Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5D16 OR51T1 VN1R5 OR5T3 OR5AC1 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 TAS2R38 ADGRE2 OR2L13 OR10G7 OR10G4 OR2T8 ELOVL4 OR4F5 SPHK1 OR5H8 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 LGR6 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	3.13e-12	884	180	33	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H8 OR5H6 OR2Y1 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	5.54e-11	431	180	22	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR5D16 OR51T1 VN1R5 OR5T3 OR5AC1 HTR2C OR2T33 OR5D14 ROR1 OR4F4 NTSR1 HTR3E LGR4 OR2T12 ACVR1 TAS2R38 ADGRE2 OR2L13 OR10G7 OR10G4 OR2T8 ELOVL4 OR4F5 SPHK1 TLR1 OR5H8 TLR3 PKD1 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 LGR6 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	6.77e-11	1353	180	39	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR5D16 OR5T3 OR5AC1 OR5D14 LCN1 OR5H8 OR5H6 OR5D13	2.01e-05	127	180	8	GO:0005549
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	ERN1 RPS6KB2 ADCK1 STK38 SIK1 ACVR1 PKMYT1 PHKA1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	5.52e-05	446	180	14	GO:0004674
GeneOntologyMolecularFunction	valine-tRNA ligase activity	VARS2 VARS1	8.08e-05	2	180	2	GO:0004832
GeneOntologyMolecularFunction	metalloendopeptidase activity	OMA1 MMP24 ADAMTS17 MMP3 MMP10 MMP12 MMP26	1.09e-04	120	180	7	GO:0004222
GeneOntologyMolecularFunction	aminoacyl-tRNA editing activity	VARS2 AARSD1 VARS1	2.44e-04	14	180	3	GO:0002161
GeneOntologyMolecularFunction	protein kinase activity	ERN1 RPS6KB2 ROR1 ADCK1 STK38 SIK1 ACVR1 PKMYT1 PHKA1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	3.65e-04	600	180	15	GO:0004672
GeneOntologyMolecularFunction	microfilament motor activity	MYO1G MYO1C MYO9A MYO3B	3.71e-04	38	180	4	GO:0000146
GeneOntologyMolecularFunction	protein serine kinase activity	ERN1 RPS6KB2 STK38 SIK1 PKMYT1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	4.72e-04	363	180	11	GO:0106310
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO1G MYO1C MYO9A KIF20A MYO3B DNAH6	7.06e-04	118	180	6	GO:0003774
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ERN1 RPS6KB2 ROR1 ADCK1 STK38 SIK1 ACVR1 PKMYT1 PHKA1 TNNI3K MAST4 SPHK1 MYO3B ULK4 RPS6KL1 MOS	7.10e-04	709	180	16	GO:0016773
GeneOntologyBiologicalProcess	sensory perception	OR5D16 OR51T1 CACNA1F VN1R5 OR5T3 OR5AC1 OR2T33 MYO9A OR5D14 ROR1 OR4F4 NTSR1 SLC26A5 EML2 OR2T12 LCN1 TAS2R38 OR2L13 ABCC6 OR10G7 OR10G4 OR2T8 OR4F5 MMP24 LRIG1 TMTC4 MYO3B OR5H8 OR5H6 OR2Y1 TAS1R2 CLN6 OR1P1 OR4F17 ULK4 NLGN2 OR10G9 OR10G8 OR56B4 OR5D13	4.22e-15	1072	181	40	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR5D16 OR51T1 CACNA1F OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 NTSR1 OR2T12 TAS2R38 OR2L13 OR10G7 OR10G4 PITPNM1 OR2T8 ELOVL4 OR4F5 MMP24 JUP TLR1 OR5H8 PKD1 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 C4B OR10G9 OR10G8 OR56B4 OR5D13	5.43e-15	722	181	33	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 TAS2R38 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 TLR1 OR5H8 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 C4B OR10G9 OR10G8 OR56B4 OR5D13	8.89e-13	524	181	26	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR5D16 OR51T1 CACNA1F OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 NTSR1 OR2T12 TAS2R38 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 MMP24 OR5H8 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	1.50e-12	582	181	27	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR5D16 OR51T1 VN1R5 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 LCN1 TAS2R38 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H8 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	2.35e-12	547	181	26	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 TAS2R38 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H8 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	7.65e-12	485	181	24	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H8 OR5H6 OR2Y1 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	3.51e-11	432	181	22	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H8 OR5H6 OR2Y1 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	1.44e-10	465	181	22	GO:0007608
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR5D16 OR51T1 VN1R5 OR5T3 OR5AC1 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 TAS2R38 ADGRE2 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 SPHK1 OR5H8 OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 LGR6 CCL17 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	1.58e-07	1395	181	33	GO:0007186
