Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA2 DDX12P RNF213 MCM7 CHD7 DDX43 ATAD2 ATP13A2

9.94e-05441668GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

ABCA2 DDX12P RNF213 MCM7 CHD7 DDX43 ATAD2 ATP13A2 KIF24

1.80e-04614669GO:0140657
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCA2 RGS8 DDX12P RNF213 MCM7 CHD7 DDX43 ATAD2 ATP13A2 SAR1A

2.16e-047756610GO:0017111
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD4 RGS8 KALRN CDC42SE1 TBC1D2B RGPD1 DNMBP RASAL1

2.58e-04507668GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD4 RGS8 KALRN CDC42SE1 TBC1D2B RGPD1 DNMBP RASAL1

2.58e-04507668GO:0030695
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCA2 RGS8 DDX12P RNF213 MCM7 CHD7 DDX43 ATAD2 ATP13A2 SAR1A

4.06e-048396610GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCA2 RGS8 DDX12P RNF213 MCM7 CHD7 DDX43 ATAD2 ATP13A2 SAR1A

4.10e-048406610GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCA2 RGS8 DDX12P RNF213 MCM7 CHD7 DDX43 ATAD2 ATP13A2 SAR1A

4.10e-048406610GO:0016818
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 FKBP10 RGPD1

6.05e-0450663GO:0003755
GeneOntologyMolecularFunctionenzyme regulator activity

RGPD4 ABCA2 RGS8 RCAN1 KALRN CDC42SE1 TBC1D2B RGPD1 PRKAR2B SPRED1 DNMBP ZEB2 RASAL1

6.53e-0414186613GO:0030234
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 FKBP10 RGPD1

7.18e-0453663GO:0016859
GeneOntologyMolecularFunctionhelicase activity

DDX12P MCM7 CHD7 DDX43

1.86e-03158664GO:0004386
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD1

1.97e-0320662GO:0061665
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 RGS8 TBC1D2B RGPD1 RASAL1

