Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	apical plasma membrane	SLC4A8 SLC13A1 CLCNKA P2RY2 SLCO2B1 SLC20A2 NOX4 SLC3A1	2.18e-04	487	70	8	GO:0016324
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0A2	4.89e-04	10	70	2	GO:0000220
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0A2	7.14e-04	12	70	2	GO:0033179
GeneOntologyCellularComponent	apical part of cell	SLC4A8 SLC13A1 CLCNKA P2RY2 SLCO2B1 SLC20A2 NOX4 SLC3A1	7.96e-04	592	70	8	GO:0045177
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	8.27e-05	4	70	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	8.27e-05	4	70	2	PF08429
Domain	V-type_ATPase_116kDa_su_euka	ATP6V0A1 ATP6V0A2	8.27e-05	4	70	2	IPR026028
Domain	V_ATPase_I	ATP6V0A1 ATP6V0A2	8.27e-05	4	70	2	PF01496
Domain	V-ATPase_116kDa_su	ATP6V0A1 ATP6V0A2	8.27e-05	4	70	2	IPR002490
Domain	zf-C5HC2	KDM5C KDM5D	1.37e-04	5	70	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	1.37e-04	5	70	2	IPR004198
Domain	Znf_FYVE_PHD	PIKFYVE KMT2C KDM5C ZFYVE26 KDM5D	2.26e-04	147	70	5	IPR011011
Domain	JmjN	KDM5C KDM5D	6.11e-04	10	70	2	SM00545
Domain	JMJN	KDM5C KDM5D	6.11e-04	10	70	2	PS51183
Domain	JmjN	KDM5C KDM5D	6.11e-04	10	70	2	PF02375
Domain	JmjN	KDM5C KDM5D	6.11e-04	10	70	2	IPR003349
Domain	-	KDM5C KDM5D	1.41e-03	15	70	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	1.41e-03	15	70	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	1.41e-03	15	70	2	IPR001606
Domain	ARID	KDM5C KDM5D	1.41e-03	15	70	2	PS51011
Domain	ARID	KDM5C KDM5D	1.41e-03	15	70	2	PF01388
Domain	-	PIKFYVE KMT2C TRAF5 KDM5C CHFR ZFYVE26 KDM5D	1.44e-03	449	70	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PIKFYVE KMT2C TRAF5 KDM5C CHFR ZFYVE26 KDM5D	1.63e-03	459	70	7	IPR013083
Domain	PHD	KMT2C KDM5C KDM5D	2.81e-03	75	70	3	PF00628
Domain	Znf_PHD-finger	KMT2C KDM5C KDM5D	3.25e-03	79	70	3	IPR019787
Domain	JmjC	KDM5C KDM5D	3.62e-03	24	70	2	PF02373
Domain	PHD	KMT2C KDM5C KDM5D	4.55e-03	89	70	3	SM00249
Domain	Znf_PHD	KMT2C KDM5C KDM5D	4.84e-03	91	70	3	IPR001965
Domain	FYVE	PIKFYVE ZFYVE26	5.27e-03	29	70	2	PF01363
Domain	FYVE	PIKFYVE ZFYVE26	5.27e-03	29	70	2	SM00064
Domain	ZF_PHD_2	KMT2C KDM5C KDM5D	5.46e-03	95	70	3	PS50016
Domain	ZF_PHD_1	KMT2C KDM5C KDM5D	5.62e-03	96	70	3	PS01359
Domain	JMJC	KDM5C KDM5D	6.39e-03	32	70	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	6.39e-03	32	70	2	IPR003347
Domain	JmjC	KDM5C KDM5D	6.78e-03	33	70	2	SM00558
Domain	Znf_FYVE-rel	PIKFYVE ZFYVE26	7.19e-03	34	70	2	IPR017455
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KMT2C KDM5C KDM5D	2.30e-06	13	71	3	24619213
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	4.11e-06	2	71	2	32081420
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	4.11e-06	2	71	2	9060413
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	4.11e-06	2	71	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	4.11e-06	2	71	2	16416087