GeneOntologyBiologicalProcess	positive regulation of inhibitory postsynaptic potential	NTSR1 NLGN3 NLGN2	7.62e-05	10	181	3	GO:0097151
GeneOntologyBiologicalProcess	valyl-tRNA aminoacylation	VARS2 VARS1	7.66e-05	2	181	2	GO:0006438
GeneOntologyBiologicalProcess	collagen catabolic process	MMP24 MMP3 MMP10 MMP12 MMP26	1.00e-04	53	181	5	GO:0030574
GeneOntologyBiologicalProcess	modulation of inhibitory postsynaptic potential	NTSR1 NLGN3 NLGN2	1.38e-04	12	181	3	GO:0098828
GeneOntologyBiologicalProcess	aminoacyl-tRNA metabolism involved in translational fidelity	VARS2 AARSD1 VARS1	1.78e-04	13	181	3	GO:0106074
Domain	Olfact_rcpt	OR5D16 OR51T1 OR5T3 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	6.05e-09	393	176	19	IPR000725
Domain	G_PROTEIN_RECEP_F1_1	OR5D16 OR51T1 VN1R5 OR5T3 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 LGR6 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	6.69e-09	685	176	25	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5D16 OR51T1 VN1R5 OR5T3 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 LGR6 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	7.96e-09	691	176	25	PS50262
Domain	GPCR_Rhodpsn	OR5D16 OR51T1 VN1R5 OR5T3 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 LGR6 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	8.19e-09	692	176	25	IPR000276
Domain	7tm_1	OR5D16 OR51T1 OR5T3 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 LGR6 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	2.41e-08	677	176	24	PF00001
Domain	GPCR_Rhodpsn_7TM	OR5D16 OR51T1 OR5T3 HTR2C OR2T33 OR5D14 OR4F4 NTSR1 LGR4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 OR10G9 OR10G8 OR56B4 PTGDR2 OR5D13	8.67e-08	670	176	23	IPR017452
Domain	M10A_MMP	MMP24 MMP3 MMP10 MMP12 MMP26	2.06e-06	23	176	5	IPR033739
Domain	Pept_M10A	MMP24 MMP3 MMP10 MMP12 MMP26	2.06e-06	23	176	5	IPR021190
Domain	CYSTEINE_SWITCH	MMP24 ADAMTS17 MMP3 MMP10 MMP12 MMP26	2.20e-06	41	176	6	PS00546
Domain	Peptidase_M10	MMP24 MMP3 MMP10 MMP12 MMP26	2.58e-06	24	176	5	PF00413
Domain	Pept_M10_metallopeptidase	MMP24 ADAMTS17 MMP3 MMP10 MMP12 MMP26	2.94e-06	43	176	6	IPR001818
Domain	ARM-type_fold	MYBBP1A NBEAL1 SARM1 USP24 ARMC2 SDAD1 RSPRY1 JUP NOP9 PPP2R5E NOM1 ARID2 ULK4 WDFY3	4.22e-06	339	176	14	IPR016024
Domain	Peptidase_Metallo	MMP24 MMP3 MMP10 MMP12 MMP26	6.94e-06	29	176	5	IPR006026
Domain	ZnMc	MMP24 MMP3 MMP10 MMP12 MMP26	6.94e-06	29	176	5	SM00235
Domain	Hemopexin_CS	MMP24 MMP3 MMP10 MMP12	1.65e-05	17	176	4	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP24 MMP3 MMP10 MMP12	2.10e-05	18	176	4	IPR016293
Domain	PG_binding_1	MMP24 MMP3 MMP10 MMP12	3.28e-05	20	176	4	PF01471
Domain	Peptidoglycan-bd-like	MMP24 MMP3 MMP10 MMP12	3.28e-05	20	176	4	IPR002477
Domain	ZINC_PROTEASE	OMA1 MMP24 ADAMTS17 MMP3 MMP10 MMP12 MMP26	3.94e-05	98	176	7	PS00142
Domain	Hemopexin-like_dom	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	IPR000585
Domain	Hemopexin-like_repeat	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	IPR018487
Domain	HEMOPEXIN	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	PS00024
Domain	-	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	2.110.10.10
Domain	HEMOPEXIN_2	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	PS51642
Domain	HX	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	SM00120
Domain	Hemopexin	MMP24 MMP3 MMP10 MMP12	5.87e-05	23	176	4	PF00045
Domain	Valyl-tRNA_ligase	VARS2 VARS1	8.83e-05	2	176	2	IPR002303
Domain	Anticodon_Ia_Val	VARS2 VARS1	8.83e-05	2	176	2	IPR033705
Domain	-	MMP24 ADAMTS17 MMP3 MMP10 MMP12 MMP26	1.16e-04	81	176	6	3.40.390.10
Domain	MetalloPept_cat_dom	MMP24 ADAMTS17 MMP3 MMP10 MMP12 MMP26	1.16e-04	81	176	6	IPR024079
Domain	PROTEIN_KINASE_ATP	ERN1 RPS6KB2 ROR1 ADCK1 STK38 SIK1 ACVR1 PKMYT1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	1.19e-04	459	176	14	PS00107
Domain	LRRNT	LRRC32 LGR4 LRIG1 PKD1 LGR6	1.40e-04	53	176	5	PF01462
Domain	PROTEIN_KINASE_ST	ERN1 RPS6KB2 STK38 SIK1 ACVR1 PKMYT1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	1.71e-04	362	176	12	PS00108
Domain	LRR_8	LRRC32 LGR4 LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6	2.21e-04	171	176	8	PF13855
Domain	Prot_kinase_dom	ERN1 RPS6KB2 ROR1 ADCK1 STK38 SIK1 ACVR1 PKMYT1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	2.28e-04	489	176	14	IPR000719
Domain	PROTEIN_KINASE_DOM	ERN1 RPS6KB2 ROR1 ADCK1 STK38 SIK1 ACVR1 PKMYT1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	2.48e-04	493	176	14	PS50011
