Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	methyltransferase complex	CBLL1 KMT2B CXXC1 ASH2L SIRT1 KMT2D	8.51e-05	108	139	6	GO:0034708
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2B CXXC1 ASH2L SIRT1 KMT2D	1.44e-04	75	139	5	GO:0035097
Domain	IQ	MYO7B MYO10 OBSCN IQCA1 IQCB1 IQGAP3	3.39e-05	81	141	6	SM00015
Domain	Med13_N	MED13L MED13	5.66e-05	2	141	2	PF11597
Domain	Mediator_Med13_N_met/fun	MED13L MED13	5.66e-05	2	141	2	IPR021643
Domain	Med13_C	MED13L MED13	5.66e-05	2	141	2	PF06333
Domain	MAGEA3/MAGEA6	MAGEA3 MAGEA6	5.66e-05	2	141	2	IPR030097
Domain	Mediator_Med13	MED13L MED13	5.66e-05	2	141	2	IPR009401
Domain	IQ_motif_EF-hand-BS	MYO7B MYO10 OBSCN IQCA1 IQCB1 IQGAP3	6.16e-05	90	141	6	IPR000048
Domain	IQ	MYO7B MYO10 OBSCN IQCA1 IQCB1 IQGAP3	7.40e-05	93	141	6	PS50096
Domain	IQ	MYO7B MYO10 OBSCN IQCB1 IQGAP3	1.99e-04	71	141	5	PF00612
Domain	PHD	KMT2B PHRF1 DIDO1 CXXC1 KMT2D	2.58e-04	75	141	5	PF00628
Domain	Znf_PHD-finger	KMT2B PHRF1 DIDO1 CXXC1 KMT2D	3.29e-04	79	141	5	IPR019787
Domain	VDCC_L_a1su	CACNA1D CACNA1S	3.36e-04	4	141	2	IPR005446
Domain	DnaJ	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	4.68e-04	48	141	4	PF00226
Domain	DNAJ_1	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	5.07e-04	49	141	4	PS00636
Domain	DNAJ_2	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	5.07e-04	49	141	4	PS50076
Domain	DnaJ	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	5.07e-04	49	141	4	SM00271
Domain	-	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	5.07e-04	49	141	4	1.10.287.110
Domain	FYrich_C	KMT2B KMT2D	5.58e-04	5	141	2	IPR003889
Domain	FYrich_N	KMT2B KMT2D	5.58e-04	5	141	2	IPR003888
Domain	FYRC	KMT2B KMT2D	5.58e-04	5	141	2	SM00542
Domain	FYRN	KMT2B KMT2D	5.58e-04	5	141	2	SM00541
Domain	FYRN	KMT2B KMT2D	5.58e-04	5	141	2	PF05964
Domain	FYRC	KMT2B KMT2D	5.58e-04	5	141	2	PF05965
Domain	FYRC	KMT2B KMT2D	5.58e-04	5	141	2	PS51543
Domain	FYRN	KMT2B KMT2D	5.58e-04	5	141	2	PS51542
Domain	PHD	KMT2B PHRF1 DIDO1 CXXC1 KMT2D	5.70e-04	89	141	5	SM00249
Domain	DnaJ_domain	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	5.91e-04	51	141	4	IPR001623
Domain	Znf_PHD	KMT2B PHRF1 DIDO1 CXXC1 KMT2D	6.31e-04	91	141	5	IPR001965
Domain	ZF_PHD_2	KMT2B PHRF1 DIDO1 CXXC1 KMT2D	7.68e-04	95	141	5	PS50016
Domain	ZF_PHD_1	KMT2B PHRF1 DIDO1 CXXC1 KMT2D	8.05e-04	96	141	5	PS01359
Domain	Znf_FYVE_PHD	KMT2B PHRF1 DIDO1 FYCO1 CXXC1 KMT2D	8.80e-04	147	141	6	IPR011011
Domain	DnaJ_domain_CS	DNAJC5 DNAJB2 DNAJC5B	1.08e-03	27	141	3	IPR018253
Domain	Trimer_CC	CORO1C CORO1B	1.16e-03	7	141	2	IPR015049
Domain	DUF1899	CORO1C CORO1B	1.16e-03	7	141	2	IPR015048
Domain	Ca_chan_IQ	CACNA1D CACNA1S	1.16e-03	7	141	2	SM01062
Domain	Ca_chan_IQ	CACNA1D CACNA1S	1.16e-03	7	141	2	PF08763
Domain	Trimer_CC	CORO1C CORO1B	1.16e-03	7	141	2	PF08954
Domain	DUF1899	CORO1C CORO1B	1.16e-03	7	141	2	PF08953
Domain	Coronin	CORO1C CORO1B	1.16e-03	7	141	2	IPR015505
Domain	VDCC_a1su_IQ	CACNA1D CACNA1S	1.16e-03	7	141	2	IPR014873
Domain	GPHH	CACNA1D CACNA1S	1.16e-03	7	141	2	PF16905
Domain	GPHH_dom	CACNA1D CACNA1S	1.16e-03	7	141	2	IPR031649
Domain	DUF1899	CORO1C CORO1B	1.16e-03	7	141	2	SM01166
Domain	Calx_beta	ADGRV1 FREM2	1.54e-03	8	141	2	SM00237
Domain	Calx_beta	ADGRV1 FREM2	1.97e-03	9	141	2	IPR003644
Domain	MYTH4	MYO7B MYO10	1.97e-03	9	141	2	PS51016
Domain	MyTH4	MYO7B MYO10	1.97e-03	9	141	2	SM00139
Domain	MyTH4_dom	MYO7B MYO10	1.97e-03	9	141	2	IPR000857
Domain	MyTH4	MYO7B MYO10	1.97e-03	9	141	2	PF00784
Domain	zf-C2H2_11	ZNF592 ZNF687	1.97e-03	9	141	2	PF16622
Domain	Calx-beta	ADGRV1 FREM2	1.97e-03	9	141	2	PF03160
Domain	-	CBLL1 TRAF6 KMT2B UBE4B PHRF1 DIDO1 FYCO1 CBLB CXXC1 KMT2D	2.19e-03	449	141	10	3.30.40.10
Domain	Protein_kinase_ATP_BS	SPEG OBSCN TESK1 NRK MARK4 PRKCA TNK2 EIF2AK1 MAPK13	2.37e-03	379	141	9	IPR017441
Domain	VDCCAlpha1	CACNA1D CACNA1S	2.45e-03	10	141	2	IPR002077
Domain	Znf_RING/FYVE/PHD	CBLL1 TRAF6 KMT2B UBE4B PHRF1 DIDO1 FYCO1 CBLB CXXC1 KMT2D	2.57e-03	459	141	10	IPR013083
Domain	ZF_CXXC	KMT2B CXXC1	2.98e-03	11	141	2	PS51058
Domain	Znf_CXXC	KMT2B CXXC1	2.98e-03	11	141	2	IPR002857
Domain	zf-CXXC	KMT2B CXXC1	2.98e-03	11	141	2	PF02008
