Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K9me/H3K9me2 demethylase activity	KDM3A HR	1.61e-04	5	81	2	GO:0140683
GeneOntologyMolecularFunction	prostaglandin E receptor activity	PTGER3 PTGER4	1.61e-04	5	81	2	GO:0004957
GeneOntologyMolecularFunction	glycerol channel activity	AQP10 AQP3	3.37e-04	7	81	2	GO:0015254
GeneOntologyMolecularFunction	urea transmembrane transporter activity	AQP10 AQP3	5.74e-04	9	81	2	GO:0015204
GeneOntologyMolecularFunction	glycerol transmembrane transporter activity	AQP10 AQP3	5.74e-04	9	81	2	GO:0015168
MousePheno	abnormal retina inner plexiform layer morphology	EPOR GDF11 CLCC1 HR	1.22e-05	33	61	4	MP:0003734
Domain	DUF4939	RTL8B RTL8A RTL8C	9.23e-06	10	81	3	PF16297
Domain	DUF4939	RTL8B RTL8A RTL8C	9.23e-06	10	81	3	IPR032549
Domain	LDOC1-rel	RTL8B RTL8A RTL8C	1.26e-05	11	81	3	IPR032567
Domain	HEAT	IPO5 STK36 RANBP6 PRKDC	5.52e-05	48	81	4	PF02985
Domain	Prostglndn_DP_rcpt	PTGER3 PTGER4	5.56e-05	3	81	2	IPR001244
Domain	VPS13_C	VPS13A VPS13B	1.11e-04	4	81	2	PF16909
Domain	SHR-BD	VPS13A VPS13B	1.11e-04	4	81	2	IPR009543
Domain	VPS13_C	VPS13A VPS13B	1.11e-04	4	81	2	IPR031645
Domain	SHR-BD	VPS13A VPS13B	1.11e-04	4	81	2	PF06650
Domain	HEAT	IPO5 STK36 RANBP6 PRKDC	1.17e-04	58	81	4	IPR000357
Domain	ATG_C	VPS13A VPS13B	1.84e-04	5	81	2	PF09333
Domain	Autophagy-rel_C	VPS13A VPS13B	1.84e-04	5	81	2	IPR015412
Domain	VPS13_N	VPS13A VPS13B	5.11e-04	8	81	2	IPR026854
Domain	Prostanoid_rcpt	PTGER3 PTGER4	5.11e-04	8	81	2	IPR008365
Domain	Chorein_N	VPS13A VPS13B	5.11e-04	8	81	2	PF12624
Domain	MIP_CS	AQP10 AQP3	8.17e-04	10	81	2	IPR022357
Domain	MIP	AQP10 AQP3	1.63e-03	14	81	2	PS00221
Domain	MIP	AQP10 AQP3	1.63e-03	14	81	2	PF00230
Domain	MIP	AQP10 AQP3	1.88e-03	15	81	2	IPR000425
Domain	-	AQP10 AQP3	1.88e-03	15	81	2	1.20.1080.10
Domain	PI3/4_kinase_CS	PI4KB PRKDC	1.88e-03	15	81	2	IPR018936
Domain	Aquaporin-like	AQP10 AQP3	1.88e-03	15	81	2	IPR023271
Domain	-	PI4KB PRKDC	2.14e-03	16	81	2	1.10.1070.11
Domain	PI3Kc	PI4KB PRKDC	2.14e-03	16	81	2	SM00146
Domain	RhoGAP	ARHGAP4 ARHGAP36 ARHGAP39	2.47e-03	62	81	3	SM00324
Domain	RhoGAP	ARHGAP4 ARHGAP36 ARHGAP39	2.59e-03	63	81	3	PF00620
Domain	RHOGAP	ARHGAP4 ARHGAP36 ARHGAP39	2.71e-03	64	81	3	PS50238
Domain	RhoGAP_dom	ARHGAP4 ARHGAP36 ARHGAP39	2.71e-03	64	81	3	IPR000198
Domain	-	ARHGAP4 ARHGAP36 ARHGAP39	2.71e-03	64	81	3	1.10.555.10
Domain	PI3/4_kinase_cat_dom	PI4KB PRKDC	2.72e-03	18	81	2	IPR000403
Domain	PI3_PI4_kinase	PI4KB PRKDC	2.72e-03	18	81	2	PF00454
Domain	PI3_4_KINASE_3	PI4KB PRKDC	2.72e-03	18	81	2	PS50290
Domain	PI3_4_KINASE_1	PI4KB PRKDC	2.72e-03	18	81	2	PS00915
Domain	PI3_4_KINASE_2	PI4KB PRKDC	2.72e-03	18	81	2	PS00916
Domain	HEAT_REPEAT	IPO5 RANBP6 PRKDC	3.49e-03	70	81	3	PS50077