Domain	LRR_TYP	LRRC32 LGR4 LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6	2.80e-04	177	176	8	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRRC32 LGR4 LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6	2.80e-04	177	176	8	IPR003591
Domain	LRRNT	LRRC32 LGR4 LRIG1 TLR3 PKD1 LGR6	3.31e-04	98	176	6	IPR000372
Domain	LRRNT	LRRC32 LGR4 LRIG1 TLR3 PKD1 LGR6	3.31e-04	98	176	6	SM00013
Domain	Pept_M10A_Zn_BS	MMP3 MMP10 MMP12	3.44e-04	15	176	3	IPR021158
Domain	Myosin_head_motor_dom	MYO1G MYO1C MYO9A MYO3B	4.38e-04	38	176	4	IPR001609
Domain	MYOSIN_MOTOR	MYO1G MYO1C MYO9A MYO3B	4.38e-04	38	176	4	PS51456
Domain	Myosin_head	MYO1G MYO1C MYO9A MYO3B	4.38e-04	38	176	4	PF00063
Domain	MYSc	MYO1G MYO1C MYO9A MYO3B	4.38e-04	38	176	4	SM00242
Domain	DUF1736	TMTC2 TMTC4	5.23e-04	4	176	2	IPR013618
Domain	DUF1736	TMTC2 TMTC4	5.23e-04	4	176	2	PF08409
Domain	Ser/Thr_kinase_AS	ERN1 RPS6KB2 STK38 SIK1 ACVR1 PKMYT1 TNNI3K MAST4 MYO3B RPS6KL1 MOS	5.90e-04	357	176	11	IPR008271
Domain	Kinase-like_dom	ERN1 RPS6KB2 ROR1 ADCK1 STK38 SIK1 ACVR1 PKMYT1 TNNI3K MAST4 MYO3B ULK4 RPS6KL1 MOS	6.37e-04	542	176	14	IPR011009
Domain	LRR	LRRC32 LGR4 LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6	6.51e-04	201	176	8	PS51450
Domain	Anaphylatoxin_comp_syst	C4A C4B	8.67e-04	5	176	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	8.67e-04	5	176	2	IPR001840
Domain	Nlgn	NLGN3 NLGN2	8.67e-04	5	176	2	IPR000460
Domain	DUF4704	NBEAL1 WDFY3	8.67e-04	5	176	2	IPR031570
Domain	DUF4704	NBEAL1 WDFY3	8.67e-04	5	176	2	PF15787
Domain	-	LRRC32 LGR4 LRRC14B LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6 NLRP5	9.60e-04	321	176	10	3.80.10.10
Domain	TIR	SARM1 TLR1 TLR3	9.66e-04	21	176	3	SM00255
Domain	Pkinase	ERN1 RPS6KB2 STK38 SIK1 ACVR1 PKMYT1 MAST4 MYO3B ULK4 RPS6KL1 MOS	1.00e-03	381	176	11	PF00069
Domain	ARM-like	SARM1 ARMC2 RSPRY1 JUP NOP9 PPP2R5E ARID2 ULK4 WDFY3	1.07e-03	270	176	9	IPR011989
Domain	Leu-rich_rpt	LRRC32 LGR4 LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6 NLRP5	1.10e-03	271	176	9	IPR001611
Domain	Quino_amine_DH_bsu	TEP1 NBAS WDR6	1.11e-03	22	176	3	IPR011044
Domain	L_dom-like	LRRC32 LGR4 LRRC14B LRIG1 LRRC53 TLR1 TLR3 PKD1 LGR6 NLRP5	1.13e-03	328	176	10	IPR032675
Domain	-	SARM1 TLR1 TLR3	1.27e-03	23	176	3	3.40.50.10140
Domain	PQQ	ERN1 ZNF106	1.29e-03	6	176	2	SM00564
Domain	PH_BEACH	NBEAL1 WDFY3	1.29e-03	6	176	2	PF14844
Domain	Gphrmn_rcpt_fam	LGR4 LGR6	1.29e-03	6	176	2	IPR002131
Domain	PQQ_repeat	ERN1 ZNF106	1.29e-03	6	176	2	IPR002372
Domain	Val/Leu/Ile-tRNA-synth_edit	VARS2 VARS1	1.29e-03	6	176	2	IPR009008
Domain	PQQ_beta_propeller_repeat	ERN1 ZNF106	1.29e-03	6	176	2	IPR018391
Domain	Anticodon_1	VARS2 VARS1	1.29e-03	6	176	2	PF08264
Domain	M/V/L/I-tRNA-synth_anticd-bd	VARS2 VARS1	1.29e-03	6	176	2	IPR013155
Domain	-	VARS2 VARS1	1.29e-03	6	176	2	3.90.740.10
Domain	TIR	SARM1 TLR1 TLR3	1.44e-03	24	176	3	PS50104
Domain	Quinoprotein_ADH-like_supfam	ERN1 EML2 FBXW2 WDR6	1.56e-03	53	176	4	IPR011047
Domain	TIR_dom	SARM1 TLR1 TLR3	1.62e-03	25	176	3	IPR000157
Domain	PAS	NPAS3 HIF3A PDE8B	1.62e-03	25	176	3	PF00989
Domain	PAS_fold	NPAS3 HIF3A PDE8B	1.62e-03	25	176	3	IPR013767
Domain	aa-tRNA-synth_Ia	VARS2 VARS1	1.80e-03	7	176	2	IPR002300
Domain	ANATO	C4A C4B	1.80e-03	7	176	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	1.80e-03	7	176	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.80e-03	7	176	2	PS01177
Domain	tRNA-synt_1	VARS2 VARS1	1.80e-03	7	176	2	PF00133
Domain	ANATO	C4A C4B	1.80e-03	7	176	2	PF01821
Domain	Myosin_TH1	MYO1G MYO1C	1.80e-03	7	176	2	PF06017
Domain	Myosin_TH1	MYO1G MYO1C	1.80e-03	7	176	2	IPR010926
Domain	TH1	MYO1G MYO1C	1.80e-03	7	176	2	PS51757
Domain	Anaphylatoxin/fibulin	C4A C4B	1.80e-03	7	176	2	IPR000020
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	2.38e-03	8	176	2	IPR019565
Domain	PH-BEACH_dom	NBEAL1 WDFY3	2.38e-03	8	176	2	IPR023362
Domain	-	NBEAL1 WDFY3	2.38e-03	8	176	2	2.30.29.40
Domain	Thiol-ester_cl	C4A C4B	2.38e-03	8	176	2	PF10569
Domain	PH_BEACH	NBEAL1 WDFY3	2.38e-03	8	176	2	PS51783
Domain	MacrogloblnA2_CS	C4A C4B	2.38e-03	8	176	2	IPR019742
Domain	BEACH	NBEAL1 WDFY3	3.04e-03	9	176	2	PS50197
Domain	Beach	NBEAL1 WDFY3	3.04e-03	9	176	2	PF02138
Domain	-	NBEAL1 WDFY3	3.04e-03	9	176	2	1.10.1540.10
Domain	Beach	NBEAL1 WDFY3	3.04e-03	9	176	2	SM01026
Domain	BEACH_dom	NBEAL1 WDFY3	3.04e-03	9	176	2	IPR000409
Domain	LRRCT	LRIG1 TLR1 TLR3	3.34e-03	32	176	3	PF01463
Domain	PAS	NPAS3 HIF3A PDE8B	3.34e-03	32	176	3	SM00091