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DGCR2 KMT2B UBE4B MYO10 POLE SPEG OBSCN IRF5 FYCO1 CORO1B MED13L TESK1 BABAM2 MADD ARHGEF10L ARHGEF40 KMT2D GRTP1 ZNF592 MARK4 TNK2 ATG9A ALKBH6 IQGAP3 MED13 CEP170B ZNF687 ARAP1	1.30e-14	1105	144	28	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FNBP1 KMT2B UBE4B ZCCHC8 BCL7C PHRF1 ZMYM2 DIDO1 CHD7 ZNF768 SIRT1 KMT2D ZNF592 DYNC1LI1 PLA2G4A PLCB3 DDX41 MED13 ZNF687	5.77e-10	774	144	19	15302935
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DGCR2 NYAP2 PHRF1 LARS1 NFASC DIDO1 ADGRV1 ARHGAP11A DICER1 ARHGEF10L ZNF592 MED13 ZNF687 ARAP1	4.84e-08	529	144	14	14621295
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2B CXXC1 ASH2L KMT2D	1.36e-07	12	144	4	27563068
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNBP1 INTU UBE4B MYO10 SPEG GON4L MED13L MADD GRAMD1B MARK4 RIMBP2 CEP170B	1.45e-07	407	144	12	12693553
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ZCCHC8 BCL7C ZMYM2 CHD7 MED13L ASH2L XAB2 KMT2D NFATC2IP MED13	1.94e-07	268	144	10	33640491
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CBLL1 KMT2B CWC27 ZCCHC8 CORO1C PHRF1 ZMYM2 GON4L DIDO1 CHD7 ZBTB7B BABAM2 DICER1 ZNF768 ASH2L XAB2 ZNF592 PURA IQGAP3 MED13 CEP170B ZNF687	2.48e-07	1497	144	22	31527615
Pubmed	The functional interactome landscape of the human histone deacetylase family.	USP9X NARS1 ZMYM2 DICER1 XAB2 ZNF592 IQCB1 DDX41 DNAJB2 ZNF687	3.87e-07	289	144	10	23752268
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CBLL1 KMT2B ZCCHC8 PHRF1 ZMYM2 DIDO1 CHD7 NCAPH2 CHD1L ARHGAP11A ZBTB7B BABAM2 CXXC1 ZNF768 ASH2L XAB2 KMT2D DDX41 TOR1AIP1 ZNF687	4.22e-07	1294	144	20	30804502
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ZCCHC8 CORO1C BCL7C KRI1 NCAPH2 CHD1L BABAM2 ASH2L XAB2 DYNC1LI1 DDX41	4.51e-07	370	144	11	22922362
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CBLL1 NYAP2 NHSL2 USP9X CORO1C ZMYM2 NFASC DIDO1 FYCO1 CHD7 CORO1B ZBTB1 LZTS1 PURA PRKCA RIMBP2 CEP170B	5.54e-07	963	144	17	28671696
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2B ASH2L KMT2D	6.91e-07	5	144	3	26320581
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	LARS1 ZMYM2 GON4L DIDO1 CHD7 ASH2L PURA DYNC1LI1 CCDC97 DDX41 ZNF687	8.36e-07	394	144	11	27248496
Pubmed	CHARGE and Kabuki syndromes: a phenotypic and molecular link.	CHD7 ASH2L KMT2D	1.38e-06	6	144	3	24705355
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2B CXXC1 ASH2L KMT2D	1.95e-06	22	144	4	26886794
Pubmed	Human transcription factor protein interaction networks.	KMT2B USP9X CORO1C BCL7C LARS1 ZMYM2 KRI1 GON4L DIDO1 IRF5 CHD7 ZBTB1 CXXC1 ZNF768 ASH2L SIRT1 KMT2D ZNF592 PURA ZNF687	1.95e-06	1429	144	20	35140242
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2B ASH2L KMT2D	2.40e-06	7	144	3	30604749
Pubmed	Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.	KMT2B ASH2L KMT2D	2.40e-06	7	144	3	23995757
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CORO1C GON4L CHD1L MED13L ARHGAP11A F5 BABAM2 ZNF768 NFATC2IP ZNF592 TOR1AIP1 MED13 ZNF687	3.11e-06	645	144	13	25281560
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2B ASH2L KMT2D	5.73e-06	9	144	3	22665483
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZCCHC8 USP9X ZMYM2 MED13L ASH2L KMT2D MED13	6.56e-06	167	144	7	20362541
Pubmed	Functional proteomics mapping of a human signaling pathway.	DGCR2 KMT2B ZCCHC8 ZMYM2 CBLB ASH2L XAB2 KMT2D ZNF592 MAPK13 DNAJB2 PCDH1	7.03e-06	591	144	12	15231748
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2B CXXC1 ASH2L KMT2D	8.13e-06	31	144	4	20516061
Pubmed	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.	KMT2B CXXC1 ASH2L	8.17e-06	10	144	3	18838538
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	KMT2B CWC27 BCL7C ZMYM2 DIDO1 CHD7 CHD1L ARHGAP11A SIRT1 NFATC2IP ZNF592 DDX41	9.34e-06	608	144	12	36089195
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2B WWOX ZCCHC8 ZMYM2 ZDBF2 CHD7 ZBTB1 KMT2D ZNF592 ZNF687	1.04e-05	418	144	10	34709266
Pubmed	Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.	CXXC1 ASH2L KMT2D	1.12e-05	11	144	3	18082152