2.29e-03279665GO:0005096
GeneOntologyMolecularFunctionphosphatidic acid binding

SESTD1 ATP13A2

2.83e-0324662GO:0070300
DomainPH_dom-like

RGPD4 JAK3 KALRN TBC1D2B RGPD1 SPRED1 OSBP2 RASAL1

1.11e-04426658IPR011993
DomainSpectrin/alpha-actinin

SESTD1 KALRN DSP

1.86e-0432653IPR018159
DomainSPEC

SESTD1 KALRN DSP

1.86e-0432653SM00150
DomainHIS_ACID_PHOSPHAT_2

ACP6 PXYLP1

2.48e-047652PS00778
DomainGCC2_Rab_bind

RGPD4 RGPD1

2.48e-047652IPR032023
DomainHIS_ACID_PHOSPHAT_1

ACP6 PXYLP1

2.48e-047652PS00616
DomainRab_bind

RGPD4 RGPD1

2.48e-047652PF16704
DomainHis_Pase_clade-2

ACP6 PXYLP1

3.29e-048652IPR000560
DomainHis_Phos_2

ACP6 PXYLP1

3.29e-048652PF00328
Domain-

RGPD4 KALRN TBC1D2B RGPD1 SPRED1 OSBP2 RASAL1

4.09e-043916572.30.29.30
Domain-

RGPD4 RGPD1

5.27e-04106521.10.220.60
DomainGrip

RGPD4 RGPD1

6.43e-0411652SM00755
DomainGRIP

RGPD4 RGPD1

6.43e-0411652PF01465
DomainP-loop_NTPase

TANC2 ABCA2 RNF213 MCM7 CHD7 DDX43 ATAD2 SAR1A KIF24 HYDIN

6.55e-048486510IPR027417
Domain-

RGPD4 TANC2 ATR P4HA1 RGPD1

7.67e-042076551.25.40.10
DomainRan_BP1

RGPD4 RGPD1

7.70e-0412652PF00638
DomainGRIP_dom

RGPD4 RGPD1

7.70e-0412652IPR000237
DomainGRIP

RGPD4 RGPD1

7.70e-0412652PS50913
DomainRANBD1

RGPD4 RGPD1

7.70e-0412652PS50196
DomainRanBD

RGPD4 RGPD1

9.08e-0413652SM00160
DomainRan_bind_dom

RGPD4 RGPD1

9.08e-0413652IPR000156
DomainTPR_repeat

RGPD4 TANC2 P4HA1 RGPD1

1.19e-03133654IPR019734
DomainTPR-like_helical_dom

RGPD4 TANC2 ATR P4HA1 RGPD1

1.30e-03233655IPR011990
DomainAAA+_ATPase

ABCA2 RNF213 MCM7 ATAD2

1.59e-03144654IPR003593
DomainAAA

ABCA2 RNF213 MCM7 ATAD2

1.59e-03144654SM00382
DomainTPR-contain_dom

RGPD4 TANC2 P4HA1 RGPD1

1.85e-03150654IPR013026
DomainHis_PPase_superfam

ACP6 PXYLP1

2.18e-0320652IPR029033
Domain-

ACP6 PXYLP1

2.18e-03206523.40.50.1240
DomainTPR_REGION

RGPD4 TANC2 P4HA1 RGPD1

2.62e-03165654PS50293
DomainTPR

RGPD4 TANC2 P4HA1 RGPD1

2.62e-03165654PS50005
DomainCRAL_TRIO

SESTD1 KALRN

3.96e-0327652PS50191
Domain-

ABCA2 RNF213 MCM7 CHD7 DDX43 ATAD2 SAR1A HYDIN

4.22e-037466583.40.50.300
DomainCRAL-TRIO_dom

SESTD1 KALRN

4.25e-0328652IPR001251
DomainSpectrin_repeat

KALRN DSP

4.56e-0329652IPR002017
DomainRNA-helicase_DEAD-box_CS

INTS6 DDX43

5.87e-0333652IPR000629
Pubmed

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

AMT ATR DSP CLPTM1 CHD7 WNT4 SAR1A ZEB2

2.78e-0733168820634891
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

INTS6 KALRN DSP PLA2G4B RNF213 CHST11 CHD7 KIF24 MSI2

1.28e-0655268910737800
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 JAK3 ABCA2 KALRN KCNG1 PLA2G4B PFAS DNMBP ATP13A2 REPIN1 NR2F2 RASAL1

1.41e-061105681235748872
Pubmed

Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria.

KALRN CHD7

3.77e-06268228152519
Pubmed

Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer.

ZEB2 PDZD2

3.77e-06268223184150
Pubmed

Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance.

ATAD2 KIF24

3.77e-06268224391143
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ATR DSP ATXN7 PARG CHD7 PATL1 ATAD2 DNMBP NR1D1

1.95e-0577468915302935
Pubmed

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.

ATR MCM7

2.25e-05468215538388
Pubmed

Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.

INTS6 MCM7

2.25e-05468217310990
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

INTS6 DSP P4HA1 STAU2 PKM MCM7 REPIN1 MSI2

4.15e-0565568835819319
Pubmed

The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.

STAU2 MSI2

5.62e-05668217768378
Pubmed

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

ATR MCM7

5.62e-05668215210935
Pubmed

Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.

ZEB2 NR2F2 CCN3

5.74e-053868331597102
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

FKBP10 NLN DSP P4HA1 CLPTM1 STAU2 PKM RNF213 PFAS MCM7 TBCA

6.50e-051367681132687490
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

FKBP10 DSP P4HA1 STAU2 PKM PRKAR2B PFAS MCM7 TBCA MSI2

7.60e-051149681035446349
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD1

7.86e-05768221205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD1

7.86e-05768218949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD1

7.86e-05768225187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD1

7.86e-0576829037092
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD1

7.86e-0576828603673
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD1

7.86e-05768215710750
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD1

7.86e-05768226632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD1

7.86e-05768224403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD1

7.86e-05768223818861
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD1

7.86e-05768211353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD1

7.86e-05768230944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD1

7.86e-05768238838144
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD1

7.86e-05768223536549
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD1

7.86e-0576827559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD1

7.86e-05768217372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD1

7.86e-05768238657106
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD1

7.86e-05768212191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD1

7.86e-05768222821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD1

7.86e-05768220682751
Pubmed

Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.

FKBP10 DSP MCM7 DNMBP TBCA

8.11e-0522568531478661
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD4 FKBP10 STAU2 RGPD1 PATL1

8.28e-0522668537839992
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

NLN INTS6 CLPTM1 PKM CHD7 KIF24 MSI2

8.55e-0553668715840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

NLN INTS6 CLPTM1 PKM CHD7 KIF24 MSI2

8.75e-0553868710512203
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD1

1.05e-04868222262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD1

1.05e-04868221670213
Pubmed

WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary.

