Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintramolecular oxidoreductase activity, transposing S-S bonds

TMX1 PDIA6 TXNDC5

1.49e-0522443GO:0016864
GeneOntologyMolecularFunctionprotein disulfide isomerase activity

TMX1 PDIA6 TXNDC5

1.49e-0522443GO:0003756
GeneOntologyMolecularFunctionprotein-disulfide reductase activity

TMX1 PDIA6 TXNDC5

6.77e-0536443GO:0015035
GeneOntologyMolecularFunctiondisulfide oxidoreductase activity

TMX1 PDIA6 TXNDC5

1.16e-0443443GO:0015036
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS18 ADAMTS6 ADAMTS9 ADAMTSL2

1.40e-04120444GO:0004222
GeneOntologyMolecularFunctionintramolecular oxidoreductase activity

TMX1 PDIA6 TXNDC5

2.69e-0457443GO:0016860
GeneOntologyMolecularFunctionoxidoreductase activity, acting on a sulfur group of donors

TMX1 PDIA6 TXNDC5

2.69e-0457443GO:0016667
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS18 ADAMTS6 ADAMTS9 ADAMTSL2

9.69e-04200444GO:0008237
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS18 ADAMTS6 ADAMTS9 LPA ADAMTSL2

2.46e-03430445GO:0004175
GeneOntologyMolecularFunctionhistone binding

CHD1 KDM1B FMR1 L3MBTL4

2.71e-03265444GO:0042393
GeneOntologyCellularComponentextracellular matrix

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 MUC4 OTOGL LPA ADAMTSL2

6.96e-05656458GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 MUC4 OTOGL LPA ADAMTSL2