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	4.11e-06	2	71	2	7524912
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2C KDM5C KDM5D GTF3C4	5.80e-06	57	71	4	18022353
Pubmed	Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.	ATP6V0A1 ATP6V0A2	1.23e-05	3	71	2	10722719
Pubmed	From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation.	ATP6V0A1 ATP6V0A2	1.23e-05	3	71	2	12672822
Pubmed	Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.	ATP6V0A1 ATP6V0A2	1.23e-05	3	71	2	10702241
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	1.23e-05	3	71	2	7544442
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	2.46e-05	4	71	2	16541399
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	2.46e-05	4	71	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	2.46e-05	4	71	2	7951230
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	2.46e-05	4	71	2	17320160
Pubmed	Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.	ATP6V0A1 ATP6V0A2	2.46e-05	4	71	2	17595521
Pubmed	Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues.	ATP6V0A1 ATP6V0A2	2.46e-05	4	71	2	17497178
Pubmed	The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos.	ATP6V0A1 ATP6V0A2	4.09e-05	5	71	2	35948619
Pubmed	Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.	ATP6V0A1 ATP6V0A2	6.13e-05	6	71	2	21307348
Pubmed	Optic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunit.	ATP6V0A1 ATP6V0A2	8.57e-05	7	71	2	20711468
Pubmed	Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification.	ATP6V0A1 ATP6V0A2	8.57e-05	7	71	2	19549681
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KMT2C KDM5C KDM5D	1.40e-04	49	71	3	34368113
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	3.16e-04	13	71	2	14660691
Pubmed	Structure and Roles of V-type ATPases.	ATP6V0A1 ATP6V0A2	3.16e-04	13	71	2	32001091
Pubmed	A whole genome association study of mother-to-child transmission of HIV in Malawi.	HS3ST3A1 GTF3C4	3.68e-04	14	71	2	20487506
Pubmed	The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.	IRS4 AKAP8L	4.24e-04	15	71	2	25882849
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	KDM5C KDM5D	4.24e-04	15	71	2	14762062
Pubmed	Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.	ATP6V0A1 ATP6V0A2	5.48e-04	17	71	2	33065002
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM5C KDM5D	6.16e-04	18	71	2	12023983
Pubmed	Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.	ATP6V0A1 ATP6V0A2	7.62e-04	20	71	2	22982048
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KDM5C	8.41e-04	21	71	2	27626377
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	ATP6V0A1 ATP6V0A2	9.24e-04	22	71	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	ATP6V0A1 ATP6V0A2	9.24e-04	22	71	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	ATP6V0A1 ATP6V0A2	9.24e-04	22	71	2	14597263