Domain	Pentatricopeptide_repeat	DENND4A PRKDC	4.43e-03	23	81	2	IPR002885
Domain	JmjC	KDM3A HR	4.82e-03	24	81	2	PF02373
Domain	fn3	EPOR PRTG PTPRF IL23R	5.41e-03	162	81	4	PF00041
Domain	Rho_GTPase_activation_prot	ARHGAP4 ARHGAP36 ARHGAP39	6.62e-03	88	81	3	IPR008936
Pubmed	A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916).	RTL8B RTL8A RTL8C	1.31e-08	3	83	3	9403077
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	RTL8B RTL8A RTL8C	2.61e-07	6	83	3	35247097
Pubmed	A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.	RTL8B RTL8A RTL8C	2.13e-06	11	83	3	16093683
Pubmed	Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.	RTL8B RTL8A RTL8C	2.13e-06	11	83	3	15716091
Pubmed	Role of EP3 and EP4 prostaglandin receptors in reorganization of the cytoskeleton in mature human osteoclasts.	PTGER3 PTGER4	5.63e-06	2	83	2	15290741
Pubmed	Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice.	PRKDC HR	5.63e-06	2	83	2	21525235
Pubmed	Mechanism of prostaglandin (PG)E2-induced prolactin expression in human T cells: cooperation of two PGE2 receptor subtypes, E-prostanoid (EP) 3 and EP4, via calcium- and cyclic adenosine 5'-monophosphate-mediated signaling pathways.	PTGER3 PTGER4	5.63e-06	2	83	2	15528329
Pubmed	The Borrelia burgdorferi VlsE Lipoprotein Prevents Antibody Binding to an Arthritis-Related Surface Antigen.	PRKDC CLCC1	5.63e-06	2	83	2	32187539
Pubmed	Study of the Mechanism Underlying the Onset of Diabetic Xeroderma Focusing on an Aquaporin-3 in a Streptozotocin-Induced Diabetic Mouse Model.	AQP3 HR	5.63e-06	2	83	2	31382467
Pubmed	Significance of divergent expression of prostaglandin EP4 and EP3 receptors in human prostate cancer.	PTGER3 PTGER4	5.63e-06	2	83	2	23364535
Pubmed	Compartmentalization of aquaporins in the human intestine.	AQP10 AQP3	5.63e-06	2	83	2	18678926
Pubmed	Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4.	PTGER3 PTGER4	5.63e-06	2	83	2	20503412
Pubmed	Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation.	PTGER3 PTGER4	5.63e-06	2	83	2	21311040
Pubmed	Induction of adherent activity in mastocytoma P-815 cells by the cooperation of two prostaglandin E2 receptor subtypes, EP3 and EP4.	PTGER3 PTGER4	5.63e-06	2	83	2	12637575
Pubmed	The role of PGE(2) in human atherosclerotic plaque on platelet EP(3) and EP(4) receptor activation and platelet function in whole blood.	PTGER3 PTGER4	5.63e-06	2	83	2	21424266
Pubmed	The deleterious role of the prostaglandin E2 EP3 receptor in angiotensin II hypertension.	PTGER3 PTGER4	5.63e-06	2	83	2	32142358
Pubmed	Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice.	PTGER3 PTGER4	5.63e-06	2	83	2	27711210
Pubmed	Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors.	PTGER3 PTGER4	5.63e-06	2	83	2	22615395
