Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	FLNA LILRA2 NEO1 SIRPB1 SIRPA CAMTA1 ALPK2 MFAP3L	4.63e-03	663	74	8	2.60.40.10
Domain	S100_CABP	TCHHL1 FLG2	5.10e-03	27	74	2	PS00303
Domain	S_100	TCHHL1 FLG2	5.10e-03	27	74	2	PF01023
Domain	S100_Ca-bd_sub	TCHHL1 FLG2	5.48e-03	28	74	2	IPR013787
Domain	S_100	TCHHL1 FLG2	5.48e-03	28	74	2	SM01394
Domain	IG	LILRA2 NEO1 SIRPB1 SIRPA ALPK2 MFAP3L	6.46e-03	421	74	6	SM00409
Domain	Ig_sub	LILRA2 NEO1 SIRPB1 SIRPA ALPK2 MFAP3L	6.46e-03	421	74	6	IPR003599
Domain	Ig-like_fold	FLNA LILRA2 NEO1 SIRPB1 SIRPA CAMTA1 ALPK2 MFAP3L	6.71e-03	706	74	8	IPR013783
Domain	Ig_E-set	FLNA ARRDC1 CAMTA1	8.17e-03	104	74	3	IPR014756
Domain	PyrdxlP-dep_Trfase_major_sub2	PDXDC1 MOCOS	8.94e-03	36	74	2	IPR015422
Domain	SERPIN	SERPINA1 SERPINA2	9.43e-03	37	74	2	SM00093
Domain	SERPIN	SERPINA1 SERPINA2	9.43e-03	37	74	2	PS00284
Domain	Serpin	SERPINA1 SERPINA2	9.93e-03	38	74	2	PF00079
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF462 FLNA ZFHX4 ZNF592 TET1 SEC16A XRN1 PLEKHA5 ZDBF2 LRBA	4.40e-08	418	80	10	34709266
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 FLNA SERBP1 MDN1 POP1 PPIP5K1 LRBA FLG2	7.12e-08	234	80	8	36243803
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	PDXDC1 FLNA SERBP1 CISD1 SEC16A XRN1 ZDBF2 PRR14L LRBA LYSMD3	7.37e-07	568	80	10	37774976
Pubmed	Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase.	LILRA2 SIRPB1 SIRPA	1.91e-06	11	80	3	20145200
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	ZNF462 DAP3 MDN1 ZFHX4 POP1 SEC16A ZDBF2	4.10e-06	282	80	7	23667531
Pubmed	Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.	APBB2 APP	5.23e-06	2	80	2	18650440
Pubmed	Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.	SERPINA1 SERPINA2	5.23e-06	2	80	2	8227051
Pubmed	Mechanisms of alpha1-antitrypsin inhibition of cellular serine proteases and HIV-1 protease that are essential for HIV-1 morphogenesis.	SERPINA1 SERPINA2	5.23e-06	2	80	2	12878320
Pubmed	A conserved sequence in the T-cell receptor beta-chain promoter region.	TRBV12-4 TRBV12-3	5.23e-06	2	80	2	3259318
Pubmed	The T cell receptor from an influenza-A specific murine CTL clone.	TRBV12-4 TRBV12-3	5.23e-06	2	80	2	2784852
Pubmed	Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort.	TCHHL1 FLG2	5.23e-06	2	80	2	34984527
Pubmed	Interaction between superantigen and T-cell receptor Vbeta element determines levels of superantigen-dependent cell-mediated cytotoxicity of CD8(+) T cells in induction and effector phases.	TRBV12-4 TRBV12-3	5.23e-06	2	80	2	19659929
Pubmed	HIV-1 proprotein processing as a target for gene therapy.	SERPINA1 SERPINA2	5.23e-06	2	80	2	12621451
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	SEMG2 FLNA SERBP1 XRN1	7.52e-06	54	80	4	25631074
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	PDXDC1 NEO1 BMP2K SEC16A XRN1 APBB2 GPATCH4 LRBA FLG2 PPL	1.18e-05	777	80	10	35844135
Pubmed	SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.	SIRPB1 SIRPA	1.57e-05	3	80	2	36202053
Pubmed	Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes.	SIRPB1 SIRPA	1.57e-05	3	80	2	15034021
Pubmed	Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen.	SIRPB1 SIRPA	1.57e-05	3	80	2	26222253
Pubmed	The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.	APBB2 APP	1.57e-05	3	80	2	11544248
Pubmed	Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.	SIRPB1 SIRPA	1.57e-05	3	80	2	12167615
Pubmed	Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.	SIRPB1 SIRPA	1.57e-05	3	80	2	31507080
Pubmed	Involvement of signal regulatory protein α, a negative regulator of Toll-like receptor signaling, in impairing the MyD88-independent pathway and intracellular killing of Burkholderia pseudomallei-infected mouse macrophages.	SIRPB1 SIRPA	1.57e-05	3	80	2	22988019
Pubmed	Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain.	SIRPB1 SIRPA	1.57e-05	3	80	2	22468987
Pubmed	Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.	SIRPB1 SIRPA	1.57e-05	3	80	2	34917090
Pubmed	Effect of Serum Deprivation Stress on Signal Induction Regulatory Protein-Alpha (SIRP-Alpha)-Mediated Erythrophagocytosis by Macrophages.	SIRPB1 SIRPA	1.57e-05	3	80	2	30894504
Pubmed	Inhibitory regulation of osteoclast bone resorption by signal regulatory protein alpha.	SIRPB1 SIRPA	1.57e-05	3	80	2	19667119