WNT4 NR2F2

1.05e-04868226939755
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD1

1.05e-04868228745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD1

1.05e-04868227412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD1

1.05e-04868221310149
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD4 TANC2 SESTD1 KALRN RGPD1 PRKAR2B CHD7 ZEB2 RASAL1

1.05e-0496368928671696
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD1

1.34e-04968218394993
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD1

1.34e-04968211553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD1

1.34e-04968210601307
Pubmed

Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome.

RCAN1 PKM

1.34e-04968225261685
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD1

1.34e-0496829733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD1

1.34e-04968228100513
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD1

1.34e-04968228877029
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD1

1.34e-04968217887960
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD1

1.68e-04106828857542
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD1

1.68e-041068227160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD1

1.68e-041068216332688
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD1

1.68e-041068221859863
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD4 DSP RGPD1 MCM7 CHD7 ZEB2

1.70e-0441868634709266
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SESTD1 ABCA2 RCAN1 KALRN DSP PKM SPRED1 NR1D1 MGAT5B ZEB2

1.90e-041285681035914814
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD1

2.05e-041168235771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD1

2.05e-041168217069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD1

2.05e-041168234110283
Pubmed

Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.

P4HA1 WNT4

2.45e-041268226794322
Pubmed

An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.

AMT STAU2

2.45e-041268222902294
Pubmed

Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).

NR1D1 NR2F2

2.45e-041268216219912
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

RGPD4 DSP CLPTM1 RGPD1 PKM MCM7 SAR1A

2.71e-0464768726618866
Pubmed

Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).

FKBP10 DSP PLA2G4B

2.86e-046568332120844
Pubmed

Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads.

DSP WNT4

2.90e-041368235119382
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD1

2.90e-041368231427429
Pubmed

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.

WNT4 NR2F2

2.90e-041368235613264
Pubmed

High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.

DSP P4HA1 STAU2 PKM PATL1 MSI2

3.15e-0446968637314180
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

NLN KALRN PKM RNF213 ZEB2

3.28e-0430468532235678
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

TANC2 INTS6 KALRN DSP STAU2 PKM

3.37e-0447568631040226
Pubmed

FGFR2 mutation in 46,XY sex reversal with craniosynostosis.

SPRED1 WNT4

3.38e-041468226362256
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RGPD4 TANC2 KALRN DSP STAU2 RGPD1 PKM PRKAR2B RASAL1

3.65e-04113968936417873
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

DSP STAU2 MCM7 ATAD2 MSI2

3.86e-0431568526777405
Pubmed

CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression.

CHD7 WNT4

3.89e-041568237052590
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD1

3.89e-041568214697343
Pubmed

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

INTS6 STAU2

4.44e-041668221436445
Pubmed

Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control.

FKBP10 NR2F2

5.03e-041768233706013
Pubmed

Marker genes identify three somatic cell types in the fetal mouse ovary.

WNT4 NR2F2

5.03e-041768225158167
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

TANC2 INTS6 CLPTM1 STAU2 CHST11 URB2 SAR1A

5.09e-0471968735337019
Pubmed

Docking motif-guided mapping of the interactome of protein phosphatase-1.

SPRED1 MCM7 HYDIN

5.27e-048068319389623
Pubmed

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

ATR MCM7

5.65e-041868228191891
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ENOSF1 INTS6 ATXN7 SPACA6 RNF213 CHST11 PATL1 WNT4 MSI2 PDZD2

6.07e-041489681028611215
Pubmed

Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9.

WNT4 NR2F2

6.30e-041968232365547
Pubmed

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

DSP PKM PFAS MCM7

6.48e-0420068435546148
Pubmed

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.

ATXN7 DNMBP

7.00e-042068234127677
Pubmed

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.

WNT4 NR2F2

7.72e-042168231712577
Pubmed

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.

PFAS HYDIN

7.72e-042168226234751
Pubmed

Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes.

SPRED1 WNT4

7.72e-042168232452519
Pubmed

Identification of cellular proteins required for replication of human immunodeficiency virus type 1.

AMT KALRN

7.72e-042168222404213
Pubmed

Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.

DSP ZEB2

7.72e-042168224161570
Pubmed

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.

