Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH3 MYH6 KIF9 MYH13 CENPE MYO18A	1.06e-06	118	57	6	GO:0003774
GeneOntologyMolecularFunction	ATP-dependent activity	MYH3 MYH6 KIF9 MYH13 CENPE MYO18A RNF213 SMC5 ABCD2 HSP90AB3P	8.24e-06	614	57	10	GO:0140657
GeneOntologyMolecularFunction	microfilament motor activity	MYH3 MYH6 MYH13	1.73e-04	38	57	3	GO:0000146
GeneOntologyMolecularFunction	ATP hydrolysis activity	MYH3 KIF9 MYO18A RNF213 SMC5 ABCD2 HSP90AB3P	2.49e-04	441	57	7	GO:0016887
GeneOntologyMolecularFunction	actin filament binding	MYH3 MYH6 MYH13 MYO18A NEB	4.70e-04	227	57	5	GO:0051015
GeneOntologyBiologicalProcess	membraneless organelle assembly	MYH3 MYH6 KIF9 CENPE DLGAP5 RNF213 PRKDC NEB CHMP4B	4.19e-06	475	55	9	GO:0140694
GeneOntologyBiologicalProcess	organelle assembly	FSIP2 STK36 MYH3 MYH6 KIF9 CENPE DLGAP5 WDR35 RNF213 PRKDC NEB CHMP4B IQCG	6.80e-06	1138	55	13	GO:0070925
GeneOntologyBiologicalProcess	positive regulation of mitotic metaphase/anaphase transition	CENPE DLGAP5 ANAPC7	9.80e-06	16	55	3	GO:0045842
GeneOntologyBiologicalProcess	positive regulation of metaphase/anaphase transition of cell cycle	CENPE DLGAP5 ANAPC7	1.19e-05	17	55	3	GO:1902101
GeneOntologyBiologicalProcess	positive regulation of mitotic sister chromatid separation	CENPE DLGAP5 ANAPC7	1.98e-05	20	55	3	GO:1901970
GeneOntologyBiologicalProcess	mitotic chromosome movement towards spindle pole	CENPE DLGAP5	4.17e-05	4	55	2	GO:0007079
GeneOntologyBiologicalProcess	microtubule-based movement	FSIP2 STK36 KIF9 CENPE DLGAP5 WDR35 MADD IQCG	4.57e-05	493	55	8	GO:0007018
GeneOntologyBiologicalProcess	positive regulation of chromosome separation	CENPE DLGAP5 ANAPC7	7.65e-05	31	55	3	GO:1905820
GeneOntologyBiologicalProcess	microtubule-based process	FSIP2 STK36 KIF9 AKAP9 CENPE DLGAP5 CCSER2 WDR35 CHMP4B MADD IQCG	9.18e-05	1058	55	11	GO:0007017
GeneOntologyBiologicalProcess	chromosome movement towards spindle pole	CENPE DLGAP5	1.45e-04	7	55	2	GO:0051305
GeneOntologyBiologicalProcess	positive regulation of mitotic nuclear division	CENPE DLGAP5 ANAPC7	3.22e-04	50	55	3	GO:0045840
GeneOntologyCellularComponent	myosin filament	MYH3 MYH6 MYH13 MYO18A	6.02e-07	25	57	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH3 MYH6 MYH13 MYO18A	9.68e-07	28	57	4	GO:0016460
GeneOntologyCellularComponent	muscle myosin complex	MYH3 MYH6 MYH13	1.05e-05	16	57	3	GO:0005859
GeneOntologyCellularComponent	myosin complex	MYH3 MYH6 MYH13 MYO18A	2.02e-05	59	57	4	GO:0016459
GeneOntologyCellularComponent	actin cytoskeleton	MYH3 MYH6 KIF9 MYH13 MYO18A NEB IQCG	9.32e-04	576	57	7	GO:0015629
Domain	Myosin_tail_1	MYH3 MYH6 MYH13 MYO18A	1.72e-07	18	53	4	PF01576
Domain	Myosin_tail	MYH3 MYH6 MYH13 MYO18A	1.72e-07	18	53	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH3 MYH6 MYH13 MYO18A	2.17e-07	19	53	4	IPR027401
Domain	-	MYH3 MYH6 MYH13 MYO18A	2.17e-07	19	53	4	4.10.270.10
Domain	IQ	MYH3 MYH6 MYH13 MYO18A IQCG	1.71e-06	71	53	5	PF00612