Pubmed	Expression of CXCL4 and aquaporin 3 and 10 mRNAs in patients with otitis media with effusion.	AQP10 AQP3	1.69e-05	3	83	2	26810286
Pubmed	Cellular localization of mRNAs for prostaglandin E receptor subtypes in mouse gastrointestinal tract.	PTGER3 PTGER4	1.69e-05	3	83	2	9124591
Pubmed	Prostaglandin E2 receptor subtype EP2 gene expression in the mouse uterus coincides with differentiation of the luminal epithelium for implantation.	PTGER3 PTGER4	1.69e-05	3	83	2	9348184
Pubmed	Multiple roles of the PGE2 -EP receptor signal in vascular permeability.	PTGER3 PTGER4	1.69e-05	3	83	2	24923772
Pubmed	Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome.	PTGER3 PTGER4	1.69e-05	3	83	2	15976003
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	STK36 PTPRF LAMA3	1.69e-05	21	83	3	22959728
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RNF121 DENND4A PI4KB VPS13A TMEM131 STK11IP VPS13B CLCC1	2.80e-05	504	83	8	34432599
Pubmed	PGE2 -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors.	PTGER3 PTGER4	3.37e-05	4	83	2	30835912
Pubmed	Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes.	PTGER3 PTGER4	3.37e-05	4	83	2	9116135
Pubmed	Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.	PTGER4 IL23R	3.37e-05	4	83	2	17447842
Pubmed	Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.	PTGER3 PTGER4	3.37e-05	4	83	2	10749873
Pubmed	Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice.	PTGER3 PTGER4	3.37e-05	4	83	2	22442093
Pubmed	Analysis of the human VPS13 gene family.	VPS13A VPS13B	3.37e-05	4	83	2	15498460
Pubmed	The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis.	PTGER3 PTGER4	3.37e-05	4	83	2	12208866
Pubmed	Human adipose glycerol flux is regulated by a pH gate in AQP10.	AQP10 AQP3	3.37e-05	4	83	2	30420639
Pubmed	MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.	PRKDC PTGER4	3.37e-05	4	83	2	15265935
Pubmed	Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.	PTGER3 PTGER4	3.37e-05	4	83	2	12642666
Pubmed	Stimulation of renin release by prostaglandin E2 is mediated by EP2 and EP4 receptors in mouse kidneys.	PTGER3 PTGER4	3.37e-05	4	83	2	15113745
Pubmed	Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population.	PTGER3 PTGER4	3.37e-05	4	83	2	17877755
Pubmed	Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.	PTGER3 PTGER4	3.37e-05	4	83	2	11238561
Pubmed	Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors.	PTGER3 PTGER4	3.37e-05	4	83	2	17075575
Pubmed	Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.	PTGER3 PTGER4	3.37e-05	4	83	2	11602631
Pubmed	Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.	PTGER3 PTGER4	3.37e-05	4	83	2	9751056
