Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionD-dopachrome decarboxylase activity

DDT DDTL

2.48e-0521002GO:0033981
GeneOntologyMolecularFunctionphenylpyruvate tautomerase activity

DDT DDTL

7.42e-0531002GO:0050178
GeneOntologyMolecularFunctionintramolecular oxidoreductase activity, interconverting keto- and enol-groups

DDT DDTL

1.48e-0441002GO:0016862
GeneOntologyMolecularFunctionhydroperoxy icosatetraenoate dehydratase activity

PTGIS ALOXE3

5.13e-0471002GO:0106256
DomainMacrophage_inhib_fac

DDT DDTL

8.15e-053982PD004816
DomainMacrophage_inhib_fac_CS

DDT DDTL

8.15e-053982IPR019829
DomainTautomerase/MIF_sf

DDT DDTL

8.15e-053982IPR014347
DomainMIF

DDT DDTL

8.15e-053982PS01158
DomainMacrophage_inhib_fac

DDT DDTL

8.15e-053982IPR001398
DomainMIF

DDT DDTL

8.15e-053982PF01187
DomainDpy19

DPY19L2 DPY19L1

1.62e-044982PF10034
DomainDpy-19/Dpy-19-like

DPY19L2 DPY19L1

1.62e-044982IPR018732
DomainSpectrin

SPTBN2 SPTBN5 SYNE2

2.30e-0423983PF00435
DomainACTININ_2

SPTBN2 SPTBN5 SYNE2

2.30e-0423983PS00020
DomainACTININ_1

SPTBN2 SPTBN5 SYNE2

2.30e-0423983PS00019
DomainActinin_actin-bd_CS

SPTBN2 SPTBN5 SYNE2

2.30e-0423983IPR001589
DomainSpectrin_repeat

SPTBN2 SPTBN5 SYNE2

4.64e-0429983IPR002017
DomainSPEC

SPTBN2 SPTBN5 SYNE2

6.22e-0432983SM00150
DomainSpectrin/alpha-actinin

SPTBN2 SPTBN5 SYNE2

6.22e-0432983IPR018159
DomainZINC_FINGER_C2H2_2

ZXDC ZNF234 TRPS1 ADNP ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF654 ZNF639 ZNF239

7.37e-047759812PS50157
DomainZINC_FINGER_C2H2_1

ZXDC ZNF234 TRPS1 ADNP ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF654 ZNF639 ZNF239

7.53e-047779812PS00028
DomainZnf_C2H2-like

ZXDC ZNF234 TRPS1 ADNP ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF654 ZNF639 ZNF239

9.29e-047969812IPR015880
DomainPH_dom-spectrin-type

SPTBN2 SPTBN5

9.58e-049982IPR001605
DomainZnf_C2H2

ZXDC ZNF234 TRPS1 ADNP ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF654 ZNF639 ZNF239

1.02e-038059812IPR007087
DomainZnF_C2H2

ZXDC ZNF234 TRPS1 ADNP ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF654 ZNF639 ZNF239

1.06e-038089812SM00355
DomainCUB

CUBN CSMD3 ATRNL1

2.17e-0349983PF00431
DomainCUB

CUBN CSMD3 ATRNL1

2.30e-0350983SM00042
Domain-

CUBN CSMD3 ATRNL1

2.57e-03529832.60.120.290
DomainCUB

CUBN CSMD3 ATRNL1

2.71e-0353983PS01180
DomainPI3/4_kinase_CS

PIK3C2G MTOR

2.74e-0315982IPR018936
Domain-

PIK3C2G MTOR

3.12e-03169821.10.1070.11
DomainPI3Kc

PIK3C2G MTOR

3.12e-0316982SM00146
DomainCUB_dom

CUBN CSMD3 ATRNL1

3.34e-0357983IPR000859
Domainzf-C2H2

ZNF234 TRPS1 ADNP ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF639 ZNF239

3.44e-036939810PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZXDC ZNF234 ADNP ZXDB GTF3A ZNF394 GLI1 ZNF654 ZNF639 ZNF239

3.48e-036949810IPR013087
DomainPI3_PI4_kinase

PIK3C2G MTOR

3.95e-0318982PF00454
DomainPI3_4_KINASE_1

PIK3C2G MTOR

3.95e-0318982PS00915
DomainPI3_4_KINASE_2

PIK3C2G MTOR

3.95e-0318982PS00916
DomainPI3/4_kinase_cat_dom

PIK3C2G MTOR

3.95e-0318982IPR000403
DomainPI3_4_KINASE_3

PIK3C2G MTOR

3.95e-0318982PS50290
DomainCH

SPTBN2 SPTBN5 SYNE2

4.84e-0365983SM00033
Pubmed

Genetically engineered mouse models of brain cancer and the promise of preclinical testing.

LIG4 BRCA2 PTCH2

4.98e-0612100319076778
Pubmed

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.

MTOR ALK

8.18e-062100225228590
Pubmed

GLI1 overexpression promotes gastric cancer cell proliferation and migration and induces drug resistance by combining with the AKT-mTOR pathway.