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	WWOX CORO1C ZDBF2 CHD7 CORO1B DICER1 PAIP1 MADD IQCB1 DYNC1LI1 DNAJC5 TOR1AIP1 ZNF687	1.22e-05	733	144	13	34672954
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	USP9X CORO1C NFASC ADGRV1 MAPRE3 PURA MARK4 DYNC1LI1 TNK2 CEP170B	1.32e-05	430	144	10	32581705
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FNBP1 INTU WWOX UBE4B TRPM2 OBSCN NFASC CHD1L FNBP1L ADGRV1 BABAM2 TULP3 GRTP1 PURA KNDC1 TNK2 PCDH1 CEP170B ARAP1	1.33e-05	1489	144	19	28611215
Pubmed	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.	KMT2B ASH2L KMT2D	1.49e-05	12	144	3	17707229
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	FNBP1 NYAP2 USP9X POLE ZMYM2 ZDBF2 CHD7 BABAM2 ASH2L KMT2D LZTS1 ZNF687	1.51e-05	638	144	12	31182584
Pubmed	Host cytosolic phospholipase A₂α contributes to group B Streptococcus penetration of the blood-brain barrier.	PLA2G4A PRKCA	1.70e-05	2	144	2	21825068
Pubmed	ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Colorectal Tumorigenesis.	TRAF6 NOL3	1.70e-05	2	144	2	32816906
Pubmed	miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.	MAGEA3 MAGEA6	1.70e-05	2	144	2	30056111
Pubmed	Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis.	TRPM2 PRKCA	1.70e-05	2	144	2	24337049
Pubmed	Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).	KMT2B KMT2D	1.70e-05	2	144	2	35640156
Pubmed	Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover.	CORO1C CORO1B	1.70e-05	2	144	2	35657370
Pubmed	CHARGE and Kabuki Syndromes: Gene-Specific DNA Methylation Signatures Identify Epigenetic Mechanisms Linking These Clinically Overlapping Conditions.	CHD7 KMT2D	1.70e-05	2	144	2	28475860
Pubmed	Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains.	CACNA1D CACNA1S	1.70e-05	2	144	2	28978442
Pubmed	Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury.	DICER1 HPRT1	1.70e-05	2	144	2	20360310
Pubmed	Calcyphosine-like (CAPSL) is regulated in Multiple Symmetric Lipomatosis and is involved in Adipogenesis.	CAPSL SIRT1	1.70e-05	2	144	2	31186450
Pubmed	Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer.	DICER1 PRKCA	1.70e-05	2	144	2	25752336
Pubmed	Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice.	TRAF6 SIRT1	1.70e-05	2	144	2	32253651
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	1.70e-05	2	144	2	29325037
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	1.70e-05	2	144	2	15185077
Pubmed	Enhancing CD8 T-cell memory by modulating fatty acid metabolism.	TRAF6 CBLB	1.70e-05	2	144	2	19494812
Pubmed	Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.	KMT2B KMT2D	1.70e-05	2	144	2	35506254
Pubmed	[The expression of genes encoding the voltage-dependent L-type Ca2+ channels in proliferating and differentiating C2C12 myoblasts of mice].	CACNA1D CACNA1S	1.70e-05	2	144	2	21789999
Pubmed	A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence.	MAGEA3 MAGEA6	1.70e-05	2	144	2	25564441
Pubmed	PKCalpha regulates phosphorylation and enzymatic activity of cPLA2 in vitro and in activated human monocytes.	PLA2G4A PRKCA	1.70e-05	2	144	2	16963226
Pubmed	Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.	DICER1 KMT2D	1.70e-05	2	144	2	26841698
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	POLE GON4L DIDO1 DICER1 ASH2L XAB2 MADD FREM2 ARHGEF40 DNAJC10 PLCB3 IQGAP3	1.81e-05	650	144	12	38777146
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2B ASH2L KMT2D	1.93e-05	13	144	3	21502505
Pubmed	Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.	TRAF6 UBE4B CBLB	2.45e-05	14	144	3	29326975
Pubmed	Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.	FNBP1 KMT2B FMN1	2.45e-05	14	144	3	8605874
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	ZCCHC8 USP9X ZMYM2 ZDBF2 CHD7 CORO1B IQGAP3 ZNF687	2.46e-05	282	144	8	23667531
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TRAF6 UBE4B ZCCHC8 USP9X CORO1C LARS1 NARS1 ZMYM2 NCAPH2 MED13L XAB2 MADD ZNF592 EIF2AK1 DNAJB2 ALKBH6 MED13	2.50e-05	1285	144	17	35914814
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2B CXXC1 ASH2L KMT2D	3.07e-05	43	144	4	33472061
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZCCHC8 USP9X ZMYM2 ZDBF2 CHD7 FNBP1L SIRT1 NFATC2IP HPRT1 IQCB1 CEP170B	3.62e-05	588	144	11	38580884
