Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	1.52e-20	431	116	27	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR10D4P OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	1.61e-14	884	116	29	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 PKD1L3 OR10D4P SORT1 OR8A1 OR4C3 OR4A15 TLR4 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 UNC5D OR4A4P OR4C5	7.34e-13	1353	116	33	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8K1 OR5M1 OR5D14 OR8K5 OR14J1 OR8A1	9.85e-05	127	116	6	GO:0005549
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 TLR9 PKD1L3 OR10D4P OR8A1 OR4C3 OR4A15 TLR4 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	4.30e-22	524	116	30	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	7.10e-21	432	116	27	GO:0050911
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 PKD1L3 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	1.02e-20	485	116	28	GO:0050907
GeneOntologyBiologicalProcess	sensory perception of smell	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	4.78e-20	465	116	27	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 PKD1L3 OR10D4P OR8A1 OR4C3 OR4A15 TLR4 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	1.07e-19	582	116	29	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 PKD1L3 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	2.51e-19	547	116	28	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 TLR9 PKD1L3 OR10D4P OR8A1 OR4C3 OR4A15 TLR4 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	3.59e-18	722	116	30	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 PKD1L3 OR10D4P OR8A1 OR4C3 OR4A15 TLR4 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	9.24e-13	1072	116	29	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR10D4P SORT1 OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 PADI2 OR4A4P OR4C5	2.09e-11	1395	116	31	GO:0007186
Domain	Olfact_rcpt	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	2.20e-16	393	115	23	IPR000725
Domain	G_PROTEIN_RECEP_F1_1	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	4.73e-13	685	115	25	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	5.74e-13	691	115	25	PS50262
Domain	GPCR_Rhodpsn	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	5.92e-13	692	115	25	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2	2.22e-12	670	115	24	IPR017452
Domain	7tm_1	OR2A14 OR8K1 GPR3 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4Q3 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 FSHR OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	2.77e-12	677	115	24	PF00001
Domain	NUT	NUTM2A NUTM2B	3.71e-04	5	115	2	IPR024310
Domain	NUT_N	NUTM2A NUTM2B	3.71e-04	5	115	2	IPR024309
Domain	NUT	NUTM2A NUTM2B	3.71e-04	5	115	2	PF12881
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	7.79e-18	417	91	25	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2	3.40e-15	389	91	22	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR2T2 OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR3A3 OR4B1 OR2V2 OR4C5	1.39e-13	636	91	25	M41834
