1.54e-031481665EFO_0803370
DiseaseKidney Diseases

AGTR1 LRP2 IFT122 ALB

1.56e-03881664C0022658
DiseaseDiaphragmatic Hernia

NR2F2 SLIT3 LRP2

1.59e-03411663C0019284
Diseaseamino acid measurement

EPHB2 ITGA11 VWF LITAF LAMB1 CHRM2 PELP1 SLIT3 SCNN1B LRP2 TNKS2

1.65e-0367816611EFO_0005134
DiseaseAutoimmune Diseases

TPO TG TGFB2

1.71e-03421663C0004364
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

NR2F2 SLIT3

2.00e-03121662DOID:3827 (implicated_via_orthology)
Diseaseautoimmune thyroiditis (is_implicated_in)

TG LRP2

2.00e-03121662DOID:7188 (is_implicated_in)
Diseasefamilial hyperlipidemia (implicated_via_orthology)

LDLR ALB

2.00e-03121662DOID:1168 (implicated_via_orthology)
DiseaseEndometrioma

LAMB1 NR2F2 TGFB2 FBN1 RORB

2.22e-031611665C0269102
DiseaseEndometriosis

LAMB1 NR2F2 TGFB2 FBN1 RORB

2.22e-031611665C0014175
DiseaseCongenital Hypothyroidism

TPO TG

2.36e-03131662C0010308
Diseaseatherosclerosis

SLC17A4 LDLR

2.36e-03131662EFO_0003914
Diseasepancreatic cancer (is_marker_for)

ADAM15 ABCC5 ADGRE5 ALB

2.58e-031011664DOID:1793 (is_marker_for)
Diseaseobesity (is_marker_for)

VWF THBD MFN2 PLAUR

2.58e-031011664DOID:9970 (is_marker_for)
DiseaseMalignant neoplasm of prostate

EPHB2 SPINK1 LITAF USP28 ARHGEF5 CLPTM1L GSTCD LRP2 PLAUR ZNF292

2.66e-0361616610C0376358
Diseasecongenital hypothyroidism (implicated_via_orthology)

TPO TG

2.74e-03141662DOID:0050328 (implicated_via_orthology)
Diseaseserum IgG glycosylation measurement

TPO ITGA11 IFI44 LAMB1 GFRA1 EFEMP1 MCTP1 SLIT3 RECK

2.94e-035231669EFO_0005193
DiseaseHernia

TGFB2 EFEMP1 HMCN2

2.99e-03511663HP_0100790
DiseaseProteinuria

VWF LRP2

3.15e-03151662HP_0000093
Diseaseresponse to statin, LDL cholesterol change measurement

LDLR PCSK9

3.15e-03151662EFO_0007804, GO_0036273
Diseaselevel of Sterol ester (27:1/18:1) in blood serum

LDLR PCSK9

3.58e-03161662OBA_2045195
Diseaseprimary autosomal recessive microcephaly (is_implicated_in)

NCAPD2 KNL1

3.58e-03161662DOID:0070296 (is_implicated_in)
DiseaseNeoplasm Invasiveness

TBX15 XPC PLAUR RECK NOTCH2

3.93e-031841665C0027626
Diseasewaist-hip ratio

EPHB2 TBX15 FNDC3B ITGA11 ZMYND11 LITAF SLC17A4 LAMB1 CHRM2 RNF157 MARCHF5 TRIM8 PLCB3 IFT122 KNL1

4.01e-03122616615EFO_0004343
DiseaseEye Abnormalities

TGFB2 IFT122

4.05e-03171662C0015393
Diseaseischemia (implicated_via_orthology)