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CBLL1 WWOX UBE4B MYO10 USP9X NARS1 ZDBF2 NCAPH2 MED13L DICER1 ASH2L SIRT1 XAB2 KMT5B ATG9A EIF2AK1 MED13	3.74e-05	1327	144	17	32694731
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	KMT2B CXXC1 ASH2L	3.74e-05	16	144	3	23870121
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2B ASH2L KMT2D	3.74e-05	16	144	3	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2B ASH2L KMT2D	4.53e-05	17	144	3	26180087
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	CBLL1 DDIT4 OBSCN GON4L DIDO1 CHD1L ZBTB1 HERC2P3 FREM2 AARS2 RWDD1 TNK2 PLCB3 TOR1AIP1 MED13 CEP170B	4.64e-05	1215	144	16	15146197
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FNBP1 ZCCHC8 USP9X ZMYM2 DIDO1 SIRT1 NFATC2IP PLA2G4A PRKCA ZNF687	5.00e-05	503	144	10	16964243
Pubmed	Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLCγ1-PKCα signaling pathway.	TRPM2 PRKCA	5.09e-05	3	144	2	23629676
Pubmed	Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).	CHD7 KMT2D	5.09e-05	3	144	2	28007623
Pubmed	Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.	CORO1C CORO1B	5.09e-05	3	144	2	22364218
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1D CACNA1S	5.09e-05	3	144	2	17767505
Pubmed	Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.	DICER1 HPRT1	5.09e-05	3	144	2	22969435
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1D CACNA1S	5.09e-05	3	144	2	2173707
Pubmed	The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation.	INTU HPRT1	5.09e-05	3	144	2	29581513
Pubmed	Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.	CACNA1D CACNA1S	5.09e-05	3	144	2	17289261
Pubmed	Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.	KMT2B KMT2D	5.09e-05	3	144	2	32544095
Pubmed	Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.	USP9X MARK4	5.09e-05	3	144	2	18254724
Pubmed	The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.	KMT2B KMT2D	5.09e-05	3	144	2	23358417
Pubmed	Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins.	FNBP1 FNBP1L	5.09e-05	3	144	2	16326391
Pubmed	miR-31 from adipose stem cell-derived extracellular vesicles promotes recovery of neurological function after ischemic stroke by inhibiting TRAF6 and IRF5.	TRAF6 IRF5	5.09e-05	3	144	2	33460643
Pubmed	Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.	CORO1B PRKCA	5.09e-05	3	144	2	16027158
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2B ASH2L KMT2D	5.42e-05	18	144	3	17500065
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2B CXXC1 ASH2L KMT2D	5.60e-05	50	144	4	37974198
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	ZCCHC8 KRI1 DIDO1 CHD7 CXXC1 ASH2L KMT2D AARS2 PURA	5.65e-05	410	144	9	26949251
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	FNBP1 KMT2B CORO1C LARS1 NARS1 ZMYM2 DIDO1 CHD7 MED13L SIRT1 KMT2D HPRT1 DYNC1LI1 DDX41 ZNF687	5.67e-05	1103	144	15	34189442
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INTU ZCCHC8 BCL7C PHRF1 DICER1 ZNF768 SIRT1 ARHGEF40 DNAJC10 KMT5B ZNF592 MARK4 DDX41 CEP170B ZNF687	6.46e-05	1116	144	15	31753913
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PHRF1 OBSCN GON4L ZDBF2 ARHGEF10L	6.53e-05	101	144	5	10997877
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	FNBP1 USP9X CORO1C DOK2 CBLB DICER1 TNK2 PCDH1	6.97e-05	327	144	8	15592455
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	GALNT15 DDIT4 ZMYM2 GON4L ADGRV1 CXXC1 PAIP1 SIRT1 ANKRD13C NRK ATG9A EIF2AK1	7.18e-05	750	144	12	11230166
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2B ASH2L KMT2D	7.53e-05	20	144	3	19047629
Pubmed	A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors.	CACNA1D NFASC FYCO1	7.53e-05	20	144	3	35224516
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	USP9X LARS1 NARS1 ZMYM2 DIDO1 NCAPH2 XAB2 NFATC2IP	7.75e-05	332	144	8	32786267
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	NYAP2 USP9X CORO1C ZDBF2 CORO1B MADD GRAMD1B HPRT1 PURA KNDC1 DYNC1LI1 PRKCA MRPL3 DNAJB2 CEP170B	8.11e-05	1139	144	15	36417873
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	UBE4B ZCCHC8 ZMYM2 DIDO1 XAB2 KMT2D DDX41 ZNF687	9.32e-05	341	144	8	32971831