7.11e-05658458GO:0030312
DomainTSP_1

ADAMTS18 ADAMTSL1 C7 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

1.40e-1263438PF00090
DomainTSP1

ADAMTS18 ADAMTSL1 C7 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

1.81e-1265438SM00209
DomainTSP1_rpt

ADAMTS18 ADAMTSL1 C7 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

1.81e-1265438IPR000884
DomainTSP1

ADAMTS18 ADAMTSL1 C7 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

1.81e-1265438PS50092
DomainPeptidase_M12B_ADAM-TS

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 ADAMTSL2

2.09e-0924435IPR013273
DomainPLAC

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTSL2

2.40e-0814434PF08686
DomainPLAC

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTSL2

9.20e-0819434IPR010909
DomainPLAC

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTSL2

9.20e-0819434PS50900
DomainADAM_spacer1

ADAMTS18 ADAMTS6 ADAMTS9 ADAMTSL2

2.09e-0723434IPR010294
DomainADAM_spacer1

ADAMTS18 ADAMTS6 ADAMTS9 ADAMTSL2

2.09e-0723434PF05986
DomainThioredoxin_CS

TMX1 PDIA6 TXNDC5

7.56e-0617433IPR017937
DomainTHIOREDOXIN_1

TMX1 PDIA6 TXNDC5

2.52e-0525433PS00194
DomainThioredoxin

TMX1 PDIA6 TXNDC5

4.88e-0531433PF00085
DomainPeptidase_M12B_N

ADAMTS18 ADAMTS6 ADAMTS9

9.80e-0539433IPR002870
DomainPep_M12B_propep

ADAMTS18 ADAMTS6 ADAMTS9

9.80e-0539433PF01562
DomainDISINTEGRIN_1

ADAMTS18 ADAMTS6 ADAMTS9

1.06e-0440433PS00427
DomainADAM_MEPRO

ADAMTS18 ADAMTS6 ADAMTS9

1.06e-0440433PS50215
DomainDISINTEGRIN_2

ADAMTS18 ADAMTS6 ADAMTS9

1.06e-0440433PS50214
DomainReprolysin

ADAMTS18 ADAMTS6 ADAMTS9

1.06e-0440433PF01421
DomainPeptidase_M12B

ADAMTS18 ADAMTS6 ADAMTS9

1.06e-0440433IPR001590
DomainThioredoxin_domain

TMX1 PDIA6 TXNDC5

1.14e-0441433IPR013766
DomainDisintegrin_dom

ADAMTS18 ADAMTS6 ADAMTS9

1.14e-0441433IPR001762
DomainTHIOREDOXIN_2

TMX1 PDIA6 TXNDC5

1.32e-0443433PS51352
DomainDisulphide_isomerase

PDIA6 TXNDC5

1.44e-048432IPR005788
DomainThioredoxin

PDIA6 TXNDC5

3.97e-0413432IPR005746
DomainMetalloPept_cat_dom

ADAMTS18 ADAMTS6 ADAMTS9

8.56e-0481433IPR024079
Domain-

ADAMTS18 ADAMTS6 ADAMTS9

8.56e-04814333.40.390.10
DomainZINC_PROTEASE

ADAMTS18 ADAMTS6 ADAMTS9

1.48e-0398433PS00142
Domain-

TMX1 PDIA6 TXNDC5

2.77e-031224333.40.30.10
DomainThioredoxin-like_fold

TMX1 PDIA6 TXNDC5

3.46e-03132433IPR012336
DomainLDLR_class-A_CS

LRP12 C7

3.82e-0340432IPR023415
DomainCYSTEINE_SWITCH

ADAMTS18 ADAMTS9

4.01e-0341432PS00546
DomainPept_M10_metallopeptidase

ADAMTS18 ADAMTS9

4.40e-0343432IPR001818
DomainLdl_recept_a

LRP12 C7

4.81e-0345432PF00057
Domain-

LRP12 C7

5.03e-03464324.10.400.10
DomainER_TARGET

PDIA6 TXNDC5

5.24e-0347432PS00014
DomainLDLRA_1

LRP12 C7

5.46e-0348432PS01209
DomainLDrepeatLR_classA_rpt

LRP12 C7

5.69e-0349432IPR002172
DomainLDLa

LRP12 C7

5.69e-0349432SM00192
DomainLDLRA_2

LRP12 C7

5.69e-0349432PS50068
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 MUC4 NOTCH2 ADAMTSL2

6.93e-1468369M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

5.53e-1239367M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

5.53e-1239367MM15165
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 MUC4 NOTCH2 ADAMTSL2

6.58e-11143369M27275
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 MUC4 ADAMTSL2

2.49e-10109368MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 MUC4 ADAMTSL2

2.88e-10111368M27416
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 MUC4 NOTCH2 ADAMTSL2

9.32e-09250369M27554
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

ADAMTS18 LYPD6B PDIA6 ADAMTSL1 THSD7B KDM1B THSD7A ADAMTS6 ADAMTS9 MUC4 ZRANB1 ADAMTSL2

1.05e-0413893612MM15307
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

ADAMTS18 LYPD6B PDIA6 ADAMTSL1 THSD7B KDM1B THSD7A ADAMTS6 ADAMTS9 MUC4 ZRANB1 ADAMTSL2

1.88e-0414753612M19806
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS18 ADAMTSL1 THSD7B THSD7A ADAMTS6 ADAMTS9 ADAMTSL2

6.92e-127545720637190
Pubmed

The human protein disulfide isomerase gene family.

TMX1 PDIA6 TXNDC5

1.12e-061645323245351
Pubmed

Functional Variant in the SLC22A3-LPAL2-LPA Gene Cluster Contributes to the Severity of Coronary Artery Disease.

LPAL2 LPA

4.91e-06345227417586
Pubmed

Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.

LPAL2 LPA

4.91e-06345223036009
Pubmed

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

LPAL2 LPA

4.91e-06345219198611
Pubmed

ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.

ADAMTSL1 ADAMTSL2

4.91e-06345214667842
Pubmed

Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice.

FMR1 CHRM1

4.91e-06345227316341
Pubmed

5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family.

LPAL2 LPA

4.91e-0634527679504
Pubmed

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins.

PDIA6 TXNDC5

4.91e-06345219887585
Pubmed

Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor.

KLF12 KLF5

9.81e-0644529858544
Pubmed

Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.