Pubmed	Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics.	PTGER3 PTGER4	3.37e-05	4	83	2	20587336
Pubmed	Receptors and pathways mediating the effects of prostaglandin E2 on airway tone.	PTGER3 PTGER4	3.37e-05	4	83	2	12618422
Pubmed	Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells.	PTGER3 PTGER4	3.37e-05	4	83	2	12740571
Pubmed	Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibition.	PTGER3 PTGER4	3.37e-05	4	83	2	22573380
Pubmed	Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.	PTGER3 PTGER4	3.37e-05	4	83	2	22276108
Pubmed	Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.	PTGER3 PTGER4	3.37e-05	4	83	2	15806106
Pubmed	Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis.	PTGER3 PTGER4	3.37e-05	4	83	2	17003499
Pubmed	Prostaglandin E receptor EP1 controls impulsive behavior under stress.	PTGER3 PTGER4	3.37e-05	4	83	2	16247016
Pubmed	Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens.	EPOR SIRPG	3.37e-05	4	83	2	27456828
Pubmed	Aquaporins Mediate Silicon Transport in Humans.	AQP10 AQP3	3.37e-05	4	83	2	26313002
Pubmed	Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway.	EPOR HR	3.37e-05	4	83	2	21894148
Pubmed	Age-induced reprogramming of mast cell degranulation.	PTGER3 PTGER4	5.60e-05	5	83	2	16237060
Pubmed	PGE₂ promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells.	PTGER3 PTGER4	5.60e-05	5	83	2	25054560
Pubmed	Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.	PTGER3 PTGER4	5.60e-05	5	83	2	15372104
Pubmed	Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis.	PTGER3 PTGER4	5.60e-05	5	83	2	16446378
Pubmed	Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.	PTGER3 PTGER4	5.60e-05	5	83	2	21444662
Pubmed	Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation.	PTGER3 PTGER4	8.39e-05	6	83	2	24342806
Pubmed	Prostanoid receptors in anagen human hair follicles.	PTGER3 PTGER4	8.39e-05	6	83	2	18005048
Pubmed	PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice.	PTGER3 PTGER4	8.39e-05	6	83	2	22522619
Pubmed	Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.	PTGER3 PTGER4	8.39e-05	6	83	2	11533709
Pubmed	E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.	PTGER3 PTGER4	8.39e-05	6	83	2	15240726
Pubmed	Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice.	PTGER3 PTGER4	8.39e-05	6	83	2	16954344
Pubmed	Chromosomal localization of the human prostanoid receptor gene family.	PTGER3 PTGER4	8.39e-05	6	83	2	7759114
Pubmed	Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression.	PTGER3 PTGER4	8.39e-05	6	83	2	14632179
Pubmed	Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia.	EPOR GDF11	8.39e-05	6	83	2	31151988
Pubmed	Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor.	PTGER3 PTGER4	8.39e-05	6	83	2	15983244
