Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	aminoglycan metabolic process	XYLT1 CTBS CHST9 B4GALT7 GLCE	7.88e-06	132	43	5	GO:0006022
GeneOntologyBiologicalProcess	proteoglycan biosynthetic process	XYLT1 CHST9 B4GALT7 GLCE	1.36e-05	70	43	4	GO:0030166
GeneOntologyBiologicalProcess	response to lead ion	BACE1 CAT FECH	1.88e-05	25	43	3	GO:0010288
GeneOntologyBiologicalProcess	glycosaminoglycan biosynthetic process	XYLT1 CHST9 B4GALT7 GLCE	1.88e-05	76	43	4	GO:0006024
GeneOntologyBiologicalProcess	aminoglycan biosynthetic process	XYLT1 CHST9 B4GALT7 GLCE	2.31e-05	80	43	4	GO:0006023
GeneOntologyBiologicalProcess	proteoglycan metabolic process	XYLT1 CHST9 B4GALT7 GLCE	4.93e-05	97	43	4	GO:0006029
GeneOntologyBiologicalProcess	glycoprotein biosynthetic process	XYLT1 ST8SIA5 CHST9 B4GALT7 ATP4B GLCE	9.15e-05	357	43	6	GO:0009101
GeneOntologyBiologicalProcess	glycosaminoglycan metabolic process	XYLT1 CHST9 B4GALT7 GLCE	1.17e-04	121	43	4	GO:0030203
GeneOntologyBiologicalProcess	glycoprotein metabolic process	XYLT1 ST8SIA5 CHST9 B4GALT7 ATP4B GLCE	2.52e-04	430	43	6	GO:0009100
Domain	ig	ADAMTSL3 PTPRM SEMA3E	1.07e-02	190	45	3	PF00047
Domain	Immunoglobulin	ADAMTSL3 PTPRM SEMA3E	1.07e-02	190	45	3	IPR013151
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	XYLT1 B4GALT7 GLCE	3.82e-05	26	36	3	M7330
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_LINKAGE_TETRASACCHARIDE	XYLT1 B4GALT7	6.31e-05	5	36	2	M47914
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	XYLT1 B4GALT7 GLCE	1.53e-04	41	36	3	M48095
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	XYLT1 CHST9 B4GALT7	2.44e-04	48	36	3	MM14696
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	XYLT1 CHST9 B4GALT7	2.76e-04	50	36	3	M678
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	XYLT1 CHST9 B4GALT7 GLCE	2.87e-04	126	36	4	M695
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	XYLT1 B4GALT7 GLCE	4.07e-04	57	36	3	M692
Pathway	WP_PATHWAYS_OF_NUCLEIC_ACID_METABOLISM_AND_INNATE_IMMUNE_SENSING	OAS1 ADAR	7.44e-04	16	36	2	M39846
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	XYLT1 PHKB CHST9 B4GALT7 GLCE	7.71e-04	288	36	5	M16864
Pathway	WP_PROTEOGLYCAN_BIOSYNTHESIS	XYLT1 B4GALT7	9.46e-04	18	36	2	M39865
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE	XYLT1 B4GALT7	1.42e-03	22	36	2	M19166
Pubmed	Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition.	BACE1 ADAM10	1.79e-06	2	47	2	37658602
Pubmed	Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.	BACE1 ADAM10	1.79e-06	2	47	2	32019490
Pubmed	ADAM10 and BACE1 are localized to synaptic vesicles.	BACE1 ADAM10	1.79e-06	2	47	2	26296617
Pubmed	Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.	BACE1 ADAM10	1.79e-06	2	47	2	32913125
Pubmed	Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus.	BACE1 ADAM10	1.79e-06	2	47	2	12438920
Pubmed	Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease.	BACE1 ADAM10	1.79e-06	2	47	2	19344981
Pubmed	α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.	BACE1 ADAM10	5.36e-06	3	47	2	29325091