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	ATP6V0A1 ATP6V0A2	9.24e-04	22	71	2	11836511
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	ATP6V0A1 ATP6V0A2	9.24e-04	22	71	2	17662945
Pubmed	Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains.	IRS4 GPR50	1.10e-03	24	71	2	15561968
Pubmed	Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor.	ATP6V0A1 ATP6V0A2	1.20e-03	25	71	2	2874839
Pubmed	CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.	IRS4 DCAF11 AKAP8L	1.43e-03	108	71	3	30166453
Cytoband	3q11.2	OR5K2 OR5K1	7.48e-04	26	71	2	3q11.2
Cytoband	2q34	PIKFYVE IKZF2	8.68e-04	28	71	2	2q34
Cytoband	14q24.1	PIGH ZFYVE26	1.36e-03	35	71	2	14q24.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q34	PIKFYVE IKZF2	2.24e-03	45	71	2	chr2q34
Cytoband	12q24.33	CHFR PUS1	2.54e-03	48	71	2	12q24.33
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5K2 OR5K1	3.20e-03	54	71	2	chr3q11
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	8.97e-04	15	54	2	418
GeneFamily	V-type ATPases	ATP6V0A1 ATP6V0A2	2.13e-03	23	54	2	415
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	2.32e-03	24	54	2	485
GeneFamily	PHD finger proteins	KMT2C KDM5C KDM5D	2.46e-03	90	54	3	88
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	PIKFYVE ZFYVE26	3.85e-03	31	54	2	81
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	IKZF2 GZF1 ZNF705B ZBTB3 ZNF705D ZNF284 ZNF77	5.29e-03	718	54	7	28
GeneFamily	Solute carriers	SLC4A8 SLC13A1 SLCO2B1 SLC20A2 SLC3A1	6.38e-03	395	54	5	752
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SLC4A8 GAS1 CHFR ABLIM2 ZBTB3	4.45e-06	154	70	5	ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSLTR1 KDM5D ZBTB3 F8 GTF3C4	9.76e-06	181	70	5	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSLTR1 KDM5D ZBTB3 F8 GTF3C4	9.76e-06	181	70	5	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 SLCO2B1 INPP5D MED12L PLOD1	1.20e-05	189	70	5	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLA1 CYSLTR1 KDM5C AKAP8L ATP6V0A2	1.20e-05	189	70	5	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 SLCO2B1 INPP5D MED12L PLOD1	1.20e-05	189	70	5	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 SLCO2B1 INPP5D MED12L PLOD1	1.20e-05	189	70	5	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 SLCO2B1 INPP5D MED12L PLOD1	1.20e-05	189	70	5	97ef5215d841ff366a3e3682cd9bd04100cbfde0
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	2.77e-05	4	64	2	DOID:0060809 (implicated_via_orthology)
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	ATP6V0A1 ATP6V0A2	4.61e-05	5	64	2	DOID:0110942 (implicated_via_orthology)
Disease	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	POLA1 KDM5C	1.29e-04	8	64	2	C0796250
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A1 ATP6V0A2	1.29e-04	8	64	2	DOID:14219 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	RAD51C SLCO2B1 PUS1 ZFYVE26 CFHR5 TECTA ZBTB3 PLOD1 DDX10	4.94e-04	1074	64	9	C0006142