Pathway	REACTOME_SENSORY_PERCEPTION	OR5D16 OR51T1 TRPM4 OR5T3 OR5AC1 OR2T33 MYO1C OR5D14 OR4F4 SLC26A5 OR2T12 TAS2R38 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 MYO3B OR5H6 OR2Y1 TAS1R2 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	6.06e-11	636	136	27	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR1P1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	5.06e-10	417	136	21	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR5D16 OR51T1 OR5T3 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR4F5 OR5H6 OR2Y1 OR4F17 OR10G9 OR10G8 OR56B4 OR5D13	6.05e-09	389	136	19	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5D14 OR4F4 OR2L13 OR10G7 OR10G4 OR10G9 OR10G8	4.81e-06	70	136	7	MM14984
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP24 MMP3 MMP10 MMP12 MMP26	9.11e-06	30	136	5	M39652
Pathway	REACTOME_SENSORY_PERCEPTION	OR5D14 OR4F4 TAS2R38 OR2L13 OR10G7 OR10G4 TAS1R2 OR10G9 OR10G8	9.33e-05	190	136	9	MM15687
Pathway	WP_GPCRS_ODORANT	VN1R5 LGR4 TAS2R38 OR5H6 OR2Y1 TAS1R2 LGR6 PTGDR2	1.40e-04	157	136	8	MM15872
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP24 MMP3 MMP10 MMP12	1.63e-04	29	136	4	MM15981
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR5H8 OR5H6 OR2Y1 OR1P1 OR10G9 OR10G8 OR56B4 OR5D13	2.27e-15	343	182	20	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR5H8 OR5H6 OR2Y1 OR1P1 OR10G9 OR10G8 OR56B4 OR5D13	2.68e-15	346	182	20	14611657
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR5H8 OR5H6 OR2Y1 OR1P1 OR10G9 OR10G8 OR56B4	2.53e-14	340	182	19	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR2L13 OR10G7 OR10G4 OR2T8 OR5H8 OR5H6 OR2Y1 OR1P1 OR10G9 OR10G8 OR56B4	2.53e-14	340	182	19	11802173
Pubmed	The human olfactory receptor gene family.	OR5D16 OR51T1 OR5T3 OR5AC1 OR2T33 OR5D14 OR4F4 OR2T12 OR10G7 OR10G4 OR5H8 OR5H6 OR2Y1 OR1P1 OR10G9 OR10G8 OR56B4 OR5D13	6.43e-10	541	182	18	14983052
Pubmed	Matrix metalloproteinases.	MMP24 MMP3 MMP10 MMP12 MMP26	9.10e-08	22	182	5	10419448
Pubmed	Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture.	MMP3 MMP10 MMP12	5.62e-07	4	182	3	21410539
Pubmed	Matrix metalloproteinases in tumor invasion.	MMP24 MMP3 MMP10 MMP12	1.26e-06	16	182	4	10949577
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP3 MMP10 MMP12	4.86e-06	7	182	3	8921407
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP3 MMP10 MMP12	4.86e-06	7	182	3	11113146
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP24 MMP3 MMP10 MMP12	4.93e-06	22	182	4	23421805
Pubmed	Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.	MMP24 MMP3 MMP10 MMP12	7.10e-06	24	182	4	15734845
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF473 SARM1 VARS2 RSPRY1 NLGN3 ZBTB39 ARID2 EEPD1 TLR1 NCEH1 NLGN2 PRMT7	1.25e-05	493	182	12	15368895
Pubmed	Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.	LGR4 LRIG1 LGR6	2.26e-05	11	182	3	20223988
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.72e-05	2	182	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.72e-05	2	182	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.72e-05	2	182	2	15998580
Pubmed	The structure and expression of the human neuroligin-3 gene.	NLGN3 NLGN2	2.72e-05	2	182	2	10767552
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.72e-05	2	182	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.72e-05	2	182	2	19933335
Pubmed	Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.	TAS2R38 TAS1R2	2.72e-05	2	182	2	35510485
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.72e-05	2	182	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.72e-05	2	182	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.72e-05	2	182	2	12207352
Pubmed	Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.	NLGN3 NLGN2	2.72e-05	2	182	2	27805570
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.72e-05	2	182	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	2.72e-05	2	182	2	22387014
Pubmed	Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma.	MMP3 MMP10	2.72e-05	2	182	2	36231910
Pubmed	Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression.	ERN1 SPHK1	2.72e-05	2	182	2	26240153
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	2.72e-05	2	182	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	2.72e-05	2	182	2	23918728
Pubmed	An integrated PKD1-dependent signaling network amplifies IRE1 prosurvival signaling.	ERN1 PKD1	2.72e-05	2	182	2	31167779
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.72e-05	2	182	2	3037333