LPAL2 LPA

9.81e-06445221900290
Pubmed

Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

ADAMTS18 ADAMTS9

9.81e-06445216507336
Pubmed

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

KLF12 KLF5

1.63e-05545220101243
Pubmed

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum.

PDIA6 TXNDC5

1.63e-05545221057456
Pubmed

Genetic and clinical correlates of early-outgrowth colony-forming units.

LPAL2 LPA

1.63e-05545221493818
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

TMX1 CYB5B GXYLT1 SIAE LRP12 PDIA6 TXNDC5 NDUFB9 NOTCH2

1.96e-05120145935696571
Pubmed

Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs.

ADAMTS9 NOTCH2

2.45e-05645219247373
Pubmed

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.

ADAMTS9 NOTCH2

2.45e-05645218567820
Pubmed

Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

KLF12 KLF5

2.45e-05645223134681
Pubmed

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.

TMX1 PDIA6 TXNDC5 STXBP3

5.82e-0516245432913203
Pubmed

Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.

ADAMTS9 NOTCH2

5.86e-05945218714373
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS6 ADAMTS9

7.32e-051045211167130
Pubmed

SUMOylation of ERp44 enhances Ero1α ER retention contributing to the pathogenesis of obesity and insulin resistance.

PDIA6 TXNDC5

8.94e-051145236427672
Pubmed

Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits.

ADAMTS9 NOTCH2

8.94e-051145219670153
Pubmed

Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.

KLF12 KLF5

1.07e-041245215937668
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS18 ADAMTS9

1.07e-041245225770910
Pubmed

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.

ADAMTS9 NOTCH2

1.47e-041445219833888
Pubmed

ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.

ADAMTS18 ADAMTS9

1.94e-041645230579834
Pubmed

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

ADAMTS9 NOTCH2

2.20e-041745219502414
Pubmed

Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

ADAMTS9 NOTCH2

2.20e-041745219741467
Pubmed

Genome-wide association analysis of age-at-onset in Alzheimer's disease.

HRK ADAMTS9

2.20e-041745222005931
Pubmed

Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.

ADAMTSL1 STXBP3

2.20e-041745221897333
Pubmed

Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

ADAMTS9 NOTCH2

2.47e-041845219324937
Pubmed

Genome-wide association study of chronic periodontitis in a general German population.

LRP12 CHD1 SCN2A

2.66e-049645324024966
Pubmed

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

ADAMTS9 NOTCH2

2.76e-041945219020324
Pubmed

Genome-wide association study of liver enzymes in korean children.

THSD7B ADAMTS9

2.76e-041945224124411
Pubmed

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.

ADAMTS9 NOTCH2

2.76e-041945219139842
Pubmed

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

ADAMTS9 NOTCH2

3.06e-042045220075150
Pubmed

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

ADAMTS9 NOTCH2

3.06e-042045219862325
Pubmed

Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.

ADAMTS9 NOTCH2

3.06e-042045219933996
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

TMX1 ADAMTSL1 SLITRK1 CLEC12B TRPM2

3.13e-0446045520562862
Pubmed

Genotype score in addition to common risk factors for prediction of type 2 diabetes.

ADAMTS9 NOTCH2

3.38e-042145219020323
Pubmed

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

ADAMTS9 NOTCH2

3.38e-042145218591388
Pubmed

Underlying genetic models of inheritance in established type 2 diabetes associations.

ADAMTS9 NOTCH2

3.38e-042145219602701
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

TMX1 CYB5B PDIA6 TXNDC5 RAB3GAP2

3.39e-0446845531056421
Pubmed

E3 ubiquitin ligase FBXW7 balances airway cell fates.

KLF5 NOTCH2

3.72e-042245234998785
Pubmed

Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.

ADAMTS9 NOTCH2

3.72e-042245219794065
Pubmed

Mapping wild-type and R345W fibulin-3 intracellular interactomes.

PDIA6 TXNDC5

3.72e-042245227777122
Pubmed

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

ADAMTS9 NOTCH2

3.72e-042245218372903
Pubmed

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.