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR4B1 OR2V2 OR4A4P OR4C5	3.21e-23	340	120	23	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR4B1 OR2V2 OR4A4P OR4C5	3.21e-23	340	120	23	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR4B1 OR2V2 OR4A4P OR4C5	3.92e-23	343	120	23	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR4A47 OR8K5 OR4C45 OR4Q3 OR2V1 OR14J1 OR10D4P OR8A1 OR4C3 OR4A15 OR4C46 OR2D3 OR4B1 OR2V2 OR4A4P OR4C5	4.78e-23	346	120	23	14611657
Pubmed	The human olfactory receptor gene family.	OR2A14 OR8K1 OR5M1 OR4S2 OR4C6 OR5D14 OR13C3 OR2T7 OR6Q1 OR4A47 OR8K5 OR4Q3 OR14J1 OR2T2 OR10D4P OR8A1 OR4C3 OR4A15 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P OR4C5	6.61e-20	541	120	24	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2A14 OR8K1 OR5M1 OR4S2 OR5D14 OR2T7 OR6Q1 OR4A47 OR2T2 OR8A1 OR4A15 OR2D3 OR3A3 OR4B1 OR2V2 OR4A4P	6.12e-17	219	120	16	12213199
Pubmed	The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells.	TLR9 TLR4	1.18e-05	2	120	2	18092352
Pubmed	TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo.	TLR9 TLR4	1.18e-05	2	120	2	28426135
Pubmed	Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivo.	XPO4 ARAP2	1.18e-05	2	120	2	11754636
Pubmed	Acquisition of adult-like TLR4 and TLR9 responses during the first year of life.	TLR9 TLR4	1.18e-05	2	120	2	20442853
Pubmed	Assessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma.	TLR9 TLR4	1.18e-05	2	120	2	32173390
Pubmed	Increased expression of Toll-like receptors 4 and 9 in human lung cancer.	TLR9 TLR4	1.18e-05	2	120	2	18763053
Pubmed	Alveolar bone loss in relation to toll-like receptor 4 and 9 genotypes and Porphyromonas gingivalis carriage.	TLR9 TLR4	1.18e-05	2	120	2	27492306
Pubmed	Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.	GPR3 SIK2	1.18e-05	2	120	2	34302056
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	1.18e-05	2	120	2	18826608
Pubmed	Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.	TLR4 SMPD1	1.18e-05	2	120	2	17381401
Pubmed	Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis.	TLR9 TLR4	1.18e-05	2	120	2	25400780
Pubmed	Toll-like receptor gene polymorphisms are associated with susceptibility to Graves' ophthalmopathy in Taiwan males.	TLR9 TLR4	1.18e-05	2	120	2	21050493
Pubmed	TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis.	TLR9 TLR4	1.18e-05	2	120	2	32753695
Pubmed	Polymorphisms and haplotypes of TLR-4/9 associated with bacterial infection, gingival inflammation/recession and oral cancer.	TLR9 TLR4	1.18e-05	2	120	2	36563560
Pubmed	TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis.	TLR9 TLR4	1.18e-05	2	120	2	33910419
Pubmed	Polymorphisms and expression of TLR4 and 9 in malaria in two ethnic groups of Assam, northeast India.	TLR9 TLR4	1.18e-05	2	120	2	22948021
Pubmed	Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis.	TLR9 TLR4	1.18e-05	2	120	2	34416273
Pubmed	Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.	DOCK2 SULT2B1	1.18e-05	2	120	2	30065028
Pubmed	Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.	TLR9 TLR4	1.18e-05	2	120	2	16779724
Pubmed	TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus.	TLR9 TLR4	1.18e-05	2	120	2	25844529
Pubmed	Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.	TLR9 TLR4	1.18e-05	2	120	2	19923461