MTOR GLI1

8.18e-062100230841479
Pubmed

Cloning of the mouse gene for D-dopachrome tautomerase.

DDT DDTL

8.18e-06210029858785
Pubmed

Distribution maps of D-dopachrome tautomerase in the mouse brain.

DDT DDTL

8.18e-062100223000624
Pubmed

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis.

MTOR CLN3

8.18e-062100216714284
Pubmed

The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study.

MTOR ALOXE3

8.18e-062100230678711
Pubmed

Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12.

MTOR GNA12

8.18e-062100233386590
Pubmed

Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer.

MTOR EEF2K

8.18e-062100229094413
Pubmed

ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

MYLK RYR1 BRCA2 MUTYH

2.26e-0557100423788249
Pubmed

"Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.

DDT DDTL

2.45e-053100235738135
Pubmed

RGS22 inhibits pancreatic adenocarcinoma cell migration through the G12/13 α subunit/F-actin pathway.

RGS22 GNA12

2.45e-053100226323264
Pubmed

Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.

DDT DDTL

2.45e-05310029716662
Pubmed

Genetic regulation of gene expression of MIF family members in lung tissue.

DDT DDTL

2.45e-053100233046825
Pubmed

Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer.

DDT DDTL

2.45e-053100237464010
Pubmed

Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids.

MTOR GLI1

2.45e-053100234126195
Pubmed

[Study on activation of AKT/mTOR pathway in anaplastic large cell lymphoma].

MTOR ALK

2.45e-053100219176054
Pubmed

Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.

DDT DDTL

2.45e-053100225016026
Pubmed

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

CDC7 BRCA2 MTOR DAAM1

3.81e-0565100427453043
Pubmed

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.

RGS22 GNA12

4.89e-054100218703424
Pubmed

Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase.

DDT DDTL

4.89e-054100218684922
Pubmed

Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain.

MTOR EEF2K

4.89e-054100216098202
Pubmed

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

DDT DDTL

4.89e-054100221817065
Pubmed

Cardiomyocyte d-dopachrome tautomerase protects against heart failure.

DDT DDTL

4.89e-054100231484822
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

ARHGEF28 BCAS3 SPTBN2 TRPS1 LMBR1 RAD9B CHD9 LIG4 GSE1 KIFC3 MUTYH

7.30e-059251001128986522
Pubmed

Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA?

LIG4 BRCA2

8.14e-055100223643835
Pubmed

Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.

DDT DDTL

8.14e-05510029729470
Pubmed

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback.

GLI1 PTCH2

8.14e-055100234353359
Pubmed

TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells.

DDT DDTL

8.14e-055100229924850
Pubmed

Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis.

BMP6 GLI1

8.14e-05510029486541
Pubmed

The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury.

DDT DDTL

8.14e-055100224983315
Pubmed

Regulation of apoptosis signal-regulating kinase 1 degradation by G alpha13.

ARHGEF28 GNA12

8.14e-055100217595347
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

SCG5 CA14 RRAD CUBN RYR1 RGL1 GTF3A THRB MTOR CLN3 DAAM1 MED27 ZNF639

8.63e-0512931001315342556
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PITPNM2 BCAS3 VPS13C TRPS1 ARHGEF38 LMBR1 CHD9 DDT TASOR2 THRB SMG7 CLK2 DAAM1 MED27

9.22e-0514891001428611215
Pubmed

Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.

GLI1 PTCH2

1.22e-046100219487286
Pubmed

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency.

LIG4 BRCA2

1.22e-046100219164512
Pubmed

Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.

LIG4 BRCA2

1.22e-046100228976792
Pubmed

MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.

DDT DDTL

1.22e-046100234850744
Pubmed

Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10.

DDT DDTL

1.22e-04610029628829
Pubmed

The Rhox gene cluster suppresses germline LINE1 transposition.

TNR CDH18

1.22e-046100234083437
Pubmed

PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis.

MTOR GLI1

1.70e-047100235858546
Pubmed

Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis.

MTOR GLI1

1.70e-047100230154246
Pubmed

DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.

LIG4 BRCA2

1.70e-047100221974800
Pubmed

Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.

LIG4 BRCA2

1.70e-047100216485136
Pubmed

MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.

DDT DDTL

1.70e-047100228539339
Pubmed

Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.

THRB MTOR

1.70e-047100226453307
Pubmed

Expression of hedgehog signalling components in adult mouse testis.

GLI1 PTCH2

2.27e-048100216958114
Pubmed

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.

GLI1 PTCH2

2.27e-048100210027293
Pubmed

Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient.

GLI1 PTCH2

2.27e-048100227498049
Pubmed

A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.

GLI1 PTCH2

2.27e-048100222869526
Pubmed

Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.

GLI1 PTCH2

2.27e-048100210529434
Pubmed

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.

ADNP RGL1 BRCA2

2.44e-0442100329348145
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

UBTD2 MYLK CENPC SPTBN2 TRIM43 RNF17 SH3D21 TASOR2 TRIM43B LIG4 SYNE2 GNA12 ERICH6

2.52e-0414421001335575683
Pubmed

Patched2 modulates tumorigenesis in patched1 heterozygous mice.

GLI1 PTCH2

2.91e-049100216849540
Pubmed

A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc).