Pubmed	LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.	STAT3 LRIG1	2.72e-05	2	182	2	24316976
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.72e-05	2	182	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.72e-05	2	182	2	4216347
Pubmed	STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis.	STAT3 MMP3	2.72e-05	2	182	2	23967200
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	2.72e-05	2	182	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	2.72e-05	2	182	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	2.72e-05	2	182	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	2.72e-05	2	182	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	2.72e-05	2	182	2	21345967
Pubmed	Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.	MMP3 MMP10	2.72e-05	2	182	2	2605216
Pubmed	Matrix metalloproteinases contribute to the regulation of chemokine expression and pulmonary inflammation in Cryptococcus infection.	MMP3 MMP12	2.72e-05	2	182	2	26445891
Pubmed	The role of DNA hypomethylation in the control of stromelysin gene expression.	MMP3 MMP10	2.72e-05	2	182	2	16516860
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	2.72e-05	2	182	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	2.72e-05	2	182	2	2302180
Pubmed	Early elevation of serum MMP-3 and MMP-12 predicts protection from World Trade Center-lung injury in New York City Firefighters: a nested case-control study.	MMP3 MMP12	2.72e-05	2	182	2	24146820
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	2.72e-05	2	182	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	2.72e-05	2	182	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	2.72e-05	2	182	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	2.72e-05	2	182	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.72e-05	2	182	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.72e-05	2	182	2	17728371
Pubmed	Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud's arthropathy and a distinctive MRI pattern.	MMP3 MMP12	2.72e-05	2	182	2	33404658
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.72e-05	2	182	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.72e-05	2	182	2	6149581
Pubmed	Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes.	MMP3 MMP12	2.72e-05	2	182	2	21277817
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	2.72e-05	2	182	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.72e-05	2	182	2	3542363
Pubmed	STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1.	POU2F1 STAT3	2.72e-05	2	182	2	23172665
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.72e-05	2	182	2	2387317
Pubmed	Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-α and bradykinin in human colonic myofibroblasts.	PKD1 MMP3	2.72e-05	2	182	2	21867693
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	2.72e-05	2	182	2	16908004
Pubmed	Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.	ROR1 STAT3	2.72e-05	2	182	2	20686606
Pubmed	How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes.	ABCC6 PKD1	2.72e-05	2	182	2	18791038
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.72e-05	2	182	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	2.72e-05	2	182	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.72e-05	2	182	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	2.72e-05	2	182	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.72e-05	2	182	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	2.72e-05	2	182	2	6881182
Pubmed	STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.	IL15 STAT3	2.72e-05	2	182	2	25582338
Pubmed	Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.	NLGN3 NLGN2	2.72e-05	2	182	2	36479216
Pubmed	Association of the polymorphisms in Th2 chemotaxis-related genes with the development and prognosis of autoimmune thyroid diseases.	CCL17 PTGDR2	2.72e-05	2	182	2	29848886
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	2.72e-05	2	182	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	2.72e-05	2	182	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	2.72e-05	2	182	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	2.72e-05	2	182	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	2.72e-05	2	182	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	2.72e-05	2	182	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	2.72e-05	2	182	2	6832377
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	2.72e-05	2	182	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	2.72e-05	2	182	2	11689483
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	2.72e-05	2	182	2	3794341