Pubmed	The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.	BCL7C PHRF1 SIRT1 ZNF592	9.39e-05	57	144	4	21555454
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2B KMT2D	1.02e-04	4	144	2	19221051
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1D CACNA1S	1.02e-04	4	144	2	20937870
Pubmed	The coronin family of actin-associated proteins.	CORO1C CORO1B	1.02e-04	4	144	2	10461187
Pubmed	Degradation of AMPK by a cancer-specific ubiquitin ligase.	MAGEA3 MAGEA6	1.02e-04	4	144	2	25679763
Pubmed	Activation of interferon regulatory factor 5 by site specific phosphorylation.	TRAF6 IRF5	1.02e-04	4	144	2	22412986
Pubmed	FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.	MED13L MED13	1.02e-04	4	144	2	29809150
Interaction	TOP3B interactions	DGCR2 KMT2B UBE4B MYO10 POLE SPEG LARS1 OBSCN IRF5 FYCO1 CORO1B MED13L TESK1 BABAM2 PAIP1 MADD ARHGEF10L ARHGEF40 KMT2D GRTP1 ZNF592 MARK4 TNK2 ATG9A ALKBH6 IQGAP3 MED13 CEP170B ZNF687 ARAP1	1.38e-07	1470	144	30	int:TOP3B
Interaction	H2BC8 interactions	KMT2B CWC27 BCL7C ZMYM2 GON4L DIDO1 CHD7 CHD1L ARHGAP11A BABAM2 CXXC1 ZNF768 ASH2L NFATC2IP ZNF592 TOR1AIP1 ZNF687	8.06e-07	576	144	17	int:H2BC8
GeneFamily	PHD finger proteins	KMT2B PHRF1 DIDO1 CXXC1 ASH2L KMT2D	9.94e-06	90	99	6	88
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC10 DNAJC5 DNAJB2 DNAJC5B	1.48e-04	49	99	4	584
GeneFamily	WD repeat domain containing\|Coronins	CORO1C CORO1B	6.12e-04	7	99	2	495
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B KMT2D KMT5B	8.42e-04	34	99	3	487
GeneFamily	Zinc fingers CXXC-type	KMT2B CXXC1	1.89e-03	12	99	2	136
Coexpression	MULLIGHAN_NPM1_SIGNATURE_3_UP	TRAF6 ZMYM2 ARHGAP11A ZNF768 ARHGEF40 NFATC2IP KMT5B PURA RWDD1 PLA2G4A PLCB3 DNAJB2	3.32e-07	335	143	12	M10277
Coexpression	PEREZ_TP53_TARGETS	INTU MYO10 ZCCHC8 PHRF1 OBSCN DIDO1 IRF5 FYCO1 ADGRV1 GRAMD1B ARHGEF40 GRTP1 LZTS1 NRK MARK4 KNDC1 DNAJC5 RIMBP2 MAPK13 CEP170B ARAP1	2.36e-06	1201	143	21	M4391
Coexpression	WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	DGCR2 SPEG KRI1 DIDO1 CORO1B FNBP1L ZBTB7B BABAM2 DICER1 ARHGEF40 GRTP1 HPRT1 IQCB1 PRKCA DNAJC5	2.67e-06	646	143	15	M2419
Coexpression	WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	DGCR2 SPEG KRI1 DIDO1 CORO1B FNBP1L ZBTB7B BABAM2 DICER1 ARHGEF40 GRTP1 HPRT1 IQCB1 PRKCA DNAJC5	4.53e-06	675	143	15	MM1073
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	KMT2B UBE4B MYO10 USP9X POLE CHD7 PRKCA MED13	6.84e-06	180	143	8	M8239
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INTU TRAF6 NYAP2 RTL5 FMN1 DNAJC5B CEP170B	1.04e-06	163	144	7	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	mild-Lymphocytic-CD4_T_cells_3\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CCR10 CACNA1S ZDBF2 CORO1B F5 HERC2P3 DNAH8	1.18e-06	166	144	7	f8f8423423d72f0ea0266b59126abb27beb23094
ToppCell	VE-Treg-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	CCR10 ZDBF2 DOK2 CORO1B F5 MAPK13 DNAH8	2.70e-06	188	144	7	fa88ceb336e30de3585e62608527a0d44df74190
ToppCell	VE-Treg\|VE / Condition, Cell_class and T cell subcluster	CCR10 ZDBF2 DOK2 CORO1B F5 MAPK13 DNAH8	2.70e-06	188	144	7	ef048517dfe2fc995d13eb1f08106a487354a4cc
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RTL5 TRPM2 CXXC1 FMN1 ATG9A IQGAP3 RCN3	2.89e-06	190	144	7	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	TRAF6 BCL7C PHRF1 PURA DNAJB2 SRRM3 PCDH1	4.06e-06	200	144	7	0f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	POLE NCAPH2 ARHGAP11A CBLB CEP89 IQGAP3	1.37e-05	160	144	6	1a9329d8183296f36928bd9e96f10db9f04ce326
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Up 200; 10uM; HL60; HG-U133A	UBE4B DIDO1 CHD1L BABAM2 CRY2 DNAJC10 ATG9A CEP170B	3.45e-05	196	143	8	1982_UP
Drug	Hydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT_HG-U133A	KMT2B GON4L IRF5 CXXC1 TNK2 PLCB3 ATG9A TOR1AIP1	3.45e-05	196	143	8	2119_DN
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A	IRF5 NCAPH2 MARK4 TNK2 PLCB3 EIF2AK1 DNAJB2 ARAP1	3.45e-05	196	143	8	3251_DN
Drug	Azlocillin sodium salt [37091-65-9]; Down 200; 8.2uM; MCF7; HT_HG-U133A	CACNA1D SLC24A3 IRF5 BABAM2 CD22 PLCB3 MAPK13 CEP170B	3.45e-05	196	143	8	3468_DN