GLI1 PTCH2

2.91e-049100211784021
Pubmed

The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.

GLI1 PTCH2

2.91e-049100217397822
Pubmed

Does adult fracture repair recapitulate embryonic skeletal formation?

BMP6 GLI1

2.91e-049100210495271
Pubmed

Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study.

BRCA2 MUTYH

2.91e-049100219902366
Pubmed

Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions.

LIG4 BRCA2

2.91e-049100218579371
Pubmed

The sonic hedgehog-patched-gli pathway in human development and disease.

GLI1 PTCH2

2.91e-049100211001584
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

NECAB2 RYR1 ZXDB LIG4 BMP6 THRB FGD4 DAAM1 ASIC4 ZNF654

3.10e-049151001032393512
Pubmed

The Shh signalling pathway in early tooth development.

GLI1 PTCH2

3.63e-0410100210512189
Pubmed

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.

GLI1 PTCH2

3.63e-0410100228344083
Pubmed

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

MTOR EEF2K

3.63e-0410100215809305
Pubmed

mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.

MTOR PAPPA

3.63e-0410100227618784
Pubmed

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.

MTOR GNA12

3.63e-0410100222609986
Pubmed

Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.

GLI1 PTCH2

3.63e-0410100211311154
Pubmed

Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.

GLI1 PTCH2

4.43e-041110029671585
Pubmed

mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition.

MTOR IMPG2

4.43e-0411100233052068
Pubmed

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

GLI1 PTCH2

4.43e-0411100210465785
Pubmed

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.

GLI1 PTCH2

4.43e-0411100217442700
Pubmed

Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.

GLI1 PTCH2

4.43e-0411100215668330
Pubmed

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.

CENPC SYNE2

4.43e-0411100222826121
Pubmed

Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina.

GLI1 PTCH2

4.43e-0411100216236765
Pubmed

Integral and associated lysosomal membrane proteins.

NAPG VPS16 MTOR CLN3

4.92e-04126100417897319
Pubmed

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

GLI1 PTCH2

5.30e-0412100211389830
Pubmed

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.

GLI1 PTCH2

5.30e-0412100236459481
Pubmed

Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.

GLI1 PTCH2

5.30e-0412100219445942
Pubmed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

GLI1 PTCH2

5.30e-0412100224990743
Pubmed

Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.

GLI1 PTCH2

5.30e-0412100210981962
Pubmed

Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.

GLI1 PTCH2

5.30e-0412100218417110
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

THRB PIK3C2G

5.30e-0412100228893949
Pubmed

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

ZXDC NECAB2 SCG5 THRB

6.03e-04133100415604093
Pubmed

Expression patterns of Hedgehog signalling pathway members during mouse palate development.

GLI1 PTCH2

6.25e-0413100216168717
Pubmed

IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.

BBS9 GLI1

6.25e-0413100225446516
Pubmed

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development.

GLI1 PTCH2

6.25e-0413100225448692
Pubmed

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.

GLI1 PTCH2

6.25e-0413100232332736
Pubmed

Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning.

BCAS3 AEBP1

6.25e-0413100229618843
Pubmed

Gli2 influences proliferation in the developing lung through regulation of cyclin expression.

GLI1 PTCH2

6.25e-0413100219574535
Pubmed

mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

VPS16 MTOR

6.25e-0413100225533187
Pubmed

Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.

GLI1 PTCH2

6.25e-0413100218625210
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN2 SPTBN5

6.25e-0413100218796539
Pubmed

cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.

MTOR EEF2K

6.25e-0413100218337751
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

VPS13C NAPG CUBN HNMT DDT RYR1 MELTF TREH KIFC3 ALK

6.98e-0410161001019056867
Pubmed

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

ZXDC UBTD2 CREB3L1 GSE1 CLK2 GRAP2 KIFC3

7.25e-04514100729892012
Pubmed

Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.

LIG4 BRCA2

7.28e-0414100217018785
Pubmed

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.

GLI1 PTCH2

7.28e-0414100216914743
Pubmed

Limb specific Acvr1-knockout during embryogenesis in mice exhibits great toe malformation as seen in Fibrodysplasia Ossificans Progressiva (FOP).

BMP6 GLI1

7.28e-0414100230854720
Pubmed

A genome-wide association study of optic disc parameters.

BCAS3 CDC7

7.28e-0414100220548946
Pubmed

Sonic hedgehog regulates branching morphogenesis in the mammalian lung.