Pubmed	Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.	BACE1 ADAM10	5.36e-06	3	47	2	21576249
Pubmed	Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.	BACE1 ADAM10	5.36e-06	3	47	2	12665519
Pubmed	Visualization of Alzheimer's Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer.	BACE1 ADAM10	5.36e-06	3	47	2	30538620
Pubmed	Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.	BACE1 ADAM10	5.36e-06	3	47	2	22940630
Pubmed	The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.	BACE1 ADAM10	5.36e-06	3	47	2	26497029
Pubmed	Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.	BACE1 ADAM10	5.36e-06	3	47	2	21695060
Pubmed	Vascular endothelial growth factor improves the cognitive decline of Alzheimer's disease via concurrently inducing the expression of ADAM10 and reducing the expression of β-site APP cleaving enzyme 1 in Tg2576 mice.	BACE1 ADAM10	5.36e-06	3	47	2	29702127
Pubmed	Klotho is a substrate for alpha-, beta- and gamma-secretase.	BACE1 ADAM10	1.07e-05	4	47	2	19737556
Pubmed	Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.	TMEM209 TSGA13	1.07e-05	4	47	2	14962666
Pubmed	Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.	BACE1 ADAM10	1.78e-05	5	47	2	11032903
Pubmed	The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.	BACE1 ADAM10	1.78e-05	5	47	2	12354787
Pubmed	Cloning and chromosomal location of human genes inducible by type I interferon.	OAS1 ADAR	2.67e-05	6	47	2	3175763
Pubmed	Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.	ADAM10 IBSP	3.74e-05	7	47	2	31112308
Pubmed	A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.	OAS1 ADAR	4.98e-05	8	47	2	19559055
Pubmed	Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.	ADAM10 ADAR	4.98e-05	8	47	2	19667218
Pubmed	Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study.	OAS1 ADAR	9.75e-05	11	47	2	12447867
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	XYLT1 OAS1 OAT CAT GAK ADAM10 ADAR SF3A1 GLCE	1.21e-04	1451	47	9	30550785
Pubmed	Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.	TMEM209 BPTF GAK B4GALT7 CCDC144A	1.22e-04	359	47	5	35559673
Pubmed	Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.	OAS1 ADAR	1.38e-04	13	47	2	19434718
Pubmed	Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.	BACE1 ADAM10	3.01e-04	19	47	2	31442405
Pubmed	A whole genome screen for HIV restriction factors.	TMEM209 SETDB1 FAM83B	4.27e-04	108	47	3	22082156
Pubmed	Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs.	CCDC144CP CCDC144A	7.09e-04	29	47	2	11997339
Pubmed	Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.	TRAF3IP2 OAT CAT	7.67e-04	132	47	3	22496890
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	JPH1 TMEM209 UQCC2 OAT CAT FAM83B FECH VPS13A	8.10e-04	1496	47	8	32877691
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	PHKB OAT CAT ADAR SF3A1	8.69e-04	551	47	5	34728620
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	JPH1 OAS1 SHISA2 PTPRM FAM83B	1.00e-03	569	47	5	30639242