ATR MCM7

8.48e-042268215707391
Pubmed

Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid.

XDH NR2F2

8.48e-042268210753524
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD1

8.48e-042268227717094
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 P4HA1 RGPD1

9.80e-049968327746211
Pubmed

Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X.

TRPC3 PKM

1.01e-03246829722956
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DSP TBC1D2B PFAS MCM7 CHD7 DNMBP

1.03e-0358868638580884
Pubmed

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

PFAS MCM7

1.10e-032568227621311
CytobandEnsembl 112 genes in cytogenetic band chr15q25

TBC1D2B ADAMTSL3 CPEB1

1.76e-03160683chr15q25
Cytoband15q25.2

ADAMTSL3 CPEB1

1.88e-034368215q25.2
Cytoband3q23

ATR PXYLP1

1.96e-03446823q23
CytobandEnsembl 112 genes in cytogenetic band chr3q23

ATR PXYLP1

3.98e-0363682chr3q23
GeneFamilyClass II Cys-based phosphatases|Acid phosphatases

ACP6 PXYLP1

1.26e-0474521071
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

RGPD4 INTS6 RIMKLB TBC1D2B PKM CHST11 CHD7 REPIN1 ZEB2 NR2F2 TBCA MSI2

8.43e-0610096712M157
CoexpressionHORIUCHI_WTAP_TARGETS_UP

TANC2 KALRN RNF213 NR1D1 SAR1A ZEB2 PDZD2

1.40e-05309677M1973
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

TANC2 SESTD1 INTS6 RIMKLB ATR DSP PARG PRKAR2B DDX43 URB2 ATAD2 KIF24 CPEB1

1.42e-068206713gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

SESTD1 AMT RIMKLB ATR DSP PARG RNF213 PFAS DDX43 URB2 ATAD2 CPEB1

8.83e-068226712gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

RIMKLB ATR DDX43 ATAD2 CPEB1

1.94e-05104675gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k2_1000
ToppCellCOPD-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

TANC2 ENOSF1 KALRN DSP OSBP2 ADAMTSL3 NR2F2

2.00e-08195687e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCellP28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B WNT4 ADAMTSL3 ZEB2 NR2F2 PDZD2

3.82e-0718468623c24ab5786af33d605bc445d06117b9da6c6331
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 ZEB2 NR2F2 CPEB1 PDZD2

4.34e-07188686a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 SESTD1 RIMKLB RCAN1 SCTR MGAT5B

4.47e-071896868c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 SESTD1 RIMKLB RCAN1 SCTR MGAT5B

4.47e-071896865d902a4660a27548764bf04c6de152b565da835c
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 ZEB2 NR2F2 CPEB1 PDZD2

4.61e-07190686951e067d14412db67dc3babcdf61e41717d7b429
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 ZEB2 NR2F2 CPEB1 PDZD2

4.61e-071906867fec459cd2ad12c2923a03d098289337c0a4c1d3
ToppCellIPF-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

TANC2 KALRN DSP OSBP2 ADAMTSL3 NR2F2

5.37e-07195686de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCellControl-Endothelial-Lymphatic|Endothelial / Disease state, Lineage and Cell class

TANC2 KALRN DSP OSBP2 ADAMTSL3 NR2F2

5.54e-07196686e0cf617b0f5d9c3c19574f587a3d0ccbf93d8ca4
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TRPC3 SPRED1 ADAMTSL3 ZEB2 NR2F2 PDZD2

6.23e-07200686d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2|Neuronal / cells hierarchy compared to all cells using T-Statistic

ENOSF1 RGS8 SCTR CHD7 WNT4 NR2F2

6.23e-07200686501a3b93624df463458a35d3e6648d4ccc941724
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

ENOSF1 RGS8 SCTR CHD7 WNT4 NR2F2

6.23e-07200686d1f36a8232411933b1494168ec912fd0e5246428
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

6.24e-061706851f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

KALRN TRPC3 RNF213 OSBP2 CHD7

7.59e-0617768582fdd6185b368f54f03de389427cbe3071d21a99
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR CHD7 WNT4 NR2F2

7.59e-06177685d7976eac7e27044f6a859cc0c3398d08576e8c01
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

KALRN CLPTM1 PRKAR2B RASAL1 MSI2

8.24e-06180685289f8c4b53ffd164fee1f459a9315c0deb5f76d0
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR CHD7 WNT4 NR2F2