GLI1 PTCH2

7.28e-041410029768363
Cytoband2q11.1

TRIM43 TRIM43B

1.71e-032810022q11.1
Cytoband17q24.2

ABCA9 FAM20A

1.96e-0330100217q24.2
Cytoband20q13.13

ADNP PTGIS

2.23e-0332100220q13.13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZXDC ZNF234 TRPS1 ZUP1 ZXDB GTF3A ZNF394 GLI1 ZNF639 ZNF239

1.32e-04718611028
GeneFamilyEF-hand domain containing|Spectrins

SPTBN2 SPTBN5

2.33e-0476121113
CoexpressionGSE3982_MAST_CELL_VS_NKCELL_DN

GPM6B SPTBN5 ZNF394 PIK3C2G ATRNL1 CHST4 SYNE2 MUTYH CDH18

7.33e-081991009M5452
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

CSMD3 RYR1 GRAP2 TNR ALK CDH18

2.45e-061711006b2e753e811a7639956994609f73efcdb62d04f82
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GPM6B MYLK CHD9 EEF2K KIFC3 FAM20A

2.80e-06175100669ed3c7c45df6bef70f5f2ff003531160bf3b32b
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Deep_layer_pyramidal_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

DPY19L2 SPTBN5 PIK3C2G PTCH2

2.91e-06441004405ac4aeee539322cfe661c7531248f81271be8d
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Slc24a2_(Deep_layer_pyramidal_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

DPY19L2 SPTBN5 PIK3C2G PTCH2

2.91e-06441004a2c99e8ca635590a1f167b68bc390e2aa01e26be
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 SPTBN2 CREB3L1 PIK3C2G PAPPA FAM20A

3.19e-061791006d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 SPTBN2 THRB PIK3C2G PAPPA FAM20A

3.62e-061831006b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTGIS ABCA9 AEBP1 GLI1 CHST4 PAPPA

4.10e-0618710064e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTGIS ABCA9 AEBP1 GLI1 CHST4 PAPPA

4.10e-061871006d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTGIS ABCA9 AEBP1 GLI1 CHST4 PAPPA

4.10e-061871006827eae63fabf6892a82ce7779b5f395958d3d628
ToppCelldroplet-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK PTGIS CREB3L1 AEBP1 FAM20A

4.10e-06187100651f1c6bac3abae1d20aa8ac46642bcdbc02cb0a2
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYLK RGS22 RRAD AEBP1 GLI1 ATRNL1

4.23e-0618810063177b2c1723268d330d3e9f24f9e24492ace6286
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

SCG5 ABCA9 AEBP1 GLI1 ATRNL1 PAPPA

4.23e-0618810068231e635706a296db6b6da1029a33bbc1b52478e
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYLK RRAD THRB AEBP1 GLI1 ATRNL1

4.23e-061881006293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PITPNM2 MYLK RRAD BMP6 ATRNL1 KLHL4

4.23e-061881006f54b063025d80de631382bf5326bc40aab7f7d00
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B MYLK PTGIS RGL1 AEBP1 ATRNL1

4.36e-061891006c734e5693808a0333139e87bd5be2597a9252afe
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGS22 RRAD AEBP1 GLI1 ATRNL1 PAPPA

4.36e-06189100645e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B MYLK PTGIS ABCA9 RGL1 ATRNL1

4.49e-0619010062e592323085ba9c019d678ac2a784462ab470ed9
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PITPNM2 MYLK RRAD BMP6 ATRNL1 KLHL4

4.49e-061901006938d1f66094b1c94606e0d40213a39e5112f3322
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B MYLK PTGIS ABCA9 RGL1 ATRNL1

4.49e-061901006445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B SPTBN2 THRB PIK3C2G PAPPA FAM20A

4.49e-061901006b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B MYLK TRPS1 PTGIS RGL1 ATRNL1

4.63e-061911006c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B MYLK TRPS1 PTGIS RGL1 ATRNL1

4.63e-061911006cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B VPS13C CHD9 PTGIS ABCA9 AEBP1

4.77e-06192100611088878043a6ff95ba1970361256a82e434b80a
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CSMD3 PTGIS ABCA9 CREB3L1 PAPPA KLHL4

4.92e-061931006cd45118ced91b10baed3b1068d4673ec99824b86
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

TRPS1 CHD9 PTGIS ABCA9 PAPPA DAAM1

5.22e-0619510066a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

MYLK PTGIS ABCA9 AEBP1 PAPPA PHLDB2

5.53e-061971006fb847f2277609c31fffcdf49517243ce0684facf
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK RRAD PTGIS ABCA9 AEBP1

5.53e-061971006cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCelldistal-2-mesenchymal-Airway_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPC1 GPM6B MYLK RRAD AEBP1 PAPPA

5.86e-061991006af226a6c50747dad9ca696463e715913b3ac17c0
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYLK PTGIS ABCA9 AEBP1 PAPPA PHLDB2

6.03e-062001006389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

GPC1 PTGIS AEBP1 PAPPA PHLDB2 KLHL4

6.03e-062001006c082bc21ec7c5323439d108ea8aea510e1113c3f
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYLK PTGIS ABCA9 AEBP1 PAPPA PHLDB2

6.03e-062001006cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGEF38 RAD9B CUBN BRCA2 DENND2C

1.50e-051381005611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CUBN CSMD3 ATRNL1 TNR CDH18

1.56e-051391005a1945b07f177cde40e7eea03a19236ce76165857
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNF17 SH3D21 CDC7 BRCA2 CHST4

2.04e-051471005c8e5bdc3538089acd35a4b41390afaec0ac6d1aa
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZXDC SPTBN5 SMG7 GSE1 TNR

2.11e-05148100510dcbdb47cac908648d9d652c8095b536db19b8a
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CSMD3 RYR1 ATRNL1 ALK CDH18