Pubmed	Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.	PRKDC SIRPG	1.17e-04	7	83	2	23293079
Pubmed	COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.	PTGER3 PTGER4	1.17e-04	7	83	2	20110411
Pubmed	Differential stem- and progenitor-cell trafficking by prostaglandin E2.	PTGER3 PTGER4	1.17e-04	7	83	2	23485965
Pubmed	Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions.	PTGER3 PTGER4	1.17e-04	7	83	2	10593166
Pubmed	Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.	PTGER3 PTGER4	1.56e-04	8	83	2	15834430
Pubmed	The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.	PTGER3 PTGER4	1.56e-04	8	83	2	11927615
Pubmed	Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma.	PTGER3 PTGER4	1.56e-04	8	83	2	17496729
Pubmed	Genetically determined murine models of immunodeficiency.	PRKDC HR	1.56e-04	8	83	2	3297105
Pubmed	Prostanoid receptors: structures, properties, and functions.	PTGER3 PTGER4	1.56e-04	8	83	2	10508233
Pubmed	Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis.	PTGER3 PTGER4	1.56e-04	8	83	2	20566843
Pubmed	Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta.	PTGER3 PTGER4	1.56e-04	8	83	2	19966781
Pubmed	Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3.	PTGER3 PTGER4	1.56e-04	8	83	2	7910583
Pubmed	Adam10 mediates the choice between principal cells and intercalated cells in the kidney.	SLC26A4 AQP3	2.00e-04	9	83	2	24904084
Pubmed	Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression.	PTGER3 PTGER4	2.00e-04	9	83	2	21460251
Pubmed	Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.	PTGER3 PTGER4	2.00e-04	9	83	2	11782353
Pubmed	Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.	PKD2 AQP3	2.00e-04	9	83	2	18172001
Pubmed	Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.	PTGER3 PTGER4	2.00e-04	9	83	2	31688905
Pubmed	Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia.	AQP10 AQP3	2.50e-04	10	83	2	10318966
Pubmed	Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.	PRKDC SIRPG	2.50e-04	10	83	2	28783664
Pubmed	Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.	PRKDC SIRPG	2.50e-04	10	83	2	17982459
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	STK36 ABCA2 HIVEP2 PTPRF CDK13 EIF2B3 CYB561D2 PRKDC STK11IP HR	3.00e-04	1105	83	10	35748872
Pubmed	Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues.	AQP10 AQP3	3.05e-04	11	83	2	7530250
Pubmed	Water permeability and characterization of aquaporin-11.	AQP10 AQP3	3.05e-04	11	83	2	21251984
Pubmed	Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line.	AQP10 AQP3	3.05e-04	11	83	2	16596446
Pubmed	Novel variants in human Aquaporin-4 reduce cellular water permeability.	AQP10 AQP3	3.05e-04	11	83	2	18511455
Pubmed	Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.	IPO5 PRKDC	3.05e-04	11	83	2	15758953