Pubmed	Analysis of the T cell receptor (TcR) regions in the NOD, NON and CTS mouse strains define new TcR V alpha haplotypes and new deletions in the TcR V beta region.	TRBV12-4 TRBV12-3	1.57e-05	3	80	2	1532150
Pubmed	SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors.	SIRPB1 SIRPA	1.57e-05	3	80	2	28669759
Pubmed	SIRPα controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox).	SIRPB1 SIRPA	1.57e-05	3	80	2	23022485
Pubmed	Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.	SIRPB1 SIRPA	1.57e-05	3	80	2	29158380
Pubmed	Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells.	SIRPB1 SIRPA	1.57e-05	3	80	2	25817792
Pubmed	Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.	SIRPB1 SIRPA	1.57e-05	3	80	2	12134038
Pubmed	Central nervous system antigen P84 can serve as a substrate for neurite outgrowth.	SIRPB1 SIRPA	1.57e-05	3	80	2	2303162
Pubmed	SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages.	SIRPB1 SIRPA	1.57e-05	3	80	2	16141346
Pubmed	Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury.	SIRPB1 SIRPA	1.57e-05	3	80	2	31883525
Pubmed	Signal regulatory protein α is associated with tumor-polarized macrophages phenotype switch and plays a pivotal role in tumor progression.	SIRPB1 SIRPA	1.57e-05	3	80	2	23504854
Pubmed	SIRPα signaling regulates podocyte structure and function.	SIRPB1 SIRPA	1.57e-05	3	80	2	23842779
Pubmed	Essential roles of SIRPα in homeostatic regulation of skin dendritic cells.	SIRPB1 SIRPA	1.57e-05	3	80	2	20955735
Pubmed	A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.	SIRPB1 SIRPA	1.57e-05	3	80	2	17825046
Pubmed	SIRPα deficiency accelerates the pathologic process in models of Parkinson disease.	SIRPB1 SIRPA	1.57e-05	3	80	2	31322787
Pubmed	Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.	SIRPB1 SIRPA	1.57e-05	3	80	2	35634325
Pubmed	The Rho kinase pathway regulates the migration of dendritic cells through SIRP-α.	SIRPB1 SIRPA	1.57e-05	3	80	2	22391241
Pubmed	The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family.	SIRPB1 SIRPA	1.57e-05	3	80	2	9348339
Pubmed	Targeting SIRP-α protects from type 2-driven allergic airway inflammation.	SIRPB1 SIRPA	1.57e-05	3	80	2	21108471
Pubmed	Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.	SIRPB1 SIRPA	1.57e-05	3	80	2	16920950
Pubmed	Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation.	SIRPB1 SIRPA	1.57e-05	3	80	2	17109464
Pubmed	Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation.	SIRPB1 SIRPA	1.57e-05	3	80	2	23504624
Pubmed	Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice.	SIRPB1 SIRPA	1.57e-05	3	80	2	23472187
Pubmed	SIRP/CD47 signaling in neurological disorders.	SIRPB1 SIRPA	1.57e-05	3	80	2	25795378
Pubmed	Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.	SIRPB1 SIRPA	1.57e-05	3	80	2	25236797
Pubmed	Deficiency in SIRP-α cytoplasmic recruitment confers protection from acute kidney injury.	SIRPB1 SIRPA	1.57e-05	3	80	2	31370677
Pubmed	A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.	SIRPB1 SIRPA	1.57e-05	3	80	2	30770827
Pubmed	Signal regulatory protein α protects podocytes through promoting autophagic activity.	SIRPB1 SIRPA	1.57e-05	3	80	2	30888336
Pubmed	Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.	SIRPB1 SIRPA	1.57e-05	3	80	2	38758648
Pubmed	Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.	SIRPB1 SIRPA	1.57e-05	3	80	2	33795678
Pubmed	Requirement of SIRPα for protective immunity against Leishmania major.	SIRPB1 SIRPA	1.57e-05	3	80	2	20854790
Pubmed	Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.	SIRPB1 SIRPA	1.57e-05	3	80	2	17617577
Pubmed	BIT, an immune antigen receptor-like molecule in the brain.	SIRPB1 SIRPA	1.57e-05	3	80	2	9271230
Pubmed	Gene structure of mouse BIT/SHPS-1.	SIRPB1 SIRPA	1.57e-05	3	80	2	10585853
Pubmed	Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes.	SIRPB1 SIRPA	1.57e-05	3	80	2	18635660
Pubmed	Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.	SIRPB1 SIRPA	1.57e-05	3	80	2	29914984
Pubmed	SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.	SIRPB1 SIRPA	1.57e-05	3	80	2	11118207
Pubmed	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.	SIRPB1 SIRPA	1.57e-05	3	80	2	34050181
Pubmed	Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.	SIRPB1 SIRPA	1.57e-05	3	80	2	15123722