2.25e-0515010050205318a870e091add66ee4305747dda9f51510d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 SPTBN2 PIK3C2G PAPPA FAM20A

2.71e-051561005a4b0e89255ea5d60198cb2b3e739981f9c9cf5c5
ToppCellfacs-Lung-EPCAM-3m-Endothelial-endothelial_cell_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA14 BMP6 CLK2 TNR CDH18

2.71e-051561005bb64bf520cb74897a01c64924a85a1550df2b801
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD9B ITGAE MELTF CLN3 ZNF239

3.16e-0516110059703b7e67d9fadb6129cad166bd01be915042e44
ToppCellfacs-Heart-LV-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B SCG5 PTGIS TEX36 AEBP1

3.65e-051661005c02c2a68d61dbd7ed086d9b02cfcb1778b8a8656
ToppCellfacs-Heart-LV-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B SCG5 PTGIS TEX36 AEBP1

3.65e-05166100520c24a9d2eb67a20e5154d25656da14186034f02
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGIS CREB3L1 AEBP1 CHST4 SYNE2

3.76e-0516710057abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGIS CREB3L1 AEBP1 CHST4 SYNE2

3.76e-051671005d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LCA5 MYLK BMP6 DENND2C KIFC3

3.87e-0516810052d056cfbb470a088a0682576753535fb4528d48f
ToppCellAdult-Mesenchymal-chondrocyte-D175|Adult / Lineage, Cell type, age group and donor

PTGIS PIK3C2G PAPPA MUTYH KLHL4

3.87e-05168100514071b961c9bdb54a8259b12a88237b802cbde36
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LCA5 MYLK BMP6 DENND2C KIFC3

3.87e-0516810052f69e248c6fab1421c0081e01e1920e6ffcde344
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPY19L1 TRPS1 SPTBN5 BMP6 PIK3C2G

3.98e-051691005716e9d4c5fb99c56b76afaa5ed90bfa859fde802
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUBN RNF17 CSMD3 AEBP1 PIK3C2G

3.98e-05169100512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B HNMT PTGIS EEF2K ZNF239

4.32e-051721005574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

GPC1 CA14 CUBN BRCA2 ZNF239

4.32e-051721005e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCelldroplet-Liver-Hepatocytes-21m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B HNMT PTGIS EEF2K ZNF239

4.32e-0517210051627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NECAB2 CSMD3 CREB3L1 AEBP1 ASIC4

4.32e-0517210057e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCelldroplet-Lung-nan-21m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RRAD ITGAE RNF17 RYR1 CDC7

4.45e-0517310052eb6e9fc3a3654f6f86fbd112e80a18814afd103
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGIS AEBP1 CHST4 SYNE2 PAPPA

4.45e-05173100530d67738633493d47f06ae452424382f069b6c0a
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUBN RNF17 CSMD3 AEBP1 PIK3C2G

4.45e-05173100566f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CUBN RNF17 CSMD3 AEBP1 PIK3C2G

4.45e-051731005649b08a409095592cccf31883be69c754411280d
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTGIS AEBP1 CHST4 SYNE2 PAPPA

4.57e-051741005a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGEF28 MYLK THRB ATRNL1 SYNE2

5.09e-051781005544379f5a6145429762258d426b876bb36c112f5
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD9B RRAD PTGIS ZXDB TRIM43B

5.23e-051791005f99500c4a590e5152ded5862690f7fa614d64a80
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD9B RRAD PTGIS ZXDB TRIM43B

5.23e-0517910057d61466181ab73088de3ec8a129d7cfa8cac7ecc
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD9B RRAD PTGIS ZXDB TRIM43B

5.23e-0517910056c98ce32cb55cf9cee557449e41b23bdb22f5efd
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet-plt_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYLK BMP6 THRB DENND2C GRAP2

5.37e-0518010051be264962fd4ed0bb59f9b8a6956c4239ca32e05
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet-plt_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYLK BMP6 THRB DENND2C GRAP2

5.37e-0518010055568063c2518fadb638e665635061ec10d00fb6a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 ARHGEF38 PIK3C2G FGD4 PAPPA

5.51e-051811005aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPS1 CREB3L1 PIK3C2G PAPPA FAM20A

6.11e-051851005a0a629e5d2b65f670ea907bd3f5e3caf17687d8f
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPS1 HNMT RYR1 RGL1 FAM20A

6.11e-0518510058207f9eff113eed429e961748c6b17d672a13b33
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYLK PTGIS TADA1 PDP1 PHLDB2

6.11e-0518510055a0340c25196453f19e424d346efbf66d2c53ac3
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 TRPS1 PIK3C2G PAPPA FAM20A

6.27e-051861005aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYLK BMP6 DENND2C GRAP2 KIFC3

6.27e-051861005107bc473f5e57238390f8e0ab9f7263a8f93948c
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

SCG5 ABCA9 GLI1 PAPPA GNA12

6.27e-0518610051bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYLK BMP6 DENND2C GRAP2 KIFC3

6.27e-05186100513a9ddcf93b0c4319ab9d484af5e2056e9754caa
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF28 DPY19L2 SPTBN2 THRB DAAM1