Pubmed	Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.	TLR9 TLR4	1.18e-05	2	120	2	12356687
Pubmed	Immunohistochemical expression of TLR4 and TLR9 in various grades of oral epithelial dysplasia and squamous cell carcinoma, and their roles in tumor progression: a pilot study.	TLR9 TLR4	1.18e-05	2	120	2	23651260
Pubmed	Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children.	TLR9 TLR4	1.18e-05	2	120	2	32967147
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	1.18e-05	2	120	2	23555306
Pubmed	Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease.	TLR9 TLR4	1.18e-05	2	120	2	30057921
Pubmed	The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis.	TLR9 TLR4	1.18e-05	2	120	2	28618428
Pubmed	TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells.	TLR9 TLR4	1.18e-05	2	120	2	25499923
Pubmed	Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice.	TLR9 TLR4	1.18e-05	2	120	2	24719374
Pubmed	Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages.	TLR9 TLR4	1.18e-05	2	120	2	20843333
Pubmed	Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.	TLR9 TLR4	1.18e-05	2	120	2	33369094
Pubmed	TLR9 and MyD88 are crucial for the development of protective immunity to malaria.	TLR9 TLR4	1.18e-05	2	120	2	22516959
Pubmed	Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.	TLR9 TLR4	1.18e-05	2	120	2	12515817
Pubmed	Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.	TLR9 TLR4	1.18e-05	2	120	2	31365550
Pubmed	Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.	TLR9 TLR4	1.18e-05	2	120	2	22070100
Pubmed	The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor.	SORT1 SMPD1	1.18e-05	2	120	2	16787399
Pubmed	Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel method applied to the analysis of the Portuguese population.	TLR9 TLR4	1.18e-05	2	120	2	17482427
Pubmed	Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils.	TLR9 TLR4	1.18e-05	2	120	2	27993530
Pubmed	Association of polymorphisms in Toll-like receptors 4 and 9 with risk of pulmonary tuberculosis: a meta-analysis.	TLR9 TLR4	1.18e-05	2	120	2	25889916
Pubmed	Toll-like receptor 9 deficiency impacts sensory and motor behaviors.	TLR9 TLR4	1.18e-05	2	120	2	23624295
Pubmed	[Association of Toll-like receptor gene with Crohn's disease in Koreans].	TLR9 TLR4	1.18e-05	2	120	2	20026892
Pubmed	Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility.	TLR9 TLR4	1.18e-05	2	120	2	31278284
Pubmed	Critical role of TLR9 in acute graft-versus-host disease.	TLR9 TLR4	1.18e-05	2	120	2	18941203
Pubmed	Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents.	TLR9 TLR4	1.18e-05	2	120	2	23021866
Pubmed	The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo.	TLR9 TLR4	1.18e-05	2	120	2	18641311
Pubmed	Association of TLR4 and TLR9 gene polymorphisms with cervical HR-HPV infection status in Chinese Han population.	TLR9 TLR4	1.18e-05	2	120	2	36915050
Pubmed	Polymorphisms in Toll-like receptors genes changes the host's immune response and is associated with cervical cancer.	TLR9 TLR4	1.18e-05	2	120	2	35158151
Pubmed	TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.	TLR9 TLR4	1.18e-05	2	120	2	20810248