ADAMTS9 NOTCH2

4.07e-042345219720844
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

THSD7A ZNF606 ADAMTS9 SLITRK1 ADAMTSL2

4.29e-0449345515368895
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

TMX1 CHD1 PDIA6 FMR1 TXNDC5 STXBP3 RAB3GAP2 MGAM2

4.34e-04142545830948266
Pubmed

Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.

ADAMTS9 NOTCH2

4.82e-042545220879858
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

KLF12 KLF5

4.82e-042545215820306
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TMX1 C5orf34 CHD1 PDIA6 TXNDC5 STXBP3 NOTCH2 RAB3GAP2

5.76e-04148745833957083
Pubmed

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.

CHD1 TXNDC5

6.06e-042845228655764
Pubmed

Obesity and diabetes genetic variants associated with gestational weight gain.

ADAMTS9 NOTCH2

6.50e-042945220816152
Pubmed

Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis.

CYB5B PDIA6

7.43e-043145223142642
Pubmed

Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.

ADAMTS9 NOTCH2

8.43e-043345220203524
Pubmed

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.

KLF12 NOTCH2

1.00e-033645225715395
Pubmed

Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.

ADAMTS18 ADAMTS9

1.12e-033845218267097
Cytoband6p22.3

KDM1B MBOAT1

9.46e-04464526p22.3
CytobandEnsembl 112 genes in cytogenetic band chr13q22

KLF12 KLF5

1.71e-0362452chr13q22
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS18 ADAMTS6 ADAMTS9

3.92e-061930350
GeneFamilyProtein disulfide isomerases

TMX1 PDIA6 TXNDC5

5.37e-0621303692
GeneFamilyADAMTS like

ADAMTSL1 ADAMTSL2

5.56e-057302947
GeneFamilyZinc fingers C2H2-type|Kruppel like factors

KLF12 KLF5

4.01e-0418302624
CoexpressionNABA_ECM_REGULATORS

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 LPA ADAMTSL2

3.19e-06238456M3468
CoexpressionNABA_ECM_REGULATORS

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 LPA ADAMTSL2

3.51e-06242456MM17062
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 MUC4 LPA ADAMTSL2 CLEC12B

3.26e-05738458MM17058
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 MUC4 LPA ADAMTSL2 CLEC12B

3.69e-05751458M5885
CoexpressionNABA_MATRISOME

ADAMTS18 ADAMTSL1 ADAMTS6 ADAMTS9 MUC4 OTOGL LPA ADAMTSL2 CLEC12B

4.52e-051008459MM17056
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_GRIA2_POS_ARTERIAL_ENDO_CELL

ADAMTSL1 C7 THSD7A ADAMTS6

4.56e-05115454M45752
CoexpressionFULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN

LRP12 PDIA6 FMR1 STXBP3 KLF5 NOTCH2

1.26e-04458456M4785
CoexpressionLAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR

KLF12 THSD7A ADAMTS6 ADAMTS9

1.35e-04152454M39243
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS18 THSD7B THSD7A ADAMTS6 L3MBTL4

7.62e-07169455d161dd8eb22633392b6c6466ee9eff4042464149
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 THSD7B THSD7A ADAMTS6 L3MBTL4

8.80e-07174455fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

9.85e-071784553c973aac16988e88f5677d3d695dd772ccfd6570
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.01e-0617945597ba67a856680f24846244c0b92c886cc0e79537
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.10e-06182455420a8fd30543e37a66ba0786215d056d308660d0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B THSD7A ADAMTS6 ADAMTS9 L3MBTL4

1.13e-061834556e6128c5be5e0a2db6d84eecbf4dddd02d0216f8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.13e-06183455e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B THSD7A ADAMTS6 ADAMTS9 L3MBTL4

1.13e-061834555e361be3ae3fe05098968e58427630127bd12675
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.16e-0618445532473dbdb2de66391157c5814ef34e790806e4f2
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.19e-0618545516e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.19e-06185455027020754dbf71b0034791f9a34ae795e3b85f81
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.19e-06185455cefd81adb480c027545a5c78dcd05669783717f4
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.19e-06185455bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.26e-06187455ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.29e-061884556ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.29e-06188455c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.39e-06191455764c3a8829ae1253a0790744138266e81fc075ec
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.39e-0619145506760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6 L3MBTL4