ADNP SCNN1B

4.05e-03171662DOID:326 (implicated_via_orthology)
DiseaseHypermetropia, Myopia

TMEM67 GJD2 RNLS EFEMP1 RORB

4.41e-031891665HP_0000540, HP_0000545
DiseaseHypertensive disease

VWF ERAP1 AGTR1 SCNN1B ALB

4.51e-031901665C0020538
Diseaseandrostenedione measurement, estrone measurement

OR4D1 OR4D2

4.54e-03181662EFO_0007970, EFO_0007972
Diseasesinusitis (is_marker_for)

MUC5B PLAUR

4.54e-03181662DOID:0050127 (is_marker_for)
Diseaseessential hypertension (is_implicated_in)

RNLS AGTR1

4.54e-03181662DOID:10825 (is_implicated_in)
Diseaselevel of Sphingomyelin (d34:1) in blood serum

LDLR PCSK9

4.54e-03181662OBA_2045175
DiseaseHypercholesterolemia, Familial

LDLR PCSK9

4.54e-03181662C0020445
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

LDLR NPC1L1 PLAUR PCSK9

4.79e-031201664EFO_0004611, EFO_0004639
Diseasediastolic blood pressure, systolic blood pressure

TBX15 FNDC3B SPINK1 ADAM15 SPEG FBN1 EFEMP1 PELP1 LOXL4 BTRC

4.79e-0367016610EFO_0006335, EFO_0006336
DiseaseAbnormality of refraction

EPHB2 FNDC3B GJD2 RNLS PTBP1 FBN1 EFEMP1 RORB FBN3 SEC23B

4.94e-0367316610HP_0000539
Diseasebipolar disorder (is_marker_for)

VWF CHRM2

5.05e-03191662DOID:3312 (is_marker_for)
Diseasesmoking behavior, BMI-adjusted waist circumference

TBX15 FNDC3B TGFB2 EFEMP1

5.07e-031221664EFO_0004318, EFO_0007789
DiseaseBMI-adjusted waist circumference, physical activity measurement