Pubmed	TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.	TLR9 TLR4	1.18e-05	2	120	2	34216140
Pubmed	Association between TLR4 and TLR9 gene polymorphisms with development of pulmonary tuberculosis in Zahedan, southeastern Iran.	TLR9 TLR4	1.18e-05	2	120	2	23766695
Pubmed	TLR4 and TLR9 are induced in oral lichen planus.	TLR9 TLR4	1.18e-05	2	120	2	22672741
Pubmed	Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women.	TLR9 TLR4	1.18e-05	2	120	2	37097031
Pubmed	TLR4 and TLR9 polymorphisms are not associated with either rheumatoid arthritis or systemic lupus erythematosus in Mexican patients.	TLR9 TLR4	1.18e-05	2	120	2	33939072
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	GPR3 NRDC OR2T7 OR2T2 NOL9 SPATA1 STRIP1 SORT1 TBX19 NDC1 SLC16A4 ZBTB18 PADI2 ZMYND12	1.35e-05	1031	120	14	16710414
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR2T7 OR2V1 OR2T2 OR2V2	1.97e-05	46	120	4	32126975
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	POLE UBR4 USP24 DNAH2 BTAF1 DNAJB14 SORT1 GLMN ATP2C1 NDC1 NUP210 PDS5A GCN1	2.36e-05	942	120	13	31073040
Pubmed	TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.	TLR9 TLR4	3.53e-05	3	120	2	17914947
Pubmed	Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.	TLR9 TLR4	3.53e-05	3	120	2	27505671
Pubmed	Expression of toll-like receptors on antigen-presenting cells in patients with falciparum malaria.	TLR9 TLR4	3.53e-05	3	120	2	17854755
Pubmed	Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist.	TLR9 TLR4	3.53e-05	3	120	2	21368092
Pubmed	[Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations].	TLR9 TLR4	3.53e-05	3	120	2	20646633
Pubmed	Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.	TLR9 TLR4	3.53e-05	3	120	2	16371473
Pubmed	Toll-like receptor signaling in anti-cancer immunity.	TLR9 TLR4	3.53e-05	3	120	2	12630564
Pubmed	Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients.	TLR9 TLR4	3.53e-05	3	120	2	23425749
Pubmed	Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.	TLR9 TLR4	3.53e-05	3	120	2	21547259
Pubmed	A pilot study on expression of toll like receptors (TLRs) in response to herpes simplex virus (HSV) infection in acute retinal pigment epithelial cells (ARPE) cells.	TLR9 TLR4	3.53e-05	3	120	2	25121361
Pubmed	Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.	TLR9 TLR4	3.53e-05	3	120	2	19933834
Pubmed	Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.	TLR9 TLR4	3.53e-05	3	120	2	17371986
Pubmed	Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.	TLR9 TLR4	3.53e-05	3	120	2	20804821
Pubmed	Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.	TLR9 TLR4	3.53e-05	3	120	2	18275280
Pubmed	TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.	TLR9 TLR4	3.53e-05	3	120	2	20526283
Pubmed	Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation.	TLR9 TLR4	3.53e-05	3	120	2	19539691
Pubmed	Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis.	TLR9 TLR4	3.53e-05	3	120	2	17875630
Pubmed	Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.	TLR9 TLR4	3.53e-05	3	120	2	22662111
Pubmed	Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients.	TLR9 TLR4	3.53e-05	3	120	2	28255201