Domain	IQ	MYH3 MYH6 MYH13 MYO18A IQCG	3.30e-06	81	53	5	SM00015
Domain	MYOSIN_MOTOR	MYH3 MYH6 MYH13 MYO18A	3.97e-06	38	53	4	PS51456
Domain	Myosin_head	MYH3 MYH6 MYH13 MYO18A	3.97e-06	38	53	4	PF00063
Domain	Myosin_head_motor_dom	MYH3 MYH6 MYH13 MYO18A	3.97e-06	38	53	4	IPR001609
Domain	MYSc	MYH3 MYH6 MYH13 MYO18A	3.97e-06	38	53	4	SM00242
Domain	IQ_motif_EF-hand-BS	MYH3 MYH6 MYH13 MYO18A IQCG	5.55e-06	90	53	5	IPR000048
Domain	IQ	MYH3 MYH6 MYH13 MYO18A IQCG	6.52e-06	93	53	5	PS50096
Domain	Myosin_N	MYH3 MYH6 MYH13	9.58e-06	15	53	3	IPR004009
Domain	Myosin_N	MYH3 MYH6 MYH13	9.58e-06	15	53	3	PF02736
Domain	TPR-like_helical_dom	EIF3L WDR35 PRKDC ANAPC7 EDRF1 TTC6	4.97e-05	233	53	6	IPR011990
Domain	P-loop_NTPase	MYH3 MYH6 KIF9 MYH13 CENPE MYO18A RNF213 SMC5 ABCD2	5.77e-04	848	53	9	IPR027417
Domain	TPR-contain_dom	PRKDC ANAPC7 EDRF1 TTC6	8.62e-04	150	53	4	IPR013026
Domain	TPR	PRKDC ANAPC7 EDRF1 TTC6	1.23e-03	165	53	4	PS50005
Domain	TPR_REGION	PRKDC ANAPC7 EDRF1 TTC6	1.23e-03	165	53	4	PS50293
Domain	ARM-type_fold	STK36 IPO7 PDS5A PRKDC SDAD1	2.69e-03	339	53	5	IPR016024
Domain	-	STK36 IPO7 PDS5A PRKDC	3.61e-03	222	53	4	1.25.10.10
Domain	Kinesin_motor_CS	KIF9 CENPE	6.04e-03	41	53	2	IPR019821
Domain	Kinesin-like_fam	KIF9 CENPE	6.62e-03	43	53	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF9 CENPE	6.93e-03	44	53	2	PS00411
Domain	-	KIF9 CENPE	6.93e-03	44	53	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF9 CENPE	6.93e-03	44	53	2	IPR001752
Domain	Kinesin	KIF9 CENPE	6.93e-03	44	53	2	PF00225
Domain	KISc	KIF9 CENPE	6.93e-03	44	53	2	SM00129
Domain	KINESIN_MOTOR_2	KIF9 CENPE	6.93e-03	44	53	2	PS50067
Domain	ARM-like	STK36 IPO7 PDS5A PRKDC	7.18e-03	270	53	4	IPR011989
Domain	Cyt_P450_E_grp-I	CYP20A1 CYP4F11	7.23e-03	45	53	2	IPR002401
Domain	HEAT	STK36 PRKDC	8.20e-03	48	53	2	PF02985
Pathway	REACTOME_STRIATED_MUSCLE_CONTRACTION	MYH3 MYH6 NEB	1.30e-04	35	40	3	MM15005
Pathway	REACTOME_STRIATED_MUSCLE_CONTRACTION	MYH3 MYH6 NEB	1.42e-04	36	40	3	M18647
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	MYH3 MYH6 NEB	1.67e-04	38	40	3	M39549
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYH3 MYH6 MYH13 IPO7 EIF3L AHCY MYO18A RCN2 PRKDC EBNA1BP2	9.11e-08	647	57	10	26618866
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	IPO7 EIF3L AHCY RCN2 RNF213 PRKDC ANAPC7 HSP90AB3P	9.15e-08	344	57	8	36282215
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CEP78 CENPE EIF3L CCSER2 AHCY RCN2 PDS5A PRKDC EBNA1BP2 SMC5 CHMP4B ANAPC7	3.03e-07	1155	57	12	20360068
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	IPO7 CEP78 EIF3L AHCY RCN2 PRKDC EBNA1BP2 ARIH1 ANAPC7 SDAD1 TTC6 HSP90AB3P	1.39e-06	1335	57	12	29229926
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO7 DHCR24 EIF3L ZC3HAV1L AHCY RCN2 PDS5A PRKDC EBNA1BP2 CHMP4B ANAPC7 SDAD1	2.73e-06	1425	57	12	30948266
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	IPO7 DHCR24 EIF3L CYP20A1 CCSER2 PDS5A PRKDC EBNA1BP2 TBC1D23 SMC5 SDAD1	3.47e-06	1203	57	11	29180619