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	TRAF6 XAB2 CRY2 CD22 ZNF358 PLCB3 CEP170B RCN3	3.57e-05	197	143	8	3862_DN
Drug	Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; HL60; HT_HG-U133A	NOL3 FYCO1 TESK1 GRAMD1B MARK4 PRKCA MAPK13 DNAJB2	3.57e-05	197	143	8	2909_DN
Drug	alpha-estradiol; Up 200; 0.01uM; PC3; HT_HG-U133A	WWOX CHD7 NCAPH2 ZBTB1 CRY2 ZNF358 CYP7B1 CEP170B	3.57e-05	197	143	8	1210_UP
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; PC3; HT_HG-U133A	DGCR2 KMT2B UBE4B SPEG ZMYM2 TULP3 DCLRE1C EIF2AK1	3.70e-05	198	143	8	5807_DN
Drug	Norethynodrel [68-23-5]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CACNA1D KRI1 SLC24A3 IRF5 NCAPH2 GRTP1 PLCB3 EIF2AK1	3.70e-05	198	143	8	7471_UP
Drug	Flecainide acetate [54143-56-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	DGCR2 TRAF6 IRF5 NCAPH2 TULP3 ZNF358 MARK4 TNK2	3.70e-05	198	143	8	3843_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	DGCR2 DIDO1 XAB2 TULP3 CRY2 MAPK13 DNAJB2 CEP170B	3.70e-05	198	143	8	1650_DN
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	DGCR2 LARS1 IRF5 ARHGAP11A MADD DNAJB2 TOR1AIP1 ARAP1	3.70e-05	198	143	8	6239_DN
Drug	Meropenem [96036-03-2]; Down 200; 10.4uM; PC3; HT_HG-U133A	DGCR2 TRAF6 NOL3 KRI1 NCAPH2 MADD MARK4 CYP7B1	3.84e-05	199	143	8	5824_DN
Drug	S(-)-terguride hydrogen maleate [37686-85-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	ZMYM2 GON4L PODXL2 CHD7 MADD NFATC2IP CD22 ARAP1	3.84e-05	199	143	8	4633_DN
Drug	Calciferol [50-14-6]; Down 200; 10uM; MCF7; HT_HG-U133A	FNBP1 CACNA1D KMT2B MYO10 NCAPH2 TULP3 CEP170B ARAP1	3.84e-05	199	143	8	5346_DN
Drug	Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; HL60; HT_HG-U133A	WWOX ARHGEF10L TULP3 CD22 PRKCA PLCB3 CEP170B ARAP1	3.84e-05	199	143	8	1280_DN
Drug	Thioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A	DGCR2 TRPM2 SLC24A3 PODXL2 GRTP1 PRKCA PCDH1 ARAP1	3.98e-05	200	143	8	5270_UP
Disease	neuronal ceroid lipofuscinosis 4 (implicated_via_orthology)	DNAJC5 DNAJC5B	2.30e-05	2	142	2	DOID:0110720 (implicated_via_orthology)
Disease	testosterone measurement	GALNT15 CACNA1D NYAP2 WWOX NHSL2 TRPM2 BCL7C SLC24A3 CHD7 SSR2 ZBTB7B GRAMD1B SHROOM4 ARHGEF40 KNDC1 PRKCA RIMBP2 ARAP1	4.28e-05	1275	142	18	EFO_0004908
Disease	Wallerian Degeneration	UBE4B SIRT1	1.37e-04	4	142	2	C0043020
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1D CACNA1S	1.37e-04	4	142	2	DOID:0060173 (implicated_via_orthology)
Disease	ESOPHAGEAL CANCER	WWOX LZTS1	2.28e-04	5	142	2	133239
Disease	total glycated albumin	PRKCA RCN3	2.28e-04	5	142	2	EFO_0009305
Disease	Malignant tumor of esophagus	WWOX LZTS1	2.28e-04	5	142	2	cv:C0546837
Disease	Benign neoplasm of esophagus	WWOX LZTS1	3.41e-04	6	142	2	C0153942
Disease	cytochrome c oxidase subunit 6C measurement	F5 PRKCA	3.41e-04	6	142	2	EFO_0801515
Disease	Carcinoma in situ of esophagus	WWOX LZTS1	3.41e-04	6	142	2	C0154059
Disease	Esophageal carcinoma	WWOX LZTS1	4.75e-04	7	142	2	C0152018
Disease	Manic	CACNA1D TRPM2 ZNF592 DNAH8	5.56e-04	78	142	4	C0338831
Disease	Experimental Autoimmune Encephalomyelitis	CBLB SIRT1	8.10e-04	9	142	2	C0014072
Disease	Alzheimer disease, fasting blood glucose measurement	MADD CRY2	8.10e-04	9	142	2	EFO_0004465, MONDO_0004975
Disease	Asthma, Occupational	PLA2G4A PRKCA	1.01e-03	10	142	2	C0264423
Disease	Congenital small ears	CHD7 FREM2 KMT2D	1.02e-03	41	142	3	C0152423
Disease	creatinine measurement	CACNA1S INTU NYAP2 SPEG OBSCN ADGRV1 CBLB BABAM2 GRTP1 CEP89 ZNF592 TNK2 HCRTR2	1.07e-03	995	142	13	EFO_0004518
Disease	electrocardiography	CWC27 SPEG PXDC1 OBSCN DOK2 ZBTB7B ZNF592 ZNF358 PRKCA	1.10e-03	530	142	9	EFO_0004327
Disease	albuminuria	NYAP2 CWC27 CHD7 FMN1	1.12e-03	94	142	4	EFO_0004285
Disease	Adenocarcinoma of large intestine	POLE NRK MARK4 PRKCA	1.21e-03	96	142	4	C1319315
Disease	hearing impairment	COL11A2 CHD7 ADGRV1 BSND	1.31e-03	98	142	4	C1384666
Disease	urate measurement	NYAP2 POLE GON4L FNBP1L ADGRV1 BABAM2 CXXC1 CEP89 KMT5B FMN1 PLA2G4A PLCB3	1.34e-03	895	142	12	EFO_0004531