1.43e-061924553abee376c37c3646da33ac381aa63d50a01607a6
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS18 ADAMTSL1 C7 THSD7A ADAMTS9

1.58e-061964555609b2d93172a488b35d854298a3a4e504e17e28
ToppCellParenchyma_COVID-19-Endothelial-TX-Endothelial-1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ADAMTS18 C7 THSD7A ADAMTS6 ADAMTS9

1.75e-06200455b65fb8d378abd91cdabf5faac5f4b90d527f8c44
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAMTS18 C7 THSD7A ADAMTS6 ADAMTS9

1.75e-062004552cb6e35add34b9dc564ebcf5d3cbc761325ca9f4
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADAMTS18 C7 THSD7A ADAMTS6 ADAMTS9

1.75e-0620045527507c4b41d45c7cc50e4993169c0302be22ee34
ToppCelldroplet-Liver-Npc-21m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS6 CHRM1 FLACC1 ADAMTSL2

1.76e-05154454d883b3e2a65e4375bea1216eb9bbc86c64ee449c
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 MBOAT1 OTOGL SCN2A

1.90e-05157454ed9c9feefc06c9536c03bedbc3397a2ee492a78e
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 MBOAT1 OTOGL SCN2A

1.90e-05157454fddcb24776b9f86e000208bae54541b15b2adefd
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LYPD6B ADAMTSL1 MUC4 KLF5

2.10e-051614542d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

C7 THSD7B MBOAT1 SLITRK1

2.26e-051644544d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 THSD7B MBOAT1 SCN2A

2.42e-05167454edc5f04584b44f99ff9a62bbe0dab6fc044fb334
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NPFFR2 LRIT2 OTOGL

2.50e-0556453af55596513ddbe60b08648b27e41a7b65e3da58c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7A ADAMTS6 L3MBTL4

2.60e-0517045431e3f57673c99f4d8ef30faa9c40e5f7f5bf6460
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS18 NPFFR2 OTOGL NOTCH2

2.60e-051704545570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7A ADAMTS6 L3MBTL4

2.60e-0517045436dbbdb13f69307afd2122ff051b2980850c1f00
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6

2.66e-05171454a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LYPD6B MBOAT1 KLF5 TRPM2

2.78e-05173454b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LYPD6B MBOAT1 KLF5 TRPM2

2.78e-05173454120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6

2.91e-05175454e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KLF12 THSD7A ADAMTS6 L3MBTL4

2.91e-051754549d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCellCOVID-19-kidney-CD-IC-A|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTS18 ADAMTSL1 THSD7A SCN2A

2.97e-0517645445028197364c64e93e3ffe86aff773d47a477d49
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7A ADAMTS6 L3MBTL4

3.04e-05177454fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A ADAMTS6 NOTCH2 L3MBTL4

3.04e-0517745484116796ca4c7007508c0f1a68a1135c7b922278
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 MBOAT1 ADAMTS9 CHRM1

3.11e-05178454cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A ADAMTS6 NOTCH2 L3MBTL4

3.11e-051784542a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6

3.18e-05179454cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

LYPD6B THSD7A ADAMTS6 ADAMTS9

3.18e-051794541ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS18 ADAMTSL1 THSD7B THSD7A

3.18e-05179454e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6

3.18e-0517945401302505816f272243659e20d751b61a198a2fc0
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A L3MBTL4

3.18e-05179454c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DNAH3 THSD7B THSD7A L3MBTL4

3.25e-05180454b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6

3.25e-05180454c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B THSD7A ADAMTS6 L3MBTL4

3.39e-051824547dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A ADAMTS6 NOTCH2 L3MBTL4

3.39e-05182454d3a037268f026eb2f84428b1821022503cef7756
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

MUC4 KLF5 SCN2A MGAM2

3.46e-0518345415d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellPosterior_cortex-Neuronal-Excitatory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HRK CHRM1 SLITRK1 SCN2A

3.54e-0518445425ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A L3MBTL4

3.61e-05185454487fa382232564f075960899d50afa0edae5d258
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B THSD7A ADAMTS6 L3MBTL4