6.27e-051861005a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

SCG5 ABCA9 GLI1 PAPPA GNA12

6.27e-05186100559db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LCA5 PDP1 ATRNL1 DPY19L2P1 CDH18

6.43e-051871005f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 SPTBN2 PIK3C2G PAPPA FAM20A

6.43e-0518710052d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK TRIM43 PTGIS AEBP1

6.43e-051871005976b74d081b7fba8620768613cc26f9262cd7b16
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 THRB PIK3C2G PAPPA FAM20A

6.43e-051871005e3095455d2f255854f339f6b05fa87852af0700f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 SPTBN2 PIK3C2G PAPPA FAM20A

6.59e-05188100558ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF28 SPTBN2 THRB FGD4 DAAM1

6.59e-051881005e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK PTGIS ABCA9 AEBP1

6.76e-0518910051821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCellLV-14._Fibroblast_III|World / Chamber and Cluster_Paper

TRPS1 ABCA9 MELTF GNA12 PHLDB2

6.76e-0518910053922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK PTGIS ABCA9 AEBP1

6.76e-0518910051e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B SPTBN2 PIK3C2G PAPPA FAM20A

6.76e-051891005bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK PTGIS AEBP1 FAM20A

6.76e-051891005324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCellHealthy-Platelet|Healthy / disease group, cell group and cell class

MYLK BMP6 DENND2C GRAP2 KIFC3

6.76e-0518910055863e132536594e49bffbb637454cc43dfdbaa20
ToppCelldroplet-Pancreas-PANCREAS-30m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6B MYLK PTGIS ABCA9 AEBP1

6.76e-0518910051dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPY19L2 SPTBN2 PIK3C2G PAPPA FAM20A

6.76e-051891005532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LCA5 PDP1 ATRNL1 DPY19L2P1 CDH18

6.76e-051891005c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D175|Adult / Lineage, Cell type, age group and donor

PTGIS ABCA9 AEBP1 PAPPA PHLDB2

6.93e-0519010057dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LCA5 PDP1 ATRNL1 DPY19L2P1 CDH18

6.93e-051901005d594da827e3c16644952b9589cc12b947ce36279
ToppCellrenal_medulla_nuclei-Adult_normal_reference|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

PITPNM2 BMP6 MELTF THRB FGD4

6.93e-051901005f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCellmild_COVID-19_(asymptomatic)-Platelet|World / disease group, cell group and cell class (v2)

MYLK BMP6 DENND2C GRAP2 KIFC3

6.93e-0519010057aaf82f0c235363afb95cf1fa51c2a5b070b1af8
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PTGIS ABCA9 CREB3L1 PAPPA KLHL4

6.93e-0519010054f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPM6B MYLK PTGIS AEBP1 FAM20A

7.11e-051911005094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B SPTBN2 PIK3C2G PAPPA FAM20A

7.11e-0519110057235a4d1601c88a2c8af571a2c04ab56d32f1b9a
ToppCellfacs-Lung-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GPM6B MYLK PTGIS AEBP1 FAM20A

7.11e-051911005ba02cbdfda6a94374a6472eb88499059979af472
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPM6B MYLK PTGIS AEBP1 ATRNL1

7.11e-051911005806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTGIS ABCA9 AEBP1 ATRNL1 KLHL4

7.11e-051911005107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTGIS ABCA9 AEBP1 ATRNL1 KLHL4

7.11e-051911005bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGS22 RRAD AEBP1 GLI1 ATRNL1

7.11e-051911005b133ee1c0e58d00ddd2e4e05b01fd04947524c18
DiseaseSarcomatoid Renal Cell Carcinoma

CSMD3 RYR1 MTOR SYNE2 ALK

6.65e-05128975C1266043
DiseaseChromophobe Renal Cell Carcinoma

CSMD3 RYR1 MTOR SYNE2 ALK

6.65e-05128975C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

CSMD3 RYR1 MTOR SYNE2 ALK

6.65e-05128975C1266044
DiseasePapillary Renal Cell Carcinoma

CSMD3 RYR1 MTOR SYNE2 ALK

6.65e-05128975C1306837
DiseaseRenal Cell Carcinoma

CSMD3 RYR1 MTOR SYNE2 ALK

6.65e-05128975C0007134
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

CSMD3 RYR1 MTOR SYNE2 ALK

1.32e-04148975C0279702
DiseaseMEDULLOBLASTOMA

BRCA2 PTCH2

1.59e-046972155255
DiseaseAdult only

BRCA2 MUTYH

1.59e-046972C3842001
DiseaseMedulloblastoma

BRCA2 PTCH2

1.59e-046972cv:C0025149
DiseaseGlioma

BRCA2 PTCH2

3.79e-049972cv:C0017638
DiseaseChildhood Medulloblastoma

SCG5 BRCA2 PTCH2

3.86e-0443973C0278510
DiseaseMelanotic medulloblastoma

SCG5 BRCA2 PTCH2

3.86e-0443973C1275668
DiseaseMedullomyoblastoma

SCG5 BRCA2 PTCH2

3.86e-0443973C0205833
DiseaseDesmoplastic Medulloblastoma

SCG5 BRCA2 PTCH2

3.86e-0443973C0751291
DiseaseAdult Medulloblastoma

SCG5 BRCA2 PTCH2

3.86e-0443973C0278876
Diseasemedulloblastoma (is_implicated_in)