Pubmed	SIRPα+ dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes.	SIRPB1 SIRPA	1.57e-05	3	80	2	31099900
Pubmed	Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance.	SIRPB1 SIRPA	1.57e-05	3	80	2	33074246
Pubmed	Resistance to collagen-induced arthritis in SHPS-1 mutant mice.	SIRPB1 SIRPA	1.57e-05	3	80	2	18455510
Pubmed	Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.	SIRPB1 SIRPA	1.57e-05	3	80	2	26057870
Pubmed	Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.	SIRPB1 SIRPA	1.57e-05	3	80	2	18809435
Pubmed	Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function.	SIRPB1 SIRPA	1.57e-05	3	80	2	19223164
Pubmed	T cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments.	TRBV12-4 TRBV12-3	1.57e-05	3	80	2	3490968
Pubmed	Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages.	SIRPB1 SIRPA	1.57e-05	3	80	2	18233962
Pubmed	Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.	SIRPB1 SIRPA	1.57e-05	3	80	2	23559001
Pubmed	SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.	SIRPB1 SIRPA	1.57e-05	3	80	2	22671569
Pubmed	Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.	SIRPB1 SIRPA	1.57e-05	3	80	2	35511221
Pubmed	Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells.	SIRPB1 SIRPA	1.57e-05	3	80	2	17475843
Pubmed	Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.	APBB2 APP	1.57e-05	3	80	2	14527950
Pubmed	Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice.	SIRPB1 SIRPA	1.57e-05	3	80	2	12742627
Pubmed	Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs.	SIRPB1 SIRPA	1.57e-05	3	80	2	25818708
Pubmed	CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.	SERBP1 POP1 FLG2 PPL	2.37e-05	72	80	4	36123327
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	SERPINA1 NEO1 SPARCL1 SIRPB1 SIRPA APP	2.92e-05	257	80	6	16335952
Pubmed	SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.	SIRPB1 SIRPA	3.13e-05	4	80	2	35722884
Pubmed	Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.	SIRPB1 SIRPA	3.13e-05	4	80	2	22976304
Pubmed	Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.	SIRPB1 SIRPA	3.13e-05	4	80	2	34097709
Pubmed	TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells.	SIRPB1 SIRPA	3.13e-05	4	80	2	26907705
Pubmed	Down-regulation of platelet surface CD47 expression in Escherichia coli O157:H7 infection-induced thrombocytopenia.	SIRPB1 SIRPA	3.13e-05	4	80	2	19771158
Pubmed	Inflammation Unrestrained by SIRPα Induces Secondary Hemophagocytic Lymphohistiocytosis Independent of IFN-γ.	SIRPB1 SIRPA	3.13e-05	4	80	2	33028619
Pubmed	Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPα Facilitate Apoptotic Cell Clearance by Macrophages.	SIRPB1 SIRPA	3.13e-05	4	80	2	26085683
Pubmed	Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes.	TRBV12-4 TRBV12-3	3.13e-05	4	80	2	3470773
Pubmed	Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.	SIRPB1 SIRPA	3.13e-05	4	80	2	10477552
Pubmed	Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.	APBB2 APP	3.13e-05	4	80	2	8855266
Pubmed	'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47.	SIRPB1 SIRPA	3.13e-05	4	80	2	24143245
Pubmed	Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.	SIRPB1 SIRPA	3.13e-05	4	80	2	32294445
Pubmed	Polymorphism in the innate immune receptor SIRPα controls CD47 binding and autoimmunity in the nonobese diabetic mouse.	SIRPB1 SIRPA	3.13e-05	4	80	2	25305319
Pubmed	Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes.	SIRPB1 SIRPA	3.13e-05	4	80	2	21401967
Pubmed	SERPINA2 is a novel gene with a divergent function from SERPINA1.	SERPINA1 SERPINA2	3.13e-05	4	80	2	23826168
Pubmed	Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1.	SIRPB1 SIRPA	3.13e-05	4	80	2	14634079
Pubmed	CD47-signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction.	SIRPB1 SIRPA	3.13e-05	4	80	2	22042861
Pubmed	Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling.	SIRPB1 SIRPA	3.13e-05	4	80	2	16697668
Pubmed	An essential role for the association of CD47 to SHPS-1 in skeletal remodeling.	SIRPB1 SIRPA	3.13e-05	4	80	2	21638321
Interaction	YWHAG interactions	FLNA BNIP5 SERBP1 MDN1 MAST4 MLX RHPN2 MCFD2 STARD9 TET1 SEC16A PLEKHA5 PPIP5K1 LRBA APP DOP1A FARP2	3.04e-06	1248	76	17	int:YWHAG
Interaction	PHF21A interactions	FLNA ZFHX4 ZNF592 TET1 SEC16A XRN1 PLEKHA5 ZDBF2 LRBA	5.64e-06	343	76	9	int:PHF21A