8.46e-06181685062f00736eed96e4f4327615d093558dd7d82b20
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKAR2B MCM7 ATAD2 NR1D1 KIF24

8.93e-0618368542dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ENOSF1 RGS8 SCTR CHD7 NR2F2

9.41e-061856850b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellLV-07._Pericyte|LV / Chamber and Cluster_Paper

KALRN ADAMTSL3 ZEB2 NR2F2 PDZD2

9.41e-06185685acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCellP15-Mesenchymal-developing_mesenchymal_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

9.66e-06186685db9b67066fc003c7995ec205d15176bf40c97add
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRPC3 TBC1D2B ADAMTSL3 NR2F2 PDZD2

9.66e-06186685888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KALRN TRPC3 PRKAR2B ADAMTSL3 NR2F2

9.91e-0618768586250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 RIMKLB SCTR HYDIN PDZD2

9.91e-06187685c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TRPC3 PRKAR2B ADAMTSL3 NR2F2 PDZD2

1.02e-05188685ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.04e-0518968526cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.07e-051906852ab604d35456beba71c25511e0f819000e6642d2
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.07e-051906857e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.07e-05190685979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCelltumor_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

KALRN DSP PRKAR2B RASAL1 MSI2

1.07e-0519068558a6ab70737d719ca9725ac087f20dfe9be0463e
ToppCellP07-Mesenchymal-developing_mesenchymal_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.10e-05191685ddbc5f97f2aef19be4ad93db4139876c939b848e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR CHD7 WNT4 NR2F2

1.10e-0519168506760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.10e-051916852ad717b59215ad8d933e9637d363b65d7298e5d4
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.13e-05192685430ef714bf2544d32f3fd96a55af010f79aa9be0
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

KALRN DSP PRKAR2B RASAL1 MSI2

1.13e-05192685f18da8db573e584c8b90df0814afcf020360108e
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK3 ABCA2 MCM7 REPIN1 MSI2

1.13e-0519268503dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR CHD7 WNT4 NR2F2

1.13e-051926856a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellP03-Mesenchymal-developing_mesenchymal_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PRKAR2B ADAMTSL3 ZEB2 NR2F2 PDZD2

1.13e-05192685063e119c4b58957643908f667e6cfd6f7517fd03
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLN DSP MCM7 REPIN1 MSI2

1.15e-051936855879efb38e6b3bf8c33c9a773632b1d726e3c153
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLN DSP MCM7 REPIN1 MSI2

1.15e-05193685725115a5ce3ef520b3ef469e96b8219b4c723fdd
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLN DSP MCM7 REPIN1 MSI2

1.15e-05193685abd7bcf318a2d895d8811c2ada8bfb4314fca3b1
ToppCellIPF-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

TRPC3 PRKAR2B ADAMTSL3 NR2F2 PDZD2

1.18e-051946853892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 PKM SCTR HYDIN RASAL1

1.27e-051976857e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCellControl-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SESTD1 RIMKLB MGAT5B ZEB2 MSI2

1.27e-05197685925bf0d38e4ce279fa45f455546ebd199282c0df
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ACP6 ATXN7 PFAS ATAD2 MGAT5B

1.37e-05200685691b3edf7d8449556e8bf611662eb85772959f0f
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TRPC3 ADAMTSL3 ZEB2 NR2F2 CCN3

1.37e-05200685b5b5a32925f225610fe25a021a742d6397162863
ToppCellParenchymal-10x3prime_v2-Stromal-Pericyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRPC3 PRKAR2B ADAMTSL3 NR2F2 PDZD2

1.37e-05200685d70bad979299615fcba707ba21296020918705e6
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3|Neuronal / cells hierarchy compared to all cells using T-Statistic

RGS8 SCTR CHD7 WNT4 NR2F2

1.37e-052006857e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCellParenchymal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRPC3 PRKAR2B ADAMTSL3 NR2F2 PDZD2

1.37e-0520068538c21ec379005f688df33aea65237a063c476c2e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ACP6 ATXN7 PFAS ATAD2 MGAT5B

1.37e-0520068536a110aa91a791fdf1142e7869e8aa0d342402d0
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