TBX15 FNDC3B TGFB2 EFEMP1

5.22e-031231664EFO_0007789, EFO_0008002
Diseasecitrulline measurement

HMCN2 ALDH18A1

5.59e-03201662EFO_0009777

Protein segments in the cluster

PeptideGeneStartEntry
FENRILLNCPYCTFN

ADNP

101

Q9H2P0
SQECINVLLQYGCPD

AGAP4

646

Q96P64
DNNRCPKCNYVVDNI

COP1

166

Q8NHY2
ECCVYIPNNSRNISL

ERVPABLB-1

401

P60509
PCAEDYLSVVLNQLC

ALB

471

P02768
LALAQSQYAQAPCCP

ANTXRL

476

A6NF34
NTLQPGCNQACYDRA

GJD2

56

Q9UKL4
CQLKGPTCQYRAAQS

ADAM15

726

Q13444
IYKDLLRNCCNTENP

AFM

376

P43652
ITICIAYFNNCLNPL

AGTR1

286

P30556
LLECYNSPQVQCLRA

ARHGEF5

1506

Q12774
CNNICYDDAFPISLI

GJA10

61

Q969M2
LRQTYNSCARLCLNQ

BTRC

76

Q9Y297
QNLPRCGIECKSYQE

AAR2

176

Q9Y312
DVDECQQNPRLCKSY

ADGRE5

116

P48960
RQELSYQNLLNVSCC

ANKRD40CL

31

Q53H64
CIAPDYILCEASLQN

ALDH3A2

241

P51648
INSTINPACYALCNA

CHRM2

431

P08172
QCLNRSLYRPDAVAQ

ANKRD36

341

A6QL64
QPETIACACIYLAAR

CCNL1

241

Q9UK58
ACACIYLAARALQIP

CCNL1

246

Q9UK58
QNADCINIPGSYRCK

FBN3

1776

Q75N90
ACLLQGCYQRRDITP

CECR2

61

Q9BXF3
SSRIYQLCNINPCNE

ADAMTS18

631

Q8TE60
LDQQITPLLLNYCQC

AIP

226

O00170
SQECINVLLQYGCPD

AGAP6

646

Q5VW22
CAIASCRQQGSPRYL

CRISP1

156

P54107
NEQQLCPYAAAGECR

MKRN2

166

Q9H000
VPCQSLEAYAELCRA

MUC5B

5326

Q9HC84
GRPQTAYLQCKCVNE

RASA4

646

O43374
ACQEANYGALLRELC

RAMP1

26

O60894
GRPQTAYLQCKCVNE

RASA4B

646

C9J798
DVREPCQLGCRNLTY

RECK

341

O95980
QYECVPRQLACDQVQ

RECK

706

O95980
LSYTCRANRNCPIDQ

NR2F2

111

P24468
NIQALCECALQTPYD

INTS7

291

Q9NVH2
RFYCNNENCSLPLVL

PIK3C2G

681

O75747
LQDVDHYCPNCRALL

LITAF

141

Q99732
RCIDLVNGYQCNCQP

NOTCH2

621

Q04721
NFYCDVPQVLRLACT

OR4D2

176

P58180
LCAYQAEPNTCATAQ

PTPRN

716

Q16849
YLERQLAPENCCFAA

KLHL34

121

Q8N239
TNCPTGLQRRYACAN

LOXL4

646

Q96JB6
LCYRCSTNNPLLNNL

IFT122

1056

Q9HBG6
FCRAELQNPYCKNVQ

MCTP1

436

Q6DN14
NPAEAVQVLRYCCLL

MOV10L1

1036

Q9BXT6
CNQQLDLALCRAYEA

TMPO

561

P42166
LRQLCQYQRCVPQDT

INTS1

1436

Q8N201
PNPYRSENCLCVQNI

MALT1

431

Q9UDY8
SYRALRCPACNENGL

GRXCR2

226

A6NFK2
YCDVDSVSARQPLCQ

EDRF1

1006

Q3B7T1
LQLPKACAYQCHNLQ

HMCN2

4761

Q8NDA2
QLLLYQAGRCQPSNC

ASPHD1

251

Q5U4P2
SCADTLRYQANNCPI

MGRN1

301

O60291
RLIEAFSQRYCICNP

IQSEC1

626

Q6DN90
LIEAFSQRYCVCNPA

IQSEC2

856

Q5JU85
SQRYCVCNPALVRQF

IQSEC2

861

Q5JU85
YQNRECCQSNLEPLF