Disease	severe acute respiratory syndrome, COVID-19	WWOX CWC27 USP9X TRPM2 NFASC PRKCA RIMBP2 EIF2AK1	1.50e-03	447	142	8	EFO_0000694, MONDO_0100096
Disease	blood urea nitrogen measurement	GON4L IRF5 ADGRV1 SIRT1 PLA2G4A TNK2 DNAJC5B HCRTR2	1.60e-03	452	142	8	EFO_0004741
Disease	esophageal cancer (is_implicated_in)	WWOX LZTS1	1.73e-03	13	142	2	DOID:5041 (is_implicated_in)
Disease	attempted suicide	MYO7B FYCO1 GRTP1 DNAH8 HCRTR2	1.74e-03	178	142	5	EFO_0004321
Disease	urinary albumin to creatinine ratio	CACNA1S NYAP2 CWC27 CHD7 CCDC97	1.78e-03	179	142	5	EFO_0007778
Disease	body mass index, fasting blood glucose measurement	MADD CRY2 ARAP1	1.92e-03	51	142	3	EFO_0004340, EFO_0004465
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	DNAJC5 DNAJC5B	2.01e-03	14	142	2	DOID:14503 (implicated_via_orthology)
Disease	free androgen index	CACNA1D NYAP2 UBE4B CHD7 GRAMD1B PRKCA RIMBP2	2.29e-03	374	142	7	EFO_0007005
Disease	unipolar depression, response to escitalopram, response to citalopram, mood disorder	SLC24A3 CORO1B	2.32e-03	15	142	2	EFO_0003761, EFO_0004247, EFO_0006329, EFO_0007871
Disease	body mass index, type 2 diabetes mellitus	NYAP2 ARAP1	2.64e-03	16	142	2	EFO_0004340, MONDO_0005148
Disease	uric acid measurement	INTU NYAP2 FNBP1L ADGRV1 F5 FMN1 HPRT1 MARK4 HCRTR2	2.86e-03	610	142	9	EFO_0004761
Disease	cholesteryl esters to total lipids in large HDL percentage	NYAP2 MADD PLCB3	2.91e-03	59	142	3	EFO_0022248
Disease	colorectal health	GALNT15 WWOX ADGRV1 CBLB BABAM2	2.94e-03	201	142	5	EFO_0008460
Disease	body fat percentage, type 2 diabetes mellitus	NYAP2 ARAP1	2.98e-03	17	142	2	EFO_0007800, MONDO_0005148
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B MED13	2.98e-03	17	142	2	DOID:0060307 (is_implicated_in)
Disease	squamous cell carcinoma (is_implicated_in)	WWOX LZTS1	3.35e-03	18	142	2	DOID:1749 (is_implicated_in)
Disease	age at menopause	GALNT15 NYAP2 DIDO1 CHD7 BABAM2 ASH2L	3.50e-03	302	142	6	EFO_0004704
Disease	cystathionine measurement	DOK2 ANKRD13C	3.73e-03	19	142	2	EFO_0010474
Disease	Systemic Scleroderma	IRF5 SIRT1	3.73e-03	19	142	2	C0036421
Disease	peripheral neuropathy, response to docetaxel trihydrate	NYAP2 TRPM2	3.73e-03	19	142	2	EFO_0003100, GO_1902519
Disease	Omenn Syndrome	CHD7 DCLRE1C	3.73e-03	19	142	2	C2700553
Disease	cognitive function measurement	GALNT15 CACNA1D DDIT4 NYAP2 WWOX CORO1C PXDC1 ZDBF2 CHD7 KMT2D NFATC2IP FMN1 RIMBP2 PCDH1 ARAP1	3.90e-03	1434	142	15	EFO_0008354
Disease	obesity (implicated_via_orthology)	MED13L SIRT1 TULP3 PLCB3 MED13	3.92e-03	215	142	5	DOID:9970 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	KMT2B CHD7 KMT2D	4.53e-03	69	142	3	DOID:1682 (implicated_via_orthology)
Disease	Profound Mental Retardation	ZCCHC8 ZMYM2 GON4L MED13L	4.64e-03	139	142	4	C0020796
Disease	Mental Retardation, Psychosocial	ZCCHC8 ZMYM2 GON4L MED13L	4.64e-03	139	142	4	C0025363
Disease	Mental deficiency	ZCCHC8 ZMYM2 GON4L MED13L	4.64e-03	139	142	4	C0917816
Disease	Non-alcoholic Fatty Liver Disease	SIRT1 PRKCA EIF2AK1	4.72e-03	70	142	3	C0400966
Disease	Nonalcoholic Steatohepatitis	SIRT1 PRKCA EIF2AK1	4.72e-03	70	142	3	C3241937

Protein segments in the cluster

Peptide	Gene	Start	Entry
DFYEPRRPEDDDPTE	ALKBH6	136	Q3KRA9
TFPALEEDVIYDDVP	ARHGEF10L	121	Q9HCE6
GDEEDAYSAEPLPEL	CCR10	16	P46092
YEEEGPELAPEAEGR	ARHGEF40	1016	Q8TER5
SEEEEAPPDGAVAEY	CWC27	346	Q6UX04
EILDDDYPEGPEEFS	ADGRV1	4336	Q8WXG9
DGSIFTIPDDYKEDP	ANKRD13C	521	Q8N6S4
DDLYPDTAGPEAALE	CORO1B	361	Q9BR76
LYPDTAGPEAALEAE	CORO1C	361	Q9ULV4
DDEEEPDPYGFIVQT	CEP170B	1306	Q9Y4F5
DDDDVFPPYVLRPDD	DICER1	606	Q9UPY3
VPEEDFYVSPEDLEE	DNAJC5B	146	Q9UF47
GEFDREDEDPEYKPT	CHD7	1846	Q9P2D1
PDYPDVEEGGSAIIF	IQCA1	316	Q86XH1
LGLTSDDEDYVPPDD	GRAMD1B	226	Q3KR37
PPPAYDDVAQDEDDF	TNK2	631	Q07912
DPEEDYPKFGLLDQD	ASH2L	246	Q9UBL3
IADLYSAEPGEEEPA	RCN3	226	Q96D15
SLEEPDIRDPSEFEY	FMN1	1006	Q68DA7
DLGPTADYVFPDLTE	PODXL2	111	Q9NZ53
DEPEGVAALSLYDSP	DOK2	346	O60496
PEEDEDEQGESYTPR	MADD	781	Q8WXG6
EDELGYDDDFPVAVE	MED13L	256	Q71F56
PLEVDLEGADIPYED	LZTS1	576	Q9Y250
EEEGPSTFPDLESEF	MAGEA3	91	P43357
EEEGPSTFPDLESEF	MAGEA6	91	P43360
FEDGQELESPKEEYP	GRXCR2	36	A6NFK2
DYRPPDDAVFDIITD	FYCO1	1271	Q9BQS8
YDDDFEDDFIPLPPA	KMT5B	841	Q4FZB7