Interaction	RCOR1 interactions	FLNA ZFHX4 ZNF592 ARRDC1 TET1 SEC16A XRN1 PLEKHA5 ZDBF2 LRBA	1.60e-05	494	76	10	int:RCOR1
GeneFamily	CD molecules\|V-set domain containing\|C1-set domain containing\|Signal regulatory proteins	SIRPB1 SIRPA	6.03e-05	5	45	2	747
GeneFamily	EF-hand domain containing\|S100 fused type protein family	TCHHL1 FLG2	1.26e-04	7	45	2	1350
GeneFamily	Serpin peptidase inhibitors	SERPINA1 SERPINA2	3.82e-03	37	45	2	739
GeneFamily	C1-set domain containing	SIRPB1 SIRPA	4.90e-03	42	45	2	591
GeneFamily	PDZ domain containing	MAST4 RHPN2 TIAM2	6.38e-03	152	45	3	1220
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NEO1 ALPK2 MFAP3L	7.48e-03	161	45	3	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TIAM2 FARP2	1.17e-02	66	45	2	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHA5 TIAM2 FARP2	1.46e-02	206	45	3	682
GeneFamily	T cell receptor beta locus at 7q34	TRBV12-4 TRBV12-3	1.98e-02	87	45	2	372
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC SERPINA1 LILRA2 TRPM2 SIRPB1 SIRPA DCSTAMP	7.20e-08	199	80	7	368e2bafae00ce8e9c6ea480f81b78f96b680acd
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TFEC SERPINA1 ZNF589 SIRPB1 SIRPA DNASE2	9.76e-07	183	80	6	103c4c4595d8daa677679fd2fa1e99cd398e56dd
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TFEC SERPINA1 LILRA2 BMP2K SIRPB1 SIRPA	1.59e-06	199	80	6	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ZNF462 FLNA ZFHX4 MINAR1 SPARCL1 APP	1.64e-06	200	80	6	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC BMP2K FMN1 TRPM2 SIRPA DCSTAMP	1.64e-06	200	80	6	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA SERPINA1 MAN2B2 SIRPB1 DNASE2	1.73e-05	178	80	5	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	PIK3CD-AS1 PDE8B ZDBF2 APP PPL	1.83e-05	180	80	5	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TFEC LILRA2 FMN1 TRPM2 SIRPA	2.37e-05	190	80	5	081b7bc07b6e5685e8a91b9ae6c1141623723700
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TFEC BMP2K FMN1 TRPM2 SIRPA	2.43e-05	191	80	5	24d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TFEC SERPINA1 LILRA2 SIRPA DCSTAMP	2.43e-05	191	80	5	79c83a710aa17fc06f286e4ea2011ed9e30e3bc6
ToppCell	PSB-critical-LOC-Myeloid-Neutrophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.49e-05	192	80	5	8dbdaa6a81767a866fb856f99ae35f9ee8064106
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.55e-05	193	80	5	d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TFEC BMP2K FMN1 TRPM2 SIRPA	2.55e-05	193	80	5	2d0dd2671ff27b922eb316f1ed0140353536ef30
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TFEC FMN1 TRPM2 SIRPA DCSTAMP	2.62e-05	194	80	5	ef30baa19b7aa97b61dea916fc2e0f5cf49848d6
ToppCell	PCW_07-8.5-Hematologic_Myeloid\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TFEC LILRA2 FMN1 TRPM2 SIRPA	2.62e-05	194	80	5	260649f5c4aeaa9cbf5ed5ae5e9f293d75bb0457
ToppCell	3'-Distal_airway-Immune_Myeloid\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA SERPINA1 PDE4DIP SIRPB1 SIRPA	2.68e-05	195	80	5	4df004b8ca7669a57d85c6dffef5b82b4ea1dfdf
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.68e-05	195	80	5	0110b976f98561ecd2e20ff6e7e3960a401bb7c2
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	MAST4 PDE4DIP MACROD2 PLEKHA5 ALPK2	2.68e-05	195	80	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA SERPINA1 PDE4DIP SIRPB1 SIRPA	2.68e-05	195	80	5	9e49e59a20b1bbd6167d594c33ab6bdfe2c1ebaf
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA SERPINA1 PDE4DIP SIRPB1 SIRPA	2.68e-05	195	80	5	412a9fcf9f075d97fae254bbd89774e4b1face07
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TFEC SERPINA1 LILRA2 TRPM2 SIRPA	2.68e-05	195	80	5	6c354c38ee2965d37152ffdc86ba929ba2049c6a
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TFEC LILRA2 FMN1 TRPM2 SIRPA	2.68e-05	195	80	5	518cc3baeb7cf2ad068692cbe85fd75be67f1872
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA SERPINA1 LILRA2 SIRPB1 DCSTAMP	2.68e-05	195	80	5	aa3914e277918299dc7d2995c0c72288462ad43d
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TFEC BMP2K FMN1 TRPM2 SIRPA	2.68e-05	195	80	5	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.68e-05	195	80	5	050fc59b328391d6e3ce23051764a842dcbb3144