Pubmed	Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.	AQP10 AQP3	3.05e-04	11	83	2	1510932
Pubmed	Mercury-sensitive residues and pore site in AQP3 water channel.	AQP10 AQP3	3.05e-04	11	83	2	9369468
Pubmed	Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.	AQP10 AQP3	3.05e-04	11	83	2	1373524
Pubmed	Functional characterization and localization of AQP3 in the human colon.	AQP10 AQP3	3.05e-04	11	83	2	10510269
Pubmed	Aquaporin-1, nothing but a water channel.	AQP10 AQP3	3.05e-04	11	83	2	14701836
Pubmed	Mechanism of selectivity in aquaporins and aquaglyceroporins.	AQP10 AQP3	3.05e-04	11	83	2	18202181
Pubmed	Functional characterization of human aquaporin 9 as a facilitative glycerol carrier.	AQP10 AQP3	3.05e-04	11	83	2	18762715
Cytoband	Ensembl 112 genes in cytogenetic band chrXq26	RTL8B ARHGAP36 RTL8A RTL8C	2.72e-04	171	83	4	chrXq26
Cytoband	16q24	TAF1C CDK10	4.32e-04	17	83	2	16q24
GeneFamily	Prostaglandin (prostanoid) receptors	PTGER3 PTGER4	2.88e-04	9	52	2	207
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP4 ARHGAP36 ARHGAP39	4.00e-04	50	52	3	721
GeneFamily	Aquaporins	AQP10 AQP3	7.22e-04	14	52	2	305
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PRTG PTPRF IGSF11 VSIG10	1.18e-03	161	52	4	593
GeneFamily	Cyclin dependent kinases	CDK13 CDK10	2.52e-03	26	52	2	496
Drug	Heymann Nephritis Antigenic Complex	PTGER3 PTGER4	1.28e-05	2	82	2	ctd:D026541
Drug	AC1L1H0W	PTGER3 PTGER4	3.84e-05	3	82	2	CID000003927
Drug	Misoprostol	PTGER3 PTGER4	3.84e-05	3	82	2	DB00929
Drug	Citalopram hydrobromide [59729-32-7]; Down 200; 1uM; MCF7; HT_HG-U133A	EPOR MTF2 CDK13 PDK3 AQP3 GPR176	7.24e-05	194	82	6	3903_DN
Drug	PF-00875133-00 [351322-64-0]; Down 200; 10uM; MCF7; HT_HG-U133A	EPOR HIVEP2 MTF2 FOXN3 AQP3 CFAP410	7.45e-05	195	82	6	5967_DN
Drug	Tolmetin sodium salt dihydrate [64490-92-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	EPOR ABCA2 FOXN3 AQP3 VPS13B CFAP410	7.45e-05	195	82	6	4167_DN
Drug	Oxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; HL60; HG-U133A	DENND4A MTF2 ASAH1 VPS13A RANBP6 CLCC1	7.45e-05	195	82	6	1431_DN
Drug	estradiol, USP; Up 200; 0.1uM; HL60; HT_HG-U133A	ABCA2 VSIG10 PTGER4 GPR176 VPS13B CFAP410	7.45e-05	195	82	6	2668_UP
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	IPO5 DNAH3 PDK3 VPS13A AQP3 HR	7.45e-05	195	82	6	7504_UP
Drug	PGF2 alpha-isopropyl ester	PTGER3 PTGER4	7.65e-05	4	82	2	CID005283077
Drug	Dinoprostone	PTGER3 PTGER4	7.65e-05	4	82	2	DB00917
Drug	anhydrolevuglandin E2	PTGER3 PTGER4	7.65e-05	4	82	2	CID006443956
Drug	N-((4-(5,9-diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo(3,4-g)quinolin-7-yl)-3-methylbenzyl)sulfonyl)-2-(2-methoxyphenyl)acetamide	PTGER3 PTGER4	7.65e-05	4	82	2	ctd:C528911