VPDKDDEPIFYFGDV	FREM2	2001	Q5SZK8
DSSYPPDAGLSDDEE	FAM89B	141	Q8N5H3
IRDFQEYVEPGEDFP	DYNC1LI1	191	Q9Y6G9
DYDLLIPPLGEDAFD	CBLB	801	Q13191
AEDEGEEYSPLEGLP	GALNT15	71	Q8N3T1
YFDEEEPEDAPSPEL	CCDC97	326	Q96F63
DTPLDIDIAGDPEYE	PCDH1	831	Q08174
LEDVLEELTYGPAPD	PCED1A	121	Q9H1Q7
DAPEEEIIPDGYNDS	DNAH8	3841	Q96JB1
YQDPTPGEEEEILES	COL11A2	291	P13942
QPYPEEEVDEGFEAD	MYO10	986	Q9HD67
DLPSPDGDYDYDQDD	MYO10	1081	Q9HD67
DPYELDPFDSSEELS	PHRF1	436	Q9P1Y6
PFFEPFRDPEEETEA	MAPK13	306	O15264
PVFEPGDKTFEEYLD	KRI1	491	Q8N9T8
YDIFEDSDDSEPGGP	KMT2B	1086	Q9UMN6
DIEDFEFTPKPEYEG	POLE	316	Q07864
QPPEDYSFGAGEEEE	IRF5	131	Q13568
PEEDPLDTFLQYIED	NYAP2	11	Q9P242
EDEDDEDYVPYVPLR	DDX41	26	Q9UJV9
PEGEETEFYVSPEDL	DNAJC5	141	Q9H3Z4
VPEPEERFAVDEYSD	IQGAP3	1256	Q86VI3
EDEDDDEGPYTPFDT	SLC24A3	426	Q9HC58
AGDPYLDDIDDEMDP	PAIP1	446	Q9H074
SDDEPGYDLDLFCIP	HPRT1	11	P00492
PPGDEEGFDYNEEER	CBLL1	56	Q75N03
LPGDPSSQEEDEDYD	INTU	16	Q9ULD6
EAPEFPGEAVSEDEY	OBSCN	5676	Q5VST9
YEDVFEEPSESGSDP	PTPN20	66	Q4JDL3
GPYVLGPADREDEEE	PLCB3	546	Q01970
LGPEDPKEEDGSFDY	NFASC	1256	O94856
EPFLNPTDYDDEEFL	HCRTR2	26	O43614
DEDLPLDPDLYQDFC	CXXC1	281	Q9P0U4
EEPEKEEEDLYYGLP	BSND	286	Q8WZ55
ELLEAEAPEAYPVFE	BCL7C	171	Q8WUZ0
EEEDDYLFDDPLPIP	DCLRE1C	386	Q96SD1
EFDDEFEDDDPLPAI	FNBP1L	526	Q5T0N5
PPDFIFGEDAEFLPD	BABAM2	81	Q9NXR7
FDSPYDKDGLVTPEE	CAPSL	166	Q8WWF8
DETYGVPSLEELGFP	CRY2	206	Q49AN0
AIDFPAEGPDPEYDE	EIF2AK1	26	Q9BQI3
ATDFDDEFDDEEPLP	FNBP1	536	Q96RU3
YPSADFPGDDEEDEP	CACNA1S	736	Q13698
PEEDTAYLDGVSLPD	DDIT4	66	Q9NX09
PSFETLDYGDEEDIE	CEP89	116	Q96ST8
DPFAELFDDLGPFSE	DNAJB2	111	P25686
EDPDDEGFPSHLLYS	CDHR3	261	Q6ZTQ4
LEASYSDSPPGEEDL	ATG9A	11	Q7Z3C6
RIDPYGFERPEDFDD	GRTP1	11	Q5TC63
EPLNFPDPEYKEEEE	CENPJ	1131	Q9HC77
YLFDGVEPEPFEVGD	CHD1L	326	Q86WJ1
EPPLDFPDTLEGFEY	FAM172A	51	Q8WUF8
DPEYNFLEDLDEPDT	GON4L	556	Q3T8J9
DDRPYDPEEEYDPER	DIDO1	1381	Q9BTC0
DPEEEYDPERAFDTQ	DIDO1	1386	Q9BTC0
FYDPADDDAFEPVEV	DGCR2	461	P98153
YATEEGFAPPEDDEI	MAPRE3	256	Q9UPY8
GEELKPYTEPEEDFG	MARK4	316	Q96L34
SVDPEEDGYPLTVAD	FIBCD1	356	Q8N539
PGEDAEEFYNELLPS	IQCB1	96	Q15051
FYDFEPLPTLPEDEE	KNDC1	21	Q76NI1
PSEEEDFGDPRTYDP	SLC44A5	11	Q8NCS7
HGDPEIFEAPEEFRY	CYP7B1	401	O75881
DFGIYDDDPEIITLE	DNAJC10	121	Q8IXB1
EDYDSGPDEDGELEP	SAMD15	6	Q9P1V8
DDYREEDEDKDPYPP	CACNA1D	806	Q01668
DYENVIPDFPEDEGI	CD22	806	P20273
ADPDEFERIYEPLDV	PLA2G4A	526	P47712
FPTYFPDGDEEELPE	MRPL3	316	P09001
PDGDEEELPEDLYDE	MRPL3	321	P09001
IQPPEEDGDYVELYD	NRK	911	Q7Z2Y5
DPGTEETYGEVEEEP	RTL5	441	Q5HYW3
GDEPDLDPDINKDFF	USP9X	706	Q93008
TPSLEGFEEGEYETP	ARHGAP11A	261	Q6P4F7
YEESETDPGAEELPA	RIMBP2	836	O15034
ERPDLVFEEEDLPYE	XAB2	11	Q9HCS7
EGAEPGLEYAPFDDD	SRRM3	121	A6NNA2
GLEYAPFDDDDGPVD	SRRM3	126	A6NNA2
PSELEDGDDPAAYVT	PXDC1	201	Q5TGL8
DFEDPYEDAESRLEP	SHD	41	Q96IW2
PGEELEADTEYLDPF	SHD	96	Q96IW2
TFYEFGEDIPEAPER	NARS1	411	O43776
PDDDEDSYEIFEPPE	F5	686	P12259
PPFDGEDEDELFQSI	PRKCA	536	P17252
ESPEYAEEPRAEEVF	NHSL2	846	Q5HYW2
YGCPPDFPDEEEEEE	LARS1	111	Q9P2J5
YSLEDEEEFDHLPPP	SLAIN1	321	Q8ND83
EEFYNGLEDEPDVPE	SIRT1	696	Q96EB6
EAEEEEEELPPQYFS	SHROOM4	1151	Q9ULL8
TGPEYEALDALPDAE	NOL3	41	O60936
DGLEEYLAEDPEPQE	SWSAP1	96	Q6NVH7
LEDYFPDSENPEVGG	HERC2P3	901	Q9BVR0
QEPKIDPYAFVEGDE	MED13	691	Q9UHV7
LYPPGDEEEAELADS	NFATC2IP	146	Q8NCF5
YFDGDPKAGLDPDLE	AARS2	171	Q5JTZ9
RLFPEFDDSDYDEVP	ARAP1	221	Q96P48
FDDSDYDEVPEEGPG	ARAP1	226	Q96P48
DDFLEPEEYMEPEGA	NCAPH2	436	Q6IBW4
DVELSDDSFPPEDFG	SSR2	56	P43308
YFGDLELFEPFDHPE	ZCCHC8	6	Q6NZY4
EPYEGEEEEEELVYP	ZBTB7B	271	O15156
EEEEEELVYPPAYGL	ZBTB7B	276	O15156
EVRFSDEPPEVYGDF	TOR1AIP1	56	Q5JTV8
YVSAGEEPLEAPVFE	SPEG	711	Q15772
FYEDATEFEGLVPEP	SLC26A1	521	Q9H2B4
PTGSFPAEYILDEDG	TRPM2	256	O94759
DSDLYDADGYDVPDP	WDR97	16	A6NE52
EEIQGYDVEFDPPLE	TRAF6	51	Q9Y4K3
AEIDYSDAPDEFRDP	UBE4B	1221	O95155
TPDFDDLLAAFDIPD	ZNF592	6	Q92610
SGDYEVEEIPFGLEP	ZNF768	46	Q9H5H4
VPGDSDYEVISDDIP	ZDBF2	1531	Q9HCK1
YAGLDDTDSEDELPP	WWOX	6	Q9NZC7
ADPDYLPRTEDFGLD	TESK1	256	Q15569
TDNDELEDEPEEPFY	ZBTB1	356	Q9Y2K1
NEFLLPPVFGEEYEE	ZMYM2	1021	Q9UBW7
TPDFDDLLAAFDIPD	ZNF687	6	Q8N1G0
EEDGYQGEDPESPFT	TCHHL1	526	Q5QJ38
LELEDDEDDPDYNPA	RWDD1	221	Q9H446
IDDYGVEEEPAELPE	PURA	206	Q00577
LLGDIDDLEDFVYSP	TULP3	181	O75386
YEDLEPVSEDLDPDA	ZNF358	61	Q9NW07
ELEYPFGAKGDSDPE	KMT2D	956	O14686
PEEDVDGLAEYTFPK	MYO7B	961	Q6PIF6