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 ZFHX4 MACROD2 LRBA PPL	2.75e-05	196	80	5	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TFEC BNIP5 FMN1 TRPM2 SIRPA	2.75e-05	196	80	5	ce3709adbde7559b40c964888935914f66003247
ToppCell	NS-moderate-d_07-13-Myeloid\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLNA TFEC SERPINA1 SIRPB1 SIRPA	2.75e-05	196	80	5	e5c7ef2f092ad082698f014f9c5ba1ff4d07b93f
ToppCell	COVID-granulo1-\|COVID / Condition, Cell_class and T cell subcluster	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.82e-05	197	80	5	190392117dc6269a21983bd3e554066fd48acd5e
ToppCell	COVID-granulo1\|COVID / Condition, Cell_class and T cell subcluster	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.82e-05	197	80	5	4cd774d9d5a6bf7729dc6b7bcd3ddfe3f3051ada
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.82e-05	197	80	5	ec46aa307ce5774b4c0fcba64514f2d0cab3c4f9
ToppCell	390C-Myeloid-Monocyte-CD16+_Monocyte\|390C / Donor, Lineage, Cell class and subclass (all cells)	TFEC SERPINA1 LILRA2 PDE4DIP SIRPA	2.82e-05	197	80	5	01f5f5c34e904cc0146e978cc05ed1cd86a41533
ToppCell	COVID-19_Moderate-Classical_Monocyte\|COVID-19_Moderate / disease group, cell group and cell class	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.82e-05	197	80	5	98d4107e457e7399a84439acd73bf8f59598971b
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_monocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.82e-05	197	80	5	b91016249b3585aa3536e96af18e4f1b1d2d5ce4
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	d347462ba6cb1c5a59c86dffbbe914cbc1e9cf16
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	c5a22846bccff948f90bc1d5fe309907dcd08348
ToppCell	COVID-19_Mild-Myeloid-Classical_Monocyte\|COVID-19_Mild / Disease group, lineage and cell class	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	e78d027a095473af555762a4d542a73f5bb2e166
ToppCell	cellseq2-Immune-Immune_Myeloid-iMON-iMON\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	a6aa113f0af4d25c032f440c3134fe4d88ca5055
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	c49c71b34151d82b8795763bcb633c301c35f659
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TFEC SERPINA1 LILRA2 TRPM2 SIRPA	2.89e-05	198	80	5	898be90c906ebc806a764ae6c21bbf84649b6b30
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	4780f0276546962a2fc9f1041cfe49d2919d72b2
ToppCell	Control-Myeloid-Classical_Monocyte\|Control / Disease group, lineage and cell class	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	2b361d531c16e7a2d4cf676abb4421035d9bfe6e
ToppCell	cellseq2-Immune-Immune_Myeloid-iMON\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	2.89e-05	198	80	5	a0ceed8689d42be6b9cde89d6c182d10b3fb14fc
ToppCell	NS-moderate-d_16-33-Myeloid-Non-resident_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLNA TFEC SERPINA1 PDE4DIP SIRPA	2.89e-05	198	80	5	11a7a553de6786c1e8288251ba0d5c898505c158
ToppCell	distal-2-Hematologic-Interstitial_Macrophage\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNA TFEC FMN1 SIRPA PKDREJ	2.96e-05	199	80	5	d4caf296b6ce22a10b78d0efd4e018d867ccb78a
ToppCell	3'_v3-Lung-Myeloid_Mac\|Lung / Manually curated celltypes from each tissue	TFEC SERPINA1 PDE4DIP SIRPA DNASE2	2.96e-05	199	80	5	1677aaee5b7f5f262e27df5d9f1bdf6e21e3d804
ToppCell	cellseq2-Immune-Immune_Myeloid\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TFEC SERPINA1 LILRA2 BMP2K SIRPA	2.96e-05	199	80	5	6c3c9eceea20121ae17ae2462134aa0437f591b3
ToppCell	3'_v3-Lung-Myeloid_Mac-Alveolar_macrophages\|Lung / Manually curated celltypes from each tissue	TFEC SERPINA1 PDE4DIP SIRPA DNASE2	2.96e-05	199	80	5	eec1b086e5e8b9b0e1770dd269ca903f713d99a8
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	DNHD1 PPIP5K1 DCSTAMP FLG2 MFAP3L	2.96e-05	199	80	5	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	moderate-Myeloid-Non-resident_Macrophage\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNA TFEC SERPINA1 PDE4DIP SIRPA	2.96e-05	199	80	5	614c1e788d89310e78984241977941beed8d12dc
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC SERPINA1 SIRPB1 SIRPA DCSTAMP	3.03e-05	200	80	5	980cb0390586d8312890e8d0f3cf58e3309d16c5
ToppCell	COVID-19-COVID-19_Mild-Myeloid-CD14+_Monocyte\|COVID-19_Mild / Disease, condition lineage and cell class	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	3.03e-05	200	80	5	f76d3647f8ab5f7be018b0697c911597198e03f5