Pubmed	Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium.	TLR9 TLR4	3.53e-05	3	120	2	28988039
Pubmed	Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.	TLR9 TLR4	3.53e-05	3	120	2	37718198
Pubmed	Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.	TLR9 TLR4	3.53e-05	3	120	2	29883450
Pubmed	Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice.	TLR9 TLR4	3.53e-05	3	120	2	15538945
Pubmed	TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.	TLR9 TLR4	3.53e-05	3	120	2	17599410
Pubmed	Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients.	TLR9 TLR4	3.53e-05	3	120	2	21457584
Pubmed	TLR9-IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction.	TLR9 TLR4	3.53e-05	3	120	2	33093516
Pubmed	Association of toll-like receptor gene polymorphisms and its interaction with HPV infection in determining the susceptibility of cervical cancer in Chinese Han population.	TLR9 TLR4	3.53e-05	3	120	2	28497211
Pubmed	Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns.	TLR9 TLR4	3.53e-05	3	120	2	16731773
Pubmed	Expressions of Toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women.	TLR9 TLR4	3.53e-05	3	120	2	21527067
Pubmed	Quantitative defects in invariant NKT cells and TLR responses in patients with hyper-IgE syndrome.	TLR9 TLR4	3.53e-05	3	120	2	25796310
Pubmed	Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.	TLR9 TLR4	3.53e-05	3	120	2	31270160
Pubmed	Genetic alterations within TLR genes in development of Toxoplasma gondii infection among Polish pregnant women.	TLR9 TLR4	3.53e-05	3	120	2	28500897
Pubmed	Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome.	TLR9 TLR4	3.53e-05	3	120	2	28246611
Pubmed	Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner.	TLR9 TLR4	3.53e-05	3	120	2	22677561
Pubmed	The genomic and clinical landscape of fetal akinesia.	IQSEC3 GCN1	3.53e-05	3	120	2	31680123
Pubmed	Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression.	TLR9 TLR4	3.53e-05	3	120	2	36926756
Pubmed	Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.	TLR9 TLR4	3.53e-05	3	120	2	23855294
Pubmed	Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members.	TLR9 TLR4	3.53e-05	3	120	2	28487240
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4S2 OR4C6 OR5D14 OR4A15 OR4C46 OR4A4P	1.00e-09	40	120	6	chr11q11
Cytoband	11q11	OR4S2 OR4C6 OR5D14 OR4A15	7.26e-06	47	120	4	11q11
Cytoband	Ensembl 112 genes in cytogenetic band chr11p11	OR4A47 OR4C45 OR4C3 OR4B1 OR4C5	5.39e-05	153	120	5	chr11p11
Cytoband	11p11.2	OR4A47 OR4C3 OR4B1 OR4C5	6.95e-05	83	120	4	11p11.2
Cytoband	11p11.12	OR4C45 OR4C46 OR4A4P	1.86e-04	42	120	3	11p11.12
Cytoband	1q44	TRIM58 OR2T7 OR2T2 ZBTB18	2.07e-04	110	120	4	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	TRIM58 OR2T7 OR2T2 ZBTB18	3.69e-04	128	120	4	chr1q44
Cytoband	1p13.3	STRIP1 SORT1 SLC16A4	8.05e-04	69	120	3	1p13.3
Cytoband	11q12.1	OR8K1 OR5M1 OR6Q1 OR8K5	8.73e-04	161	120	4	11q12.1
GeneFamily	Olfactory receptors, family 4	OR4S2 OR4C6 OR4A47 OR4C45 OR4Q3 OR4C3 OR4A15 OR4C46 OR4B1 OR4A4P OR4C5	1.89e-11	129	84	11	151
GeneFamily	Olfactory receptors, family 2	OR2A14 OR2T7 OR2V1 OR2T2 OR2D3 OR2V2	1.43e-05	113	84	6	149
GeneFamily	CD molecules\|Toll like receptors	TLR9 TLR4	9.37e-04	10	84	2	948