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	5.45e-04	16	64	2	DOID:0050888 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	IRS4 KDM5C KDM5D	5.88e-04	75	64	3	DOID:1059 (implicated_via_orthology)
Disease	Kidney Failure	NOX4 CFHR5	1.04e-03	22	64	2	C0035078

Protein segments in the cluster

Peptide	Gene	Start	Entry
CRNQRCVSSSYLGYD	ADAM2	601	Q99965
CEVCFRTFAQRNSLY	GZF1	521	Q9H116
CTLDYQRLYGTRCFS	ABLIM2	71	Q6H8Q1
LTLSRQIDYYCRLDC	ADCY7	811	P51828
RIQFVCSLCKYRTFY	AKAP8L	386	Q9ULX6
FRCRDYTELLAQVYL	RAD51C	211	O43502
RISLYECAVQFYFLC	OR5K2	91	Q8NHB8
SYAALCECLRRVFIY	NUDCD1	506	Q96RS6
CASLSSCPVCYRNYR	KMT2C	1081	Q8NEZ4
YANRRCRYLCSIEEK	KMT2C	4591	Q8NEZ4
RCILAYLYDLYVSCS	MED12L	926	Q86YW9
GRTCLFLQEECCYYL	ERVFC1-1	491	P60608
DLCKCSSSRQYLRYR	KDM5D	726	Q9BY66
RYCYICHSLQYERIF	GPR50	126	Q13585
SFLDYRDLINCCYVS	FBXO3	26	Q9UK99
LLLRYYNEECRNCST	PARG	931	Q86W56
CQDQTIRLYDCRYGR	DCAF11	191	Q8TEB1
YSRVCRSYLCNNLTN	LYPD4	106	Q6UWN0
DSRCNLALSRYLTYC	GAS1	176	P54826
LYVFYCLAERCQTLS	HS3ST3A1	36	Q9Y663
LCLLRFCFSATRRYY	F8	11	P00451
CNICGYRSQDRYEFS	IKZF2	501	Q9UKS7
CKLVRFLFYTNLYCS	P2RY2	106	P41231
QLCFYRYIFDAECAL	POLA1	1391	P09884
LCLYCAERLYRYIRS	NOX4	291	Q9NPH5
YTCCRDGLVRRYQLS	PAAF1	376	Q9BRP4
RISLYECAVQFYFLC	OR5K1	91	Q8NHB7
ADLCRQDRSCTYYFS	PLOD1	366	Q02809
CYRYFTSVLFCHGVR	CFAP119	166	A1A4V9
DLRACTYCRKIALSY	PIKFYVE	206	Q9Y2I7
CYCCGLRSFRELTYQ	CHFR	601	Q96EP1
CYVCLQRAQRNSLLY	CCDC81	326	Q6ZN84
SSLYQLCRLCIRSYI	ASB5	291	Q8WWX0
RYRCSDIFRYRHSVC	CFHR5	356	Q9BXR6
YYFLLDLCCSDILRS	GPR85	56	P60893
AFRTLVRKYSCDLCY	DUS4L	41	O95620
SSCKEVQYLYRVFCR	DDX10	321	Q13206
SFYLLYREIARSCNC	HSDL1	6	Q3SXM5
RAPLSQLYFCRYCSE	DCTN4	21	Q9UJW0
QLYFCRYCSELRSLE	DCTN4	26	Q9UJW0
AEYFNTRYPDCRCLN	SLC13A1	266	Q9BZW2
RRNNSYTCYTAAICG	SLC20A2	381	Q08357
LVYLLYCCFERVCLF	CMTR1	416	Q8N1G2
QCLNEVCFYSLRRVY	MFAP2	116	P55001
LCADEYRARCRSYSI	IRS4	331	O14654
YLGAICYCDLFCNRT	TINAGL1	66	Q9GZM7
NSKNRCDARTYCYLL	PUS1	191	Q9Y606
ISRAYALCVLYRNCV	INPP5D	36	Q92835
ALCVLYRNCVYTYRI	INPP5D	41	Q92835
AFRDRCFVSNRACYS	SLC3A1	661	Q07837
CLCNRFVRSKADEYY	ARHGAP5	36	Q13017
FCKDYALSYLSLRAC	SLC4A8	551	Q2Y0W8
QSFYTSRCGYRLCAR	TRAF5	431	O00463
HIRYNRCCYKFIFTS	B3GALT9	296	A8MXE2
SCAYLFCQRTFLSFI	CLCNKA	296	P51800
CRLSTYALYVNLYCS	CYSLTR1	96	Q9Y271
NVTAYYRTCLFRLCQ	TECTA	931	O75443
TCRNLASLDCYIYVR	ZNF77	36	Q15935
LSCGRRAVCRYYNND	SLCO2B1	631	O94956
ALQRRYYSPSCREFC	PIGH	16	Q14442
LRCFLTYQSCQSLIY	GTF3C4	771	Q9UKN8
TYQSCQSLIYRRCLL	GTF3C4	776	Q9UKN8
EAEALYSAYIRRCAC	TTC32	26	Q5I0X7
EYCLGCISNTASYLR	ATP6V0A1	726	Q93050
LCEKAYTNCFYLRRH	ZNF705B	176	P0CI00
LCEKAYTNCFYLRRH	ZNF705D	176	P0CH99
DFVEYVRSLACLCLY	S100A3	71	P33764
IFRCQDNCAERGYLY	WSCD2	156	Q2TBF2
LFSTYLARCQQYLCS	ZFYVE26	551	Q68DK2
CSFCRRSLSDPCYYN	ZMYM3	546	Q14202
TCNEYRKRFCYSSAL	ZNF284	176	Q2VY69
EYCLGCISNTASYLR	ATP6V0A2	741	Q9Y487
AYLVELCGLCYRAFT	UNC79	2236	Q9P2D8
ECRYCLRSYTQSGDL	ZBTB3	501	Q9H5J0
DLCKCSSSRQYLRYR	KDM5C	736	P41229