Drug	Cefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A	CLCN2 TAF1C VPS13A PTGER3 RTN2 HR	7.67e-05	196	82	6	4718_DN
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A	EPOR ABCA2 CDK13 PI4KB CDK10 CFAP410	7.89e-05	197	82	6	3412_UP
Drug	Pheniramine maleate [132-20-7]; Down 200; 11.2uM; MCF7; HT_HG-U133A	DNAH3 CLCN2 CDK13 TAF1C FOXN3 CDK10	7.89e-05	197	82	6	1492_DN
Drug	Pralidoxime chloride [51-15-0]; Down 200; 23.2uM; MCF7; HT_HG-U133A	IPO5 EPOR PI4KB VPS13A CFAP410 HR	8.11e-05	198	82	6	5383_DN
Drug	Midecamycin [35457-80-8]; Down 200; 5uM; PC3; HG-U133A	EPOR KDM3A CDK13 PRKDC FOXN3 PTGER4	8.11e-05	198	82	6	1943_DN
Drug	Metampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; HL60; HG-U133A	IPO5 EPOR DENND4A ASAH1 VPS13A VPS13B	8.34e-05	199	82	6	1440_DN
Drug	Acetohexamide [968-81-0]; Down 200; 12.4uM; PC3; HT_HG-U133A	EPOR HIVEP2 PI4KB FOXN3 HSD17B4 VPS13B	8.57e-05	200	82	6	1829_DN
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; HL60; HG-U133A	IPO5 EPOR DENND4A TAF1C PKD2 CLCC1	8.57e-05	200	82	6	2027_DN
Drug	Acyclovir [59277-89-3]; Up 200; 17.8uM; HL60; HG-U133A	EPOR DENND4A MTF2 VPS13A CDK10 CLCC1	8.57e-05	200	82	6	2044_UP
Drug	Azaguanine-8 [134-58-7]; Up 200; 26.2uM; MCF7; HT_HG-U133A	HIVEP2 CDK13 SLC26A4 VPS13A RTN2 CFAP410	8.57e-05	200	82	6	7444_UP
Disease	Cohen syndrome (implicated_via_orthology)	VPS13A VPS13B	2.12e-05	3	79	2	DOID:0111590 (implicated_via_orthology)
Disease	sugar consumption measurement	PTPRF IGSF11 CDK10 VPS13B	3.09e-04	120	79	4	EFO_0010158
Disease	Ankylosing spondylitis	PTGER4 IL23R	3.83e-04	11	79	2	C0038013
Disease	amyotrophic lateral sclerosis	STK36 SCN7A LAMA3 CFAP410	6.32e-04	145	79	4	MONDO_0004976
Disease	1,3,7-trimethylurate measurement	PTPRF AFP	7.27e-04	15	79	2	EFO_0021172
Disease	ulcerative colitis (is_implicated_in)	PTGER4 IL23R	9.38e-04	17	79	2	DOID:8577 (is_implicated_in)
Disease	ankylosing spondylitis (is_implicated_in)	PTGER4 IL23R	1.18e-03	19	79	2	DOID:7147 (is_implicated_in)
Disease	susceptibility to Mycobacterium tuberculosis infection measurement	MUC22 PTGER3 IL23R	1.61e-03	86	79	3	EFO_0008407
Disease	JT interval, response to sulfonylurea	IGSF11 HSD17B4	1.73e-03	23	79	2	EFO_0007885, EFO_0007922
Disease	neuroblastoma, cutaneous melanoma	UGT1A7 AQP3	2.56e-03	28	79	2	EFO_0000389, EFO_0000621
Disease	malaria	PDK3 MUC22 IL23R	2.62e-03	102	79	3	EFO_0001068

Protein segments in the cluster

Peptide	Gene	Start	Entry
PAKRIWLPDIVLYNN	CHRNB4	106	P30926
PLLPLIWQKFFLLYL	EPG5	1306	Q9HCE0
FYLKGLPRLRVLWLA	CFAP410	81	O43822
LVWERPTKVRLPKLY	SERPINF2	326	P08697
WLYTHPLIKLLFLPR	CASTOR1	21	Q8WTX7
IVGRLPWVKLPIYIL	AQP10	91	Q96PS8
PWVKLPIYILVQLLS	AQP10	96	Q96PS8