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	EXOC6 CEP78 CENPE RNPC3 MYO18A PRKDC EBNA1BP2 SMC5 SDAD1	3.78e-06	759	57	9	35915203
Pubmed	Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study.	MYH3 MYH6	7.91e-06	3	57	2	1939265
Pubmed	Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro.	MYH3 MYH6	7.91e-06	3	57	2	1694848
Pubmed	Global landscape of HIV-human protein complexes.	AKAP9 DHCR24 EIF3L AHCY RCN2 RNF213 PRKDC	9.69e-06	457	57	7	22190034
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	EXOC6 IPO7 RCN2 RNF213 PRKDC	1.28e-05	183	57	5	23956138
Pubmed	DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.	MYO18A PRKDC	1.58e-05	4	57	2	24485452
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MYH3 MYH6 AKAP9 MYH13 EIF3L AHCY RCN2 ANAPC7 SDAD1	1.61e-05	910	57	9	36736316
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IPO7 DHCR24 EIF3L RCN2 RNF213 PDS5A RARS2 PRKDC EBNA1BP2 CHMP4B SDAD1	1.88e-05	1440	57	11	30833792
Pubmed	Developmental regulation of myosin gene expression in mouse cardiac muscle.	MYH3 MYH6	2.63e-05	5	57	2	2277065
Pubmed	Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.	CENPE ANAPC7	2.63e-05	5	57	2	10477750
Pubmed	Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.	MYH3 MYH6	3.94e-05	6	57	2	28381556
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH3 MYH13	3.94e-05	6	57	2	10077619
Pubmed	Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice.	AKAP9 IQCG	3.94e-05	6	57	2	12855593
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	DHCR24 EIF3L MYO18A PRKDC EBNA1BP2	5.07e-05	244	57	5	28902428
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH3 MYH13	5.51e-05	7	57	2	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH3 MYH6	5.51e-05	7	57	2	16819597
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	IPO7 CEP78 MYO18A RCN2 RNF213 PRKDC ARIH1	5.56e-05	601	57	7	33658012
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	PDS5A PRKDC ARIH1 ANAPC7	6.13e-05	129	57	4	23022380
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	MYH6 IPO7 EIF3L AHCY RCN2 RNF213 PRKDC NEB	6.72e-05	844	57	8	25963833
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH3 MYH6	7.34e-05	8	57	2	3864153
Pubmed	Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.	MYH3 NEB	7.34e-05	8	57	2	1618148
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5A SMC5	1.18e-04	10	57	2	22751501
Pubmed	The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.	MYH3 MYH6 NEB	1.40e-04	61	57	3	27166947
Pubmed	Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development.	MYH3 NEB	1.44e-04	11	57	2	7720708
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	IPO7 MYO18A PRKDC	1.55e-04	63	57	3	37052853
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	IPO7 EIF3L AHCY PDS5A EBNA1BP2 ARIH1	1.57e-04	494	57	6	26831064
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MYH13 CENPE NEB SMC5 SDAD1 TTC6	1.62e-04	497	57	6	36774506
Pubmed	Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.	MYH6 MYH13	1.72e-04	12	57	2	8424456