3.61e-0518545408fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B THSD7A MBOAT1 SCN2A

3.61e-05185454d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B ADAMTS6 L3MBTL4

3.69e-05186454fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B THSD7A ADAMTS6 L3MBTL4

3.77e-0518745402105c82a9ba79d2f19e002188377fc3440770c2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B THSD7A MBOAT1 SCN2A

3.77e-05187454e3095455d2f255854f339f6b05fa87852af0700f
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 THSD7A ADAMTS6 ADAMTS9

3.85e-05188454d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B THSD7A MBOAT1 SCN2A

3.93e-051894543a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B THSD7A MBOAT1 SCN2A

3.93e-05189454fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCellEndothelial-A-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ADAMTSL1 C7 THSD7A ADAMTS9

3.93e-0518945404b565855f58ca0f343904d04be657b66e109076
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 C7 ADAMTS6 KLF5

4.01e-05190454efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 THSD7A MBOAT1 SCN2A

4.01e-05190454b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7A ADAMTS6 L3MBTL4

4.18e-051924546a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 THSD7A ADAMTS6 ADAMTS9

4.18e-0519245427ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7A ADAMTS6 L3MBTL4

4.18e-05192454025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6B THSD7B THSD7A ADAMTS6

4.18e-05192454bf1943715085c4124b1675888b0615c9500ec888
ToppCellRA|World / Chamber and Cluster_Paper

C7 OTOGL ADAMTSL2 L3MBTL4

4.35e-0519445408f0afbb68a63150fbe107a5337299081c3f69e4
ToppCellsevere-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TXNDC5 HRK ADAMTS6 SCN2A

4.35e-051944542fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B ADAMTS9 KLF5 SCN2A

4.35e-0519445446070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6B ADAMTS9 KLF5 SCN2A

4.35e-05194454abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MBOAT1 NOTCH2 MGAM2 L3MBTL4

4.44e-05195454e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCellfacs-Heart-LA-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C7 TXNDC5 NOTCH2 ADAMTSL2

4.44e-0519545479a6e8e6de040ff07539e8901fc407363a50e355
ToppCellfacs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C7 TXNDC5 NOTCH2 ADAMTSL2

4.53e-05196454ad1838dabd043cb140260843e3527d8c7d58850e
ToppCellfacs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C7 TXNDC5 NOTCH2 ADAMTSL2

4.53e-05196454cbc15c0769016fe9972445169029bd8d14a7e6ef
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NPFFR2 THSD7A ADAMTS6 ADAMTS9

4.62e-05197454ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCelldistal-Endothelial-Bronchial_Vessel_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADAMTS18 C7 THSD7A ADAMTS9

4.62e-051974540d1afd1ad7489c071db08b3dfff598423097d7e0
ToppCellfacs-Heart-LA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C7 TXNDC5 NOTCH2 ADAMTSL2

4.62e-051974542a91738cb6d7588869dd00deeea0cbbc2d6aa34d
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ADAMTS18 C7 THSD7A ADAMTS9

4.62e-05197454f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCelldistal-Endothelial-Bronchial_Vessel_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ADAMTS18 C7 THSD7A ADAMTS9

4.62e-05197454f45a93b5ad80a16b760acbaa6467648ffc05a0d3
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAMTS18 C7 THSD7A ADAMTS9

4.62e-0519745496d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADAMTS18 C7 THSD7A ADAMTS9

4.62e-051974541a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

ADAMTS18 CHD1 ADAMTSL1 ADAMTS9

4.71e-05198454b8bd1ba268480f54451648e01631b615a3401144
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 C7 NOTCH2 ADAMTSL2

4.71e-05198454a860246bcea847249a78fd2e86ed8e04371060db
ToppCellNon-neuronal-Non-dividing-Radial_Glia-early|World / Primary Cells by Cluster

PDIA6 STXBP3 HRK ADAMTS6

4.80e-05199454549391e7a4285da1c0e366654530bcf1cd33fbae
ToppCellNon-neuronal-Non-dividing-Radial_Glia-early-40|World / Primary Cells by Cluster