GeneFamily	Olfactory receptors, family 8	OR8K1 OR8K5 OR8A1	1.53e-03	49	84	3	155
Coexpression	GSE32034_UNTREATED_VS_ROSIGLIZATONE_TREATED_LY6C_LOW_MONOCYTE_UP	DHX16 CACUL1 SLC11A2 OR5M1 UBR4 OMD OR10D4P OR8A1 OR4C5	1.29e-07	193	110	9	M9056
Disease	mastitis (biomarker_via_orthology)	TLR9 TLR4	1.23e-05	2	104	2	DOID:10690 (biomarker_via_orthology)
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.22e-04	5	104	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.83e-04	6	104	2	C0334488
Disease	Crohn's disease of large bowel	NCF4 TLR9 TLR4	5.07e-04	44	104	3	C0156147
Disease	IIeocolitis	NCF4 TLR9 TLR4	5.07e-04	44	104	3	C0949272
Disease	Crohn's disease of the ileum	NCF4 TLR9 TLR4	5.07e-04	44	104	3	C0267380
Disease	Regional enteritis	NCF4 TLR9 TLR4	5.07e-04	44	104	3	C0678202
Disease	cutaneous leishmaniasis (is_marker_for)	TLR9 TLR4	5.44e-04	10	104	2	DOID:9111 (is_marker_for)
Disease	allergic conjunctivitis (is_marker_for)	TLR9 TLR4	5.44e-04	10	104	2	DOID:11204 (is_marker_for)
Disease	Crohn Disease	NCF4 TLR9 TLR4	7.39e-04	50	104	3	C0010346
Disease	Ischemic stroke, fibrinogen measurement	HDAC9 RAPGEF6 CHD9	9.77e-04	55	104	3	EFO_0004623, HP_0002140
Disease	Adenocarcinoma Of Esophagus	DOCK2 TLR4	1.09e-03	14	104	2	C0279628
Disease	allergic rhinitis (is_marker_for)	TLR9 TLR4	1.62e-03	17	104	2	DOID:4481 (is_marker_for)
Disease	dermatomyositis (is_marker_for)	TLR9 TLR4	1.62e-03	17	104	2	DOID:10223 (is_marker_for)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR9 TLR4	1.62e-03	17	104	2	DOID:8677 (biomarker_via_orthology)
Disease	sinusitis (is_marker_for)	TLR9 TLR4	1.81e-03	18	104	2	DOID:0050127 (is_marker_for)
Disease	blood metabolite measurement	TRIM58 SARDH	2.02e-03	19	104	2	EFO_0005664
Disease	Diuretic use measurement	OR4A15 KCNK3 SIK2 OR4A4P	3.06e-03	169	104	4	EFO_0009928
Disease	Colorectal Carcinoma	CACUL1 SLC11A2 POLE TLR9 SULT2B1 TLR4 DHRS2 NODAL	3.43e-03	702	104	8	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLRLDLMTPYLNTSN	PRMT9	756	Q6P2P2
AENLPAMYPSISDLI	CCDC7	981	Q96M83
LSPYPGLRLISLNMN	SMPD1	371	P17405
AQQAYSTLVPMPLLV	ARHGEF38	506	Q9NXL2
LFLYLSLLPMPLLSQ	ERVV-2	6	B6SEH9
EMIVNDLYVPSSPIL	ARAP2	251	Q8WZ64
LNIKLEMYPPLNQTL	CEP76	246	Q8TAP6
ELLVLPIYANLPSDM	DHX16	641	O60231
QALMLPLLSPVTFNS	CDC42EP3	116	Q9UKI2
LISLATLMNFPNPLN	ATP2C1	716	P98194
IYSLMPLLLEAQSTP	CACUL1	261	Q86Y37
LPQNLLYTVSERQPM	RBM27	416	Q9P2N5
LMPLPQTLSLYQDPL	OTUD4	651	Q01804
NPMATEKLLSLLPEY	PDS5A	986	Q29RF7
LLPYLALLTIPMRNQ	RAD17	561	O75943
DMTSTLNFLPLPLVQ	INTS9	31	Q9NV88
TVVNPMLNPLIYSLR	OR5D14	281	Q8NGL3
RLTLAPVYTSPQLDM	NUP210	751	Q8TEM1
DLSILSYLSQLQPPM	NOL9	521	Q5SY16
QSNMSYLLVLPSTLP	PCDH20	746	Q8N6Y1
VIPMLNPLIYSLRNE	OR8K5	281	Q8NH50
NPMLNPLIYSLRNAE	OR2A14	281	Q96R47
LVTPMLNPLIYSLRN	OR10D4P	276	Q8NGN7
SAFYTILTPMLNPLI	OR2T2	276	Q6IF00
ILTPMLNPLIYSLRN	OR2T2	281	Q6IF00
TLSKLPLQANVYPMT	MAN2A1	906	Q16706
LQYSIPMIIPRDLST	KCNK3	321	O14649
AINQLDIPPMLISYL	ASB12	291	Q8WXK4
LLQRQMTLVPPAYSA	KCNH2	1066	Q12809
DMKQVPALTPLYLLS	HLCS	376	P50747
SMLQAPPLTSLQLSL	DYNC2I2	421	Q96EX3
QNISVMENTLLPYLP	FSIP2	2611	Q5CZC0
LFLYLSLLPMPLLSQ	ERVV-1	6	B6SEH8
TKMLSQPYLLDPSIT	TSFM	281	P43897
PTLNPVIYSLRNDSM	OR14J1	281	Q9UGF5