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CENPE EIF3L DLGAP5 RCN2 RNF213 MADD IQCG	1.90e-04	733	57	7	34672954
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MYH3 CENPE EIF3L RNF213 PDS5A PRKDC FAM186B	1.95e-04	736	57	7	29676528
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	STK36 IPO7 DHCR24 ZC3HAV1L MYO18A EBNA1BP2 ANAPC7	2.26e-04	754	57	7	35906200
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	IPO7 EIF3L RNF213 PDS5A PRKDC ARIH1 SMC5 ANAPC7	2.37e-04	1014	57	8	32416067
Pubmed	Sequence and expression of murine type I hair keratins mHa2 and mHa3.	KIF9 CENPE	2.37e-04	14	57	2	7514534
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	PDS5A ANAPC7	2.37e-04	14	57	2	11076961
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	IPO7 EIF3L DLGAP5 AHCY RCN2 PDS5A PRKDC EBNA1BP2 ARIH1	2.43e-04	1297	57	9	33545068
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	AKAP9 RNF213 PRKDC	2.70e-04	76	57	3	27542412
Pubmed	Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.	MYH6 RNF213	3.12e-04	16	57	2	29859889
Pubmed	DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death.	MYH3 MYH6	3.12e-04	16	57	2	22090424
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	AKAP9 AHCY PRKDC	3.37e-04	82	57	3	30274258
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	IPO7 EIF3L RCN2 PRKDC EBNA1BP2 ANAPC7	3.40e-04	571	57	6	37167062
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	AKAP9 MYH13 IPO7 CEP78 AHCY RCN2 EBNA1BP2 CHMP4B SDAD1	3.66e-04	1371	57	9	36244648
Pubmed	Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.	PDS5A PRKDC ANAPC7	4.01e-04	87	57	3	24169447
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	DHCR24 RCN2 ARIH1 SDAD1	4.12e-04	212	57	4	33462405
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	IPO7 EIF3L RCN2 RARS2 PRKDC	4.13e-04	383	57	5	29331416
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FSIP2 IPO7 DLGAP5 PDS5A EBNA1BP2 ANAPC7	4.74e-04	608	57	6	36089195
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	DHCR24 EIF3L ZC3HAV1L PRKDC EBNA1BP2 SDAD1	5.04e-04	615	57	6	31048545
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MYH3 MYH6 MYH13 MYO18A PRKDC EBNA1BP2 NEB ANAPC7 CCDC148	5.27e-04	1442	57	9	35575683
Pubmed	Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.	FAM184A FSTL5	5.43e-04	21	57	2	24407287
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	IPO7 EIF3L AHCY MYO18A RCN2 PDS5A PRKDC ANAPC7	5.44e-04	1149	57	8	35446349
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH3 MYH6	5.97e-04	22	57	2	24301466
Pubmed	Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.	PRKDC ANAPC7	5.97e-04	22	57	2	31839203
Pubmed	Defining the membrane proteome of NK cells.	IPO7 CENPE DHCR24 EIF3L CYP20A1 MYO18A RNF213 PRKDC	6.06e-04	1168	57	8	19946888
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	AKAP9 PRKDC HSP90AB3P	6.21e-04	101	57	3	26949739
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	IPO7 EIF3L PRKDC EBNA1BP2 SDAD1	6.61e-04	425	57	5	21081503