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC BMP2K FMN1 TRPM2 SIRPA	3.03e-05	200	80	5	77a68e8fd97a3f3467d25032067fd7ad52ab8522
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Macrophage_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC SERPINA1 SIRPB1 SIRPA DCSTAMP	3.03e-05	200	80	5	d7d971586c01152b3d21956fd98280588cb8f08b
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC SERPINA1 LILRA2 TRPM2 SIRPA	3.03e-05	200	80	5	3cfb28299a55fc1c150262a7333c59a48ae65ad1
ToppCell	severe-CD163+_Monocytes_(Sample_ID1_d7)\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TFEC SERPINA1 LILRA2 SIRPB1 SIRPA	3.03e-05	200	80	5	4943fe826d5fcc3dfeb8b99a7415848f3fecc994
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNA SERPINA1 LILRA2 TRPM2	9.98e-05	134	80	4	197599d26db97c4fe815f4812f6362e606fe347a
ToppCell	356C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	TFEC ZNF592 PCDHGA6 ZNF589	1.06e-04	136	80	4	edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell	356C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	TFEC ZNF592 PCDHGA6 ZNF589	1.06e-04	136	80	4	03e4e2353c23ceffde35b2d0aadd15299e3db09f
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-7\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	MAST4 STARD9 TET1 LRBA	1.35e-04	145	80	4	88090a226ddfa6df59976f025bf0fd84ca0f72ef
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	TFEC LILRA2 SIRPA DCSTAMP	1.75e-04	155	80	4	84221a285277292f7225eb69508c887541abeed1
ToppCell	VE-Treg-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	MAST4 PDE4DIP SIRPB1 PPL	1.79e-04	156	80	4	6501baf73616e702946de9fb13d267e30a68888b
ToppCell	COVID-19_Moderate-MAIT\|COVID-19_Moderate / disease group, cell group and cell class	ZNF462 PIK3CD-AS1 TRBV12-3 PLEKHA5	1.93e-04	159	80	4	6d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCell	COVID-19_Moderate-MAIT\|World / disease group, cell group and cell class	ZNF462 PIK3CD-AS1 TRBV12-3 PLEKHA5	1.97e-04	160	80	4	bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid\|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNA LILRA2 TRPM2 PDE4DIP	2.02e-04	161	80	4	1b5ebc82ee6166ecc2984648565f334cd69b636b
ToppCell	facs-Marrow-T_cells-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SIRPA APP MOCOS	2.27e-04	166	80	4	fab4da2537904ad114218f720e18a600f14a00a1
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	TFEC FMN1 TRPM2 PDE4DIP	2.49e-04	170	80	4	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium\|TCGA-Endometrium / Sample_Type by Project: Shred V9	ZCCHC24 PDE8B STARD9 SPARCL1	2.49e-04	170	80	4	cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal\|TCGA-Endometrium / Sample_Type by Project: Shred V9	ZCCHC24 PDE8B STARD9 SPARCL1	2.49e-04	170	80	4	0bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue\|TCGA-Endometrium / Sample_Type by Project: Shred V9	ZCCHC24 PDE8B STARD9 SPARCL1	2.49e-04	170	80	4	516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BNIP5 SERPINA1 RHPN2 ALPK2	2.60e-04	172	80	4	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BNIP5 SERPINA1 RHPN2 ALPK2	2.60e-04	172	80	4	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	Bronchial_Biopsy-Immune-Luminal_Macrophages\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	TFEC SERPINA1 SIRPB1 DCSTAMP	2.78e-04	175	80	4	1cf99de391552d4f8dbe2ed5b01fc3b8adca61b6
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFEC SERPINA1 SIRPA ALPK2	2.84e-04	176	80	4	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	FMN1 XRN1 PRR14L DNASE2	2.84e-04	176	80	4	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TFEC FMN1 SIRPA DCSTAMP	2.84e-04	176	80	4	98176bf3c961d5262593e2d5d002836adb010e13
ToppCell	ASK452-Epithelial-Secretory\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	MAST4 CISD1 MACROD2 FARP2	2.84e-04	176	80	4	dd334c8a8a31dc26b2d558df0ef6bed6dc1a6610
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MACROD2 PPIP5K1 GPATCH4 FARP2	2.84e-04	176	80	4	dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage\|GI_small-bowel / Manually curated celltypes from each tissue	TFEC SERPINA1 SIRPA DCSTAMP	2.84e-04	176	80	4	4be270f6bb7da4070f972aca403109751646d155
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SIRPA APP MOCOS	2.90e-04	177	80	4	065bebd22031f143e90a407f952b444a3f8818c7