Pubmed	Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation.	CAT IBSP	1.35e-03	40	47	2	16210410
Cytoband	Ensembl 112 genes in cytogenetic band chr5q35	OR2V1 B4GALT7 OR2V2	1.82e-03	235	47	3	chr5q35
GeneFamily	Immunoglobulin like domain containing	ADAMTSL3 PTPRM SEMA3E	3.57e-03	193	29	3	594
GeneFamily	Olfactory receptors, family 2	OR2V1 OR2V2	1.41e-02	113	29	2	149
Drug	N6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA	SETDB1 CTBS B4GALT7 GLCE CARD8 VPS13A	2.89e-06	199	46	6	959_DN
Disease	pseudoxanthoma elasticum (is_implicated_in)	XYLT1 CAT	8.88e-05	9	47	2	DOID:2738 (is_implicated_in)
Disease	cataract (biomarker_via_orthology)	CAT ADAM10	1.92e-04	13	47	2	DOID:83 (biomarker_via_orthology)
Disease	Strabismus	PHKB ZNF618	9.81e-04	29	47	2	HP_0000486
Disease	respiratory failure, COVID-19	OAS1 PTPRM	9.81e-04	29	47	2	EFO_0009686, MONDO_0100096
Disease	coronary aneurysm	CPNE4 ZNF618	1.43e-03	35	47	2	EFO_1000881
Disease	Mammary Carcinoma, Human	TRERF1 CAT ADAM10 ADAR IBSP	1.45e-03	525	47	5	C4704874
Disease	Mammary Neoplasms, Human	TRERF1 CAT ADAM10 ADAR IBSP	1.45e-03	525	47	5	C1257931
Disease	Mammary Neoplasms	TRERF1 CAT ADAM10 ADAR IBSP	1.47e-03	527	47	5	C1458155

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLAAGQHDLVPHYYV	BARGIN	651	Q6ZT62
VYNYHLSPRAFLHYP	ERF	321	P50548
VGAAPHPFLHRYYQR	BACE1	101	P56817
FAYPDTHRHRLGPNY	CAT	356	P04040
YHEDDINYPHKYGPQ	ADAM10	156	O14672
HSYSKVYAQRAPYHP	GLCE	156	O94923
FPHYYIKPYHLKRIH	ANKRD36B	11	Q8N2N9
EPSLKNIIHSYYHPY	CCDC144CP	316	Q8IYA2
QRAPYYNYKDPAGHF	CTBS	311	Q01459
SLHYFPYYGKKAQPH	ATP4B	226	P51164
HHVLPYQEAEDYPYG	BPTF	341	Q12830
VLHEGFHFPYDYPNL	ENTPD7	486	Q9NQZ7
LHSQYHGYYVKLNAP	JPH1	546	Q9HDC5
ASPELHPLYHYKTYV	B4GALT7	186	Q9UBV7
YNIRSHGYKPHFVPN	FAM83B	351	Q5T0W9
YDRYVAVSHPLHYPI	OR2V1	121	Q8NHB1
YDRYVAISHPLHYPI	OR2V2	121	Q96R30
RYQKYGYIGTHEYPH	OAS1	361	P00973
VHPFTYRGLPKHTYA	F2RL2	196	O00254
HPGHYAVYNLSPRTY	GAK	446	O14976
YYNEKYGGPNHHLPL	CPN1	171	P15169
GYYTHPFQGYEHRQL	ADAR	11	P55265
SLHYIHPYQPNEYLK	CPNE4	326	Q96A23
IYYHPHPEDIKFHLY	CARD8	321	Q9Y2G2
EPSLKNIIHPYYHPY	CCDC144B	366	Q3MJ40
SPNTAPHKYYIGFRY	FECH	151	P22830
PHKYYIGFRYVHPLT	FECH	156	P22830
EPSLKNIIHPYYHPY	CCDC144A	366	A2RUR9
HYFSKHPQRGYLPVQ	DRP2	681	Q13474
LHHTTEGYPVVPKYY	PHKB	396	Q93100
GNYIDGYHRPNHYIA	PTPRM	956	P28827
NPYDLHPVREGHCYK	GAREM2	276	Q75VX8
LYITHHYYDNVKPRP	ST8SIA5	331	O15466
YKHAYFYPHLKRFPV	IBSP	46	P21815
QYLHPPYVGYTVQHD	SHISA2	241	Q6UWI4
PNDPYHAYYRHKVSE	SF3A1	86	Q15459
REYKYGAHNYHPLPV	OAT	46	P04181
HIAYDYHPPADKLYV	SETDB1	246	Q15047
DHQVPYGHDYPRAAY	TRAF3IP2	281	O43734
HPNSYYHPVFGKAII	CHST9	296	Q7L1S5
HYTVHPNLAQYYKPL	TSGA13	51	Q96PP4
RYYPMGHPASVHLYF	XYLT1	676	Q86Y38
KYYTPYQEHVALHAP	ZNF618	266	Q5T7W0
QYKADGIHRKHPPNY	VPS13A	2226	Q96RL7
ARLHSNYYKHKYPRP	UQCC2	61	Q9BRT2
INPPHYELIYQRHVY	TMEM209	501	Q96SK2
PYAHKEGPEYHWSVY	SEMA3E	356	O15041
HLAHYVPKIYCRGPN	UBR2	41	Q8IWV8
HPTQGHLYYDYQQPL	TRERF1	226	Q96PN7
LKRVVPDHYCHYYPE	ADAMTSL3	371	P82987
PDHYCHYYPENVKPK	ADAMTSL3	376	P82987