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	FAM184A DHCR24 EIF3L RCN2 PDS5A CHMP4B ANAPC7 SDAD1 EDRF1	6.90e-04	1497	57	9	31527615
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	AKAP9 EIF3L PRKDC NEB SDAD1	7.12e-04	432	57	5	23455922
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF9 CENPE	7.73e-04	25	57	2	9275178
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	RNPC3 PRKDC EBNA1BP2 ANAPC7	7.75e-04	251	57	4	31076518
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	EXOC6 CEP78 EIF3L CCSER2	7.75e-04	251	57	4	29778605
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	DHCR24 PRKDC EBNA1BP2 SDAD1	7.98e-04	253	57	4	29911972
Pubmed	Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans.	MYH3 NEB	8.36e-04	26	57	2	30121012
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	EXOC6 IPO7 CEP78 DHCR24 EIF3L PDS5A PRKDC	8.51e-04	942	57	7	31073040
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	IPO7 DHCR24 PRKDC	8.60e-04	113	57	3	30352685
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	IPO7 MATN2 EIF3L MYO18A PRKDC EBNA1BP2 CHMP4B	8.88e-04	949	57	7	36574265
Pubmed	An integrative method for scoring candidate genes from association studies: application to warfarin dosing.	EXOC6 RCN2	9.02e-04	27	57	2	21044367
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	EIF3L ZC3HAV1L RNF213 ANAPC7	9.09e-04	262	57	4	36880596
Pubmed	Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.	DHCR24 CYP4F11	9.71e-04	28	57	2	20689807
Pubmed	Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.	IPO7 PRKDC	9.71e-04	28	57	2	35227662
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	IPO7 PDS5A PRKDC	9.75e-04	118	57	3	27377895
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	MYH6 DLGAP5 RCN2	9.75e-04	118	57	3	30979931
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	IPO7 DHCR24 AHCY RCN2 RARS2 PRKDC EBNA1BP2 ANAPC7	9.76e-04	1257	57	8	37317656
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	IPO7 EIF3L AHCY MYO18A RCN2 PRKDC EBNA1BP2 SDAD1	9.76e-04	1257	57	8	36526897
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	EIF3L AHCY PDS5A PRKDC ARIH1 TBC1D23	1.02e-03	704	57	6	29955894
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	IPO7 ZC3HAV1L AHCY RCN2 PDS5A PRKDC	1.05e-03	708	57	6	39231216
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	EIF3L AHCY RCN2 PRKDC EBNA1BP2 MADD	1.09e-03	714	57	6	28302793
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	STK36 EIF3L AHCY RCN2 PDS5A RARS2 EBNA1BP2 SDAD1	1.12e-03	1284	57	8	17353931
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEP78 MYO18A EBNA1BP2 SMC5 CHMP4B ANAPC7	1.17e-03	724	57	6	36232890
Pubmed	A human MAP kinase interactome.	MYO18A RAPGEF1 PRKDC NEB MADD	1.20e-03	486	57	5	20936779
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	CCSER2 WDR35 MADD	1.23e-03	128	57	3	30995482
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STK36 RNPC3 WDR35 RNF213 PDS5A	1.28e-03	493	57	5	15368895