BRCA2 PTCH2

4.73e-0410972DOID:0050902 (is_implicated_in)
Diseasebrain infarction (implicated_via_orthology)

ADNP HNMT

5.77e-0411972DOID:3454 (implicated_via_orthology)
DiseaseMedulloblastoma

SCG5 BRCA2 PTCH2

6.03e-0450973C0025149
Diseaseprostate cancer (is_implicated_in)

LIG4 THRB BRCA2 MTOR

6.12e-04117974DOID:10283 (is_implicated_in)
Diseaseosteoarthritis

PITPNM2 MYLK CSMD3 BMP6 ATRNL1

8.47e-04222975MONDO_0005178
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

TRPS1 THRB IFTAP CLPTM1 GNA12

2.14e-03274975EFO_0004530, EFO_0004612
Diseaseactivities of daily living score measurement

TRPS1 HNMT

2.16e-0321972EFO_0008451
DiseaseSelf-injurious behavior

SPTBN5 AEBP1 DAAM1

2.19e-0378973HP_0100716
DiseaseColorectal Carcinoma

SCG5 SPTBN2 CUBN CSMD3 ABCA9 BMP6 GSE1 MUTYH

2.22e-03702978C0009402
DiseaseFEV/FEC ratio

ARHGEF28 BCAS3 VPS13C TRPS1 ARHGEF38 NAPG SH3D21 SPTBN5 SYNE2 GNA12 PHLDB2

2.34e-0312289711EFO_0004713
DiseaseMalignant neoplasm of breast

GPC1 ARHGEF38 RRAD CUBN RGL1 BRCA2 MTOR GLI1 SYNE2 ALK

2.81e-0310749710C0006142
DiseaseHDL cholesterol change measurement

SYNE2 MED27

2.82e-0324972EFO_0007805
DiseaseGlioma

MYLK BRCA2 ALK

2.99e-0387973C0017638
Diseaseepiandrosterone sulfate measurement

ZNF394 ALK

3.05e-0325972EFO_0021120
Diseasebreast cancer (implicated_via_orthology)

THRB BRCA2

3.05e-0325972DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
SHFRNVHSEDFENRI