Pubmed	Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes.	STAT3 TLR3	2.72e-05	2	182	2	24708416
Pubmed	SphK1 promotes development of non‑small cell lung cancer through activation of STAT3.	STAT3 SPHK1	2.72e-05	2	182	2	33236138
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	2.72e-05	2	182	2	22785613
Pubmed	Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease.	RPS6KB2 GAA	2.72e-05	2	182	2	23457523
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	2.72e-05	2	182	2	32691186
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	2.72e-05	2	182	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	2.72e-05	2	182	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.72e-05	2	182	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	2.72e-05	2	182	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.72e-05	2	182	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.72e-05	2	182	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.72e-05	2	182	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.72e-05	2	182	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	2.72e-05	2	182	2	6559257
Pubmed	ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.	ROR1 STAT3	2.72e-05	2	182	2	37343369
Cytoband	1q44	VN1R5 OR2T33 OR2T12 OR2L13 OR2T8	8.10e-05	110	182	5	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	VN1R5 OR2T33 OR2T12 OR2L13 OR2T8	1.65e-04	128	182	5	chr1q44
Cytoband	11q22.3	MMP3 MMP10 MMP12	7.20e-04	44	182	3	11q22.3
Cytoband	11q11	OR5D16 OR5D14 OR5D13	8.74e-04	47	182	3	11q11
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR10G7 OR10G4 OR10G9 OR10G8 VSIG10L2	1.03e-03	191	182	5	chr11q24
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5AC1 OR5H8 OR5H6	1.31e-03	54	182	3	chr3q11
Cytoband	9q34	SH3GLB2 FBXW2 LCN1	1.31e-03	54	182	3	9q34
Cytoband	19q13.1	ZNF146 CYP2S1 KCNK6	1.38e-03	55	182	3	19q13.1
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP24 MMP3 MMP10 MMP12 MMP26	7.04e-07	24	131	5	891
GeneFamily	Olfactory receptors, family 5	OR5D16 OR5T3 OR5AC1 OR5D14 OR5H8 OR5H6 OR5D13	1.72e-05	112	131	7	152
GeneFamily	Olfactory receptors, family 10	OR10G7 OR10G4 OR10G9 OR10G8	1.34e-03	66	131	4	157
GeneFamily	Olfactory receptors, family 2	OR2T33 OR2T12 OR2L13 OR2T8 OR2Y1	1.39e-03	113	131	5	149
GeneFamily	Myosins, class I	MYO1G MYO1C	1.42e-03	8	131	2	1097
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.81e-03	9	131	2	1234
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 WDFY3	1.81e-03	9	131	2	1230
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR3	2.26e-03	10	131	2	948
GeneFamily	ATP binding cassette subfamily C	ABCC11 ABCC6	3.86e-03	13	131	2	807
Disease	matrix metalloproteinase measurement, Alzheimer disease, Alzheimer's disease biomarker measurement	MMP3 MMP12	3.30e-05	2	170	2	EFO_0004744, EFO_0006514, MONDO_0004975
Disease	combined oxidative phosphorylation deficiency 20 (implicated_via_orthology)	VARS2 VARS1	3.30e-05	2	170	2	DOID:0111478 (implicated_via_orthology)
Disease	level of stromelysin-1 in blood serum	MMP3 MMP12	3.30e-05	2	170	2	OBA_2042390
Disease	renal cell carcinoma (is_implicated_in)	STAT3 JUP C4A C4B MMP3	4.99e-05	69	170	5	DOID:4450 (is_implicated_in)
Disease	Connective Tissue Diseases	ACVR1 ZNF469 PKD1	5.15e-05	13	170	3	C0009782
Disease	autism spectrum disorder (implicated_via_orthology)	NDST1 HTR2C NRCAM NLGN3 NLGN2 WDFY3	2.59e-04	152	170	6	DOID:0060041 (implicated_via_orthology)
Disease	cortical surface area measurement	DHX16 OMA1 NBEAL1 PODXL ROR1 RDH14 NPAS3 EML2 ELAC2 PKMYT1 COL24A1 ZNF106 ZNF469 PPP2R5E MAST4 LRIG1 PKD1 C6orf47 RPS6KL1	2.91e-04	1345	170	19	EFO_0010736
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	VARS2 VARS1	6.80e-04	7	170	2	DOID:0060475 (implicated_via_orthology)
Disease	crescentic glomerulonephritis (biomarker_via_orthology)	MMP3 MMP12	9.03e-04	8	170	2	DOID:13139 (biomarker_via_orthology)
Disease	mitochondrial encephalomyopathy (implicated_via_orthology)	VARS2 VARS1	9.03e-04	8	170	2	DOID:890 (implicated_via_orthology)
Disease	aspergillosis (is_implicated_in)	IL15 TLR1	9.03e-04	8	170	2	DOID:13564 (is_implicated_in)
Disease	calpastatin measurement	SARM1 CPNE1	9.03e-04	8	170	2	EFO_0008065
Disease	coronary aneurysm	TMTC2 COL24A1 MYO3B	1.07e-03	35	170	3	EFO_1000881
Disease	Combined oxidative phosphorylation deficiency	VARS2 ELAC2 ATP5F1A	1.26e-03	37	170	3	cv:C4540031
Disease	Atrophic	STAT3 CLN6	1.44e-03	10	170	2	C0333641