Pubmed	CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.	IPO7 AHCY PRKDC HSP90AB3P	1.29e-03	288	57	4	31501420
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	MYH3 MYH13 AHCY OLFM4 NEB CHMP4B IQCG	1.32e-03	1016	57	7	19056867
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KANSL1L MYH3 AKAP9 IPO7 NEB	1.33e-03	497	57	5	23414517
Pubmed	Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.	FSTL5 CYP20A1	1.35e-03	33	57	2	20966902
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	AKAP9 DHCR24 MYO18A RCN2 SDAD1	1.40e-03	503	57	5	36217030
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	AKAP9 IPO7 RNPC3 EIF3L MYO18A EBNA1BP2	1.44e-03	754	57	6	33060197
Interaction	TPM2 interactions	MYH3 MYH6 AKAP9 MYO18A RNF213 EBNA1BP2 NEB	1.99e-06	209	57	7	int:TPM2
Interaction	AKTIP interactions	IPO7 EIF3L PDS5A PRKDC NEB	1.12e-05	104	57	5	int:AKTIP
Cytoband	20q11.22	AHCY CHMP4B	9.81e-04	37	57	2	20q11.22
GeneFamily	Myosin heavy chains	MYH3 MYH6 MYH13	1.49e-06	15	28	3	1098
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF9 CENPE	2.30e-03	46	28	2	622
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	ANAPC7 TTC6	1.36e-02	115	28	2	769
Coexpression	MITSIADES_RESPONSE_TO_APLIDIN_DN	DHCR24 DLGAP5 AHCY PDS5A PRKDC ARHGAP19	1.71e-05	250	57	6	M11318
Coexpression	GSE13547_2H_VS_12_H_ANTI_IGM_STIM_ZFX_KO_BCELL_DN	CENPE RNPC3 AHCY SDAD1 ARHGAP19	3.85e-05	174	57	5	M2996
Coexpression	TARTE_PLASMA_CELL_VS_PLASMABLAST_DN	CENPE DHCR24 DLGAP5 AHCY PRKDC EBNA1BP2	5.40e-05	307	57	6	M19745
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	AKAP9 IPO7 CENPE CCSER2 PDS5A ARIH1 SMC5	6.59e-05	466	57	7	M13522
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_DN	IPO7 DHCR24 DLGAP5 AHCY EBNA1BP2	7.29e-05	199	57	5	M8314
Coexpression	GSE26156_DOUBLE_POSITIVE_VS_CD4_SINGLE_POSITIVE_THYMOCYTE_DN	IPO7 CENPE DLGAP5 AHCY EBNA1BP2	7.29e-05	199	57	5	M8299
Coexpression	GSE21379_TFH_VS_NON_TFH_CD4_TCELL_UP	EXOC6 FAM184A WDR35 CPXM1 PDS5A	7.46e-05	200	57	5	M7500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	AKAP9 IPO7 CENPE DLGAP5 CCSER2 PDS5A ARIH1 SMC5 ARHGAP19	8.93e-05	856	57	9	M4500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	FAM184A AKAP9 IPO7 CENPE PDS5A PRKDC SMC5 CHMP4B	1.30e-06	311	55	8	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	CEP78 CENPE DLGAP5 SDAD1 ARHGAP19	1.66e-05	123	55	5	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k3_1000
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#3_top-relative-expression-ranked_200	SERPINI1 MATN2 RNF213	7.02e-05	31	55	3	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k3_200
ToppCell	IIF-Lymphocyte-T_NK-T_NK_proliferative\|IIF / Disease, Lineage and Cell Type	FAM184A CENPE DHCR24 DLGAP5 CYP4F11	3.82e-06	184	57	5	ab8b45ce40e8c5f66e5c23332a591b4f9cba4ce1
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	STK36 WDR35 TTC6 CCDC148 IQCG	5.46e-06	198	57	5	6d90b541fde357fbb40f8f7d4e8628a48b679718