KRT86

141

O43790
EVCPLNGCDYIVSNR

FANCM

1846

Q8IYD8
VRNASTAVYACCNPI

HPS4

651

Q9NQG7
VALCADLCYPELTNQ

HMGXB3

1106

Q12766
QLCAYRRLQALQPCS

MBD3L5

86

A6NJ08
LLLLACVHNYQPCVQ

ERAP1

731

Q9NZ08
ACTRCGDNVQYAPRQ

EPHB2

371

P29323
TRQNFSRCLELQCQP

FLT3LG

146

P49771
YAIARCCLLPQANCS

PCSK9

521

Q8NBP7
CLANKYRPITGACNN

TPO

146

P07202
QLCAYRRLQALQPCS

MBD3L2B

86

A0A1B0GVZ6
ARVACPQCNAEYLIV

MARCHF5

61

Q9NX47
RSCYQDPVTLQLACV

LAMB1

931

P07942
DNYSCLPNVISCTDN

KNL1

1326

Q8NG31
NSNICIPRVYLCDGD

LRP2

2831

P98164
CQRVLRKPAQDCSAY

ITGA11

806

Q9UKX5
LFSCNRNVLAAACPY

KBTBD7

81

Q8WVZ9
CQVCQSAYSQLAGLR

PRDM12

301

Q9H4Q4
IVSRIQRYCNCNSQP

PACS2

531

Q86VP3
DALSPQLQQLACECY

PELP1

226

Q8IZL8
QLQQLACECYSRLPS

PELP1

231

Q8IZL8
GNTYPNECVLCFENR

SPINK1

51

P00995
SLNCVADPILYCLVN

GPR4

276

P46093
QLCAYRRLQALQPCS

MBD3L3

86

A6NE82
LVPRQCFSLNYDLNC

MFN2

516

O95140
CEYPAACNALETLLI

ALDH18A1

606

P54886
NPDNTSLYDCCINSL

NPC1L1

476

Q9UHC9
HYVCLRNEANQPLCL

PLCB3

821

Q01970
QCLRYIANLISCFPS

GLYATL3

176

Q5SZD4
EERYNSVLNSCCLRP

ABCC5

651

O15440
VQDYRPGACFNIICN

GAL3ST1

126

Q99999
CNNCLAIPITNTYKE

G2E3

666

Q7L622
ACLVQCSREAAPQDY

ESPL1

126

Q14674
LFLQCCREVAARYPQ

IDH3G

231

P51553
LDRCCNQGPTLTVIY

IFI44

41

Q8TCB0
PNCLNLQDSCKTNYI

GFRA1

241

P56159
CRNVCYDQAFPISLI

GJA9

61

P57773
AFYERRSCLPQLNCE

ENTR1

26

Q96C92
CYTALTNGRCSNQLP

FBN1

336

P35555
DINECAQNPLLCAFR

FBN1

2206

P35555
AQNPLLCAFRCVNTY

FBN1

2211

P35555
QPESIACACIYLAAR

CCNL2

236

Q96S94
DLLPAAQYCCRLQAF

FNDC3B

826

Q53EP0
LFANEFQQCCYLPRE

DIS3L

116

Q8TF46
NPLEQCCYNDAIVSL

IGFL2

46

Q6UWQ7
QVLLAYSRCLQACGQ

DDX12P

766

Q92771
LLERNGEDYICPNCT

DIDO1

306

Q9BTC0
ELLQVQQSLGYCPQC

ABCA2

2121

Q9BZC7
SQECINVLLQYGCPD

AGAP7P

646

Q5VUJ5
SERCPNLNYLSLRNC

FBXL13

501

Q8NEE6
SSALPLYNQQVGDCC

RALGDS

786

Q12967
ANSCLNPFVYIVLCE

MCHR1

371

Q99705
CLPSLENSKYCRFNQ

ATE1

441

O95260
LRDRAQQISCPLYLC

FPGS

266

Q05932
YVCPGTECQLLRLQA

HS6ST2

171

Q96MM7
IFSYLNPQELCRCSQ

FBXL5

216

Q9UKA1
AQILACYRKNCASPS

SEC24C

876

P53992
RYIVCSLAQQDCSPG

SLC17A4

266

Q9Y2C5
AAPVCCSARYNLAIL

SLC17A5

31

Q9NRA2
ILACLFGAEPCNYRN

SCNN1B

246

P51168
QNCCLPAVVERSDNF

GSTCD

86

Q8NEC7
CCTRNAYLSDLLPEN

HELB

781

Q8NG08
LFPCNRNVLAAACPY

KBTBD6

81

Q86V97
YQNRECCQSNLEPLF