RGS8 SCTR CHD7 WNT4 NR2F2

1.37e-0520068548303e499251d6754cfa991dc2d96c5563b2123c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ACP6 ATXN7 PFAS ATAD2 MGAT5B

1.37e-052006854e077aa7faddcebdfc54667f8b3990704441005b
ToppCellBronchial-10x5prime-Stromal-Pericyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRPC3 PRKAR2B ADAMTSL3 NR2F2 PDZD2

1.37e-05200685362706445edb33b313684efe50b1f44f5f816e67
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

TRPC3 SCTR ADAMTSL3 ZEB2 NR2F2

1.37e-05200685cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ACP6 ATXN7 PFAS ATAD2 MGAT5B

1.37e-05200685d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH|Neuronal / cells hierarchy compared to all cells using T-Statistic

RGS8 SCTR CHD7 WNT4 NR2F2

1.37e-052006854802dd6cae84b41746227a5d1aa1c9b858495e36
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

TRPC3 ADAMTSL3 ZEB2 NR2F2 PDZD2

1.37e-05200685bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)|Neuronal / cells hierarchy compared to all cells using T-Statistic

RGS8 SCTR CHD7 WNT4 NR2F2

1.37e-0520068575649534a98bc738fca62d071de0978dc61eb24f
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_E|PND01-03-samps / Age Group, Lineage, Cell class and subclass

RGS8 PRKAR2B ADAMTSL3 PDZD2

5.44e-0513568435928195cf34f055b353562c96f451aef2344d64
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tmem163_Dmrtb1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNG1 TRPC3 TEKT1 WNT4

5.60e-051366840376c2907b869c7d42f57af7f65ffdd6246c4d27
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

JAK3 FKBP10 TEKT1 CPEB1

9.53e-0515668410d191e29b16cae8238e8df6c0ff38882253f34e
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA1 NR1D1 ZEB2 CPEB1

9.53e-05156684d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACP6 CLPTM1 PFAS MCM7

9.53e-05156684895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRPC3 ADAMTSL3 NR2F2 PDZD2

9.77e-05157684bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PARG MCM7 PXYLP1 ATAD2

1.05e-041606845cc1b75e3c20d83112b3aa2f3c749a6c73910a2d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_TNFAIP8L3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DSP KCNG1 WNT4 NR2F2

1.13e-041636847352c30c253f69f65dcb15f46f9c87719741b55b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RIMKLB SCTR HYDIN PDZD2

1.16e-041646841cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellfacs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC2 FKBP10 DNMBP NR2F2

1.24e-04167684961e722442d786ab15d1e490941d2be265a9057a
ToppCellfacs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC2 FKBP10 DNMBP NR2F2

1.24e-041676843760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCTR WNT4 ADAMTSL3 PDZD2

1.30e-041696842d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCTR WNT4 ADAMTSL3 PDZD2

1.30e-04169684ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCTR WNT4 ADAMTSL3 PDZD2

1.30e-04169684ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATR KALRN KCNG1 SPRED1

1.33e-04170684d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

TRPC3 PRKAR2B ADAMTSL3 NR2F2

1.36e-04171684080003f698f867935c2bfc55d241d3650f45a0ab
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPC3 ADAMTSL3 ATAD2 PDZD2

1.39e-0417268403a0aff6b7971093a4347b5ed12546d78374c56f
ToppCellmetastatic_Brain-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

KALRN PRKAR2B RASAL1 MSI2

1.39e-0417268438d17e769fe8eac8b57b820490d4ddd969243ee7
ToppCellfacs-BAT-Fat-3m-Myeloid-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SESTD1 NR1D1 ATP13A2 ZEB2

1.39e-041726845f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

KALRN DSP OSBP2 NR2F2

1.42e-04173684dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

TRPC3 PRKAR2B ADAMTSL3 NR2F2

1.42e-04173684fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B ADAMTSL3 NR2F2 PDZD2

1.48e-04175684fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 WNT4 ADAMTSL3 PDZD2

1.48e-04175684d2ff8fedca9039cbd45cfd9dec88f4edbe7fe4fc
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPC3 WNT4 ADAMTSL3 PDZD2

1.48e-041756842a53d4f140d5ab096efe8118d8aa351db7838b49
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 WNT4 ADAMTSL3 PDZD2

1.48e-04175684a7310950e8d51b3004ea3aee8ce9948fe8655112
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMT SCTR KIF24 RASAL1