PDIA6 STXBP3 HRK ADAMTS6

4.80e-0519945423625d757173bdd35a51c7919ff4b588168d2553
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MBOAT1 MUC4 KLF5 L3MBTL4

4.80e-05199454527aae1d9d37a50deefc01fc0c064a53673681bd
ToppCell15-Trachea-Epithelial-Club-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

LYPD6B MUC4 KLF5 NOTCH2

4.80e-0519945401bc88d9da528e5842b415a32b519b7f53e4cbab
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTS18 C7 THSD7A ADAMTS9

4.80e-051994546fb81388c5045e81c3849a7136bdff3f953f044e
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-ADAMTSL1|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7B THSD7A ADAMTS6 L3MBTL4

4.89e-05200454e1fca7ee2dc18c7fded53c3561f519c1fcd9767a
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

KLF12 THSD7A KLF5 NOTCH2

4.89e-05200454f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-HS3ST3A1|Neuronal / cells hierarchy compared to all cells using T-Statistic

LYPD6B THSD7B THSD7A ADAMTS6

4.89e-05200454dd68ce6934eafb75d918042fcf7fd7a750294b7f
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

KLF12 THSD7A KLF5 NOTCH2

4.89e-052004541639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_1|Neuronal / cells hierarchy compared to all cells using T-Statistic

LYPD6B ADAMTS6 NOTCH2 L3MBTL4

4.89e-052004549f21e4e0913d8ef95a3f771dff0abaad8fe1d9f2
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

LYPD6B THSD7B THSD7A ADAMTS6

4.89e-052004549ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

LYPD6B THSD7A ADAMTS6 L3MBTL4

4.89e-05200454de23a5d22d94935802b5b84a9e029b3f62c57028
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7B THSD7A ADAMTS6 L3MBTL4

4.89e-05200454c1797542541747b524c9c22c723d24c8d027d486
Diseasechronic kidney disease, APOL1 risk genotype carrier status

OTOGL LPA

2.27e-055452EFO_0003884, EFO_0009324
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

LPAL2 LPA

4.75e-057452EFO_0004614, EFO_0006925
DiseaseFacies

FMR1 ADAMTSL2

1.02e-0410452C0282631
DiseaseManic Disorder

THSD7A SCN2A TRPM2

1.76e-0471453C0024713
DiseaseManic

THSD7A SCN2A TRPM2

2.33e-0478453C0338831
Diseasetriglycerides to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

2.36e-0415452EFO_0022328
DiseaseDepression, Bipolar

THSD7A SCN2A TRPM2

2.42e-0479453C0005587
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

3.05e-0417452EFO_0022232
Diseaseenergy expenditure measurement

KLF12 THSD7B

4.25e-0420452EFO_0008005
Diseasefree cholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

4.69e-0421452EFO_0022277
Diseasecholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

4.69e-0421452EFO_0022246
Diseasedocosahexaenoic acid to total fatty acids percentage

LPAL2 LPA

4.69e-0421452EFO_0022262
DiseaseR-warfarin measurement

ADAMTSL1 RAB3GAP2 SCN2A L3MBTL4

7.09e-04265454EFO_0803324
Diseasebrain cancer (implicated_via_orthology)

NOTCH2 L3MBTL4

7.22e-0426452DOID:1319 (implicated_via_orthology)
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

ADAMTSL1 THSD7A

7.22e-0426452EFO_0005325, EFO_0005532, EFO_0010735
Diseaselongevity, healthspan, parental longevity

FLACC1 LPA

8.99e-0429452EFO_0004300, EFO_0007796, EFO_0009762
Diseaseanxiety disorder

THSD7A MGAM2

9.63e-0430452EFO_0006788
Diseasepresubiculum volume

ADAMTSL1 HRK

1.03e-0331452EFO_0009400
Diseaseintraocular pressure measurement

ADAMTS18 LRP12 THSD7A ADAMTS6 KLF5

1.04e-03509455EFO_0004695
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

LPAL2 LPA

1.24e-0334452EFO_0008317, EFO_0008596, EFO_0020944
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