KRT83

146

P78385
QLCAYRRLQALQPCS

MBD3L4

86

A6NDZ8
NFYCDVPQVLRLACT

OR4D1

176

Q15615
CCRENGVRNLSVPLY

OTOGL

2316

Q3ZCN5
QLCAYRRLQALQPCS

MBD3L2

86

Q8NHZ7
YLLRQLQRAACQCPT

ADHFE1

11

Q8IWW8
NNQYFDISALSCVPC

TMEM67

51

Q5HYA8
CNLPIKVVCRANAEY

MTX2

51

O75431
QNPLLGRACESCYAT

MTA3

371

Q9BTC8
ICQCNQGYELSSDRL

EFEMP1

276

Q12805
LQLLCVYTANFPNGC

RTTN

1971

Q86VV8
RLRDEQLNAPYSCQA

TARS3

31

A2RTX5
SCNQPQDAIKCYLNA

UTY

361

O14607
RANCEYQCQPLNQTS

THBD

371

P07204
CADTLRYQANNCPIC

RNF157

301

Q96PX1
LALDGQNIYNACCTL

PTBP2

236

Q9UKA9
ACPYCGARNLDQQEL

RNF166

151

Q96A37
CRESQLCNLNLSDYP

TBX15

386

Q96SF7
NEVNCPLQVALECLY

TEKT5

181

Q96M29
PCRNQATCVDELNSY

SVEP1

1391

Q4LDE5
ICLYDECNNSPLRRE

CDC42BPA

36

Q5VT25
CRAVLNPLCQVDYRA

SEC23A

66

Q15436
CKAVLNPLCQVDYRA

SEC23B

66

Q15437
VNSTVNPICYALCNR

CHRM5

486

P08912
CSGDANCIQPYLARR

CLPTM1L

36

Q96KA5
CCYRLLENPTINHQK

NCAPD2

201

Q15021
NYDPLCSLCTCQRRT

CHRD

721

Q9H2X0
VLLQTSPCDQYECQN

SLIT3

1116

O75094
QGSCAYLLARQCLQT

TECTA

341

O75443
RNVQDNCCLRPLYID

TGFB2

311

P61812
LQYQCDQCTVAFPTL

ZFHX4

2446

Q86UP3
LENLPQNGRQCYSCK

PLAUR

206

Q03405
PYECNQCGRAFSQLA

ZNF135

521

P52742
QVYLQCGTPCNLTCR

VWF

656

P04275
RLRQNADQCCPEYEC

VWF

2311

P04275
CSTLRLQLNNPYLCV

MIOS

576

Q9NXC5
QPDDDQYCLRICRVS

SPEG

1441

Q15772
NPQCTADLGAQYITC

RNLS

51

Q5VYX0
ECSPNEDRAALQCVY

ZNF521

271

Q96K83
NNASYSCPRQRNCLI

RORB

51

Q92753
VPAVEAATDYCQQLC

ZNF292

41

O60281
AAEYQDCNPQACPVR

SEMA5B

896

Q9P283
CSYLGQDIAENLQLC

USP28

1011

Q96RU2
AQACQDLPSIRNCYL

RPAP1

1046

Q9BWH6
LQILDLSGNCPRCYN

TLR7

251

Q9NYK1
LQTCRLLLSYGCDPN

TNKS2

446

Q9H2K2
YQLACRSQAPCANKD

TMEM209

291

Q96SK2
SCPECNLQFARLDNL

ZBTB24

491

O43167
QCPYCQRRFNENAAD

ZC2HC1A

121

Q96GY0
QLCKNCFYLSNARPD

ZMYND11

256

Q15326
QAICLLPERASAYNN

TTC36

76

A6NLP5
PAGILLVCNNCAAYR

ZNF821

231

O75541
LCLLANGFYRNNICS

XPC

211

Q01831
DSGLVRCPECNQAYN

TRIM8

46

Q9BZR9
LCSYLSLPNNLICLF

UBR2

1546

Q8IWV8
LDGQNIYNACCTLRI

PTBP1

241

P26599
VPSCRRNGDYQAVQC

TG

316

P01266
LARCQQYLCSIPDSL

ZFYVE26

556

Q68DK2
DSDYNPNCRLCNIPL

ZFPL1

46

O95159
FCERCLQNYIPAQSL

TRIM3

41

O75382
ALCRSLQAYASLCAQ

ZAN

1781

Q9Y493
YECLCPDGFQLVAQR

LDLR

336

P01130
YQNRECCQSNLEPLF

KRT81

141

Q14533
ILCDALRYPNCNIQR

NLRP14

976

Q86W24