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TFEC PCDHGA6 SIRPA ALPK2	2.90e-04	177	80	4	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	droplet-Spleen-nan-24m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TFEC SIRPA APP TIAM2	2.90e-04	177	80	4	5f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCell	facs-Marrow-Granulocytes-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA SIRPA APP MOCOS	2.90e-04	177	80	4	eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZNF462 PDE4DIP DCSTAMP PPL	2.96e-04	178	80	4	a28683690ab8a60eb18f3ef87ea85da4e95b22df
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TFEC LILRA2 TRPM2	3.08e-04	73	80	3	582faedb369a099d0acf1565413e6b3ca2cfc564
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 FMN1 PDE4DIP LRBA	3.09e-04	180	80	4	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	renal_papilla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ZFHX4 PDE4DIP LRBA PPL	3.09e-04	180	80	4	49829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCell	cellseq2-Immune-Immune_Myeloid-AM\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TFEC SERPINA1 DCSTAMP DNASE2	3.16e-04	181	80	4	d4ab8ab41bf3e6f1937e919662456d7c9551eeab
ToppCell	cellseq2-Immune-Immune_Myeloid-AM-AM\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TFEC SERPINA1 DCSTAMP DNASE2	3.16e-04	181	80	4	45fc9c27ea60312a118a2a6c1eb635d776fde295
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TFEC FMN1 TRPM2 SIRPB1	3.22e-04	182	80	4	ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 FMN1 PLEKHA5 LRBA	3.29e-04	183	80	4	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TFEC SERPINA1 SIRPA DCSTAMP	3.29e-04	183	80	4	745271bfe15e94a58157cd97d771e610f964341b
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TFEC FMN1 TRPM2 PKDREJ	3.29e-04	183	80	4	24679153b654c148dbd572e9013c0a6e58718ada
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	BMP2K MACROD2 XRN1 DOP1A	3.29e-04	183	80	4	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	Mesenchymal_cells-Osteoblasts\|Mesenchymal_cells / Lineage and Cell class	DDX59 P3H1 HRC FARP2	3.29e-04	183	80	4	d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ZNF462 SERPINA1 MAST4 ALPK2	3.36e-04	184	80	4	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	wk_08-11-Hematologic-Myeloid-DC3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TFEC SERPINA1 LILRA2 SIRPB1	3.36e-04	184	80	4	7d9294e5a55964903feda135e5bea0338824ed83
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERPINA1 LILRA2 SIRPA DCSTAMP	3.36e-04	184	80	4	ba260f8a2e6e510141a6b9c458eb0040acff0352
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TFEC SERPINA1 XRN1 SIRPA	3.43e-04	185	80	4	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 FMN1 PDE4DIP LRBA	3.43e-04	185	80	4	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
Disease	39S ribosomal protein L33, mitochondrial measurement	SERPINA1 SERPINA2	6.20e-06	2	74	2	EFO_0801332
Disease	level of tyrosine-protein phosphatase non-receptor type substrate 1 in blood serum	SIRPB1 SIRPA	6.20e-06	2	74	2	OBA_2040362
Disease	Vasculitis	SERPINA1 MOCOS	1.86e-05	3	74	2	C0042384
Disease	Manic Disorder	SERPINA1 ZNF592 STARD9 TRPM2	3.12e-05	71	74	4	C0024713
Disease	alpha globulin measurement, protein measurement	SERPINA1 SERPINA2	3.71e-05	4	74	2	EFO_0004747, EFO_0004813
Disease	Manic	SERPINA1 ZNF592 STARD9 TRPM2	4.52e-05	78	74	4	C0338831
Disease	Depression, Bipolar	SERPINA1 ZNF592 STARD9 TRPM2	4.75e-05	79	74	4	C0005587
Disease	synaptosomal-associated protein 25 measurement	SERPINA1 SERPINA2	6.17e-05	5	74	2	EFO_0021858
Disease	neuropeptide W measurement	SERPINA1 SERPINA2	9.25e-05	6	74	2	EFO_0801835
Disease	Degenerative Diseases, Central Nervous System	SERPINA1 PDE8B APP	1.30e-04	39	74	3	C0270715
Disease	Degenerative Diseases, Spinal Cord	SERPINA1 PDE8B APP	1.30e-04	39	74	3	C0751733
Disease	Neurodegenerative Disorders	SERPINA1 PDE8B APP	1.30e-04	39	74	3	C0524851
Disease	chymotrypsin-like elastase family member 2A measurement	SERPINA1 SERPINA2	2.21e-04	9	74	2	EFO_0802399
Disease	cognitive disorder (is_implicated_in)	APBB2 APP	2.21e-04	9	74	2	DOID:1561 (is_implicated_in)
Disease	signal-regulatory protein beta-1 measurement	SIRPB1 SIRPA	2.21e-04	9	74	2	EFO_0802069
Disease	alpha-1-antitrypsin measurement	SERPINA1 SERPINA2	2.21e-04	9	74	2	EFO_0008327