Drug	S-(-)-Etomoxir	MYH3 MYH6 MYH13 MYO18A ANAPC7	4.73e-06	100	56	5	CID000060765
Drug	formycin triphosphate	MYH3 MYH6 MYH13 MYO18A	7.52e-06	51	56	4	CID000122274
Drug	purealin	MYH3 MYH6 MYH13 MYO18A	1.26e-05	58	56	4	CID006419303
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH3 MYH6 MYH13	8.12e-07	10	57	3	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	1.49e-06	12	57	3	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH3 MYH6 MYH13	1.49e-06	12	57	3	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	1.93e-06	13	57	3	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH3 MYH6 MYH13	3.06e-06	15	57	3	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	1.11e-04	48	57	3	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	3.56e-04	71	57	3	DOID:0050700 (implicated_via_orthology)
Disease	Pontoneocerebellar hypoplasia	RARS2 TBC1D23	4.32e-04	16	57	2	cv:C1261175
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH3 MYH6 MYH13	5.05e-04	80	57	3	DOID:12930 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FMKNVLKETNFKMNQ	AKAP9	2411	Q99996
LVFHMKNEMRNIKYK	CCDC148	11	Q8NFR7
MKQLQKSYKALADQM	ABCD2	316	Q9UBJ2
DFQHHNYKAMRKLMK	CPXM1	296	Q96SM3
QGADHMAKILKYQTM	CEP78	191	Q5JTW2
LKNMGYAAKAMKAAH	CHMP4B	106	Q9H444
NIKKKVYHMDMEAQR	FAM186B	656	Q8IYM0
YSQEMHLKMSKKIAQ	FAM184A	36	Q8NB25
QEMKAKSNLENRYMK	IQCG	256	Q9H095
QMSFKHYAMQEAKQQ	RCN2	91	Q14257
KNENNSHAFMKKMAE	PDS5A	1041	Q29RF7
NMEVMKSIIQKYQHK	CRPPA	101	A4D126
EHKLYAQVKQKMEEM	ARIH1	431	Q9Y4X5
KINMMLANLYKKAGQ	ANAPC7	136	Q9UJX3
KHVVKHYGQQMKLSM	KANSL1L	251	A0AUZ9
NFNSAKDMKKAVAHM	MATN2	711	O00339
HNLISYMLLMKVNKN	MADD	1376	Q8WXG6
KYEMINKQNEQMHAL	EIF3L	356	Q9Y262
NMMMKKNQNKKHYGT	EDRF1	466	Q3B7T1
MLQQSKILKYVSHMK	HSP90AB3P	336	Q58FF7
LQDLKNHYKKKMEVM	CCDC178	281	Q5BJE1
EKKMAYHLQKMQDTG	FSIP2	296	Q5CZC0
EKAHMMNAIKKYQKG	EBNA1BP2	191	Q99848
KKIYKDQMEYMLQNH	IPO7	446	O95373
MKELQTQYDALKKQM	MYO18A	1326	Q92614
KKIFNYMIHVNRNIM	NEMP2	136	A6NFY4
DKIYNISMKHPQEMK	FOLH1B	301	Q9HBA9
IEQKHNYLKTMMGLQ	KIF9	771	Q9HAQ2
SLQKQNKMKFGKNMY	EXOC6	231	Q8TAG9
SKMKNMLLDLQNQKY	FSTL5	146	Q8N475
KNNQTMKHDAKMRYL	CCSER2	376	Q9H7U1
KYKKTHKNIMINLMD	DHCR24	106	Q15392
KPYMKIFNKSVNIMH	CYP4F11	161	Q9HBI6
TMAKKLFHDMNVNYK	GLRX2	81	Q9NS18
MNHNMNKNVFRKKVV	DLGAP5	541	Q15398
KNMTRKKQYEDALMQ	CYP20A1	216	Q6UW02
VHNLYKMMANGILKV	AHCY	161	P23526
NFKTLHMDFEQKYKM	CENPE	821	Q02224
QMMKKYFNAAVNHVD	SERPINI1	126	Q99574
KKHFQQVFQMLKIMG	RARS2	351	Q5T160
AVMHYGNMKFKQKQR	MYH3	356	P11055
DLAQYKTHKDKNVMM	SDAD1	416	Q9NVU7
AIMHYGNMKFKQKQR	MYH6	356	P13533
MHKMQEKVQSINYNP	OLFM4	471	Q6UX06
YKRMAEEAMQKKHQN	STK36	306	Q9NRP7
YVKRLHDKMKMQLNV	RNF213	2001	Q63HN8
NYEHLFMDIKNKMAQ	RNF213	4986	Q63HN8
MGHKQNAMKDYQDAI	TTC6	361	Q86TZ1
KFYVQVLHLMNKMNL	RNPC3	181	Q96LT9
KKNKHMLAYMQLLED	RAPGEF1	546	Q13905
YMNMVLAHFLQKNKE	TBC1D23	411	Q9NUY8
GAVMHYGNMKFKQKQ	MYH13	356	Q9UKX3
KQDKNKMSAYNLALM	ARHGAP19	256	Q14CB8
MVAKNAEMHKNKLQY	PRKDC	326	P78527
HIYDNQGNFMIKMKL	WDR35	181	Q9P2L0
MLTINMKDNKNAKYI	SMC5	486	Q8IY18
YKHMKLHKMLENTDN	ZC3HAV1L	241	Q96H79
QEMMSQIKYKKNALE	NEB	4381	P20929