1.48e-04175684c1a8a55af825d5913095f919fa860828df9c273e
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPC3 WNT4 ADAMTSL3 PDZD2

1.48e-04175684fb91a45763e4c48d993094a13088ffc19f1e2574
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMT SCTR KIF24 RASAL1

1.48e-0417568478b453e220218c84557f244ef7a760e4a1952761
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR CHD7 NR2F2

1.48e-041756845a9160a9d05e01d945e77fd81bb0bd87139545cd
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR WNT4 NR2F2

1.52e-041766840fb6b57c3fffc93c40f4989007af4d522666c5e9
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR WNT4 NR2F2

1.52e-0417668423f930dac5247ea6d4124da33933d61ad6e089af
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA1 PARG ZEB2 NR2F2

1.52e-04176684749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKAR2B MCM7 ATAD2 NR1D1

1.52e-04176684450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

KALRN RNF213 OSBP2 CHD7

1.52e-041766843de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPC3 WNT4 ADAMTSL3 PDZD2

1.52e-04176684e2b59a904c5c8f9c88e1e63788e9b6485f22edd0
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TRPC3 WNT4 ADAMTSL3 PDZD2

1.52e-04176684f931192e3cc65414e2245354f443473696cc7ce8
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR WNT4 NR2F2

1.55e-0417768484116796ca4c7007508c0f1a68a1135c7b922278
ToppCellCOVID-19-Heart-Lymph_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

KALRN OSBP2 ADAMTSL3 NR2F2

1.55e-04177684326fde0734ef0d7272693966d346ca479b9d8147
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPC3 ADAMTSL3 NR2F2 PDZD2

1.58e-04178684185b44700f06ec58b3c09c80520502166c965fd6
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RCAN1 PFAS ADAMTSL3 NR2F2

1.58e-041786845cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS8 SCTR WNT4 NR2F2

1.58e-041786842a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCellfacs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RCAN1 PFAS ADAMTSL3 NR2F2

1.58e-04178684f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
Diseaseportal hypertension (biomarker_via_orthology)

XDH NR1D1 CPEB1

1.52e-0522653DOID:10762 (biomarker_via_orthology)
Diseaselysophosphatidylcholine measurement

ENOSF1 PLA2G4B DDX43

3.52e-0462653EFO_0010224
Diseasespine bone size

WNT4 ADAMTSL3

7.15e-0418652EFO_0004508
DiseaseChronic myeloproliferative disorder

JAK3 ATR

7.98e-0419652C1292778
DiseaseOmenn Syndrome

JAK3 CHD7

7.98e-0419652C2700553
Diseaseetiocholanolone glucuronide measurement

TMPRSS11E XDH

7.98e-0419652EFO_0800362
Diseaseoptic disc size measurement

TANC2 SESTD1 ADAMTSL3 PDZD2

1.10e-03205654EFO_0004832
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor

CHST11 PDZD2

1.28e-0324652EFO_0003761, EFO_0005658
Diseaseacute kidney failure (implicated_via_orthology)

XDH WNT4

1.62e-0327652DOID:3021 (implicated_via_orthology)
Diseasehyperthyroidism (biomarker_via_orthology)

MCM7 NR1D1

1.74e-0328652DOID:7998 (biomarker_via_orthology)
Diseasehepatocellular carcinoma (biomarker_via_orthology)

XDH PFAS MCM7

1.77e-03108653DOID:684 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PLPIVRRTQCMMERM