Disease	squamous cell lung carcinoma, family history of lung cancer	MYO1G PODXL NPAS3 NBAS	1.50e-03	85	170	4	EFO_0000708, EFO_0006953
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	SARM1 CPNE1	1.75e-03	11	170	2	EFO_0021862
Disease	Lenticulostriate Disorders	PDE8B XPR1	2.10e-03	12	170	2	C0750951
Disease	Extrapyramidal Disorders	PDE8B XPR1	2.10e-03	12	170	2	C0015371
Disease	Basal Ganglia Diseases	PDE8B XPR1	2.10e-03	12	170	2	C0004782
Disease	matrix metalloproteinase measurement	MMP3 MMP12	2.47e-03	13	170	2	EFO_0004744
Disease	Celiac Disease	IL15 MMP3 MMP12	2.53e-03	47	170	3	C0007570
Disease	fertility measurement	SIK1 NBAS	2.87e-03	14	170	2	EFO_0006923
Disease	Mammary Carcinoma, Human	NRCAM RPS6KB2 ROR1 ACVR1 STAT3 NOP9 SLC10A6 LGR6 MMP3	3.53e-03	525	170	9	C4704874
Disease	Mammary Neoplasms, Human	NRCAM RPS6KB2 ROR1 ACVR1 STAT3 NOP9 SLC10A6 LGR6 MMP3	3.53e-03	525	170	9	C1257931
Disease	Mammary Neoplasms	NRCAM RPS6KB2 ROR1 ACVR1 STAT3 NOP9 SLC10A6 LGR6 MMP3	3.62e-03	527	170	9	C1458155
Disease	focal segmental glomerulosclerosis	KCNK6 DNAH6	3.76e-03	16	170	2	EFO_0004236
Disease	Schizoaffective disorder-bipolar type	MYO1G PKMYT1	3.76e-03	16	170	2	EFO_0009965
Disease	neutrophil collagenase measurement	SARM1 CPNE1	3.76e-03	16	170	2	EFO_0008248
Disease	Metastatic melanoma	ROR1 STK38 SIK1	3.76e-03	54	170	3	C0278883
Disease	response to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy	ADCK1 HIF3A LRIG1	3.76e-03	54	170	3	EFO_0000180, EFO_0003100, GO_0061479
Disease	Breast Carcinoma	NRCAM RPS6KB2 ROR1 ACVR1 STAT3 NOP9 SLC10A6 LGR6 MMP3	4.14e-03	538	170	9	C0678222
Disease	complement factor H-related protein 1 measurement	SARM1 MYO3B CPNE1	4.16e-03	56	170	3	EFO_0600054
Disease	Glycogen storage disease	PHKA1 GAA	4.24e-03	17	170	2	cv:C0017919
Disease	plasma beta-amyloid 1-40 measurement	OMA1 NPAS3	4.24e-03	17	170	2	EFO_0005659
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR3	4.24e-03	17	170	2	DOID:8677 (biomarker_via_orthology)
Disease	cancer (implicated_via_orthology)	ACAP1 POLD2 HIF3A PIGZ JUP PPP2R5E	4.72e-03	268	170	6	DOID:162 (implicated_via_orthology)
Disease	matrix metalloproteinase 12 measurement	MMP3 MMP12	4.75e-03	18	170	2	EFO_0010590
Disease	X-11470 measurement	VARS2 VARS1	5.29e-03	19	170	2	EFO_0021241
Disease	Usual Interstitial Pneumonia	STAT3 MMP3	5.29e-03	19	170	2	C4721509
Disease	Hamman-Rich Disease	STAT3 MMP3	5.29e-03	19	170	2	C4721508
Disease	facial asymmetry measurement	ROR1 NPAS3	5.29e-03	19	170	2	EFO_0009751

Protein segments in the cluster

Peptide	Gene	Start	Entry
AIGNPHHVSLAFSIL	URB2	1336	Q14146
LHTVRSLSLFHAQLA	PPP2R5E	271	Q16537
VHIINLSLTFHGQEL	ABCF2	86	Q9UG63
LGTASLAQVHKAVLH	ADCK1	161	Q86TW2
LTAFVTIALHHGLAV	C4B	1141	P0C0L5
GSLLETIFITHLLHV	HTR3E	321	A5X5Y0
LAHLLFLVAIDQTGH	ADGRE2	581	Q9UHX3
LLSLFQTFHQLDLHS	ARMC2	566	Q8NEN0
NAVHSFLVHLIGLLV	HTR2C	6	P28335
LRIVLSIASGLAHLH	ACVR1	306	Q04771
SIASGLAHLHIEIFG	ACVR1	311	Q04771
HSHFISLRQLGLDTL	ARID2	321	Q68CP9
GQHLITAVADHLFKL	AARSD1	111	Q9BTE6
TLLLGASLQHIHAAR	CCL17	11	Q92583
HATILGHTGLACLFL	ACAP1	646	Q15027
HSVLGLSERHVAQFL	DHX16	16	O60231
LHGLLHIFALVIALV	CYB561	86	P49447
GLASQVEAHHSLVLS	DIPK1B	401	Q5VUD6
FNLHLTGDIHAITAA	MTHFD1L	481	Q6UB35
FKVGSHDLTLVNLHL	EEPD1	391	Q7L9B9
LNLAFTIAHELGHNL	ADAMTS17	381	Q8TE56
FLSHVVSQHQALLGT	ATP5F1A	511	P25705
NLFLVATHEIGHSLG	MMP26	201	Q9NRE1
LLAIHLHLVPASSAA	NFE4	86	Q86UQ8
LIHSHGVATLGALLQ	NBEAL1	951	Q6ZS30
NLFLTAVHEIGHSLG	MMP12	211	P39900
IASLHHLAALQGSIS	INTS10	466	Q9NVR2
HLTSITIFHGTILFL	OR5D14	246	Q8NGL3
HLTAITIFHGTILFL	OR5D16	246	Q8NGK9
VLSFIGGFLHALIHE	OR5H8	146	P0DN80
LVLQTFRHVSDLHGL	KCNK6	251	Q9Y257
TLALELHGHLNTLYV	MOB2	166	Q70IA6
FHILAGLTHLAVISN	ANO7	766	Q6IWH7
LFLVAAHELGHSLGL	MMP10	211	P09238
TLIHHHVFTNLILVF	CACNA1F	866	O60840
LFLVAVHELGHALGL	MMP24	276	Q9Y5R2
LTTNVVDIILAHHFG	NDRG3	181	Q9UGV2
LETVFHHVSQAGLEL	PODXL	236	O00592
DVTVLGSLLLQHLLH	NOP9	481	Q86U38
GSLHSAVQTILTFHL	OR10G7	151	Q8NGN6
GSLHSAVQTILTFHL	OR10G4	151	Q8NGN3
ILLGLFNHTRAHQVL	OR2T12	11	Q8NG77
SGSLYGLTALHQLHL	LRIG1	276	Q96JA1
VHYHLGSLALSDLLT	NTSR1	101	P30989
IAKNALGAIHHTISV	NRCAM	341	Q92823
FLEELRLSGNHLSHI	LGR6	91	Q9HBX8
LQLIQFHVTIGHTAL	ELOVL4	221	Q9GZR5
LNSHFLTEAGIHVFI	IL15	21	P40933
SGLHIIHSLDEVNFI	PHKA1	151	P46020
HTFSKLHSLQVLVLS	LRRC53	101	A6NM62
LLVDDSFLHTVAHNG	ASPHD1	341	Q5U4P2
NLFLVAAHEIGHSLG	MMP3	211	P08254
TLHSIIISLVEAGAH	FEM1B	551	Q9UK73
QLLHHVSTLAAFTVR	CYP2S1	236	Q96SQ9
AHVSRVILAGNLLSH	POLD2	236	P49005
ALLETSLLHHFAGFS	PCNX4	366	Q63HM2
ILLGLFNHTRAHQVL	OR2T8	11	A6NH00
ALILGSYVHIAHAVL	OR2Y1	211	Q8NGV0
LLVAINTVSFHGGHE	OR51T1	161	Q8NGJ9
FLHSVSQLAFAVHLL	OR4F5	146	Q8NH21
VSLTFHLFSLHGLIE	PDE7A	171	Q13946