TINLDLPPYKRWHEL	ASAH1	51	Q13510
VAIRLYLQPWPVDVK	ASB6	381	Q9NWX5
VKALPLPDRLKWYLL	ASB6	396	Q9NWX5
TNKVITLWYRPPELL	CDK13	871	Q14004
LLDVRQLITLYGIWP	IQCA1	541	Q86XH1
RVLLDPEAYWEVKPL	NWD1	481	Q149M9
PEYLKRLPLQWVDIA	MTF2	256	Q9Y483
PYLSPLVVWKELESL	DENND4A	1636	Q7Z401
LPIDRPNTLDKWFLI	ARHGAP36	86	Q6ZRI8
LKLWYRELEEPLIPH	ARHGAP39	966	Q9C0H5
ILIKFANSPRPDLWV	LAMA3	156	Q16787
VWLPKVSLLANPVLF	GPR176	306	Q14439
EAWLPTLLLLRDYKI	MSS51	366	Q4VC12
VIKPSGYLQPWAIIL	MUC22	1651	E2RYF6
WTKLPLNVPKLVLIY	MIR17HG	16	Q75NE6
LLETKILERAPFWVP	HR	146	O43593
LDPWVYLLLRKILLR	PTGER3	341	P43115
NPILDPWIYILLRKT	PTGER4	321	P35408
KVLPWFEQLLPLIVN	IPO5	856	O00410
IEKKVSSLPLLLPYW	IAH1	216	Q2TAA2
LEQYLTIIPEKLKPW	PEG3	91	Q9GZU2
TDILISWLPIPAKYR	PRTG	531	Q2VWP7
LMEVPLPWLNIKIVY	HFM1	321	A2PYH4
GNKPLIWYPLNLLER	EIF2B3	31	Q9NR50
IPRPTYLWEKLDNTL	IGSF11	171	Q5DX21
ERIVQWPAITYKPLL	KDM3A	106	Q9Y4C1
ESLPKILYDPLPIIW	DNAH3	4036	Q8TD57
TPKVVTLWYRAPELL	CDK10	196	Q15131
IPPWLLDIKYLSPLL	CEP89	356	Q96ST8
EALKPEYVAPLVLWL	HSD17B4	211	P51659
LVTPWDYRIPKIRIS	DIS3L	366	Q8TF46
PTKRLPVKDIYNWIL	FOXN3	131	O00409
LKAQLWVYLRPVPRP	GDF11	176	O95390
RRILLLIPKWLYEDI	IL23R	386	Q5VWK5
IWDLILKYKPGRTIL	ABCA2	1161	Q9BZC7
WDQPALLKRPQLELY	ITIH6	1176	Q6UXX5
DTYLVLDKWLLPRNP	EPOR	366	P19235
PIRYEWVRDLLPKLH	DHX40	686	Q8IX18
EFWYLLKLTIELPKP	CFAP47	2631	Q6ZTR5
LLYPKLLPRWPLAKL	CYB561D2	141	O14569
PTILLWAARYDKIIP	AFP	176	P02771
SWLLPPQERIIMYEL	PTPRF	531	P10586
RLFKLKPPVWYLRSL	MAP3K15	471	Q6ZN16
KPPVWYLRSLVQNLL	MAP3K15	476	Q6ZN16
PLISVKPLDNWLLIY	PIWIL1	486	Q96J94
ALQWVIPYIRKESPL	RTL8A	76	Q9BWD3
RLTGPALQWVIPYIK	RTL8B	71	Q17RB0
RLTGPALQWVIPYIK	RTL8C	71	A6ZKI3
VYKTVPILELSPPLW	RTN2	286	O75298
ELSPLWLLAELRKLY	STK11IP	271	Q8N1F8
PKDPALLYQWEKLLR	FER1L5	611	A0AVI2
YLVDERLPLVPMLKW	TAF1C	466	Q15572
PPSRRPKLYIVNLQW	SIRT7	286	Q9NRC8
EILYLKPPWTLLHLL	SWT1	611	Q5T5J6
VPLWIKPYKILVISA	PI4KB	591	Q9UBF8
LIAVLLGPIYVPWKQ	SIRPG	371	Q9P1W8
WLLKQPVPKQIERYS	PDK3	6	Q15120
YKEKILPWFEQLLPL	RANBP6	861	O60518
LWRLPAPVLVVLRYL	ARHGAP4	621	P98171
FQLVSLILKDPVRWP	STK36	206	Q9NRP7
EPWIKLPIYTLAQTL	AQP3	96	Q92482
KYYELLLVNPIWLVP	CLCC1	281	Q96S66
IIRIKKLPYLPELGW	CLCN2	556	P51788
KLRNLDLLIYPWPEL	RPP38-DT	91	Q8N326
IYIPTAILWIIPQKA	YIPF1	211	Q9Y548
HLWPPILLRNLLPYK	VPS13A	2106	Q96RL7
RNILIVLTKILPWYP	THOC2	1121	Q8NI27
VLTKILPWYPKVLNL	THOC2	1126	Q8NI27
KTLVPILEWLPKYRV	SLC26A4	66	O43511
LPRPNWELALYIIIS	TMEM131	1111	Q92545
PLVQTTPRLVYKWFL	RNF121	126	Q9H920
LPWVEKYRPVKLNEI	RFC2	36	P35250
VIPSWQFQPLKLIRY	PKD2	451	Q13563
LPPDVLRWVELAKLY	PRKDC	2916	P78527
LSIWKPYVRTLLIEL	VPS13B	2971	Q7Z7G8
PYVRTLLIELLPWAL	VPS13B	2976	Q7Z7G8
AYPPAKILWLRNLTQ	VSIG10	336	Q8N0Z9
PKWRPVLENTLLGIY	SCN7A	141	Q01118
LEKYPIWKAPQTLPL	HIVEP2	1401	P31629
WLLRTDFVLEYPKPV	UGT1A7	251	Q9HAW7
YKEEWPLLIVVPSSL	ZRANB3	76	Q5FWF4