URB2

561

Q14146
KRRRIDRTMIGEPMN

CDC42SE1

21

Q9NRR8
RDLEMCIERIMVPMQ

DNMBP

801

Q6XZF7
NEGKEMCVLRMTRAR

ATAD2

1286

Q6PL18
MCRRVCRMPVKPDDE

CHD7

2021

Q9P2D1
EEMERMRRPKPKIIQ

RCAN1

226

P53805
MELDPCKMDLGRTRR

RASAL1

381

O95294
EIRECMVMRDPTTKR

MSI2

46

Q96DH6
KVGMRREAVQRGRMP

NR2F2

141

P24468
GEPNMQGIPKRRRCM

INTS6

646

Q9UL03
RMMGCERDVPALCRL

JAK3

1036

P52333
QIMCIRKGKRMVARI

PATL1

586

Q86TB9
MRRCQIIRDMIGPEK

ENOSF1

231

Q7L5Y1
MITVNPDGKIMVRRC

MGAT5B

1

Q3V5L5
TPIEEMRRMPRCGIR

PARG

456

Q86W56
LMVRNGDPRIRMLEV

PDZD2

521

O15018
LVPKRCNDMMNLGRL

KALRN

2096

O60229
MEKIRVCVRKRPLGM

KIF24

221

Q5T7B8
KMMIGRCNRAGKPVI

PKM

311

P14618
LGRCMRRLRDMVERP

KCNG1

206

Q9UIX4
FMGQLMKRLPESRIC

PLA2G4B

481

P0C869
IMKNCIGRELSRIPM

OSBP2

526

Q969R2
KNREVMGLCREDMPI

ATXN7

121

O15265
PRGMKIRGNINICLM

MCM7

366

P33993
MLCRGEGIKMTPRRQ

P4HA1

291

P13674
GRIPKREKQRMLAEM

NR1D1

206

P20393
RDMVKLSMRVCVCRP

ATP13A2

286

Q9NQ11
CEVTMRLMRDQREPL

ATR

2536

Q13535
LMGMCVNERRRLIVP

FKBP10

106

Q96AY3
TRLMCRPQIIELLDM

HYDIN

66

Q4G0P3
EMLKQTRLCMVRPCE

CCN3

236

P48745
LDSLIREMRQMGQPC

DSP

121

P15924
RSLGENMIIRCMVPE

GJE1

151

A6NN92
QKRDLPQMMDEVGRI

DDX12P

696

Q92771
RTEMDEIRKNLGMCP

ABCA2

1056

Q9BZC7
FERLLGPCMEIMKRN

PRKAR2B

381

P31323
MSSRRMRCKEVQVIP

CPEB1

396

Q9BZB8
VQRRRVGLMCEGAPM

AMT

316

P48728
MKCPMLRSRLGQESV

C1orf127

1

Q8N9H9
ERLRICQMFVGMRSP

SPACA6

36

W5XKT8
REMERKMERPQGRPK

DDX43

631

Q9NXZ2
VNGKPRMLMRRDQVL

RGPD1

1076

P0DJD0
EVNGKPRMLMRREQV

RGPD4

1091

Q7Z3J3
PRMLMRREQVLKVCA

RGPD4

1096

Q7Z3J3
MPRRNKGMRTRLGCL

RGS8

6

P57771
RPMEVFMCSVLKRQG

SAR1A

171

Q9NR31
CPGTPEMRRRQEEAM

TANC2

431

Q9HCD6
DEVLCMQMRKSIPLR

TEKT1

386

Q969V4
MCPLENLVRFVKRDM

PXYLP1

446

Q8TE99
MLERRCRGPLAMGLA

REPIN1

1

Q9BWE0
RCEDMVDVRRLKMLQ

SESTD1

481

Q86VW0
IKMPVMYRIGCLRDD

CLPTM1

561

O96005
MKPALLEVMRMNRIC

CHST11

1

Q9NPF2
VMKKCCIPETRRRME

NLN

251

Q9BYT8
MMYRPDVVRARKRVC

TMPRSS11E

1

Q9UL52
DKLRIIMEQSMRCLP

RNF213

1776

Q63HN8
IEMRFRCGIPVIIMG

RNF213

2406

Q63HN8
ERGMPRRREFVMQVK

STAU2

331

Q9NUL3
RGERLRDKMVVLECM

SPRED1

61

Q7Z699
RGDPEMEQKMNRVIR

PFAS

486

O15067
PGRMVEVECPRFLRM

SCTR

81

P47872
MEKMRRPVLIIFCLC

TRAV7

1

A0A075B6U4
GRPVRCMLDRDEDML

XDH

821

P47989
SCPMLKRFARMIEQR

ACP6

266

Q9NPH0
EKMGCRLMNRPQAIL

RIMKLB

96

Q9ULI2
MCKRNLEVMDSVRRG

WNT4

56

P56705
MKQPIMADGPRCKRR

ZEB2

1

O60315
ILQESRMMIPDCQRR

TBCA

56

O75347
NREMMCSPELKNLIR

TBC1D2B

646

Q9UPU7
KCRRRRLQKDIEMGM

TRPC3

716

Q13507
AKGRRIPLSEMMCRD

ADAMTSL3

851

P82987