ITPMLNPLIYTLKNA	OR4A15	306	Q8NGL6
ITPMLNPLIYTLRNS	OR4A47	276	Q6IF82
TLFTPMLNPLIYTVK	OR4C45	271	A6NMZ5
ITPMLNPLIYTLKNA	OR4C46	276	A6NHA9
SAFYTILTPMLNPLI	OR2T7	266	P0C7T2
ILTPMLNPLIYSLRN	OR2T7	271	P0C7T2
SIFYTVLTPMLNPLI	OR2V1	276	Q8NHB1
VLTPMLNPLIYSLRN	OR2V1	281	Q8NHB1
SIFYTVLTPMLNPLI	OR2V2	276	Q96R30
VLTPMLNPLIYSLRN	OR2V2	281	Q96R30
NPMLNPLIYSLRNTD	OR3A3	291	P47888
PMLNPLIYTLRNTDM	OR4Q3	281	Q8NH05
ITPMLNPLIYTLRNA	OR4S2	276	Q8NH73
YLVLLEMPFSPQLES	MUC3A	3086	Q02505
IPALNAYMKSLLSLP	NCF4	106	Q15080
LGLTAQPELYLLNTM	SLC11A2	546	P49281
IASMLPEQLYFLQSP	MSANTD3	111	Q96H12
SMYAETAIALLLPQL	GCN1	1806	Q92616
YPNIILTNRLQPSAM	POLE	631	Q07864
TPMLNPLIYSLRNKE	OR6Q1	286	Q8NGQ2
AVTPMLNPIIYSLRN	OR2D3	296	Q8NGH3
SLLEYMAQDIPLTPI	PADI2	271	Q9Y2J8
IMVSESLAPILPLQY	GREB1L	1756	Q9C091
IILLNTDMYSPNIKP	IQSEC3	786	Q9UPP2
LTLLPATYNSMINPI	GPR3	281	P46089
PTLTLEPVNIMELYL	IL36RN	76	Q9UBH0
LNTDPTMFPYLRSLQ	PLD4	381	Q96BZ4
TMFPYLRSLQALSNP	PLD4	386	Q96BZ4
QMLVPLLLQYLETLS	ARHGAP33	136	O14559
MVSYLNDLPSQRIQP	ACOX1	451	Q15067
LLLSNILYPGMLLTP	CHD9	2796	Q3L8U1
YQSDETLPINPLSML	DOCK2	1516	Q92608
TDSFYPAMRLILPQL	LIG4	61	P49917
NSIMTLLSSLLTYPQ	BTAF1	491	O14981
LVSLLSQLMVSNPPY	DNAJB14	261	Q8TBM8
QLLSRAYTIDPSNPM	CTR9	256	Q6PD62
MNLLSLYTSPSLPNI	HDAC9	316	Q9UKV0
DIDSPLSQLYVMSLL	FSHR	521	P23945
VKSPALLLSQLLPYM	DHRS2	146	Q13268
YLDPTLNPMLNKSVA	DNAH2	3446	Q9P225
TVIPMLNPLIYSLRN	OR8A1	296	Q8NGG7
VVTPMLNPILYSLRN	OR13C3	316	Q8NGS6
LPSSLMYLSLENNSI	OMD	231	Q99983
ITPMLNPLIYTLRNS	OR4A4P	276	Q8NGN8
ITPMLNPIIYTLRNA	OR4B1	276	Q8NGF8
LTPMLNPLIYTLRNE	OR4C3	276	Q8NH37
VTPMLNPLIYTLRNT	OR4C5	291	Q8NGB2
VSDSIITPMLNPLIY	OR4C6	271	Q8NH72
ITPMLNPLIYTLRNA	OR4C6	276	Q8NH72
LLSPDPQMDFLALSQ	NUTM2A	591	Q8IVF1
LLSPDPQMDFLALSQ	NUTM2B	591	A6NNL0
LLSPDPQMDFLALSQ	NUTM2E	591	B1AL46
LAPISIMYQISPSLN	MT-ND2	136	P03891
IMYQISPSLNVSLLL	MT-ND2	141	P03891
DQLPMVLSPLYLLQF	GLMN	301	Q92990
FLLSLDMPISLEYPN	RTTN	506	Q86VV8
IPYLTALLPSELEMQ	TAF8	221	Q7Z7C8
YSISQKLNVPMAPLS	SORT1	466	Q99523
PLSRMAYQASNLPSL	SLC35G3	56	Q8N808
YRNILSSQSMQPPII	RAPGEF6	996	Q8TEU7
ANTMSNYTLLPPSLL	SULT2B1	251	O00204
RSILPDLLSPYQMAI	LRRC27	316	Q9C0I9
TPPATNVLLMLYSNL	NODAL	186	Q96S42
NSINLSIAMDLYSPP	RMI1	476	Q9H9A7
LSPMLNPLIYSLRNT	OR5M1	281	Q8NGP8
IVSIDPDSPLLMTLY	PKD1L3	546	Q7Z443
TLLLMLDYQPPQFKL	SMARCD3	251	Q6STE5
QGLLPSLPQYMIALL	STRIP1	511	Q5VSL9
LSQYQEMQLQPLPST	SIK2	791	Q9H0K1
LSQSVQSIPLYLMPR	TANC2	251	Q9HCD6
SVFYTLLIPMLNPLI	OR8K1	281	Q8NGG5
LLIPMLNPLIYSLRN	OR8K1	286	Q8NGG5
VLSPAETKTLYPLMN	SARDH	181	Q9UL12
PIDNYPIQTLVNMSL	SPATA1	11	Q5VX52
QNIPPLTTYMLVLGL	SGPP2	311	Q8IWX5
VPMFLSTLLAPYQAL	SOAT2	171	O75908
PLSRMAYQASNLPSL	SLC35G4	56	P0C7Q5
PQLPEDLFKSLMYSL	XPO4	996	Q9C0E2
LLAPLATTFPLLMTY	SLC16A4	381	O15374
SYNNIMTVPALPKSL	TLR9	131	Q9NR96
DLLQPPLGYQMNTSS	SCML2	126	Q9UQR0
MESSLLPYVSNILSP	ZBTB18	351	Q99592
EVMQLTYLPTSPLLA	NRDC	1111	O43847
LYLMNSIPLPQKSSA	VPS13C	826	Q709C8
KMPYIQNLSSLPTRT	UNC5D	526	Q6UXZ4
LLIPLRTSMPFYNSE	ZMYND12	56	Q9H0C1
QLYMQPGLPESLLSV	USP24	1706	Q9UPU5
LDPNAMYSLLLDFVP	TBX19	81	O60806
NPDLASSLQYEMLLL	UBR4	3961	Q5T4S7
LSLDLSLNPMNFIQP	TLR4	206	O00206
PSLDPLAMLYKISNS	TSHZ1	766	Q6ZSZ6
EYMVLASPSVPLLQL	TRIM58	391	Q8NG06
FLDMPQSPLFTLNLN	UGGT1	1061	Q9NYU2
ALQDLMLLSQYSPSR	NDC1	331	Q9BTX1