TAVLESHHTALAFQL	PDE8B	681	O95263
SHHLLALNFIIVSFG	NCEH1	56	Q6PIU2
GAFHITIALLHLVFG	MS4A10	61	Q96PG2
HILNSLQGLSSIHVY	ABCC11	1001	Q96J66
AGLHAALHATVVQDL	NDST1	256	P52848
LAVSLGLIAALQAHH	LCN1	6	P31025
GLIAALQAHHLLASD	LCN1	11	P31025
LLHGQFSQAVTPLAH	MANSC1	141	Q9H8J5
AHLEVLDLSGHNLVS	LRRC14B	331	A6NHZ5
AFTNLSSLVVLHLHN	LGR4	196	Q9BXB1
AFHNLSDLHSLVIRG	LGR4	291	Q9BXB1
LAAGVLSAFHHTLQL	IL17D	46	Q8TAD2
IDISFHGILSHINTV	GUCY1B1	261	Q02153
HGILSHINTVFVLRS	GUCY1B1	266	Q02153
QTLTGLHAAFVFHQL	NLRP5	496	P59047
IFAGLLLTSHRHQFH	OTUD7A	636	Q8TE49
GSLHSAVQAILTFHL	OR10G8	151	Q8NGN5
ILLGLFNHTRAHQVL	OR2T33	11	Q8NG76
FLHSVSQLAFAVHLP	OR4F17	146	Q8NGA8
TALSHLVLGVVSLHA	CYHR1	11	Q6ZMK1
RIHVLQILGQSFHLT	NBAS	2106	A2RRP1
IDHAAVLLHGLASLL	PTGDR2	31	Q9Y5Y4
NLSHHREGLLAIFKS	JUP	211	P14923
RAAAFQHLLLLVGIH	MYBBP1A	591	Q9BQG0
AFLGHLHQVQLAGTS	POU2F1	46	P14859
LVLSFIGGLLHALIH	OR5H6	161	Q8NGV6
IGFLHSAIHVGLLFR	OR5AC1	151	P0C628
GAFQALTHLEHLSLA	LRRC32	91	Q14392
FHTGIIVLSVTHLAE	OR56B4	256	Q8NH76
HGFSFHLAAVLLSLA	PORCN	341	Q9H237
LLTLSHHSEGLFQRA	NLGN3	296	Q9NZ94
LYALLSHGEQLVSLH	PATL2	461	C9JE40
FHGLTQNILSHPISI	DNAH6	3431	Q9C0G6
LAFSLLAHVLAAHTA	LACTBL1	181	A8MY62
ALATLHLLFLHETGS	MT-CYB	191	P00156
GLLSFLAALHGLHAV	C6orf47	221	O95873
LAALHGLHAVLSLLT	C6orf47	226	O95873
ITLLQQTTSGLAHLH	ERN1	666	O75460
GSLLSVLAHHLGVEQ	PRMT7	411	Q9NVM4
LATAALLGHILLHDF	GAA	21	P10253
LADGVLSFTHHQIIE	MAST4	406	O15021
GLFHHILVGLLVVAF	FIMP	101	Q96LL3
AAIHVLVTGSLHLVG	FPGS	561	Q05932
LTIALFHVAGKVFIH	SLC44A1	316	Q8WWI5
HTGFSLLVQGHVEEL	EML2	366	O95834
HLISLSGAVQLRHLS	FBXW2	31	Q9UKT8
LAHVGAHSFATENII	CEP295	2151	Q9C0D2
VNLLILSHHSEGLFQ	NLGN2	271	Q8NFZ4
HVVLLHVSSGGQNFI	NTAQ1	81	Q96HA8
LTAFVTIALHHGLAV	C4A	1141	P0C0L4
HDLIGTFHTSLAQLQ	CPNE1	221	Q99829
AGILHATIHIVATFS	OR5T3	181	Q8NGG3
GHLARSLHVLVFVLE	PKD1	1281	P98161
GSLHSAVQTILTFHL	OR10G9	151	Q8NGN4
HLTAITIFHGTILFL	OR5D13	246	Q8NGL4
QFSTLALHLRIHTGK	ZNF146	251	Q15072
VNGLLFLHSQSIVHL	MOS	186	P00540
NLLIVLAIGTDTHLH	OR1P1	56	Q8NH06
GSINSLAHTVFALHI	OR2L13	151	Q8N349
FLHSVSQLAFAVHLP	OR4F4	146	Q96R69
LLHFSIVSVAAHLAL	RTN2	371	O75298
FLHGLLFLSAIQLTH	TAS2R38	66	P59533
VTGSLHLGHALTNAI	VARS1	346	P26640
SLHIGHALTVAIQDA	VARS2	151	Q5ST30
GFLTRELSLVTHALH	VARS2	796	Q5ST30
TVLAIDSIHQLGFIH	STK38	196	Q15208
GQGLLLTLEEHIAHF	RSPRY1	16	Q96DX4
IAFTLALFSHLVNHV	SMG5	381	Q9UPR3
AEITLALGHLHSQGI	RPS6KB2	176	Q9UBS0
LLQGTTRILVTHALH	ABCC6	801	O95255
ILGTSVASHLAELLH	TAF1C	181	Q15572
LLFHSIHDAVLGSQL	SLC26A5	701	P58743
HLGLSQLELIGHSIF	HIF3A	116	Q9Y2N7
RLLLEGISSTHVNHL	SH3GLB2	236	Q9NR46
VASAAQLLDTHLHIG	SIK1B	721	A0A0B4J2F2
VASAAQLLDTHLHIG	SIK1	721	P57059
VTPLLAHLSSAHLAF	SLC17A9	106	Q9BYT1
ATNFSNLVHLVAHLL	NOM1	741	Q5C9Z4
LAIEVFEAHLGSHIL	NPAS3	141	Q8IXF0
FGVNHLGHFLLTNLL	RDH14	161	Q9HBH5
TKILLFAAQASHHLV	SDAD1	351	Q9NVU7
TDIHQLSFLLGHEIA	OMA1	316	Q96E52
LSFLLGHEIAHAVLG	OMA1	321	Q96E52
LHQLHLGVIGSALAN	SLC47A1	206	Q96FL8
HNLFHEGSNSLILIL	TLR1	716	Q15399
SLTFAVLHGHISVVQ	ABTB2	571	Q8N961
VLHGHISVVQLLLDA	ABTB2	576	Q8N961
IHLVGDSVNHRLLFS	CLN6	126	Q9NWW5
FLHLLSSEATHIITI	COL24A1	1606	Q17RW2
SLDHGDFLHIAIQIA	ROR1	586	Q01973
LSHQHLFEIAGFLGI	XPR1	311	Q9UBH6
VHALFLILHSGNILD	PITPNM1	426	O00562
GFHVVNILLHSGISV	TMTC4	106	Q5T4D3
ILAVDGVLSVHSLHI	SLC30A8	291	Q8IWU4
FVSLAHSPLHILNLT	TLR3	401	O15455
SLLNSHILHLTFSLV	WDFY3	1466	Q8IZQ1
LGTLAAVFVSHLHAD	ELAC2	536	Q9BQ52
FLTNLHVVAAHLELG	TEP1	1561	Q99973
HHLGSVILIFSTQGI	STYXL1	236	Q9Y6J8
LASLLKVHLQLHGFS	SARM1	576	Q6SZW1
DTLLALAHLHSQGLV	PKMYT1	216	Q99640
HSIFSIRILHLQGEG	KIF20A	381	O95235
SHATLVFHNLLGEID	STAT3	51	P40763
SYHLVNVLLHAAVTG	TMTC2	86	Q8N394
TATFHLLQAVLLVHL	SERINC4	126	A6NH21
HFFHASTQGILTINI	TMPRSS12	316	Q86WS5
IGHVTGFLLALFTHQ	SLC10A6	236	Q3KNW5
DSIFLHLEHVQGGTL	RPS6KL1	211	Q9Y6S9
THARLTHLAVNGFLL	PIGZ	311	Q86VD9
THLAVNGFLLFGVLH	PIGZ	316	Q86VD9
SGRILQLLAETFHHK	WDR6	896	Q9NNW5
HNLTELRHLGTFLGI	TAS1R2	311	Q8TE23
HNLLVSFAHSIVSGI	TLCD1	46	Q96CP7
SRVTHVLSHIGIFLF	ZBTB39	386	O15060
AHAGLLSHAKTFLLA	ZNF469	786	Q96JG9
EFGNLHNTVALLVLH	USP24	2336	Q9UPU5
HLSLIHILLLFTQAI	VN1R5	86	Q7Z5H4
AHFLQSLTHRLVLGG	TOMM40L	166	Q969M1
DFVLVLALLHSHLGS	SPHK1	256	Q9NYA1
NLAHLQSFLAHLTLT	ZMYND10	306	O75800
ANSLHLHTFDVTFIL	MID2	671	Q9UJV3
QLHAAYSHLTLAVLV	VSIG10L2	131	P0DP72
TALHIATIAGHLEAA	TNNI3K	136	Q59H18
SLIFGVVDHLKQHLL	ZNF106	1821	Q9H2Y7
VQHPLGSQHLSFILS	SIGLEC14	321	Q08ET2
VRLLISHGLSLGHFL	TRPM4	441	Q8TD43
AHVIGLLASHTAELQ	ULK4	531	Q96C45
TLENYSHLVSLGILH	ZNF337	41	Q9Y3M9
GKIFRHSSLLIEHQA	ZNF473	381	Q8WTR7
SIVASVLHLGNIHFA	MYO1C	306	O00159
GFHLLVTVSLLFSHV	SLC8A1	16	P32418
SVHRILAAILHLGNI	MYO1G	271	B0I1T2
AHLIVQHLTFLGKAN	MYO3B	446	Q8WXR4
FLIHHLTALSQKGFA	MYO9A	251	B2RTY4