LPAL2 LPA

1.24e-0334452EFO_0008317, EFO_0008596, EFO_0020947

Protein segments in the cluster

PeptideGeneStartEntry
SSLSPWKCPWFVYCF

nan

6

A4D1N5
CKWQGLPYSECSWED

CHD1

411

O14646
CNAFSCPAYWMPGEW

ADAMTS18

926

Q8TE60
PQWVALDWSECTPKC

ADAMTS6

961

Q9UKP5
KTSPVYWCREDWPNQ

NPFFR2

301

Q9Y5X5
CCWEYVVQWNKDPEE

RAB3GAP2

1016

Q9H2M9
EPQSWCCRWNDKPYL

MUC4

4646

Q99102
NPWANCSSPLPCWDY

NOTCH2

1461

Q04721
WPSEYPAKINCSWFI

LRP12

66

Q9Y561
MYPNPLIYCTCWDPW

FLACC1

1

Q96Q35
RWQYKCCWSPVADAN

MGAM2

66

Q2M2H8
AYAWAAQGPCSCSKW

LRIT2

481

A6NDA9
PCNIFDCPKWLAQEW

ADAMTSL1

431

Q8N6G6
DCPKWLAQEWSPCTV

ADAMTSL1

436

Q8N6G6
CYWNPYWMLPSDVCG

GXYLT1

81

Q4G148
ERPCFKWYTSPWSEC

ADAMTSL2

851

Q86TH1
WCDVNSPYVQPVGWC

L3MBTL4

236

Q8NA19
FPCPQWKSGDWSECL

ADAMTS9

1051

Q9P2N4
EVYSRANEKEPCCWW

FMR1

66

Q06787
LPYWVQCTKPECRKW

KDM1B

136

Q8NB78
CCTIDWFQSWPTDAL

DNAH3

2586

Q8TD57
VNCQWDFYAPWSECN

C7

26

P10643
NDTCKSCWAYWILPI

CYB5B

116

O43169
CKDCVPETLWELGYW

CHRM1

391

P11229
PWCYTMDPNVRWEYC

LPA

1226

P08519
PWCYTMDPSVRWEYC

LPA

1446

P08519
WLKCVCYQRVPWYPT

MBOAT1

356

Q6ZNC8
PYKCTWEGCTWKFAR

KLF12

346

Q9Y4X4
CWSVAACPEEWKYPL

C5orf34

241

Q96MH7
KCYVPESCPCIWKDW

OTOGL

901

Q3ZCN5
ESCPCIWKDWEYLSG

OTOGL

906

Q3ZCN5
YAPWCGHCKNLEPEW

PDIA6

186

Q15084
PTYWPWLCAAAQVAA

HRK

66

O00198
PCPSDCKLSEWSNWS

THSD7A

1031

Q9UPZ6
CPGDCYLKDWSSWSL

THSD7A

1411

Q9UPZ6
PWCYTTDPNVRWEYC

LPAL2

86

Q16609
CYKVPEWCLDDWHPS

NDUFB9

96

Q9Y6M9
AWTTWPCEYKQCPLY

SIAE

481

Q9HAT2
DSKEWPYCSQCPAVW

STXBP3

491

O00186
SDHRCNPCPKMWQWY

CLEC12B

136

Q2HXU8
WECSCTIVPFKQWAE

SLITRK1

531

Q96PX8
FQPVPSWCECAIYLW

TRPM2

821

O94759
PPCWYKFANMCLIWD

SCN2A

726

Q99250
YAPWCGHCKTLAPTW

TXNDC5

346

Q8NBS9
SEWGLWSKCPQSCDP

THSD7B

1131

Q9C0I4
DWMIEFYAPWCPACQ

TMX1

46

Q9H3N1
IKWACEYCTYENWPS

ZRANB1

6

Q9UGI0
TAVDPWASWALCPQY

ZNF606

21

Q8WXB4
KPYKCTWEGCDWRFA

KLF5

401

Q13887
RWAEDKWCPQNTQYC

LYPD6B

76

Q8NI32