Disease	triacylglycerol 56:2 measurement	ZFHX4 MACROD2	3.36e-04	11	74	2	EFO_0010429
Disease	complement C1q tumor necrosis factor-related protein 1 measurement	SERPINA1 SERPINA2	4.03e-04	12	74	2	EFO_0801493
Disease	unipolar depression, autism spectrum disorder	SERPINA1 SERPINA2	6.38e-04	15	74	2	EFO_0003756, EFO_0003761
Disease	neuroimaging measurement, brain volume measurement	PDXDC1 MAST4 RHPN2 MACROD2 SERPINA2	7.71e-04	286	74	5	EFO_0004346, EFO_0006930
Disease	ectonucleoside triphosphate diphosphohydrolase 5 measurement	SERPINA1 SERPINA2	1.26e-03	21	74	2	EFO_0008115
Disease	neuroimaging measurement	PDXDC1 ZNF462 SERPINA1 NEO1 MAST4 RHPN2 CISD1 MACROD2 CAMTA1	1.39e-03	1069	74	9	EFO_0004346
Disease	red blood cell density measurement	PDXDC1 ZNF462 BMP2K FMN1 PDE8B CAMTA1 SERPINA2 FARP2	1.61e-03	880	74	8	EFO_0007978
Disease	necrotizing enterocolitis	MACROD2 TIAM2	2.09e-03	27	74	2	EFO_0003928
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	PDXDC1 SERPINA1 SEC16A LRBA	2.38e-03	222	74	4	EFO_0008317, EFO_0020943
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	PDXDC1 SERPINA1 SEC16A LRBA	2.50e-03	225	74	4	EFO_0008317, EFO_0020947

Protein segments in the cluster

Peptide	Gene	Start	Entry
PIEDDHGNSNSSHVK	CAMTA1	36	Q9Y6Y1
NHHGTAEEKSQPVQG	APBB2	181	Q92870
DQNGEEPFVKHEHEE	CCDC7	106	Q96M83
TPGDENEHAHFQKAK	APP	381	P05067
DTHNSTGQIHDVPEN	ALPK2	1556	Q86TB3
DPQGDAAQKTDTSHH	SERPINA1	26	P01009
QLGDGTPQHHQKSVE	DOP1A	881	Q5JWR5
ESKHGEGALDQPQHD	CCDC144CP	61	Q8IYA2
PQHLGKDHQESEEEE	DNHD1	2686	Q96M86
KVNVQECHAVGPEAH	BMP2K	906	Q9NSY1
VSKPDGFQEHVTATH	BBS12	246	Q6ZW61
HADVENQSGKDTSPV	ARRDC1	186	Q8N5I2
HHANIEALNEEGNTP	ANKRD19P	156	Q9H560
QQTGLSESHQDPEKH	FMN1	291	Q68DA7
QAERKDDSHPVHVDN	P3H1	576	Q32P28
ESALNHVQHPSGEAD	MRFAP1L1	76	Q96HT8
KEGEDEHPQRLNSHS	LILRA2	156	Q8N149
EQIVKAHQDNPHEGE	MLX	216	Q9UH92
QSNVTEETPEGEEHH	SERBP1	251	Q8NC51
GEEHHPVADTENKEN	SERBP1	261	Q8NC51
QAGSQHEEPEFTVHE	FLG2	1601	Q5D862
SHFSVDVQSEAHGPK	PCDHGA6	176	Q9Y5G7
VHPQSKKEHADDQEG	MFAP3L	321	O75121
GDAAQHPEEHSEEQQ	MDN1	4966	Q9NU22
IVPTKGIHFSQQDDH	LYSMD3	276	Q7Z3D4
AITHVHKEEGSEQAP	MCFD2	96	Q8NI22
QIHVNGSHSDHPEIN	KIAA2026	641	Q5HYC2
EVHSVSPEQGAKDSH	DDX59	71	Q5T1V6
KQDTHGVGHDPAKEF	GPATCH4	46	Q5T3I0
EEHNIFHNEVKAIGP	PPL	166	O60437
AFQKGVPHPEDDHSQ	PDXDC1	766	Q6P996
HKIHRDSGDNSQTEP	PDE8B	391	O95263
HGEKQGTQDIIHDSS	DCSTAMP	341	Q9H295
GTQVIHKQHPDPDSS	LRBA	796	P50851
SPEDEQKASHQHQEA	GOLGA6L1	106	Q8N7Z2
HSPEDEQKASHQHQE	GOLGA6L22	56	H0YM25
NVEGHDLPASEKHQD	MOCOS	871	Q96EN8
KTHQPSDEVGTSIEH	POP1	751	Q99575
DPQGDAAQKTDTSHH	SERPINA2	26	P20848
SPHATGHQQEEELKK	BNIP5	226	P0C671
AQEFPDLENVVKGHH	DNASE2	191	O00115
DLENVVKGHHVSQEP	DNASE2	196	O00115
EDPAGHQEEAKVTAN	FLNA	321	P21333
HHSVKAPKEDQAQEA	PIK3CD-AS1	136	Q5SR53
ESKHGEGALDQPQHD	CCDC144B	61	Q3MJ40
EVQHHDAITGTESPK	MAN2B2	416	Q9Y2E5
ADGFPEKQESHQKSH	MAST4	1541	O15021
EKQESHQKSHGPGSD	MAST4	1546	O15021
ESKHGEGALDQPQHD	CCDC144A	61	A2RUR9
LEFHQKHVGQTPAES	FARP2	201	O94887
ITPGTHASEHAVNKQ	CIAO2B	121	Q9Y3D0
SEGAKEDPHQHSTAA	PRR14L	136	Q5THK1
VHVQGNLTNPEDHKE	PRR14L	481	Q5THK1
VTEPHGEVNHNQKDL	PRR14L	1001	Q5THK1
GDKGNRPENTHHSEE	MINAR1	576	Q9UPX6
VTDHSVRDQDHPDGQ	MACROD2	316	A1Z1Q3
TNENDPAKHGDQHEG	DAP3	51	P51398
DDQDVHSEQHPSQKD	PKDREJ	1546	Q9NTG1
ISNVVHSKHNKPDEG	NEO1	111	Q92859
CQVEHDGQPAVSKSH	SIRPA	331	P78324
TIPSQDQEHGHKENK	SEMG2	451	Q02383
DHPDENKDVSTENGH	HRC	66	P23327
QVHASHTPGTDKELV	STARD9	2071	Q9P2P6
DHQVKPGTDLDHQEK	RHPN2	366	Q8IUC4
QVEHDGQPAVSKSHD	SIRPB1	331	Q5TFQ8
HASIHNEGDQPKTPE	TET1	846	Q8NFU7
AHTKHNEETGDNVGP	CISD1	86	Q9NZ45
SPEVSEGHENQHGQE	RNASEH1	76	O60930
PSIHFNDKDGDHDQS	ZFHX4	2826	Q86UP3
FQDNHGVTVGIKPEH	TIAM2	816	Q8IVF5
PDGNKANHSSHQEDT	SEC16A	976	O15027
EQHLEEATKPHTFQG	TRPM2	96	O94759
HENENIGTTEPGEHQ	SPARCL1	391	Q14515
QEHEQSGQNTVEPHK	ZNF592	216	Q92610
AKHTDAGVIQSPRHE	TRBV12-3	16	P01733
LVHGPQCHSENEAKE	XRN1	1481	Q8IZH2
ELHSRPHKSQEGTQE	ZDBF2	116	Q9HCK1
AKHTDAGVIQSPRHE	TRBV12-4	16	A0A0B4J2E0
HHSSQKATPAEEVED	ZNF462	2126	Q96JM2
VDLGAHVTKQQSHPE	TFEC	241	O14948
QQDPSHGEVGEHKDR	ZSCAN9	226	O15535
REAKTHNFPGEASEH	TCHHL1	161	Q5QJ38
HPSDKNHRGAEAEDQ	ZNF589	131	Q86UQ0
ETQTANHKPEEHPEE	PLEKHA5	1041	Q9HAU0
NHKPEEHPEENTKNS	PLEKHA5	1046	Q9HAU0
DQPSLNSHVAEEHQG	PPIP5K1	1196	Q6PFW1
DGLDVSDQSKEHPQH	ZCCHC24	211	Q8N2G6
TELVGSPGKHQHQEE	PDE4DIP	1151	Q5VU43
SPGKHQHQEEGNVTV	PDE4DIP	1156	Q5VU43