ADNP

91

Q9H2P0
HFAIISREQTHFSED

ERICH6

356

Q7L0X2
NESDFLNNAHFPEHL

CREB3L1

26

Q96BA8
TSNSHILRLEFQADH

CSMD3

801

Q7Z407
QNEVVATDDLDFRHH

AEBP1

551

Q8IUX7
VGFTLFQTHDNREHL

CLK2

376

P49760
SEHIQTDRSTFFEEH

ABCA9

1001

Q8IUA7
VHAFQARSDHELSLQ

ARHGEF38

721

Q9NXL2
EEFAHQFHESVLQST

GSE1

1021

Q14687
DTAEFSREFQLHQHL

SCG5

136

P05408
NDTSRNLEFHEIHST

BCAS3

71

Q9H6U6
AEDNRSHSAHFFEFL

DDTL

71

A6NHG4
LSDIFSDHNNHLTSR

RGL1

361

Q9NZL6
HSLNEAHQISLNEFT

PIK3C2G

76

O75747
QEHFNHPFDSLARAS

RAD9B

386

Q6WBX8
ETSAALHHNVQALFE

RRAD

231

P55042
NEHEDQHSLDLDRSF

ARHGEF28

331

Q8N1W1
TLFENDRHFSHLSSL

DPY19L2P1

121

Q6NXN4
SEDFHFEQRGTQHSL

MYLK

666

Q15746
ATQLRSFDDHFQHLL

GPC1

101

P35052
SFDDHFQHLLNDSER

GPC1

106

P35052
EQHFHSQVRESTICF

LMBR1

11

Q8WVP7
RNSEFLVHENNTHFL

ALOXE3

396

Q9BYJ1
SLANETHTLQFRHGF

ITGAE

951

P38570
VESFRRFLNHSTEHQ

HNMT

16

P50135
AEDNRSHSAHFFEFL

DDT

71

P30046
LQETIDAFHQRHETF

FGD4

516

Q96M96
LFENDRHFSHLSTLE

DPY19L1

41

Q2PZI1
FSESSERLFNGHHLQ

LCA5

511

Q86VQ0
ERLFNGHHLQDISFS

LCA5

516

Q86VQ0
FDSQEQLVHHINSEH

GLI1

246

P08151
NRFRHSALSDADIFH

ASIC4

121

Q96FT7
AFIAHFQDNLHSVNR

MED27

51

Q6P2C8
TREQVDFQHHQLAEA

PAPPA

371

Q13219
LADVLQTHNAAFQEH

PITPNM2

801

Q9BZ72
TLFENDRHFSHLSSL

DPY19L2

126

Q6NUT2
LEQHFSTNASDHALL

GPM6B

66

Q13491
SVFEDQNAATHLIRH

PDP1

471

Q9P0J1
NATRSEEQFHVINHA

KLHL4

151

Q9C0H6
VEQDSTELFTNHRHL

BBS9

856

Q3SYG4
RIHFHSDSQISDQGF

CUBN

681

O60494
REHENSTLDRHLDFF

DAAM1

321

Q9Y4D1
DNSSHILDHDLDRQF

CHD9

426

Q3L8U1
FLNTFTHLSQEDHVS

IFTAP

36

Q86VG3
QTIFSVFHNDAAELH

LIG4

201

P49917
VFHNDAAELHNVTTD

LIG4

206

P49917
ELHNFSLNSELHSDI

BRCA2

1456

P51587
DENIHTSHITQDEFQ

CENPC

441

Q03188
VFGERNFNIHSSISH

CDC7

286

O00311
QEHQHRDSDLFLLDT

BMP6

281

P22004
HTLEAFTQFAEGTNH

C1orf112

711

Q9NSG2
LFHHFTTAIDTENVR

GNA12

346

Q03113
FTFSLLQEDDRHHTA

ATRNL1

1116

Q5VV63
LQEDDRHHTAINFIA

ATRNL1

1121

Q5VV63
SFEFEDIQHFRNRNS

DENND2C

271

Q68D51
NIEGANTHLDFRFSH

CDH18

346

Q13634
QAFSHFTFERSGHQL

EEF2K

256

O00418
DFSISVRHEDDVQHF

GRAP2

91

O75791
SEHQINSEATFAELH

CA14

121

Q9ULX7
TTLFQHIAQHQFGDD

RYR1

3141

P21817
QLNHHIFELVSSSDA

MTOR

66

P42345
FHFEVTNHNIRLFED

TRIM43

291

Q96BQ3
TRDDIQFHHFSSEEA

SH3D21

381

A4FU49
AFVRHTTVFDNTNGH

MELTF

571

P08582
TEDQSFNDLAHDVIH

SYNE2

2041

Q8WXH0
LTQDNVHSHNDFLLA

TADA1

51

Q96BN2
LEFEHFRQFLETHSS

RGS22

861

Q8NE09
ESQAQDRVHSADVFH

PTGIS

191

Q16647
EFTNLNEHSSRSHAL

KIFC3

636

Q9BVG8
DFQRHNAEIAAFHLD

FAM20A

256

Q96MK3
HSQRALFDLHQRFSS

PTCH2

751

Q9Y6C5
NLFQLHHLRDFSNET

SMG7

301

Q92540
LDNFFRSHISTDAHS

MUTYH

526

Q9UIF7
EELQDSSSFHHQHLE

IMPG2

256

Q9BZV3
HFEDLEFQQLEHESR

PHLDB2

721

Q86SQ0
AHQIDEVLHFNEFSQ

SERPINB12

51

Q96P63
ENLAAAHEVHSFQQA

SPTBN5

3206

Q9NRC6
AHEVHSFQQAAAELQ

SPTBN5

3211

Q9NRC6
FQDHQDHALLLSTTD

ALK

511

Q9UM73
NTFHNIALETSDEHR

CLN3

391

Q13286
EHEHFTDFNATSALF

CLPTM1

111

O96005
GDHAFHTNARDALNV

CHST4

316

Q8NCG5
IDEALNTAHHSFEQL

RNF17

151

Q9BXT8
AADTQSLLEHFNTVH

TRPS1

701

Q9UHF7
FSHNRAHFREQELFS

ZXDB

411

P98169
HHSSLFETQRQLHEE

ZNF394

341

Q53GI3
VSALFSHNRAHFREQ

ZXDC

311

Q2QGD7
IFENLSQHIADTHFS

ZNF639

271

Q9UID6
ASREQHQFHRDVEDE

SPTBN2

1486

O15020
EAVAHENNRALFHAA

NAPG

61

Q99747
AAAHAFESNDHELAQ

UBTD2

76

Q8WUN7
SIFHLDHDDVNDQSV

THRB

66

P10828
NQDDNHQELGSFHIR

VPS16

621

Q9H269
SDHESQVTFTHRINF

TNR

106

Q92752
VLQTFTELSRDHNHS

TREH

66

O43280
NTLSLDIHENHSFAL

TPP2

916

P29144
FCQRQFEDSQHFIDH

ZNF654

791

Q8IZM8
FEDSQHFIDHLNRHS

ZNF654

796

Q8IZM8
AFHNDSFQLGELRLH

VPS13C

1961

Q709C8
SFTDVFNFDLHQQLH

ZNF234

156

Q14588
FHIETAHFEQNTLER

ZUP1

46

Q96AP4
FHFEVTNHNIRLFED

TRIM43B

291

A6NCK2
QHFCQAFHRENDTLI

TASOR2

2216

Q5VWN6
FNLQSHILSFHEESR

GTF3A

261

Q92664
FSQSSELLLHQRDHT

ZNF239

216

Q16600
NQFPFSVHDNRHSLE

TEX36

66

Q5VZQ5
DLFHTIDSDNTNHVD

NECAB2

101

Q7Z6G3